It's pretty safe to say the entire game is full of TearJerker moments.
* On the Incan Gold Ship,[[spoiler: discovering that the people you've just met have actually been dead for centuries and never got to take the trip they were dreaming of.]]
* In Larai Cliff, finding the skeleton of an adventurer with a note from his children wishing for his safe return.
** And much later in Watermia, you can find his children who have no idea he's dead, and are still expressing hope that he'll return. You just couldn't have the heart to tell them otherwise, either.
* Just before the final boss fight, [[spoiler: you're transported to the roof of Babel Tower, where you meet with the pure souls of people you met throughout your adventure, including Seth, Hamlet, and your opponent from Russian Glass, who laments, "Living with a terminal illness was better than this,"]]
* [[spoiler: Hamlet's HeroicSacrifice at Angkor Wat]]. Bonus points for it happening ''completely out of the blue.''
* Ishtar's fate. [[spoiler: After you go through his SecretTestOfCharacter to retrieve the antidote that will restore Kara to normal, you go back to his room to find him sealed inside his newest, final painting - a self-portrait. He doesn't tell you why he did this, only that you must take care of Kara.]]
* The backstory of your opponent for [[RussianRoulette Russian Glass.]] He's a longtime champion of the game, but [[spoiler: is secretly suffering from a terminal disease. When you face him, he's gotten to the point where he's playing to lose, so that his family will live a comfortable life with the money he accumulated from years of winning.]] The next morning when his now-widow gives you his will, she also leaves you with a single message that puts the icing on this TearJerker cake: [[spoiler: "We don't need money. Real joy is being with those you love."]]