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Yes, even ''[[SadistShow Family Guy]]'' has moments that make you want to cry, despite being buried under ComedicSociopathy.
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* ''Family Guy'' [[GagSeries of all shows]] pulled one off in the episode "Brian Wallows and Peter's Swallows". First, Brian [[spoiler: convinces a shut-in to enjoy the outside world, only to watch as she gets hit by a truck. They then spent her last few moments on Earth imagining what their future would have been like together with a virtual reality helmet.]] Meanwhile, Peter [[spoiler:is forced to release some swallows who have taken up residence in his beard, and to whom he had gotten rather attached.]] Seth [=MacFarlane=] himself said this is one episode that contains "real emotional content".
* In the otherwise hilarious "Road to Germany", the scene where nerdy Jewish ButtMonkey Mort Goldman, transported back in time to Warsaw in September of 1939, dances happily-- the only moment of happiness we've ever seen the character have-- with all of his old relatives at a wedding while "Tradition" from ''Fiddler on the Roof'' plays, interspersed with the Nazi invasion. It was as though the writers were acknowledging that even a BlackComedy like ''Family Guy'' has to address the Holocaust with at least one moment of solemnity before getting back to ThoseWackyNazis.
* ''Quagmire's Baby''. As one could probably tell, Quagmire gets a doorstep baby from one of the many women he slept with ([[FridgeLogic though an earlier episode -- the first one featuring James Woods -- established that Quagmire knows he has illegitimate children somewhere in the world [including a 20-year-old man in Spain who lives with his mom and twin girls who now work as strippers], so why would be surprised about Anna Lee]]?). He gets rid of it, but finds himself attached to his child. The episode ends with Quagmire trying to get his baby back, but after observing her adoptive family's joy, decides it would be best to let her go. [[KavorkaMan He still hasn't changed all that much]] ([[{{Squick}} implying that he might have sex with her when she turns 18]]), but the moment is still surprisingly poignant.
* Brian's efforts to get people to realize animals' lives are as important as those of humans in ''Dog Gone'' ending in utter failure.
** The scene pictured at the top occurs when, to prove that the Griffins love Brian, Stewie takes his collar to a bar and burns the bar down while a stray dog wearing the collar is inside. The firefighters are led to believe that the stray's burnt corpse was Brian thanks to the collar and give the news to the Griffins. Though the viewer knows that Brian is perfectly fine, it's still heart-wrenching to see the family's reactions.
* [[spoiler:There is also the episode when Brian plans to give up his kidneys to save Peter after Peter's kidneys shut down from drinking a homemade energy drink with kerosene in it. And when Stewie finds out, besides the way he cries, he feels pain because he believes Brian would leave him alone in the world. Plus the scene after Brian first agrees to give up his kidneys and Peter just hugs him tearfully, stroking him silently as Dr. Hartman and a tearful Lois look on.]]
* In "Seahorse Party" (part two of the SethMacFarlane hurricane crossover special, featuring ''WesternAnimation/TheClevelandShow'' and ''WesternAnimation/AmericanDad'') Meg's breakdown at her life as a ChewToy. Especially all the [[ReasonYouSuckSpeech Reason You Suck Speeches]] she gives to Chris, Lois and Peter about how much of a bunch of jerks they are. Even further is her acceptance at being a ChewToy to keep the family from falling apart.
* The entire episode "Screams of Silence: The Story of Brenda Q.", but especially Quagmire's speech to his sister at the intervention.
-->"Brenda, the fact that you are being abused has affected my life in the following ways. The sister that I knew and loved growing up no longer exists. The person I see before me right now is just a punching bag. And I call you "person" and not "woman," because a woman is a strong, beautiful vibrant creature. A woman embraces life, a woman makes choices to make her life better. Sadly, the fact that you are with Jeff proves to me that you have made a choice to make your life worse. ''(tearing up)'' I...I want the girl who I grew up with back. I want...I...I want my sister back."
** And this is coming from '''QUAGMIRE'''. The same Quagmire who often slips roofies into his date's drinks, steals women's used shoes to satisfy his foot fetish, has a sex doll of Lois hidden in his bedroom that he uses as a StalkerShrine, and doesn't use protection at all during sex (despite that he has every venereal disease known to man) actually cares about his sister and wants her to get out of being abused by her boyfriend.
* In "Amish Guy", Meg is told by an Amishman to stay away from his son. How does Meg respond? She ''actually cries''. This even angers '''[[PapaWolf Peter!]]'''
** Followed by her [[CrossesTheLineTwice getting pooped on by a horse]].
** Then near the end, when Meg and Eli share a final goodbye.
* The episode where Peter gets a stroke and suffers just trying to live his life while his whole left side of his body is paralyzed. It was Peter's fault that he caused the stroke to himself by eating 30 hamburgers in one sitting, but for anyone who has or had a friend or family member suffering from a stroke, Peter's suffering can hit home.
-->'''Peter:''' I hate being all strokey!
* The "Lieutenant Shiny Sides" cutaway in "Meet the Quagmires" is played for slight laughs, but it's enough to tug at the heartstrings of anybody who had a pet they really loved and were in denial when it died.
* In "Quagmire And Meg", nobody shows up to Megs 18th birthday party. It's sad because Peter and Lois ''actually feel sorry for her'' (even though the later episodes do show Peter and Lois as treating their children like crap -- especially Meg, to the point that she may be mentally ill [a couple of episodes reveal that she cuts herself and hears voices in her head]). Lois even told Chris to pay kids from school to come.
* Peter killing Quagmire's cat on "Episode 420" [[note]]The one where Brian petitions Quahog to legalize marijuana[[/note]]. The cat was one of the few things he loved other than women, and it's shown that he's clearly distraught about his disappearance (he didn't know that his cat was dead until the end when the main story about Brian's marijuana campaign fizzles out).

-->'''Peter:''' ''(beat)'' ''(takes reward from him)'' I killed your cat. ''([[KickTheDog slams door on him]])''
* Some scenes from "Brian and Stewie," particularly [[spoiler: the revelation that Brian keeps a gun and a bottle of Scotch in his bank vault for when the day comes that he becomes so sick of living that he can have one final drink before he kills himself, and Stewie telling Brian that he's the only person he cares about in this world and he'd be lost if he died]].
* Twelve-year-old Camilla Stull, who had fought a three-year battle with leukemia, had her dream of being an actress come true when Creator/DrewBarrymore introduced her to SethMacFarlane and gave her a voice-over role in "Boys Do Cry". She died 13 days before it aired.
* Basically, the treatment of Meg in the later episodes (in the early episodes, Meg was just a generic teenage girl character that wanted to be like the popular kids and hated her family for being embarrassing and not letting her do what the other kids do) is a major tear jerker. It's pretty depressing how [[AllOfTheOtherReindeer the majority of the world hates you]] for just being yourself and treats you like crap. Dealing with physical and emotional abuse daily can really hurt your self-esteem and sanity, which is why Meg shows tendencies of mental illness.
* Peter and Lois accidentally destroying Chris' self-esteem in "Space Cadet".
** Also Chris writes an essay about what his teacher does after school, saying that she eats a roll of cookie dough, throws it up and puts doll clothes on a sonogram picture.
* Brian's BreakTheHaughty moment in "Brian's Play".
* Brian imagining[[WhatCouldHaveBeen what life could have been like as a puppy if he had gotten to stay with his mother and siblings]] while listening to Stewie singing Anne Murray's "You Needed Me" in "Chris Cross".
** Actually, it's rather vague about whether it was a ImagineSpot or an actual flashback Brian was having. One thing was for sure: it went well with the song.
* In ''A Fistful of Meg,'' after Meg was threatened to be murdered by Mental Mike in a fight, she goes to her mother for help. However, Lois coldly scoffs her for wanting to go to another school saying that it would cost too much, not noticing how she was clearly horrified for her life. Also in this episode, her own friends decided to steer clear of her leaving her alone to face her tormentor.
* [[spoiler: Let's not even start talking about "Life of Brian". By now, you've probably seen enough on the internet to know how much of an offender to this trope that episode is.]]
*** HOWEVER...all this it notably retconned ''Christmas Guy'', in which Brian [[spoiler: was saved from ever having been killed]]; since then, his death has been written out of the Family Guy continuity and has become much easier for fans to talk about.
* The episode where [[spoiler: Brian is brought back]] in question has Stewie asking for Santa to bring Brian back for Christmas, as this will be the Griffins' first Christmas without him.
** Vinny's reaction to Stewie weeping for Brian, as he both feels sorry for Stewie and the fact that he'd never truly replace Brian. He even tries later on to emulate what Brian was like just to cheer Stewie up.
** Also, despite their short time together, Stewie saying goodbye to Vinny before leaving to save Brian was pretty sweet.
* From "Meg Stinks!"
** Peter telling Meg that he does love her (despite all the crap and abuse she has to take from him) and doesn't wish that she was never born.
** Peter crying when Meg tells him that she needs to grow up and go to college.
* The flashbacks in "He's Bla-ack!" of Cleveland and Peter's times together, complete with the [[DarkReprise melancholy rendition of Cleveland's theme song]].
* Stewie's tantrum when Peter and Chris break the TV in "Chap Stewie" can be pretty heartbreaking to watch. [[MoodWhiplash Until he bites Lois and headbutts Meg hard enough to break her nose, that is.]]