* The opening where Lucas is a zombie, and sitting alone being depressed. The whole game from that point is one big HowWeGotHere.
* The death of [[spoiler:Tiffany Harper]].
* The death of [[spoiler:Jade]].
* The death of [[spoiler:any of the children in the Wishita flashback]]. Made even worse because, unlike the above two, it ''is'' avoidable.
* The 'bad' ending, in which [[spoiler:most of humanity has frozen to death and the survivors live in sewers praying for a savior]].