* Ronnie Mitchell finally finding out Danielle was her daughter and the climax of it. ''Dear God.'' For the record, Ronnie always thought her daughter was dead thanks to her asshole of a father Archie until his wedding to Peggy revealed the truth. Ronnie chased after Danielle, only for Janine Butcher to accidentally run Danielle over.
* Ronnie again, finding the corpse of her newborn son.
* Frank Butcher's funeral. Made even more poignant as the actor who played him, the lovable Mike Reid, had died. It's not just the characters crying there, it's the entire cast themselves. "Take care of yourself, Pat."
* Billie Jackson's death. No big build up, just a party gone too far and a guy drinking himself to death. However, the episode dealing with the immediate aftermath was crushing; there were only about three lines of dialogue in the last 10 minutes as the characters tried to deal with the shock, and the tone was shockingly downbeat, even for EastEnders.
* Sharon sitting by the open grave of her husband Dennis, completely breaking down with grief.
-->'''Sharon''': He won't like it here. It's so lonely. He doesn't like being on his own. He says he's not bothered, but it's all a front, cos he hates it. It makes him unhappy. He likes being with ''me''... I met him at a funeral. The first place I ever saw him was in a graveyard... And he was all on his own... my ''darling''...
* Bradley Branning's death in the live 25th anniversary episode.
* When Phil discovers that Ben has accidentally killed Heather. Ben's immediate reaction is point out that ''this'' is what Phil always wanted him [[ARealManIsAKiller to be like.]]
* Ethel Skinner was the show's original old aged pentioner and met her end in 2000, passing away on her birthday after asking Dot to help her die via euthanasia.
* Jamie's death after Martin runs him over.
* When Kat tells Alfie she's been having a three month affair with another man, Alfie breaks down into tears, almost hits her when she won't tell him the other man's name and then violently throws her out, while still crying like a school boy.
* When Lola has her baby taken from her by Social Services.
* The day after Derek's death, we learn that he had arrange to meet up with his father, who is still recovering from his stroke. Having got dressed up for a day out with his eldest son, Jim called the Branning house when Derek didn't show up in time. One can only imagine the look of utter sadness on Jim's face when he was informed of Derek's passing.
* Zoe calling Kat "Mum" for the first time when they said their goodbyes just before Zoe caught her train out of the series.
* The entire episode where the Beale family learns of Lucy's death. First there is Ian who can clings to even the shred of hope that it's all just a nightmare until he sees her dead body, then there his the informing of Cindy and Bobby which is done out of view with cries in audible. The most heartrending however is when Peter finds out about her, both he and his father sobbing in each other's arms along with Peter screaming was harrowing beyond words.
* Jay telling Dexter that he shouldn't try and re-form a relationship with his estranged father because he'll only leave again and break your heart becomes this when you realize that Jay was reunited with his father only for him to be violently murdered a year later leaving Jay an orphan.
* Abi, after heavily drinking, and being dumped by Jay, accidently runs over and kills her dog, Tramp, while trying to leave for Univesity when her dad refuses to up-and-take her until she sobers up.
* Wellard being put down is one heck of a tearjerker.
* Ian has a heart-to-heart chat with Phil following Lucy's death and breaks down in his on-and-off nemesis' arms.
* The sudden death of [[CoolOldLady Nana Moon]] at Christmas, though it was known she was going to die, it was still a shocker. Alfie's reaction makes things worse.
* Cindy reading Ian the letter Lucy had written apologising for her behaviour before she was killed in the 30th anniversary episode. The impact was increased by the fact that the episode was completely live.
* Surprisingly Nick Cotton's death ends poignantly. Rather than the climactic end one would expect, he slowly succumbs to poisoning from heroin and dies in his mother's arms, and perhaps for the one sincere time in his life, asks for her forgiveness over all his past sins. Though Dot can't quite answer that request, when he finally passes, she respectfully closes his eyes and gives him a kiss on the forehead.