* Finding out that [[spoiler: Nicole was DeadAllAlong]] in Dead Space. Despite being a HeroicMime, You can help but feel sorry for Isaac at the part.
-->[[spoiler: ''Nicole:'']] I didn't want it to end like this. I really wanted to see you again...just once. I loved you. I've always loved you.
** The animation Isaac goes through during the revelation - even though you never see his face, his body language speaks volumes for just how badly it hits him. Even worse if you read his in-game diary: [[spoiler:he knew Nicole was dead, but kept himself in denial up until that point]]. Ouch.
* The audio log from the poor bastard who ''cut all his own limbs off'' to keep himself from being a danger when he got infected--and only asks that someone tell his wife and kids that he loves them.
*** What makes it even worse? [[spoiler:It didn't work.]]
* Finally finding Acting Chief Engineer Jacob Temple and Dr. Elizabeth Cross, whose audio logs you've been listening to through half the game.
* In the colony, in the room where you find Neumans emergency broadcast, there is a writing on the wall addressed to someones father, to not leave things unsaid.