* Make sure you've read all the [[color:purple: Waluigi in the Family]] strips, then read the [[http://brawlinthefamily.keenspot.com/2009/09/29/191-triloigi/ Waluigi Trilogi]], where things get even crazier. Then, reach the bottom and realize you are a horrible person for judging Waluigi so harshly.
** [[http://i974.photobucket.com/albums/ae223/Kuraulyek/Happy_Birthday_Waluigi.png?t=1254589528 Someone felt the same]], so they made an [[CrowningMomentOfHeartwarming Alternate Ending]].
* [[http://brawlinthefamily.keenspot.com/2009/11/20/200-ode-to-minions/ Comic #200.]]
* [[http://brawlinthefamily.keenspot.com/wp-content/uploads/CaptainLoucxx1.jpg This tribute]] definitely counts for those of us who grew up with [[Series/TheSuperMarioBrosSuperShow Lou Albano as Mario]].
* [[http://brawlinthefamily.keenspot.com/2011/06/11/340-comic-review-e3-2011/ Adeleine doesn't get to be in the new Kirby game]].
* [[http://www.youtube.com/watch?v=tpeXTgwh7F4 If it Takes a Lifetime]].
* [[http://brawlinthefamily.keenspot.com/2011/11/11/378-fantasy/ Poor Luigi...]]
** [[spoiler: That's right, he apparently literally can't even ''fantasize'' himself as a hero.]]
** But it instantly gets [[CrowningMomentOfAwesome bet]][[CrowningMomentOfHeartwarming ter]] [[http://brawlinthefamily.keenspot.com/2012/12/21/457-luigis-holiday-vacation/ on his vacation to Hyrule]]. [[spoiler:He goes on Link's [[VideoGame.TheLegendOfZeldaOcarinaOfTime Ocarina of Time]] quest rather than Link himself, and not only saves the day, but also gets the same recognition Link would.]]
* In real life: Matt, after having to postpone comic 400 for about a week and a half due to health problems, finally told us just how bad it was. The emphasis he puts on the [[TheWoobie pain he's in]] is staggering.
* [[spoiler: Even though it ended with a joke,]] The strip [[http://brawlinthefamily.keenspot.com/images/End.jpg End]]. Kirby's "It's too hot" just brings a tear to the eye for some reason. Of course, YMMV.
** Apparently, Matt made it during a CreatorBreakdown after his Wii lost all of its data. So really, the comic is mirroring what Matt feels happened to him: all of his favorite adventures and characters have been destroyed. It really shows the affect games can have on people and why they're so important to us.
* [[http://brawlinthefamily.keenspot.com/2012/09/11/436-slippy-battletoad/ Slippy's dejected expression on panels three and four.]]
** [[MoodWhiplash Followed by him casually going through]] [[ThatOneLevel Stage 3]].
* While the Mushroom Kingdom Carol has its hilarious moments, it's ''heartbreaking'' to see Mario change from his jovial, happy self to a bitter, cynical miser in the years since losing to Bowser ([[spoiler: really Jr]]). Luckily, he snaps out of it..
* Comic 515. [[http://cdn.brawlinthefamily.keenspot.com/comics/2013-10-01-515-InHeavensHands.jpg Another tribute comic, this time, to the legendary Hiroshi Yamauchi.]]
* Comic 517 is, while funny, a little heartwrenching when, at the end, Sonic has his "Blue Blur" nickname stripped from him and given to Mega Man. PlayedForLaughs though it may be, anyone who's ever dealt with the AlwaysSomeoneBetter trope in real life and had a similar situation will sympathize greatly.
* The [[http://brawlinthefamily.keenspot.com/2014/02/17/in-loving-memory/ announcement]] after comic 545. [[spoiler: RIP, Terra Taranto.]]