* The story and eventual [[BodyHorror fate]] of Hank Reiss in the ''Zombie Island'' DLC. His ECHO logs detail his love for his wife and children, one of whom made a [[NiceHat macaroni hat]] for him that he wears every day. He ends up transforming into a were-skag and killed in self-defence.
* [[spoiler:TK Baha's]] death.
** Thankfully, the ''Zombie Island'' DLC brings him back. As a zombie. But at least he is funny and allied.
* Every time you defeat a Rakk Hive. Shortly after collapsing, their innards appear to, quite literally, explode from the inside, exposing their ribcage and pulsating organs for all to see.. and the poor creatures are visibly ''still breathing''.