The Tear Jerker page for ''Film/BladeRunner2049'' can be found [[TearJerker/BladeRunner2049 here]].
[[caption-width-right:350:"All those moments will be lost... in time... like tears in rain. Time... to die."]]

* The cruel way Deckard completely undresses Rachael's humanity, recalling memories no one else could have known had she been a real human. The way she throws away her treasured photo of herself and her mother is heartbreaking.
** Rachael already suspected the truth, especially after Tyrell wouldn't see her after the Voight-Kampff test. She went to Deckard for reassurance, and got smacked in the face with a harsh truth.
* Zhora's retirement. It emotionally sets up Roy's reprieve of Deckard. The song played during this scene, "Blade Runner Blues", also helps give the scene its mood.
** In particular, the fact that she's established as having been designed for combat and killing. When she actually fights Deckard, she gets him two solid hits and then spends the rest of the scene running or hiding as Deckard doggedly pursues her, leading to her drawn-out death as she continues to try to flee despite her wounds.
** The narration in the theatrical cut has Deckard stating the fact she was an android didn't make him feeling any better for shooting a woman in the back. Even without the narration, Deckard looking disgusted with himself. Then there's a shocked and dismayed Leon looking from afar.
* The way Roy [[spoiler:reacts to brutally killing Tyrell]] is very human and has overtones of sadness and reluctance. Couple this with Sebastian's reaction [[spoiler:at seeing his supposed ally kill his boss and close friend]], Roy's subsequent apology ([[spoiler:"I'm sorry, Sebastian"]]), and lone elevator ride down where he processes these new emotions of sadness, regret, rage, and fear. You've got a very powerful emotional moment.
** The moment preceding it, where Tyrell informs him that [[spoiler:extending his lifespan is impossible.]] [[DespairEventHorizon The dawning look of horror, despair and rage on his face]] as he realizes that [[spoiler: his whole quest has been for nothing, that he is doomed and that he will be unable to save either himself or Pris]] is truly heartwrenching. It's no wonder he [[spoiler: snaps and kills his creator.]]
* Batty's very literal VillainousBreakdown towards the end, when it's implied his body starts shutting down. He strips down to his underwear and pierces his own hand with a nail, likely in a desperate attempt to retain his fleeting sensations by giving himself cold and pain, and later starts laughing and howling like a wolf in his SanitySlippage.
** Although the action itself is a CrowningMomentOfHeartwarming, [[spoiler:Roy saving Deckard from falling off the roof]] is an act of empathy ultimately originated in sadness. It's only after discovering his quest was all for nothing and he is condemned to die in minutes that Roy acknowledges [[spoiler:Deckard]]'s situation as just like his own when he sees him hanging off the balustrade: a man desperately struggling to keep grasp of his life, yet slowly and hopelessly sliding down towards the inevitable death.
* Roy Batty's famous soliloquy at the end is very poignant.
-->'''Roy:''' I've... ''seen'' things you people wouldn't believe. Attack ships on fire off the shoulder of Orion. I watched C-beams glitter in the dark near the Tannhäuser Gate. All those... moments... will be lost in time, like tears... in... rain. Time... to die...
** The mournful electric piano music that plays over the scene adds greatly to the mood.
** Creator/RutgerHauer [[ActorInspiredElement improvised Batty's soliloquy]] after finding Batty's original dying words in the screenplay to be unsatisfactory. It is said that his performance of the scene was so genuinely powerful and moving that several crew members applauded and some actually started weeping, making this a RealLife TearJerker as well.
* Roy tearing up over Pris' corpse and giving her one final kiss after Deckard shoots her dead.
* When Gaff confronts Deckard on the roof. It really drove home the point (in the Director's Cut, anyway) that [[spoiler:Deckard may be a replicant]] and what that means for him and Rachael.
-->'''Gaff:''' It's too bad [[spoiler:she won't live]]! But then again, who does?
* The poor replicants had just discovered love when they (somehow) found out that they'd been constructed with a [[spoiler:four year life expectancy]].
-->'''Leon:''' Painful to live in fear, isn't it?