* [[spoiler: Yoshimo's death. Just as bad is the barrage of [[WhatTheHellHero sad]] [[WeUsedToBeFriends and]] [[EtTuBrute betrayed]]-sounding comments from your companions that precede it.]]
* Farmer Brun's Missing Son. Elderly Farmer Brun asks you to look for his son, Nathan, who went to investigate missing livestock. You go to look for him in the Ankheg's Nest and after fighting your way through Ankhegs, you find his body. You can't take him to get resurrected, he's gone for good. You take him back to his father, who is heartbroken, as he lost not only his son, but will lose his land as well, as he is now too feeble to work. That is unless you choose to give him 100 gold pieces to help him get by. Still, he lost his only son, and will be alone.
* Jon Irenicus's speech to [[spoiler: Ellesime]] at the Tree of Life helped to humanise and add tragedy to a character who up until that point had been an unrepentant, sadistic MagnificentBastard.
--->I... I do not remember your love, [[spoiler: Ellesime]]. I have tried to. I have tried to recreate it, to spark it anew in my memory. But it is gone... a hollow, dead thing. For years, I clung to the memory of it. Then the memory of the memory. And then nothing. The Seldarine took that from me, too. I look upon you and I feel nothing. I remember nothing but you turning your back on me, along with all the others. Once my thirst for power was everything. And now I hunger only for revenge. And... I... Will... HAVE IT!!
* At the end of ''VideoGame/ThroneOfBhaal'', if you're in a relationship with Jaheira, her reaction to whichever decision you make is worthy of the name TearJerker.
* The ending WhereAreTheyNow stories for party members are often quite TearJerker-y. At least, Minsc's "they're together still, up among the stars where hamsters are giants and men become legend". Viconia's [[spoiler:romanced ending where her past finally catches up with her and she is denied even the experience of seeing her son grow up by the ever-scheming Lolth and her followers]] is also liable to make your eyes water.
** Kelsey's romance mod can make players tear up every time. Not helped by the almost sobbing of the voice actor.
*** Kelsey. Tree Of Life. "So let me just say this. I love you. I need you. And I am with you until the end." It's voiced. Cue waterworks!
* The Master Wraith in ''Throne of Bhaal'' WILL [[BreakTheCutie tear up]] your romance option, but none came close to utter heartbreaking like Aerie. To wit: [[spoiler:he conjured an image of her mother, who proceeds to blame her for getting the latter killed by more sadistic slavers, all because Aerie ''dared'' to go missing from her]]. Aerie may be a little too whiny for her own good, but on the other hand, hearing her completely break down sobbing and begging it to stop is just too much.
** Even worse, when it's the other original romance options doing these things, the only things voiced are [[spoiler:the illusions of their loved ones]], the victim does not have voice acting. Aerie? Her whole breakdown is ''voiced'', so you get to hear Creator/KathSoucie making her sound completely desperate and in anguish, and ''goddammit it was that effective'' to show the trope BreakTheCutie.
* In the ''Tales of the Sword Coast'' expansion for the original game, the resolution of the Werewolf Island subquest is rather tragic. There is one particular character -- the friendliest one in the village and pretty much the only one who doesn't hold your outsider status against you -- who you can do favors for such as retrieving a cloak and delivering him/her (depending on your player character's gender) flowers. If you pick the nicer dialogue options, the journal entries reveal that you are becoming increasingly fond of him/her. If you offer to take him/her with you to the mainland to start a new life together, he/she will consider it but ultimately refuse out of fear and lingering attachment to the village. That's sad enough. After TheReveal [[spoiler:that the villagers are all dangerous werewolves]], he/she helps you to evade them and shows you an escape route. Your new friend and nascent LoveInterest still refuses to leave and decides to fight the other villagers to buy time for you -- and it's heavily implied he/she doesn't survive. The journal entry covering this ends with the words "...I wish..."
** There is, however, a mod in the works which will allow said villager to join your party in the second game (and even become a full fledged LoveInterest). So a nice Fan Retcon on what would otherwise have been quite a DownerEnding.
* Many Bhaalspawns in Saradush don't want anything to do with their heritage and just want to go on with their lives. It's also heavily implied that Bhaalspawns will end up in the lower planes when they die, regardless of alignment and by all accounts, [[spoiler: they all die when Saradush is destroyed.]]
** Speaking of Saradush, delving into Yaga-Shura's backstory is something of a tear jerker all of its own; not because it makes him any less of a monster - if anything it just makes him worse - but meeting his adoptive mother Nyalee is a pretty tragic experience. She explains to you that in life, she was a priestess of Bhaal who adopted Yaga-Shura in infancy. Although Bhaal would have wanted her to kill him as a baby, she raised him as best she could and even helped him achieve invulnerability by cutting his own heart out and placing it in a SoulJar. He then did the same to her to prevent her from undoing her work; this comes back to bite him on the ass in a big, big way when her shade is only too happy to help you render him vulnerable in exchange for the return of her own. The tissue-wiping starts when she restores her own heart and remembers her emotions, including her lost love for the giant she raised as if he came from her own womb...
-->"''And... there. It be done, a simple thing, it is. The boy's heart is cold, now. As... as cold as his mother's old heart... You... you will hurts my boy, won't you? No... [[MyGodWhatHaveIDone no, what has Nyalee done?!]] My poor boy, the spawn-child will hurts him! Nyalee must stops him/her!! Come, spirits of the glade! Come, woodsies of the forest!! We... [[MamaBear we must protects my boy! My precious Yaga-Shura!!]]''"
* Jaheira finding [[spoiler: Khalid's corpse]] at the beginning of Baldur's gate 2. This is the first time the rather stoic Jaheira breaks down crying. And even if you consider him TheScrappy, it's rather hard to not break down.
* A short line from Imoen, after the revelation of her [[spoiler: Bhaalspawn]] status.
--> ''Imoen:'' I don't feel like I fit in with the people of the city anymore.
* Brage, former captain of the Amnish guard and an all around decent guy -- until he obtains a cursed sword of berserking. The curse drives him to kill his entire family, a merchant caravan (both people and horses), and who knows how many other people in between by the time you catch up to him. If you choose to return him to the Temple of Helm, Brage will be horrified by what he's done (even though he couldn't control it) and say that he no longer wants to live. Nalin, the priest, instead insists he atone for it all. Try talking to Brage after he comes to his senses and you're met with a mix of insane laughter and distraught sobbing.
* Viconia's ending if romanced. It's such a downer that the above-mentioned Edwin romance mod comes with a happier ending for a romanced Viconia thrown in, though it only triggers if the player "redeems her" and causes her CharacterAlignment to shift to TrueNeutral.
* Rasaad's endings; all three. No matter what comes, he dies in ignominy, whatever happiness he enjoyed ending with a miserable death. And no matter what happens, Alorgoth gets off scot-free, the vengeance that defined and shaped Rasaad's CharacterDevelopment left unfulfilled.
* Durlag's Tower... just the backstory of Durlag's Tower. A dwarven hero builds this home for treasures and family in the late days of his adventures, and then it gets infiltrated by Doppelgangers whom systematically murder his entire clan until only he remains. Then Durlag goes made after slaughtering them because they ''still wore his family's faces''!