* Mike's HeroicBSOD [[spoiler: if you fail to rescue Madison.]]
--->[[spoiler: '''Marburg:''' Or people you care about will start to die.]]
--->[[spoiler: '''Madison:''' Mike! Mike!]]
--->[[spoiler: ''(echoing gunshot)'']]
* If [[spoiler:Madison is killed and Mike knows that she's Alan Parker's daughter, then Mike can tell Parker that Marburg killed his only daughter]]. It's the only time Parker doesn't show an emotion that's either a smirk or unemotional crotchetiness - instead, his face collapses in genuine grief, before he tells Mike to go away.
* Killing Sis aboard the yacht, because on the news after her death, she gets mistaken for a prostitute and the newscasters speculate that she might have been lured aboard the yacht by a wealthy owner for the purposes of making a "snuff film".
* Mike leaving his PDA in a phone booth before he surrenders to Darcy, especially if he has a positive relationship to Mina. If he has a positive relationship with Darcy, the latter looks and sounds defeated, because he knows Mike will be executed.
* [[spoiler:Mina]]'s death, whether you don't rescue her or kill her yourself (YouBastard).