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* Kaileena from ''VideoGame/PrinceOfPersiaWarriorWithin'' plays a pivotal character and the main antagonist in the game who is spared by the Prince at the end of the true (hidden) ending... only to be killed off within the first 15 to 20 minutes of the third game in the series, ''VideoGame/PrinceOfPersiaTheTwoThrones''. Subverted in that [[spoiler: she continues to narrate the game after her "death", and is ultimately restored to her true form once the Prince defeats the Vizier.]]
* Simone Taylor was one of three characters to survive ''5 Days a Stranger'', the first game of the VideoGame/ChzoMythos. (The second character would come down with a case of ChuckCunninghamSyndrome shortly afterward, and the third was the player.) The second game, ''7 Days a Skeptic'', is set in the distant future, and the player finds a letter that mentions, among other things, that Simone was killed very shortly after the events of ''5 Days''. The third game, ''Trilby's Notes'', goes back and actually is set very shortly after the events of ''5 Days'' and the prologue/tutorial ends with the discovery of Simone's body.
* Johnny Cage is killed off off-screen prior to the events of ''VideoGame/MortalKombat3'', then brought BackFromTheDead in ''4'', Liu Kang is killed off at the start of ''Deadly Alliance'' before being brought back as a zombie later, and a large number of the Earthrealm warriors are killed at the beginning of ''Deception''. They are all brought BackFromTheDead for Armageddon, though.
* Vic Vance is killed in a gun battle mere minutes into ''VideoGame/GrandTheftAutoViceCity'', but later appears in its prequel, ''GrandTheftAutoViceCityStories'' as the protagonist. This trope only works, however, if one plays the games in chronological order.
* In ''VideoGame/GrandTheftAutoV'': in Trevor's introductory cutscene, he walks up to Johnny Klebitz (the lead protagonist of the ''GrandTheftAutoIVTheLostAndDamned'') and, after a short conversation, proceeds to bash the latter's brains in. The mission immediately following this has Trevor massacre all of the surviving members from the Alderney chapter, including Terry Thorpe and Clay Simons. Additionally, Ashley Butler can be killed by Trevor as she's grieving over Johnny's body; if not, she is revealed in a news report to have died during a meth orgy.
* Bottles in ''{{Banjo-Kazooie}}'' serves to teach Banjo and Kazooie new moves. In the opening cutscene of ''Banjo-Tooie'', he gets killed off by Gruntilda, with some LampshadeHanging: "He wasn't the favorite character in ''Banjo-Kazooie'' anyway," Kazooie says. He comes back to life in the end, though.
* Liam Spencer from ''The Getaway''. You don't even know he survived the events of the first game until you find his corpse in the second level of the second game.
* Harry, the protagonist of the first ''SilentHill'' game, is killed in the third (since the second was a standalone story) after being ambushed in his home by a boss-type mook, without his weapons.
* Instead of attempting to RoadCone which girl ends up with the Protagonist from the first SentimentalGraffiti, the second game opens up with the new protagonist meeting all of the girls at the first's ''funeral'' (he died of a [[BusCrash car accident]]).
* In ''{{Killzone}} 2'', the heroes of the original ''Killzone'' all appear as OlderAndWiser [=NPCs=] helping the new player character Sev, until they all end up getting killed over the course of the game. ''Killzone 3'' confirms that only Rico survived.
* Brad Vickers survives the events of the first ''VideoGame/ResidentEvil'', only to make a hidden cameo in ''VideoGame/ResidentEvil2'' as an overpowered zombie who carries with him the key to the wardrobe locker. In the beginning of ''VideoGame/ResidentEvil3Nemesis'', it turns out that Brad was hunted down and killed by the Nemesis a day before the events of the previous game.
** Both Jill Valentine and [[NighInvulnerable Albert]] [[BigBad Wesker]] were [[spoiler: [[SubvertedTrope falsely presumed]]]] dead for two years in ''VideoGame/ResidentEvil5'', after she [[HeroicSacrifice tackled him over a cliff]].
* 16 possible party members from the first ''BaldursGate'' game who make an appearance of sorts as [=NPCs=] in the sequel. Five are party-joinable members: of the rest, over half end up dead. Of particular note are Dynaheir and Khalid, who are killed off shortly before the game even begins - this being of import because the sequel assumes they were in your party at the end of the first game (which is highly likely assuming you played a Good alignment and met them early on in the main questline: the "canonical" party includes them and their respective partners Minsc and Jaheira, both party-joinable but newly single in the sequel, and Imoen who turns out to be [[spoiler: your sister]], and makes major plot points out of all of these events.) Of the rest: Faldorn ends up as an evil sidequest boss you have to kill, Montaron and Xzar both die (one onstage, one offstage) as a result of Harper/Zhentarim factional bickering, Ajantis is killed by your own party while both of you are under an illusion spell and you don't even get to learn his identity unless you have a paladin or knight in your own party, Tiax dies in a battle in the asylum, Safana is killed by werewolves in a battle which Coran will probably also die unless the players [[CurbStompBattle win the fight fast enough]]. With Viconia and Edwin also being party-joinable, only Quayle and Garrick actually survive their appearance as non-joinable [=NPCs=]
* Master Miller was one of Solid Snake's radio support crew in ''VideoGame/MetalGear2''. In the sequel, ''VideoGame/MetalGearSolid'', Miller gets killed off-screen and impersonated by Solid's evil twin, Liquid Snake, a fact that isn't even revealed until it is casually mentioned just when Liquid is done with the ruse.
** Naomi made it through ''MGS'' relatively intact, and was just about the only villainous character to be redeemed instead of killed or arrested. In ''VideoGame/MetalGearSolid 4'', she dies of spontaneous magical [[{{Nanomachines}} nano]]cancer from nowhere [[DroppedABridgeOnHim for no real plot reason]] other than to [[StuffedIntoTheFridge make Otacon cry]]. Overlaps with StrangledByTheRedString, since Otacon had never even met her until this game.
** ''[=MGS4=]'' also kills off two rather important characters from ''VideoGame/MetalGearSolid3'', namely Para-Medic and Mr. Sigint, by retroactively establishing that they were actually DARPA Chief Donald Anderson and Dr. Clark, two characters who were killed off in the original ''MGS''. While a case could be made that Sigint was always meant to be a younger DARPA Chief (since the ending of ''[=MGS3=]'' establishes that Sigint later became a DARPA employee), the decision to reveal that Para-Medic was Dr. Clark was a bit more questionable. Aside from the fact that Dr. Clark never even appeared on-screen in ''MGS'' (being killed off two years prior to the events of the game), Dr. Clark was originally referred by male pronouns in the game, whereas Para-Medic is female. The attempted HandWave that the person who referred to her as a male never met her in person only serves to slightly disguise the blatant RetCon.
*** This it actually not a RetCon, but rather the result of a translation error. Japanese does not use differentiated male/female pronouns often, and Dr Clark is apparently only described gender-neutrally in the original Japanese dialogue of MGS1. The HandWave about Naomi never meeting her is something of a half-hearted cover for it - the truth is that the idea of a male Dr Clark was apparently an incorrect assumption by the English translation team.
* In ''VideoGame/DoubleDragon'', Billy and Jimmy Lee spent the entirety of the game trying to rescue their friend Marian from the Black Warriors. In the sequel, ''Double Dragon II: The Revenge'', she gets gunned down at the start of the game by the gang's leader, rendering the whole point of its predecessor moot.
** She does [[BackFromTheDead come back]] [[DisneyDeath to life]] in the NES version though.
* Irene Lew falls seemingly to her death from a cliff after being chased by Ryu Hayabusa's [[EvilTwin evil doppelganger]] in the opening sequence of ''[[NinjaGaiden Ninja Gaiden III]]''. However, it later turns out that she survived her fall and was [[HesJustHiding really hiding]] from her adversaries.
** The manual hints that the events of ''Ninja Gaiden III'' occurs [[{{interquel}} sometime between the previous two games]], which makes Irene's survival a bit less surprising to anyone who reads between the lines -- as does the fact that Ryu still has the Dragon Sword, which he lost at the end of ''II''.
* After surviving the events of ''ObsCure'', Kenny gets killed in the sequel -- in the most drawn-out, painful way possible, involving a FaceHeelTurn. Oh, and the other two heroes who don't return are eventually implied to have been horribly killed off-screen.
* ''VideoGame/ChronoCross'' introduces a computer AI, reveals it to be Robo's AI transplanted into a computer by Lucca, and then unceremoniously deletes the AI in a single text dump, accomplishing nothing except shock value.
** Most of the cast in ''VideoGame/ChronoTrigger'' were killed offscreen, missing in action, or erased from existence before ''VideoGame/ChronoCross'' even begins.
*** Crono and Marle presumably died when Guardia fell, Lucca is killed by Lynx and Harle, Frog/the original Glenn probably dies a natural death, Ayla isn't even ''born yet'', (as you can play as her implied mother when she was a child, sent to the present through a gate), and Robo is killed onscreen. The only character who is still alive is Magus, who is heavily implied to be Guile who erased his memories.
* ''VideoGame/WingCommander'' loves these:
** ''Wing Commander II'' - The Tiger's Claw is destroyed in the intro sequence, killing many of the characters from the first game (eg. Halcyon, Shotglass).
** ''Wing Commander III'' - Similar to the above, the Concordia from Wing Commander II is seen crashed on a planet. Also, Angel is executed by the Kilrathi as part of the opening sequence, though the full scene isn't shown until later.
*** There's also Hobbes' FaceHeelTurn, leading to his death.
** ''Wing Commander IV'' - Vagabond is killed a short way into the game.
*** Averted, however, with the TCS ''Victory'', which is said by Maniac to have been made into a museum.
** ''Wing Commander Prophecy'' - Christopher Blair is missing in action/presumed dead by the end of the first act, but then recovered, only to be missing in action/presumed dead again by the end of the game.
*** And Hawk is killed, a little after halfway through.
* ''FireEmblem'' has an amusing inversion of this trope. In ''The Sword of Flame'', the seventh game, a character called Canas exists and is said to be the son of the semi-legendary mountain hermit as well as the father of her grandson. ''Sword of Flame'' is a prequel to [[NoExportForYou the sixth]], ''The Sword of Seal'', and Canas does not appear. To explain this Canas's ending has him die in a blizzard, resulting in the meme that "Canas was killed by continuity errors".
** Hector suffers from this, as a character who is captured and killed early in ''Sword of Seals''. His and Eliwood's wife are both said to be dead. Nino and/or Jaffar were likely killed while on the run. Karla is dead as well. Lucius goes on to run a small orphanage... only to be killed by the invading Bern army, Sue only has concern if her grandfather is alive, not her father (Rath). Sheesh.
** Lorenz in ''Mystery of the Emblem'' wasn't just killed off near the start. He was Chapter 1's boss.
* In ''[[VideoGame/{{Diablo}} Diablo II]]'', the helpful townsfolk from the first game are skeletal scenery when you return to Tristram... except for Deckard Cain, of course, and poor Griswold, who is now the zombie Level Boss. On the plus side, Peg-Leg Wirt's body yields a buttload of coin and a surprising magic item.
** Even better example? The Rogue is corrupted by Andariel and becomes Blood Raven, the Sorcerer goes insane and becomes the Summoner, the imposter sub-boss of Act 2; and the Warrior becomes the Dark Wanderer -- the new host of Diablo himself.
** Most of the cast of Diablo II is either dead or insane come ''VideoGame/DiabloIII'', including Warriv, everyone in the city of Harrogath, and the Sorceress (who was killed by the Assassin). And Deckard Cain himself, who survived the first two games, dies early on in the game.
* Mujari and possibly Teresa and Logan die in SyphonFilter: ''Logan's Shadow''. Since Sony has officially abandoned the series, we will never see it resolved. Alima Haddad, the chopper pilot who first appeared in ''Omega Strain'', also dies.
* In Neverwinter Nights 2, between the Original Campaign and Mask Of The Betrayer, many of the main character's companions are killed off when they seemed to be in sight of safety. All characters who weren't killed in the final battle were making their escape, but most of them are killed. The ones that survive are decided by how the player answers certain questions in the expansion.
* In ''VideoGame/MassEffect2'', Navigator Pressly is killed during the opening sequence when the Normandy is attacked by the Collectors. Commander Shepard also dies, [[BackFromTheDead but is revived two years later]]...and given a new Normandy into the bargain.
** Inverted with Wrex, the Council and Kaidan or Ashley, all of whom were significant characters in #1. Since their deaths are optional, they're written into much smaller roles in #2.
** The third game promises to allow you to resolve all those story arcs continuing them from wherever you left them in the first, their lack of interactive progression in the second game is to keep the amount of possibilities ''in the 4 digit range''. Expect the rest of the first game as well as the returning Mass Effect 2 cast to once again be susceptible to AnyoneCanDie.
*** And indeed, there's exactly ''one'' main character who is completely without a potential PlotlineDeath in the entire series, and therefore not susceptible to this trope: [[spoiler:Joker, who can only die via NonstandardGameOver in the second game during the brief period the player controls him]]. [[spoiler: Liara]] almost counts, as she can only die towards the very end of the game if your Military Strength is too low.
** Executor Pallin (the top cop of C-Sec) was absent in the second game, with his role mostly taken by newcomer Captain Bailey. Pallin is later killed off in a comic book sidestory...by Captain Bailey.
* The downloadable content for ''Left 4 Dead 2'' ("The Passing") reveals that Bill sacrificed himself to save the survivors of the original ''Left 4 Dead'' before they met the cast of the sequel.
* The normal ending of ''FatalFrame 3'' heavily implies that Mio from the second game fell victim to the curse.
* Samantha Clarke in ''[[VideoGame/SupremeCommander Supreme Commander: Forged Alliance]]''. She dies in the opening cinematic before you can even create your profile.
* Orthopox-13 in ''DestroyAllHumans 2''. To be fair, [[MissionControl he didn't confront]] [[VoiceWithAnInternetConnection much of the action]] in the first game, but it says something that he was '''''nuked in space''''' in the intro to the sequel; in fact, the crashing debris of the mothership is what creates the setting for the prologue. [[BrainUploading He does get better fairly quickly, though.]]
* In ''VideoGame/AssassinsCreedBrotherhood'', Ezio's Uncle Mario is killed off in the first half hour.
* Johnny Gat is offed before the end of the second mission, in ''SaintsRow:'' The Third. [[spoiler: [[SubvertedTrope Subverted]] in IV, when it's revealed that he was abducted by Zinyak instead...apparently, Gat was so badass that he felt it was necessary to take him out of the picture ''years'' before he was ready to invade Earth.]]
** Then, in [[VideoGame/SaintsRowIV Saints Row IV]], Oleg and Josh are killed when Zinyak [[EarthShatteringKaboom destroys the Earth]]. Naturally, it can probably be assumed that everyone else who didn't get put into the simulator met the same fate, though those two are the only ones specifically shown when it happens.
** Before either of these, in VideoGame/SaintsRow2, Aisha gets beheaded by Jyunichi after faking her death in the first game.
* In ''ModernWarfare 3'', Griffin (the sergeant who assisted you in the ''[=MW1=]'' mission "Crew Expendable"), Russian loyalist Sgt. Kamarov and former main character 'Soap' [=MacTavish=] die.
* Most of the Servants' backgrounds and ambitions were explored in the first two routes of VisualNovel/FateStayNight, so come the third, ''Heavens Feel'', almost everyone is killed off quickly in the first few few days. To be particularly [[TVTropesDrinkingGame egregious]], most of the deaths are also rather unceremonious. Lancer, Caster and Assassin get killed off almost immediately and with little to no resistance; Gilgamesh barely gets a word in edgewise; Archer and Berserker are killed/absorbed in their first fights; Saber (though not killed) is beaten early by sheer plot device.
* Helena Pierce suffers this at the very beginning of ''VideoGame/{{Borderlands 2}}'', being killed off-screen and the audio-logs of her death retrievable by the players as a small foretaste of what a SmugSnake Handsome Jack really is.
* Byakuya Togami is this in Super Dangan Ronpa 2. [[spoiler:Subverted outright: He's not actually the Byakuya we know, he's an Elite Class Impostor.]]
* In {{VideoGame/Battlefield4}}, this is the fate of three ''Battlefield 3'' characters: [[spoiler:Hawkins[[note]]the F/A-[=18F=] Super Hornet weapon systems officer, inexplicably now in a helo[[/note]], Dima[[note]]the Russian deuteragonist[[/note]] and Kovic[[note]]turns out that he was "Agent W.", the 'bad cop' interrogator, during Blackburn's interrogation[[/note]]]], although [[spoiler:Dima]] is the only one whose history in the prior game is referenced at all.
* Detective Bravura was a HeroAntagonist in the first ''VideoGame/MaxPayne'', and DaChief in the 2nd. He shows up early in the game during a firefight in which Max is ambushed, outnumbered and [[WarringWithoutWeapons unarmed]], appearing just long enough to shout a warning before he's gunned down. It's only technically a subversion that he lived (probably helped that he was shot in a hospital,) since for the rest of the game he's in critical condition, assumed dead any second, and has no further bearing on the plot.
* Telltale Games' ''{{VideoGame/The Walking Dead}}'' kicks off Season Two with [[PluckyComicRelief Omid]], [[PregnantBadass Christa]], and [[TheCutie Clementine]] having somehow reunited after the DownerEnding of Season One. They're in good spirits, they've found shelter, and they're having a chipper conversation about what to name Christa's baby, due soon... [[MoodWhiplash and then Omid is shot by a bandit.]] Poor guy didn't even last ten minutes into the new season. And just for an extra punch to the gut, the baby that Christa was pregnant with back in Season 1? It's never shown, or even discussed after a 16-month TimeSkip.
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