* Huey Freeman of ''TheBoondocks'' had become the straight man of Riley Freeman, Robert "Granddad" Freeman... and even Uncle Ruckus.
* Carey Means, who plays Frylock on ''WesternAnimation/AquaTeenHungerForce'', has the added privilege of playing the Straight Man to lines that usually don't even make sense spoken by anthropomorphic food items and stoned two-dimensional aliens.
* Ditto for Charles Foster Ofdenson, who plays Straight Man to Dethklok and OnlySaneMan to the ''{{Metalocalypse}}'' universe.
* Raffles the border collie from ''RoverDangerfield'' is easygoing and slightly naive compared to the title joker.
* The concept is parodied in the first episode of ''WesternAnimation/TinyToonAdventures'' when Hampton is being interviewed by Buster and Babs in which he rattles off a list of characteristics of the straight man, presenting them as his own personal qualities.
* Twilight Sparkle is the character in ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' to fill this role most often, thanks to her [[OnlySaneMan Only Sane Mare]] status (except for whenever her [[SuperOCD neuroticism]] [[SanitySlippage gets the better of her sanity]], which usually [[InvertedTrope inverts]] this trope).
** Additionally, Fluttershy and Applejack are usually the ones to play this to whatever character is serving as their comedic {{foil}} at the time, while it is more rare for [[BoisterousBruiser Rainbow Dash]], [[LargeHam Rarity]], and especially [[CloudCuckoolander Pinkie Pie]] to do so. The character dynamics of "Hearth's Warming Eve" are built around the three "straight" characters playing idealized versions of themselves that are paired with the three "funny" characters, whose personality flaws are dialed UpToEleven.
** Cheerilee plays the comic foil to the Cutie Mark Crusaders in "Family Appreciation Day" and "Hearts and Hooves".
* Ulrich of ''CodeLyoko'' often plays the Straight Man to Odd's antics.
* [[spoiler:Puck]] of ''WesternAnimation/{{Gargoyles}}'' said of his [[spoiler:Owen]] persona, "The Trickster has played many roles, but [[AccidentalInnuendo never that of the straight man]]."
** The fangirls immediately [[HoYay latched on that one]].
* Brian of ''WesternAnimation/FamilyGuy'' infamy started out as a simple foil for Peter and/or Stewie's wackyness. The evolution of Brian's character gives us an interesting case study in exactly what level of CharacterDevelopment is appropriate for these types. If all they ever do episode after episode is set up other character's jokes and snark at their buffoonery, you run the risk of having a FlatCharacter. Going too far in the other direction, though, takes us into [[{{Anvilicious}} much]] [[AuthorAvatar more]] [[MarySue malignant]] [[AuthorFilibuster territory]], as giving too much exposure to a character whose main purpose is appearing more sensible and intelligent than others will eventually necessitate the writers revealing their own prejudices about just what they think an intelligent or sensible way of life is.
* In ''WesternAnimation/TheSimpsons'', Lisa has the thankless task of playing foil to ''her entire town''. In the early days she and Bart were a classic StraightManAndWiseGuy combo, and while this is still true, she often finds herself playing straight to almost everyone else in Springfield. Luckily, she is usually excellent at it. Occasionally, especially in later seasons, Lisa's more extreme personality traits will come to the fore and she gets to have someone else play off her for a change.
** Lisa was in danger of falling into the same trap as Brian (see above) in later seasons, as she began to turn into a SoapboxSadie. In more recent years the writers have dialed her back to her earlier, more sensible persona; she hardly ever mentions politics anymore, and she has once again become the straight man.
* Stan Marsh from ''WesternAnimation/SouthPark'' is the Straight Man to the WHOLE town in later seasons.
** While Stan is probably the "straightest" character, others exist too. Kyle is Straight Man almost as much as Stan, especially compared to Cartman. Sharon will often play Straight Woman to her [[CloserToEarth less sane]] husband Randy. And in general, kids are often the Straight Boys and Girls [[AdultsAreUseless to the town's idiot adults]], though at times the Mayor will do this too (despite at other times being an AuthorityInNameOnly or be just as stupid as them).
*** The premise of the entire show basically boils down to the idea that all kids are straight men to adults: they stand on the sidelines and comment with bewilderment on the insanity that is the adult world.
* WesternAnimation/KimPossible is a laser focused StraightMan to her {{sidekick}} Ron, both comedically and in the action/adventure scenes.
* On ''InvaderZim'', [[VillainProtagonist Zim's]] insanity is usually contrasted to [[HeroAntagonist Dib]], though his base's supercomputer or even ''[[CloudCuckooLander GIR]]'' can play this role in a pinch. In general, though, everyone will play this to everyone else at some time or another, because they're ''all'' at least slightly insane.
** When Dib needs to be the [[YouHaveToBelieveMe insane one]] when trying to warn everyone about Zim, his sister [[EnfantTerrible Gaz]] provides the foil.
*** Both of them regularly foil their mad scientist father whenever he comes up with a new invention.
* {{Jimmy Two-Shoes}} is usually this to the other characters, acting fairly normal ([[ThePollyanna for him]]) so that [[TheHedonist Beezy]], [[EnfantTerrible Heloise]], or [[TheCaligula Lucius]] can play off of him.
* ClassicDisneyShorts have a trio composed of two comedic characters, the [[TheChewToy unlucky]] and [[HairTriggerTemper irritable]] DonaldDuck, and the clumsy and sometimes stupid {{Goofy}}... and the everyman MickeyMouse.
* Ever since soon after he was created, it has been customary to pair DaffyDuck with a Straight Man -- usually PorkyPig, who has been the go-to straight man for ''WesternAnimation/LooneyTunes'' ever since ''his'' creation years earlier -- but later on BugsBunny occasionally played straight man to his then more abrasive personality.
** Much like his ''WesternAnimation/LooneyTunes'' predecessor, Hamton Pig in ''WesternAnimation/TinyToonAdventures'' often plays this role, often, again, to Daffy's counterpart Plucky, though one notable plot played ''Plucky'' as suffering straight man to ''Hamton'''s ridiculously nuclear family.
* On ''WesternAnimation/PhineasAndFerb'', Perry's ''voicelessness'' puts him in the straight man position to Doofenshmirtz (and, to a lesser extent, Major Monogram).
** And, of course, Linda, despite her own goofy moments, plays the perfect straight woman to Candance's obsessive craziness. Of course, it's the straight woman attitude that is causing a lot of that craziness...
* Patricia of ''{{Spliced}}'' generally functions as the straight woman to Peri, Entree, and Joe's craziness, though Peri fills in when she's not around.
** Octocat also is this to Smarty-Smarts.
* ''WesternAnimation/NedsNewt'': Ned serves this role to the rather chaotic and random Newton the newt.
* Tommy Anybody serves as this to ''WesternAnimation/MrBogus''.
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