* ''WesternAnimation/GuardiansOfLuna'' to ''WesternAnimation/{{Gargoyles}}''
* ''MickeyMouse'' to ''OswaldTheLuckyRabbit'': After losing Oswald to his distributor, Walt Disney created a new series of cartoons around a new character, Mickey, who was pretty much Oswald where the primary difference being that Walt Disney owned full legal rights to Mickey.
* ''WesternAnimation/HomeMovies'' to ''DrKatz'', with both shows employing the so-called "Squigglevision" animation (though ''HomeMovies'' dropped it in its later seasons).
** ''WesternAnimation/BobsBurgers'' to ''WesternAnimation/HomeMovies''.
* ''WesternAnimation/{{Futurama}}'' to ''WesternAnimation/TheSimpsons''.
* ''WesternAnimation/AmericanDad'' to ''WesternAnimation/FamilyGuy'' before the latter was renewed. It started out as the political version of the show, but many people believe that ''American Dad'' is the spiritual successor to the first three seasons of ''Family Guy'', since the show became largely different after being uncancelled.
** Similarly, ''American Dad'' can be viewed as a spiritual successor to ''WesternAnimation/SouthPark'' (Before Season 12, at least), because both shows went through an evolution process and their later episodes are often thought to be better than their old.
* ''WesternAnimation/CampLazlo'' and ''WesternAnimation/SpongebobSquarepants'' to ''WesternAnimation/RockosModernLife''.
* ''WesternAnimation/TheJetsons'' to ''WesternAnimation/TheFlintstones''. There's also the much more obscure series ''The Roman Holidays''.
* ''WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius'' can be considered this to ''WesternAnimation/DextersLaboratory''
* ''WesternAnimation/MyLifeAsATeenageRobot'' to ''WesternAnimation/WhateverHappenedToRobotJones''
* ''WesternAnimation/{{Animaniacs}}'' was more or less a continuation of ''WesternAnimation/TinyToonAdventures'' with a new cast of AnimatedActors.
** ''WesternAnimation/TinyToonAdventures'' to both ''WesternAnimation/LooneyTunes'' and ''WesternAnimation/APupNamedScoobyDoo'' (which was the last project most of the WBA staff worked on together at Hanna-Barbera).
** Within ''WesternAnimation/LooneyTunes'' itself, the short ''WesternAnimation/RabbitRampage'' could be considered the Spiritual Successor of ''WesternAnimation/DuckAmuk''.
* It might be a stretch, since one is animated and the other wasn't, but ''WesternAnimation/BatmanTheBraveAndTheBold'' often feels like the SpiritualSuccessor to the '60s ''Series/{{Batman}}''.
** It is without a doubt a SpiritualSuccessor. And in the show, TheMusicMeister is a direct SpiritualSuccessor to ''WebVideo/DoctorHorriblesSingAlongBlog''.
* ''WesternAnimation/AroundTheWorldWithWillyFog'' is a FunnyAnimal spiritual successor to the Australian cartoon ''WesternAnimation/AroundTheWorldInEightyDays''. Considering both are based on [[Literature/AroundTheWorldInEightyDays the original book by]] JulesVerne, this should come as no surprise.
* ''WesternAnimation/AdventureTime'' (and to a lesser extent ''WesternAnimation/RegularShow'', ''WesternAnimation/GravityFalls'' and ''WesternAnimation/SanjayAndCraig'') to ''WesternAnimation/TheMarvelousMisadventuresOfFlapjack''.
** And ''Flapjack'' is one to ''WesternAnimation/TheGrimAdventuresOfBillyAndMandy''.
*** ''WesternAnimation/AdventureTime'' is considered by many people to be the spiritual successor to the first 3 seasons of SpongeBobSquarePants, as it shares many of the same writers and creativity as those seasons.
* ''WesternAnimation/LoonaticsUnleashed'' to ''WesternAnimation/RoadRovers'' . Both are action cartoons with some comedy elements based on futuristic anthropomorphic superheroes, and are both made by Warner Bros. [[{{Expy}} Also, there's a number of character similarities.]]
* ''WesternAnimation/TheBoondocks'' is sometimes said to be this to ''WesternAnimation/{{Coonskin}}''.
* While ''WesternAnimation/{{Mad}}'' is more of a spinoff to ''Series/{{MADtv}}'', it's somewhat of this trope to ''WesternAnimation/KaBlam'', featuring many of the same staff (mainly a different cast as well, save for June).
* ''WesternAnimation/TheAmazingWorldOfGumball'' to ''WesternAnimation/{{Chowder}}''.
* ''WesternAnimation/UncleGrandpa'' to ''WesternAnimation/SecretMountainFortAwesome'', which is itself a successor to the original Uncle Grandpa short for Cartoonstitute.
* ''WesternAnimation/MoralOrel'' is an ironic- and ''very'' [[BlackComedy dark]]- successor to ''WesternAnimation/DaveyAndGoliath''.
* ''WesternAnimation/LloydInSpace'' and the 2010 reboot of ''[[WesternAnimation/PoundPuppies2010 Pound Puppies]]'' to ''WesternAnimation/{{Recess}}''.
* ''WesternAnimation/FostersHomeForImaginaryFriends'' and ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' to ''WesternAnimation/ThePowerpuffGirls''.
* ''WesternAnimation/MyLittlePonyEquestriaGirlsRainbowRocks'' appears to be one for ''WesternAnimation/{{Jem}}''.
* ''WesternAnimation/DannyPhantom'' to ''WesternAnimation/TheFairlyOddparents''. (The first 3 seasons anyway)
* ''WesternAnimation/TheFlintstones'' to ''Series/TheHoneymooners'', deliberately.
* ''WesternAnimation/InspectorGadget'' to ''Series/GetSmart''.
* ''WesternAnimation/HeyArnold'' can be seen as one to the Creator/{{Nickelodeon}} movie ''HarrietTheSpy''. Both involve kids living in a big city that resembles New York, adventures, eccentric kids in their grade, and eccentric people in the neighborhood. Makes sense, since HeyArnold was a theatrical short when the movie was released.
* ''WesternAnimation/ExoSquad'' to ''Anime/{{Robotech}}''. The viewers weren't the only ones to notice. Creator/PlaymatesToys released a short lived toyline which blended the two.
* Can we start calling ''WesternAnimation/YoungJustice'' the spiritual successor of ''WesternAnimation/TheSpectacularSpiderman''?
** The show can also be considered a spiritual successor to ''WesternAnimation/JusticeLeague''.
** Both can also be seen as spiritual successors to ''Gargoyles'', given Creator/GregWeisman works on them and feature many similar themes and arcs, as well as references to the former.
* ''Gargoyles'' to ''WesternAnimation/AdventuresOfTheGummiBears''. Gargoyles was even originally intended to be a comedic spin-off of the earlier show, before it was retooled to its more serious, arc-driven form.
* ''WesternAnimation/KiddVideo'' could be TheEighties incarnation of ''WesternAnimation/YellowSubmarine''. for a lot more reasons than the Kiddmobile just happening to be yellow.
* In terms of role, ''WesternAnimation/PhineasAndFerb'' could be considered this to ''WesternAnimation/KimPossible''. Both were among the most successful Disney animated shows of the millennium, with its lampshade-heavy humor and similar tone at certain points.
** Before the SeasonalRot and infamous "2012 Hate Dumb", the show was considered a spiritual successor to the first three seasons of SpongeBobSquarePants.
* ''Bumble's Bucket'' is very much is this to ''WesternAnimation/TheDreamstone'', with a very similar dynamic, tone and even most of the characters [[{{Expy}} resembling those of the previous show]]. Both were projects created by Mike Jupp and Martin Gates Productions, meaning a good amount of the same people worked on both series.
* ''WesternAnimation/TeenageMutantNinjaTurtles2012'' shares much of the aesthetic qualities, storyline aspects, and humor as ''WesternAnimation/TeenTitans'', another series that Ciro Nieli executive produced, down to having at least [[KnightOfCerebus one villain that's darker than the rest]].
* RobotChicken may qualify as a ''very'' [[DarkerAndEdgier dark]] spiritual successor to TheFarSide.
* ''WesternAnimation/TheVentureBrothers'' to ''WesternAnimation/TheTick.'' They share a creator/writer (Jackson Publick), an actor/voice actor (Patrick Warburton), and numerous themes (including various genre [[{{Deconstruction}} deconstructions]].) Tick creator Ben Edlund is also the only person to write an episode (''íViva los Muertos!'') of the Venture Brothers outside of creators Publick and Doc Hammer.
* GravityFalls to Phineas and Ferb despite their FandomRivalry, as Gravity Falls shares similar humor, characters and atmosphere to the latter (albeit darker in humor).
* ''WesternAnimation/GeneratorRex'' to the first ''WesternAnimation/BenTen'' series.
* ''WesternAnimation/TheBookOfLife'' to ''WesternAnimation/ElTigre'': same creators, same theme of a family with generations of awesome, same theme of loving, respecting, and remembering the dead.
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