* ''Webcomic/GunnerkriggCourt'': Chapter 10 - "Dr. Disaster Versus the Creepy Space Aliens from Outer Space". The main UrbanFantasy plot took a break for a comedic RaygunGothic interlude--though not without some character development.
** There are also some unusual interludes following the end of each print volume. The first was followed by {{Guest Strip}}s and letters between the characters; the second was followed by ''City Face'', a short and bizarre story about talking pigeons, which was so popular it got a sequel in the next volume. Though not part of the comic proper, [[WordOfGod Tom has said]] that most of these materials are {{canon}}. [[MindScrew Somehow]].
** There's also the "Annie watches Kat play [[VideoGame/GrandTheftAuto GTA]]" comic, the "Kat melodramatically plays [[VideoGame/MetalGearSolid MGS]]" episode, and the similar one where they all watch PrincessMononoke.
** The current holder of the record for most [[FlatWhat Flat Whats]] from the readers however has to be [[http://www.gunnerkrigg.com/archive_page.php?comicID=1093 MORT FUN TIME]].
** Gunnerkrigg Court does occasionally do guest strips...the ones starting [[http://gunnerkrigg.com/?p=1168 here]] are drawn/written ''by the characters themselves!''
* The delightfully campy ''{{Fans}}'' has featured, among other things: A musical arc (with pictures of characters singing and links to the sound files underneath), a story told from the perspective of an FIB agent experimenting with mind control techniques told via his blog, and a story done entirely in chat logs.
* ''Webcomic/SluggyFreelance'' did its fifth-year anniversary in flash animation (no, no voices, just animation).
* Explicitly used in [[http://www.vgcats.com/comics/?strip_id=129 this strip]] of VGCats.
* Most stories in TheWotch, put the focus on the title character and here two friends, usually including a B story that either focuses on one of the main characters, or, less frequently, a minor side character (like "Moon Over Tandy"). However, "A Girl and her Blob" took a different approach. There is a side story about Anne and her friends battling Were-creatures and a Mad Wizard, but the central story is on minor character Ming and Myrrh, a blob-like woman Ming discovers and bonds with.
* The Intermission between the third and fourth acts of ''Webcomic/{{Homestuck}}'' drops the main storyline completely and shows a storyline involving alternate universe counterparts of some of our characters, who have (in this new story) formed a gang called the Midnight Crew. [[spoiler: Their ...behavior becomes a [[ExpendableAlternateUniverse plot point]] later on.]]
* ''Webcomic/TheFan'' has the Sheyleron Saga side story, that is not only completely unrelated the main storyline, it takes place in a completely different universe, yet the author insists on sticking an installment to the end of every single episode, and sometimes, right in the middle of one.
* An intermission comic in Webcomic/TheOrderOfTheStick was done as a parody of the old "Let's Go Out to the Lobby" advertisements seen at movie theaters. One group of concession stand snacks is challenged by another, and an epic D&D style battle ensues.
* After three lengthy story-arcs, ''NatureOfNaturesArt'' went on to... a gag-a-day-style strip called ''Wild Style''. It's an "intermission arc", so to speak.
* John Kossler of ''TheWordWeary'' does this with his non-canon comics... most especially in the GuestStrip he wrote himself and his off-the-wall [[http://wordwearycomic.blogspot.com/2011/12/8-december-2011.html 100th comic celebration.]]
* The comic {{WebComic/Forever16}} does this with the short story "My Super-Soaked Sweet Sixteen", following a girl who is a model for her mother's professional underwater photography. [[http://jbwarner86.deviantart.com/art/My-Super-Soaked-Sweet-16-P1-424467427 Starts here;]]