* "Three Girls and a Monster" features the girls trying, [[CurbStompBattle and failing]], to stop a giant dinosaur-like monster who is [[NighInvulnerability impervious to all of their physical and strategic attacks]]. In the end, Bubbles simply asks nicely for him not to destroy the city, [[BecauseYouWereNiceToMe and he promptly leaves]]. The monster itself is a nod to Geof Darrow's "[[{{Kaiju}} Yellow Taoking]]" from ComicBook/TheBigGuyAndRustyTheBoyRobot.
* "Meet the Beat-Alls" is one long string of [[Music/TheBeatles Beatles]] references.
* Speaking of Music/TheBeatles, the episode entitled "Get Back Jojo".
* Additionally, Him has a very similar voice to the Chief Blue Meanie from ''WesternAnimation/YellowSubmarine'', and according to [[WordOfGod McCracken]], he was a major inspiration on the character.
* "The Powerpuff Girls Rule" makes as many pop culture references as it possibly can in its 30-minute timeslot. Everything from Creator/GeorgeOrwell[[note]]Buttercup has a fantasy where she rules the world with an iron fist; an ImagineSpot shows her giant face on TV screens with the tag "[[{{Pun}} Big Butter Is Watching You]]."[[/note]] to ''VideoGame/MarioKart''[[note]]All the characters have a ''VideoGame/MarioKart''-style kart race at one point[[/note]] gets its fair share of homage.
* "Child Fearing" had the Mayor playing a video game with a character and a HUD that looked suspiciously like those from 3D Zelda titles. The Mayor even ''killed'' ''VideoGame/TheLegendOfZeldaOcarinaOfTime'''s Navi, [[TakeThatScrappy accomplishing something ''[=OoT=]'' fans could only dream of.]]
* The girls' big eyes were inspired by the art of Margaret Keane; Ms. Keane is named after her.
* There's one to ''Film/TwoThousandOneASpaceOdyssey'' in "Coupe D'etat".
-->'''Blossom:''' This isn't very funny. Open the door, KARR!
-->'''KARR:''' ''(close-up on just one of KARR's headlights)'' I'm sorry, Blossom. I'm afraid I can't do that.
:: This is also a reference to KnightRider, which featured a villainous prototype of supercar KITT named KARR.
* "Nuthin' Special"
** When Buttercup shows off all of her powers in an attempt to find one her sisters don't have, she finally yells out "Film/TheMatrix!" and begins to "dodge" backwards in slow-motion.
** One of the people who can't curl his or her tongue is [[Music/{{Kiss}} Gene Simmons]].
* From "Mojo Jonesin'": "[[WesternAnimation/CaptainPlanetAndThePlaneteers Together, you will be a wonderfully diverse and multi-ethnic super hero team, perhaps saving the environment or, whatever.]]"
* "Dream Scheme" has this reference to ''Film/ThePrincessBride''.
-->'''Professor:''' No buts! I mean it!\\
'''Bubbles:''' Anybody want a peanut?
* "See Me, Feel Me, Gnomey"
** The title iis a reference to the recurring "See me, feel me" lyrics from Music/TheWho's ''Music/{{Tommy}}''. Of course, there must have been more inspiration taken from it as well, with one specific example being a SuspiciouslySimilarSong to the opening of "Pinball Wizard" playing when the gnome is granting the girls' wish.
** During the final song, the faces of several villains appear in nine boxes around the screen. "[[Series/TheBradyBunch The baddie bunch! The baddie bunch!]]"
* "Imaginary Fiend" has Blossom thrown into a pile of coats, emerging [[http://www.spscriptorium.com/williewestwood/powerpuff_cartman.jpg dressed as]] [[WesternAnimation/SouthPark Cartman]].
* In the movie, the spices used to create the Powerpuff Girls are revealed to be [[Music/SimonAndGarfunkel parsley, sage, rosemary, and thyme.]]
* The title of the episode "A Very Special Blossom" alludes to the NBC sitcom ''Series/{{Blossom}}'' (starring Mayim Bialik) in which every other episode was a VerySpecialEpisode.
* In "Knock It Off", [[http://25.media.tumblr.com/tumblr_m708fyl7gr1r4zjplo1_500.jpg there were giant robots in a shot]]. One had the head of the Anime/MazingerZ. Another had the head of the [[Manga/GetterRobo getter-1]], the arms of [[Anime/UFORoboGrendizer Grendizer]], and the Mazinger's breast fire thing. The last one was blatantly Series/{{Ultraman}}. Pretty impressive considering their obscurity outside their home country.
* There's a certain scene in the movie with Mojo Jojo holding a newspaper headlining the girl's destruction of Townsville. The back page of the paper has a small poster for a certain [[Music/{{Gorillaz}} ape-based virtual band]] complete with a heading stating that they're headlining Townsville's Music Fest. Cue Troper's head exploding after a second viewing of the film 9 years after watching it in theaters.
* In the comic book "Trick or Beatings", the following exchange occurs as the Powerpuff Girls (and Mojo Jojo) are out trick or treating:
-->'''Buttercup:''' I got a gooey bear!
-->'''Blossom:''' I got a lollipop!
-->'''Bubbles:''' I got a candy bar!
-->'''Mojo Jojo:''' [[ComicStrip/{{Peanuts}} Mojo got a rock.]]
* In "'Twas the Fight Before Christmas", there's a scene near the beginning where Buttercup worries that waiting until the last minute to send her wish list to Santa might mean she won't get her "[[Film/AChristmasStory official Red Ryder carbine-action 200 shot range model air rifle]]".
* In "Jewel of the Aisle", the girls watch a cartoon called ''[[WesternAnimation/BeastMachines Mech-Animals]]''.
* In "Los Dos Mojos", after knocking out Bubbles, who was convinced she was Mojo Jojo, the real Mojo says [[Film/MontyPythonAndTheHolyGrail "One shall be the number of Mojo Jojos in the world, and the number of Mojo Jojos in the world shall be one. Two Mojo Jojos is too many, and three is right out."]]
* In the first Rowdy Ruff Boys episode in Season 1, Bubbles crashes through a window and apologizes to the clerk, [[Series/SesameStreet "sorry about your window Mr. Looper."]] with which the clerk states "Its Hooper!! Hooper!!!".
* In "Collect Her", when the Mayor is trying to determine who the culprit is, one of the name he comes up with is Genndy [=McCracken=]. This is an amalgam of two of the show's main writers, Genndy Tartakovsky and Craig [=McCracken=].
* [=McCracken=] received another shout-out in a subsequent episode in the form of a pirate names Crack [=McCraigan=].
* "Silent Treatment"
** A scene has the girls sitting in a movie theater, [[Series/MysteryScienceTheater3000 positioned at the bottom right of the screen making fun of a movie as it plays.]]
** The movie has caricatures of Creator/CharlieChaplin, Creator/BusterKeaton, and the Keystone Cops.
* [[Franchise/PlanetOfTheApes "Get your paws off me you damn dirty ape!"]]
* In "Boogie Frights", when the Boogie Man eclipses the sun with a giant disco ball, the Powerpuff Girls' final assault on the ball is an almost shot-by-shot remake of the assault on the Death Star in ''Franchise/StarWars [[Film/ANewHope Episode IV]]''.
* An episode called [[Music/TheDoors "Mr. Mojo's Rising"]].
* An episode makes a reference to Franchise/MegaMan, as two police officers ask each other who would win in a fight, Mega Man or Mondo Dude?
* In "Pee Pee G's", the TV news flash graphic is similar to Kermit the Frog's live on the scene skits on "Sesame Street".
* In "Octi-Gone", the professor receives a call from Mojo Jojo, who claims that he's holding Octi ransom for 1000 barrels of Chemical X. The professor asks the operator to trace the call... who reveals that the call is coming from [[Film/WhenAStrangerCalls inside the house]].
* In "Bubblevicious," Bubbles faces a torture device that goes UpToEleven.
* In "Seed No Evil" a museum tour guide tells the Pokey Oaks class about a caveman frozen in ice. He then says he is going to show them [[WesternAnimation/TheFlintstones how primitive man used wooly mammoths for dishwashers and pterodactyls for record players]].
* In "Something's a Ms.", the Mayor reenacts ''Film/TheBigLebowski'''s epically hammy "Strong men also cry" scene when Ms. Bellum is kidnapped. Later in the episode, the girls use a bag full of the Mayor's underwear as a ringer for the demanded ransom money, as Walter did in the movie.
* In "The Mane Event", the villain-of-the-week is a giant sphere with one eye, resembling the Eye of Volger from ''Manga/GiantRobo''.
* The episode "I See a Funny Cartoon in Your Future" pays homage to ''WesternAnimation/RockyAndBullwinkle''.
* In "Shut the Pup Up", a TV screen displays a black and white pixilated image of a woman, comparable to an in-game TV commercial in ''Videogame/AnimalCrossing''.
* "Powerpiff Girls: Dance Pants" features a RhythmGame within the show called "[[VideoGame/DanceDanceRevolution Dance Pants Revolution]]"