[[foldercontrol]]

[[folder:Anime and Manga]]
* The Las Plagas Parasite is basically the same as the ones from ''Manga/{{Parasyte}}'', right down to more mature hosts having blades come out of their heads when they split open from their hosts.
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[[folder:Film and TV]]

* The deadly LaserHallway is taken straight from a similar scene in ''Film/ResidentEvil2002''.
* One of Leon's unlockable bonus weapons is called [[Film/TheProfessional Matilda]].
** This is also a shout-out to ''VideoGame/ResidentEvil2'' as the main gun itself is the [=VP70=] handgun Leon used in that game. You could find the parts to upgrade Leon's handgun to the Matilda, and Hunk had one listed as the Matilda in his inventory in "The 4th Survivor" subplot.
** Another reference to the film: the hardest difficulty setting is "Professional".
** The movie being referenced is ''Leon'' aka ''The Professional''. The main characters of that film are named Leon and Mathilda.
* The [[RevolversAreJustBetter Broken Butterfly]]'s description mentions it will [[Film/SuddenImpact "make anyone's day."]] The Merchant also notes that the Broken Butterfy is "not just about shooting, [[VideoGame/MetalGearSolid it's about reloading]]. You'll know what I'm talking about."
* Ada's pose for "Separate Ways" mirrors the film poster for ''[[http://www.impawards.com/1991/posters/la_femme_nikita_ver1.jpg Nikita]]''
* In Chapter 3-1, after defeating the first Garrador and turning off the flame barrier, three whiteheads in red robes greet Leon when he moves up the stairs. The first whitehead points at Leon and shouts, then runs back the way he came. He ends up standing in a corner facing the wall, like Mike at the end of ''Film/TheBlairWitchProject''.
* Sometimes the zealots chant, "Cerebros, cerebros, cerebros" (spanish for "Brains, brains, brains"), a shoutout to 1985's ''Film/TheReturnOfTheLivingDead''.
* Luis' manner of death, impaled in the chest by surprise, from behind, by an previously unseen enemy, is a shoutout to Bishop's (non-fatal) evisceration in ''Film/{{Aliens}}''. Foreshadowed when Luis had earlier quoted ''Aliens'' in the cabin scene: "It's game time."
* Several of the story elements are taken straight off ''[[Series/TwentyFour 24.]]''
** TheDragon is named Ramon Salazar, after TheDragon in season three.
** The other Dragon is [[CaptainErsatz Jack Krauser,]] a slight change from Jack Bauer.
** Both the game and season three are centered on bioweapons and Spanish terrorists.
** Ada is working with the BigBad and intends to double cross him much like Nina.
* The entire cabin scene is modeled off the central scenario in ''Film/NightOfTheLivingDead1968''.
* Dr. Salvador and the "Bella Sisters" reference ''Film/TheTexasChainsawMassacre1974'' with their equipment and head-gear:
** [[ChainsawGood Both sets of characters wield their chainsaws]] with [[OneHitKill iconic precision]].
** The faces of both sets of characters cannot be seen due to an eye-slotted potato bag for the former and head bandages for the latter, referencing Leatherface.
** Dr. Salvador actually looks like Jason Vorhees did in Film/FridayThe13thPart2 with the overalls and sack instead of his iconic hockey mask.
** When Leon and Ashley crash through the window to escape their first meeting with Lord Saddler, they way they leap (especially Ashley) is identical to how Sally jumps through the window during her final escape from the Leatherface family homestead.
** And finally, in the Kitchen of the final act's military base, Leon hears banging from the ''inside'' of a freezer, just like how Kurt hears Pam desperately banging for help from the inside of the icebox that Leatherface trapped her in... He finds a bag with someone (or more likely ''something'') writhing inside, but eerily enough we ''[[NothingIsScarier *never* find out just *what* is writhing inside it.]]''
* As pointed out by Jonathan Ferguson [[note]]Keeper of Firearms and Artillery of the Royal Armouries Museum in the UK, home to thousands of iconic weapons throughout history. [[/note]] [[https://youtu.be/juPxEuUOxfA?list=PLpg6WLs8kxGMgYb13XjPgOKbm5O-CDq7R in a Gamespot video]], the oversized laser sight on the Killer 7 handgun makes it look a lot like the ".45 long slide" that the T-800 uses in ''Film/TheTerminator''.
* The Colmillos are straight up the dog-Thing from Film/TheThing1982.
[[/folder]]

[[folder:Video Games]]
* Help the trapped dog early on and he'll come back to help Leon in the first El Gigante fight. The dog is none other than Hewie from ''VideoGame/HauntingGround''. Also, the situation and result are a reference to the ancient Roman fable ''Androcles and the Lion''.
* In Chapter Five of Separate Ways, the prompt for Ada's grappling hook changes to "[[Franchise/TheLegendOfZelda Hook Shot]]."
* One of the weapons is not only titled ''VideoGame/{{killer7}}'', but it also resembles KAEDE's gun from said game. Shinji Mikami both produced and helped Suda write ''killer7'', and it was one of the other games in the "Capcom 5" set of (what were supposed to be) Gamecube-exclusives. Additionally, the way Leon rests the handcannon on his shoulder with the barrel behind his neck is identical to how Dan Smith carries his gun in ''killer7''.
* After the above-mentioned laser hallway, there's what looks like a throne room with an elevator behind it. Sitting down on the throne makes Leon and the camera take a similar pose to [[VideoGame/CastlevaniaSymphonyOfTheNight Count Dracula.]]
* Right after Mike gets shot down, Saddler paraphrases [[VideoGame/MetalGearSolid Liquid Snake]] when he tells Leon "Don't tell me you've never swatted a bothersome fly."
* Also from the same game Leon when he gets his first clue about Ada he says "There is an intruder besides me" the same way Snake does when hearing about Grey Fox.
* In the the HD releases, the trophy/achievement for unlocking all of the alternate costumes is entitled "[[VideoGame/DevilMayCry The S Stands for Stylish!!]]" Also counts as a DevelopmentGag, since one of ''[=RE4=]'''s various iterations evolved into the original ''Devil May Cry''.
[[/folder]]


[[folder:Miscellaneous]]
* In the second area after reaching the Castle, Leon and Ashley are attacked by cannon fire. The first shot destroys a [[http://www.duke.edu/web/DRAGO/humor/gazebo.html Dread Gazebo]].
* Krauser's wearing a [[Music/{{Prince}} raspberry beret]].
* Instead of a goose that lays golden eggs, the game has chickens that sometimes lay golden eggs.
[[/folder]]