The series is the ancestor of all first person shooter nods to both films and other videogames.

As such, every ContinuityNod, MythologyGag, CaptainErsatz, "NoCelebritiesWereHarmed", {{Expy}}, and ShoutOut reference in any of these games go here.

!Duke Nukem and Duke Nukem II
* In the "Mercury Mines" level of ''Duke Nukem 1'', Dr. Proton issues a taunt via a monitor:[[note]]The Duke Nukem 1 engine is very similar to the Commander Keen: Invasion of the Vorticons engine, as evidenced by playing both for at least half an hour each, and probably explains why the credits for Duke Nukem 1 include Tom Hall.[[/note]]
--> ''"Why bother Duke? Not even VideoGame/CommanderKeen could survive the perils of my Mercury Mines!"''

!VideoGame/DukeNukem3D
* [=E1L1=], "Hollywood Holocaust":
** The level is based on ''Film/EscapeFromNewYork''.
** 867 5309 written on the wall in the cinema restroom. It's a reference to the song "867-5309/Jenny" by Tommy Tutone.
** A ''Duke Nukem II'' game in the arcade (the previous game in the series)
** A ''BallsOfSteel'' pinball machine in the arcade (Apogee would later release ''BallsOfSteel'' for Windows)
** The "innocent?" billboard at the beginning of the level is reportedly also referring to OJ Simpson.
* [=E1L2=], "Red Light District"
** On the [=TVs=] in the bar area of the strip club is OJ Simpson's white Bronco.
* [=E1L3=], "Death Row":
** A hanging monk from ''RiseOfTheTriad''.
** The "[[VideoGame/{{Doom}} doomed]]" space marine.
** The poster in one of the cells covering a tunnel to the outside is a reference to TheShawshankRedemption.
** Later on, the player encounters Hannibal Lecter standing in his prison cell. (N64 version only)
* [=E2L2=], "Incubator", has at least two occurrences of the number [[Film/THX1138 1138]].
* [=E2L3=], "Warp Factor", is one big ShoutOut to ''Franchise/StarTrek'', from the overall shape of the level, to the secret mockup of the TNG ''Enterprise'' bridge.
** After revealing two secrets, the player can visit the bridge of the Enterprise, NCC-1701D, as well as Picard's "Ready Room".
* [=E2L6=], "Tiberius Station", was named after [[Franchise/StarTrek James Tiberius Kirk]].
* [=E2L7=], "Lunar Reactor" contains a mutilated [[Franchise/StarWars Luke Skywalker]] hanging upside down in stormtrooper armor.
--> ''"Now this is a force to be reckoned with!"''
* [=E2L8=], "Dark Side", includes the monolith from ''2001: A Space Oddysey'' near the end.
* [=E3L1=], "Raw Meat", starts with Duke sprouting the infamous ChewBubblegum line. He can also sing ''"BOOOORN TO BE WIIIILD"'' in the karaoke.
* [=E3L4=], "L.A. Rumble", has a building that crumbles due to an earthquake looks exactly like the building where id Software's offices are in. While the building crumbles Duke will state "[[VideoGame/{{Quake}} I ain't afraid of no Quake!]]"
* [=E3L5=], "Movie Set" is a movie set where a film based on the previous episode is being filmed. The helicopter that crashes at the start hits a water tower (a possible shout-out to Warner Bros, there). The poster for the film shows up in a couple of later levels, too.
* [=E3L7=] is named "Fahrenheit", the music is called "233C" and a fire engine is numbered "451". All of these are references to Creator/RayBradbury's ''Fahrenheit 451''.
* [=E3L8=], "Hotel Hell", has a secret area, found by entering behind the pool's waterfall, where IndianaJones is speared.
--> ''"We meet again, Dr. Jones."''
* [=E3L11=], "Freeway", includes a flattened {{Terminator}} in a compactor. When you go inside for a look:
--> ''"Terminated!"''
** Near the end of the level, the player will face a police car on its side with the number 54. This is an homage to ''Car 54, Where Are You?''
** The blimp advertises for [[TheSimpsons Homer Simpson's]] beer.
** There's TV footage parodying the OJ Simpson car chase. It also shows up in several other levels, notably E1L2 and E3L1.
* [=E4L1=], "It's Impossible", is a big ShoutOut to ''MissionImpossible'', but also includes a corridor of opening doors, along the lines of the ''Series/GetSmart'' opening titles.
** There are also magazines featuring [[Film/JamesBond Moger Roore]] on the cover.
** There are also an umbrella and a hat hanging under the sign "Steed" in the level - an obvious reference to Series/TheAvengers
** And, of course, a sign of [[TheManFromUNCLE U.N.C.L.E.]]
* [=E4L2=], "Duke Burger", has [[BeavisAndButthead Butthead]] through the drive-thru speaker of the restaurant, admonishing the player to leave, because the place is 'like, closed'.
** The list of specials includes references to ''Film/PulpFiction'' - Big Kahuna Burgers are most prominent.
** Not to mention the brief appearance of [[Franchise/ScoobyDoo "Scrappy Due"]].
* [=E4L3=], "Shop-N-Bag", is based on a real chain of stores with the same name which closed down in the late 1990s.
** At one point, Duke comes across a badly mutilated corpse dangling from the ceiling. Said body is that of [[Film/EscapeFromLA Snake Plissken]]. If the player takes a closer look at it:
--> ''"Huh. Guess he didn't escape from L.A."''
* [=E4L5=], "Pigsty", contains several desk name-blocks which reference a number of characters in law enforcement from 'Film/DieHard'', ''JudgeDredd'' and ''DirtyHarry''.
** The car-crashing-into-police-station sequence is a reference to TheTerminator, complete with Duke saying "I'll be back".
* [=E4L6=], "Going Postal", includes a reference to TheSimpsons - "trab pu kcip", to be viewed through a mirror. It also contains the infamous composite sketch of the Unabomber.
* [=E4L8=], "Critical Mass", has a secret area which is a mock-up of [[TheSimpsons Homer Simpson's]] work area, including donuts on the console and a sign saying "Sector 7-G".
* [=E4L9=], "Derelict", is a tanker named ''Valdez 2''.
* [=E4L11=], "Area 51", has a few for ''Film/IndependenceDay''.
* Duke's "Groovy" and "Hail to the king, baby!" are references to ''Franchise/EvilDead''.
* When you approach a captured woman, she'll spout "Kill Me". It's a reference to ''Film/{{Aliens}}''.
* The Chaingun Cannon is a [[GunPorn Russian made Pribor-3B Nordenfelt gun]].
* The {{Playstation}} port (''Total Meltdown'') has a control scheme called "VideoGame/{{Doom}}ed", named such because it's based on the default control scheme of the Playstation ''Doom'' port.
** The same port also add a new episode which features a few levels spoofing popular Playstation games: "Nightmare Zone" is based on the first level of ''VideoGame/TombRaider'', "Trackside Tragedy" parodies ''VideoGame/{{Wipeout}}'' and "Gates Motel" pastiches ''VideoGame/ResidentEvil'' and horror movies.

!Duke Caribbean: Life's A Beach
* The recurring boat is titled Kobayashi Maru. Three guesses [[Film/StarTrekIITheWrathOfKhan where]] that comes from.
* The title theme for the expansion pack is based on the ''Series/HawaiiFiveO'' theme.
* The key cards are replaced by [[BlandNameProduct Vista]] credit cards.
* L1 has Duke singing a [[Music/TheBeachBoys Beach Boys]] song.
* L2 features a quote from Film/TheFifthElement.
* L5 has quotes from FantasyIsland.

!Duke It Out In D.C.
* L1, "Hell to the Chief", is based on the White House, of course.
* L2, "Memorial Service", is based on the Lincoln Memorial.
* L3, "Nuked Files", is based on the FBI Offices. The name is a riff on ''Series/TheXFiles''.
* L4, "Smithsonian Terror", is based on the Smithsonian Museum, down to the exhibits.
* L5, "Capitol Punishment", is based on the Capitol, yes it is.
* The secret level, L10, "Top Secret", was based in part on a user map named "Aztec".
* L7, "Dread October", is referencing ''Film/TheHuntForRedOctober''.

!Duke: Nuclear Winter
* L1 and L2 are essentially [=E1L2=] and [=E1L1=], respectively, done in reverse.
* L3, "Land of Forgotten Toys", features [[SuperMarioBros Mario]] playing VideoGame/MarioKart and a portion of [=E1L1=] from the original VideoGame/{{Doom}} as part of the level.

!Duke Nukem: Manhattan Project
* The ''Duke Nukem 1'' sprite appears as graffiti in some levels.
* The intro cutscene, after two Ratoids wreak havoc, has Duke saying this before shooting his first bullet:
--> ''"[[{{Scarface}} Say hello to my little friend]]."''
* In the first level, there's an outdoor to the "Rats" play, a reference to Broadway's "Cats".
* In the second level, if you pick up a public phone you'll hear a woman's voice saying something like this:
--> ''"[[Film/TheMatrix I know you're searching something Duke, and I know how you feel. Follow the White Rabbit.]]"''
** Later, you must avoid some cars crossing a street. After a couple of times:
--> ''"[[{{Frogger}} What am I, a frog?]]"''
* After taking a Berserk pack, Duke sprouts this:
--> ''"[[ComicBook/FantasticFour It's clobberin' time!]]"''
* Crossing with DevelopmentGag and WhatCouldHaveBeen in VideoGame/DukeNukem3D part, the Pig Cops can hit the player with their gun, something which the Pig Cops were meant to do in ''3D'', but couldn't.
* Another one-liner, after he destroys a pair of camerabots:
--> ''"[[BritneySpears Oops, I did it again!]]"''
* The [[GuideDangIt secret boss]] [[SphereOfDestruction Wozma]] seems to be a reference to [[VideoGame/FinalFantasyIX Ozma]].
* The plot of small animals mutating when coming into contact with spilled ooze, especially in a game called The Manhattan Project, is [[Franchise/TeenageMutantNinjaTurtles strangely familiar.]]

!VideoGame/DukeNukemForever
* In the first room, there are names of all ex-3DRealm employees on a plaque above the football uniforms, including Broussard's.
* One of the things Duke sees while flipping TV Channels is The Holsom Twins' music video, from the album ''FullHouse''...
* The name of the late night show host is actually a combination of the names of various Real-Life late night show hosts.
--> '''Johnny''' Carson, Conan '''O'''' Brien, Jay '''Leno''' and David Letter'''man'''
* At the late night show ''Damn, It's Late'', if Duke speaks into the mic, he boasts, "[[Film/EscapeFromNewYork I am the Duke! I am A-number one!]]" It's not the last time he says it.
* The computers in the Duke Cave has a damn accurate boot bios screen, resembling those of an Award BIOS boot PC.
* When shrunken in the casino, after killing some rats, Duke will comment, "Talk about [[Film/ThePrincessBride Rodents of Unusual Size]]!"
* Killing some aliens, Duke will sometimes say, "[[Film/{{Commando}} Remember when I said I'd kill you last? I lied.]]"
** Or "[[Film/ThreeHundred Tonight, you dine in hell!]]"
** Or "[[ShadowWarrior It's all in]] [[Film/BigTroubleInLittleChina the reflexes]]."
** Or "[[Franchise/EvilDead Good, bad, I'm the guy with the gun.]]"
* When the first Battlelord appears, Duke yells, "[[Film/{{Predator}} You are one, ugly motherfucker!]]"
* At one point, Duke [[http://cache.gawker.com/assets/images/kotaku/2011/02/dukehalo.jpg finds]] a [[VideoGame/{{Halo}} certain set of green armor]], and snarks, "Power armor is for pussies!" Overlaps with MythologyGag, since Duke found a dead VideoGame/{{DOOM}} marine in ''VideoGame/DukeNukem3D'', which he commented, "[[IncrediblyLamePun That's one DOOMED marine!]]"
** Also overlaps with TakeThat, aimed at [[http://godmodeonline.com/d/20070924.html God Mode]], as the Marine says "Duke, we got your green power armor!" just before Duke snarks at him.
* Duke comes across an EDF soldier who knew Duke's retirement "bullshit was just bullshit". He then goes on in a mocking voice about how he just [[VideoGame/GearsofWar helped one of his friends find his wife]] and calls his friend a pussy.
* The game's RegeneratingHealth bar being an Ego bar might be a reference to the Ego system on ''VideoGame/DukeNukemManhattanProject'', where Duke would get ego by shooting things, freeing women and, of course getting ego boxes.
* The first level of the game is a boss fight against [[spoiler: the Cycloid Emperor, last boss of the third episode of VideoGame/DukeNukem3D]], taking place in [[spoiler: the very same stadium...sort of.]]
* The "Balls Of Steel" [[LimitedSpecialCollectorsUltimateEdition edition]] and the achievement of the same name might be references to [[VideoGame/BallsOfSteel an old 3D Realms pinball]], and a ShoutOut to a line that quickly became memetic due to a harassment video where Duke's voice lines from ''VideoGame/DukeNukem3D'' were played to infuriate a Ventrilo server admin.
** "I'ma kill you old style!" is a reference to said harassment.
* Duke's autobiography, "Why I'm So Great," was first mentioned in Duke Nukem II.
* In the First Access Demo, when exploring some mining tunnels, as Duke breaks through wooden barricades, he declares his need for a [[VideoGame/{{Half-Life}} crowbar]] in a situation like that.
* The Railgun in the First Access Demo looks and sounds suspiciously like the VideoGame/QuakeIIIArena railgun.
** The Railgun in the released game, when zoomed in, uses the same scope overlay as ''[[VideoGame/ModernWarfare Call of Duty 4]]'''s sniper rifles.
* The four achievements for completing the campaign in Easy, Normal, Hard and Insane are called [[VideoGame/DukeNukem3D Piece of Cake, Let's Rock, Come Get Some and Damn, I'm Good]].
* Another achievement, for hitting 15 aliens with melee attacks while in BerserkMode is called [[Comicbook/TheIncredibleHulk Duke Angry, Duke Smash!]]
* The [[http://www.youtube.com/watch?v=GVwdXjnpFOM&t=10m19s four-digit code]] that Duke enters into the Super Turret is [[Film/THX1138 1138]].
* Duke's monster truck is called [[VideoGame/DukeNukem3D Duke's Mighty Foot.]]
* The twins that appear in the game are called the Holsom twins, alluding to the Olsen Twins. This is not the only reference they are to, however, since their multiplayer reward description is "2 Girls, 1 Duke", referencing infamous ShockSite 2girls1cup.
* Several in the Strip Club level:
** There's a sign saying [[Film/FromDuskTillDawn "Open Dusk Till dawn".]]
** A cash terminal showing the message [[Literature/AmericanPsycho "Feed me a stray cat".]]
** A [[Film/{{Inception}} spintop which doesn't stop spinning.]] [[spoiler: This is a clue that the level is AllJustADream.]]
** The answering machine next to the top mentioned above will replay the message [[WesternAnimation/AquaTeenHungerForce "Tonight... you!"]]
** The toilet has [[Film/TheShining "REDRUM"]] written on the wall opposite the mirror.
** In the bathroom stall there's some graffiti that says, "[[Film/TheyLive THEY LIVE WE SLEEP]]".
* In a specific part of the chapter "The Hive", a decapitated soldier and a very familiar-looking helmet can be found, which Duke comments on by saying "That is one Franchise/DeadSpace marine!"
* You get an achievement for sticking enemy with a laser tripmine called [[ShadowWarrior "Sticky bomb like you!"]]
* Early in the "Vegas in Ruins" chapter, Duke gets assigned to accompany a private named Jenkins. [[LeeroyJenkins He immediately runs right ahead of you into the action, disregarding any tactics]], and as a result, he dies quickly. [[VideoGame/WorldOfWarcraft Sounds familiar]]?
** Duke moans, "Damnit, Leeroy!" as well.
* All of the cash registers have the value of [[TheSimpsons $847.63]]
* [[Film/StarshipTroopers "I'm from Las Vegas and I say kill 'em all!"]]
* In the freezer room with all the pipes, Duke says "I hate [[Creator/ValveSoftware valve]] puzzles."
** Perhaps doubling as a shout-out to [[VideoGame/Left4Dead Francis]].
* When Duke stomps on a tiny Pigcop in Duke Burger, one of his lines is "Better than [[SaintsRow Freckle Bitch's!]]"
* "Duke Burger" itself may be a StealthPun on "Advertising/TheBurgerKing" (because Duke is King).
* In one part of the [[spoiler: Hoover Dam]], Duke ascends a long spiral stairway while [[VideoGame/DonkeyKong dodging incoming barrels, remarking "Where's a hammer when you need one?]] He finds a Pigcop at the top, but remarks he was [[VideoGame/DonkeyKong expecting a monkey.]]
* [[spoiler: The ending is a parody of Jackson's death and the ending of ''Call of Duty 4: VideoGame/ModernWarfare'', to which Duke replies "What kind of shit ending is that?"]]
* Sometimes, if Duke steps on a rat, he'll say, "See you later, [[MickeyMouse Mickey]]!"
* The girl in the Duke Burger kitchen may wonder if "there'll be another season of [[{{Firefly}} Lightning Bug]]."
* Behind the set of the "Damn It's Late Show" there's a stage hand getting berated by an angry actor for walking across the stage during filming, a parody of Creator/ChristianBale's infamous rant on the set of ''{{Terminator}} Salvation''. Duke can even punch him out:
---> ''Stage Hand: "Thanks Duke. [[TakeThat That guy was a douche.]]"''
* After killing the Triple Boob Monster, nearby is some evidence ''SamAndMaxFreelancePolice'' were there.
** On seeing the said monster, Duke quips, "Baby, you make me wish I had three guns", a reference to the original ''Film/TotalRecall1990''.
* Upon cracking open a supply crate, Duke might say [[Film/RoboCop1987 "I'd buy this for a dollar", or "I like it!"]]
* One of the ambient music files is named [[Series/StargateSG1 WormHole_Xtreme]].
* The aerial assault level prior to getting the Mighty Foot features "Music/RideOfTheValkyries" as the soundtrack, slowly creeping from orchestra into heavy metal. Neat!
* If Duke gibs another player online, he will sometimes boast "[[Film/PulpFiction I'm a mushroom-cloud laying motherfucker!]]"
* Occasionally after getting drunk, Duke will shout "You're my boy, Blue!" which was one of Will Ferrel's lines from OldSchool.
* While persuading Duke to run a few errands, the stripper promises him a lapdance... and [[TheCakeIsALie cake]].
** Speaking of VideoGame/{{Portal}}, there's a secret room in the dam where you can find a [[CompanionCube barrel with hearts on it]].
* In one level, "[[ShadowWarrior Lo Wang]] was here" is scrawled on a wall.
* When shrunk during Duke Burger stage, during navigating a room with electrified floor, music suspiciously reminiscent of MouseHunt will play.
* The first DLC includes quite a bit of snapping towards other multiplayer games and websites, with new maps called "[[VideoGame/CallOfDuty Call of Duke]]" and "[[VideoGame/TeamFortress2 2forts]][[ShockSite 1bridge]]".
* Octobrains, underwater. [[DoesThisRemindYouOfAnything Does this reminds you of]] [[Franchise/SuperMarioBros anything]]?
* [[TeamAmericaWorldPolice America, Fuck yeah!]]
* The computer in the Duke Cave, when the power goes down, talks suspiciously like [[SystemShock SHODAN]].
* "[[Film/AirForceOne Get off]] [[Film/GranTorino my dam!]]"
* The music played at the Duke Dome, with the air raid siren, is lifted from VideoGame/{{Fallout}}.
* Sometimes, when Duke kills a Pig Cop, he'll quip, "[[GIJoe Porkchop]] [[AscendedMeme sandwiches]]."
* The singleplayer [=DLC=] campaign is titled ''The Series/DoctorWho [[Film/JamesBond Cloned Me]]''.
* In the first level of that [=DLC=], Duke [[VideoGame/CallOfDutyBlackOps wakes up on a chair in a video room while a voice talks from a speaker]].
* The first enemy he faces is a robotic endoskeleton called a [[{{Terminator}} Dukeinator]].
* Doctor Proton looks like a [[Franchise/StarTrek Borg]] from the waist up.
* To insult Doctor Proton, Duke calls him a "[[{{Twilight}} spidermonkey]]".
* When Doctor Proton recharges his energy, he exclaims: "[[StarWars Power! Unlimited power!]]
* The donkey in the safety video in Area 51 and outside the Burning Bush refers to the 1999 iteration of DNF, where Duke would've met an old miner named Gus, who would've lent him his donkey to reach the bottom of the Grand Canyon.
* The Impregnader is a weapon that works exactly like the [[VideoGame/{{Unreal}} GES BioRifle]].
* In the climax of the [=DLC=], Duke uses a [[VideoGame/CallOfDutyBlackOps teleporter in Area 51 to reach a base on the moon]].

!Other Duke games
* In one level of Duke Nukem: Time to Kill, Duke can come across the Delorian from ''Film/BackToTheFuture''.
** In another, he finds the corpse of [[Franchise/TombRaider Lara Croft]].
* The BadFuture of ''Zero Hour'', has the Statue of Liberty half-submerged in nukage, a reference to PlanetOfTheApes.