* Several comics have AltText that bring up Meta Knight's GameBreaker status in the ''VideoGame/SuperSmashBrosBrawl'' competitive community.
* [[http://brawlinthefamily.keenspot.com/comic/gooeykablooie/ #50]] is done nicely InTheStyleOf [[ComicStrip/CalvinAndHobbes Bill Watterson]], with Kirby as Calvin and Dedede as Hobbes.
* [[http://brawlinthefamily.keenspot.com/2008/07/16/shave/ One memorable strip]] actually had a comment saying that Matthew's nerdiness had reached new heights (even though [[Franchise/StreetFighter the reference]] isn't that hard to grasp).
* [[http://brawlinthefamily.keenspot.com/comic/104-cardboardbox/ #104]] is a strip about Snake goofing around in his cardboard box. The author's note?
-->''Next up, [[ComicStrip/CalvinAndHobbes scientific progress goes “boink”]] as Snake uses the box to clone himself!'' [[note]]Referencing two different story arcs from ''C&H''.[[/note]]
* [[http://brawlinthefamily.keenspot.com/comic/115-htksc2/ How the King Stole Christmas (Part 2)]] has King Dedede do an impression of [[VideoGame/TheLegendOfZeldaCDiGames CD-i Link's]] infamous laugh when the lyrics say "the only game YOU deserve is on the... Philips CD-i!"
* In [[http://brawlinthefamily.keenspot.com/comic/125-babysitting/ 125]], Baby Mario's prattling ends in the second panel with "[[WesternAnimation/SuperMarioWorld now I know how a meatb...]]"
** And from the same episode, in [[http://brawlinthefamily.keenspot.com/comic/mkc5/ 205]], Luigi strikes a [[MemeticMutation rather familiar pose]] while mentioning Yoshis who call him "mama".
** Also in the above strip, a middle-aged witch girl appears, but people likely won't know who she is until she shouts...
--->'''Ashley:''' [[VideoGame/WarioWare PANTELONES GIGANTICUS!]] [-[[RunningGag ...oh no, not again...]]-]
* [[http://brawlinthefamily.keenspot.com/comic/158-captainfalconcarpoolstowork/ Captain Falcon evidently commutes with]] ''WesternAnimation/{{Futurama}}'''s Hermes Conrad, as well as Dwight from ''Series/TheOfficeUS''. In TheRant, Matt explains that he put "hints" as to who they are supposed to be in each of their cars (Hermes has an air freshener that looks like the Planet Express ship, and Dwight has a brand on his steering wheel that looks like a beet and has the Schrute Farms initials).
* Pichu's evil expression [[http://brawlinthefamily.keenspot.com/2009/09/04/186-pichu/ here]] is a direct copy of the [[WesternAnimation/HowTheGrinchStoleChristmas Grinch's]]. The AltText expands by providing the commentary during that scene in the special.
* [[http://brawlinthefamily.keenspot.com/comic/smallbreak/ #190]]: "Where's Waluigi" is a parody of ''Literature/WheresWally''. Wally himself is hidden in the comic: [[spoiler:he's hiding behind Bowser Jr.'s painting.]]
** [[VideoGame/{{KidIcarus}} Eggplant Wizard]] and [[VideoGame/PunchOut King Hippo]] are standing next to each other, referencing their role as a BumblingHenchmenDuo in ''WesternAnimation/CaptainNTheGameMaster''.
* The [[http://brawlinthefamily.keenspot.com/comic/245-sitg5/ conclusion of the "Snake in the Grass" arc]] has Solid Snake assuming the same position as a certain unconscious, naked guard from the first ''VideoGame/MetalGearSolid''.
* [[VideoGame/{{Persona4}} Teddie]] makes an appearance in strip [[http://brawlinthefamily.keenspot.com/comic/249-nasty/ 249]].
* [[http://brawlinthefamily.keenspot.com/comic/250-cartoons/ #250]] references [[WesternAnimation/TheSimpsons four]] [[WesternAnimation/KingOfTheHill different]] [[WesternAnimation/SouthPark comedic]] [[WesternAnimation/{{Futurama}} cartoons]], plus the [[Anime/KirbyRightBackAtYa Kirby anime]].
** This has been done before, in [[http://brawlinthefamily.keenspot.com/comic/150-comicstrip/ #150]], referencing [[ComicStrip/{{Peanuts}} five]] [[ComicStrip/TheFarSide different]] [[ComicStrip/ForBetterOrForWorse comedic]] [[ComicStrip/FoxTrot newspaper]] [[ComicStrip/{{Garfield}} strips]].
* [[http://brawlinthefamily.keenspot.com/comic/300-asimplerequest/ #300]] has Ganondorf [[FlippingTheTable kicking over a chessboard]] in a very [[WesternAnimation/BeautyAndTheBeast Gaston-like]] context and fashion.
* The alt text for [[http://brawlinthefamily.keenspot.com/comic/310-thecasanova/ 310 - The Casanova]] pulls a RussianReversal of the old [[Franchise/{{Pokemon}} Mudkip]] [[MemeticMutation meme]], fitting with the comic:
--> So I heard Mudkip likes you?
* In [[http://brawlinthefamily.keenspot.com/comic/322-cocoonacademy10/ Part 10]] of "Cocoon Academy", [[spoiler:when Pinky wakes up in the nurse's office after absorbing some of Dark Matter, the first thing he says is "[[Film/Batman1989 Mirror... MIRROR!!!]]"]]
* The creator's comments for [[http://brawlinthefamily.keenspot.com/comic/235-pokemonpedometer/ strip 235]] say [[WebAnimation/HomestarRunner "LENS FLAAAAARE"]]
* The AltText for [[http://brawlinthefamily.keenspot.com/comic/257-bananahoarde/ this]] strip discusses what DK's Giant Punch would be like if it were a ''TabletopGame/MagicTheGathering'' card.
* The sound made when Peach falls into the grass outside Bowser's Castle in "[[http://brawlinthefamily.keenspot.com/comic/260-thecaptiveprincess/ The Captive Princess]]" is "POOMP", which is the same produced when you land a huge jump in ''VideoGame/MarioKart64''.
** Similarly, the Gooey Bomb goes off with a "[[VideoGame/SuperMarioBros2 BOMB]]" [[spoiler:when Meta Knight accidentally stabs it.]]
* For whatever reason, several of the "Waluigi in the Family" strips are named for levels in ''VideoGame/TeenageMutantNinjaTurtlesTurtlesInTime''.
* [[VideoGame/{{Okami}} Amaterasu]] had a quick cameo in an alternate ending of [[http://brawlinthefamily.keenspot.com/comic/364-sunssong3/ Sun's Song, Part 3]], fixing the mess Link had made.
* The strip [[http://brawlinthefamily.keenspot.com/comic/382-tired/ "Tired"]] has a [[ExactlyWhatItSaysOnTheTin tired]] Mario [[WesternAnimation/TheSimpsons hallucinating about going to his bed, among various clouds, with the moon smiling at him, all while driving back home.]][[note]] For those who didn't get it, an early episode of ''The Simpsons'' did it when Homer was driving back home from a second job at the Kwik-e-Mart because he had to afford a pony for Lisa.[[/note]]
* The author's note for [[http://brawlinthefamily.keenspot.com/comic/425-shyguyparty/ this comic]] starts off with a reference to ''WesternAnimation/PhineasAndFerb''.
* In [[http://brawlinthefamily.keenspot.com/comic/495-comicreviewe32013/ this strip]] [[VideoGame/KidIcarus Pit]] and VideoGame/{{Mega Man|Classic}} recall their time in the ''WesternAnimation/CaptainNTheGameMaster'' cartoon... although Mega Man [[OldShame wishes he didn't]].
** In the same strip, Jigglypuff (now a Fairy-type) is seen with [[WesternAnimation/TheFairlyOddParents a wand, a floaty-crown-thing, and a copy of Da Rules.]]
* In the [[http://brawlinthefamily.keenspot.com/comic/500-prodigal-robot/ 500th comic milestone video]], Mega Man, homeless and looking for work, periodically alters his message on the board behind him to say, at various points:
** "[[WesternAnimation/WreckItRalph Game unplugged, please help!]]"
** "[[VideoGame/TatsunokoVsCapcom C'mon,]] [[Characters/MegaManClassic Roll]] [[VideoGame/TatsunokoVsCapcom got to hang out with]] [[Anime/ScienceNinjaTeamGatchaman Jun the Swan]]"
** "[[VideoGame/MarvelVsCapcom3 and]] [[VideoGame/MegaManX Zero]] [[VideoGame/MarvelVsCapcom3 is partying with]] ComicBook/SpiderMan"
** Speaking of that video, it ends with a cartoon version of the opening of Mega Man's trailer of ''Super Smash Bros. 4''.
** Speaking of Roll and Zero, Mega Man bumps into Ryu, hoping to join him [[VideoGame/StreetFighterXTekken in his next game]]. Ryu awkwardly reveals that they already got ''a different'' Mega Man, one from the American Box Art.
*** HilariousInHindsight, given how Ryu was eventually added as DLC.
** In the ''VideoGame/MegaMan3'' party scene, his allies [[VideoGame/{{KidIcarus}} Pit]] and [[VideoGame/{{Castlevania}} Simon Belmont]] from ''WesternAnimation/CaptainNTheGameMaster'' can be seen, plus [[VideoGame/{{Metroid}} Samus]] from the comic book adaptation who replaced the third party characters for copyright reasons.
* [[http://brawlinthefamily.keenspot.com/comic/550-plumbers-best-friend/ His name is Yoshi]], [[WesternAnimation/{{Up}} and he loves you.]]
* [[http://brawlinthefamily.keenspot.com/comic/563-newability/ #563]] has Kirby turn into [[WesternAnimation/{{Archer}} Sterling Archer]] upon consuming an archer. The Alt Text states that that the Bell ability [[WesternAnimation/BeautyAndTheBeast lets him converse with candlesticks, clocks and teapots]].
* [[http://brawlinthefamily.keenspot.com/comic/574mariomaker/ #574]] ends with a clever reference to the ending of [[spoiler:''WesternAnimation/DuckAmuck'']].
--> [[spoiler:'''Bowser:''' Ain't I a stinker?]]
** And the AltText pun:
---> [[spoiler:[[WesternAnimation/LooneyTunes What's up, Doc]][[VideoGame/DrMario (tor Mario)?]]]]
----