* Bowling is apparently a huge deal in ''Manhua/BowlingKing''. No, seriously. Professional bowlers are all either incredibly badass or {{Bishonen}} prettyboys. Oh, and then there's how main character Shautieh Ley's ultimate goal seems to involve taking over the world with bowling somehow; while this isn't explicitly stated, chapter opening pages tend to feature things like a RushmoreRefacement where ''all'' of the faces are Shautieh (and similar ones with the Sphinx, etc.) and Shautieh disrupting other sports events.
* Creator/DCComics had a [[TheGoldenAgeOfComicBooks Golden Age]] hero called Manhunter, then bought another Golden Age hero called Manhunter. In a {{Retcon}}, the two men had an argument over who got to keep the name, and they settled it by having one of them ''go to [[AlternateUniverse another universe]]''. This a LampshadeHanging on how writers in comics loved to remove problems by having them turn out to take place in alternate universes.
* ''ComicStrip/KnightsOfTheDinnerTable'' has roleplaying games as serious business.
** "You don't understand man." "He TOUCHED my dice!"[[note]]Ask any hardcore gamer in Real Life. Touching someone else's dice/mini/whatever without permission can be considered a breach of etiquette, and with some players, is indeed Serious Business.[[/note]]
* In one ''ComicStrip/CalvinAndHobbes'' strip, Calvin throws an enormous hissy fit after losing a game of checkers to Hobbes. When Hobbes points out that it's just a game, Calvin cheerfully replies: "I know! You should see how I act when I lose in real life!"
** Chewing gum is Serious Business in the ''ComicStrip/CalvinAndHobbes'' universe. Calvin is an enthusiastic reader of a magazine called "Chewing" which is dedicated to it, and informs an incredulous Hobbes that as many as twelve such publications exist.
** So is a SnowballFight.
** And he treats his snowman creations like modern art. Though he certainly puts more thought into them than most kids. This is [[CloudCuckooLander Calvin.]] ''Everything'' comes to life, and most of it [[EverythingTryingToKillYou tries to kill him.]]
* ''Comicbook/{{Bookhunter}}'' takes place in an alternate-universe 1970s where books and libraries are so important that a branch of the police is devoted to investigating library-related crime.
-->'''Agent Bay:''' In many respects the American Library has become the most basic First Amendment institution. We are guards, yet we guard no less than the sum of human knowledge. We are the library police.
* ''ComicStrip/TheFarSide'' once had a ShowdownAtHighNoon having ended in defeat for the older cowboy, treating it with all the gravity you'd expect... except it was at ping-pong.
-->'''Older gunslinger''': Well, you won. Now every player in the world will come after you, looking to make a name for himself... Welcome to Hell, kid.
* [[http://dilbert.com/dyn/str_strip/000000000/00000000/0000000/000000/00000/7000/100/7165/7165.strip.gif This]] ''{{ComicStrip/Dilbert}}'' strip illustrates how to apply the principles of SeriousBusiness in the workplace.
** This comic was based on one of Scott Adams' coworkers, who actually said "I will fight you to the end of the earth!" To him, it was serious business.
* In ''WelcomeToTranquility'' Captain Cobra and Mongoose Man are not just enemies, but "enemies to the DEATH." Unfortunately, their advancing years are actually bringing them pretty close to that goal line and they have both retired from super-activities, heroic and villainous alike. So, what is left for them to be enemies over? Why, the apple tree that looms over both their properties, and who has proper ownership over the apples that fall down on either side of their fence. Just ask Sheriff Lindo, apples are ''serious business''.
* Beef is Serious Business in the CrapsackWorld of ''Comicbook/GiveMeLiberty''. Fast-food restaurants wage wars for farmland, people commit suicide for hamburgers, and there's even a 94th Amendment outlawing red meat.
* [[http://comics.com/pearls_before_swine/2010-01-17/ Board games]] are apparently serious business to Rat in ''Comicstrip/PearlsBeforeSwine''.
* The people of a Hannoverian village who want to celebrate the birthday of their ex-king (Hannover was conquered by Prussia in 1866; some people nursed a grudge because of this, and pro-Prussian Creator/WilhelmBusch wrote this story as a TakeThat).
* One ''Cthulhu Tales'' comic had an unnamed "Maine Cheetahs" baseball fan ([[BlandNameProduct according to Google, no such team exists]]) for whom baseball was ''such'' serious business, he went so far as to ''invoke Cthulhu'' in order to win them their first World Series in seventy years. [[EldritchAbomination It doesn't appear to end well for anyone concerned]].
* In the German comic ''ComicBook/{{Werner}}'': Brewing beer, tuning bikes %% This entry was added automatically by FELH2. In case the wording doesn't make sense, rewrite it as you like, remove this comment and tell this troper.
* The "Sorry Cake" in Issue #3 of ''ComicBook/MyLittlePonyFriendshipIsMagicIDW'':
-->'''Pinkie Pie:''' Luckily, I always travel with an "I'm sorry" cake! I also have "I am sorry" goodie bags!\\
'''Twilight Sparkle:''' Uh, Pinkie, I don't think we have time for cake... we are only an hour away from the Changeling kingdom...\\
'''Pinkie Pie:''' '''EAT... THE... CAKE.'''
* When WonderWoman was stuck working at [[BurgerFool Taco Whiz]], she took the job very seriously. Then again, she takes everything seriously, except [[{{Batman}} Batman's]] brooding.