BBC comedy show that has been running on-and-off since 1994, named for the {{Room 101}} from the novel ''Literature/NineteenEightyFour''. When hosted by Nick Hancock (1994-97) and Paul Merton (1999-2007), it was a chat show where that week's featured guest nominated some of their pet hates and argued why they should be consigned to Room 101; the host then had to decide whether or not they had made a persuasive enough argument.

In 2012, a revamped edition hosted by Frank Skinner began, with the programme now taking the format of a PanelGame as three different guests argued across a series of categories to try and get their chosen items into Room 101.

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!!This show contains examples of:
* AccentuateTheNegative: The whole point of the show. Much of the comedy is found out of people attempting to put in rather tiny things, such as rooks.
* BerserkButton: Often one particular little thing is what causes the guest's annoyance with their nomination. For example StephenFry's dislike of 'New Agers' was mostly to do with the misuse of the word "energy".
* {{Catchphrase}}: In Paul Merton's run he would introduce each episode with "Imagine you could get rid of some of your worst nightmares--what would they be? My guest tonight is here to convince me to banish some of the items on his/her list to Room 101".
* ColbertBump / ItsPopularNowItSucks: InUniverse, Johnny Vegas reluctantly tells Paul the name of the chatroom he's addicted to: "''Beauty's Castle''... everyone will start visiting it now it'll be ruined!"
* EvenEvilHasStandards: The room once 'vomited' out Piers Morgan, on the grounds he was [[TakeThat 'too toxic']].
* IWasQuiteAFashionVictim: One of BillBailey's reasons for hating the 1980s.
* LighterAndSofter: Paul Merton was far less strict about letting things into Room 101 than Nick Hancock, and the show was more of an excuse for amusing anecdotes.
* LogicBomb: Stephen Fry's last choice to go into Room 101 was ''Room 101'' itself. Paul Merton eventually agreed that it should go in, and pulled the lever -- causing an IdiosyncraticWipe to black, and the immediate end of the episode.
* [[NoIndoorVoice NOINDOORVOICE]]: Excessively loud people have been nominated by several guests.
* OldShame: InUniverse. Frequently guests will be reminded of their own past faux-pas, such as Creator/RickyGervais's time as the singer in a 1980s new romantic band (he looked genuinely embarrassed).
* {{Retool}}: The Hancock/Merton-fronted original run was on Creator/{{BBC}}2 and took the form of a light-hearted chat show. The Frank Skinner series has moved to [=BBC1=] and has turned it into a more straightforward PanelGame.
* RightBehindMe: After Kirsty Young had used Creator/BrianBlessed as an example of people who are too loud, Paul introduced him from backstage. He also ''pretended'' to do this to Dara Briain with Gillian [=McKeith=], eliciting an amazing OhCrap face.
-->''[after saying goodbye to Brian Blessed]''\\
'''Paul:''' You did say he was a nice man before he came on.\\
'''Kirsty Young:''' I did -- thank ''God'' I said that.
* RunningGag: For the final Merton-hosted episode (which proved to be the final episode of the run until the {{Retool}}ed series), the guest was Ian Hislop, Merton's opposing team captain on ''Series/HaveIGotNewsForYou'' and the only guest to appear twice in the original run. He deliberately chose items he knew Merton liked, such as TheBeatles and Creator/CharlieChaplin, all of which were refused, culminating in the final choice being the show itself.
* SelfDeprecation: Creator/JonathanRoss nominated his own dress sense.
* SeriousBusiness: Nick Hancock (a former teacher) claimed all teachers regard [[SpotOfTea biscuits]] as this.
* SnipeHunt: When Rich Hall learned that NASA had calculated the weight of the Earth, his first thought was that it was a joke project assigned to a particularly incompetent scientist to keep him out of everyone else's way.
* SwappedRoles: In the first episode hosted by Paul Merton, Nick Hancock was the guest.
-->'''Paul:''' Are you familiar with how ''Room 101'' works?
* TakeThat: The point of some of the nominations.
* TastesLikeDiabetes: InUniverse. One of Nick Hancock's items was '(annoyingly) happy people', and he gave the example of a bus driver he'd known:
--> "Look, there! A tree! ''Growing''! '''Well done!'''" (thumbs up) "There's a bloke, getting his shopping--''good for him!''"
* ThatCameOutWrong: Kirsty Young was [[BrokenPedestal disappointed]] meeting Jon BonJovi: "He actually made me gag..." (pause) Paul: "So you did get on well then?"