* Pick a Creator/BioWare game - any [=BioWare=] game - and there's guaranteed to be a reference somewhere to [[VideoGame/BaldursGate "Go for the Eyes, Boo! Go for the Eyes!"]]
* ''VideoGame/{{Sonny}}'' has one about Felicity knifing Veradux in the face. The first time they meet, he almost lines up a shot and she throws a knife at him. The second time they meet, she throws a knife at him as she [[VillainExitStageLeft escapes]], prompting a shout of "ow! My face! Again!". When she shows up later and joins your party, [[DeadpanSnarker Sonny]] comments "quick, cover your face.". She also has an attack in-game that inflicts a debuff described as the victim having a knife in its face.
* ''VideoGame/{{Sam And Max|Freelance Police}}'': The second ever example of Sam letting Max answer the phone (Look in the ''Sam and Max'' entry in Western Animation for the other) occurs in the last episode of Telltale's second episodic season. [[spoiler:Hell freezes over, at which point the phone starts ringing and Sam just stands by and lets Max answer the phone. Max also won the Nobel Peace Prize, and Sybil lets him be the official at her wedding.]]
** During the Telltale games episodes, you can ask Bosco for various ridiculous items, which he almost invariably doesn't have, including "hats in the shape of a cow udder", "Self respect" (''"Ha, got you!" "No, I understood the question, all too well."''), "Vegetables in the shapes of naturalists" (Which is a shoutout to the first game, "Sam and Max hit the road") "Ketchup" (which he ''does'' have, but it takes him a second to realize he was asked about an actual thing), and "Weapons of Mass Destruction" (to which his answer was "Who's asking?"). In the last episode of Season 1, Sam asks for items which would have made every previous episode trivial (except the second, where the item either would have been useless or wouldn't have existed yet). He has ''all of them'', and you later find them right behind the lottery tickets.
*** In season 2, he's not running a store any more, but you can still torment him by asking him, even when [[spoiler:''he's naked in hell.'']] In the first episode, Sam asks for "passive aggressive payback disguised as innocuous customer inquiry?"
* In ''VideoGame/TalesOfTheAbyss'', every time the party needs to recap anything for an NPC, Jade makes Guy explain. There's no obvious reason why Guy should get stuck with the task. (Mercifully, the actual explanation occurs during a FadeToBlack.)
* Whenever the party gets involved in something bad in ''VideoGame/TalesOfVesperia'', expect Yuri to remark that he must be cursed.
** "The sign of Victory!"
* ''VideoGame/TalesOfSymphonia'' has a few: Raine's cooking being terrible (carrying on from a gag that started with PHantasa's Arche), her fear of water, Colette apologising at every little thing, Lloyd's hatred of Dwarven Vow #7 ("Justice and love will always win!"), Zelos [[HandsomeLech flirting with every girl he meets]], Sheena (and Colette's) clumsiness, Raine's love of archaeology, Lloyd's "Give me your name and I'll give you mine" line he uses to anyone who asks him who he is (lampshaded at one point when Genis asks why he didn't say it and Lloyd responds "It's not worth it"), Genis being smart (almost to the point of InsufferableGenius) and Lloyd being dumb, etc.
** A small gag that occasionally occurs in the Z-button skits involving Zelos and Sheena, after the former says something perverted and/or insulting towards the latter:
-->'''Sheena:''' You better shut up or I'll smack you!
-->'''Zelos:''' Don't say it ''after'' you've smacked me!
* A recurring joke in ''VideoGame/TalesOfGraces'' is the messed-up "We are... awesome!" victory skit. Variants include Pascal hogging the screen, Hubert's glasses almost getting stepped on, and even Asbel lamenting that his team is unable to coordinate.
** Asbel's desk. It starts off messy and stays that way. Going back to it has him comment how he needs to clean it. Even after 7 years and 6 months... it's still messy.
--> '''Asbel:''' (thinking)"One of these days I'll clean this desk up."
* The ''Franchise/TalesSeries'' also has some jokes running between games. Observe the following:
** This one starts as a victory quote in ''VideoGame/TalesOfSymphonia''...
--> '''Colette:''' Our weapons are - love!
--> '''Genis:''' Justice! And?
--> '''Kratos:''' [[TheComicallySerious Ugh...hope.]]
** ...then gets appropriately revamped for the DarkerAndEdgier ''VideoGame/TalesOfTheAbyss:''
--> '''Luke:''' Our weapons are status-!
--> '''Jade:''' [[MagnificentBastard Scheming!]]
--> '''Anise:''' Playing ''dirty''
** ...and then ''VideoGame/TalesOfVesperia'' knocks it out of the park:
--> '''Estelle:''' Our weapons are love!
--> '''Yuri:''' [[VigilanteMan Justice!]]
--> '''[[DirtyOldMan Raven]]:''' SEXUALITEEEEEHHHAH!
** On a similar note, take this ridiculous winner, already funny in ''VideoGame/TalesOfTheAbyss''...
--> '''Luke:''' You're weak!
--> '''Guy:''' You're a hack!
--> '''Jade:''' [[DeadpanSnarker You're whack.]]
** ...and then mix it up with a dash of {{Cloudcuckoolander}} and we get this madness in ''VideoGame/TalesOfVesperia:''
--> '''Yuri:''' You're weak.
--> '''Karol:''' You're a hack!
--> '''Estelle:''' You're whack...teehee!
** Also there's poor [[VideoGame/TalesOfRebirth Veigue,]] who, after adding a dash of AscendedMeme and BigWordShout, can be depended on for a dramatic [[SayMyName KUREAAAAAAA]] in any cameo appearance. He doesn't do it in VideoGame/TalesOfGraces, however. For some reason, he's also lurking in the background of every single Tales of Theatre 5-minute short.
** There's also a random one poking fun at PerpetualFrowner [[VideoGame/TalesOfTheAbyss Asch]]. In ''VideoGame/TalesOfTheAbyss'' the eternally dependable [[DeadpanSnarker snark king]] Jade says "you look like you swallowed a bug...oh wait, you always look like that." And then in ''VideoGame/TalesOfVesperia,'' you can find a signboard that details the fighting styles of all the Abyss party members - but all [[GuestStarPartyMember Asch's]] entry says is "always looks angry."
** Much like ''Franchise/{{Gundam}}'' and their tendency to cast Creator/DaisukeNamikawa as their would-be Scrappies, ''Tales'' has a recurring gag to assign English dub VA Creator/LiamOBrien as the SmugSnake minor villain that could end up as a HateSink.
** [[VideoGame/TalesOfPhantasia Dhaos]]' susceptibility to the "Indignation" spell can be seen as this as well, with it always dealing severe damage and always making him shout ThisCannotBe when it's cast in any crossover game he's in. Even his expy Sekundes from VideoGame/TalesOfEternia ends up a victim of this.
* Starting with ''VideoGame/SimCity 2000'', most incarnations of ''VideoGame/TheSims'' franchise feature the phrase "Reticulating splines" each time [[LoadingScreen the game starts up]].
** ''VideoGame/SimCity'' also has a strange fascination with llamas, starting from the medium simulation speed setting in ''2000'' ("Llama"). ''3000'' had a llama giving you the Tip of the Day, in ''VideoGame/TheSims'' the minor-league team where you could play in the sports career is The Llamas, and the llama love is brought back in ''Sims 2: University'' (the llama is Sim State University's mascot). ''VideoGame/SimCity 4'' kicks this up a notch with a cheat code which turns your advisers into llamas.
** ''VideoGame/SimCity 3000'' also has running gags with kitty kibble shortage, broccoli (carried over to ''VideoGame/SimCity 4''), and FourthWall breakage.
** ''VideoGame/SimCity 4'', meanwhile, has running gags about you living a life full of luxuries.
** ''{{Spore}}'' has an homage to this line -- if you're loading a game in the Creature Phase, one of the phrases is "Reticulating ''spines''".
** ''The Sims 3'' continues with this running gag, as well as the one with Llamas.
* The reviewer [[TheSpoonyExperiment The Spoony One]] was pissed that ''[[http://www.spoonyexperiment.com/games/Thing/ The Thing]]'' PC Game had so many fuseboxes you had to waste time on to open doors, and had a "Fuse Box Count" that popped up whenever you saw one. Since then, it pops up whenever you see a fuse box ''in any other game''.
** He also reused the Hollywood Squares gag in his Let's Play of SWAT 4, shouting "You FOOL!" whenever the AI partners dropped a flashbang in his face.
* ''Franchise/AceAttorney'':
** Throughout the series, the characters debate on the correct denomination of a ladder (ladder or stepladder?) whenever you examine such a object. The ladders first appeared for flavour, then just for the sake of the RunningGag, and never had any relevance to the cases, except in the third case of ''Apollo Justice'', where examining a (step)ladder clues you into a possible escape route for the murderer.
** There's also a running joke in the first game about how difficult Edgeworth seems to find getting witnesses to state their names and professions.
** There is also Wright presenting the Attorney's badge, something that nearly every NPC in the first game reacts to (future games restrict this to giving reactions to only recurring characters), often questioning why he is doing so (possible joke at the process of TryEverything). Lampshaded in ''Apollo Justice''.
** And then there's Gumshoe telling him that real men wear a police badge.
** Detective Gumshoe and his constantly falling salary. [[spoiler: He gets it raised at the end of [=AAI2=]. He takes a while to understand what just happened.]]
** In AAI, we have Edgeworth always yelling "Nnnghoooh" during moments of distress. And Edgeworth will cringe at it every time Kay Faraday brings it up to make fun of him.
* In ''[[VideoGame/MarioAndLuigiSuperstarSaga Mario & Luigi: Superstar Saga]]'', no one knows who Luigi is, even Bowser, who calls him "Mr. Green Mario Brother Guy". Likewise, in ''VideoGame/PaperMario 2'', where Mario was repeatedly mistaken for '''Luigi''' in one side quest even Luigi's biggest fan thinks Mario (dressed in green at the time) is Luigi, which in a moment of hilarity the real Luigi shows up which the fan accuses Luigi of being the impostor and calls the police.
* In every game in the ''VideoGame/PaperMario'' series except ''VideoGame/PaperMarioStickerStar'', there is some variation of a group of wizards whose names all start with Merlon who always tell some sort of long, boring story, during which Mario falls asleep. When he wakes up, they ask "Are you even listening?" to which Mario replies with a nod.
** And there's also the tendency for important elderly characters to not say Mario's name right.
** PaperMarioTheThousandYearDoor had at least one NPC say Mario's name wrong, mistake him for someone else or have him go by an alias in each chapter, up until Chapter 7. Examples include the "Luigi" example mentioned above from Chapter 6, an elderly koopa mispronouncing his name as "Murphy" in Chapter 1, and Mario going by the alias "The Great Gonzales" in Chapter 3.
* The characters from the ''{{Atelier|Series}}'' series (and its {{spinoff}}, ''ManaKhemia'') seem to have an unhealthy fascination with barrels, and will shout "[[CaptainObvious Barrel!]]" every time the player examines one.
** This fascination is shared by Ashton Anchors of ''VideoGame/StarOceanTheSecondStory''.
** In ''VideoGame/AtelierIris2TheAzothOfDestiny'', Max [[AccidentalMisnaming never gets Felt's name right,]] saying things from "Frank" to "Frederico". Poe's womanizing counts for this too.
** Lampshaded in ''ManaKhemia2FallOfAlchemy'' and ''VideoGame/{{Atelier Annie|Alchemists of Sera Island}}''. In the former, Pepperoni and Goto (later replaced by Lily and Whim) surround a barrel in the Campus Grounds and notes "it's a barrel", while in the latter, a customer will lament the lack of barrel once your shop level is high enough.
* In ''VideoGame/SuperRobotWars'', the tendency of Elzam's {{Leitmotif}} '"Trombe!" to override all other songs is taken as a RunningGag by the producers. But then {{Flanderization}} took over, and due to the [[CrowningMusicOfAwesome awesomeness]] of the song, and it's no longer viewed as a RunningGag, but justified by the RuleOfCool. In the RPG spinoff ''EndlessFrontier'', there's a running gag involving Kaguya Nanbu being mistaken for or compared to a cow, due to her... huge tracts of land, and possibly her white-and-black outfit, including by what's essentially a minotaur. Who asks to ''marry her''.
** And there's the HeterosexualLifePartners relationship between Elzam and [[{{Badass}} Sanger]] [[EverythingsBetterWithSamurai Zonvolt]]. Taken UpToEleven where both get their respective {{Mid Season Upgrade}}s, and later on show through their mechs that "[[Memes/VideoGames Real Men Ride Each Other]]''...
* Sound designer Dan Forden's infamous "Toasty!" cry in the ''MortalKombat'' series.
* ''VideoGame/Left4Dead'' has [[http://www.youtube.com/watch?v=kc9f-VVQK3k Francis' hatred of everything he encounters]], which goes from where they are ("I hate forests", "I hate hospitals") to everything else ("I hate Creator/AynRand", "I hate the Internet"). He should probably [[MemeticMutation change his name]] to [[Film/{{Transformers}} Bonecrusher]].
** He eventually [[LampshadeHanging Lampshades]] this by saying "You know what I don't hate? I don't hate vests."
** Also lampshaded in Crash Course between Francis and Zoey:
--->'''Zoey:''' Francis, they have the latest issue of Hating Everything Magazine here!\\
'''Francis:''' I hate latest issues!
** ''VideoGame/Left4Dead2'': [[NoodleIncident Did ah ever tell you 'bout the time my buddy Keith...]]
** A survivor shooting a helicopter pilot because he was an infected and causing them to crash seems to be the running gag for the two Left 4 Dead games.
* ''VideoGame/HalfLife2'' has Barney Calhoun continually making [[NoodleIncident oblique references to some incident involving a cat and a teleporter]], possibly in homage to ''TheFly''.
** ''Half-Life 2'' also has a run-on joke from ''VideoGame/HalfLife1'', where guards would sometimes reply to "use" with "Catch me later, I'll buy ya a beer", and having Barney (the one personification of all the 'Barney' NPC guards throughout ''Half-Life'') tell the player "Now... about that beer I owe ya!" as his first line to the player after revealing himself.
* Mentions of Wirt's wooden leg in the Blizzard game ''VideoGame/{{Diablo}}'' have spread to the ''other'' Blizzard game ''VideoGame/{{Warcraft}}'' (and all sequels/spinoffs that follow).
* The ''{{Overlord}}'' series and pumpkins. In the original game, it was restricted to your minions being able to wear them as makeshift helmets and a farmer who treated them as sinister {{Companion Cube}}s. ''[[ExpansionPack Raising Hell]]'' upped the ante by adding [[AttackOfTheKillerWhatever Killer Pumpkins]] and the Mama Pumpkins that create them. From then on, pumpkins and characters bizarrely preoccupied with them have been a comedic fixture of the series. Gnarl put it best in ''Overlord: Dark Legend'' when he said "Damn pumpkins! Laying around all day... being orange."
* In the ''Franchise/SonicTheHedgehog'' series, starting with ''VideoGame/SonicAdventure2'', Amy thinks someone else is Sonic, runs up behind them out of nowhere, and hugs them, and seconds later Amy sees she was mistaken.
** It's somewhat less noticeable, but starting at ''VideoGame/SonicAdventure'', every now and then Sonic will fall from the sky, and land on his face. (While he did fall from the sky in ''Sonic 2'', he was caught by Tails.) ''VideoGame/SonicUnleashed'' even uses the gag as BookEnds to the story, while it's ''[[VideoGame/SonicStorybookSeries SonicAndTheBlackKnight]]'''s CrowningMomentOfFunny.
** Also, beginning in ''VideoGame/SonicUnleashed'', Eggman has a tendency to do his EvilLaugh before suddenly lapsing into a coughing fit.
** Ever since ''VideoGame/Sonic3AndKnuckles'', Knuckles has the tendency to believe in Eggman's lies that Sonic is the bad guy, leading him to fight against Sonic until he realizes that he's been duped by the evil scientist.
* Apparently, Nasu took a great deal of interest in the character popularity polls of ''{{Tsukihime}}'' and the fandom's reaction to certain characters who have been DemotedToExtra, becoming the source [[MemeticMutation jokes in the fandom]] and ran with it in ''Kagetsu Tohya''. The result? Ciel constantly [[BreakingTheFourthWall paints]] or outright breaks the fourth wall out of depression for her low popularity. In the side story Ciel Sensei, she eventually teams up with Kohaku (whose BatmanGambit nature was also downplayed and turned into a joke) against Arcueid because she's the only heroine to score lower in popularity. Satsuki is eventually kicked out because she never actually got heroine status and can't answer questions about her route.
* On the comp.sys.sinclair newsgroup, every "what is this game?" request will get at least one reply to the effect that "it's definitely not {{Stonkers}}". This is sometimes subverted, e.g. if the game described is a PlatformGame, someone might reply "it's definitely not VideoGame/JetSetWilly".
* ''KnightsOfTheOldRepublic'' has HK-47's "Meatbags!" and general [[ComedicSociopath insanity]], along with Mission's repeated use of [[TroublingUnchildlikeBehaviour "Bantha poodoo"]].
** In the second game, Atton makes an astute observation: "Why is it that everywhere we go, I end up in a cell?"
* In ''VideoGame/StarWarsTheOldRepublic'', Vette mentioning her fear of dying in whatever situation the Sith Warrior happens to be in.
* Given your [[RagtagBunchOfMisfits party's]] status as a walking band of racial stereotypes in VideoGame/NeverwinterNights2, some running gags are unavoidable: Khelgar's constant belligerent drunkenness, his constant insistence that Elanee is underfed, [[FishOutOfWater Shandra's]] constant complaints about being a farmer stuck on an adventure, and [[{{Cloudcuckoolander}} Grobnar]]. No more need be said about that last one.
* Most of the 3D ''[[Franchise/TheLegendOfZelda Zelda]]'' games have a running gag in which Ganondorf can be defeated with normal household items:
** ''VideoGame/TheLegendOfZeldaALinkToThePast'' let you beat Aganim [[spoiler:who was Ganon in disguise]] by deflecting his shots with a bug-catching net. It's back for ''VideoGame/TheLegendOfZeldaSkywardSword'', which lets you distract [[spoiler:Demise, the Demon King]] with a Bug Net again and deflect lightning.
** ''VideoGame/TheLegendOfZeldaOcarinaOfTime'' on the Nintendo 64 allowed you to swipe an Empty Bottle at Ganondorf's magic ball attack and deflect it, so you don't have to use a sword. ''VideoGame/TheLegendOfZeldaTheWindWaker'' repeats this against the Phantom Ganon fight. Finally, ''VideoGame/TheLegendOfZeldaTwilightPrincess'' allows you to distract Ganondorf by taking out your Fishing Rod, allowing you to get in some free hits.
** In most games, attacking the [[CallARabbitASmeerp cuccos]] will result in Link being mauled by an invincible army of them until he leaves the area. However, in ''Twilight Princess'', attacking them will allow you to swap bodies for ten seconds.
** Most Zelda games since ''A Link to the Past'' begin with Link being asleep and someone/something waking him up.
** In ''[[VideoGame/TheLegendOfZeldaSkywardSword Skyward Sword]]'', Fi always makes reference to the Bokoblins' obsession with "fashionable undergarments" when analyzing them.
** Tingle and his obsession with fairies and driving you bankrupt.
* ''VideoGame/FinalFantasyVIII'' has a subtle one: no one ever shakes Zell's hand. He'll offer and be ignored. Everyone else will get the offer to shake hands (Squall usually won't do it) except Zell. Later on, he can occasionally be seen wiping his hand off before offering it out, thinking his hand just might be dirty. However, wiping his hand on his butt ''in front of whoever he wants to shake hands with'' is not any more effective at getting someone to shake it. He's eventually put out by this, but, being Zell, shakes it off. He can't get any hot dogs either (flavored bread in the original).
* [[VideoGame/FinalFantasyVII Barrett's]] train metaphor comes up a few times, though it's only a memetic occurrence.
* For ''Franchise/FinalFantasy'' in general, we have Gilgamesh, a recurring PluckyComicRelief boss character that is technically the same guy from ''VideoGame/FinalFantasyV'' (Not a rehash, ''the same exact person''), just caught in the endless void of dimension hopping who shows up in other games in the franchise. Even those that were made before VideoGame/FinalFantasyV.
* The ''VideoGame/GrandTheftAuto'' games have several running gags within their in-game radio stations and commercials. These include:
** A war between the United States and Australia.
** "Freddy needs a nanny, because he's been a very naughty boy!"
** DJ/Talk show host, Lazlow (who's actually a real life talk show host who wrote some of the dialogue for the game), getting fired from one radio station and hired by another by the next game.
* ''Black Isle / Troika'' has regular instances of {{Squick}} / BlackHumor bestiality. VideoGame/{{Fallout 2}} has an omnisexual farmer's son. {{Arcanum}} has a sheep as a worker in a brothel (that the player can purchase the services of) and VideoGame/TempleOfElementalEvil has a cut content brothel that also included an option with a rooster.
* ''VideoGame/LinearRPG'' has Kliche waking up wet every single time.
* ''VideoGame/{{Bayonetta}}'' features [[spoiler:Enzo's car getting smashed up]] as one of these.
* It is guaranteed that any more games in the ''Franchise/DragonAge'' franchise are going to include Sandal standing in a room full of dead Darkspawn/demons including multiple Ogres and Pride Demons, and responding to any questions about what happened with "Enchantment!"
** Shale's hatred of birds, to the point of a shopkeeper in the second game telling Hawke a story about a massive decline in the Ferelden pigeon population.
** All the suggested/past offscreen references to Oghren taking his pants off, always reacted to with either shock or horror.
** Alistair's catchphrase "Swooping is bad" from the first game became this in the second. Whenever someone as much as used the word "swoop", somebody is bound to bounce it back (e.g. by Alistair's himself in his cameo and by Varric during his random banter with Merrill in the ''Legacy'' DLC).
* ''VideoGame/MassEffect2'' has a turian outside the Wards that repeatedly tries to get through the security checkpoint. Every one of his exchanges with the security officer ends with him saying [[HypocriticalHumor "You humans are all racist!"]]
** Similarly, the first game has the human trying to return a product at a shop in the wards.
*** He's still there in the second game. ''Two years later.''
*** In ''VideoGame/MassEffect3'', you can help him get his refund [[spoiler: for his 15-credit toaster]].
** Reporter Al-Jilani getting punched due to Shepard having had enough of her adjective nouns. In a bonus video from the Lair Of The Shadow Broker DLC, she gets punched out by a krogan. And, if you got back later, by a volus! BioWare must ''really'' hate reporters like her... In Mass Effect 3, she also tries to punch Shepard back. Shepard can respond by headbutting her.
** Any time you happen upon dead bodies with Grunt, there's a good chance Grunt will ask if anyone else is feeling hungry. Given a CallBack in the third game if [[spoiler: Grunt survives holding off the Ravagers]].
** Commander Shepard's dancing being ''hilariously'' atrocious.
** Javik's repeated CulturalPosturing towards the "[[WhileYouWereInDiapers Primitives]]" in this Cycle and telling Shepard to throw things out the airlock.
* In ''VideoGame/KingdomHearts358DaysOver2'', Roxas can't really go to [[TheNightmareBeforeChristmas HalloweenTown]] without getting a pumpkin bomb to the face courtesy of [[TerribleTrio Lock, Shock, and Barrel]]. Also, Ven's drowned goldfish.
* In ''VideoGame/{{Portal}}'', [[spoiler:The Rat Man]]'s obsession with cake. "TheCakeIsALie!"
** The garnishes on the cake, as listed by The Cake Recipe Core. Example: Volatile organic compound. [[RunningGag Shaped like fish. Tastes like rhubarb.]]
* ''VideoGame/{{Portal 2}}'' has ''truckloads'' of them.
** The automated announcer's comments about various "apocalyptic scenarios" during the first test chambers.
** [=GLaDOS=] taunting Chell about her adoption and ParentalAbandonment. This is also a CallBack to an offhand claim [=GLaDOS=] made in the first game. Similarly, [=GLaDOS=] taunting Chell about her supposed [[YouAreFat weight issues]]. Wheatley tries to get in on these gags later, only for [=GLaDOS=] to hilariously shoot him down.
** The Weighted CompanionCube is a running gag across the entire franchise, but in one particular test chamber, [=GLaDOS=] uses RuleOfThree to YankTheDogsChain by repeatedly disintegrating it.
** Chell being a HeroicMime and the other characters commenting on it. Similarly, Chell supposedly having brain damage from extended hibernation.
** Wheatley is a living fountain of running gags: catching him when he falls, his ineptitude at hacking, his inability to accomplish things without Chell's help, [=GLaDOS=]' insistence on calling him a moron/idiot, his ineptitude at designing test chambers, his ineptitude with {{Death Trap}}s, and more. Let's just say that his ineptitude in general is the biggest running gag of the entire game.
* ''{{Suikoden}}'' series has a few, most notably the "Schtoltenheim Reinbach III" pseudonym and [[TheDitz Viki]] sneezing and teleporting herself to another game events during the victory feasts at the end of the games.
* One of the missions in ''CityOfHeroes'' sends the player character(s) to rescue a Dr. Stephen Fayte, who is constantly being mistaken for a powerful sorcerer even though he is "merely a gifted surgeon, and nothing more." His captors repeat this phrase verbatim several times when he's found, as if they're under the influence of a JediMindTrick ... but that's impossible, for Fayte is merely a gifted surgeon, and nothing more.
* [[VideoGame/FinalFantasyX Tidus]] waking up on a new shore after [[BigBad S]][[LukeIAmYourFather i]][[TricksterMentor n]] attacked; it happens like 7 times over the course of the game. [[spoiler:It's also the manner in which he is revived in VideoGame/FinalFantasyX-2]].
* ''VideoGame/PokemonRanger: Shadows of Almia'' and ''Guardian Signs'' both repeatedly mention people being "bound up with rope tied a smidgeon on the tight side."
* ''VideoGame/HaloReach'' probably qualifies, given the number of times after a cutscene Noble Six is getting up off the ground and picking up a gun.
* ''Franchise/TheElderScrolls'' games begin with the main character locked in prison for some reason or another with alarming frequency. Usually you're freed by the Emperor to aid him in some manner. Subverted for once in ''Skyrim'', where instead of being locked up in prison, you're on your way to be ''executed''.
** If anyone mugs you, [[VideoGame/TheElderScrollsIIDaggerfall they're]] [[VideoGame/TheElderScrollsIIIMorrowind probably]] [[VideoGame/TheElderScrollsIVOblivion after]] [[VideoGame/{{Fallout 3}} your]] [[VideoGame/TheElderScrollsVSkyrim sweetroll]].
** In ''Morrowind'', there were three separate instances of nude Nord barbarians, as a result of them offending the witch they were escorting. Later spoofed in ''Tribunal'' when you found another nude Nord who was quite vocal about having never escorted a witch; he's nude because Mournhold is ''hot''.
** M'aiq the liar who shows up in every game from ''Morrowind'' onwards (either the original or his great great grandson) to make {{Fandom Nod}}s and TakeThat comments about the fans and [[TakeThatUs devs alike]].
* ''VideoGame/{{Fallout}}'' features a running joke and MythologyGag in the form of Harold, a FEV mutant with a tree called Bob [[ItMakesSenseInContext (or is it Herbert?)]] growing out of his head. He shows up again in ''VideoGame/{{Fallout 2}}'' and makes jokes and references to the first game. Finally in ''VideoGame/{{Fallout 3}}'' He shows up again, completely mad from his 200 years of life and still very friendly.
** ''VideoGame/FalloutNewVegas'' also has Cass and a few other NPC's who will make jokes and snide remarks about events from the second game.
* [[VideoGame/EarthBound "Say 'fuzzy pickles!'"]]
* News tickers during pre-mission cutscenes in the first two ''VideoGame/SplinterCell'' games make mention of a US Army general named Fisk, who suffers his third heart attack in the first game, and then his fourth and final one in ''Pandora Tomorrow''.
* Every single ''VideoGame/DragonQuest'' game has a reference to "Puff Puff", at least in the Japanese version. It's seldom spelled out directly, but in most cases implied to be MarshmallowHeaven.
** Additionally, every game that includes a Dharma Temple/Alltrades Abbey will have, somewhere in said Temple/Abbey, and old man who wants to be a young girl. It varies from game to game and translation to translation whether he simply wants to be a little girl or a BunnyGirl, though.
* ''Franchise/{{Pokemon}}'' main series games and their ever-present Fisherman with his team full of [[MagikarpPower Magikarp]].'
** "Shorts Kid", a variant of whom has showed up in every generation.
** Every game features a Hiker who starts each battle by laughing and ends it by telling you he has Hay fever
* ''VisualNovel/MajiDeWatashiNiKoiShinasai'' has several:
** One such example would be the dog whistles that each member of the family carries which, when blown, will have Wanko come running if she is within earshot. Unfortunately, this response is so deeply ingrained that her feet respond automatically, causing it to often be used against her, particularly when exam time comes around and there's studying to be done. Exploited for MoodDissonance during her route, when Yamato uses it to locate her after [[spoiler: she's [[TheRunaway run away from home]].]]
** The anime has one for Miyako starting episode 2 - each episode begins with an attempt by her to win Yamato's heart through increasingly ridiculous means, all of which fail.
* ''VideoGame/LiveALive'' includes a pair of son-father (son will always be called Watanabe or variations of thereof). In various timelines, the father will always have the worst of luck of being killed randomly and then his son would hilariously cry over his death and drag him away. They could be encountered naturally, or [[GuideDangIt require some tinkering in how you play]].
* ''Franchise/RatchetAndClank'':
** From ''Up Your Arsenal'' onwards, the series has a running gag in the form of Dr. Nefarious's unfortunate tendency to seize up and broadcast ''[[SoapWithinAShow Lance and Janice]]'', the plot of which becomes increasingly ridiculous with each new episode.
** ''VideoGame/RatchetAndClankFutureACrackInTime'': The Great Clock is located at ''the exact centre of the universe''... Give or take fifty feet.
* For some time now, the change list for every update in Minecraft has referenced Herobrine, a character from a creepypasta that reached [[MemeticMutation meme]] status in the community.
* Smith the horse in ''Franchise/{{Ultima}}'', who consistently will give you a hint to help you solve the previous game.
* The ''VideoGame/RealityOnTheNorm'' series has a human RunningGag in form of the crazy bum who keeps switching to a new identity every game. His identities include soldiers, aliens, fictional characters, a JewishMother, etc.
* An odd version of this from ''VideoGame/FireEmblemAwakening'', where the biggest version of it was actually the ''earliest'' and before the joke had been established! Kellam the Knight has a running gag in the game of being incredibly easy to overlook considering he wears massive amounts of armor. One character even comments [[LampshadeHanging "How can you be so stealthy in all that armor?"]] They routinely make references to this joke, from many of his spoken lines, to his supports and appearances in cut scenes, and even his epilogue. It even features in gameplay - he's the first character whom you need Chrom to talk to in order to recruit, and it's entirely possible for a player who doesn't know this to miss recruiting him entirely! Then if one takes a good look at the [[http://i.imgur.com/xd0pgJz.jpg cover art]] they see someone whose [[FridgeBrilliance face is mostly blocked by the main characters knee.]]
* In the [[VideoGame/NancyDrew Nancy Drew]] game series from Her Interactive, you seem to be following a still-unseen weirdo named Sonny Joon from one game to the next. Wherever an investigation takes you, doodling, UFO-obsessed Sonny is likely to have worked there, vacationed there, or corresponded with someone there, only to leave some time before your arrival. Also, references to Koko Kringles and [[AcmeProducts Krolmeister]] show up at least once in each game
* In [[SakuraWars Sakura Wars]], Erica Fontaine constantly bumping into things, complete with [[CirclingBirdies Circling Birdies.]]
* ''{{Final Fantasy XIII}}'': [[spoiler:Barthandelus]] knows exactly what [[BerserkButton buttons to push to piss the main party off]]. He manages to push [[IdiotHero Snow's]] button (his fiancee, [[AlwaysSaveTheGirl Serah]]) every time he is encountered, the result always being Snow charging head-on at him, only to be violently bounced back off a BeehiveBarrier. It works all three times. The man never learns.
* ''{{Pikmin}} 2:'' Louie is obsessed with food, to the extent that he is far more concerned with documenting the culinary uses of the various predators he encounters than working out how to survive when faced with them.
* ''VideoGame/{{Robopon}}'' has destroying Dr. Don's time machines every time you return from the past in the second game.
** Getting a Snorkel to breathe underwater. This happened in both games.
* The Kid's typical entrance into an area in {{Bastion}} is to just come flying in and [[{{Faceplant}} land right on his face.]] [[spoiler: It eventually stops being funny by the end of the game when, after a vicious beating by the Ura, the Kid returns to the Bastion in his usual manner...and then doesn't get back up.]]
* In every cutscene in ''[[Videogame/ASuperMarioThing A2XT]]'', [[ExpositionFairy Kood tries to explain the plot]], while Demo, Iris and raocow ignore him. Meanwhile, [[MyFriendsAndZoidberg Sheath was there too]].
* Dion in ''[[VideoGame/TearsToTiara2 Tears to Tiara 2]]'' continuously try to be popular with the girls, to no avail. Daphnis regularly makes offhand HoYay comments accompanied by an appropriate reaction from [[HappinessInSlavery his master]] [[BodyguardCrush and love interest Elissa]]. Kleito and Tarte keep arguing over worshippers. The final one is a ChekhovsGag.