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When Marge has to back out of taking Lisa to an ancient Egyptian exhibit at the museum so she can take Bart to Dr. Hibbert's office, Lisa tricks Homer into letting her ride the bus, but she boards the wrong one and must find her way home through a series of unfamiliar neighborhoods.
!! Tropes:

* AnAesop: Never be afraid to live life on the edge.
* AdultFear: Lisa being missing. Lenny and Carl have to spell Homer's blunder out to him.
--> '''Lenny''': [[WhatTheHellHero You sent your little girl downtown on a bus? Alone?]]
--> '''Homer''': Maybe. But you don't know Lisa. I mean, she's so smart they hooked her up to a big computer to try to teach it some things. But she had so much knowledge, it overloaded. And then it got really hot and caught on fire!
--> '''Carl''': That never, uh, happened, did it, Homer?
--> '''Homer''' [[OhCrap Uh, yes]]. But now I have to leave on a totally unrelated matter. ''(runs out of the cafeteria)'' Oh, Lisa!
* {{Area 51}}: Or rather, Area 51-''a''.
--> [[NoSuchAgency "You are here.]] [[IWasNeverHere We are not."]]
* {{Balloonacy}}: Subverted when Homer needs to get up high to spot Lisa. "Oh, I hope this works...these are for you if you let me use your cherry-picker."
* BaitAndSwitch: As mentioned above Homer decides that he needs to get up high to be able to scan the surrounding city for her and then goes to a vendor selling balloons, seemingly leading up to a joke that Homer is dumb enough to think he could float using a handful of balloons.... Then, he offers the balloons to a cherry pick driver in exchange for using his machine to lift him up. It works.
--> "Well, I've already got some balloons - but they're not this nice. Deal!"
** Later Homer runs into Mr Burns while looking for Lisa
-->'''Mr Burns:''' Shouldn't you be at work?
-->'''Homer:''' (Nervously) Yes sir... Mr Burns... sir.
-->'''Mr Burns:''' Then go back to wherever it is you work, whoever you are.
** Later still
-->'''Homer:''' I'm not much of a praying man, but if your up there please save me {{Franchise/Superman}}!
* BilingualBonus: The signs in the Russian district of Springfield are actual Cyrillic words and the Russian the chess players speak is real.
* ChewToy: Homer. His quest starts with him trying to save Lisa, and it ends with his head caught between two halves of a drawbridge.
** Lisa herself is put through the wringer the moment she tries to take a bus.
* EarWorm: In-universe. The music from the Orb of Isis for Homer, even if he gets the tune wrong.
* FreezeFrameBonus: In the joke shop there are labels reading itching powder, hart-attack powder and [[TheLoinsSleepTonight impotence powder]]
* {{Jerkass}}: All Larry the Bus Driver did to help Lisa out is tap the sign that says "Do not talk to driver", even after she truly becomes lost and frightened, before abandoning her in the desert.
* MoodWhiplash: The nice moment when Homer and Lisa discover the secret of the Orb of Isis is quickly ended when they trigger the alarms and have to escape, right at the end of the episode.
* NeverTrustATrailer: The promos for this episode made it out to be about Bart having to live with gag props stuck to his face thanks to using Homer's industrial-strength glue, but that subplot came to an anticlimactic end when Dr. Hibbert made Bart sweat to get the adhesive to loosen up.
* NiceJobBreakingItHero: Homer accidentally damages the Orb of Isis: subverted when dropping it revealed a music box with a pretty tune.
* NightmareFuelStationAttendant: Dr Hibbert suggests getting the superglue off Bart's face with a series of painful injections in Bart's spine as it turns out this was just to get Bart to sweat to loosen it up. When Bart ask why he couldn't have just turned the heat up he replied that it had to be TERROR sweat.
* NoIndoorVoice: The Russian man Lisa asks for directions
* NoSympathy: Larry the Bus Driver has a personal sign for all of his passenger's woes. "Do not talk to driver."
-->'''Larry:''' Don't make me start tapping this...
* SkewedPriorities: Bart refuses to put dog doo on his face, because its been on the dirty ground.