Mrs. Krabappel leaves Skinner at the altar and starts dating Comic Book Guy.

!! Tropes:
* CallBack:
** Milhouse dresses as Fallout Boy at the convention, having previously been cast as Fallout Boy in the failed film production of "Radioactive Man" during the eponymous episode.
** After Edna and Skinner break up, Skinner laments, "Bart's right, I am a wiener." This a reference to the graffiti Bart made back near the beginning of the first season.
* CreatorCameo: Creator/MattGroening appears at the convention, in what essentially amounts to a two-minute promo for ''WesternAnimation/{{Futurama}}''.
* {{Jerkass}}: Moe got Barney off the wagon so he could make more money off him.
* LiteraryAllusionTitle: The title is an allusion to ''Film/MyBigFatGreekWedding''.
* NerdsSpeakKlingon: When Comic Book Guy tries to get married to Edna Krabappel it is conducted in Klingon; apparently the guests (sci-fi convention attendees) can all understand it.
-->'''Comic Book Guy''': Edna, the Klingons have a romantic saying. (''speaks Klingon'') Roughly translated it means I would kill the children of a thousand planets just to see you smile.\\
'''Edna''': Oh, that is the most romantic thing I've ever heard. Which is kinda sad if you think about it.
* OhCrap: Groundskeeper Willie's reaction to seeing shredded red material coming out behind his tractor.
-->'''Groundskeeper Willie''': Oh my God! I've shredded a child! '''''[[NoodleIncident AGAIN!]]'''''
* ScrewThisImOuttaHere: Willie's response to having potentially killed a child (albeit inadvertantly): head for the border.
-->'''Groundskeeper Willie''': Venezuela, here I come!