'''Airdate:''' May 2, 2010

In this ''FamilyGuy'' take on the ''AllInTheFamily'' episode, "Archie in the Cellar," Brian and Stewie are locked in a bank's vault for the weekend and, after a disgusting ordeal involving a soiled diaper, begin to bond -- and Stewie learns a horrible secret about Brian.
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!!"Brian & Stewie" contains examples of:
* BorrowedCatchphrase: At one point, Stewie says "Giggity".
* BottleEpisode, VerySpecialEpisode, and SomethingCompletelyDifferent: It's the only ''FamilyGuy'' episode (so far) to have no cutaway jokes, flashbacks, or any of the typical ''FamilyGuy'' humor (besides [[spoiler: the infamous diaper-eating sequence]]) nor does it have any other voice actor besides SethMacFarlane, or any music or musical numbers (though when it first aired as part of the "FOX Rocks" line-up, the episode immediately after that was a ClipShow of the series' different musical numbers), it takes place in one setting (SethMacFarlane has stated that he wanted to do this episode like a ''WaitingForGodot''-style play), and is one in a handful of episodes that's more dramatic than funny (see also: "Screams of Silence: The Brenda Q. Story," "Brian Wallows and Peter's Swallows," and "Partial Terms of Endearment").
* {{Bowdlerization}}: On the TV version, a lot of the "Diaper-eating scene" and references to it had to be edited (and, like most other ''FamilyGuy'' episodes, the uncut version -- with the original lines and unbleeped swearing -- can be found on DVD).
* DrivenToSuicide: It's revealed Brian has a gun so he can kill himself because he feels his life is not worth living.
* IronicEcho: "Oh I'm just callin' like I'm seein' it!"
* OhCrap: When Brian realizes that his acts of eating Stewie's poop and licking his butt have been caught on tape by a security camera.
* SickAndWrong: Brian in regards to Stewie asking him to eat his poop.
-->'''Brian:''' That's ''sick!'' That is sick! How messed up in the head are you that you'd even ''ask!?''
* SkewedPriorities: Stewie's cell phone had just enough battery life for one call... which he wastes trying to return his sweater.
* WhamLine: Brian's admission that he keeps a gun for if he ever wants to kill himself comes fresh off of Stewie making perverted jokes about it.
* YouMonster: Brian says this when Stewie reveals that he made him eat his poop because [[ItAmusedMe it amused him]].
-->'''Brian:''' You son of a bitch, it could kill you for that!