'''Airdate:''' January 13, 2008
When Peter looks through Cleveland's mail while he's out of town, Peter discovers the magazine ''Mustache Aficionado'', which inspires him to grow his own mustache. Peter enjoys life with a mustache until he and Brian see that the local [=McBurgertown=] restaurant is on fire. Since Peter has a mustache, the firemen get him to man a hose, but when Peter hears someone yelling for help inside the restaurant, Peter goes in and saves him, but burns his mustache off in the process. To compensate for his mustache, he tapes Brian to the front of his face. The man he rescued comes to the house, revealing that he owns the restaurant and because Peter saved his life, he is offered a lifetime supply of [=McBurgertown=] hamburgers. Peter and Brian go to the restaurant, where Peter eats more than 30 hamburgers, causing him to suffer a stroke, paralyzing the entire left side of his body.
Peter attempts to live his usual life with his new droopy body, but finds it extremely hard and he vows to get back at [=McBurgertown=] for making him "strokey" (despite it being his own fault he had the stroke). When he discovers a stem cell research lab, he goes in to get an injection and instantly returns to his normal self. Peter than attempts to sue [=McBurgertown=] Industries and fails, with Brian telling him that he can't take on a multi-million dollar fast food conglomerate. Peter still plans to ruin them and he and Brian sneak into [=McBurgertown=] Headquarters, where they discover the slaughterhouse and meet a genetically-engineered talking cow. The cow agrees to speak out against the restaurant's business practices and after a chase with security, Peter, Brian and the cow escape. As the Griffins watch the cow's speech of TV, he becomes disappointed that Peter won't let him stay in his house.
Meanwhile, Stewie is outraged by the teenagers on ''OneTreeHill'' and makes a bet with Brian that he can sneak into James Woods High School and become the coolest kid in school within a week. He goes in under the name "Zach Sawyer" and instantly wins over Connie and the cool kids, as well as scoring a date with Connie. When he plans to have sex with Connie in the car, she instead laughs at him for his "baby penis" and tells everyone in school, causing "Zach" to lose his popularity. As revenge, Stewie gets Connie to kiss him and undresses himself, getting her framed for pedophilia and arrested. He then walks out of the school naked strutting his butt.
!!"[=McStroke=]" contains examples of ([[YMMV/FamilyGuyS6E8McStroke YMMV goes here]]):
* ActorAllusion: The cow, voiced by Ricardo Moltalban, says that many cows were killed, including...[[Film/StarTrekIITheWrathOfKhan "my beloved wife"]].
* AlphaBitch: Connie D'Mico
* BackstabbingTheAlphaBitch: See LaserGuidedKarma below.
* AuthorTract: When Peter gets cured with stem cells.
-->'''Peter:''' How long was I in there?
-->'''Guard:''' About five minutes.
-->'''Peter:''' ''Why aren't we funding this!?''
* BurgerFool: [=McBurgertown=].
* IAmWhatIAm: Stewie tells everyone this before strutting out of school.
* IGaveMyWord: Peter says this when he promises the [=McBurgertown=] executive not go into a secret room, which Brian has to talk him out of.
* LaserGuidedKarma: Stewie tricks Connie into kissing her and frames her for pedophilia, getting her arrested.
* MidBattleTeaBreak: When Brian and Peter rescue a talking cow, they're chased by 2 guards. The Montage show them all in a band, playing music together.
* NeverMyFault: Brian points out that it's bad for Peter to sue [=McBurgertown=] because it was his own fault he had a stroke by eating all those burgers.
* ScoobyDoobyDoors: Used in the chase scene.
** [[SpiderMan "With great mustache comes great responsibility!"]]
** The chase scene with Peter, Brian, the cow and the security guards is set to [[TheMonkees "Pleasant Valley Sunday"]].