'''Airdate:''' March 2, 2008

Peter and Lois have been having marital troubles lately, with Peter preferring to out with his friends rather than go on quiet outings with his wife. Brian, meanwhile, has won a literary contest and has been invites to accept an award at Martha's Vineyard. He decides to invite Peter and Lois in hopes of easing their marital stress. When they arrive, Peter quickly enjoys himself getting drunk and spending even less time with Lois. Lois finally snaps at Peter when he misses Brian's acceptance speech and arrives right after completely intoxicated.

Since Peter has already made plans for himself, Lois decides to spend the day with Brian and they have a wonderful time together. As they get ready to spend the evening together in her room, Brian starts having fantasies about declaring his love for her and kissing her. That night, Brian tries to keep himself together, but he loses it and attempts to kiss Lois. An angered Lois then kicks him out. When Lois tells Peter what happened the next morning, he confronts Brian at a bar, where Brian calls him out, telling him he's not good enough for Lois, with Peter calling Brian out for not having any long-term relationships with women he dates. The argument quickly escalates into an all-out brawl between the two, but Nathan Lane (whom Peter had accidentally married) breaks the fight up. Peter and Brian reconcile and they promise each other not to let Lois come between their friendship again. Later, Brian comes to apologize to Lois and she says that even though she does have feelings for him, she chooses to remain faithful to Peter.

Meanwhile, while Peter, Lois and Brian are away, Herbert is hired to babysit the kids and as usual, he tries to advance onto Chris. While he reads Chris a bedtime story, Chris finally asks if Herbert's a pedophile ([[TheUnreveal though the episode ends before the viewer gets a "yes" or "no" answer]]).
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!!"Play It Again, Brian" contains examples of ([[YMMV/FamilyGuyS6E10PlayItAgainBrian YMMV goes here]]):
* BaitAndSwitch: Herbert is shown coming on to Chris asking if he can scrub him during his bath. Meg ends up doing it.
* BarBrawl
* BrickJoke: Peter mentions a drunken shenanigan where he married Nathan Lane (not knowing gay marriage is legal in Massachusetts). Lane later appears to break up Peter and Brian's fight.
* BringMyBrownPants: Lois spends the night with Brian after reading a note from Peter saying he's going to get some new pants after crapping his old ones laughing while watching ''ThreesCompany''.
* CallBack: The GregoryPeck joke from "Saving Private Brian" reappears while Lois and Brian are watching ''RomanHoliday''.
* TheCastShowoff: "As Time Goes By" is performed by SethMacFarlane, further exposing his wonderful singing talent.
* FallingInLoveMontage: Lois and Brian's day together, with [[{{Film/Casablanca}} "As Time Goes By"]] playing.
* GroinAttack: Brian gives Peter one during their brawl.
* {{Jerkass}}: Peter.
* MyGodWhatHaveIDone: Brian after he tried to kiss Lois, even calling himself a rapist.
-->'''Brian:''' I'm no better than Kobe Bryant or Mike Tyson or [[RonaldReagan Reagan]].
* NoHoldsBarredBeatdown: Peter and Brian give one to each other during their brawl.
* TheReasonYouSuckSpeech: Brian gives one to Peter for being selfish and negligent to his own wife.
* RecursiveCanon: Lois and Brian win a Stewie doll at a carnival.
* ShoutOut
** In a street painting, Lois and Brian are caricatured as [[TheJetsons Jane Jetson]] and [[{{Peanuts}} Snoopy]] in yet another joke about how animation is built on plagiarism (which ''TheSimpsons'' -- a show that has a lot of imitations, like ''FamilyGuy'' itself -- has taught viewers with the season seven episode "The Day The Violence Died").
** Stewie carved [[TheShawshankRedemption "Brooks was here"]] in Lois' birth canal.
** [[{{Peanuts}} "Aw rats!"]]
** [[AnimalHouse "Was he bigger than me?"]]
* TheStinger: During the credits, the Evil Monkey comes out of the closet, but when he notices Herbert sleeping, he slowly backs away into the closet.
* TakeThat
-->'''Lois:''' How about we just order room service and watch a couple of bad movies?
-->'''Brian:''' Yeah, that does sound like fun. I'll go rent ''VanillaSky''.
-->'''Lois:''' I said a bad movie, not an abortion.
* TriumphantReprise: "The Spirit of Massachusetts" was earlier heard in a CutawayGag parodying Massachusetts tourism commercials and at the end, is sung as a CrowdSong.