* ''Webcomic/TheAdventuresOfDrMcNinja''
** [[http://drmcninja.com/page.php?pageNum=16&issue=9 This]] page, as shown in the page image.
** Later on, [=Dan McNinja=] has to hunt down the last surviving member of the Belstein family, whose bloodline is the only thing that can defeat a powerful demon. It turns out that the [[spoiler:Belsteins had to engage in massive inbreeding to keep the bloodline "pure" so someone could fight the demon... and the last living Belstein is a crippled invalid thanks to that.]]
* [[http://forums.penny-arcade.com/discussion/comment/7957613/#Comment_7957613 This]] comic on the ''Webcomic/PennyArcade'' forums.
* A common occurrence on ''Webcomic/{{Shortpacked}}''. RuleOfFunny will be enacted, then in the next comic the serious results will hit the characters.
** Perhaps the best example of this was when Sydney Yus got herself elected to Congress specifically so she could introduce a bill to shut down the titular store... only to be bluntly informed that she is a federal representative, and that is a state-level matter. "Curses! Trapped in a prison of my own making!"
* In ''Webcomic/FriendlyHostility'', Collin gets a part time job as a funny kids show host. When he's publicly outed as being gay, it's shrugged off as a joke at first, until he realizes it will cost him his job. He becomes severely depressed and ends up breaking off his relationship with Fox, and although they try to work it out with a therapist, later canon shows that they never get back together. [[DownerEnding End of comic]].
* In ''Webcomic/{{Sinfest}}'', there's a Reality Zone. Inside it, characters are drawn with a much more realistic style, and all the normal rules like RuleOfFunny or RuleOfCool no longer apply, with characters instead being forced to face reality. The Devil and other supernatural characters all avoid the place like the plague, for example, and Squig (an anthropomorphic pig) turns into an ordinary pig when he enters.
* [[http://buttersafe.com/2010/06/08/so-sleepy/ This]] ''{{Buttersafe}}'' comic.
* ''Webcomic/{{xkcd}}'' had [[http://xkcd.com/347/ Breakout]]: DontTryThisAtHome.
** Xkcd [[http://xkcd.com/652/ does this]] [[http://xkcd.com/734/ quite a bit]].
* In ''NipAndTuck'' the ShowWithinTheShow ''Rebel Cry'' opens with LaResistance getting its head handed to it by TheEmpire, because it consists of two systems.
* In ''Webcomic/TheOrderOfTheStick'', [[{{Cloudcuckoolander}} Elan]]'s use of bardic music to help Roy bluff an ogre warns the ogre that they are bluffing.
** In [[http://www.giantitp.com/comics/oots0326.html this strip]], a Hydra is attacking by having its heads cut off. This normally wold be an idiotic tactic, as the Hydra grows two heads for every one cut off, but the incessant chopping proves too much for the beast. Why? The Hydra grows so many heads that it can't give enough blood to them all and passes out.
** During the Fall of Azure City arc, Daimyo Kubota, a [[CardCarryingVillain card-carrying]] [[AristocratsAreEvil evil aristocrat]], continually schemes to [[TakeOverTheCity take over Azure City]], and still plots to assassinate its lawful ruler even after its entire population has been displaced and their home conquered by an army of goblinoids. Eventually, an overstrained and frustrated Vaarsuvius [[http://www.giantitp.com/comics/oots0595.html disintegrates him, rather than waste time on a legal trial that would probably have ended up in his favor anyway]], after he is caught in the aftermath of yet another disruptive scheme -- in this case, trying to murder two commoner-blooded warriors who had been newly elevated to noble status for their valor during the siege of Azure City.
* Occurs in ''Webcomic/TheDreadful,'' for a given value of "[[ImprobableAimingSkills reality]]". A posse shows up at Kit's hideout. Their [[SmugSnake arrogant]] leader threatens and insults Kit while flipping his gun around [[VideoGame/MetalGearSolid Revolver Ocelot]]-style. It looks like an epic gunfight is about to ensue, but Kit simply shoots the hammer of his gun mid-flip, causing it to shoot him in the head.
* At the end of one ''FruitIncest'' story arc, Sarah gives everyone a TrueMeaningOfChristmas speech, which later inspires Bernard to leave Simon alone so everyone can enjoy the holidays together. Much later it's revealed that letting a wanted criminal escape doesn't look very good on your resume, Christmastime or not. The Elf Council blames Bernard for all the previous events and unofficially demotes him and his entire group for their negligence.
* In Atticus's first Gym Battle in ''Webcomic/{{Mokepon}}'', he sends out a Pikachu to fight an Onyx. Sending a cute yellow rat against a fifty-foot rock snake ends [[http://mokepon.smackjeeves.com/comics/1554260/chapter-5-page-42/ about as well as you'd expect.]] This also plays into the ElementalRockPaperScissors; Pikachu is an Electric Type with mainly Electric and Normal attacks, while Onix is a Rock and Ground type that resists Normal attacks and is immune to Electric type attacks.
* In ''{{Webcomic/Zelfia}}'', Mayy's birth mother [[MosesInTheBullrushes leaves her infant daughter on the doorstep of a human florist]]... who promptly calls Child Protective Services and puts the baby into the foster care system.
* [[http://www.vgcats.com/comics/?strip_id=207 This]] Webcomic/VGCats parody of WesternAnimation/TomAndJerry.
* ''Webcomic/DarthsAndDroids'' demonstrates that people from all over the galaxy [[http://www.darthsanddroids.net/episodes/0876.html will naturally speak different languages]], even if they're all the same race. It also shows the fact that a struggling rebellion strapped for cash [[http://www.darthsanddroids.net/episodes/0891.html might not have access to the best-quality resources]].
** During Episode 3, it shows that [[http://www.darthsanddroids.net/episodes/0484.html heroes do not get off the hook]] for collateral damage in a harsh aversion of NoEndorHolocaust.
-->'''Mace Windu''': I don't know whether to kick you out of the Jedi Order, court-martial you, or ''just execute every mother-frakking last one of you''.
-->'''R2-D2''': [[BlatantLies It wasn't my ship!]]
* [[http://tenshi-no-hikari.deviantart.com/art/Sasuke-it-was-about-time-155837517 This]] ''Manga/{{Naruto}}'' fancomic.
* In ''Webcomic/GirlGenius'', it turns out that [[http://www.girlgeniusonline.com/comic.php?date=20131127 severed clank limbs need to land somewhere.]]
* In ''Webcomic/ManlyGuysDoingManlyThings'', Jared the intern bought and ate [[ManChild $500 worth of gummy bears]]. He then had to get his stomach pumped.