->''"There's no scientific consensus that ''life'' is important!"''
-->--'''Professor Farnsworth''', ''WesternAnimation/{{Futurama}}''

->''"He is a man of good birth and excellent education, endowed by nature with a phenomenal mathematical faculty. At the age of twenty-one he wrote a treatise upon the binomial theorem which has had a European vogue. On the strength of it, he won the mathematical chair at one of our smaller universities, and had, to all appearances, [[YouCouldHaveUsedYourPowersForGood a most brilliant career before him]]. But the man had hereditary tendencies of the most diabolical kind. A criminal strain ran in his blood, which, instead of being modified, was increased and rendered infinitely more dangerous by his extraordinary mental powers. Dark rumours gathered round him in the University town, and eventually he was compelled to resign his chair and come down to London... He is the Napoleon of crime, Watson. He is the organiser of half that is evil and of nearly all that is undetected in this great city."''
-->--'''SherlockHolmes''' on '''Professor Moriarty''', "The Final Problem"

->'''Doctor:''' Just one ''small'' question, ah... why do you want to blow up the world?
->'''[[HerrDoktor Zaroff]]:''' 'Why?' You, a scientist, ask me why? The ''achievement'', my dear Doctor! The destruction of the world! The scientists' dream of supreme power!
-->--''Series/DoctorWho'', [[{{Recap/DoctorWhoS4E5TheUnderwaterMenace}} "The Underwater Menace"]]

->'''Buzz:''' Evil Dr. Porkchop!
->'''Hamm''': That's [[TheyCallMeMisterTibbs MISTER]] Dr. Porkchop to you!
-->--''WesternAnimation/ToyStory2''

->''"Edward Bailey was a genius physicist who built some of the greatest stuff during the Cold War: neutron bombs, particle beam weapons, nerve gas weapons--''excellent'' nerve gas. He was a rock star of conventional mass killing. They called him '[[MadArtist The Da Vinci of Death]]'."''
-->--'''Marvin''', ''[[{{Film/Red}} Red 2]]''

->''"Can you believe it? Wimpy old Professor Warren--and look at me! Able to take on not one, but two [[SpiderMan Spider-Men]] at the same time! I'd like to see the nitwits at NSU deny me tenure now! "''
-->-- '''The Jackal''', ''TheCloneSaga''

->''"Dr. Francois Duvalier was the former President for Life of Haiti, a title which he gave himself because that's the kind of thing you do when you're a crazy dictator. His father was named Duval Duvalier and was [[HangingJudge a judge]] while his mother, Ulyssia Abraham, was [[InTheBlood insane]]. The only thing missing was [[FreakLabAccident exposure to radiation]] to help him on his way to perfecting his villainy."''
-->--'''''{{Website/Cracked}}''''', [[http://www.cracked.com/article_16611_5-real-world-criminals-who-were-certified-supervillains.html "5 Real World Criminals Who Were Certified Supervillains"]]

->''"I swear I’m not just saying this over bitterness over [[SuspiciouslySpecificDenial my own botched attempt to get an academic PhD]], honest: I find it really pretentious when people who have non-medical doctorates go around calling themselves 'doctor.' Maybe [[DoctorOctopus Doc Ock]] wanted to call himself 'Professor Octopus' but then he got an angry letter from the provost reminding him that he was only an adjunct lecturer."''
-->--'''''TheComicsCurmudgeon''''' [[http://joshreads.com/?p=22585#comments on]] ''Spider-Man''

->''"Are there really a lot of people named 'Dr. Hell?'"''
-->-- '''Sabrina''' on ''[[Anime/MazingerZ Dr. Hell]]'', ''VideoGame/PokemonRedAndBlue''

->''" Scotland Yard has top man working on the case: [[IdenticalGrandson James Xavier]], whose head appears to be emerging from a bear trap made of hair. Xavier, whose voice sounds eerily familiar, believes that the culprit behind these… crimes? is one Nathaniel Essex, but the cops refuse to believe him. See, Essex is in his sixties, but the culprit is clearly a younger man. Also, the cops are wary of charging a respected [='=]''man of science''[='=] with these crimes, which is understandable. I mean, who ever heard of an evil scientist?"''
-->--'''Chris Sims''' [[http://comicsalliance.com/the-x-men-episode-guide-5x12-descent-or-literally-no-one-cares-about-minister-sinister/ on]] ''WesternAnimation/{{X-Men}}'' ("Descent", or "No One Cares About Mister Sinister")
----