->''So! You will help me find that treasure right Mario? The boat's waiting for you!''
-->-- '''Princess Peach''', ''VideoGame/PaperMarioTheThousandYearDoor'' (at the end, of course)

->''"Here I go again on my own, going down the only road I've ever known..."''
-->-- '''Music/{{Whitesnake}}''', "Here I Go Again"

->''Um, did he just bring them back? Did— did he just save the world from aliens, and then '''bring all the aliens back again?!'''''
-->-- '''Rory''', ''Series/DoctorWho'', "The Eleventh Hour"

->''Is this what it all comes to? Not much now. To think that it brought civilization right to the brink. A giant step backward in man's evolution toward eternity and redemption—''the ultimate scientific nightmare!'' I can't believe the politicians would ''dare'' to tempt fate again...''
-->-- '''Colonel Shikishima''', ''Anime/{{Akira}}''

->''Aw, jeez, here we go...''
-->--'''Pikachu''', ''Film/PokemonDetectivePikachu''

->''How do I always end up back in this damn city?''
-->--'''Kazuma Kiryu''', ''VideoGame/Yakuza6''

->'''Harold:''' Oh, NO!\\
'''George:''' Here we go again!
-->-- The ending of every ''Literature/CaptainUnderpants'' book ever (except for the last one), as well as [[WesternAnimation/CaptainUnderpantsTheFirstEpicMovie the movie adaptation]].

->'''Scoops:''' Looks like everything is back to normal!\\
'''Dr. Toodles:''' "Normal?" Well, now... I wouldn't say that! (EvilLaugh)
-->--'''WebAnimation/OllieAndScoops''', ''"Gimme a Hand"''

-> ''"It's been one of those days..."''
-->-- '''Mario''', ''VideoGame/HotelMario''

->''"Ah shit. Here we go again... Worst place in the world. Rollin' Heights Balla Country. I ain't represented Grove Street in 5 years, but the Ballas won't give a shit."''
-->-- '''Carl "CJ" Johnson''', in an inversion of the trope, ''VideoGame/GrandTheftAutoSanAndreas'', "In The Beginning"

->'''Franklin:''' Oh, shit. Here we go again.\\
'''Lamar:''' That's that LD Organics, nigga. That's the bomb...\\
'''Franklin:''' ...the bomb... Man, this shit fire.\\
'''Lamar:''' Work like a charm every time, nigga. Come on, man.\\
'''Franklin:''' Fuck...
-->--''[[Videogame/GrandtheftautoV Grand Theft Auto Online]]'', "Fire It Up"

->'''Tali:''' Commander Shepard, this is Admiral Zaal'Koris vas [[EmbarrassingLastName Qwib-Qwib.]] (''sotto voce'') Do not ask about the name.
->'''Shepard:''' You have a ship named Qwib-Qwib?
->'''Tali:''' [[ThisIsGonnaSuck Ohh, here we go...]]
-->--''VideoGame/MassEffect2''
----