->"What kinda gas is dis?! ''Eeeyagh!'' What happened to my voice?! I sound like one of [[Franchise/AlvinAndTheChipmunks the Chipmunks]]!"
-->-- '''Meowth''', ''Anime/PokemonTheSeries''

->"My favorite element is helium. ''I can't speak highly enough of it!"''
-->-- '''Hugh Dennis''', ''Series/MockTheWeek'', "Things you wouldn't hear on a science documentary"

->"Kripke, I found the nozzle! I am going to kill you!"
-->-- '''Sheldon Cooper,''' ''{{Series/The Big Bang Theory}}''

->They answered with a war cry that would have sounded impressive if their voices weren't so squeaky from the oxy-helium mix.
-->-- ''Fanfic/RocketshipVoyager''

->"Wait," Aeneas commanded. The helium in the atmosphere in the [[SpaceStation station]] made his voice shrill, but the [[AuthoritySoundsDeep timbre of command remained]].
-->-- ''High Justice'' by Creator/JerryPournelle

->'''John:''' ''(squeaking)'' What just happened?
->'''Rygel:''' ''(in a defensive, gravelly soprano)'' It's a [[BizarreAlienBiology perfectly natural bodily function!]] And it's odorless!
->'''D'Argo:''' ''(like an infuriated Munchkin)'' So your loyal subjects tell you!
->'''John:''' ''(incredulous)'' You fart helium!?
->'''Rygel:''' Sometimes. When I'm [[BringMeMyBrownPants nervous]]...or angry!
-->-- ''Series/{{Farscape}}'', "Premiere"
----