->"They look like big, good, ''strong'' hands. Don't they? I always thought that's what they were. My little friends. The little man with his racing snail, the Nighthob, even the stupid bat. I couldn't ''hold on'' to them. The Nothing... pulled them right out of my hands. I failed."
-->--'''Rockbiter''', ''Film/TheNeverendingStory''

->"The world[[DramaticPause ...]]is a dark and lonely place."
-->--'''Ryouga Hibiki''', ''[[Manga/RanmaOneHalf Ranma 1/2]]''

->'''Beavis''': Dammit, this always happens! I think I'm gonna score, and then I never score! It's not fair! We've traveled, um, a hundred miles 'cause we thought we were gonna score! But now it's not gonna happen! Dammit!\\
'''Bus Driver''': Hey, buddy, sit down!\\
'''Beavis''': Shut up, ass-wipe! I'm sick and tired of this! We're never gonna score! It's just not gonna happen! We're just gonna get old like these people, but they've probably scored!\\
'''Bus Driver''': Hey, I'm warning you! SIT DOWN!\\
'''Beavis''': It's like, this chick's a slut! And look at this guy - he's old, but he's probably scored a million times!\\
'''Old Guy''': Oh, yeah!\\
'''Beavis''': But not us! We're never gonna score! We're never gonna score! WE'RE NEVER GONNA SCORE!
-->--''[[WesternAnimation/BeavisAndButtheadDoAmerica Beavis and Butt-Head Do America]]''

->"Some savior I am... I couldn't even save [[spoiler:Yurin.]] I... [[DeathWail I...!!!]]"
-->-- '''Flit Asuno''', ''Anime/MobileSuitGundamAGE''

->''Don't push me,''\\
''Cuz I'm close to the edge''\\
''I'm trying not to lose my head...''
-->--'''Music/GrandmasterFlashAndTheFuriousFive - ''Music/TheMessage'' '''

->''"I would like to see my brother."''\\
''"I'm sure he's very busy."''\\
''"Yes....[[BreakTheCutie yes.]]"''
-->--'''[[Series/{{Firefly}} The R. Tam Sessions]]'''

->"Five years ago, I [[NukeEm lost thirty thousand men in the blink of an eye]]....[[ApatheticCitizens and the world just]] '''[[PrecisionFStrike fucking watched]]'''. Tomorrow, there will be no shortage of volunteers, no shortage of patriots. I know you understand."
-->--[[spoiler:General Shepherd]], ''VideoGame/ModernWarfare2''

->"The gods of Olympus have abandoned me. Now there is no hope."
-->--'''Kratos''', ''VideoGame/GodOfWar''

->"The day [[StartOfDarkness I killed]] [[ParentalSubstitute The Boss]]... with my own hands... I... was already dead."
-->--'''Big Boss''', ''VideoGame/MetalGearSolid4GunsOfThePatriots''

->"I have taught you many ways to kill a mortal, Kratos; flesh that burns, bones that break. But to break a man's spirit, is to truly destroy him!"
-->--'''Ares''', ''VideoGame/GodOfWar''

->''That little boy quit trying.''\\
''He just walked away.''\\
''There were teardrops on his face.''\\
''Tell me, how would you feel?''\\
''You'd probably give up too,''\\
'[[CassandraTruth If nobody believed in you.]]''
-->-- '''Joe Nichols''', "If Nobody Believed In You"

->"Stood in firelight, sweltering. Bloodstain on chest like map of violent new continent. Felt cleansed. Felt dark planet turn under my feet and knew what cats know that makes them scream like babies in night. Looked at sky through smoke heavy with human fat and [[GodIsDead God was not there.]] The cold, suffocating dark goes on forever and we are alone. [[DesperatelyLookingForAPurposeInLife Live our lives, lacking anything better to do.]] Devise reason later. Born from oblivion; bear children, hell-bound as ourselves, go into oblivion. There is nothing else. Existence is random. Has no pattern save what we imagine after staring at it for too long. [[{{Ubermensch}} No meaning save what we choose to impose.]] This rudderless world is not shaped by vague metaphysical forces. It is not God who kills the children. Not fate that butchers them or destiny that feeds them to the dogs. [[HumansAreBastards It's us. Only us.]] Streets stank of fire. The void breathed hard on my heart, turning its illusions to ice, shattering them. [[HeWhoFightsMonsters Was reborn then, free to scrawl own design on this morally blank world.]] [[BecomingTheMask Was Rorschach.]] Does that answer your questions, Doctor?"
-->-- '''Rorschach''', ''ComicBook/{{Watchmen}}''

->"I didn't understand all the difficult words but... I did understand that all the pain I had suffered was supposed to have been yours, [[spoiler:Ganta]]. [[spoiler:Ganta]] wasn't Ace Man... but rather the cause of my suffering."
-->-- '''[[spoiler:Shiro]]''', reflecting on the day she found out that she was a replacement subject for [[spoiler:Ganta]] in ''DeadmanWonderland''.

->''"You know, apart from the fact that I'll never again experience joy in my life, I don't think ''Film/RedZoneCuba'' had any kind of negative effect on me".''
-->-- '''Crow T. Robot''', ''Series/MysteryScienceTheater3000'', "[[Recap/MysteryScienceTheater3000S06E19RedZoneCuba Red Zone Cuba]]"

->"It wasn't just the baby that died that day; something inside Sick Boy was lost and never returned. It seemed that he had no theory with which to explain a moment like this. Nor did I. Our only response was to keep on going and fuck everything: pile misery upon misery, heap it up on a spoon and dissolve it with a drop of bile, then squirt it into a stinking, prurient vein and do it all over again; keep on going, getting up, going out, robbing, stealing, fucking people over, propelling ourselves with longing towards the day that it would all go wrong, because no matter how much you stash, or how much you steal, you never have enough. No matter how often you go out and rob and fuck people over, you always need to get up and do it all over again."
-->-- '''Renton''', ''Literature/{{Trainspotting}}''

->"It's over. Everything, I did everything wrong. I want my life back. I want it back before everything got fucked up. I want to be a baby again. I want to be new. I want to be new."
-->-- '''Susan Orlean''', ''{{Adaptation}}''

->"I went into the bathroom and cried my eyes out. The whole affair had been an elaborate hoax! The two of them probably planned the whole thing just to get back at me. I was devastated, crushed out of any hope. I had nothing to live for. [[IfICantHaveYou But if I wasn't ever going to be happy again]], [[GreenEyedMonster then I would make sure that]] [[MurderTheHypotenuse they wouldn't be alive to enjoy their happiness]]."
-->-- '''Hikaru Hayama''', ''Fanfic/RevengeRoad''

->"The future...[[PutThemAllOutOfMyMisery isn't needed anymore.]]"
-->--'''[[AristocratsAreEvil Lord]] [[BigBad Darcia III]]''', ''WolfsRain''

->-"[[UnsoundEffect HOPESPLODE!]]"
-->-- ''Webcomic/{{Homestuck}}'' sums it up in a single word.

->"My name is Oerba Dia Vanille. I'm a L'Cie, from Gran Pulse, and to everyone on Cocoon, evil. Shoot me! For your son!"
-->--'''Vanille''' from ''VideoGame/FinalFantasyXIII''

->"[[OutlivingOnesOffspring My...son.]] Murdered in the heart of the Chantry, by those who held a sacred trust. What hope for this city, when we fail our own so completely?"
-->--'''Viscount Dumar''', ''VideoGame/DragonAgeII''

->"Look at it all. Why don't they just drown us as infants? Why wait? Why give us the illusion of hope?"
-->--'''First Enchanter Orsino''', ''VideoGame/DragonAgeII''

->"...the moment when someone loses all hope... [[MoralEventHorizon I really do love to watch that moment.]]"
-->--Ghetsis from ''VideoGame/PokemonBlackAndWhite''

->'''Cynder''': Fight back!...Why won't you fight back!\\
'''Spyro''': [[TearJerker ...Because you've left me nothing to fight for...]]
-->---''VideoGame/TheLegendOfSpyro: Dawn of the Dragon'' [[spoiler:After Malefor turns Spyro's girlfriend Cynder against him.]]

->''...doesn't really care about anything anymore.''
-->-- Appears in the profile of any sufficiently traumatized character in ''VideoGame/DwarfFortress''.[[note]]Player actually ''try'' [[VideoGameCrueltyPotential to make their dwarves like this]], since such dwarves are much less likely to snap under pressure[[/note]]

-> '''Someday for sure, I will bring death upon her.'''
-->--Part of '''Yuyuko's''' final entry in her diary, ''FanFic/TouhouTonari''.

-> ''[[TearJerker I'm such an idiot...]]''
-->--[[spoiler:'''Sayaka Miki''']], ''Anime/PuellaMagiMadokaMagica''

-> ''So this is a Witch. My emotions have all come back to haunt me. I can't remember anything but glimmers of light and regret. Ah, so this is my... despair.''
-->--'''[[spoiler:Homura Akemi]]''', ''Anime/PuellaMagiMadokaMagicaTheMovieRebellion''

->''It seems in the end... that I... was the greatest fool of all...''
-->--[[spoiler:'''[[WellIntentionedExtremist Alexei Dinoia]]''']], ''VideoGame/TalesOfVesperia''

-> There was a time I could see. And I ''have'' seen... boys like these - ''younger'' even - their arms torn out, their legs ripped off. But there is ''nothing'' like the sight of an amputated spirit. There is no prosthetic for that.
--> --'''Colonel Slade''', ''Film/ScentOfAWoman''

-> ''[[WithFriendsLikeThese With friends like you, who needs...]] [[TearJerker enemies...]]''
-->-- [[spoiler:'''Twilight Sparkle''', giving up her hope on saving her brainwashed friends,]] ''WesternAnimation/MyLittlePonyFriendshipIsMagic''

-> ''I... Used to be so beautiful...''
-->-- [[BrokenBird Dollface]], ''TwistedMetal''

->''I can't keep [[AngstWhatAngst pushing this down]] any deeper\\
Why do I keep trying if I can't keep her?''
-->--The beginning of "All Gummed Up Inside", sung by '''Finn''', ''WesternAnimation/AdventureTime''

->"They... They fucking killed her! Oh, [[spoiler: Xiu]]..."
-->-- ''Lynch'', ''VideoGame/KaneAndLynch: Dog Days''

->"As the Prince of Hope, I am uniquely qualified to recognize [[VerbalTic wwhen]] all hope is lost."
--> '''Eridan Ampora''', ''Webcomic/{{Homestuck}}''

->'''Linda''': You think that might be enough carrots?\\
'''Harry''': ({{beat}}) ''[[RantInducingSlight What?!]]''\\
'''Linda''': For the salad.\\
'''Harry''': [angry] ''[[DisproportionateRetribution You know you really are a negative person.]]''
--> ''BurnAfterReading'', after Harry [[spoiler:panics and murders Chad]].

-> "Dammit! Why... By letting myself be worshipped as an emissary of God, [[PhysicalGod I was meant to]] [[MessianicArchetype lead everyone...]] [[TearJerker but I can't even save one girl?]]"
-->'''[[spoiler:Kugel]]''', after [[spoiler:Linaria]] succumbs to her illness in the second OVA for ''Anime/GargantiaOnTheVerdurousPlanet''.

->''Now I can't go on, I can't even start''\\
''I got nothing left, just an empty heart''\\
''I'm a soldier, wounded so I must give up the fight''\\
''There's nothing more for me, lead me away''\\
''Or leave me lying here''
-->-- '''Bryan Adams,''' [[WesternAnimation/SpiritStallionOfTheCimarron "Remember Who You Are"]]

->''I need someone to show me the things in life that I can't find.''\\
''I can't see the things that make true happiness, I must be blind.''
-->-- '''Music/BlackSabbath''', "Paranoid"

->''Our time has passed John.''
-->-- '''[[TragicVillain Dutch Van Der Linde]]''', ''VideoGame/RedDeadRedemption''

->''I shall despair. There is no creature loves me;\\
And if I die no soul shall pity me.\\
Nay, wherefore should they? Since that I myself\\
Find in myself no pity to myself.''
-->-- ''Theatre/RichardIII''

->''I looked into the eyes of [[OmnicidalManiac the dragon]]... and despaired.''
-->-- '''Archibishop Benedictus''', ''VideoGame/WorldOfWarcraft: Cataclysm''.

->'''Jack Hawksmoor''': Is that all you can do? Make cheap, tasteless jokes when your friend dies? Have you given up? Have you given up completely?\\
'''The Doctor''': It wasn't a joke. But yes, I have given up. Sort of. Look around, Jack. Look at what's happened. Look at what's happening. Face it--no matter what I saw--we're not getting out of this in one piece. Jenny really was the spirit of the twenty-first century. If she's dead, that means [[ApocalypseHow/ClassX4 the century--and everyone living in it--dies with her]]. It's time you did what I did, Jack. Not give up. Not exactly. But accept the inevitable. If these are the last moments of the universe, do you really want to spend them whining and fighting?\\
'''Hawksmoor''': No.
-->-- ''[[ComicBook/CaptainAtom Captain Atom: Armageddon]]''

->''Sitting there on the floor, Louis put his face in his hands and began to weep. He had lost all interest in his father-in-law, in the MX missile, in permanent versus dissolving sutures, in the heat death of the universe. At that moment, Louis Creed wished he were dead.''
-->-- ''Literature/PetSematary''

->''"There's nothing left for me. No place to return to, nobody to love, and nothing to believe in..."''
-->-- '''Oersted''', ''VideoGame/LiveALive''