* The ''GabrielKnight'' adventure games are one of the earliest examples, with Tim "Wasn't cast as TheJoker ''because his audition was too frightening''" Curry as TheHero and Mark Hamill as his bumbling sidekick.
* NolanNorth, the voice of [[{{Uncharted}} Nathan Drake]] and [[Franchise/AssassinsCreed Desmond Miles]], plays [[FatBastard The Penguin]] in ''VideoGame/BatmanArkhamCity''.
** He also voices [[ThoseWackyNazis Edward]] [[MadDoctor Richtofen]] in ''VideoGame/NaziZombies''.
** He lent a vaguely nasal voice to the [[HeroicComedicSociopath hilariously insane]] Steven Heck in ''VideoGame/AlphaProtocol''.
** His role as Captain Walker in ''VideoGame/SpecOpsTheLine'' [[PlayingWithCharacterType starts out]] as a slightly more serious version of his typical role (Drake voice included) only to gradually morph into [[ShellShockedVeteran something]] [[NeverMyFault entirely]] [[HeWhoFightsMonsters different]] over the course of the game.
** He's also the voice behind ''VideoGame/SlyCooperThievesInTime'''s El Jefe.
** He also stars in ''VideoGame/TransformersWarForCybertron'' and its sequel, ''VideoGame/TransformersFallOfCybertron'', as Brawl and Bruticus, the resident Decepticon [[TheBrute brutes]]. In ''Fall of Cybertron'', it's further highlighted by his more in-type role as Cliffjumper.
** Not to mention Deadpool in ''VideoGame/MarvelVsCapcom3'', one of his highest-pitched and least serious roles he's ever had.
*** He reprises his role of Deadpool in [[VideoGame/{{Deadpool}} his own self-titled video game]], albeit with a somewhat deeper tone in general. He also does the voices in Deadpool's head, one speaking in an even higher pitch, and another deeper voice with a faux-British accent.
** David in ''VideoGame/TheLastOfUs'' is probably one of the biggest examples. What makes this so shocking is that when you meet him, he actually seems like a kind gent who has people's best interests in heart... [[spoiler: Then comes the fact that he's the leader of a bunch of raiders you killed earlier in the game. Oh, [[ImAHumanitarian he and his boys happen to be cannibals.]] And David is also implied to be a pedophile.]] Hell, people didn't even know that Nolan even voiced him till the credits, practically like KevinSpacey in ''Film/{{Se7en}}''.
** His career being a recurring member of Creator/{{Valve}} has also seen him as [[VideoGame/{{Portal2}} two hyperactive nutcases and a self-parody]], along with [[VideoGame/TeamFortress2 three absolute hams]].
** The [[StarWarsTheOldRepublic Jedi Consular]] can be playing ''to'' type on Light Side or playing ''against'' it on a Dark Side run.
** ''NarutoShippudenUltimateNinjaStorm3'' sees North playing an imposter of Madara Uchiha [[spoiler:(in reality, Obito Uchiha)]]. This goes double, as not only does he portray a [[EvilSoundsDeep a villain with a deep bass voice]], but it is, to date, the only anime-related role he has under his belt.
* Creator/RobPaulsen as Gray Fox in the remake ''[[VideoGame/MetalGearSolid Metal Gear Solid: The Twin Snakes]]''. Basically, the fact that Rob Paulsen played a very serious character (a character who is implied to be driven insane from experimentation as well as at times remorseful of his past in war, and in one source was implied to have PTSD) and do so in-character is a very sharp turn against some of his more lighthearted and comical roles.
* This was done with Naked Snake in ''VideoGame/MetalGearSolid3SnakeEater''. Motosada Mori, a martial arts expert who was hired to do the motion capture for Snake's fight scenes, was also made to do all the intimate scenes with Eve. This led to the [[ThrowItIn unintentional]] but absolutely {{Adorkable}} flinch away from her when she tried to kiss him, among other memorable scenes.
* Creator/AdamBaldwin departs from his earlier psychotic roles to voice the polite, respectable, and intelligent ([[ObfuscatingStupidity though he insists otherwise]]) Quarian marine Kal'Reegar in ''VideoGame/MassEffect2''.
** Meanwhile, respected actor Creator/MartinSheen normally plays fatherly type figures, mentors or moral leaders. Not so in the ''Franchise/MassEffect'' series where he voices [[TheChessmaster the head of the pro-human terrorist organization]], Cerberus and the universe's resident MagnificentBastard, [[KnightTemplar The Illusive Man]].
** Also, Creator/SteveBlum, who's damn near unrecognizable as Grunt or [[spoiler:the Shadow Broker]].
* [[Series/StarTrekVoyager Kate]] [[TheCaptain Mulgrew]] as [[Franchise/DragonAge Flemeth]].
** From ''VideoGame/DragonAgeOrigins'', the first game, we have Creator/TimCurry as Arl Rendon Howe. While Howe is a villain, Curry is usually known for playing the likable EvilIsCool and EvilIsHammy type villains. Arl Howe, on the other hand, is incredibly subtle and downplayed and it ends up with Howe being one of the most despicable villains he's ever played.
* Creator/MauriceLaMarche voices Calendar Man, a murderer who commits his crimes on certain holidays, in ''VideoGame/BatmanArkhamCity''. Normally, he plays comedic roles.
** He also plays [[AntiVillain Mr.]] [[WoobieDestroyerOfWorlds Freeze]] in the same game, a character who is definitely not a comedic role.
* Creator/SpikeSpencer plays Arakune in ''VideoGame/BlazBlue''. He normally plays small and cowardly boys. Instead, here he plays a psychotic blob monster with a [[EvilSoundsDeep much deeper voice]] than what he's used to.
** In ''VideoGame/FireEmblemAwakening'', he voices Excellus, a [[SissyVillain Sissy]] SmugSnake [[DudeLooksLikeALady who Looks Like a Lady]].
** ''LeagueOfLegends'' has Spencer voicing Wukong, a [[TricksterArchetype tricky]] [[BloodKnight fight-happy]] [[EverythingsBetterWithMonkeys monkey]].
* ''VideoGame/BlazBlue'' is one huge testimony to Creator/TetsuyaKakihara Playing Against Type. The man who was known for his young, sometimes naive, but undeniably heroic roles like [[Anime/TengenToppaGurrenLagann Simon]] or [[VideoGame/TalesOfHearts Shing Meteoryte]] plays the role of Jin Kisaragi, arrogant {{Jerkass}} extraordinaire, practically a KnightInShiningArmor GoneHorriblyWrong. If that wasn't enough, [[spoiler: Tetsuya Kakihara also voices Jin's future self, Hakumen, who speaks in a deep and slightly mechanical voice, and a ''booming'' LargeHam at that!]]
* Creator/CharlieAdler plays Super-Skrull in ''VideoGame/MarvelVsCapcom3''. While he's played Super-Skrull in some of the villain's animated appearances, he's way better known for playing small FunnyAnimal characters than intergalactic warlords.
* ChristopherLee voicing DIZ in ''VideoGame/KingdomHeartsII'' qualifies as a PlayingAgainstType, as the guy usually plays villainous roles, and yet in this game, he's actually a hero. [[AntiHero Kind of.]]
* CharlesMartinet, who is best known for playing [[Franchise/SuperMarioBros Mario]], plays TheMentor Paarthurnax in ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'', one of the most [[TheAtoner complex]] and [[CainAndAbel compelling]] characters in the history of the Elder Scrolls, not to mention someone who talks a lot and is a BadassBaritone, that alone is a huge contrast to Mario.
** Before Paarthurnax, Martinet also played the villainous Gouji Rokkaku in ''VideoGame/JetSetRadio Future''.
** And before ''that'', he played the antagonistic, creepy, and androgynous Homunculus in ''VideoGame/ShadowOfDestiny''.
* Creator/JoshKeaton is well known as the voice of many a teenaged hero, such as SpiderMan. Then along comes ''VideoGame/NoMoreHeroes'', where he lends his voice to the AxCrazy superhero-themed assassin Destroyman.
** He also plays a young Revolver Ocelot in Metal Gear Solid 3: Snake Eater. There he's a gunslinger with a chip on his soldier, and a younger version of one of the main antagonists of the series.
** Also from ''NoMoreHeroes'', we have Travis Touchdown, an American {{Otaku}} BloodKnight played by Creator/RobinAtkinDownes, who pulls an amazing FakeAmerican accent where his most famous roles have him as either a {{Badass}} Brit or a [[VideoGame/TeamFortress2 mad German scientist]].
* Creator/AliHillis voices mainly stern, serious no-nonsense characters such as [[VideoGame/FinalFantasyXIII Lightning Farron]], [[Franchise/MassEffect Liara T'Soni]] and [[VideoGame/NinjaGaiden Mizuki Mccloud]]. Then there's [[VideoGame/KidIcarusUprising Palutena]], who is anything but.
** From the same game, we have Creator/HyndenWalch, who typically portrays sweet and naive girls like [[WesternAnimation/TeenTitans Starfire]], [[Anime/TengenToppaGurrenLagann Nia]], and [[Anime/LuckyStar Yutaka Kobayakawa]]. Here, she plays Viridi, a snarky, petty, vengeful god of nature.
* Aaron Spann is well known for voicing good boys like [[VideoGame/DissidiaFinalFantasy Onion Knight]]. Then there comes [[VideoGame/TheWorldEndsWithYou Joshua]], where he lends his voice to an [[SmallNameBigEgo arrogant]] [[InsufferableGenius genius]] [[SmugSmiler smiler]].
* Danny Jacobs is probably best known for being a PoorMansSubstitute of Creator/SachaBaronCohen as [[Film/EpicMovie Borat]] and [[WesternAnimation/ThePenguinsOfMadagascar King Julien]]. In ''VideoGame/BatmanArkhamAsylum'' and its sequel, ''VideoGame/BatmanArkhamCity'', he lends his voice to the creepy, knife-wielding psychopath Victor Zsasz.
* Creator/LiamOBrien is normally known for playing either outright villainous or [[AntiHero Anti-Heroic]] roles. In ''VideoGame/FireEmblemAwakening'', he voices a purely-heroic, not-angsty-in-the-slightest ChivalrousPervert who's [[ShrinkingViolet secretly a bit shy.]]
** And a far cry from the brooding, contemplative characters he tends to voice, he's Asura in ''VideoGame/AsurasWrath''. Still brooding and contemplative to an extent...but with a lot more HotBlooded screaming.
** He also played troubled NiceGuy and hero Akihiko Sanada in ''{{VideoGame/Persona 3}}''.
* When one thinks Creator/ChristopherSabat, one thinks BadassBaritone ([[Anime/DragonBallZ Vegeta]], [[Manga/FullmetalAlchemist Alex Louis Armstrong]], [[Anime/PantyAndStockingWithGarterbelt Garterbelt]], [[VideoGame/DissidiaFinalFantasy Garland]]). ''VideoGame/{{Borderlands 2}}'' sees Sabat as Innuendobot 5000, a Hyperion robot reprogrammed by Moxxi to only speak in {{Double Entendre}}s in a strangely high-pitched voice.
* Creator/BrycePapenbrook is best well-known for his KidHero, NiceGuy, and {{Keet}} roles like [[LightNovel/SwordArtOnline Kirito]], [[VideoGame/FinalFantasyIX Zidane]], [[VideoGame/FireEmblemAwakening Henry]], [[LightNovel/{{Durarara}} Masaomi Kida]], [[Manga/BlueExorcist Rin Okumura]], [[VideoGame/TalesOfGraces Asbel]], [[VideoGame/BravelyDefault Tiz]], and [[VisualNovel/DanganRonpa Makoto Naegi]]. In ''VideoGame/ShinMegamiTenseiIV'', he voices Issachar, a friend of the main character who has an upbeat attitude until he got rejected by the Samurai's Gauntlet. [[spoiler:Then later on, he transforms into a demon and the boss fight against Issachar is memorably [[NightmareFuel/ShinMegamiTenseiIV one of his creepiest roles]]. At least in the case of [[VideoGame/FireEmblemAwakening Henry]], the creepy parts of him are usually PlayedForLaughs.]]
* Previously, Terrence C. Carson was best known as the smooth-talking stockbroker and [[TheCasanova ladies man]] Kyle on the sitcom ''LivingSingle''. Nowadays, you'd probably know him better as the voice of [[GodofWar Kratos]], the vicious, murdering Spartan who [[RageAgainstTheHeavens razed Olympus]] and [[NoIndoorVoice has no time for smooth talk]]. In spite of all this, Kratos is [[MemeticSexGod quite the ladies man himself]]!
* Meta: From the man who brought you the adaption of ''[[Literature/ThePilgrimsProgress The Pilgrim's Progress]]'' brings you... ''[[VideoGame/FiveNightsAtFreddys Five Nights at Freddy's!]]''[[note]]and its sequel, too[[/note]]
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