* ''VideoGame/AlteredBeast'' includes a stage wherepower-ups transform the player into a weretiger, which provides extra strength and firepower.
* ''VideoGame/AtelierIris'' features werecats as random monsters.
* In ''Videogame/BarkleyShutUpAndJamGaiden'', during an optional path to Liberty Island, Balthios James is revealed to be a Wereduergar who transforms into a rampaging [[OurDwarvesAreAllTheSame Duergar]] (dark-skinned dwarves) every Columbus Day.
* In ''VideoGame/{{Bayonetta}}'', the main character has the ability to transform into a black panther at will, granting her cheetah-like speed. Likewise, the character Jeanne (a fellow witch in the game) can transform into a red lynx.
* The main gimmick of ''VideoGame/BloodyRoar'' is that every character is some sort of werebeast. There's a weretiger, werebear, werelion, wererabbit, werefox, werecat, wereboar, weremole, werebat, werechameleon...
* ''VideoGame/{{Borderlands}}'' has Were-Skags in the first DLC[[note]]Skags are pretty wolf-like, coming in varieties like "Pup" and "Alpha", but possess armor plating and heads like Venus fly traps, which open vertically.[[/note]]
* In ''VideoGame/BreathOfFireIII'', one of the main characters, Rei, is a weretiger.
* While ''Franchise/{{Castlevania}}'' is usually content with werewolves, some installments give other animals a chance to shine (and rip the player apart):
** ''VideoGame/CastlevaniaCircleOfTheMoon'' features [[BearsAreBadNews werebears]], werejaguars, weretigers, and more.
** ''VideoGame/CastlevaniaAriaOfSorrow'' features a couple of these also.
** ''VideoGame/{{Castlevania 64}}'' devotes a tower to battling a variety of them, and its prequel ''Legacy of Darkness'' gives us Ortega, a werelion who receives enough power from Dracula to become a werechimera.
* The Druid of ''VideoGame/{{Diablo}} II'' can turn into a [[MightyGlacier Werebear]] or [[FragileSpeedster Werewolf]].
* ''VideoGame/DragonAgeOrigins'' a variety of werebeasts. Most werebeasts are actually humans or animals possessed by demons from [[SpiritWorld the Fade]] and subsequently mutated.
* In the DLC for ''VideoGame/DungeonsOfDredmor'', there's a skill that allows the player to become a Werediggle. Diggles are the game's MascotMook, rubbery birdlike things with drills on their beaks.
* ''VideoGame/DwarfFortress'' includes were-everythings[[note]]Well every non-sapient mammal and reptile in the game[[/note]], including weresheep, werekoalas, and weregoats. To be specific, during the generation of a world's history, peasants will sometimes profane a god's temple. The god of the temple will then {{curse}} them into turning into a randomly chosen creature when the moon is full. The curse's victim then runs away from their town and finds a hole in the ground out in the wilderness to live in. Sometimes when the full moon comes out they'll go back to the town and bite someone to make new were-whatevers, who will in turn flee into the wilderness and inhabit their own hole-in-the-ground. If you let world generation go on for long enough the wilderness around a town with a temple can become absolutely infested with were-giraffes/zebras/platypi.
* ''Franchise/TheElderScrolls'' universe features a variety of therianthropic creatures, including werewolves, wereboars, werelions, werecrocodiles, werebears werevultures and even [[UnreliableNarrator possibly]] weresharks. Apart from werewolves, werebears and wereboars, all of these were only mentioned in the in-universe book "On Lycanthropy" in ''[[VideoGame/TheElderScrollsIIDaggerfall Daggerfall]]''.
** Werebears finally make an appearance in ''Dragonborn'', the second DLC for ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]''.
** While the information in ''On Lycanthropy'' is obviously outdated, seeing as what it stated was the dominant strain in the province of Skyrim is ''completely'' absent from the game of ''Skyrim'' (up until the ''Dragonborn'' DLC, which doesn't even take place in Skyrim, and in fact had been visited and confirmed as werebear-free in a previous game), one thing it says is consistently indicated by the games: werewolves are the most ubiquitous, common form of lycanthropy in Tamriel, and that is why it is traditionally called lycanthropy even if it only strictly should refer to werewolves.
* While not called werebeasts or werecreatures, ''VideoGame/FireEmblemTellius'', has Laguz: a race of people who can shift from human-like forms into animal forms. When in human form, they still have certain animal-like physical traits, such as tails, wings, ears, and colored stripes on their faces. Varieties include cat, tiger, lion, [[WereWolf wolf]], hawk, raven, heron, and [[OurDragonsAreDifferent dragon]].
** ''VideoGame/FireEmblemAwakening'' features their successors, the taguel--essentially giant were''rabbits''.
* Pictured on the main OurWerebeastsAreDifferent page are the animal forms of the Norn race from ''GuildWars2'', they have a pantheon of animal spirits that they worship, but venerate four above all the rest for directly aiding them in an exodus from their homeland, besides the bear and wolf (they lack boar in-game, interestingly) pictured above, there's also the raven and snow leopard forms.
* In ''VideoGame/TheLegendOfZeldaALinkToThePast'': When people enter the Dark World, they turn into an animal (real or fantasy) that reflects their personality. Link becomes a pink bunny rabbit but keeps his trademark tunic.
** Similarly in ''VideoGame/TheLegendOfZeldaTwilightPrincess'', Link turns into a wolf when exposed to Twilight, rather than a ghost like everyone else, because of the shielding effects of the Triforce of Courage.
* In ''[[TheMuppets Muppet Monster Adventure]]'' Fozzie Bear is turned into a Wocka Wocka Werebear.
* ''VideoGame/NetHack'' has wererats and werejackals in addition to the usual werewolves. All three types can infect you with their flavor of lycanthropy.
* ''VideoGame/OgreBattle'' features weretigers as hidden characters who can be recruited.
* ''VideoGame/{{Quest 64}}'' has the werehare and werecat.
* In ''VideoGame/SonicUnleashed'', Franchise/SonicTheHedgehog can turn into Sonic the ''Werehog'' at night. During his transformation, Sonic is a bigger, furrier, and werewolfish version of himself with huge stretchy arms. He's nowhere near as fast as he is in his normal form, but he is ''much'' stronger.
** Unlike most examples of lycanthropy, or even the other possessed people in the game, he's able to fully control himself. Why? Could it be that annoying magical sidekick on his shoulder protecting him? Actually no, it's because Sonic the Hedgehog is ''[[CanonSue just that awesome]]''.
* Keine Kamishirasawa from ''VideoGame/{{Touhou}}'' is a were-[[http://en.wikipedia.org/wiki/Bai_Ze hakutaku]], a mythological beast that appears to wise and just rulers to dispense advice. Her transformation is limited to [[LittleBitBeastly a hair of pointy horns and a bushy tail]], and a change in hair (and dress) colour, from blue to green. It's also said she wasn't born a were-hakutaku, but that it's acquired.
* ''VideoGame/VampireTheMasqueradeBloodlines'' includes werebatlike creatures and weresharks which come as a GiantSpaceFleaFromNowhere event.