* ''VideoGame/AlteredBeast'' includes a stage wherepower-ups transform the player into a weretiger, which provides extra strength and firepower.
* ''VideoGame/AtelierIris'' features werecats as random monsters.
* The ''Videogame/BaldursGate'' expansion pack 'Tales of the Sword Coast' has the PC and their party shipwrecked on an island inhabited by Werewolves and Wolfweres, in a constant struggle with each other.
* In ''Videogame/BarkleyShutUpAndJamGaiden'', during an optional path to Liberty Island, Balthios James is revealed to be a Wereduergar who transforms into a rampaging [[OurDwarvesAreAllTheSame Duergar]] (dark-skinned dwarves) every Columbus Day.
* In ''VideoGame/{{Bayonetta}}'', the main character has the ability to transform into a black panther at will, granting her cheetah-like speed. Likewise, the character Jeanne (a fellow witch in the game) can transform into a red lynx.
* ''Videogame/{{Bloodborne}}'' has them as the result of a more Zombie-esque plague, which gradually transforms its victims from mere humans, to slightly altered UncannyValley dwellers, to gradually-[[BuffySpeak wolfier]] mutants who gradually acquire nonhuman features, followed by others that aren't even wolflike anymore. And it only gets worse from there; the most advanced stages, usually affecting [[AndThenJohnWasAZombie hunters of these same beasts]], include things like electrified zombie werewolves and gigantic, [[HellIsThatNoise screaming]] monsters that could devour whole crowds in one bite.
* The main gimmick of ''VideoGame/BloodyRoar'' is that every character is some sort of werebeast. There's a weretiger, werebear, werelion, wererabbit, werefox, werecat, wereboar, weremole, werebat, werechameleon...
* ''VideoGame/{{Borderlands}}'' has Were-Skags in the first DLC[[note]]Skags are pretty wolf-like, coming in varieties like "Pup" and "Alpha", but possess armor plating and heads like Venus fly traps, which open vertically.[[/note]]
* In ''VideoGame/BreathOfFireIII'', one of the main characters, Rei, is a weretiger.
* In ''VideoGame/CaptainMorganeAndTheGoldenTurtle'', Father Jérôme of Crab Island is worried about werecrabs, though we see no evidence they actually exist.
* While ''Franchise/{{Castlevania}}'' is usually content with werewolves, some installments give other animals a chance to shine (and rip the player apart):
** ''VideoGame/CastlevaniaCircleOfTheMoon'' features [[BearsAreBadNews werebears]], werejaguars, weretigers, and more.
** ''VideoGame/CastlevaniaAriaOfSorrow'' features a couple of these also.
** ''VideoGame/{{Castlevania 64}}'' devotes a tower to battling a variety of them, and its prequel ''[[VideoGame/CastlevaniaLegacyOfDarkness Legacy of Darkness]]'' gives us Ortega, a werelion who receives enough power from Dracula to become a werechimera.
* The Druid of ''VideoGame/DiabloII'' can turn into a [[MightyGlacier Werebear]] or [[FragileSpeedster Werewolf]].
* ''VideoGame/DragonAgeOrigins'' a variety of werebeasts. Most werebeasts are actually humans or animals possessed by demons from [[SpiritWorld the Fade]] and subsequently mutated.
* In the DLC for ''VideoGame/DungeonsOfDredmor'', there's a skill that allows the player to become a Werediggle. Diggles are the game's MascotMook, rubbery birdlike things with drills on their beaks.
* ''VideoGame/DwarfFortress'' includes were-everythings[[note]]Well every non-sapient mammal and reptile in the game[[/note]], including weresheep, werekoalas, and weregoats. To be specific, during the generation of a world's history, peasants will sometimes profane a god's temple. The god of the temple will then {{curse}} them into turning into a randomly chosen creature when the moon is full. The curse's victim then runs away from their town and finds a hole in the ground out in the wilderness to live in. Sometimes when the full moon comes out they'll go back to the town and bite someone to make new were-whatevers, who will in turn flee into the wilderness and inhabit their own hole-in-the-ground. If you let world generation go on for long enough the wilderness around a town with a temple can become absolutely infested with were-giraffes/zebras/platypi.
* ''Franchise/TheElderScrolls'':
** The series and background lore contains a variety of lycanthropic[[note]]Yes, this should ''technically'' only refer to werewolves, as "lycan" comes from the Greek word for "wolf", but is is frequently used to refer to ''all'' were-creatures creatures in-universe[[/note]] creatures. [[OurWerewolvesAreDifferent Werewolves]] are the most ubiquitous throughout Tamriel and have appeared in the most games (including ''[[VideoGame/TheElderScrollsIIDaggerfall Daggerfall]]'', ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]'''s ''Bloodmoon'' expansion, ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'', and ''[[VideoGame/TheElderScrollsOnline Online]]''), each of which offers the option of the PlayerCharacter becoming a werewolf. Wereboars also appear in ''Daggerfall'', with the the PC again having the option of becoming one. Werebears are noted throughout the lore and finally make an appearance in ''Skyrim''[='s=] ''Dragonborn'' expansion, but the PC cannot become one. ''Online'' adds werebats, but once again, the PC cannot become one. The series' lore also mentions werelions, werecrocodiles, werevultures and even [[UnreliableNarrator possibly]] weresharks, but these have so far not appeared in the series.
** In terms of the details of the condition, like [[OurVampiresAreDifferent Vampirism]], Lycanthropy is [[ViralTransformation technically a disease]] and can be spread through any wound inflicted by an infected individual. It is easily cured within the first few days of being contracted, but once it fully progresses, it becomes far more difficult to cure. There are also rare instances of the disease being hereditary. The exact effects of the disease vary greatly between individuals and regions. The most common effect is an [[InvoluntaryShapeshifter involuntary transformation]] into a humanoid beast form at night, with the frequency of the transformation varying from nightly to monthly. Other individuals have the ability to [[SuperMode transform voluntarily]]. For those who transform involuntarily, they must commonly [[HorrorHunger kill a sentient being]] during the night or risk returning to their mortal form in an extremely weakened state. Lycanthropy is a creation of Hircine, the [[OurGodsAreDifferent Daedric Prince]] of [[TheWildHunt the Hunt]], who bestows it as a blessing. He considers were-creatures to be the epitome of [[HuntingTheMostDangerousGame the nature of a hunt]]. During the night, they are vicious beasts who hunt their prey. During the day, they [[TheHunterBecomesTheHunted become the hunted]] to the very same prey. Were-creatures also have a spiritual connection to Hircine, as he [[YourSoulIsMine claims their souls]] upon death to forever serve in his realm of Oblivion, known as the Hunting Grounds. Additional details are available on the ''Elder Scrolls'' "[[Characters/TheElderScrollsOtherRaces Other Races]]" sub-page.
* ''Franchise/FireEmblem'':
** While not called werebeasts or werecreatures, ''VideoGame/FireEmblemTellius'' has Laguz: a race of people who can shift from human-like forms into animal forms. When in human form, they still have certain animal-like physical traits, such as tails, wings, ears, and colored stripes on their faces. Varieties include cat, tiger, lion, [[WereWolf wolf]], hawk, raven, heron, and [[OurDragonsAreDifferent dragon]].
** ''VideoGame/FireEmblemAwakening'' features the Taguel--essentially giant were''rabbits'' [[SuspiciouslySimilarSubstitute who are very similar to the Laguz]]; Panne mentions in her support with the Avatar that there used to be other varieties of Taguel before they were all but wiped out.
** In ''VideoGame/FireEmblemFates'', the nation of Nohr has the Wolfskin, who can transform into giant ogre-like werewolves, while the {{Kitsune}} of Hoshido are well, [[ExactlyWhatItSaysOnTheTin Kitsune]].
* The second ''VideoGame/GloryOfHeracles'' game has a were-''[[spoiler:gryphon]]''.
* Pictured on the main OurWerebeastsAreDifferent page are the animal forms of the Norn race from ''VideoGame/GuildWars2'', they have a pantheon of animal spirits that they worship, but venerate four above all the rest for directly aiding them in an exodus from their homeland, besides the bear and wolf (they lack boar in-game, interestingly) pictured above, there's also the raven and snow leopard forms.
* In ''VideoGame/TheLegendOfZeldaALinkToThePast'': When people enter the Dark World, they turn into an animal (real or fantasy) that reflects their personality. Link becomes a pink bunny rabbit but keeps his trademark tunic.
** Similarly in ''VideoGame/TheLegendOfZeldaTwilightPrincess'', Link turns into a wolf when exposed to Twilight, rather than a ghost like everyone else, because of the shielding effects of the Triforce of Courage.
* In ''[[Franchise/TheMuppets Muppet Monster Adventure]]'' Fozzie Bear is turned into a Wocka Wocka Werebear.
* ''VideoGame/NetHack'' has wererats and werejackals in addition to the usual werewolves. All three types can infect you with their flavor of lycanthropy. If you happen to have [[VoluntaryShapeshifting polymorph control]], you can choose not to change forms when the time comes.
* ''VideoGame/OgreBattle'' features weretigers as hidden characters who can be recruited.
* ''VideoGame/{{Quest 64}}'' has the werehare and werecat.
* In ''VideoGame/SonicUnleashed'', Franchise/SonicTheHedgehog can turn into Sonic the ''Werehog'' at night. During his transformation, Sonic is a bigger, furrier, and werewolfish version of himself with huge stretchy arms. He's nowhere near as fast as he is in his normal form, but he is ''much'' stronger.
** Unlike most examples of lycanthropy, or even the other possessed people in the game, he's able to fully control himself. Why? Could it be that annoying magical sidekick on his shoulder protecting him? Actually no, it's because Sonic the Hedgehog is ''[[CanonSue just that awesome]]''.
* Keine Kamishirasawa from ''VideoGame/{{Touhou}}'' is a were-[[http://en.wikipedia.org/wiki/Bai_Ze hakutaku]], a mythological beast that appears to wise and just rulers to dispense advice. Her transformation is limited to [[LittleBitBeastly a pair of pointy horns, a bushy tail]], and a change in hair (and dress) color, from blue to green. That's because she wasn't born a were-hakutaku, but acquired that trait.
** Kagerou Imaizumi is a were-Honshu wolf (an extinct subspecies of the grey wolf) who [[LittleBitBeastly takes on characteristics of a wolf]] during the full moon, and can turn into an actual wolf during her spell cards. She's a calm, composed person, and remains so even when transformed, although she's somewhat insecure about how hairy she gets when she transforms.
* ''VideoGame/VampireTheMasqueradeBloodlines'' includes werebatlike creatures and weresharks which come as a GiantSpaceFleaFromNowhere event.