Spoilers below. You've been warned.
* [[ExactlyWhatItSaysOnTheTin The End]]. It begins with Castle in Sing Sing after a [[TheEndOfTheWorldAsWeKnowIt horrific nuclear war]]. A year later Frank and another prisoner escape, heading to NewYorkCity through the irradiated wasteland. Past burning skies, assisted suicides and Terminator style mountains of skulls, we learn that the other prisoners were cannibalistic and the nukes were detonated in mid air to kill more people. As they reach New York, Frank collapses and wakes up in the care of [[AncientConspiracy the Coven]], who were responsible for what happened. He escapes and kills everyone, knowingly condemning the human race to extinction. The comic ends with Castle burning from radiation and fire as he walks to Central Park to, in his mind, be with his family.
* Also by GarthEnnis, ThePunisher arc ''Up Is Down and Black Is White'', has Frank [[BerserkButton driven off the deep end]] by a [[AxCrazy vicious mob boss]]. After a night of him going ''ballistic'' on the New York underworld, the next issue opens on Frank sitting silently on a Police car...''surrounded'' by the corpses of civilians, hoods and cops. He starts to hear a ghostly voice calling to him...
-->"Frank...Frank... ''[he sees the silhouette of a [[DeathByOriginStory young woman and two children]]]'' ...we're ''still dead''.Frank." ''[[[CatapultNightmare Frank jerks awake]]]''
* ''Every. Single. Thing.'' About "The Slavers" arc. From what Viorca tells Frank about her baby to what the horrific things the titular slavers did to their prisoners to - most disturbing of all - the apathetic response to what happened, it is ''all'' horrifying and disturbing. This is not to mention the [[PayEvilUntoEvil extreme lengths Frank Castle goes to]] in order to destroy the slavers in question. And, as far as the human-trafficking goes, it's all TruthInTelevision.
* ''Punisher POV'' towards the end, as we find out that the monster is a mutated baby.
* MAX Bulleye's attempts to get inside Frank's head.
** In one attempt to get into the mind of Frank, Bullseye [[spoiler: kidnapped a woman along with her son and daughter after killing her husband and tried to reenact that fateful day in Central Park.]] It didn't work. So what does Bullseye do? [[spoiler: He tried again with ''3 more different families'', all with the same results.]]
* Frank Castle's own death during the ''MarvelDarkReign'' also counts. There are few sequences in the Marvel universe that so effectively and blatantly present the risks of BullyingTheDragon, as Punisher's stubbornness and arsenal are pitted against the [[HealingFactor regenerating]] Daken, who proves just how useless they are. Daken starts by shooting him and blowing him up with grenades, seemingly just for kicks. Then the mutant closes to hand to hand range, where he pummels Punisher mercilessly, breaks his leg, slices his throat open, hacks off a limb, and, finally bored of it all, cuts him into pieces with the ease of an industrial meat slicer.
* The Valley Forge Massacre. The N.V.A. launched an assault on Firebase Valley Forge where Frank was the top dog. Due to bad weather and other problems they couldn't receive reinforcements. After the battle ended and the smoke cleared 700 men were dead, including 200 US troops. Frank was the only survivor; he was found still standing, surrounded by twenty enemy soldiers with their heads smashed in, holding a broken rifle and riddled with bullet holes. The story arc ''Valley Forge, Valley Forge'' has typed interludes that are excerpts from the book of the brother of one of the men who died, featuring interviews with those involved (the sister of his brother's friend, the man on the radio and one of the men who first arrived at the aftermath). All three of them combined paint a picture of the events surrounding the massacre and its effect on Frank Castle, and its a very scary picture. The massacre itself is detailed in the ''Born'' miniseries and reveals why Frank survived: he made a deal with either The Devil or Death.