* The fragments of the Tablet affect each person heavily, and the glowing eyes really don't help make you comfortable.
* Noir Vulture, a vengeful cannibal who killed and ate Uncle Ben, threatens his henchmen with death by similar fates if they fail him, and takes bites at the screen with unpleasant close-ups during his [[PressXToNotDie quick-time events]].
* Carnage is about as bad, take the following facts: The local military made a stupid decision and their base was screwed over, everyone Carnage killed reanimated as zombies, [[FridgeHorror and there's a very likely chance that if Spider-Man failed, the world would have been screwed]] or the damage that would be impossible to completely fix.
* Goblin's stage. It's like something out of of a Creator/StephenKing novel, not helped at all by the rather grisly ringmaster and his band of vengeful circus freaks.