[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/1973559_atrocity.jpg]]
[[caption-width-right:350: And you thought [[VideoGame/SpiderMan2000 Monster Ock]] wasn't bad enough.]]

* The opening sequence, after Sloan goes back in time, we're treated to watching all of 2099 shift. Sure, it was no paradise future to begin with, but it's even worse when the sky darkens, likely due to pollution, every building seems to be overtaken by Alchemax, and one sign says, "Start your career as a human test subject." Alchemax effectively took Manhattan in the most literal sense. Just as well, watching the Art/StatueOfLiberty shift into a nightmarish parody of itself, holding a sword and shield in place of a torch and book and featuring a hideous snarl on its face? Creepy as hell.
** And this extends to the effects on the past, turning the Daily Bugle into the main Alchemax building, turning Peter Parker into their employee and altering his memories. No wonder the poor superhero was confused when Miguel told him what we are familiar with.
* Atrocity (Pictured), a HumanoidAbomination [[FusionDance composed]] of [[spoiler:Anti-Venom, Doctor Octopus, and Walker Sloan, the game's original BigBad]]. It's '''even bigger''' than Monster Ock, can teleport as well as summon CombatTentacles from ''outside of reality'' to attack you, [[ArsonMurderAndJaywalking and it's really ugly, too.]]
* Anti-Venom qualifies to an extent as well.
* Atrocity's terrifying level includes having to lure the creature into a gas chamber and hit it with knockout gas in order to draw tissue samples from its body. Never knowing if or when Atrocity will wake up from its sedation helps create a pants-crapping atmosphere of tension.
* It's quite unsettling to see the CEO's archive room right after TheReveal. [[spoiler:It's a shrine dedicated to Peter Parker's past problems and failures, showing just ''how'' messed up 2099!Peter Parker really is]].
* The encounter with Black Cat. She's clearly in the midst of some serious SanitySlippage, and [[spoiler: all that's been done to her has been at the hands of Peter himself.]]
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