* ''WesternAnimation/TheGrimAdventuresOfBillyAndMandy'':
** Many of the injuries, such as when Pud'n [[EyeScream gets an eye full of cactus and pulls it off, revealing a hideous, skinless red eye]].
** Or Billy's nose popping.
** Or when the closing iris closes on Billy's head and a bunch of blood and snot sprays from his nose and his eye pops out.
** Or when Billy and Mandy force Grim to resurrect the school mascot cats. That, in itself, is pretty bad, but when Billy asks one of the cats to scratch his back...his skin and muscle get shredded by the splintered claws of the undead cat, and his spinal column pokes out.
* ''WesternAnimation/{{Futurama}}'':
** "The Sting" had a nauseating shock when Zoidberg looks down at Fry's corpse in the coffin, and you see that not only is the base of the stinger that killed him still sticking out of his belly, but the point of the stinger, which is sticking out of his ''back'', is balanced on the lining of the coffin, and Fry's body is lodged in one position ''half-way'' down the stinger, so his whole back is arched upwards, (and stiff with rigor mortis) not even close to resting on the lining. The humorously executed shot that reveals this just adds to the shock value. And insult is added to injury when the coffin is closed, and a horrible snapping sound is heard. And just to make it worse, this was not a humorous death at all. ''Futurama'' was quite happy to wallow in black humor. [[spoiler: Fortunately it turned out that Fry's death was Leela's coma hallucination.]]
** When Leela switches bodies with Professor Farnsworth in “The Prisoner of Benda”, she accuses Fry of only caring about her because of her appearance. In an effort to prove that Leela wouldn't love him if he were ugly, Fry switches bodies with Zoidberg. This leads to them performing various disgusting acts on their date that night in an effort to one-up each other, and it eventually culminates in the two of them having sex with each other that night while they're still in the Professor and Zoidberg's bodies!
*** This might actually have been worse if Fry had [[IncestIsRelative stayed in his own body]].
** Bender in the first part of "Anthology of Interest II" ends up a grotesque, naked, thousand-pound blob after being turned human and going on a week-long binge. That's not the really bad part. The really bad part is when he pulls a greasy, dripping sandwich out from between his fat rolls and offers it to the horrified onlookers.
** "Murder on the Planet Express" contains a scene where [[spoiler:Leela unknowingly eats Fry's kidney.]]
* In only 2 episodes of {{Mucha Lucha}} there was a GrossUpCloseUp of The Flea's rotten teeth.
** One episode began with The Flea eating inedible things, to which Buena Girl tells him, "You shouldn't be eating that! It's bad for your digestive system!" We then cut to a sickening shot of The Flea's insides as we see him eating, with ''everything'' in his body visible, and it's animated and illustrated as disturbingly and disgustingly as possible. Words cannot explain.
* ''WesternAnimation/InvaderZim'':
** Episodes "Rise of the Zitboy" and "Lice" are this when it's not being hilarious.
** There's also the bit in "Walk of Doom" when Zim looks straight at the sun and [[EyeScream his eyes burn and bubble]].
** "Dark Harvest". It's not even the organ theft itself, or the sight of swollen, organ-filled Zim, but the nurse's room receptionist getting her brain replaced with a cola can and spewing out soda fizz every time she tries to speak.
** The clincher for that episode was when Zim SPITS UP A SMALL INTESTINE AND THEN SLURPS IT BACK UP.
** Bloaty's. ''Pizza''. ''HOG''. [[http://cfs4.flvs.daum.net/files/57/12/17/26/19135881/thumb.jpg Just look at him!]] And the guy that's inside the suit...just [[http://www.youtube.com/watch?v=DYTITPo-iks bleeeeuurck.]]
* ''WesternAnimation/ThePebbleAndThePenguin'': The sequence for the song "Good Ship Misery" involves penguins dumping disgusting-looking slop all over each other, breaking out into spots, and ''simultaneously vomiting over each other''. EW.

* Despite extensive use of rats, ''WesternAnimation/{{Ratatouille}}'' has only one nausea-inducing scene: lots of sewer rats invading a pantry and climbing up the shelves.
* ''WesternAnimation/TheSimpsons'':
** Homer's eyes crusting over after Lasik surgery (though it becomes Nausea Fuel [[NightmareRetardant Retardant]] when the next scene with Homer {[[ContinuityNod still blind from the scabs over his eyes]]} being driven to the liquor store by Kearney and his GangOfBullies for Jack Daniels and cigarettes) and the wound from his ACL injury growing over Ralph's hand ("It knows you're afraid!") being among the worst.
** When Willie strangles Homer with a pipe, and his eyeball pops halfway out of his socket (a la Mr. [=DeMartino=] from ''WesternAnimation/{{Daria}}'') resulted in an immediate gag reflex.
** In "Stop, or My Dog will Shoot!", Bart buys the snake where he asks for "five feet" and the pet store guy measures out the proper amount from a snake roll and cuts it off with a paper slicer. Simultaneous NauseaFuel and FridgeLogic (if that's how it's done, how does the next snake have a head???).
** Season 12's "Trilogy of Error" (a.k.a the RashomonStyle episode showing Bart's, Lisa's, and Homer's points of view on Science Fair Day at school) where Marge cuts Homer's thumb off, and blood keeps squirting out of the nub and Homer is trying to rush to the hospital and his digit keeps fading in color... It made him unwell.
** The very end segment of "Treehouse of Horror V" is rather nauseating. The whole family get turned inside out by a fog (after Bart wakes up from his dream of being cannibalized by the staff at Springfield Elementary) and begans singing and dancing about it. To add insult to injury, Santa's Little Helper comes out and grabs Bart by his intestines carrying him off. [[{{Squick}} ICK]].
** "The Bob Next Door". Sideshow Bob switches identies with his cellmate. Their faces come undone at least 4 times, showing off the muscles underneath!
** [[CargoShip Homer's "affair" with a large hero sandwich]] as seen in "Dial N for Nerder." So bad, the host of the Cheaters {{expy}} show said, "I never thought I'd say this, but turn the camera off!"
** Itchy and Scratchy.
** There was a short bit where Homer had gotten into a fight with a badger, and was left with a window into his soul. OK, not his soul, there was a lot of stuff pulsating in there, and maybe a lung.
* ''WesternAnimation/TheRenAndStimpyShow''.
** For a specific example, one episode begins with Ren and Stimpy being hit by a bus, and in order to survive they're stitched together. They then get jobs as freaks at a circus, and the first freak they meet has ''the lower half of a human growing out of his chest''. And it's TruthInTelevision; it's known as [[http://en.wikipedia.org/wiki/Parasitic_twin parasitic twins]].
** When Ren pulls out the nerve endings from his mouth with tweezers.
** This ''is'' the show that popularized GrossUpCloseUp.
** "The Cat That Laid the Golden Hairball". Stimpy runs out of hair to lick up and swallow; Ren doesn't have enough, but Bubba is hairier than a Greek. Stimpy tries to stop at one revoltingly hairy arm, but Ren goes, "Where are you going? Your plate's still full!" Cue shot of Bubba's hideous back. Then, a shot of Stimpy trying to speak around the mass of black [[UnusualEuphemism clocksprings]] in his ''mouth''. AAAAGH
** The entirety of ''Adult Party Cartoon'', and how. For the most extreme example, see "Onwards and Upwards", which was intentionally created as the most disugisting ''Ren and Stimpy'' episode ever. There were also parts of "Fire Dogs", involving the Chief's digestion problems, and "Ren Seeks Help" with Ren's actions toward several of his victims that weren't particularly pleasant.
** Hard to believe now that this show was ''ever'' on freaking ''Creator/{{Nickelodeon}}'', let alone that it started out there. It's something you would have thought MTV would produce, not Nicktoons.
*** This show was on MTV for a while...
* ''WesternAnimation/TheMarvelousMisadventuresOfFlapjack''.
** The scene where all the citizens of Storm-A-Long turn into [[GrotesqueGallery hideous beings]] straight out of an Creator/HPLovecraft novel due to Flapjack's pet rat giving them the [[TheBlackDeath Black Plague]]. Also the episode "Fancy Pants": it ends in about the same way as Mr. Creosote's scene in ''The Meaning of Life''. [[{{Squick}} Ewww.]]
** How about the episode in which Flapjack finds a "baby". The creation of the baby involves Flapjack taking some of K'nuckles' parts for the baby while he sleeps.
* ''WesternAnimation/RegularShow'' has the episode "Rigby's Body" where Rigby eats so much junk food that his soul is ripped from his body, but THAT'S not the gross part! The gross part is when Rigby eats a '''FRIED SHAKE'''. Sure, it's known that [[FridgeBrilliance raccoons will eat almost anything]], but GAH!!
* ''WesternAnimation/CodeNameKidsNextDoor'':
** '''''[[EyeScream PINKEYE.]]'''''
** Giant chubby, shrieking mutant lice eating everyone's hair, Ugh. Complete with chewing sound effects.
** When watching Op. TOMMY, think back to the last time your nasal passages were severely congested. Sure brings back memories, don't it?
* ''WesternAnimation/AquaTeenHungerForce'':
** Probably the most extreme example is the time Shake microwaves Meatwad's kitten. Believe it or not, it's actually ''much'' worse than it sounds, especially when Meatwad tries to salvage the remains.
** Most of Dr. Weird's appearances count.
** There's the Tree Court steno tearing off strips of Carl's skin, to use as paper.
* In ''WesternAnimation/MonkeyDust'', the ants in the surgical incision!
* The creepy, [[DerangedAnimation acid-trip]] fight scenes from ''WesternAnimation/{{Superjail}}'' would most definitely qualify.
** Among all the carnage and supernatural madness, there's one scene that is fairly low-key but no less disgusting. When the lunchladies spoil Alice's meal in the episode "Nightshift", by putting all kinds of stuff in the dishes, from cigarette butts to snot. Don't eat before seeing the episode.
* ''WesternAnimation/EdEddNEddy'':
** At one point, Ed starts sucking on a rain gutter that is filled with the usual detritus one finds in a rain gutter - that is, rotten leaves - then ''swallows it''.
-->'''Edd:''' ''Ed, don't talk with your mouth full!''
** Sarah at the end of "Run Ed Run". Her body was stuffed with full jawbreakers. Ew.
** "Luck of the Ed": Ed under a microscope. It even shows a strange parasite with a monobrow living in his dandruff-encrusted hair.
-->'''Edd:''' Ed, there's a new invention called ''soap''. Have you heard of it?
** Ed's room, a lot of what Ed does (particularly if it involves his tongue), a few things that Eddy does, and kinda the whole show in general.
* ''WesternAnimation/RobotChicken'' has the sketch where two guests at a filthy restaurant are served an unappetizing meal. The cook then kills a bug and places it on top. And then there's the other sketch with the booger escaping the kid's nose...Ew...
* Any "Yuckie Duck" cartoon short from the ''WhatACartoonShow'' overfills with this.
* ''WesternAnimation/FamilyGuy'':
** The [[http://www.youtube.com/watch?v=4eYSpIz2FjU ipecac scene]].
** "Brian & Stewie". Brian eating Stewie's poop. It made [[EvenEvilHasStandards Stewie himself throw up.]] And then, he makes Brian lick up his vomit to wash the poop down.
* The ''WesternAnimation/AmericanDad'' episode "Gorillas in the Midst" has a hungover Steve [[VomitIndiscretionShot vomiting profusely]], followed by Francine confirming that Steve has been drinking by ''licking'' the puddle of vomit.
* ''WesternAnimation/SouthPark'':
** The ending of the infamous "Scott Tenorman Must Die" episode. Which becomes worse when "201" reveals that [[spoiler: Scott and Cartman share a father.]]
** There's also the pooping out of the mouth scenes from "Red Hot Catholic Love".
** The scene in "Bebe's Boobs Destroy Society" of Wendy getting a boobjob. Not only does the surgeon RIP the implant incision open with what looks like a SHOEHORN, but he's so reckless and incompetent at putting the implant in that he splatters her blood everywhere in a way that realistically would permanently deform her torso and most likely kill her from blood-loss. Doubles as NightmareFuel.
** Randy's dick exploding and covering the room with his sperm in "Over Logging"
** Kenny eating the manatee spleen, vomiting it out, and eating it again from "Fat Camp".
** "The Tale of Scrotie [=McBoogerballs=]", in which the boys write a disgusting book that's so gross, nobody can read it without vomiting.
** [[Film/TheHumanCentipede HUMANCENTiPAD.]] That is all.
** The scenes in "I Should Have Never Gone Ziplining" in which we see Cartman's digestive system from the inside. A word of advice: Do not watch that episode when eating, you might just lose your appetite.
** From "Sarcastaball", the scenes where ''they drink Butters' semen''.
** From "The New Terrance and Phillip Movie Trailer", the scene where they open the door to Stan's house, only to find that ''the entire house has been flooded with Shelly's period blood'', all because they didn't give her tampons.
* ''WesternAnimation/{{Metalocalypse}}'':
** Jean-Pierre's hacked-up-by-a-helicopter body pieces being kept alive on life-support (honestly, seeing him sewn back together wrong is a relief after that) in episode one, and Dick Knubbler's eyes exploding at the end of the second episode.
** Or how about the episode where the band drinks a bottle of bleach in order to give the illusion that they are healthy?
** Or Murderface's guest appearance on a family sitcom? He shows up at the door holding the top half of the family dog.
* ''WesternAnimation/TheMightyB'' has a scene where Bessie tries to get chicken pox and goes to the length of breaking into someone's house, taking their thermometer out of their mouth and eating the massive ball of phlegm, mucus, and Zeus-knows what stuck on it to do so.
* As if [[FutureBadass Future]] [[IncrediblyLamePun Fatass]] [[WesternAnimation/DextersLaboratory Mandark]] wasn't gross enough (being so obese that he has to be carried by a crane in his ass), his fate wasawful. Losing his reign of terror causes his fat to go from his stomach to his head, popping it in the process. Nothing is left but his squishy brain.
* ''WesternAnimation/{{Felidae}}'':
** The nightmare sequence where a demonic Gregor Mendel makes thousands of rotting cat corpses dance like marionettes. ''And then the corpses start falling apart.''
** [[spoiler:The pregnant cat that was murdered. Her stomach was sliced open and the ''fetuses'' were spilling out.]]
* ''WesternAnimation/TotalDramaIsland'': The EatThat episode. You know the one I'm talking about.
** There are three episodes with challenges that provoke this: Brunch Of Disgustingness, I Triple Dog Dare You, and Chinese Fake-Out.
* ''WesternAnimation/AvatarTheLastAirbender'':
** Katara learning to waterbend using, uh, her own sweat.
** Also, [[FanDisservice Lo and Li at the beach.]] Zuko certainly agrees.
** Bloodbending is both this and horror incarnate. It gets even worse in ''WesternAnimation/TheLegendOfKorra''.
* Several moments in ''WesternAnimation/RockosModernLife'' qualify:
** One particular moment in the episode "Tickled Pinky" Rocko takes his dying appendix to a carnival at one point. While they're riding a roller coaster a crazy bear who's scared of the ride clings to Rocko's head at one point ripping open his eyelids and exposing his brain inside his head.
** In "No Pain, No Gain" a bull gets his arms ripped off while blood squirts from the stumps and you can see bones and muscle on the ground next to the severed arms.
** In "In-Flu-Enza":
*** While Rocko is waiting for his appointment at the hospital a bird who's smoking a cigarette coughs up his heart and dies.
*** In that same episode Retch the hotdog rips off the top of Rocko's head with visible blood and removes his brain only to pop it.
* Every single episode of ''WesternAnimation/DrawnTogether'' contains at least one incredibly disgusting or shocking scene.
** A particular example happens in the episode ''Dirty Pranking No. 2'', which focused on a habit Spanky has of [[{{Squick}} defecating on pizza and showing it to the deliveryman.]]
** The many GrossUpCloseUp [[FanDisservice shots of Toot]] in several episodes.
** Toot´s habit of constantly cutting herself.
** Several BodyHorror moments in the same show, also count.

* The Music/{{Gorillaz}} MTV cribs skit, starring [[UncleanlinessIsNextToUngodliness Murdoc]], had some thoroughly gross moments; such as Murdoc peeing over the side of the bathroom stall and ''into the next one,'' and the [[FanDisservice ending close-up on his ass]]. Interestingly, this is not the last time we would see him in a thong, nor the only time he's portrayed playing the piano naked. [[WalkingShirtlessScene Murdoc's an interesting fellow.]]
** Murdoc's ass in general. WHYYYY.
* ''WesternAnimation/XiaolinShowdown'' has plenty of this, including Clay eating a greenish, moldy piece of pizza he finds under the couch, Omi's earwax, and basically anything involving Cyclops (including Jack at one point having to change his diaper.) Also, Master Fung's feet seem to be [[BrainBleach unspeakably disgusting]] to the characters in-universe (other than Dojo, but let's not go there), but they don't actually look that bad to us.
* The ''WesternAnimation/CourageTheCowardlyDog'' episode "Curse Of Shirley" features Eustace having a raincloud cursed onto him and it follows him everywhere to the point where he has fungus growing on his body. As if that wasn't bad enough, he proceeds to pluck out his own body fungus and shove them into Muriel's mouth.
** And speaking of fungus, the villain of one episode was a sentient fungus that took control of his foot. Also, it was a mobster. And the only way to get rid of it was using dog spit. And at the end of the episode, it took control of Courage's tongue. Deeeeeees-gusting.
* In ''WesternAnimation/IceAge: A Mammoth's Christmas'', there is a scene where Peaches pulls a huge amount of earwax out of her ear (eight pounds to be exact, according to what she sings in their 12 Days of Christmas song).
* ''WesternAnimation/{{Shrek}}'' thrives on this (both the character and the movies).
* In ''WesternAnimation/{{Frankenweenie}}'', we are treated to sights such as cat feces in the shape of letters, mutant sea-monkeys [[spoiler:[[LudicrousGibs exploding with liquidy guts splattering everywhere]]]], and [[spoiler:said cat being impaled]].
* ''WesternAnimation/EightCrazyNights'' has the scene where Davey sends Whitey down the hill in a port-a-potty, and emerges covered in shit. Davey then sprays him with a hose, causing him to freeze, and he is un-thawed by deer that lick the ice (they even get shit all over their teeth). "Smell ya later Poopsicle!"
** Also, later on, a bunch of kids blow gallons of snot out of their nose from laughing hysterically over an ([[SoUnfunnyItsFunny unfunny]]) joke, and said deer shit all over while laughing about it too.
** The jockstrap-eating scene should also count.
* In ''WesternAnimation/{{Kablam}}'', when Stinky Diver threw up in an early episode of ActionLeagueNow. It looked like baloney with stuff on it.
* The one thing everyone forgets that is so disturbingly gross is [[DannyPhantom Dash's]] underwear which is full of holes and has a smoking trail of green stink. It's so bad that Danny and the trio scream in horror. The worst part, the underwear got a close up leading to this gem:
--> '''Tucker''': I don’t know what’s scarier. The underwear, or the fact he carries them around in his coat!
** And the purpose of the underwear makes it even more sickening.
--> '''Dash''': And when you taste defeat you have to eat ''THESE''! [''Pulls out the unspeakable disgusting underwear.'']
** And later...
--> '''Sam''': Salt. [''Hands Danny, who is sitting at the table surrounded by banners and other teens, the salt.'']
--> '''Tucker''': Pepper. [''Hands Danny the pepper then leaves.'']
--> '''Sam''': Clothespin. [''Places a clothes pin on Danny's nose then leaves.'']
--> [''Dash’s hands place a covered dish on it. Danny looks down upon it. One of Dash’s hands lifts the handle on the cover, revealing the torn, smelly underpants with a stream of stink coming out from it.'']
--> '''Dash''': Bon Appa-Tighty Whitey, loser!
--> [''Danny lifts the underpants with his hand and looks at it. He groans as his face goes all green and his cheeks bulge with puke. Purple sickly-stars flash in front of him.'']
* ''WesternAnimation/AdventureTime'' is no stranger to gross-out comedy, but perhaps the most disturbing example from the show that succeeds in making the characters themselves feel ill along with the audience is the virus-laden video in "A Glitch is a Glitch". For those who don't want to watch it [[http://www.youtube.com/watch?v=NX_vcjZmQ9w here,]] it's a scratchy video featuring a pale, [[TheRing Samara-like]] girl with long black hair in a dimly-lit room covered in black mold. She then proceeds to stuff her hair into her mouth and slowly swallow it whole. Though that might not seem nasty, her pained facial expressions plus the metallic, guttural choking and retching noises she makes with each swallow makes it painful to watch.
** Also Finn's foot rash in Princess Potluck. Bad enough to make Jake want to puke the two times he sees it.
** In ''Breezy'', the implied sex between Finn and LSP. A lumpy mass with Pendleton Ward's voice + an underage boy. Yeah.
* The ''WesternAnimation/CatDog'' episode "Teeth For Two" normally the show didn't have a lot of gross out humor but this episode was pretty disgusting, we find out that what one of them does to their teeth it has the opposite effect, as Dog continues to eat garbage and junk food Cat's teeth become increasingly rotten. At one point when Cat tries to brush Dog's teeth so his (Cat's) teeth will be perfect he turns himself inside out and crawls inside Dog's mouth and we see what is essentially a skinned alive Cat with pulsating veins and his nerves and muscles exposed. Later they get into a fight and destroy each other's teeth and by the end of it they both have some pretty nasty looking teeth some of which are hanging by nerve endings, and at the end when they get teeth donations they develop a skin condition in which several boils form on their body and squirt puss.