http://tvtropes.org/pmwiki/pub/images/mad_scientist.jpg
[[caption-width:235:They laughed at me at the university! [[TheyCalledMeMad They called my theories mad!]] But I'll show them... I'll show them ALL! [[LaughingMad AH HA HA HA HA HA!!!]] ]]

-->"I remember those nights, planning technologies that didn't exist yet, outsider science, futurist dreaming, half-magical. The things I could do outside the university setting, now that I didn't have to wait for the pompous fools at the college! I was building another science, my science, wild science, robots and lasers and disembodied brains. A science that buzzed and glowed; it wanted to do things. It could get up and walk, fly, fight, sprout garish glowing creations in the remotest parts of the world, domes and towers and architectural fever dreams. And it was angry. It was mad science."
-->--'''Doctor Impossible''', ''SoonIWillBeInvincible''

They're scientists, they're somewhat scatterbrained, their practice is questionable, and they are frequently [[EvilGenius working for the bad guys]], often building [[GadgeteerGenius implausible gadgetry]] or [[NoPlansNoPrototypeNoBackup slightly ridiculous]] [[WaveMotionGun superweapons]]. They tend to wear lab coats, have [[EinsteinHair wild hair]], and speak with [[FakeNationality put-on]] Central European accents (based on the many scientists who fled Central Europe from [[WorldWarTwo the Nazis and the Soviets]]). Sometimes they will talk like Peter Lorre, or engage in SesquipedalianLoquaciousness. Often they will possess [[OmnidisciplinaryScientist more than one]] MorallyAmbiguousDoctorate. Sometimes they will consider themselves to be [[ProfessorGuineaPig a certain species of rodent]]. Typically comes equipped with a MadScientistLaboratory possibly on a tropical island or in a European [[HauntedCastle castle]]. He'll often be assisted by TheIgor.

Probably inspired by several people fictional and real: [[FrankensteinsMonster Doctor Frankenstein]], Rotwang of the silent movie classic ''{{Metropolis}}'' and Albert Einstein. It's worth mentioning that while prominent scientists through the ages have often been a little... off, they are not true mad scientists: to be a Mad Scientist, both you ''and'' [[ScienceIsBad the science has to be mad]]. The one person who's come closest to this in real life may have been NikolaTesla.

They tend to have vast stockpiles of AppliedPhlebotinum available, and are frequently the manifestations of a particularly egregious AssPull on the part of the scriptwriters. Mad Scientists often do a lot of [[HandWave hand-waving]] and cackling as they construct or summon the MonsterOfTheWeek or [[MrFixit repair]] the villain's HumongousMecha, which is usually only dimly visible in a gigantic foggy cloud of [[MrExposition expository]] TechnoBabble. When confronted about their amorality, expect them to shout that the true value of their work is ''"ForScience!"''

Some examples more than others emphasize that the [[ScienceIsBad bad science]] is incredibly broad-based. [[EvilutionaryBiologist Biology]], [[TechnicolorScience chemistry]], [[MadDoctor medicine]], physics are merely some of the mastered fields. (This may have been more realistic when scientists were "natural philosophers".) Technological mastery may include robotics, mechanical, electrical, and so forth, although in RealLife researchers of basic science such as university professors may not be that swift at using computers, for instance.

Despite being the type that should never attract women (unless a rare tragic figure), the MadScientist traditionally has [[MadScientistsBeautifulDaughter a beautiful daughter]] for the hero to fall in love with. Or perhaps a [[GuineaPigFamily family]] of [[TrulySingleParent much]] [[CloningBlues stranger]] [[ReplacementGoldfish provenance]]. An [[ScienceRelatedMemeticDisorder increasingly common take]] on this trope is that Mad Science is a ''[[ChronicVillainy disease]]'', either hereditary (in which case the afflicted may come from a [[InTheBlood long line]] of mad scientists), or transmissible through [[MemeticMutation contagious ideas]].

A MadScientist or two can be responsible for a SchizoTech world and fill it with the detritus of decades of worth of monster projects, MechaMooks, etc, and be perfectly willing to [[TheydCutYouUp vivisect any interesting specimens...]] [[WhatMeasureIsANonHuman human and non.]] They also might be the only ones able to resurrect LostTechnology. One that actually ''succeeds'' in [[TakeOverTheWorld taking over the world]] can become an EmperorScientist.

The opposite of this character is TheProfessor, a brilliant scientist who is unambiguously a hero; however, they overlap more and more often lately. The ReluctantMadScientist, a specific type, is a moral free agent who is sought after by both the villain and the hero. He is obsessed with his work and can't be held accountable. He is the only person who can build or disarm the {{MacGuffin}}, which he will gladly do for either side if asked because all he cares about is research. Often, nowadays, you'll see a good-aligned MadScientist (a TechnoWizard), whose job is usually providing the hero with their own stockpiles of AppliedPhlebotinum. This character will frequently be an example of TheMadHatter as well. It is in WebOriginal works, however, that mad scientists have come into their own as ''leading'' characters; it seems a lot of the eccentric folks of the Internet sympathise with these unhinged geniuses.

Now, if you excuse me, these gorillas won't cybernize themselves. Hm, should really put that in the next batch...

See also TVGenius, EvilGenius, and, inevitably, ScaleOfScientificSins.
----
!!Examples

[[foldercontrol]]

[[folder: Anime and Manga ]]
* Dr. Hell from MazingerZ is one of the first anime examples and fits this trope to a T.
** In some versions, Juzo Kabuto is amix of this and TheProfessor. And he has a handsome and HotBlooded grandson named Koji Kabuto, the main character.
* Professor Tomoe Souichi from ''SailorMoon''. To be fair, in the anime version he was possessed by a demonic being that lived in his eye; in the manga, he was just plain evil.
* Dr. Gero from ''DragonballZ''
* Washuu, from ''TenchiMuyo'' and its spinoff series ''PrettySammy'' (a heroic example).
* Dr. Franken von Fogler from the ''GiantRobo'' OVA was introduced as a classic ranting Mad Scientist. [[spoiler:The series subverts this trope, as successive flashbacks reveal more about his real motivations.]]
* Icchan from ''KidouTenshiAngelicLayer'' is often mistaken for a MadScientist; he seems to encourage it, making over-the-top dramatic entrances, speaking cryptically about his creations whenever he can, and wearing his lab coat all the time.
** However, his invention makes sense, is based on diligent research, operates on the notion that the principles discovered in previous discoveries can lead to new ones, is dependent on capitalism to provide funds and is profitable for mankind in general. Mad Scientists everywhere are very, very disappointed in him.
*At least a third of the major characters in ''NeonGenesisEvangelion'' are mad, or at least amoral, scientists.
* Mayuri Kurotsuchi from ''{{Bleach}}'' is an extreme example, an unholy hybrid of a {{mad scientist}} and an [[AxCrazy outright sociopath]], openly boasting of the thousands of souls he's tortured to death in his 'studies'. Yet he leads one of the Soul Society's 13 squads (his contains lots of [[QuirkyMinibossSquad quirky]] [[TheIgor assistants]]) and is seemingly a valued member. You begin to see the problem that the rest of Soul Society has with the administration... Just to hammer it home, he even has a [[MadScientistsBeautifulDaughter daughter]] whom [[ArtificialHuman he made himself]]. His Arrancar equivalent is Szayel Aporro Grantz, who shares his twisted science. Urahara Kisuke is also very much a scientist and very much whacked out. There's a distinction between him and the other two, however, in that while Urahara is a walking moral gray area, he's not sociopathic or out for bloodshed.
**[[spoiler:It has now been been revealed each of the Espada represent an aspect of death. Szayel represents madness, officially making this trope played amusingly straight.]]
** Also [[spoiler:Aizen]] could count as well, what with his experiments on both shinigami and hollows, and his whole [[spoiler:[[AGodAmI I will become God]] thing.]]
* ''{{Fullmetal Alchemist}}'', instead of dealing with the MadScientist, revives its predecessor-trope, the almost forgotten Mad Alchemist (see below).
** TheMovie introduces a scientist who is severely ticked at the world's alchemists for making his work worthless. The "mad" part of this shows up when he reveals that he discovered Uranium and threatens the Elrics with a ''hand-held nuke''. Clearly he never tested the thing.
* Dr. Ni Jianyi from ''{{Saiyuki}}''.
* ''WeissKreuz'' is almost as fond of these as it is of {{Mad Artist}}s - see particularly Takatori Masafumi, and Tsuji Mayumi in ''Weiss Kreuz: Glühen''.
* Dr. Jail Scaglietti of ''MagicalGirlLyricalNanoha Strikers''. In fairness, it turns out that [[spoiler: he's an ArtificialHuman who was specifically created to be that way]]. Unlike most of the {{Gadgeteer Genius}}es here, actually refers to himself as an engineer.
** And we have Precia Testarossa, who snapped over the [[spoiler:loss of her daughter Alicia]].
* ''[[{{Gunnm}} Battle Angel Alita]]'': Desty Nova. Mad laugh, human experiments, cloning, nanomachines, lack of morals, the whole works, and he's ''proud'' of it.
* Dandankyukyu (called Dantalion or The Professor) from ''ShakuganNoShana''. He is [[LargeHam outrageously excitable]] and creates his mad experiments ForScience, and not necessarily for evil means. (One suspects that if he weren't contracted to the bad guys he'd be mostly harmless). Bonus points, he looks exactly like Father Anderson from ''{{Hellsing}}''.
* Speaking of Hellsing, there is The Doktor, chief scientist of the [[StupidJetpackHitler Millennium Group]].
* The titular Dr. Kishiwada of ''Dr. Kishiwada's Scientific Affection.'' Clinically insane and more than a little sociopathic.
* Ginias Sakhalin from {{Gundam}}: The 08th MS Team, the head of the Apsalus Project, which could be best described as a miniature [[StarWars Death Star]] that kills cities instead of planets. He starts out relatively sane if overly dedicated, but he deteriorates as time goes on.
** He also has [[MadScientistsBeautifulDaughter Mad Scientist's Beautiful]] [[strike: [[MadScientistsBeautifulDaughter Daughter]]]] [[MadScientistsBeautifulDaughter Sister]]. Who is the [[CapuletCounterpart hero's girlfriend]].
* The Elder in ''ChronoCrusade'' is a mild example of this trope. He's not ''completely'' insane, but his inventions tend to be quirky at best and downright dangerous at worst. Some of the things he's responsible for in the series include purposefully allowing [[HotBlooded Rosette]] to steal an experimental bullet with a demon trapped inside so he wouldn't have to test it himself, and apparently fusing a friend with demonic legion in order to make him a better fighter. Oh, and he's a DirtyOldMan to top it all off.
* Nina Einstein from ''CodeGeass'', a Teenage Mad Scientist Girl. She is particularly known for being a {{Psycho Lesbian}} and inventing weapons of mass destruction.
** And the [[CargoShip table incident.]] [[NeverLiveItDown Don't forget the table incident.]]
** Earl Lloyd Asplund is an older, slightly more comedic version of the trope. His BunnyEarsLawyer status has earned him the FanNickname "Lloyd Aspie".
*** Lloyd plays with the trope as while he is eccentric and disrespectful, he is fully aware that he is a mad scientist. Also, he is the only (non-royal) noble in the series to have no lust for power and not be racist, and in that respect is in some ways the OnlySaneMan.
* Another one is Grace O'Connor from MacrossFrontier. Though she doesn't heavily advertise that she ''is'' a scientist in the first place, in fact [[EvilutionaryBiologist she is]], and not the worst one. Given that she's also a HotScientist, and what a [[TheChessmaster scheming]], [[ForScience amoral]], and utterly {{badass}} MagnificentBastard she comes in the end, it's simply unfair to leave her out.
*{{Sekirei}} has a few, but the biggest, craziest, and downright [[LargeHam hammiest]] of them all is Hiroto Minaka, MBI's [[CorruptCorporateExecutive psychotic and manipulative CEO.]] He's hinted to be behind the discovery of the original Sekirei and the making of the current ones, and is CONFIRMED to be [[ChessMaster manipulating every single person in the series towards his own bizarre ends]] and [[JerkAss making every character hate him in the process]], but earning [[DracoInLeatherPants massive fan love]] for his ImpossiblyCoolClothes and general {{CrazyAwesome}}ness.
* [[HeroicSociopath Professor Franken Stein]] of ''SoulEater'', whose love of dissection is played for laughs early on. [[spoiler:The "mad" aspect becomes important later on, as madness is [[CosmicHorror somewhat more concrete]] in this world.]] [[MagnificentBastard Medusa]] definitely counts as well.
** Stein's likening for dissection ''is'' played for laughs, but it's also what he seriously would have done to Medusa given the chance (and Spirit, and Maka, and Kid, and anyone he saw as interesting..). In the witch's case he settles for dismembering her and shoving a scythe blade into her skull for good measure.
* GetterRobo has a few. Saotome is the most famous example, though he's very low-key (except in the ''Armageddon'' OVA) about it and fairly normal on the surface. Professor Shikashima on the other hand has several screws loose (and indeed, actually ''has one lodged in his skull'') but his craziness is mostly played for laughs. In GetterRobo ?? [[spoiler:Hayato replaces Saotome as the leading scientist, with his trademark AxCrazy streak]].
* Some of the {{Naruto}} villains get into this, most notably [[SmugSnake Orochimaru]] and his MadDoctor BastardUnderstudy, [[TheMole Kabuto]].
* Hakase of MahouSenseiNegima qualifies. So does Chao.
* Hiroshi from ''{{My Dear Marie}}'' builds himself a {{robot girl}} [[ReplacementGoldfish who both looks identical and has the same name to a woman he has a crush on]]. When the two meet by chance, he tells everyone that they're [[LikeBrotherAndSister siblings]] as a cover story.
* Uh, guys? FrankenFran is here and feeling a little left out. She's also a MadScientistsBeautifulDaughter (If you don't mind the stitches), who [[BodyHorror completely lacks]] [[HighOctaneNightmareFuel any understanding]] [[NightmareFuelStationAttendant of the word]] squick. And she does half of it ForScience!, and the other half to save lives...no matter the cost to quality of life.
* While Shiho Miyano of DetectiveConan may not qualify as a Mad Scientist, since she was forced into doing her research, her father certainly does. The series specifically mentions that her father was considered a mad scientist even by the standards of the Black Organization. That's pretty mad.
* One story in ''Kindachi Case Files'' features the story of a mad scientist who, during WWII, chopped up soldiers and tried to sew the pieces into the ultimate human. [[spoiler:It turns out that the ''real'' "mad scientist" was a pharmaceutical company that tested experimental drugs on six patients, all of whom died.]]
* This long, and no mention of {{Pokemon}}? The anime LOVES this trope, especially for villains:
** Dr. Fuji, the {{Reluctant Mad Scientist}} who created Mewtwo for Giovanni [[spoiler:in hopes he'd be able to revive his dead daughter]]
** Professor Sebastian, who likes [[GadgeteerGenius messing with radio waves]] to lure Pokemon/force them to evolve
** Dr. Namba, the campiest mad scientist on the list, who builds frequently ridiculous contraptions to capture Pokemon for Team Rocket. [[BerserkButton Don't get his name wrong, whatever you do.]]
** Dr. Yung, from Mastermind of Mirage Pokemon, who [[spoiler:is revealed to be the titular "mastermind", attempting to take over the world with super-powerful Pokemon holograms]]
** Butler, in the sixth movie, [[spoiler:laughed out of Team Magma for a failed attempt to re-create Groudon]], who now travels as a circus magician, [[spoiler:but tries his experiment again using [[PoweredByAForsakenChild Jirachi as a power source]]]]and ends up having it work a little too well.
** Zero, the {{yandere}} villain of the eleventh movie, an assistant for an aborted project. After being abandoned by his mentor, obsession drives him to [[ThereIsNoKillLikeOverkill take reviving it a bit too far]]. And by "take it a bit too far" we mean "threatening anyone who stands in his way with poisonous gas or a [[HumongousMecha giant robot"]].
** Cyrus, leader of Team Galaxy and OmnicidalManiac.
* Inverted with Irie, from ''HigurashiNoNakuKoroNi''. While he did [[spoiler:do vivisections on people]], and does act a bit "[[{{Lolicon}} odd"]] toward Satoko, he's a honestly nice, smart father figure.
* Why is Dr. Mashirito of DoctorSlump not mentioned yet?
[[/folder]]

[[folder: Comic Books ]]

* The original incarnations of Comicbook/{{Superman}}'s archenemy, Lex Luthor. In the years since, he's also been a CorruptCorporateExecutive and a [[PresidentEvil villainous politician]].
* The Mandarin is a Mad Scientist enemy of Iron Man. He spends his time inventing mind-controlling super-cancers that run around like a cross between the Blob and the Borg. Or inventing orbiting Hate Rays to destroy the world with madness.
** Is this the same Mandarin who wielded the [[NinjaPirateZombieRobot Ten Rings of Power that were the power source of a spaceship belonging to alien dragons]]? It's like the writers aren't sure if they want him to be an [[EvilOverlord evil sorcerer overlord]], a MadScientist, or both.
***Yes, some of his inventions were adaptions of said alien's technology. Of course, depending on the writers, the Mandarin has varying levels of superhuman martial arts, too, so he really is some kind of every-villain.
****The Mandarin is basically Dr. Frankenstein and Remo Williams fused into one guy.
* Doctor Sivana and his family are similarly the archenemies of [[{{Shazam}} Captain Marvel]] and friends. He's a five-foot-tall gnome of a man with a chrome dome, huge ScaryShinyGlasses, and more often than not a white lab coat. His stated goals (in no particular order): To become Rightful Ruler of the Universe in fact as well as in name; to spread evil, cruelty, and nastiness throughout the cosmos; and to humiliate, discredit, and ultimately ''KILL CAPTAIN MARVEL!'' Heh heh heh heh!!! What, exactly, his [[UglyGuyHotWife incredibly attractive and affectionate]] late wife saw in him is a total enigma.
* A heroic Mad Scientist in TheDCU is Doctor Magnus, creator of the Metal Men.
* In the MarvelUniverse, AIM (Advanced Idea Mechanics) are a terrorist organization of Mad Scientists, who wish to overthrow the world's governments and institute a technocracy.
* TheDCU comic ''[[FiftyTwo 52]]'' had a secret conspiracy who was kidnapping Mad Scientists, good and evil, for a nefarious goal.
* ...and many, many, ''many'' others. Mad Scientist is possibly ''the'' default comic-book bad guy, and is a common vocation for good guys, as well.
* The Ultra-Humanite (arguably comics' first supervillain) who actually transferred his brain from the standard baldie-in-a-labcoat mad scientist's body into that of a beautiful woman. He was only another Mad Scientist in the GoldenAge comics, but in the series ''The Golden Age'', he becomes the arch villain, but [[spoiler:[[VillainWithGoodPublicity poses as a hero and gets the medal of honor]]. He saved Hitler's brain, too. And put it in an invincible super-body]].
* D.A. Sinclair of ''{{Invincible}}'' is easily one of the most sadistic mad scientists in fiction. He started making zombielike techno-organic minions, Re-Animen, from dead bodies, which is bad enough. But he eventually moved on to ''live'' subjects, kidnapping his roommate and ''tearing out his vocal cords'' so that he couldn't scream while he operated on him (D. A. is a college student, after all, and can't afford anaesthetic). And he tore his arm off and overrode his free will. Then he started duplicating the process on homeless people. Naturally, the US Government saw to it that he served no jail time when he was caught, and gave him a cushy job making Re-Animen for military use.
* Dr Mindbender from ''{{GIJoe}}'' is particularily mad. Cloner, Genetic Engineer, Robot designer and master of mind control and inventer of many of Cobra's bizarre superweapons. That he's bald, usually shirtless and has pecs like melons only enhances his image of insanity. He even [[spoiler: installed mind control chips in several prominent Cobra members, and prepared for his own death by creating a clone backup]]. Oh, and before he became a mad scientist, he was a... benevolent orthodontist. Until his freak orthodontics accident (seriously).
* Simon von Simon from ''LittleGloomy''. He's got it all, from his powerful machinery, futuristic inventions (such as the television and the microwave. Before you say anything, he invented them before anyone else did), hunchbacked HalfheartedHenchman, to his seething rage for everybody but himself. Of course, the fact that his plans for world domination were motivated by Gloomy dumping him, and the fact that the series calls him on not marketing his fantastic creations to get on top in a less freaky way undermines his menace somewhat; This, in turn, is offset by his army of ravenous zombies.
*Dr Scyk from the Danish comic-strip "Dr Merling".
*Several villains in the BlakeAndMortimer comics fall under this trope. The most notable being:
**Wade/[[spoiler:Jonathan Septimus]]in "The Yellow M"
**Miloch Georgevich in "Sos Météores" and "Le Piege Diabolique"
**Voronov in "La Machination Voronov". Who also ends up being something of a KarmaHoudini.
* In ''YTheLastMan'' geneticist Dr Allison Mann claims she was illegally cloning a nephew who needed a bone transplant. She later admits this story was fictional to gain Agent 355's sympathy rather than be thought of as a 'mad scientist'; her actual motive was to spite her father who was nearing success in cloning the first human. [[spoiler: After several red herrings we encounter the REAL mad scientist is in fact Allison's father, who was seeking to clone his daughter so he could be a better parent the next time round, yet who also sabotaged Allison's cloning experiment out of sheer spite and may have accidentally caused the plague that all but wiped out all males.]]
* In addition to Dr. Robotnik/Eggman, the Archie ComicBook/SonicTheHedgehog comic has Dr. Finitevus and Dimitri, both of whom work for the Dark Legion, a gorup who believe in self-augmentation with technology.
* Hank Pym (aka Ant-Man aka Giant-Man aka Goliath aka Yellowjacket aka The Wasp). Just take for example his origin story:
-->'''Panel of Scientists:''' "You should stick to practical projects"\\
'''Hank Pym:''' "No! I'll work only on things that appeal to my imagination...like my latest invention."\\
'''Panel of Scientists:''' "Oh...what's that?"\\
'''Hank Pym:''' "I won't tell you yet! You would only laugh at me as you've done before! But when I've finished it, I'll show you! Then you shall know I'm a greater scientist than ''any'' of you!"
* Marvel's High Evolutionary. The man built his own '''''planet'''''!
* Mr. Freeze used to be one of these, with no real backstory, just the whole freezing schtick. Then came ''BatmanTheAnimatedSeries'' which gave him [[IncrediblyLamePun chillingly]] tragic backstory and motivation, turning him more into a villainous [[TheWoobie Woobie.]] This new version of the character was {{RetCon}}[[CanonImmigrant ned]] into the main DCU.
* Barry Ween, the 10-year-old with a 4-digit IQ in the eponymous series THE ADVENTURES OF BARRY WEEN. A representative quote: "Hey -- put that down! That's the controls to my weather satellite! You just flooded Norway!" [short pause] "Well... it's only Norway..."
[[/folder]]

[[folder: Film ]]

* Most of the traditional image of the MadScientist probably derives from various adaptations of MaryShelley's ''[[FrankensteinsMonster Frankenstein]]'', especially the 1931 movie: "It's alive! IT'S ALIVE!" Note that the original book is wildly different - see below.
* The 1931 ''[[FrankensteinsMonster Frankenstein]]'' and other horror films of the time also drew heavily for their portrayals of mad scientists on Rotwang in Fritz Lang's classic 1927 SF film ''{{Metropolis}}''. Rotwang, in turn, draws on the MadScientist depictions of Frankenstein in nineteenth-century stage melodrama.
** It's worth pointing out that Rotwang from ''{{Metropolis}}'' is not only the earlier Trope Maker, but was himself largely inspired by the popularity of the wild-haired, heavily accented Einstein and other "eccentric German physicists" at the time who were upending people's notions of the limits of science in an unsettling manner. They helped inspire the image of the {{Reluctant Mad Scientist}} who is obsessed with his research and doesn't really expect it to be misused.
* ''AttackOfTheKillerTomatoes'': Dr. Putrid T. Gangrene qualifies, what with his diabolical plans to conquer the world with giant killer tomatoes, tomatoes turned into people, people turned into tomatoes, etc. etc. Don't call him mad, though. HE IS NOT MAD. A little angry sometimes, but not mad!
* The ''BackToTheFuture'' trilogy has Emmett L. Brown, who is a bit more cuddly than your average MadScientist.
* [[TheCabinetOfDrCaligari Dr. Caligari]] is a little bit of this and a little bit of CircusOfFear.
* ''DayOfTheDead'' (1985). Dr. Matthew Logan, nicknamed "Frankenstein" by the soldiers. He is so obsessed with his work he fails to consider how the soldiers will react to him cutting up their deceased comrades for his experiments.
* The title character of ''DoctorStrangelove, or How I Stopped Worrying and Learned to Love the Bomb''
* Vincent Price in ''EdwardScissorhands'' might just be the kindliest MadScientist ever. His second-most-impressive creation (after Edward) is a giant cookie-making machine.
* The Woody Allen comedy ''Everything You Always Wanted To Know About Sex *But Were Afraid To Ask'' has a skit featuring Dr. Bernardo, a mad sex analyst whose experiments include measuring premature ejaculation on a hippopotamus and building a 400-foot diaphragm. ("Contraception for the entire nation at once!") The segment ends with Allen's character battling one of the doctor's creations - a gigantic, disembodied human breast.
* Seth Brundle in the 1980's remake of ''TheFly'' but he doesn't start out that way.
** The original was the inspiration for Dr. Cockroach in ''MonstersVsAliens''.
-->"I'm not a quack, I'm a mad scientist!"
* The original {{Godzilla}} had Dr. Daisuke Serizawa who invented the Oxygen Destroyer that ultimately kills Godzilla. Though, he isn't evil.
* Dr. Shiragam from ''Godzilla VS Biollante'' whose experimental fusion of [[BiologicalMashUp Godzilla's DNA, Rose DNA, and the DNA of his deceased daughter]] ends up causing the creation of Biollante. He's not evil either, but he's certainly mad with grief over the loss of his daughter.
* In ''Igor'' mad scientists are like rockstars, and one of the most well known is Dr Schadenfreude.
* Dr. Michael Hfuhruhurr in ''The Man With Two Brains'' eventually becomes one of these - or, rather, a parody of one:
-->'''German Detective''': You're playing God!\\
'''Michael''': ''Somebody's'' got to!
* Dr. Frank N. Furter from ''TheRockyHorrorPictureShow'', who is also a VillainousCrossdresser.
* ''TheSpiderwickChronicles'' has Arthur Spiderwick.
* Walter Kornbluth from ''{{Splash}}''. He is also Butch Hartman's inspiration for the character of Mr Crocker on ''Fairly Oddparents''.
* The film ''Terror Of Mechagodzilla'' has the character of Dr. Mafune who not only turns his own daughter into a cyborg, but he also invents a device that allows him to control the sea monster Titanosaurus.
* The Doctor aka [[spoiler:Rex Lewis]] AKA [[spoiler:Cobra Commander]] takes the role of the mad scientist in GIJoeTheRiseOfCobra.
* Dr Totenkopf from SkyCaptainAndTheWorldOfTomorrow
* The ''Ghostbusters,'' especially Egon.
* Dr Emilio Lizardo, AKA Lord John Whorfin, in TheAdventuresOfBuckarooBanzaiAcrossTheEighthDimension.
[[/folder]]

[[folder: Literature ]]

* In TerryPratchett's ''{{Discworld}}'' books, the Alchemists' Guild are also {{Magitek}} mad scientists. Inverted with the character of Jeremy Clockson, subject of the quote above, who has the detachment from reality and dangerous obsession of the typical MadScientist because (most of the time, and in a very specialised way) he's ''saner'' than normal people.
** {{The Igor}}s of the Discworld series. Though typically the assistants of a Mad Scientist, they're known to conduct their own experiments, such as growing noses with feet, and their own special version of "self improvement." Though to be fair, the Igors in general are remarkably GenreSavvy - they know their place in the chain, and how to react when that chain is shaken. In fact, the clan basically foists off the most 'modern' variant of their clan upon the Night Watch in an attempt to cease the corruption: that is to say, Mr. "Noses With Feet". Similarly, in ''Discworld/CarpeJugulum'', an Igor working for vampires revolts at their innovations and revives the old master -- not so much reviving the GoodOldWays as the Moderately Less Odious Old Ways.
** ''Making Money'' gives us Hubert Turvy, a mad ''economist''. With a really, really CrazyAwesome laugh.
* The inspiration for both Mary Shelley's novel ''[[FrankensteinsMonster Frankenstein]]'' and the adaptations which distorted Frankenstein into a MadScientist came from a much older literary and popular tradition about Mad ''Alchemists'', and their blasphemous, yet entertaining, obsessions with the creation of homunculi and the secrets of eternal life. So while the MadScientist might seem quintessentially modern, in fact he's OlderThanSteam at least. The most well-known remnant of the old 'Mad Alchemist' trope today is the Faust myth, and its literary adaptations in Marlowe's play ''Dr. Faustus'' and Goethe's epic poem ''Faust''.
** An interesting fact is that the 1910 silent film ''Frankenstein'' features a scene of monster's creation that is highly relevant to an alchemical procedure of palingenesis (re-formation of a once-living organism from it's ashes or from it's severed parts by heating). As far as ThisTroper knows, no other film adaptation involves this trace.
* Victor Frankenstein, as originally conceived in Mary Shelley's novel, was not quite a MadScientist. Although he sees himself as a descendant of Mad Alchemists, Shelley makes his character more rounded and his mental instability more subtly portrayed. However, within decades wildly popular nineteenth-century melodrama theatre adaptations recast him as a cackling Mad Alchemist.
* The King of the Mountain in Enid Blyton's ''The Mountain of Adventure''.
* [[http://comicsbyshaenon.free-forums.org/comicsbyshaenon-forum-6.html This forum story]], TheMadScientistWars, pretty much uses this trope as its foundation stone. The players are all fans of the above-mentioned Narbonic and its new successor, ''Skin Horse'' (about a government agency that basically cleans up after Mad Scientists), so it was only natural.
** This Troper, who is Andrew Tinker in the forum, would like to add that it's a pretty good example. Flying rabbits, lightning guns, nano-bots, and reality warping have all come into play.
* HPLovecraft definitely had one more than one MadScientist character.
** Herbert West. Just... Herbert West.
** The stories ''From Beyond'', ''At the Mountains of Madness'', ''The Dreams in the Witch House'' and ''The Shadow Out of Time'' spring to mind.
*** While all of the above feature scientists, only the one in ''From Beyond'' is a genuine MadScientist. While some of the others GoMadFromTheRevelation, they never adapt MadScientist mannerisms, instead getting more realistic nervous breakdowns.
* Arthur Machen's ''The Inmost Light'' written in 1894 contains a rather horrific version of this trope.
** Don't forget the one in ''Great God Pan'', either. While the novel seems desparate to make him slightly sympathetic, at least to a modern reader he comes off as a CompleteMonster. Yeah, lets practice some experimental brain surgery with a teenaged girl completely infatuated with you, and clearly incapable of truly informed constent. What could go wrong?
* Most of {{Doc Savage}}'s foes are mad enough to the point that their [[ScienceIsBad death machines could not have been a large scale threat]] after retrieval and close examination by Doc. [[AlternateCharacterInterpretation At least, that's what he says...]]
*Sadistic pavlovian Ned Pointsman, one of the main villains in ''GravitysRainbow''.
* Dr. Impossible, of ''SoonIWillBeInvincible'', suffers from "[[ScienceRelatedMemeticDisorder malign hypercognitive disorder]]". His mentor, Baron Ether, had the condition as well. Symptoms include [[FreakLabAccident not following safety protocols]] while [[ILoveNuclearPower working with high energy physics experiments]], [[XanatosGambit extreme long-term planning]], [[MechaMooks robotic servants]], [[DeathRay death rays]], ''[[ThirtyXanatosPileup extreme]]'' [[XanatosGambit long-term planning]], [[EvilLaugh maniacal laughter]], [[CutLexLuthorACheck wondering why you just didn't get a normal job while powering up the death ray]], and [[YesButWhatDoesZataproximetacineDO insomnia]].
* The villain of HilariBell's ''The Last Knight'' is a rare example of a mad scientist in a fantasy setting, performing dubiously ethical experiments in order to give magical powers to humans (as, in the story's universe, only plants and animals have magic).
* HGWells' Dr. Moreau from ''The Island of Dr. Moreau''. The titular vivisectionist isn't as early as Frankenstein, but he played a major role in shaping the trope. He had EinsteinHair - decades before Einstein. He had the MadScientistLaboratory - his island (and he likely brought tropical island laboratories into vogue). Cast out from society, with only [[TheIgor one assistant]]? Oh, yes. He did it all ForScience but used extremely painful methods that would give any PETA representative nightmares. Turned on by his own creations? Of course. Several films adaptations even give him a [[MadScientistsBeautifulDaughter beautiful daughter]] [[spoiler: of his own creation]]. He also provided the beginnings of the ReluctantMadScientist - he never intended to get revenge on the other scientists who cast him out, and in his own mind he had noble purposes for his work; it's only his (possibly willful) ignorance of how torturous his methods are that makes him less than a sympathetic character.
** Don't forget Dr. Griffin from HGWells' ''TheInvisibleMan'', too. All the evidence suggests that he was not entirely stable to begin with; after he [[FreakLabAccident manages to turn himself permanently invisible]], he becomes a murdering psychopath bent on domination who refers to himself as [[ThatManIsDead "Invisible Man the First"]].
* In JamesSwallow's {{Warhammer 40000}} BloodAngels novel ''Red Fury'', Caecus persists in his efforts to make replicae of Space Marines over his Chapter Master's overt disapproval. (His servant Fenn falls more under OldRetainer than TheIgor, because he vocally disapproves of it all.)
* Subverted to some extent in the George R.R. Martin-edited ''Wild Cards'' books. There are Mad Scientists a plenty, on both hero and villain sides. Or at least folks who have been infected with the wild card virus who are now determined to build androids, giant mecha suits and all manner of mad-sciencey devices. The kicker is that the inventions they create ''really are'' just piles of unworkable junk, and the particular power they have developed is the ability to make their crazy inventions work. Any attempt to analyze and reproduce the devices prove to be fruitless and show that there is no way they should function in the first place. (Much to the chagrin of the creator of Dr. Travnicek who created Modular Man with the intent of selling armies of humanoid robots to the military.)
*Professor Drummond from the Nick Carter short story ''Nick Carter and the Professor'' from 1902. This story appeared in the reprint anthology Nick Carter, Detective published in 1963 by the MacMillan Company, with an introduction by Robert Clurman. Drummond worked out of Malden, MA and had his underlings steal a body from Mount Auburn in Cambridge. Carter also faced Dr. Jack Quartz.
*Most of the villains in the ''MaximumRide'' series. Often hilariously overdone, as with [[ThoseWackyNazis ter Borcht]], who is a thinly disguised {{Expy}} of Josef Mengele in personality, [[ArnoldSchwarzenegger Arnold Schwarzenegger]] in appearance.
* In EdgarRiceBurroughs's ''[[JohnCarterOfMars The Master Mind of Mars]]'', Ras Thavas. Who actually makes his living selling his skills and doesn't care about the rest of the world.
** In ''A Fighting Man of Mars'', Phor Tak. Originally sane while making his inventions, but losing it after being maltreated and exiled by his jeddak. At first it appears to be {{Revenge}}, but in the end, he reveals he wants to TakeOverTheWorld.
*Garfield Reeves-Stevens' novel Dark Matter features a mad scientist cum serial murderer who actually manages to endow himself with metahuman powers similar to Captain Atom, Doctor Solar, Firestorm, and Doctor Manhattan (in imitation of the latter, he even visits Mars).
*Remo Williams has encountered mad scientists, for example Dr. Judith White, who mutated herself into tiger/homo sapien hybrid.
[[/folder]]

[[folder: Live Action TV ]]

* Jha'Dur on the ''[[BabylonFive Babylon 5]]'' episode "Deathwalker".
* Beakman on ''BeakmansWorld'' had the outward appearance of one, but as this was an EdutainmentShow, most of his science was pretty sound. Most of it.
* Professor Maggie Walsh and Warren Mears on ''BuffyTheVampireSlayer''.
* Parodied on one episode of ''{{Dinosaurs}}'': a scientist on TV gives the "They called me MAD!" speech before unveiling his latest creation, a giant living squash. When his assistant calls him mad, the scientist calmly agrees, adding that what made him seek revenge is that he's ''angry''-mad, not ''insane''-mad.
* John Lumic from the ''DoctorWho'' two-parter "Rise of the Cybermen/The Age of Steel". In addition to being an EvilutionaryBiologist, he explicitly considers himself above law.
** ''DoctorWho'' is ''filled'' with Mad Scientists, ranging from the slightly unhinged, endearing sort to the completely unrepentant, {{Omnicidal Maniac}}s. The best example is, of course, Davros, the creator of the Daleks, who easily conveyed just how twisted he was even without an EvilLaugh.
** Don't forget the Rani!
* Topher from ''{{Dollhouse}}'' and, even more so, [[spoiler: Alpha]].
** Topher is more TheLabRat with delusions of mad scientisthood.
**[[SummerGlau Bennett]] appears to be one of these, too, if the promo material is anything to go by.
*Walter Bishop of ''{{Fringe}}'', most of whose nervous tics and general mental confusion disappeared about the same time he was released from the mental asylum (he claims that they were side effects of the drugs he was taking). Of course, he's still a "fringe scientist", which means he's focused on things like teleportation, astral projection, reanimation, and diseases-that-turn-skin-and-muscle-tissue-translucent.
** Disappeared? What show were you watching?
** Actually, Walter operates under the influence of up to a half-dozen home-brewed mind-altering substances of his own design. So if he seems less twitchy at any given time, it is
because he is taking much better drugs than the generic crap he received in the mental asylum.
*** Possibly one with an alternate-dimension version of Walter who ''doesn't'' dose caterpillars with LSD, wander around the lab with a cow, express a desire to own a two-headed goat and actually ''say'' TheyCalledMeMad.
* Dr. Yes and others on ''GetSmart''.
* ''Series/{{Heroes}}'', Volume 3 [[spoiler:Mohinder Suresh]] crosses this line when the SuperSerum [[TooDumbToLive he's injected himself with]] causes him to become increasingly unstable as the season progresses.
* Daniel Faraday on ''{{Lost}}'', especially the "scatterbrained" part.
* Dr. Bunsen Honeydew of ''TheMuppetShow''.
* Dr. Clayton Forrester on ''MysteryScienceTheatre3000''; his mother later takes up the role.
** Joel also qualifies to some degree. He built smart robots out of ordinary spaceship parts, and his invention exchange concepts are a little... odd.
* ''StargateSG1'' has a woman known to many as the [[ExactlyWhatItSaysOnTheTin Destroyer of Worlds]] for her twisted experiments with genetics and chemistry.
* Degra, Dr. Crell Moset, Dr. Chaotica and numerous other specimens can be spotted on every incarnation of ''StarTrek''.
* Dr. Miguelito Loveless, ''TheWildWildWest''.
* Comic Book Evil, of the sort perpetrated by {{Mad Scientist}}s, is the reason ''TheMiddleMan'' organization exists.
* Phil and Lem from ''BetterOffTed''. And by extension, every scientist who works at [[MegaCorp Veridian Dynamics]].
* For their tv show the Japanese band Arashi spent a great deal of time coming up with such stellar experiments as "How far can you sail a boat made of hay?", "Will wasabi still taste spicy if you hold your nose while eating it?" and "What happens if we have a hurdle race whilst wearing binoculars?" Unsurprisingly these all tended to backfire on them.
* Gaius Baltar is something of a deconstruction as his madness may or may not be messages from the gods, messages that ultimately the key to finding Earth.
[[/folder]]

[[folder: Mythology ]]
* The mythical Greek inventor Daedalus may be regarded as the first MadScientist.
* The god Hephaestus/Vulcan deserves honorable mention for his two mechanical servant girls.
[[/folder]]

[[folder: Tabletop Games ]]
* The original ''[[TheWorldOfDarkness Mage: The Ascension]]'' gameline had the 'Sons of Ether', a "Tradition" of technomantic mad scientists who see their magick as the ultimate form of True Science. Virtual Adepts and Iteration X also fit this mold.
** Then There is the fan made [[GeniusTheTransgression Genius: The Transgression]], which is all about Mad Scientists so crazy that they can create stuff that ''breaks the laws of physics''
*** Well, not so much ''breaks'' the laws of physics as delicately bending them.
*** The Catalysts of Geniuses even relate to five mad scientist stereotypes and quotes:
** '''Grimm'''; [[{{Wrath}} anger]] and vengeance: ''You will pay for what you've done.''
** ''Hoffnung''; vision and hope: ''We won't have these problems when I TakeOverTheWorld!''
** ''Klagen''; loss and sorrow: ''No, you fools! You'll doom us all!''
** ''Neid''; banishment and [[GreenEyedMonster jealousy]]: ''They scoffed at me, they laughed at me, TheyCalledMeMad!''
** ''Staunen''; [[ForScience curiosity]] and amazement: ''Oh, the things I have seen...''
* Fabius Bile of ''{{Warhammer 40000}}''. His lab coat is made out of human flesh. That about sums up his state of mind.
** Magnus the Red, Daemon Primarch of the Thousand Sons, arguably qualifies for this trope, though he's more of a mad wizard. He's got the reckless pursuit of knowledge, megalomania, production of the odd superweapon, and lead an entire legion of super soldiers into daemonic corruption.
** Every Mekboy ever. When they aren't building [[HumongousMecha big stompy idols of Gork and Mork]], they're building chaotic field artillery or welding [[strike: small]] big guns onto bigger guns.
** The [[CargoCult Adeptus Mechanicus]] tend to get like this as you get further up the chain of command, especially with [[GeniusBruiser Masters of the Forge]]- part [[SuperSoldier Space Marine]], part TechnoWizard, all trouble.
* In the ''{{Warhammer}}'' universe, pretty much any Skaven from Clans Skyre, Moulder or Pestilens. They nicely cover all three of the main Mad Scientist archetypes: Moulder are the ''{{Frankenstein}}'' types, stitching together psychotic, uh, ''things'' to make ''even bigger psychotic things''. Pestilens are the disease merchants, mixing together various toxic goops with the eventual goal of making the perfect plague to unleash on the Overworld. Skyre are the engineers, making [[GreenRocks Warpstone]] shooting gatling guns, cannons that fire green lasers, and [[WhatDoYouMeanItsNotAwesome giant armoured hamster wheels that throw off green lightning indiscriminately]]. These three clans then sell their services to all the myriad Warlord ("normal") clans, to aid them in their conquests. For the record, the other "techhologically advanced" races have only just invented gunpowder, and most are still on bows and arrows.
** Although the Dwarfs do have this weird steam powered gyrocopter.
*** Dwarfs tend towards ''sane'' engineering, in that they have this really conservative engineering guild keeping them from going Skaven. While you do get the occasional young maverick, most of those tend to stop being mavericks as soon as they lose their first limb to an explosion.
**** Actually, it's pretty much standard for aspiring Dwarf engineers to [[TheyCalledMeMad get kicked out of the guild]] when they try to invent something new, usually joing the human guild for a while until they refine their prototype to something more reliable and trustworthy- Dwarfs like to maintain their reputation for machines that run like a Swiss watch.
* The Demon Prince Vapula from ''InNomine''. He... stands out a bit from the more traditional Demon Princes.
* MagicTheGathering features Niv-Mizzet, leader of the red/blue Izzet faction in the ''Ravnica'' block. Combines the raw power, volatility, and vanity of a dragon with the intelligence and madness of a MadScientist.
** There have been many Mad Scientists throughout the game, including Momir Vig from the same arc, Yawgmoth (before he got worse), Gatha, and Urza, a rare example of a sympathetic Mad Scientist.
* Mad Science is an arcane background, and the Mad Scientist a standard character archetype, in ''{{Deadlands}}''. It's caused by [[spoiler: demons whispering secrets of future technology into the ears of promising inventors]], which is as good a reason as any to go insane, I guess.
** Its sequel, ''Hell on Earth'', is set in a future where Mad Science brought about the [[ApocalypseHow Apocalypse]]. As a result ([[spoiler: this was the ultimate goal of the demons who caused mad science in the first place, so they stopped 'helping' when it was achieved]]), traditional mad science stopped working, and was replaced with [[TechnoWizard techno-shamanism]] and a more {{Anvilicious}} source of insanity: "gun spirits".
* Given that most D&D settings don't have scientists of any sort, it's up to {{Ravenloft}} to take up slack for the others on this trope. Being a ''Gothic horror'' game-setting, it does so in spades, with golem-crafters (Victor Mordenheim, Emil Bollenbach), BiologicalMashup-makers (Frantisek Markov, Vjorn Horstman), Mind-Raping psychiatrists (Daclaud Heinforth, Celeste d'Honaire-Levode), and Woobie-ish crackpots trying to reconstruct their dead loved ones (too many to list). And that's not counting all the cackling weirdos who'd more properly be classified as Mad ''Necromancers''.

[[/folder]]

[[folder: Videogames ]]

* ''AdvanceWars'' had Lash, a girl genius version of the mad scientist. The reboot ''Days of Ruin'' has Caulder/Stolos, probably the most extreme mad scientist ever. Among his creations are [[spoiler:the games equivalent to nukes, a giant bomber, cloned humans intended to be used as [[SuperSoldier Super Commanders]], and most of all, a virus that kills its host by growing flowers all over it's body]]. He also loves to manipulate people into fighting each other just so he can observe them and views humans as little more than test subjects... [[CloningBlues Including himself]].
* Klungo from the ''Banjo'' games. He's responsible for Gruntilda's Beauty-Stealing Machine and in Grunty's Revenge is hinted that he also created Grunty's monster army. Unique in the fact he also happens to be the TheIgor.
* Dr. Suchong from ''{{Bioshock}}'' is the sinister and detached version, the warped genius behind much ADAM research, including several plasmids, the [[CreepyChild Little Sisters]], and the Big Daddies.
** Not to mention the fact that he was the linchpin behind virtually everything that went wrong in Rapture, including [[spoiler:the protagonist himself]] -- but, at least, he [[spoiler:died an [[HoistByHisOwnPetard ironic death]]...]]
* Busuzima from ''BloodyRoar'' went so far as to freakishly mutate his co-worker Stun to steal his research. Starting as a child who wanted to create a creature that would never die, he's fallen to become a {{Jerkass}} who would sacrifice anybody for money and power. He can also turn into a chameleon and [[IKnowKarate fight quite well]], but (unusually for his occupation) that's a natural part of him.
* ''CityOfHeroes'' and ''City of Villains'' have several of these, not including player character concepts: Dr. Aeon is the foremost example, tapping the energy of a slumbering demon in order to power his city. There's also Vernon von Grun, a MadScientist-In-Training Lab Assistant.
** The Clockwork King ''thinks'' that he's a MadScientist, but he's actually an extremely powerful [[PsychicPowers psychic]] whose creations work because he believes they do.
*** Brutally expanded on in a high level story arc, where an alternate universe version of the Clockwork King has realised his own sanity, and focused enough to ''conquer the entire planet and kill everyone on it''.
** And there's Dr. Vahzilok, obsessed with conquering death, with [[ZombieApocalypse fairly typical results]].
** Don't forget the Council, of which all of The Center's generals are mad scientists (SIX of them!). The lower ranks of the Council are filled with their creations.
** It's mentioned at least once that Arachnos (the Big Bad Organization ruling the isles in which the game takes place), intentionally trains and recruits mad scientists, in order to stay ahead of the mad science game, ensuring their dominance above lesser criminal organizations.
** The Hamidon is the result of a very, very insane [[GaiasVengeance ecoterrorist]] using [[{{Magitek}} science and black magic]] to turn himself into a [[AttackOfThe50FootWhatever giant amoeba]] that threatens to [[TheEndOfTheWorldAsWeKnowIt devour the entire earth]]. The Hamidon is responsible for spawning the faction known as the [[MeaningfulName Devouring Earth]].
* [[MadDoctor The Doctor]] from ''CaveStory'' shows traits of this trope as well.
* ChronoTrigger's Lucca is a rare heroic example.
** ChronoCross has a less heroic version in Luccia.
* Every single villain in the ''CrashBandicoot'' franchise is either a mad scientist (usually with a first name starting with the letter N, which lends itself to {{Punny Name}}s such as Neo Cortex (the usual megalomaniac {{Big Bad}}), N.Gin (the {{Yes Man}} and more recently, {{The Igor}}), Nitrus Brio (a chuckling Frankenstein-like midget), N.Tropy, N.Oxide and N.Trance) or a hideously mutated anthrophomorphic animal created by said mad scientists.
* ''[[{{Crusader}} Doc]]'' tor! ''[[{{Crusader}} Gre]]''gor! ''[[{{Crusader}} Hoff]]''man!
* Mao in ''Disgaea 3''. Despite being the main character, Mao is quite possibly the archetypal mad scientist. Thoughts of experimentation on interesting subjects send him into an excited fit, even if the subject turns out to be himself. The main story ends with [[spoiler:Mao capturing and continually experimenting on the BigBad, instead of killing him.]]
* DeadSpace has two, one [[TheProfessor good]], the other...[[KnightTemplar not]] [[BigBad so]] [[EvilutionaryBiologist much]].
** The first one, Terrance Kyne, while he's gone a bit batty after being thrust into the middle of a ZombieApocalypse, and has a habit of talking to his [[DeadPersonConversation late wife]] ([[spoiler:although that's not a sign of mental illness, it's a manifestation of the Marker]]), he's an ok sort who just wants to help Issac.
** The other is [[MadDoctor Mercer]], who will do [[MoralEventHorizon absoluely nothing]] to endear you to him.
* Bob Page from ''Deus Ex'' certainly fits this trope. Hell, the man has built entire multi-national conglomerates dedicated to such "grey area" pursuits as transgenics, bioweapons, espionage, nanotechnology, and cybernetics; all as part of a XanatosGambit to rule the world.
** Bob Page also employs plenty of other scientists, some of whom are completely ignorant about what they're doing, some of whom were captured and forced to work and some of whom are just completely without morals.
* Dr. Neurosis in BrainDead13, who plays out every MadScientist trope in the book.
* At least three ''DevilMayCry'' villains have been scientists researching, experimenting on and trying to create demons - Arius in the [[DisContinuity ignored title]], Agnus in ''DevilMayCry 4'' and Chen from the second novel. It's debatable as to how "scientific" this line of work is, though, so we could call them Mad Pseudoscientists or something.
* K.Rool from {{Donkey Kong Country}} takes a persona based on this trope in ''Dixie's Double Trouble''.
* Professor Monkey-for-a-Head from the ''EarthwormJim'' games. "Don't make the monkey mad, son!"
* The Master from ''{{Fallout}}'', who beneath a calm, arrogant exterior topped by the reasoning of a WellIntentionedExtremist exhibited a multiple personality disorder and overall emotional frailty.
** The ''Fallout 3'' DLC ''Point Lookout'' gives us [[spoiler:Professor Calvert, a BrainInAJar with a robot filled underground base whose goal is to turn all of Point Lookout's inhabitants into his mind controlled slaves.]]
* ''FinalFantasyIV'' gives us Dr. Lugae, one of Rubicante's servants. He gleefully turned Edge's parents into hideous monsters, and when the party confronts him attacks them with a giant robot named Barnabas before turning into a mechanical skeleton to continue the fray. When the heroes finally reach Rubicante, he actually apologizes for Lugae's actions.
** ''[[CrowningMomentOfAwesome "It was Lugae who made chimaerae of your parents. I shared no hand in his perversities. They shame me, as they grieve you."]]''
* Hojo from ''FinalFantasyVII'' is truly an archetypical MadScientist, right down to his outfit and sociopathic habit of sacrificing a great deal for the sake of scientific discovery (which, in his case, underlies his utter insanity). When you get down to it, Hojo may very well be the leading villain in the game, considering that most of the conflict in the game is indirectly his fault.
** Cid, one of the trademark characters of the ''FinalFantasy'' series, is sometimes portrayed in this light. Examples are in ''FinalFantasyVI'', where, despite working for TheEmpire, he is a sympathetic character, and in ''FinalFantasyXII'', where he is a main villain and fits this trope to a T.
* Dr. Curien in the ''HouseOfTheDead'' series. The third game has little cutscenes that chronicle his transformation from "scientist-trying-to-find-cure-for-sick-son" to "zombie-obsessed-psycho."
* ''Impossible Mission'': Two words: Elvin Atombender.
* The first six members of Organisation XIII in ''KingdomHearts II'' were originally assistants to Ansem the Wise and his research on the Heartless. Vexen keeps up his research.
* Doctor Fred Edison from the PC game ''ManiacMansion'', its sequel ''DayOfTheTentacle'', and the television program arguably based on them. Granted, his desire to take over the world and generally be evil was planted in his head by a purple meteor, but as the sequel shows, even when he's not being controlled, Fred is still a very whacked-out and amoral scientist.
* Dr. Albert Wily from the ''MegaMan'' series; arguably, the heroic Dr. Light as well.
** Wily's so nuts, some of his own ''creations'' are mad scientists, too; most notably, Gravity Man, whose data card quote is taken from Galileo.
** ''MegaMan X'' gives us Serges (who is speculated to be connected to Wily), Dr. Doppler (although he didn't really have a choice...), Gate (see Doopler).
* Dr. Albert Wesker might just outcrazy him. He steals the original virus from James Marcus before killing him, works with another mad scientist in William Birkin to make a better virus, and lures his special forces swat team in to battle mutants created by the virus. Things get mad when he injects himself with a virus, allows himself to be killed and blown up so he comes back superhuman, then as a Agent Smith type works on stealing other viruses, using all manner of spy gear, his own personal secret agent and a private army. Not to mention he's actually a clone. When the company he used to work for is exposed for the virus he was responsible for Wesker gives evidence, essentially making him the hero. And just to top it off he plans to use a virus that would infect the whole world, leaving only a select few who are meant to be worthy as surviving. Oh yeah, after one of the people he tries to kill throws him off a cliff, he kidnaps her and makes her into a brainwashed and crazy superhuman.
* Guildernstern from the ''{{Onimusha}}'' series of videogames, and his successor in the fourth installment Rosencrantz ([[ThemeNaming see a pattern here?]]), both qualify as mad scientists. Guildenstern can't help but experiment with demon and human anatomy to come up with truly horrifying monsters for the protagonist to face. Even in the second game where he is never seen, he is mentioned in many in-game texts as the reason your character has to go through such hell with [[SchizoTech biomechanical demonic constructs]] plaguing him at every other turn.
* The game ''{{Psychonauts}}''. The villain Dr. Loboto has all the trappings of a mad scientist, while using the style of his doubtless-failed career in dentistry.
* Ewei/Wei Queyin from ''RomancingSaGa'' is a [[http://youtube.com/watch?v=kzSghJAxvXE solid example]]. He does not have a lab assistant, however, but does have a CosmicKeystone.
** Also WordOfGod states that he experimented on himself, infusing monster cells into his own, extending his own lifespan, however he is still mortal regardless.
* Dr. Ivo "Eggman" Robotnik from the ''SonicTheHedgehog'' series. He has a recorded IQ of 300 and an almost admirable level of persistence. He is, however, entirely sane, relatively speaking.
** Also Eggman's grandfather, Gerald Robotnik, brilliant scientist who designed a working orbital space colony and dabbled with artificial life forms among other things. He was driven insane after his granddaughter was killed by G.U.N.. The depths of his hatred for the world and his desire to destroy it shocked even Eggman himself.
* Andross in ''StarFox'', who employed several bio-weapons (as in, lifeforms created as weapons) in StarFox ''64'' and ''Command''. The later however somewhat redeems his actions by revealing that [[spoiler: he had been working on a device that would terraform the aptly named planet Venom into a more inhabitable one. Which just happens to be the perfect counter to the new threat, which come from the acidic oceans of the planet]].
* Lemon Browning from SuperRobotWars. While not really 100% evil, she did conduct very mad researches that borders on [[AGodAmI playing God]], such as the premise of W Numbers, which is to create an Artificial Human that is as perfect as possible compared to usual humans. She's also sort of the EvilTwin of [[MsFanservice Excellen Browning]].
** Also from SuperRobotWars, Aguila Setme and Egret Fehu. Both pretty much are similiar to Lemon, except she at least had human decency and AlasPoorVillain. Aguila mind fucks CHILDREN and turns them in living weapons, and figures any psychological scarring her sick experiments inflict can simply be removed with more brainwashing, or retained in some form if it make them fight even better. Egret builds ArtificalHuman Machinery Children, who basically agree with his belief HumansareBastards (not to mention we suck from a biological standpoint), and is willing to kill all of humanity to acheive his end goals.
** Kenzo Kobayashi was one of these (still is to an extent), but performed a HeelFaceTurn in Original Generation (officially, was doing so slowly anyway after he developed a conscience prior)
* The TalesSeries has a few of these.
** From TalesOfDestiny
*** Philia has traits of this
** From TalesOfDestiny 2
*** Harold, good lord Harold
** From TalesOfSymphonia
*** Kvar
*** Rodyle
** From TalesOfTheAbyss
*** Jade (Although his science-y days are done. Now he's just a heroic MagnificentBastard / ColonelBadass.... Until he restarts at the end of the game for a TakeThat moment against the BigBad.)
*** Dist, oh dear god Dist.
** From TalesOfVesperia
*** Rita Mordio
** From TalesOfPhantasia
*** Reison
* Dr. Muto is a protagonist example: His machine [[MikeNelsonDestroyerOfWorlds accidentally destroyed his own planet]] and he spends the game trying to collect the {{MacGuffin}}s required to rebuild everything, aided by the fact that he can transform into various creatures to progress.
* TheMedic and The Engineer of ''TeamFortress2''. The former is a [[ThoseWackyNazis German]] DeadlyDoctor who heals out of convenience rather than anything resembling altruism, while the Engineer is a [[EverythingsBiggerInTexas Texan]] [[OmnidisciplinaryScientist holder of numerous degrees]] GadgeteerGenius who has a great EvilLaugh.
**The Engineer is something of a subversion. EvilLaugh aside, he's probably the sanest character in [[WorldOfHam the game]].
* ''{{Thief}} II: The Metal Age'' features Father Karras of the Mechanists. He's mentioned in the first game as the fellow responsible for Garrett's replacement ocular, but by the second instalment, he's gone completely 'round the bend and is cheerfully intent on bringing about {{The End of the World As We Know It}}. He also has a preoccupation with Garrett...
* Dr. Kranken from ''ViewtifulJoe 2'' fits the trope (like everything else in the games) to a stereotypical T.
* Professor Emma from ''WildArms1'' has shades of this, most notably when she led the team to a secret underground base that none of your teammates knew anything about, although the team [[SquishyWizard spellcaster]] is the princess of the town it's built under.
--->'''Hanpan''': There you go again, with another crazy idea... Isn't this illegal?
--->'''Jack''': Someone stop this crazy professor...
--->'''Emma''': I wasn't sure what I was getting into, so I didn't bother getting a permit.
* {{Xenogears}} has arguable BigBad Krelian, for whom everyone on the planet is a test subject, and, on the heroic side, the decidedly eccentric Dr. [[CombatMedic Citan]] [[GameBreaker Uzuki]]. [[spoiler:His eccentricity is partially ObfuscatinStupidity, as he's actually a spy. A very intelligent spy.]]
* {{Xenosaga}} goes its predecessor one better, giving us an only slightly mad Strangelove {{Expy}} in Sellers, the classic obsessive type with pretensions of [[TheChessmaster chessmastery]] in Dimitri Yuriev, and the tragic and misunderstood type in Joachim Mizrahi. Mizrahi gets extra points for falling to his death while reciting Scripture at the top of his voice.
* The ''Tales of Monkey Island'' game "Launch of the Screaming Narwhal" features the {{Fop}}pish French doctor the Marquis de Singe. (Pronounced by most of the characters like the English word meaning "burn", but "singe" is also French for monkey.) At one point Guybrush asks him why he would build a lightning machine powered by voles and he exclaims, "Science!"
*Professor Von Kriplespac (More commonly known simply as "The Professor") from ConkersBadFurDay qualifies. He created anti-gravity chocolate and an entire army of evil teddy bears, and thought that a squirrel would be a good table leg replacement.
* One of the main player archetypes in ''DwarfFortress''. The kind who builds a 30-storey engine of destruction just so he can have a million streams of magma pouring down onto hapless goblin invaders at once, or constructs a gargantuan bridge just to find out how far you can throw a goblin.
[[/folder]]

[[folder: Webcomics ]]

* ''CaseyAndAndy'' was created with the tagline "mad scientist roommates who periodically die". Both the eponymous mad scientists have, frequently, died, often at each other's hands, and often while indulging in mad science experiments. It doesn't help that one of them dates (a female) Satan, and their neighbour is an extreme WeirdnessMagnet [[spoiler:who is also an international jewel thief]].
* The Russian atomic bomb researcher from ''AtomicRobo''
* ''GirlGenius'' is set in an alternate timeline where "Mad Scientists rule the world. Badly." Some people are born as "Sparks", with Mad Scientific ability as an inheritable trait -- accompanied with a tendency to go into [[UnstoppableRage a berserk, ranting fury]], and a strange charisma to gather [[TheIgor flunkies]] with.
** Mad Scientists seem to actually outnumber sane scientists in this world. Even those without the "Spark" seem a little crazy.
*** Maybe [[FridgeBrilliance they're just acting as scientists are expected to act]].
* ''{{Narbonic}}'' has "going Mad" as an [[ScienceRelatedMemeticDisorder inheritable genetic disorder.]] The main characters are a mad scientist, her hapless lackey, her gun-toting assistant, and a superintelligent gerbil she created.
** Not only is mad scientist Helen B. Narbon a [[CardCarryingVillain Card Carrying Mad Scientist]] but her mother is also.
* Shaenon Garrity, the creator of ''{{Narbonic}}'', now has ''SkinHorse'', which is filled with the transgenetic products of said MadScientist types, including Sweetheart, an intelligent dog who's one of the heroes. Her creator Captain Bram is definitely a mad scientist. He plotted to take over the United States because the A.K.C. wouldn't recognize his genetically-engineered super battle dog as a registrable breed.
* ''AMiracleOfScience'', is set in a future where Mad Science is a [[ScienceRelatedMemeticDisorder memetically-transmitted mental disease]].
* ''[[http://www.nukees.com Nukees]]'' features Gaviscon van Darrin ("I'm not mad, just really disappointed"), Danny Hua (creator of the Giant Robot Ant), and His Royal Highness King Luca, Monarch of the Nuclear Engineering Department of U.C. Berkeley.
* ''UmlautHouse'' and its successor involve several mad scientists, of both good and evil varieties, and even had a Mad Science Convention.
* ''SluggyFreelance'' has Dr. Schlock, time-traveling expert of Inflatable Technology, and Riff, a violently-minded tinkerer. And they're two of the ''good'' guys.
** And let's not forget Dr. Crabtree, who created Y2k incompliant nanites that nearly killed off most of humanity, and turned herself into a nanite cyborg. And Dr. Steve [[spoiler: Hereti]], who claimed to have created Oasis and could control her via a wrist watch. And Dr. ScabMoreaureau, who created "Rock 'Em, Sock 'Em Gas", which forces two DNA strands to battle each other for supremacy to make genetic clean-up a fun game for the kiddies. Did I mention he's one of Santa's Elves? Yeah, Sluggy Freelance is lousy with Mad Scientists.
* ''[[http://www.madaboutu.com Mad About U.]]'' is about a ''college'' for mad scientists.
* ''ElGoonishShive'' has Tedd Verres, a teen MadScientist, and Dr. Germahn, as Stereotypical German Scientist of the 'good, but mad' variety. Tedd also has an EvilCounterpart from a MirrorUniverse, who seems to be determined to kill all of his alternates. Finally, there were the scientists who worked on Project Lycanthrope, only one of whom lived to tell the tale [[spoiler:(Because he was caught for his ''fatal'' mistake before their gruesome consequences applied, oh the irony)]].
** Note that time has somewhat diminished this: most of Tedd's experiments were given a RetCon, and are now either gifts from aliens (the Transformation Ray) or just things he picked up (Jeremy) -- though Tedd was still smart enough to tune/program said items to his liking. Lord Tedd, meanwhile, has become a BrotherChuck.
*** WordOfGod is that Lord Tedd is going to be playing a bigger role in future timelines; and that he's [[NecessarilyEvil not]] [[WellIntentionedExtremist necessarily]] [[HeWhoFightsMonsters as]] [[FakeBoss bad]] as [[VillainWithGoodPublicity previous exposition]] has made him look. Who the real villain is, [[EpilepticTrees is the subject of debate]].
** Dr. Germahn hasn't been seen in a while, but at last sighting he was mixing a tiny bit of HornyScientist with MadScientist (minus the evil part, mind you), creating such things as a drink that makes [[http://www.egscomics.com/egsnp/?date=2005-08-15 sweat temporarily eat clothing]] (he was thinking of joining a gym), [[http://www.egscomics.com/egsnp/?date=2004-09-23 another that turns people into Anthromorphic cows]] (cause seriously, why not?), another that [[http://www.egscomics.com/egsnp/?date=2004-09-02 turns people young]] (he's rather old), and of course, a [[http://www.egscomics.com/?date=2003-08-15 soda that shrinks people.]] All of which he tests on his [[TheDitz hapless]] [[TheIgor assistant]].
*** One of Dr. Germahn lines PERFECTLY defines him as a MadScientist: "This isn't about money, you foolish intern! It's about having cool stuff to play with!"
* ''[[http://www.gpf-comics.com General Protection Fault]]'' has Nick Wellington and Dr. Wisebottom (his uncle), not to mention Nick's evil MirrorUniverse duplicate, Emperor Nick. There has been discussion of an "Inventor's Gene" running in the family.
* ''SchlockMercenary'' has several, most notably Kevyn Andressyn. One particular MadScientist, 'Gav' Bleuel (who is the [[HumanPopsicle cryonically-preserved]] ''author'' of ''Nukees'') accidentally duplicated himself ''millions'' of times over, making himself one of the largest human ethnic groups in the galaxy.
* Jyrras Gianna in ''DanAndMabsFurryAdventures''. Dabbles in mixing science and sorcery (though he is not a wizard himself), invents a 'cosmetic patch' that alters one's appearance, builds hypertech weaponry out of boredom, and accidentally created new life forms ''twice'' (three times, if you count his part in the creation of the Mows). Unlike most mad scientists, he had enough on the ball to make a fortune from his inventions.
**His depiction in the ShowWhithinAShow Spoof Spy Story depeicts him as an actual one. He procdes to subvert and lampshade various tradional tropes used by by Mad Scientist throughout the arc. (Such while havering a base in a volcano, it's dormant (The crater is in fact filled with orange pillows, not lava))
* Jordan Kennedy in ''[[http://www.exploitationnow.com/ Exploitation Now!]]'', an embittered and tragic TeenGenius who is the last survivor of a project to enhance human intelligence to super-human levels. Known for holding countries for ransom with stolen nuclear weapons and an [[KillSat orbital laser]] or two.
*Morgan La Fey, in ''ArthurKingOfTimeAndSpace'' is an amoral sorceress in the baseline arc, but a MadScientist in the Western arc. And in the future arc, she's an amoral scientist ''and'' a Mad Sorceress.
**The same webcomic also applies elements of the MadScientist trope to King Pelles and his daughter Elaine of Carbonek, and their quest to create the ultimate hero of Christianity (Galahad), by merging their line with Lancelot's. The newspost under the strip revealing this plan (and that Elaine is based on Helen Narbon) calls them "[[http://www.arthurkingoftimeandspace.com/1082.htm Mad Theologians]]".
*Most members of the Society of Inventors in ''ScaryGoRound'' are in fact somewhat benevolent mad scientists. Other characters in the series (such as Archie Stanwyck and the monkey-obsessed Dr. Petrescu) are mad scientists pure and simple. Especially Petrescu, who's idea of a mobile phone is a normal landline strapped to a monkeys head.
* Eric, the nerd from ''{{Loserz}}'', [[http://bukucomics.com/loserz/index.php?comicID=85 having a mad scientist moment]].
* Smic, also known as Sir Reginald, is a British mad scientist of neo-victorian style. His antics include, [[http://www.jaydenandcrusader.com/2008/10/06/kill-anteaters/ harnessing the power of sunspots to fill a house with pizza]], [[http://www.jaydenandcrusader.com/2007/11/17/2007-11-17/ defeating an acid monster with his bare hands]] and [[http://www.jaydenandcrusader.com/2008/06/30/page-75/ raising the recently deceased]]
* Molly the Peanut Butter Monster, Galatea the ''Other'' Peanut Butter Monster, and Dean Martin in ''TheInexplicableAdventuresOfBob.'' Poor Dr. Jean Poule would probably qualify as well, with her bizarre pet project which accidentally generated Molly—if not for the fact that Jean is, in many ways, the sanest person in the whole comic, a quality which in her universe is actually a bit of a handicap.
* In ''[=~Flintlocke's Guide to Azeroth~=]'', the group of engineers who constructed the Ultimate Goblin Engineered Weapon.
* MinionsAtWork: Offering [[http://www.minionsatwork.com/2009/02/minions-151-hard-to-swallow.html An early retirement plan with a fresh, minty after-taste!]]
*In the [[http://lagendcomic.com Lagend]] side story, [[http://lagendcomic.com/Extended.php?page=1&chapter=3 Mary Mendele]] the titular character is a mad scientist who is also a nun.
* Florence, a [[PettingZooPeople humanoid wolf]] and a main character of ''{{Freefall}}'' sometimes worries that her creator, Dr. Bowman, isn't entirely on the straight and narrow.
* Mad Dr. Nesbit from {{Supermegatopia}}.
* Exoth from ''{{Irritability}}'' is a professional mad scientist who spends much of his time making things that are either random or actively harmful to those around him.
* {{TalesOfTheQuestor}} has the Artifactor's Guild, the Alchemist's guild and more tellingly, the entire student body of their University.... on a grimmer note, they have the historical figure of Rosad Athair Beither, a biomancer (essentially a biologist/genetic engineer) who was obsessed with the origin of monsters, and ''created'' monstrosities and conducted horrific experiments on helpless victims as part of his "research." More horribly, his discoveries had such shocking implications that the Racconan government put a stay on his execution till he finished compiling his notes.... and there is apparently a secret society of his followers still active in the Sanctuary City underground.
** The most current side-arc introduces a slightly more benevolent version, in the form of a biomancer attempting to gain sponsorship for his toxin-removing plants....
[[/folder]]

[[folder: Web Original ]]
* The titular character of ''[[DrHorriblesSingAlongBlog Dr. Horrible's Sing-Along Blog]]'' is very obviously drawn from this trope's cliches. With a few tweaks.
* Sukebe from ''{{Pokegirls}}'' - in an odd application of the trope, he does succeed in bringing about the Apocalypse... mostly. But it's not compete, and the world got better eventually. Still, he will always be remembered as having 'showed them all', that's for sure.
*A parody of [[FinalFantasyVIII Sorceress Edea]] by [[TheSpoonyExperiment SpoonyOne]] in his review of FinalFantasyVIII ([[http://www.spoonyexperiment.com/2009/02/04/final-fantasy-viii-review-part-8/ Part 8]]). Spoony portraits himself as 'Dr. Insano', a MadScientist who won the 2008 Presidential Election. Even he was surprised to learn that he won even though he used the name 'Dr. Insano' and his running mate is FuManchu.
**And that was just what he did in his FIRST VIDEO APPEARANCE. Think about that, for a minute. He ain't quoted at the top of this page for nothing.
* In the WhateleyUniverse, some 'mad scientist' types (as well as other superpowered people) have the 'madness as a disease' trope. The universe has an illness called Diedrick's Syndrome that only affects some mutants. Due to an imbalance of neurotransmitters, the person can get paranoid, megalomaniac, etc., and that makes the imbalance worse, so things escalate until finally, said character is insanely screaming about destroying the planet because, say, he originally just lost his car keys.
** Whateley MadScientist example: Overclock, who plotted to make a fellow student accidentally kill fellow students in a holographic simulation and drive her permanently insane, all because she ate the last of his favorite breakfast cereal.
* Carina Appelbaum from ''OpenBlue'' of [[ThoseWackyNazis Seran]]'s science corps holds a commission as [[TheCaptain a captain]], allowing her to use a ship to scour the ocean for additional 'test subjects'. She carries a HyperSpaceArsenal of mysterious vials that could contain anything from explosives to poison.
* Adam appears as a parody of a mad scientist in episode 9 of ''MaddisonAtkins''.
* Dr. Griffin from ''{{KateModern}}'' is a former mad scientist.
* [[http://s2b2.livejournal.com/110334.html?view=1613310#t1613310 This]] Shousetsu Bang*Bang fic has a mad scientist as main character, along with his [[SlashFic loyal]] [[EvilMinions minion]], Scarface.

[[/folder]]

[[folder: Western Animation ]]

* Professor Farnsworth on ''{{Futurama}}'' takes this to the lengths of parody and beyond. Case in point:
** "Even '''I''' laughed at me when I proposed the cross-species genetic analyzer, but I guess I showed ''myself!"''
* Professor Frink of ''TheSimpsons'' is a rather more amicable MadScientist, always apologetic when things go wrong with his inventions, and a passion for inventing crazy things like self-aware robots that only scrub floors, auto-diallers with retractable wheels, automatic tap-dancing shoes, buildings that can sprout legs and run away from danger, and hamburger earmuffs.
-->'''Frink:''' ''(as a radio controlled baby-plane with his son in it crashes)'' Oh dear. My wife is going to kill me.
* The Brain of ''PinkyAndTheBrain''.
* Dr Karbunkle in ''BikerMiceFromMars''.
* Dexter, main character of ''DextersLaboratory''. And his [[TheRival rival]] Mandark.
* Dr. Blight on ''CaptainPlanetAndThePlaneteers'' is literally mad. She is pretty much insane and she is a brilliant scientist, and represents unethical scientific research and technology in the wrong hands, though sometimes, she simply causes environmental for the sake of doing so.
* Simon Bar Sinister from ''{{Underdog}}''.
* Dr. Mephesto on ''SouthPark''. The guy's greatest experiment is a FIVE ASSED MONKEY!
-->'''Chef:''' Hey, you're that crazy cracker from up on the hill.
-->'''Mephesto:''' Sir, if making mutant animals spliced with humans is crazy… then… uhhhhh… hmmm… oh, nevermind.
* A fairly large share of the {{Recurring Character}}s on ''KimPossible'', notably major antagonist Doctor Drakken. But hey its not like any of them are a real threat anyway.
* Parodied by ''SheepInTheBigCity'''s Angry Scientist (who becomes especially angry whenever anyone incorrectly refers to him as a mad scientist).
* Professor Norton Nimnul from ''ChipAndDaleRescueRangers''.
* Dr. Weird from ''AquaTeenHungerForce''.
-->'''Dr. Weird:''' Gentlemen! I have created... this thing.
-->'''Steve:''' What is it?
-->'''Dr. Weird:''' I don't know! Stand over here.
-->'''Steve:''' What, over here - hey!
-->'''Dr. Weird:''' It works! [[TheMadHatter I am one can short of a six-pack!]] (EvilLaugh)
* Chrome Dome from ''TheTick''. El Seed and the Breadmaster may also quality for developing formulae that make plants come to life and bread explode, respectively.
* Dr. Bad Vibes from ''C.O.P.S.''
* Megavolt from ''DarkwingDuck''. Likewise Bushroot, who's usually ignored in this capacity, because his "mad science" is botany.
* Dr. Jumba Jookiba from ''LiloAndStitch'' (although he prefers to be called an "[[EvilGenius evil genius]].")
* Dr. Sevarius from ''{{Gargoyles}}'' isn't quite mad so much as he is amoral, but he displays a touch of the theatricality that is the hallmark of the best nutty professors.
** Then again, he is being portrayed by Tim Curry. Go figure.
*** Hmm, TimCurry playing a mad scientist. Now, [[RockyHorrorPictureShow why does that sound so familiar....]]
**** And of Curry and mad scientists, you're [[TheMaskTheAnimatedSeries forgetting]] [[JimmyNeutron ano]][[NicktoonsUnite ther]].
* Dr. Cinnamon J. Scudworth of ''CloneHigh'' certainly qualifies, even though his day job is as a high school principal.
* The Dark Knight always seemed to be neck-deep in mad scientists on ''BatmanTheAnimatedSeries''. Within the first five episodes of the show, he runs afoul of Man-Bat, the Scarecrow, and Poison Ivy, scientists-turned-supercriminals all. Scarecrow actually goes the whole hog with the trope, as his initial appearance features a plot to ruin the university he was fired from and murder all those who called his sanity into question.
**Yes, killing them all will show that you are PERFECTLY sane...
*** Hey, it's not like they'll be saying otherwise.
* ''JohnnyTest'''s older sisters Susan and Mary are both Mad Scientist teenagers. Also their friendly enemy, a.k.a. "Bling Bling Boy".
* The title character of ''InvaderZim'' is a mad scientist himself. In fact, in a script for an incomplete StartOfDarkness episode about him, [[spoiler:Zim was actually a military scientist for his race whose creation, an "Infinite Absorbing Blob" was responsible for killing two of his previous leaders.]]
**Dib and Professor Membrane would arguably qualify as {{Mad Scientist}}s. (Dib, perhaps more so since his inventions revolve around his all-consuming obsession to destroy ZIM, whereas his father's inventions are more geared toward helping humanity. Even the Super Toast.)
* Plankton from ''SpongeBobSquarePants'' shows signs of being this.
* ''TheSpectacularSpiderMan's'' Doctor Octopus is one of these.
* Wheeljack of ''TransformersGeneration1'' is one. Part of his appeal was him convincing the other Autobots that his crackpot inventions were worth something.
* Tarantulus of ''Transformers: BeastWars'' is, if not a mad inventor, certainly crazy enough and scientific enough and treacherous enough to qualify for MadScientist.
** This is actually a case of CharacterDevelopment; in the first season, while he was the Predacon Science Officer, he was characterized more as "that creepy bot who'll eat ''[[ImAHumanitarian anything]]'' he can catch". And even this was AdaptationDisplacement- in the original toylines, he was a (still cannibalistic) ''ninja warrior''.
* ''TransformersAnimated'' has Prometheus Black. He started out messing around with biochemical enhancements to try and beat out Professor Sumdac's robotics industry, but after a lab accident changed him into the supervillain Meltdown he went into full vengeful mad science mode. The chemical warfare specialist Oil Slick might also count, although outside the fact that he's a ninja who developed the Transformer equivalent of ebola not much is known about him.
* Dr. [[strike:Quest]] Venture on ''TheVentureBrothers'', although his lack of ambitions and general ineptitude mean that he comes up with far fewer superweapons and far more get-rich-quick schemes than most of his ilk. Other M.S.'s in the Ventureverse include Pete White and Master Billy Quizboy, Jonas Venture Jr., Otaku Senzuri from the lost pilot, Professor Impossible, Mike Sorayama, Dr. Septapus, Baron Ünderbheit (implied), and Phantom Limb ([[strike:implied]] confirmed, as part of his backstory)
* One episode of ''InspectorGadget'' features the [[FunWithAcronyms M.A.D.]] Scientist - that is, a scientist that works for M.A.D. However, he gets [[BerserkButton really, really peeved when someone calls him a mad scientist]], screaming, "I'M NOT MAD!!!"
** ''"I'm not '''MAD!''' I'm '''Dr. Focus!'''"'' *gets arrested* ''"Now I'm '''really''' mad!"''
*** ''[[SheepInTheBigCity I am an ANGRY scientist!]]''
** The 1999 feature film has Dr. Artemus Bradford and his daughter, Brenda, both of whom designed the title cyborg. The 2003 sequel has Baxter, who could ''possibly'' qualify...
* Doctor Two Brains in ''WordGirl''
* Dr. Doofenschmirtz on ''[[PhineasAndFerb Phineas and Ferb]]''
** Phineas and Ferb themselves actually. They ''do'' build things like city-spanning roller coasters, time machines and space ships after all, not to mention entire ''landscapes'' in their backyard. But they are very mellow for mad scientists, I'll admit.
* ''TheTick'' has several: Brain Child, Profewssor chromedome and, a more benevolent version, Dr. Tungtung.
* Heloise from ''JimmyTwoShoes'' is this. Despite being a small, petite girl; she is very intelligent and sadistic as she makes inventions for Misery, Inc. that would spread misery to her town and also likes to destroy things for fun. She does have a soft side though as she has feelings for Jimmy buts treats everyone else with disrespect, even her own boss.
* Recombo from ''A.T.O.M''
-->'''Recombo''': My collegues laughed and called me Recombo. They said it couldn't be done. But I shall prove them all wrong. Back home, people called me mad.
-->'''King''': Mad? I was thinking more "total wacko"!
* Dr. Frankenollie in the 1995 [[ClassicDisneyShorts Mickey Mouse]] short, "Runaway Brain".

[[/folder]]

[[folder: Music ]]

* [[DoctorSteel Dr. Steel]] is a steampunk themed industrial musician whose look consists of a shaved head, pointy beard, vintage welding goggles and a mad scientist lab coat.
* The ''Abney Park'' song "The Secret Life of Dr Calgori" is about a MadScientist.
* The [[TheyMightBeGiants Mono Puff]] song "Poison Flowers" is about a young would-be mad scientist lamenting the beginning of the school year as he will no longer have time to build bombs and [[DeathRay death rays]], or to write manifestos.
* JonathanCoulton has at least two: "The Future Soon", about a socially rejected nerd who dreams of becoming a mad scientist in order to get revenge and conquer the world. The other is "Skullcrusher Mountain", which is from the point of view of a mad scientist talking to a woman that his [[TheIgor deformed assisstant]] had kidnapped for him to woo.
** In particular, "Skullcrusher Mountain" is notable for for a line that flirts dangerously with CrowningMomentOfAwesome:
--> "''I made this half pony, half monkey monster to please you,''
--> ''But I get the feeling that you don't like it. What's with all the screaming?''
--> ''You like ponies. You like monkeys. Maybe you don't like monsters so much.''
--> ''Maybe I used too many monkeys.''
--> ''Isn't it enough to know that I ruined a pony making a gift for you?''"

[[/folder]]

[[folder: Real Life ]]

* No report on mad science is complete without the man who might have given creation to the whole trope; NikolaTesla, and his [[http://en.wikipedia.org/wiki/Nicola_Tesla#Directed-energy_weapon Teleforce Death Ray]]. If that's not mad science, this editor doesn't know what is.
** How about harnessing the world's biggest waterfall to power an entire city, producing 150-foot lightning bolts from his ominous mountain laboratory in Colorado, and plotting to broadcast free power to the world from the [[http://en.wikipedia.org/wiki/Wardenclyffe_Tower Wardenclyffe Tower]]?
*** Or, alternatively, how about that he had OCD and synesthesia, had flashbacks to his brother's death whenever he was stressed, and, in his later years, would talk to pigeons and mail letters to Samuel Clemens...who'd been dead for decades? He was definitely a psychologically-troubled member of the science profession, even if he hadn't been a MadScientist.
* Albert Einstein and the German nuclear physicists heavily influenced early {{Mad Scientist}}s like Rotwang in the late 1920s. Crucial to the popularity of these "eccentric German physicists" was how they rehabilitated the image of scientists as {{Spock}}ian pacifists in the wake of WWI, at a time when both war and Germans were intensely unpopular. (Einstein, with his characteristic wild hairdo, became the first scientific superstar and the first [[ProudToBeAGeek Popular Geek]], helping spawn the concept of a {{Reluctant Mad Scientist}} whose inventions are inevitably misused.)
* Nazi scientist [[http://en.wikipedia.org/wiki/Josef_Mengele Josef Mengele]], AKA "the Angel of Death". When this editor first saw his name, he thought it was pronounced "Mangle". Given what he did to the death camp prisoners, that wouldn't have been too much of a stretch.
** [[spoiler:[[EyeScream Butterfly specimen eyeballs]].]]
** [[http://www.dailymail.co.uk/news/worldnews/article-1126504/The-Twins-Brazil-Did-Nazi-doctor-Mengele--Angel-Death--cause-twin-surge-South-American-town.html And he actually succeeded!]]
** In a similar vein, the Japanese scientists who performed experiments on [=POWs=] during the war that makes one wonder if they were trading notes with Mengele at the time. Assuming this isn't just baseless propaganda.
**[[http://en.wikipedia.org/wiki/Unit_731 It was all too real]]
* Austrian-American psychiatrist [[http://en.wikipedia.org/wiki/Wilhelm_Reich Wilhelm Reich]], whose work on human sexuality led him to "discover" Orgone Energy, an omnipresent cosmic lifeforce that was generated (among other things) by orgasm. He sold Orgone Accumulators and even built Orgone-powered "Cloudbusters" which could supposedly make it rain, and ended up being shut down by the Food And Drug Administration for selling lunatic medical devices that didn't work.
** Another version of the story has government agents smashing his laboratory and burning his books because the effectiveness of his work offended the country's puritanical values.
* Aforementioned webcomic ''CaseyAndAndy'' twice had the "Casey And Andy Mad Science Award" for examples of Mad Science in real life. Both times, NASA won: in [[http://www.galactanet.com/comic/view.php?strip=382 2004]] for the [[http://en.wikipedia.org/wiki/Genesis_spacecraft Genesis Probe]] and again in [[http://www.galactanet.com/comic/view.php?strip=508 2005]] for the [[http://en.wikipedia.org/wiki/Deep_Impact_space_mission Deep Impact space mission]].
* Thomas Edison - often portrayed in popular fiction as an evil mad scientist - not because of his scientific skills, but because of his vicious business acumen.
** Well, that, and because of his probable cocaine addiction, probable sociopathy, and certain theft of the scientific inventions of everyone around him.
*** He may also be responsible for the above reputation of NikolaTesla, whom he stole a number of patents from.
* DARPA, the US Government's official program to fund Mad Science. Their only mission is "radical innovation". They fund all sorts of seemingly off the wall projects. Among their successes are night-vision goggles, GPS, and a little thing called the Internet... oh, and funding a little thing called the [[http://www.darpa.mil/grandchallenge/index.asp DARPA Challenge]], for self-driving cars.
* There is a real life psychological diagnosis known as 'Mad Scientist Syndrome,' so named because it tends to be a case of actually believing ''(some wacky event)'' such as alien invasion, or collapse of the world economy will "Show them all that I was right!"
* Yet another article from ''{{Cracked}}'' about the [[ScienceIsBad dangers of science]] [[http://www.cracked.com/article_17039_9-real-life-mad-scientists.html here]]. Surprisingly, Josef Mengele didn't get mentioned. Perhaps the [[EvenEvilHasStandards Cracked writers didn't want to dedicate an entry]] to a guy whose idea of "science" was torturing helpless prisoners for kicks.
* Heston Blumenthal specialises in using scientific study to create tastier food, his restaurant is currently number two in the world. A quick look at the menu will tell you why he's earnt a place of honour on this list.
* What about mad ''psychologist'' [[http://en.wikipedia.org/wiki/Milgram_experiment Stanley Milgram]]?
[[/folder]]
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