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[[quoteright:310:[[Franchise/StarWars http://static.tvtropes.org/pmwiki/pub/images/friends3_3180.jpg]]]]
[[caption-width-right:310:"You were my ''brother'', Anakin! [[PlatonicDeclarationOfLove I LOVED YOU!]]"]]

->'''Captain America:''' I'm sorry, Tony. But he's my friend.\\
'''Iron Man:''' So was I.
-->-- ''Film/CaptainAmericaCivilWar''

Our TrueCompanions, BadassCrew, FiveManBand - whatever - are pretty close. They share a tight relationship, trust and protect each other, would die for each other, if it might be necessary.

Only, what's this? One or several members of TheTeam [[MyGreatestFailure make(s) a mistake or the wrong call]].
[[FaceHeelTurn Or they just become evil for some reason.]]

The reasons might vary, but bottom line is, the once tight bond between the character(s) in question and their former friend(s) is severely damaged, if not completely broken. Instead of love and sympathy, at least one of them feels aversion, distrust, and/or disdain for the other(s), if not outright hatred depending on the severity of what the character has done. Whether they start actively fighting each other or simply share a broken bond and avoid each other will vary, but since things sometimes don't work out the way they are supposed to, they can't reconcile by the end of the episode.

In contrast to a member being PutOnABus (which doesn't necessarily mean these two tropes can't coincide), this trope focuses on the extraction of a character from their usual environment, due to aversion, distrust or a misunderstanding. However, the character is being kept as a part of the story, which is what differs this from simply being PutOnABus - the extracted character is ''not'' being dropped by the writers.
This situation might eventually be resolved by things slowly [[HesBack getting back]] [[StatusQuoIsGod to normal]] or [[DownerEnding it doesn't]].

Might trigger a BeardOfSorrow, TenMinuteRetirement, FaceHeelTurn, HeelFaceTurn, a [[TookALevelInBadass degree in badassery]] or a DespairEventHorizon. [[BetrayalTropes The list goes on and on.]] Can be revealed via FormerFriendsPhoto.

Contrast with HeelFaceTurn. Compare with AchillesInHisTent, DeusExitMachina, MyGreatestFailure, GreyAndGrayMorality and JumpingOffTheSlipperySlope, EvilFormerFriend. See also CainAndAbel, when the former friends in question were either siblings, or were childhood friends who grew up with each other prior to their falling out. For the inversion, see also FireForgedFriends: enemies-turned-allies.

The song by the Dandy Warhols is the {{Trope Namer|s}}, it [[RealSongThemeTune being the theme]] from ''Series/VeronicaMars'' kinda figures.



[[folder:Anime & Manga]]
* ''Manga/{{X1999}}'':
** Arashi Kishu. In order to spare her lover Sorata from his obligation to sacrifice himself for her, she joins the Dragons of Earth to bypass fate. She battles her former Dragons of Heaven friends and eventually [[SelfFulfillingProphecy triggers said prophecy]] with her FaceHeelTurn. In the anime, [[spoiler: Sorata dies anyway in her arms, but manages to make her return to the Dragons of Heaven.]] In the manga, by all appearances, [[spoiler: Arashi ends up BrainwashedAndCrazy at the hands of Hinoto's SuperpoweredEvilSide. With the same result, fighting for the Dragons of Earth. ]]
** More importantly, [[spoiler:Kamui and Fuma. They were best friends as children, and destined to be on opposite sides of the battle for the future of mankind. Whichever side Kamui chose, Fuma would automatically take the empty seat on the opposite side as a substitute "Kamui".]]
* Ash Ketchum and Gary Oak of ''Anime/{{Pokemon}}'' fame. They were good friends and neighbors when they were very young. It's explained that they fought over a Poke Ball they found and broke it, and stopped being friends over it. [[spoiler: It turns out each kept his half of the Poke Ball, and they are on better terms again.]]
* ''Manga/{{Berserk}}'': Guts and Griffith were close when they fought together in the Band of the Hawk during the Hundred Years' War. Guts deeply admired Griffith for the ambition of his dreams, and Griffith held Guts in greatest confidence by sharing parts of his personality that he would never show to his other followers. Things started to fall apart when Guts overheard Griffith saying he did not consider any of his followers "friends", as to him a friend was someone who would pursue a dream even if it meant opposing him. Guts took that as his cue to leave (so as to be able to stand next to Griffith as an equal). This led to Griffith making his career-ending TragicMistake. By the time Guts returned and helped the Hawks rescue Griffith, he all but despised Guts, using his hatred and despair to trigger the Eclipse and [[MoralEventHorizon sacrifice his comrades before doing horrible things to Guts and Casca both as his first act upon becoming a demon god]]. From then on, Guts saw Griffith as his hated ArchNemesis, while Griffith claimed to feel ''[[LackOfEmpathy nothing]]'' for Guts or anyone else.
* In ''Anime/NeonGenesisEvangelion'', Ritsuko and Misato had been friends since college, but the events of the series caused rifts between the two, leading to frequent (and sometimes physically violent) arguments about how to handle situations which could endanger the pilots, and it doesn't help matters that Misato slowly came to realize just how much Ritsuko kept her in the dark about NERV's rather disturbing secrets. In the latter part of the series their relationship constantly teetered on the edge of fully turning into this trope, and it became pretty clear that Misato only stayed on speaking terms with Ritsuko because there weren't too many others around to talk to any more. [[spoiler:What little that remained of their old friendship finally ends in Episode 23, as Risuko reveals the truth about Rei and destroys the Rei clones.]]
* ''Manga/{{Naruto}}'':
** Pretty much the whole point of Part II. Sasuke Uchiha is the patron saint of this. Even his new allies who were ready to give their lives for him were quickly discarded. What's interesting in this case is that Naruto's devotion to saving Sasuke - in one form or another - actually causes breaks between him and most of ''his'' friends, who think Sasuke is an [[ChronicBackstabbingDisorder evil back-stabbing bastard]] who needs to die, when they don't know how Sasuke came to truly be that way, when Naruto does, courtesy of Tobi. So essentially Sasuke has instigated a chain reaction of this trope.
** Even before that, we have Ino Yamanaka and Sakura Haruno stop being friends because they are competing over Sasuke (who doesn't much care for either one of them). They become friends again [[DesignatedGirlFight after fighting each other]] (which, at least to Sakura, was more about proving herself equal to Ino, whom she had held in high regard ever since she met her, than about Sasuke), but do still [[ContinuityNod quarrel over Sasuke from time to time.]]
** Jiraiya and Tsunade with Orochimaru. Jiraiya confronts Orochimaru during his escape from Konoha, and reminds them that the Sannin were friends since their team was formed when they were ''five years old'', but Orochimaru mocks his efforts.
** Oh, you can only imagine [[BrokenPedestal the look on]] [[spoiler:Kakashi Hatake]]'s face when it turned out that [[spoiler:Tobi, [[BigBad Public Enemy #1]] and [[TheHeavy the catalyst for nearly everything that's gone wrong in the verse]], was actually a NotQuiteDead '''Obito Uchiha'''.]] It doesn't help that [[spoiler:Kakashi was forced to kill Rin, [[LoveMakesYouEvil driving an onlooking Obito off of the deep end]].]] In spite of this, it seems that [[spoiler:Obito doesn't blame Kakashi for Rin's death, instead sticking by [[StrawNihilist his belief]] that the ''Naruto'' world is a CrapsackWorld; it could be argued that Obito's AssimilationPlot goal of creating "a world where heroes don't have to make pitiful excuses in front of graves" is being done for not only Rin's sake, but Kakashi's as well.]] It later turns out that Kakashi didn't [[spoiler:kill Rin. [[SuicideByCop She committed suicide by jumping in front of his attack.]] The Mist ninja had turned her into the Three Tails' host in the hopes of her becoming a TragicMonster and killing her village, so Rin enacted an HeroicSacrifice to ruin their plans and save her loved ones. Obito brushes it off due to his insanity-induced beliefs.]]
** In ''Naruto'', this goes way back to the First Hokage and Madara Uchiha. The latter, who is the BiggerBad of the series and a ManipulativeBastard while being dead, had fantasized as a kid with the former about creating a place where children wouldn't be sent to die in war. As an adult, after temporarily giving his old dream a shot, he named the Hidden Leaf Village.
** In the pilot, Saburo and Kuroda, two fellow artists, were friends until the latter took over the former's job as head of the Council on Cultural Advancement, which resulted in [[KlingonPromotion Saburo stabbing Kuroda in an attempt to get the job back]]. Kuroda survived, but became cynical, bitter and unwilling to trust others. Saburo, [[MyGodWhatHaveIDone feeling guilty]] and apparently wanting to be friends again, painted his last work, "Symbol," as a symbol of trust and friendship, before [[DrivenToSuicide killing himself]].
* ''Anime/CodeGeass'' Suzaku Kururugi and Lelouch Lamperouge were friends in childhood but separated during Britannia's invasion of Japan. When they met as young adults, they were on opposite sides of Japan's war for independence, although it takes them a while to realize this. Things only get worse when [[spoiler:Lelouch accidentally Geasses Euphemia, the woman Suzaku loved, into committing genocide, and then has to kill her himself]].
* Happens to Yomi and Kagura in ''Anime/GaReiZero'', the prequel anime to the manga. Yomi's fall is pretty heartbreaking, and they only further make it more painful [[spoiler: by the BigBad who unleashes an attack on Yomi which doesn't kill her, but severs her voicebox and nerves so she's only barely able to communicate by using her finger, and can't speak. The scene where she's trying to cry in the hospital after her fiance is forced to break off their engagement is particularly [[TearJerker heartbreaking]].]]
* Miaka and Yui in ''Manga/FushigiYuugi''. Yui becomes Miaka's worst enemy after Nakago manipulates her into believing that Miaka doesn't care about her or her feelings for Tamahome.
* A major force of tension in ''Anime/MobileSuitGundamSeed'' is the fact that the two protagonists, Kira and Athrun, are best friends who have somehow wound up on opposite sides of a war. There is a great deal of introspection between the two of them about what this means to their friendship, how each other have changed, and why are they really fighting anyway? [[spoiler:Eventually they both decide to TakeAThirdOption and wind up as part of the Three Ships Alliance, on the same side once again.]]
* The second-gen story of ''Anime/MobileSuitGundamAGE'' revolves around Asemu Asuno and Zeheart Galette, who befriended each other when Zeheart (a Vagan) went undercover in Asemu's high school to find the Gundam (which is the Asuno family's raison d'etre). Soon enough, Zeheart reveals himself and returns to his side. He and Asemu are really conflicted about fighting each other, end up working together to prevent a ColonyDrop, [[spoiler:but in the third generation Zeheart goes over the edge and only reconciles with Asemu during a fatal duel that Asemu wins]]. An [=OVA=], ''Memory of Eden'', was made to further expand the Asemu--Zeheart story.
* [[Manga/MuhyoAndRoji Muhyo]] and Yoichi with Enchu. The three were close friends in the academy, but Muhyo and Enchu were considered for the position of Executor; Enchu was desperate to get the position so that he could support his sick mother while Muhyo didn't want it. Enchu losing his mother and the position in quick succession was his StartOfDarkness, as he became obsessed with revenge against Muhyo.
** Page and Tomas used to be friends before Tomas's evil nature became apparent.
* [[spoiler:Mariko and Aya]] in the anime of ''Manga/OniisamaE''. [[spoiler:They got along in junior-high, but one day Aya threw Mariko under the bus in a school competition, and things never were the same from then on.]]
* In ''Anime/MaiHime'', Shiho and Mai got along well early on in the series, with Shiho asking Mai to [[ShipperOnDeck root for her attempts to win Yuuichi over]]. Midway through the show, however, Yuuichi tells Mai he has feelings for her with Shiho in earshot, and Shiho accuses Mai of lying to her [[spoiler:and tries to kill her when her Hime powers awaken, even going so far as to ''kill Mai's younger brother out of spite'']].
* In ''Webcomic/AxisPowersHetalia'' we have America and England. Theirs is an interesting case, because even though America betrays England, it's done for political reasons, not because he hates him, and England is [[BreakTheCutie broken]] by it, but can't bring himself to kill him because he still loves him. Then, after hundreds of years they start to mend their bond. The [[{{Shipping}} shippers]] are not shy about what they think of all this.
** In the webcomic form of the series, there was also [[http://hetalia.livejournal.com/2977183.html Japan and China.]] China raised Japan as his little brother, only for Japan to break away by attacking China with a katana.
* In ''Manga/FistOfTheNorthStar'', a lot of the ManlyTears shed when Kenshiro and Raoh fight are because they both know that they can only win by killing their brother. Even when Kenshiro is ultimately victorious, he chooses to remember Raoh as the beloved brother he used to be.
** The series basically began on this trope. The StarterVillain of the series was Shin, a former friend of Kenshiro's, who in a mix of insanity and vying for Ken's fiancee Yuria, gave Kenshiro his well-known seven scars on his chest, then strong-armed Yuria into his palace, under threat of killing Kenshiro. Later, Rei faces off against arch-enemy Yuda - both of whom trained in the art of ''Nanto Seiken'' together.
* The third drama CD for ''Anime/PuellaMagiMadokaMagica'' showed that Mami and Kyouko, who were shown together in the series itself for all of two scenes ([[spoiler:either in alternate timelines or after Madoka erased all witches]]) used to be close in something like a SempaiKohai relationship before [[PaterFamilicide a very personal tragedy befell Kyouko]], which soured her personality so much she left. In ''[[Manga/PuellaMagiMadokaMagicaTheDifferentStory The Different Story]]'', Mami and Kyouko do interact, as [[spoiler:Mami lived longer than in canon]], and things are largely awkward because of their differences, although they do still care for each other.
--> '''Kyoko:''' To me you're Mami Tomoe... [[spoiler:the only... family I got left!]]
** This is also true of [[spoiler:Homura and every single one of the main characters, due to the time loops]]. As was alluded to in the manga, and due to extreme PTSD after all that she had to suffer through, she is rather hostile toward and pretty much can't stand Mami and Sayaka, due to both of them [[spoiler:being the people most frequently responsible for driving Madoka into contracting with Kyubey]]. It's at the point where she doesn't even try cooperating with them and rejects Mami's overtures during their first few encounters, though the events of Rebellion indicate that there are still some residual feelings there, as [[spoiler:Homura can't bring herself to shoot a 'defenseless' Mami's soul gem during their fight]].
* This is the relationship between [[spoiler:Jacques Durant and General Henri Guisan]] in Manga/HonooNoAlpenRose. [[spoiler:Ever since childhood, they were VitriolicBestBuds: always squabbling, but always by each other's sides. Until they disagreed ''horribly'' about the subject of Durant's daughter Helene's ArrangedMarriage: Guisan not only opposed to have the girl not choose her future husband, but he helped Helene [[RunawayBride escape from the engagement]]. Durant blew up at him when he found out, and they cut each other off. And since few years later the Durants fell in the hands of Toulonchamp the ArmsDealer, Guisan [[MyGreatestFailure cannot forgive himself]] for not having been there for his once best friend.]]
* Fushimi and Yata of ''Anime/ProjectK'' were once extremely close best friends until joining up with HOMRA. After that Fushimi became increasingly uncomfortable in his new surroundings and the fact that Yata didn't notice did little to help. Eventually his frustration and [[GreenEyedMonster jealousy]] of Yata's new found friends lead him to leave HOMRA and completely destroy his relationship with Yata in the process. Now the two of them do nothing but fight if they so much as see each other, though it's made very obvious that it's not really what either of them wants.
* ''Manga/FairyTail'' and its sidestory ''Fairy Tail Zero'' reveals that Mavis Vermillion, Fairy Tail's first Guildmaster, and [[spoiler:Black Mage Zeref]] were friends once. Mavis was the first person to show the latter kindness in a long time, and he was so moved that he taught her and her friends magic. In the present day, [[spoiler:Black Mage Zeref]] has succumbed to the negative feelings festering in his heart for centuries and has decided to wipe out humanity. Mavis seems to still feel sympathy for him, but does not hesitate to respond to his threat with a DeathGlare and a threat of her own that Fairy Tail will be the ones to wipe him out. As it turns out, the situation is a lot more complicated than orginally shown. [[spoiler:Mavis and Zeref were not just friends -- they were ''lovers''. However, it was Mavis's death that drove Zeref into the darkness. While Mavis still clearly loves him and empathizes with his situation, she also recognizes that he must be stopped and doesn't hesitate in aiding Fairy Tail in opposing him]].
** There's something of a three-way version of this between Erza, Jellal and their fellow slaves at the Tower of Heaven. After they managed to overthrow their captors, Erza saved Jellal, but learned that he'd been brainwashed into wanting to resurrect Zeref.[[note]]He's actually not dead, but that's beside the point here.[[/note]] Jellal allows Erza to leave, but does so while threatening to kill their other friends if she tries to do anything to stop him, while simultaneously deceiving the others into thinking she betrayed them by destroying their escape ship. Years later, Jellal finishes building the tower and has his other friends kidnap Erza to use her as a sacrifice, but she manages to get them to see the truth, and Simon sacrifices himself to save Erza. Now, the situation's reversed, with Erza reconciling with her friends and forgiving Jellal after seeing him [[TheAtoner work to atone for his crimes]], while her old friend Millianna teams up with Simon's younger sister Kagura to get revenge on Jellal.
* Takatsuki and Nitori become friends in ''Manga/WanderingSon'' become friends at the start and grow into PlatonicLifePartners over the course of the series. They're best friends and know each other better than anyone else. However this perfect friendship starts dying when they go to separate high schools. Eventually it comes to the point where they barely interact anymore and Takatsuki is surprised by how grown up Nitori has become.
* ''Anime/VividStrike'': Fuka and Rinne grew up in an orphanage together, but Rinne's adoption by a rich family made her cold and aloof (this wasn't the actual reason for the change, but Fuka was under the impression that it was). This led to their falling out about a year before the story picks up when Fuka confronted Rinne about her treatment of one of her opponents in a martial arts match. What makes this notable is that it is a rare occasion in the entire ''Franchise/LyricalNanoha'' franchise (which runs on ThePowerOfFriendship and people being HappilyAdopted) that a friendship is shown to fall apart.
** In ''Anime/MagicalGirlLyricalNanohaStrikers'', Regius Gaiz and Zest were two friends in the TSAB's Ground Forces who were frustrated with a lack of resources available to their branch of the Bureau, so Regius decided to work his way up the ranks and do something about it. Unfortunately, Regius became increasingly corrupt in the process, as well as complicit with the TSAB's darker side. After Zest and most of his subordinates were killed during an attack on [[BigBad Jail]] [[MadScientist Scaglietti's]] base, Zest's clone, who had all the original's memories, sought Regius out for answers as to why he became the person he is today. Their friendship never recovered, but Zest was shocked when Regius died at the hands of Due.
* From what's seen in flashbacks, Tohru and Elma from ''Manga/MissKobayashisDragonMaid'' used to be rather close and traveled together for several decades. By the time the story starts, they are fierce rivals who hate each other due to problems caused by Elma's gluttony. That said, Kobayashi is convinced that they're still friends ([[VitriolicBestBuds just a different kind]]) and the first chapter of Elma's SpinOff reveals that she wishes to rekindle their friendship. [[spoiler:They manage to mend their friendship in chapter 64.]]

[[folder:Comic Books]]
* In the New 52, ComicBook/{{Aquaman}} and his brother Orm (Ocean Master), are portrayed as having been very close as teenagers, and when Arthur left the throne, Orm begrudgingly took his place. The relationship deteriorated when Orm attacked the surface world, forcing the Justice League into action, thus forcing Arthur to pick a side (he was talking both sides down). Afterwards, once Orm is imprisoned, they still don't particularly hate each other, but it's just the way it has to be.
* Depending on the mythos of that universe -- and DependingOnTheWriter -- Charles Xavier and Erik Lensherr ([[ComicBook/XMen Professor X and Magneto]], respectively) started out as best friends and bosom buddies, until they broke off because of differing opinions (Charles with the opinion that mutants and humanity are not enemies and Erik believing they are with mutants poised to become the dominant force).
** In at least ''one'' universe, the 'bosom buddies' business caused (or at least helped) both of their respective marriages to break up. This has not helped the people who protest the HoYay between the two ''at all''.
** The Juggernaut and Black Tom Cassidy, thanks to Juggy's HeelFaceTurn.
** Colossus and Magik. Especially after he sacrificed everything (including his humanity and the love of Kitty Pryde) to save her from evil by taking on the power of Juggernaut only to find that she encouraged him to become the Juggernaut because he still loved her and she wanted to show him what it was like being damned so he could understand her. At the end of ''ComicBook/AvengersVsXMen'', Peter told Illana, "If I ever see you again, I will kill you." They have since made amends and are back to being a family.
** ComicBook/{{Wolverine}} and ComicBook/{{Sabretooth}}, for apparently [[WeAreAsMayflies over a hundred years]]. But then Wolvie got Creed's girlfriend killed, taking away his happy ending, and Creed swore to dedicate his life to making sure Logan would never get one of his own.
* ''Franchise/SpiderMan'': Peter Parker and Harry Osborn. Their rivalry took place in the aftermath of the death of the original Green Goblin, Harry's father, and led to Harry going crazy and becoming the second Green Goblin. That a boobytrap set for Peter almost killed Harry's ex-girlfriend Mary Jane probably was seen by him as a positive side-effect.
* ''{{Deadpool}}'' is going through this with Emily Preston currently. When she was killed on a mission, her consciousness was stored within Deadpool until she could get a new body, which is where their bond really started to form. Deadpool became very attached to her, and sub-consciously didn't want her to leave. After she goes into her robot body, she awakens to see that Deadpool has left. She's told he ran off, and they theorize he did such because he was upset about losing her after everything else he'd been through, and embarrassed that he could have hurt her. Throughout vol 3, they were very close, with Preston adopting Wade's daughter, Ellie. Once vol 4 started, things became more strained with them. As time wore on, Deadpool finds himself on the wrong side of a war in {{ComicBook/Secret Empire}}. [[spoiler: He ends up killing SHIELD agent, Phil Coulson -on order from Captain America, who's been cosmic-cubed into a Hydra agent. The recent chapter shows a flashback where Preston and Deadpool are heading to Coulson's safe-house to find him. Preston, unaware of what happened, asks Wade why he needed to see Coulson the other night. Wade lies about the reason, and continues to lie and play dumb so that Preston doesn't know what he did. But, she founds out and punches Wade, telling him that Ellie also loved Coulson. Preston gives Wade a brutal beating and says she thought up a way to kill him due to him not being trustworthy, given his weak-mind -which she felt someone may control at some point. Deadpool blows them both up with a grenade and destroys Preston's LMD body. Before being destroyed, she tells Wade he will burn in Hell. Wade sadly agrees and rips out her power core. He stares down at her body sadly before boxing up the parts and shipping her somewhere.]] Preston admits to hating Wade in 2099, but also reveals that she forgave him because hatred destroys a person. So their friendship is restored sometime in the future, but it's broken at this point.
* Franchise/{{Superman}}:
** In the [[UsefulNotes/TheSilverAgeOfComicBooks Silver]] and [[UsefulNotes/TheBronzeAgeOfComicBooks Bronze Ages,]] Franchise/{{Superman}} and ComicBook/LexLuthor were friends when they were young. Then a lab accident occurred, which Comicbook/{{Superboy}} saved Lex from. Lex blamed Superboy, and the rest is history.
** In ''Comicbook/SupermanVsTheAmazingSpiderMan'', Superman brings their old friendship up when he confronts Lex.
--->'''Superman:''' We were friends once, Luthor... long ago. For a time, I hoped we could be friends again – Maybe we will be, someday – but in the meantime, we are enemies, because you chose lawlessness, and I chose law!
** In ''Comicbook/WarWorld'', Comicbook/MartianManhunter warned Superman that if he took another step closer to a crypt J'onn was tasked with guarding it might mean the end of their friendship. Superman didn’t listen and J'onn attacked him. Later Clark endeavored to retrieve an artifact stolen from that crypt in hopes of being forgiven by J'onn. [[spoiler:His fellow Leaguer eventually did so]].
--->'''Martian Manhunter:''' I gave you fair warning, Superman — a good deal more warning than I would have given anyone else! I did so because you were my friend — but the bonds of friendship can only be stretched so far before they break!
* ''Comicbook/{{Supergirl}}'':
** In the post-Crisis storyline ''Comicbook/NewKrypton'' Supergirl broke up with her childhood friend Thara Ak-Var when she believed she aided and abetted her murderer's father. Later on, they reconciled after a fashion, but their friendship was still strained.
** In the ''Comicbook/{{New 52}}'' universe, Supergirl befriended Siobhan "Silver Banshee" Smythe shortly after arriving in Earth. However she broke it off when she thought Siobhan was using her. When they meet again during the events of ''Comicbook/RedDaughterOfKrypton'', they fought. Siobhan blamed herself for their friendship's end, but after a while Kara blamed herself for ruining it.
** ''ComicBook/ElseworldsFinestSupergirlAndBatgirl'' gives two instances:
*** Comicbook/{{Supergirl}} regarded Luthor as a kind of father figure... until she learned that [[spoiler:he murdered her baby [[Franchise/{{Superman}} cousin]]]].
*** Likewise, Luthor and Hamilton's friendship broke off because Hamilton felt guilty for helping Luthor [[spoiler:murder a baby and wanted to expose him]].
** Zigzagged in ''ComicBook/SupergirlCosmicAdventuresInThe8thGrade''. Linda and Lena are friends. When Lena finds out that Linda is Supergirl, she breaks their friendship off and tries to kill Linda. Then she loses her memories and they are friends again. Then she gets them back and goes back to want to kill Linda. At the end, she lets her hatred go. On Linda's side, though, she never stops from considering Lena her friend.
--->'''Supergirl:''' Lena... I'm still me! I'm your best friend!\\
'''Lena:''' Not anymore... Not now that I know the truth! You're my enemy now. I have no choice but to destroy you!
* From ''Franchise/{{Batman}}'':
** Bruce and Harvey Dent[=/=]ComicBook/TwoFace embody the trope perfectly, although Harvey was mainly a friend of Batman and not Bruce. Dent was one of the first people of authority to support Batman, but after an incident which caused his transformation into Two-Face, the two become enemies. Notably, Batman is lighter in his dealings with Dent compared to his other villains.
** Bats and Thomas Elliot/Hush have this going as well. The two were childhood friends, but Tommy's mother would constantly tell him to be more like Bruce, which annoyed him. Eventually, Tommy tried to murder his own parents (his father was abusive) and gain their fortune, but Bruce's dad saved Tommy's mom, which he never quite got over. When Bruce's parents later died, Bruce went around travelling the world and living the life Tommy wanted to live, while Tommy was stuck at home caring for his now frail mother. After his mother tries to cut Tommy off from the fortune, Tommy kills her. He leaves for med school and to travel the world soon after, and when the Riddler eventually tells Tommy that Batman is Bruce Wayne, he tries to ruin his life on a consistent basis.
* In ''ComicBook/AllFallDown'', the Pantheon tries to reason with [[spoiler:Pronto]] this way. They don't quite succeed.
* [[ComicBook/CaptainAmerica Steve Rogers]] and [[ComicBook/IronMan Tony Stark]] in ''Comicbook/CivilWar'', which was basically portrayed as a particularly volatile break-up/divorce. With Steve [[DeathIsCheap coming back from the dead]], their relationship has since improved, not a little because fighting each other tore them both up pretty badly in the first place.
** And again during ''ComicBook/JonathanHickmansAvengers'', when Steve realises Tony reformed the Illuminati, and then wiped his memory about it. The last portion of the run involves Steve relentlessly pursuing Tony over everything else, including the imminent end of all existence.
* John Walker, a former Captain America and current [=USAgent=], was once a member of the Bold Urban Commandos alongside Battle Star, Left-Winger and Right-Winger. When the US Government decided to only take John and Battle Star, Left and Right were so furious at this that they opted to reveal John's identity, leading to John's parents getting murdered at the hands of the PoliticallyIncorrectVillain group the Watchdogs. The end result leads to John pummeling the two to a pulp and leaving them to die in a burning oil refinery.
* ''ComicBook/{{Watchmen}}'' Rorschach and Nite Owl II/Dan who were crime fighting buddies before the novel, now share a tense relationship. Rorschach even somewhat disdains Dan's lifestyle, but as the story progresses they partly rebond and face the BigBad together.
* The eponymous character of ''ComicBook/TheMightyThor'' and his adopted brother, Loki, of the CainAndAbel variety.
* Subverted in ''ComicBook/GreenLantern ComicBook/WrathOfTheFirstLantern'' with Sinestro and Hal Jordan. Hal asks Sinestro if they were ever truly friends. Sinestro responds with, "That's the tragedy of all this. We'll always be friends."
* ''ComicBook/AfterlifeWithArchie'' presents Veronica's and Betty's relationship as this. Veronica and Betty were friends in middle school until Archie came to town. After that Veronica's AlphaBitch personality became directed at Betty. They usually hate each other.
* ''ComicBook/InjusticeGodsAmongUs'' shows that Batman and Superman used to be very close, enough so that Superman asked Batman to [[spoiler: be his unborn son's godfather.]] Unfortunately, when [[spoiler: the Joker finally broke him,]] Superman's increasingly-rapid fall down the slippery slope eventually culminated in [[spoiler: Superman breaking Batman's back, ending the World's Finest once and for all.]]
* Franchise/TheFlash III (Wally West) and Reverse-Flash II/Zoom (Hunter Zolomon) used to be friends. Hunter was a police profiler who met Wally when he'd already been the Flash for a few years, and Hunter had a bad knee. Hunter's knee was shot by a B-list Joker knock-off early in his career due to a bad call he made, which caused the death of his father-in-law, Hunter's divorce from his wife Ashley, and his firing from the FBI. Hunter liked Wally because he had a public identity and was an open-book, while Wally liked Hunter because Hunter reminded him of his dead mentor Barry Allen (The Flash II). Eventually, Hunter's spine was be damaged by Gorilla Grodd, which Wally blamed himself for. Hunter lost his ability to walk, and asked Wally to use the Cosmic Treadmill to go back in time and stop him from making his bad call. Wally refused, citing examples like Professor Zoom (Reverse-Flash I) as to why time travel is dangerous and unpredictable. Hunter says Wally refused because he has never experienced personal tragedy, and later tries to use the treadmill himself which ended up giving him time-based powers which effectively gave him superspeed (though he can't time-travel). With his new powers, Hunter decides that in order to make Wally a better hero, he must give Wally not only a great villain to face (which is why he took up the Reverse-Flash moniker), but also as much tragedy as possible. Hunter never outright tries to kill Wally, since this would defeat the purpose of why he does what he does, and Wally still feels responsible for Hunter's fall from grace.
* ComicBook/DruidCity: Jack and Hunter. In the backstory, Hunter and Jack were colleagues, roommates, and fast friends. After Hunter betrayed Jack's trust to get the jump on submitting a groundbreaking article, all of that changed. In the present storyline, Jack is presented as a rather justified antagonist. The two characters are still willing to talk things out over the course of the series, but the point of each interaction is ultimately one-upmanship.
* In the ''[[ComicBook/MyLittlePonyFiendshipIsMagic Fiendship is Magic]]'' tie-in comics based on ''WestewrnAnimation/MyLittlePonyFriendshipIsMagic'', Sombra punishes his only childhood friend for what he saw as betrayal by making her home town ''vanish'' while she was away.
* Adam Brashear, the Blue Marvel, and Connor Sims, the Anti-Man, were once war buddies who wound up assigned to the same super-science project, which ended up going wrong and giving them superpowers. However, Connor's powers ended up driving him insane, which eventually resulted in the death of Adam's wife Candace. [[ComicBook/Ultimates2015 When they meet again]], the normally good-natured Adam is furious at seeing him, even though Connor can't remember what happened.

[[folder:Fan Works]]
* It's common in ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' fanfiction to show that Celestia and Luna used to be friends with [[MadGod Discord]] before he turned into an EvilOverlord and they had to use the Elements of Harmony on him.
* The entire point of the the sadly discontinued [[Franchise/LyricalNanoha Nanoha]] DarkFic 'Betrayers', which divides the cast into a bloody civil war. Spoken practically word for word by Fate.
* In the WesternAnimation/JackieChanAdventures fic ''Fanfic/QueenOfAllOni'', after Jade turns evil once again, her family and friends still care deeply about her, to the point that they are willing to FIGHT her so that they can return them to normal, even though her feelings towards them have been twisted by Daolon Wong's faulty spell, especially [[spoiler: towards Tohru, since he became Uncle's apprentice instead of her]].
* In the VisualNovel/KatawaShoujo fanfic ''Fanfic/{{Reconciliation}}'', Hanako has this with Lilly and Hisao. The fic takes place after her bad ending, in which [[spoiler:she snapped over being pitied by Hisao and angrily said she hated him and Lilly]], then isolated herself from them out of guilt. This leads to an awkward moment when Hanako introduces her publicist and friend Sho to Lilly, who is unable to describe Hanako as anything more than someone she knew in high school, despite never having been angry with her for how she acted. [[spoiler:By the end, the two have renewed their friendship and Lilly visits Hanako in Japan to catch up]].
* Obviously crops up in ''FanFic/InnerDemons'', as the entire plot is driven by Twilight Sparkle succumbing to her EnemyWithin and becoming the new BigBad her friends have to fight.
** Also an element in [[{{Deuteragonist}} Apple Bloom's]] subplot. Her friendship with the other Cutie Mark Crusaders (primarily Scootaloo) falls apart after an argument in which she makes it clear she wants to take her search for her Cutie Mark more seriously. [[spoiler: Later on, Scootaloo and Sweetie Belle are [[MoreThanMindControl talked into]] {{Face Heel Turn}}s, while Apple Bloom stays on the side of the protagonists.]] Notably, Sweetie Belle clearly still cares about their friendship and wants it back [[spoiler: which is why she tries to talk Apple Bloom into switching sides as well]].
%%* In ''Naruto Veangance Revelaitons'', this trope could be said to define Ronan and Taliana's relationship, along with FaceHeelRevolvingDoor on Taliana's part. After several chapters of Taliana repeatedly switching sides, Ronan arbitrarily loses patience with her and gets a divorce from her. She makes several more attempts to kill Ronan for Madara, but he's still attracted to her [[spoiler:despite her being his mother]], and they have sex on a few occasions. [[spoiler:Then the author broke up with the girlfriend who served as Taliana's inspiration, and Ronan kills her while claiming that [[RetCon he knew all along that she was evil]].]]
* In ''Fanfic/WeekendAtHisaos'', Hisao ends up encountering his friends who, in the prologue to the game, stopped visiting after a few weeks, and hears that they have a get-together planned with his former crush Iwanako. It takes some coaxing from Shizune and Misha before Hisao decides to attend, but the meeting goes fairly well [[spoiler:and his old friends end up getting invited to his wedding a few years later]].
* From chapter 20 of ''Fanfic/AceCombatTheEquestrianWar'':
--> '''Rainbow Dash''': Gilda! Tell me, why are you doing this? We used to be friends!
--> '''Gilda''': That’s right, Dash! We ''used'' to be! But you chose those ponies instead of [[FoeYay me]]!
* In the ''FanFic/PoniesOfOlympus'' series, Rarity and her [[TheRival rival]] Ran Biao used to be friends when they were growing up together in [[OldMaster Lao Wu]]'s dojo, until Ran Biao grew [[GreenEyedMonster jealous]] over Rarity's [[AlwaysSecondBest superior talent]], and crossed the line by seducing and stealing Rarity's LoveInterest Razorwing. Rarity never forgave her for that, and they've hated each other ever since.
** As it turns out, [[spoiler: Ran Biao didn't steal Razorwing — she was [[AllLoveIsUnrequited in love with Rarity]], and when she [[ClingyJealousGirl tried to get Razorwing to break up with her]], he [[RapeAsDrama raped her]]. Rarity misunderstood the situation and [[NiceJobBreakingItHero left them to it]]; Ran never forgave her for that.]]
* In the ''Webcomic/AxisPowersHetalia'' fanfiction [[http://apostlegirl.livejournal.com/ Ignorance, My Bliss,]] the nations get energy boosts by [[spoiler:drinking each other's blood, essentially making them all addicts.]] They discover that [[spoiler:no one has fed off of America ever, meaning that his blood will give them a lot of strength,]] and don't hesitate at all to chase him down and [[spoiler:drain him of his blood. Japan even tells America that though they're friends, his blood is just too tempting.]] And then, it turns out that [[spoiler:even ''Canada'' turned on America, only pretending to save him so he'd have a chance to get him alone.]]
* Known to happen in {{Deconstruction Fic}}s of the episode [[Recap/MyLittlePonyFriendshipIsMagicS2E8TheMysteriousMareDoWell "The Mysterious Mare Do Well"]], including ''Fanfic/TheWorldJumper''.
* The relationship between Roll and Maylu in ''[[FanFic/MaylusRevenge Maylu's Revenge]]''.
* In ''Fanfic/NecessaryToWin'', Ami and Takako follow this trope. They were friends since they joined the Nishizumi School together, until Ami's disagreement with Takako over the latter's harsh methods of discipline as coach of Black Forest drove a wedge between them. Both remain close with their mutual friend, Kikuyo, though.
* This is a common trope in ''Literature/{{Worm}}'' fanfics, such as ''Fanfic/{{Atonement}}'', ''FanFic/{{Intrepid}}'', ''Fanfic/QueenOfTheSwarm'', ''FanFic/ATaleOfTransmigration'', and ''FanFic/{{Outcry}}''. Emma and Taylor have a shared friendship that ended after Emma ends up being attacked and, seeking to change her world view, leads to Taylor [[TraumaticSuperpowerAwakening triggering]] from a bullying campaign gone too far. Even if Emma tries to redeem herself, like in those fanfics listed above, Taylor will not forgive her in several of those stories.
* ''Fanfic/AdviceAndTrust'': Misato and Ritsuko were friends, but due to Ritsuko's behavior they're falling apart. In chapter 8, Misato wonders if Ritsuko is still her friend.
* In ''Fanfic/GhostsOfEvangelion'' Misato tries to remember Ritsuko for what she was rather than she became when they broke their friendship off.
-->'''Misato:''' I compared you to my best friend, not to the monster she became.
* In ''Fanfic/ThousandShinji'', Misato and Ritsuko were friends... until the former got wind of the secrets of NERV. Misato's last straw was Ritsuko mocking her family's destruction [[spoiler:shortly after murdering Kaji.]] Misato [[spoiler:attacked her, and when Ritsuko tried to kill her in retaliation, Misato stabbed her.]]
-->“I... I... thoughts not mine... Ritsuko my... friend? I... I didn’t want to believe... fed up with her... fed up... had to hit that bitch. Had to hit that bitch! Feel her flesh crumple beneath my fist... yeah, just hit her, just make her shut up. Shut up! Shut up!”
* Asuka and Rei in ''Fanfic/ChildrenOfAnElderGod'' managed to get along, even though both girls liked the same boy… but after the battle against the [[EldritchAbomination Violator]] where [[spoiler:Rei hurt Asuka unwillingly but brutally,]] their friendship all but came to an end.
* In ''Fanfic/NeonGenesisEvangelionGenocide'':
** Misato and Ritsuko subverted this at the beginning. They broke their friendship off during the Angel War, but they kind of made up afterwards (though emphasis on ''kind of''). Misato also considered that Ritsuko was her only friend left.
--->Her work was all that mattered to her. But that didn't invalidate the fact that Ritsuko was the one person Misato could call a friend. Even if she disagreed with her, she could at least be honest. Otherwise, she wouldn't have come.
** However, when she finds out that [[spoiler:that Ritsuko has used Asuka to test the Emerald Tablet, [[AIIsACrapshoot a dangerous sentient computer program]], by putting it inside Unit-02, leading to Asuka being driven to the brink of insanity, [[NewMeat the new pilot, Keiko]], getting seriously injured, and Shinji almost getting killed]], Misato decides that [[ThisIsUnforgivable she can't forgive Ritsuko this time]]:
--->"I swear she's done some awful things in her life, but I will never forgive her for that."
* Subverted in ''Fanfic/TheSecondTry'' with Misato and Ritsuko. They almost broke their friendship off, but an unintended side-effect of Shinji and Asuka’s meddling with the timeline was they patched things up after [[spoiler:the destruction of the clones of Rei.]]
* ''Fanfic/OnceMoreWithFeeling'': After finding out the truth about the real goals of NERV and SEELE, Kaji has no choice but treating his old friend Ritsuko like an enemy.
-->After all, if Shinji was right, Ritsuko, good ole Rits herself was fully aware of the ultimate goals of the Evangelion project.\\
Hell, she was up to her ever so pretty neck in it.\\
Meaning he had no choice but to treat her as an enemy. Someone he had known for close to a decade and he thought he knew well... and thought of as a friend.\\
It was no easy shift to make in ones thinking, even for him.
* In ''Harry Potter and the Grand Trainer Tournament'' we learn that Jack Kenway and Lance Blackthorn were once best friends very much like James and Sirius were. When Koga of the Elite 4 caused the death of Jack's aunt and uncle Lance wanted to handle it through proper channels... and Jack saw this as Lance looking to cover the deaths up. The two ended up the commanders on the opposite side of the Johto/Kanto War and it has take a decade for the two to slowly begin trying to patch things up.

[[folder:Films -- Animated]]
* ''Disney/TheFoxAndTheHound'' starts off with the two titular characters frolicking and playing as children, but when they become adults and Copper is now a hunting dog, an accident involving the two leads where Copper's mentor, Chief, is nearly killed, Copper ends their friendship and swears revenge. [[spoiler: At the climax, Tod rescues Copper from [[BearsAreBadNews a giant grizzly bear]]. Copper, amazed Tod saved his life despite everything that happened, returns the favor by stepping between his master's gun and the weak exhausted fox, and Amos eventually relents.]] In the end, the two reconcile, but are forced to part ways forever.
* In ''WesternAnimation/ThePrinceOfEgypt'', Rameses and Moses were raised as brothers. They became enemies when Rameses was Pharaoh and Moses returned from hiding to free the Hebrews from bondage.
-->"You who I called brother, how could you have come to hate me so?"
* In ''WesternAnimation/{{Coco}}'', Hector Rivera and Ernesto de la Cruz [[spoiler: were once best friends and musical partners. When Hector got home sick and wanted to return home to his daughter, Ernesto murdered him for his songs and guitar. Ernesto became famous as a result.]]
* This is what happens to Anna and Elsa in ''Disney/{{Frozen}}.'' Elsa shuts Anna out of her life and refuses to play with her. Anna is convinced that Elsa doesn't love her anymore. However, Elsa did this because she wanted to protect Anna from [[IAmAMonster herself]]. This is because Elsa accidentally almost killed Anna with her powers when they were playing, and Anna doesn’t know this because Grand Pabbie altered her memories so that she doesn’t remember Elsa’s powers so he could heal her. During an argument between the two at Elsa's coronation, Elsa loses control of her powers again, forcing her to flee and causing Anna to realize what Elsa had kept hidden all these years. However, Anna [[TheDeterminator refuses to give up on Elsa]] and continues to [[ThePowerOfLove love her]], believing that they can once again become friends. [[spoiler:Anna even goes as far as making a HeroicSacrifice for Elsa, and saving herself from her DisneyDeath since this was an ActOfTrueLove. After Elsa realizes that love fixes everything, [[HeterosexualLifePartners they reconcile and eventually becomes best friends with Anna]].]]
* In ''WesternAnimation/MyLittlePonyEquestriaGirls2013'', the Humane Five were friends at one point in the past, but they had drifted apart when [[AlphaBitch Sunset Shimmer]] sabotaged their friendship. However, Twilight manages to clear up the misunderstanding and get them all back on friendly terms.
* Kai, the BigBad of ''WesternAnimation/KungFuPanda3'', was originally brothers-in-arms with series BigGood Master Oogway. Things fell apart when Kai brought his wounded friend to a village of pandas to heal him with the power of chi. Being too power-hungry for his own good, Kai began stealing chi from others for personal gain, forcing Oogway to seal him away in the Spirit Realm for 500 years. The belief that he was betrayed and [[NeverMyFault refusal to admit he did anything wrong]] has left Kai quite a bitter fellow indeed.

[[folder:Films -- Live-Action]]
* ''Franchise/StarWars'': Taken to the extreme in ''Film/RevengeOfTheSith'', the third film of the prequel trilogy with Anakin Skywalker and Obi-Wan Kenobi. Over the course of the film, the two go from best friends (and to Anakin, a ParentalSubstitute) to attempting to kill each other.
* ''Film/GoldenEye'': Film/JamesBond and [[spoiler:Alec Trevelyan/006]] once had this dynamic, but once [[spoiler:[[BigBadFriend Alec]]]] betrayed England and MI6, the two became bitter ArchEnemies.
* ''Film/ThirteenGoingOnThirty'' deals with this. Jenna abandons Matt when she becomes more popular. They reconcile, though. Has something to do with TimeTravel.
* In ''Film/FireOverEngland'', Sir Richard Ingolby, the English {{Privateer}}, unknowingly attacks the galleon of his former friend, Don Miguel de Casanz -- when they encounter each other in battle, Ingloby tells his son, Michael, "We were friends once." "Enemies now!," shrieks Michael, and attacks.
* ''Film/SpyKids'' had Gregorio and his estranged brother, Film/{{Machete}}. [[NoodleIncident Neither one can remember why they are estranged]], so they team up.
* ''Film/AmericanHistoryX'' features this as a result of a HeelFaceTurn, combined with RapePortrayedAsRedemption.
* ''Film/XMenFilmSeries''
** Bobby Drake and Pyro were friends in ''Film/X2XMenUnited'', but are adversaries in ''Film/XMenTheLastStand''.
** ''Film/XMenOriginsWolverine'' details the relationship between James Howlett (Wolverine) and Victor Creed (Sabretooth), who are half-brothers. They were BashBrothers to the very end until Victor's sociopathy went off the deep end and caused James to lose his connection with Victor.
** The whole premise of ''Film/XMenFirstClass'' is to show how Charles Xavier and Erik Lehnsherr became friends and then ended up on opposite sides with different ideals. There's also a subplot about Raven Darkholme's fallout from her relationships with Charles and Hank [=McCoy=]. It's a theme in the original trilogy as well, where Professor X and Magneto are FriendlyEnemies, and the beginning of ''Film/XMenTheLastStand'' depicts younger--and closer--versions of them, when they were still working together.
* Mark Zuckberg and Eduardo Saverin in ''Film/TheSocialNetwork'' were once good friends but after [[spoiler: Mark had Eduardo kicked out of the company]], all bets were off.
* ''Film/MissionImpossibleIII'' has this between Ethan Hunt and [[spoiler:John Musgrave]].
* Franchise/MarvelCinematicUniverse:
** In ''Film/IronMan2'' Tony is alone after he disappointed all of his friends. [[spoiler:He makes up for it in the end.]]
** Sif and the Warriors Three start to feel this way about Loki in ''Film/{{Thor}}'' when he refuses their appeal to de-banish the titular character, in their mind betraying him. Exactly how much he feels this way about them and how much is show is up for debate at this point.
** In ''Film/CaptainAmericaTheWinterSoldier'', [[spoiler: Nick Fury and Alexander Pierce were allies in the past. Now, Pierce is with HYDRA and attempted to assassinate Fury. It fails, and he retributes the favor at the end.]]
--->'''Nick Fury:''' You know, there was a time I would take a bullet for you.
** In ''Film/CaptainAmericaCivilWar'', ComicBook/IronMan basically says a variation of this to Cap as they are about to face off.
---> '''ComicBook/CaptainAmerica:''' I'm sorry, Tony. You know I wouldn't do this if I had any other choice. But [[ComicBook/BuckyBarnes he's]] my friend.\\
'''Iron Man:''' [[TearJerker So was I.]]
* In ''Film/WalkingTall2004'', the villain and the hero were childhood friends before taking very different paths in life as adults. The villain reflects on this with a hint of sadness before the final fight.
* In ''Film/RaidersOfTheLostArk'', Franchise/IndianaJones's friendship with his mentor Abner Ravenwood fell apart after he was romantically involved with his daughter Marion.
-->'''Marion Ravenwood:''' You know he loved you like a son. Took a hell of a lot for you to alienate him.\\
'''Indiana Jones:''' Not much, just ''you''.
* In ''Film/TheHuntForRedOctober'' Tupolev describes his relation ship wiht Ramius like this after the latter's defection. In a bit of a twist, Ramius doesn't seem to consider himself particularly close to Tupolev, and is outright disdainful of Tupolev's abilities as a sub captain.
* In ''Film/TransformersTheLastKnight'' this is done by ''Megatron'' (of all people) to Optimus.
-->'''Megatron:''' We were brothers once.
-->'''Optimus:''' ''[[PreasskickingOneLiner Once]]''.
* In ''Film/Ebenezer1998'' Marlowe says the only reason he came to help Scrooge is because at one time they were friends, which he finds hard to believe now.

* Discussed but downplayed in the ''Literature/{{Alterien}}'' series. Abigail asks Oberon if Ulysses River, a superhuman assassin who just tried to kill his sister, and he were friends. Oberon replies very matter-of-factly they were not friends, only teammates.
* Played straight in the ''Literature/AstralDawn'' series. Caspian Knoll and Ciaran Devlyn were once the best of friends in another life. After their deaths, Caspian went on to be reborn in other lives while Devlyn went straight to Hell. That put a pretty big gap between the fellows who would eventually become deeply at odds over the fate of Celestial City.
* In ''Literature/MemoirsOfAGeisha'', the friendship between Sayuri and Pumpkin became strained once two rivals, Hatsumomo and Mameha, adopted each of them. And once Sayuri became more popular than Pumpkin, even having Mother formally adopted her, Pumpkin grew envious.
* [[spoiler:Peter Pettigew]] in ''Literature/HarryPotter''. The other surviving Marauders view him with extreme disgust for siding with Voldemort.
** As revealed in ''[[Literature/HarryPotterAndTheDeathlyHallows Deathly Hallows]]'', [[spoiler:Severus Snape]] for [[spoiler:Lily Evans, later Lily Potter]]. He ''really'' shouldn't have hung out with [[spoiler:the wannabe [[{{Mook}} Death Eaters]] and [[FantasticRacism pureblood supremacists]] in Slytherin...]]
** The backstory of Hogwarts reveals that founders Godric Gryffindor and Salazar Slytherin were best friends before they had a falling out over the latter's FantasticRacism toward Muggle-born Wizards. This would lead Slytherin to leave Hogwarts forever.
* In ''Literature/WarriorCats'', Fireheart and Onewhisker were friends ever since they were both young warriors. When [[spoiler:Onewhisker becomes leader of [=WindClan=]]], he is harrassed for being such a close friend to a cat of another Clan that he breaks off the friendship and views them more as enemies than anything.
* ''Literature/TrappedOnDraconica'': [[TheGoodKing Alister]] with [[EvilOverlord Gothon]]. They fought in a crusade together.
* The classic Dutch novel ''Literature/{{Oeroeg}}'' exploits this trope for drama in the relationship of the two main characters, a white Dutch boy of a rich family and a native Indonesian boy of a servant family. They grew up together, separated during high school and when the main character finally returns to Indonesia (during the 1940s uprisings) he is told by his former friend to leave since he has no more business in the country.
* In ''Literature/TheSagaOfDarrenShan'' Darren and his best friend Steve were an inseparable duo but little did they know destiny had other plans for them.
* The ''Literature/AgeOfFire'' series has [=RuGaard=] and [=NiVom=]. They were close comrades during their years in the Drakwatch together, but the relationship soured after the [[DecadentCourt political intrigues of the Lavadome]] saw [=NiVom=] exiled and [=RuGaard=] made Tyr (a position that ''should'' have been [=NiVom's=]).
* In the Creator/OHenry short story ''After Twenty Years'', the main character is waiting for Jimmy Welles, his best friend from his youth, since they had promised to meet again at a certain spot after he struck out on his own twenty years ago. He explains all of this to a lone police officer who is patrolling the area. [[spoiler:The main character is a notorious wanted criminal and Jimmy ''is'' the policeman. Officer Welles can't bring himself to arrest his old friend personally and calls in another officer to make the collar.]]
* In ''Literature/{{Updraft}}'', Kirit and [[spoiler:Nat, her friend from her home tower,]] eventually come to odds due to one of them challenging the Singers and one of them now ''being'' a Singer. Their TrialByCombat ends with [[spoiler:Nat apparently dying, but actually surviving. They later reconcile]]. Another example might be Kirit and [[spoiler:Sellis, a fellow Singer trainee]], but that friendship is more illusionary based on not ever really understanding where Kirit was coming from.
* Michael and Tony of ''Literature/{{Relativity}}'' were best friends growing up, but an as-yet-undisclosed incident in college drove them apart.
* Anne and Neely in ''Literature/ValleyOfTheDolls'' are close friends throughout the book, until [[spoiler: Neely and Lyon have an affair. Anne forgives Lyon, but her friendship with Neely is shattered.]]
* Jess and Bridget at the start of the ''Literature/JessicaDarling'' series. They grow closer again towards the end of the first book, but they never quite become the best friends they were growing up. Likewise, Jess and Dori in the prequel series, which also shows how Jess and Bridget drifted apart in the first place. Since a running theme of the books is that people and relationships change over time, this trope is almost a given.
* In ''LightNovel/TheUnexploredSummonBloodSign'', [[ThouShaltNotKill Kyousuke]] and [[spoiler:Mary Ann]] were lovers three years ago until she killed someone. Since she had promised him she wouldn't, he couldn't trust her after that, and things escalated from there into a massive conflict that defines their lives right up to the present day.
-->''“Eh heh heh. We’ll be together forever, brother!”\\
“Hm? Why even bother mentioning something so obvious???”''


[[folder: Live-Action TV]]
* ''Series/TwentyFour'':
** This serves as one of the plots between Jack Bauer and Tony Almeida in the seventh season. Although the two originally started off on bad terms, Tony eventually became one of the very few people Jack personally trusted with his life. [[spoiler: By season seven, a broken Tony has discovered the true identity to the conspiracy that led to the death of his family and his ties to the government, leading him to resort to terrorism in order to get the guy. Jack rightfully sees Tony as a traitor to his country betraying the memory of his loved ones, and Tony in turn sees Jack as nothing but a sellout and a hypocrite by continuing to work with the same government they've both lost faith in.]]
** During the early seasons, Senator-turned-President David Palmer had his Chief of Staff, Mike Novick, whom he put all his trust into. However, that ends when Mike betrays Palmer to help the rest of the U.S. government invoke the 25th amendment and displace Palmer, feeling his inaction against a potential (and false) threat could lead to disaster. Mike [[MyGodWhatHaveIDone quickly ends up regretting his actions]] and [[TheAtoner and helps out against the real mastermind]], but it's too little, too late: Palmer angry and hurt at his betrayal, bitterly fires Novick after everything is wrapped up. On a bittersweet note, the two do manage to make amends late into the fourth season [[spoiler:before Palmer is killed at the beginning of Season Five.]]
* ''Series/AgentsOfSHIELD'':
** TheReveal that [[spoiler:Ward]] had been EvilAllAlong came around two-thirds of the way through Season 1. Instead of killing him off in the finale as was originally planned, the writers were impressed enough with [[spoiler:Brett Dalton's]] performance that they decided to keep the character in the main cast. They do this by [[spoiler:having the rest of Team Coulson keep him prisoner on their new base, using him as an informant against HYDRA.]]
** Due to the [[spoiler:HYDRA uprising]] in Season 1, this becomes the case for a lot of regular characters within S.H.I.E.L.D., most notably [[spoiler:[[BigBad John Garrett]]]] and [[spoiler:Jasper Sitwell]]. Unlike [[spoiler:Ward]], however, they're all dispensed with by the finale.
* ''Series/{{Angel}}'':
** Wesley Wyndam-Pryce. After Wesley translated a prophecy that predicted for Angel to kill his son, Wesley took the child to save his friend from his horrible fate. When he was about to leave town with the boy, he got his throat slit by TheDragon of Angel's nemesis and the baby was now taken from him and brought to a Hell dimension. His friends didn't take it that well. As a result to this, his friends never wanting to see him again, as well as the revelation that the prophecy he was trying to prevent was in fact fake and that he [[SenselessSacrifice sacrificed everything for nothing]], he takes a major in [[TookALevelInBadass Badassery]] and is from then on very reserved concerning his former friends.
---> '''Gunn:''' What happened to you, man?\\
'''Wesley:''' I had my throat cut and all my friends abandoned me.\\
'''Wesley:''' I have no idea where Angel is, Lilah, or what happened to him. And I really couldn't care.\\
'''Lilah:''' Wow. That was cold. I think we're finally making progress. Come on. Doesn't it bother you just a little bit? The not knowing?\\
'''Wesley:''' That part of my life is dead. Doesn't concern me now.
*** Subverted: He was looking for Angel the whole time.
*** Double Subverted: After he finds him, he still stays the hell away.
** Wesley steadily reconciles with them during the fourth and fifth seasons, however - despite the pain of what happened, Angel later states that overcoming this trope made their friendship afterward stronger than ever.
** Also happens in the second season, when Angel fires Wesley, Gunn and Cordelia from Angel Investigations.
* ''Series/{{Arrow}}'': Oliver and Slade. They became close friends and allies when trapped on the island, but between exposure to [[PsychoSerum Mirakuru]] and [[spoiler: Shado's death]], Slade came to hate Oliver.
* ''Series/BabylonFive'':
** General Hague is killed in battle after organizing a mutiny against [[PresidentEvil President Clark's]] authoritarian regime. It's mentioned that the attacking ship was captained by a close friend of Hague's who had known him at the academy but nonetheless had remained loyal to Clark. The other officer is presumably killed when Hague's ship destroys it soon after. Major Ryan warns that this will be the case for most of their enemies in battle now.
** In the fourth season Michael Garibaldi and [[TheCaptain Sheridan]] have a falling out, evidently caused by Garibaldi's collapse after being captured by the Shadows. It is later revealed that he has been {{brainwashed}} by [[spoiler: [[TheChessmaster Alfred Bester]]]], who uses the [[ThePawn unwitting]] [[spoiler: Garibaldi]] as a lever to alienate [[spoiler: [[WoobieDestroyerOfWorlds Lyta]]]] so they'll be forced to make a deal with [[spoiler:Bester]], [[HeelFaceTurn trick]] [[spoiler: Sheridan]] into [[KnockoutAmbush walking into a trap]] so he can be arrested by [[spoiler: [[PresidentEvil President Clark]]'s]] men, and [[TheMole discover]] the plot by [[spoiler: [[WellIntentionedExtremist William Edgars]]]] to infect [[spoiler: [[FantasticRacism Telepaths]]]] with an engineered plague. Of course, once [[spoiler: Garibaldi]] has been released from the conditioning, [[ReformedButRejected none of his friends will have anything to do with him]], and the only way for him to regain their trust is to [[BigDamnHeroes bust]] [[spoiler: Sheridan]] [[GreatEscape out of prison]]. It's easy to see why [[spoiler: Bester]] is considered to be the MagnificentBastard of the show.
* ''Series/BattlestarGalactica2003'':
** Apollo and Starbuck are a looping On-Off-Couple/Friends. When the fleet reaches New Caprica however [[spoiler: and Apollo and Starbuck sleep together]] they seem to share a now very distant relationship. We only learn later on why.
** Happens to the Old Man and Col. Tigh. Twice actually. The first time when [[spoiler: the exodus from New Caprica succeeds and Saul can't really deal with what happened]], the second time when [[spoiler: the XO reveals to Admiral Adama that he has been a Cylon all the time]]. They manage to reconcile eventually.
* ''Series/BlackAdder'' fans have a popular HeadCanon theory that Captain Blackadder and Captain Darling were good friends before the war started, but they fell out after Darling got out of being in the trenches to be General Melchett's PA.
* ''Series/{{Bones}}'':
** Zach turned out to be [[spoiler: working for a SerialKiller]]. This [[Film/ThePrincessBride puts a damper on his relationship]] with the other characters. He is promptly written out.
** This really becomes a SubvertedTrope because scenes showing him in a mental institution afterwards show that after the initial shock, his friends are actually very supportive, visiting him and trying to help him recover. They know that he's still their friend, he was just [[spoiler:indoctrinated by what passes for an Evil Mastermind into doing his bidding]] because, despite his high intelligence, he is [[TheIngenue ridiculously naive]] and was [[CorruptTheCutie taken advantage of]]. Everyone is more... [[WhatTheHellHero baffled]] than feeling betrayed.
* ''Series/BuffyTheVampireSlayer'':
** Buffy left her friends after she had to kill Angelus/Angel seconds after his soul was restored. She took off to Los Angeles, leaving her friends behind. Her return to Sunnydale is awkward - at best.
** The entire point of Faith becoming TheDragon to the Mayor.
** Cordelia also fits since 'Lovers Walk'. Though she doesn't fully repair her vitriolic friendship with the Scoobies completely, however, they manage a reconciliation by the end of the third season, and all interactions between them from then on are on generally good terms.
** Rupert Giles and Ethan Rayne. In their youth, they were part of a group of mystics who summoned demons for kicks. Giles has since moved on, while Ethan remains a worshipper of chaos and professional villain.
** Willow when she turned evil for a part of the series.
* ''Series/DoctorWho'': The Doctor and [[ArchEnemy the Master]] were at school together back on Gallifrey, and are still on FriendlyEnemy terms most of the time. The Third Doctor called the Master his best enemy and openly looked forward to their meetings. The Tenth Doctor's finale featured reminiscences of their shared childhood. Apparently the Master was a rich boy: his father had estates where they would play together. The Doctor also gifted his daughter with a brooch when she got married.
** According to [[Franchise/DoctorWhoExpandedUniverse Expanded Universe]] sources, back in his student days the Doctor was part of a clique made up of fellow nonconformists, which included the future Master, [[EvilutionaryBiologist Rani]], [[Recap/DoctorWhoS6E7TheWarGames War Chief]] and [[Recap/DoctorWhoS2E9TheTimeMeddler Monk]].
* ''Series/{{Friends}}'': Briefly lampshaded in the fifth season, when Ross tries to work things out with Emily by agreeing to never see Rachel again. Rachel convinces Phoebe to set up a new 'group' with her. It didn't happen.
* ''Series/GameOfThrones'':
** Robb executing Lord Rickard greatly fractures House Karstark's ties with House Stark. Catelyn freeing the murderer of Lord Rickard's children probably did not help.
** Jon allowing the Wildlings to go South of the Wall pisses off House Umber's new Lord so much that he allied with the Boltons despite hating them.
** The History and Lore videos indicate that Tywin and King Aerys were tight as nails until the latter's madness and jealousy kicks in.
** Oberyn told Cersei that he last saw Myrcella playing with his daughters at the Water Gardens. It isn't clear if he means his younger daughters or the Sand Snakes of Season 5, but either case they aren't friends after Oberyn's death. This is a major change from the books where absolutely none of his daughters and no one in Dorne, aside from a nutcase knight, wanted to hurt Myrcella.
* ''Series/GossipGirl'': Serena and Blair at the very beginning of the series.
** Pretty much happens all the time due to the fact of bonding and scheming. But especially Dan falls in this category when publishing his books / exposès.
* ''Series/HowIMetYourMother'': Ted and Barney for some time at the end of the third season.
* ''Series/LizzieMcGuire'': [[CoolLoser Lizzie]] and [[AlphaBitch Kate Sanders]], until [[SheIsAllGrownUp Kate's figure filled out]] and she became a popular cheerleader. [[spoiler:They seemed to settle their differences permanently in TheMovie.]]
* ''Series/{{Lost}}'': Michael is another good example. During Season 1, he seems to be a nice and well-liked member of the Losties. When his son Walt is kidnapped in the Season 1 finale, he knocks out Locke and Jack in order to get a head-start going after the Others. When he returns eventually, he decides to betray his friends and lure them into a trap to retrieve Walt.
* ''Series/{{Merlin}}'': Morgana discovers that Arthur is her half-brother in the third series and spends the remainder of that series and all of the next trying to kill him so that she can consolidate her claim on the throne. When they finally come face-to-face at the end of series four, Arthur sadly asks her: "What happened to you, Morgana? I thought we were friends." When Merlin asked her a similar question in series 3, she replied that she hasn't forgiven him for poisoning her. This trope is the only reason Merlin hasn't killed Morgana.
* The MythArc for season 1 of ''Series/MadamSecretary'' is made of this trope. President Conrad Dalton was the Director of the Central Intelligence Agency under UsefulNotes/GeorgeWBush, and present-day CIA director Andrew Munsey, as well as Liz [=McCord=], Juliet, Isabelle, and George, were senior operatives and close friends. By season's end, [[spoiler:Munsey and Juliet have been revealed as ringleaders of a RenegadeSplinterFaction trying to foment regime change in Iran, and Juliet confesses to having [[KilledToUpholdTheMasquerade killed George and Secretary of State Vincent Marsh to keep the secret]].]] Driven home by the closing scene of "[[Recap/MadamSecretaryS1E22ThereButForTheGraceOfGod There But for the Grace of God]]", which shows all six of them enjoying themselves at Liz's retirement party.
* ''Series/MrRobot'': Elliot and Angela turn against each other for most of the third season due to Whiterose's manipulation. Angela starts taking advantage of Elliot's mental illness and uses Mr.Robot to complete Stage 2.
* ''Series/TheOC'':
** Ryan Atwood at the end of Season 1 and the beginning of Season 2 - oh, and the beginning of Season 4. [[spoiler: Leaving the Cohens after Marissa's death, becoming a cage-boxer, driven by revenge and grief along to Placebos 'Running Up That Hill']].
** Seth claims to not care about Ryan and his family anymore, as they try to persuade him to come back to Newport at the beginning of Season 2. They manage to reconcile quickly.
* ''Series/OnceUponATime'': Snow White and the Queen, though due to the age difference it was more a niece and cool aunt relationship. As Snow White grew older and the Queen grew more bitter in her loveless marriage to the King, the two grew to hate each other. Also, the Queen blames Snow White for [[spoiler:being tricked by the Queen's mother Cora into spilling the beans that the future queen was in love with Daniel the stable boy, leading Cora to kill Daniel to force her daughter to marry up]].
* ''Series/{{Revolution}}'': As revealed in [[Recap/RevolutionS1E3NoQuarter episode 3]], captain Jeremy Baker with Miles, during the founding of the Monroe Republic. Not to mention Miles and Monroe, as shown in flashbacks in [[Recap/RevolutionS1E10NobodysFaultButMine episode 10]].
* ''Series/{{Scrubs}}'': Also happens. Especially to Elliot and JD at the beginning of the fourth season. A milder case of the trope though. Their [[WillTheyOrWontThey second attempt at a relationship]] ended badly and for a while they had a "superficial friendship", being generally friendly but not nearly as close as they once were. They became roommates, which brought them a lot closer.
* ''Series/TheShield'': With the end of Season 3 and [[spoiler: the disbandment of the Strike Team]], the relations between its former members are heavily tensed. Especially [[spoiler: Shane, who seems to have crossed the line, thinks very differently about his former best friends:]]
--> '''Army''': "Jesus Christ. [[spoiler: Lem]]'s one crazy-ass white boy. You really used to be tight?"
--> '''Shane''': "Yeah. A lifetime ago."
* ''Series/{{Smallville}}'': [[{{Superman}} Clark Kent]] and ComicBook/LexLuthor, who go from close friends to [[ArchEnemy Arch Enemies]] over the course of the show, while the breakup of their friendship is an obvious ForegoneConclusion throughout the earlier seasons.
* ''Series/{{Supernatural}}'':
** The angel Balthazaar, a former friend of recurring character (and fellow angel) Castiel. At some point during the Apocalypse, Balthazaar went rogue and has started making [[DealWithTheDevil deals]] with humans for their souls. When Castiel discovered this, and Balthazaar tried to get him to do the same, he stated how disgusted it made him, and declared the two of them enemies.
** Gabriel and Lucifer. They used to be very close, as Lucifer claims that he taught his little brother everything he knows. Lucifer then kills Gabriel because Gabriel sided with humans.
** Near the latter end of Season Six, Sam and Dean discover that Castiel [[spoiler: is working with [[MagnificentBastard Crowley]] to gain control of Purgatory and all its souls]]. Castiel tries to [[NecessarilyEvil justify his actions]], but the brothers want nothing more to do with him (especially as of the season finale, where he [[JumpingOffTheSlipperySlope jumped off the slippery slope]]). In an interesting inversion of the previous example, when Balthazaar discovers what Castiel is up to, he is [[EvenEvilHasStandards horrified]] at what his friend is becoming, and starts spying on him for the Winchesters. [[spoiler: [[KilledOffForReal This ends up costing him]].]]
** Castiel is TheAtoner in season 8 and starts repairing his friendship with the Winchesters, although this is complicated by his also being a ManchurianAgent for Naomi.
* ''Series/VeronicaMars'': Used "We Used to Be Friends" by Music/TheDandyWarhols as its RealSongThemeTune, and it shows: [[BackStory as we learn in the first episode]], following the murder of her best friend Lilly, Veronica's boyfriend ignores her (actually, that happened a couple of days prior), her former friends turn against her, and she gets roofied and raped. Thus begins her descent into FilmNoir.
* ''Series/TheWalkingDead'': Rick and Shane - former best buds - share a tensed friendship since the outbreak, partly because [[spoiler: Shane slept with and is in love with Rick's wife]].
* ''Series/MalcolmInTheMiddle'': Malcolm was rejected by all of his "normal" friends when he was placed in the gifted program. Even after he makes new friends, it's still a source of bitterness for him.
* ''Series/DearWhitePeople'': Episode four reveals that Sam and Coco were once friends, since initially rooming together, but had a falling out after racial issues came between them. Later they reconcile somewhat.
* ''Series/TheDefenders2017'':
** ''Series/JessicaJones2015'':
*** In the season 1 finale, Jeri Hogarth is implied to be a friend with district attorney Samantha Reyes, or at least, on good enough terms to address her by her first name. However, midway through season 2 of ''Series/Daredevil2015'', Foggy has a conversation with Marci Stahl, who has joined Jeri's firm since Wilson Fisk's arrest, and she mentions that Jeri and the partners are worried about Frank Castle's trial because if Reyes convicts him, she sets precedence for vigilantes like Daredevil and Jessica to persecuted as well. Marci implies that Jeri may have also had a falling out with Reyes as a result of the latter's attempts to persecute Jessica.
*** Jessica and Malcolm have a falling out in season 2 after a season of Malcolm getting shit upon and him [[DudeWheresMyRespect not feeling like he's getting the respect he deserves]].
** ''Series/Daredevil2015'': Elektra was Matt's college flame, and later his crimefighting partner for a bit in season 2. But then she is killed in the season 2 finale of ''Daredevil'', and when she's resurrected by the Hand, she's also now working for them, and even fighting against Matt, who she doesn't recognize. And even once she gets her memories back, she decides to still carry out the Hand's agenda.

[[folder: Music]]
* The Music/TheDandyWarhols song "We Used to be Friends" as mentioned above.
* Both "Believe Me" and "Where'd You Go" by Music/FortMinor are about this trope.
* Reliant K's "Which to Bury, Us or the Hatchet?" is ambiguous as to if it's a friendship or romantic relationship that's careening off the cliff, but the singer clearly doesn't like how badly things are breaking down.

[[folder: Professional Wrestling]]
* Quite common in professional wrestling, especially the WWE example of Wrestling/EddieGuerrero and Wrestling/ReyMysterioJr in 2005 comes to mind.
* The classic examples included Wrestling/HulkHogan and his feuds with "Mr. Wonderful" Paul Orndorff, Wrestling/AndreTheGiant and Wrestling/RandySavage. In both instances, a week after those two wrestlers turned heel on Hogan, Hogan would invariably come on and reflect on the now-broken friendship before accepting their challenge for his World Championship (or in the instance with Savage, demand a title shot against the champion "Macho Man").
* Also in 2005 were the Ballard Bros and Wrestling/CheerleaderMelissa, who had started off as their valet but ended up on the opposite of the ring with the All Pro Wrestling Rangers against their newer valet Luscious. The Ballards reminded her of their friendship and insisted they had no intention of fighting her, [[ILied but were lying.]]
* Wrestling/CMPunk was besties with Wrestling/PaulHeyman. Yeah, ''[[IFightForTheStrongestSide that]]'' [[ChronicBackstabbingDisorder Paul Heyman]]. When Paul inevitably betrayed him, Punk was beating himself up for grabbing the IdiotBall and not seeing it coming, as being his best friend he should've known that Pauly would sell out his own ''mother'' if he saw the writing on the wall.
* While Wrestling/RomanReigns took Wrestling/SethRollins's betrayal of Wrestling/TheShield hard, Wrestling/DeanAmbrose took it even ''harder''. Dean's only goal in life these days seems to be "beat the hell out of Seth Rollins", though it's very clear that beneath all the anger and hatred between them, Dean was genuinely hurt -- if this is anything to go by:
-->'''Dean''': [[AnguishedDeclarationOfLove I loved you Seth!]] You were my brother!
* Wrestling/{{Batista}} pulled this on Wrestling/ReyMysterio at the 2009 Bragging Rights after assuming Rey would automatically help him regain the World Heavyweight Championship. Batista would [[NoHoldsBarredBeatdown savagely]] [[FaceHeelTurn beat up]] Rey after Wrestling/TheUndertaker successfully retained the title.
-->'''Batista''': [[MemeticMutation You're supposed to be my friend!]]
* The inevitable betrayal of [[Wrestling/SamiZayn El Generico/Sami Zayn]] by [[Wrestling/KevinOwens Kevin Steen/Owens]] always leads to a feud like this. Because, at least to Steen/Owens, they are destined to be at war with each other ''forever''.

* Angels and devils in Literature/TheBible.
** Also {{God}} and [[{{Satan}} Lucifer]].

* ''Theatre/{{Rent}}'' - Roger, Collins, Maureen and Benny used to be tight when they were roommates, but when Benny moved out, bought their building and married Allison, a rift grew between them when it became clear he no longer thought the same way they did. Maureen hates Benny for "no longer believing in the same things." Mark and Roger hate him both for abandoning them after Roger got sick and for reneging on their deal. They all express themselves childishly. It's a stupid old world all around.
* ''Theatre/InheritTheWind'' features a scene where Henry Drummond and Matthew Brady, opposing counsels in the trial over evolution, meet and muse over their past friendship. It's stated that their differing views on religion caused them to party ways.
* Frank, Charlie and Mary had a tight friendship in ''Theatre/{{Merrily We Roll Along}}'' until Frank made it big and the other two interpreted it as selling out.
* How the eponymous ''Theatre/{{Hamilton}}'' feels about Aaron Burr, as demonstrated in "The World Was Wide Enough" [[spoiler:as the bullet from Burr's gun is heading towards him in slow motion]]:
--->'''Hamilton''': Burr, my first friend, my enemy - [[spoiler:perhaps the last face I'll ever see]].

[[folder: Video Games]]
* ''VideoGame/{{Persona 3}}'': Happened to Akihiko/Mitsuru and Shinjiro, though without the FaceHeelTurn. The three were the founding members of SEES, but after an incident in which Shinjiro's Persona went out of control, [[spoiler:killing Ken's mother]], Shinjiro distanced himself from the group, resulting in many bitter quarrels with Akihiko. Later in the game, Shinjiro rejoins the team, but things remain tense between him and Akihiko until [[spoiler:Shinjiro dies protecting Ken]].
** ''[[VideoGame/{{Persona4}} Persona 4 Golden]]'': Under the right conditions, namely [[spoiler:getting the Jester Social Link to Rank 6 before November 5 and then confronting the killer alone]], you can invoke this on the killer when their identity is revealed. The killer calls you out on your naivete and threatens to shoot you.
** Also from the fourth game, there's Chie's friendship with Takeshi, whom you meet on Chie's Social Link. Chie and Takeshi have known each other a long time, but Chie is somewhat uncomfortable with Takeshi's infatuation with Chie's best friend, Yukiko, and it's clear that Chie and Takeshi are more distant than they used to be. Later on in the link, though, during an argument over Takeshi's refusal to admit that he ran away from a gang of bullies, Takeshi notices how Yukiko has changed and become more openly cheerful, laughing at the strangest things, and accuses Chie of causing this. Chie angrily points out that this is Yukiko's real personality, and the two part on bad terms, never to be seen together again.
* ''VideoGame/SengokuBasara'': Maeda Keiji used to be friends with Toyotomi Hideyoshi before the latter got hit by a HumiliationConga at the hands of [[ManipulativeBastard Matusnaga Hisahide]], which made Hideyoshi DrunkWithPower and eventually led to him [[spoiler: killing his lover Nene]] and ended their friendship as a result.
* ''VideoGame/FinalFantasyII'': Firion, Maria and Guy with Leon. [[spoiler:Even at the end, after his HeelFaceTurn, he suggests that too much has happened for them to go back to the way they were before, but Firion holds out hope]].
* ''VideoGame/FinalFantasyVII'': Cloud and Sephiroth. Or at least that's how Cloud initially frames how they know one another. [[spoiler:In reality, Cloud and Sephiroth were never friends, but Zack and Sephiroth were and did act out this trope]].
** And in ''VideoGame/CrisisCore'' [[spoiler:Zack and Angeal in addition to Sephiroth and Genesis]].
* ''VideoGame/GrandTheftAuto'': Quite popular in the series. [[VideoGame/GrandTheftAutoIII GTA III]] featured Claude and Catalina, [[VideoGame/GrandTheftAutoViceCity Vice City]] features Tommy Vercetti and [[spoiler: Lance Vance]], [[VideoGame/GrandTheftAutoSanAndreas San Andreas]] has CJ and Sweet Johnson with [[spoiler: Big Smoke and Ryder]]. ''VideoGame/GrandTheftAutoV'' takes it up a notch by letting ''you'' turn against your friends. [[spoiler:At the end of the game, Franklin's life is on the line and he is forced to kill either Michael or Trevor to save his own skin. If you choose to kill Trevor, Franklin tries to justify his actions by saying how dangerous and psychotic Trevor was to everyone, which causes Trevor to blow up and say how he and Franklin used to be good friends to each other. Likewise, choosing to kill Michael will have him angrily blow up on Franklin, stating how he treated him like his own son and showed him how to make a big score. Franklin weakly justifies his actions towards Michael by saying he had it coming the whole time.]]
* Basically the plot of ''VideoGame/RedDeadRedemption'', where outlaw John Marston is forced by the government to track down and arrest/execute his old gang companions. He does try to downplay how close he was to many of them, especially since they've gotten progressively immoral since his departure, but it is clear he takes no joy in his job. [[spoiler: to drive spike further, the government agents send an army to take him out after he finishes.]]
* ''VideoGame/MetalGear2'': Solid Snake and Gray Fox. Not that they didn't still respect each other. There wasn't much ill will at the end of their climatic battle, either. [[spoiler:They patch things up further in ''VideoGame/MetalGearSolid''. Snake even still considered Fox a friend in one part of that game.]]
* ''VideoGame/MetalGearSolid4'': [[spoiler:Big Boss and Major Zero's We Used To Be Friends is partially the cause of the Metal Gear Saga. Over time, they went from close friends to the most bitter of enemies. Why? because they were both so arrogant in their opposing (wrong) beliefs about what their idol, The Boss, wanted for the world that they each [[StartOfDarkness went to extremes to fulfill their personal interpretations]], dividing The Patriots and causing Zero to create Solid and Liquid. Whilst at the end Big Boss no longer feels hate for his old comrade, it is far too late for them to repair their friendship as [[DownerEnding Zero's advanced age had left him a brain dead shell]].]]
* ''VideoGame/SkiesOfArcadia'': Fina and Ramirez.
* ''VideoGame/ResidentEvil4'': Leon and Krauser, where they aren't happy to see each other after several years since their last meeting. Their soured relationship is further explored in ''VideoGame/ResidentEvilTheDarksideChronicles'' where Krauser sustained a nasty injury on a mission with Leon and was forced to retire from his unit while Leon, who was a fresh government agent, got awarded for his actions in the mission. Krauser's retirement left him without a job and he became resentful towards Leon. When Wesker offered him a job as a mercenary, Krauser took the chance knowing that he would run into Leon eventually and extract revenge upon him.
* VideoGame/DeadRising: Frank eventually meets Kent, a fellow photographer whom he gets along quite nicely with. [[spoiler: Until Ken seems to crave a little too much for sensation.]]
* The Cousland family and [[spoiler:Arl Howe]] in ''VideoGame/DragonAgeOrigins''.
* Varric and Anders by the time of ''VideoGame/DragonAgeInquisition''. After Anders's atrocity at the end of ''VideoGame/DragonAgeII'', if Anders survived the final battle of that game, if asked, Varric bluntly states that he has no idea where Anders has gone, and frankly, he doesn't care either way.
* Shepard and the Virmire Survivor in ''VideoGame/MassEffect2''. Joining up with terrorists (no matter how noble your intentions) after [[LockedOutOfTheLoop apparently faking your death]] will do that. Especially when the leader of the terrorist group in question does not want your old friends anywhere near you.
** Worse at the start of ''VideoGame/MassEffect3'', although they're prepared to hear you out. Depending on whether you take the time to clear the air, they can end up [[spoiler: rejoining you, going to work with Hackett or dying at your hands. That last one's not too hard to avoid, though.]]
--> '''James Vega''': You know the Commander?
--> '''Virmire Survivor''': [[BrokenPedestal I used to.]]
* ''Franchise/AceAttorney'':
** Phoenix Wright and Miles Edgeworth were part of a PowerTrio with Larry Butz during the fourth grade after Miles and Larry were the only ones to stand up for Phoenix when he was accused of stealing Miles' lunch money. [[spoiler:It was Larry. When something smells, it's probably the Butz.]] Then Edgeworth switched schools after his father was murdered and switched career goals from defense attorney to prosecutor. Phoenix was inspired by Edgeworth and Butz to become a defense attorney himself, which led to a legendary courtroom rivalry between Wright and Edgeworth. They do become somewhat friends by the final case of the first game when Edgeworth actively helps Wright get the true killer of a case to confess.
** Happens with Lana Skye and the rest of the SL-9 investigation team. [[spoiler:Because she was blackmailed by Gant into fabricating evidence, and she became cold and distant as a result, Angel Starr and Jake Marshall became quite bitter toward her]].
** The fifth game gives a few examples, mainly in the third trial. Athena, upon being reunited with her childhood friend, Juniper, is surprised to see Junie acting coolly towards her. As the case goes on, it turns out that Juniper and two other students, Hugh and Robin, had also begun to split apart after being inseparable. [[spoiler:It turns out that this is all because a number of secrets, including Juniper acting as a spy to report wrongdoing in the school, Hugh learning his parents were bribing the teachers to improve his grades, and Robin actually being a woman,]] put so much stress on them that they became distant towards one another. They all reconcile by the trial's conclusion, happily.
* In ''VideoGame/DeadOrAlive'' Dimensions, a few scenes suggest this of [[CainAndAbel Kasumi and Ayane]], as flashbacks show the two playing together, and their mother, Ayame, tells Ayane that they used to get along quite well, and hopes they will again.
* In ''VideoGame/TalesOfTheAbyss'', Jade and Saphir (who now goes by the name Dist the Rose) are this trope, although Jade denies it and Dist claims to regret it ever having been true. [[spoiler:Their past association was broken when Jade chose to abandon fomicry due to personal and ethical concerns, while Saphir refused to stop trying to revive Professor Nebilim, considering Jade a traitor for giving up too soon.]] The party speculates they like each other better than either wants to let on, and it's usually PlayedForLaughs.
* In ''VideoGame/GuildWars2'' this is the current state of the (surviving) members of Destiny's Edge, the FiveManBand of LivingLegend s that takes up a lot of the backstory. The human member of the group abandoned them during a crucial battle to save his queen, which ended up getting one of their members killed. He is saddled with the brunt of the blame for what happened, but it also brings out and creates a lot of resentment for some members towards others, and they drift apart. Particularly tragic since the group was quite important in the whole overcoming racial barriers department. A large part of your characters personal story is based around getting the band to overcome the bad blood and get back to the whole saving the world from dragons business. ([[PerpetuallyStatic It is an MMO after all, obviously that task couldn't lay on your shoulders alone]].)
* ''VisualNovel/KatawaShoujo'':
** Lilly and Shizune, who are also cousins. Lilly joined the Student Council when most of the older members had left, but got into many arguments due to their personalities clashing (Lilly thought Shizune was too harsh and tyrannical, while Shizune thought Lilly was too unreliable). In Lilly's route, [[spoiler:the two reconcile shortly before Lilly is to leave Yamaku]]. In Shizune's route [[spoiler:Shizune admits that she was in the wrong.]]
** Misha is deathly afraid of this happening to her, Shizune, and Hisao. They're graduating high school soon and Misha is scared they'll go there separate ways and Shizune will eventually forget her. In the [[WhatCouldHaveBeen beta version]] this is a reason why [[spoiler:Misha is DrivenToSuicide]].
* In VideoGame/KnightsOfTheOldRepublic Revan and Malak used to be friends, till they were corrupted by the [[spoiler:Sith Emperor]]. Then the dark side of the force did the rest.
* ''[[VideoGame/ArmyOfTwo Army of TWO: The Devil's Cartel]]''. If you've played the game, you'll know. If you haven't, it's quite shocking.
-->'''[[spoiler:Rios]]''': ''I've changed my mind. I don't want to see that fucker's face again.''
-->'''Alpha''': ''You managed to even make [[spoiler:Rios]] hate you, you evil sack of shit''
* In ''VideoGame/{{Portal 2}}'', [[spoiler:Wheatley]] attempts to [[ExploitedTrope exploit]] this to make Chell stop running away from his DeathTrap. Being [[spoiler:Wheatley]], it's not very subtle.
--> "Aw. Just thinking back to the old days when we were friends. Good old friends. Not enemies. And I'd say something like 'come back', and you'd be like 'no problem!' And you'd come back. What happened to those days?"
* ''VideoGame/KingdomHearts'':
** Sora and Riku. Riku becomes a major antagonist after Maleficent manipulates him into believing that Sora doesn't care about him or his feelings for Kairi. He soon snaps out of it, and his friendship with Sora is restored. Of course, Sora never thought of Riku as an enemy, and [[spoiler: after he saves Kairi]], is determined to rescue him.
** Sadly played straight with Aqua to her friends Terra and Ventus. Aqua and Terra take the Mark of Mastery exam together, but only Aqua passes due to Terra losing control of the darkness within his heart. Eraqus gives the two of them a mission, which, for Terra, is a second chance to prove himself worthy, but also secretly tells Aqua to bring Terra back if he starts to succumb to darkness, and tasks her with finding Ventus when he goes after Terra. While Aqua tries to believe in Terra and even argues in his favor, she also becomes concerned about his actions, and Terra and Ventus [[WhatTheHellHero don't take it well]] when they hear about Aqua's mission. This dispute is never fully resolved for the rest of the game, but the friends continue to care for each other, to the point of being willing to sacrifice just about anything for each other.
** Also from Birth By Sleep, there's Master Xehanort towards Master Eraqus. The two were fellow Keyblade apprentices, but Xehanort injured Eraqus during an argument. Later on, there appeared to be some reconciliation when Eraqus willingly agreed to look after Ventus for Xehanort, [[spoiler:not knowing that Ventus had ended up that way as a result of Xehanort forcibly extracting the darkness from Ventus]]. Eventually, [[spoiler:Eraqus realizes that Xehanort is plotting something, and planning to use Ventus to make the X-blade, so Eraqus tries to kill Ventus, resulting in Terra fighting and defeating Eraqus and Xehanort finishing Eraqus off]].
** Axel and Saïx, back when they were Lea and Isa. As they grew up and became Nobodies, Saïx became crueler [[spoiler:due to Xehanort's GrandTheftMe]] and Axel befriended Roxas and Xion instead. This all comes to a head in ''3D'', where [[spoiler:Isa has been completely taken by Xehanort and attacks Lea without hesitation at the climax of the story.]]
* ''VideoGame/TheElderScrollsVSkyrim'': Ulfric Stormcloak, Galmar Stone-Fist, and Legate Rikke were once friends who fought together in the war against the Aldmeri Dominion. In Skyrim's Civil War, however, Ulfric and Galmar lead the Stormcloak rebellion and Rikke works with the Imperial General Tullius to put said rebellion down. There is no happy ending for them. If the Stormcloaks win, Ulfric and Galmar all but plead Rikke to surrender so they won't have to kill her, but [[LastStand she refuses]]. If the Imperials win, Rikke still hopes to the bitter end that Ulfric will see reason and surrender, but is forced to fight him and Galmar to the death when he also refuses.
* The Wizard and the King in ''VideoGame/{{Teslagrad}}'' used to be staunch friends and allies, but then the King began to abuse the powers the wizard had given him...
* In ''VideoGame/ShovelKnight'' the titular character and Polar Knight used to be friends. Both encourage the other to change allegiances before fighting, and even after his second defeat the Polar Knight still believes Shovel Knight should join the Order.
** There's also Black Knight. [[spoiler:Prior to the events of the game, they were in the same team as Shield Knight and Black Knight's attempts to hinder Shovel Knight were meant to prevent him from killing Shield Knight (who has become possessed by The Enchantress).]]
* Petra and Jinjur from ''VideoGame/EmeraldCityConfidential'' have this dynamic when the two part ways after their army days. Jinjur is bitter because Petra abandoned her post and duties during the Phanfasm War to find her missing brother. Petra is bitter because the Ozian royal guard never helped her search for him.
* Red and Blue from ''VideoGame/PokemonRedAndBlue'' were friends however as they grew they became rivals due to their similarities (same height, same age, etc). Future games depict them as having mended their friendship.
** Similar to this is Archie and Maxie from ''VideoGame/PokemonRubyAndSapphire'''s friendship before they split off into Team Aqua and Team Magma.
* In the finale of ''VideoGame/DmCDevilMayCry'', Vergil, Dante, and Kat stand atop the ruins of the collision between Limbo and the real world, having just ousted Mundus and his demonic grip on society. [[spoiler:It is at this time that Vergil reveals all you have been fighting for is so he can take the throne from Mundus and begin his own new world order to subjugate humans. Dante and Kat are shocked and outraged that they just killed an emperor only to crown a new one and Dante steps up to make sure that doesn't happen. Vergil is genuinely surprised that Dante wants no part of his vision and the two come to blows]].
-->[[spoiler:'''Vergil (after defeat)''': I loved you, brother...]]
* One Sunken Scroll in ''VideoGame/{{Splatoon}}'' reveals that [[spoiler:the Inklings and the Octarians used to have friendly relations before the Great Turf War broke out over a lack of livable territory. Specifically, it shows a younger [[BigGood Cap'n Cuttlefish]] hanging out with a humanoid Octarian who appears to be [[BigBad DJ Octavio]].]]
* ''VideoGame/NuclearThrone'' has this between Rogue and Li'l Hunter. They used to spend a lot of time together in the IDPD, but at some point Li'l Hunter was sent on a mission alone, failed it, and was summarily abandoned by the IDPD. Some SanitySlippage later and he now no longer remembers Rogue, but she still remembers him.
* ''VideoGame/MinecraftStoryMode'': Something happened between Ellegaard and Magnus when the Order split up, and they're not happy to see each other when the party reunites in the second episode.
* Undyne in ''VideoGame/{{Undertale}}'' will strongly feel this way if you befriended her and then kill someone afterwards. The only reason she accepted your friendship in the first place is because you spared her and then went out of your way get to know her, even though she tried to kill you because you were a human. [[spoiler: Undyne's king, Asgore, needing human souls to free all monsters was also part of the reason why she was hostile towards you.]] Killing ''anyone'' after befriending Undyne has her stop being your friend and, according to Papyrus, would utterly destroy you if you ever showed your face in her neighborhood ever again.
* Knoth sees Val this way in ''VideoGame/OutlastII''. Val was once one of the SinisterMinister's cultist followers until she broke free and formed TheRival heretics. Although she swears them enemies and sent him an insulting letter, Knoth still has a willingness to forgive her for this.
* ''VideoGame/InjusticeGodsAmongUs'' sees an alternate Superman fall to the dark side after the Joker drugged him and tricked him into killing Lois Lane--which in turn destroyed Metropolis as the Joker hooked up a nuke to her heart and Batman forming a reisistance after most of the League decided to join Superman in taking over the world. However, Bruce does regret how things went, and [[VideoGame/{{Injustice 2}} the sequel]] shows the feeling is mutual.
* Strider Hiryu and Strider Hien has this relationship in ''VideoGame/{{Strider}} 2'': they were close friends who worked several missions together in the Striders, until Hien [[FaceHeelTurn got seduced by the dark side]] and turned to the [[BigBad Grandmaster's side]], assisting his forces into [[GenocideFromTheInside wiping out the Striders entirely]]. Hien still considers Hiryu a friend, however, and after their first fight he tries his best to convince Hiryu that his mission is ill-fated from the beginning and to just forget it, but Hiryu simply turns him down and advises him to fight at his best next time. By their second (and last) encounter, Hien wastes no words and fights him all-out.
* ''VideoGame/MoshiMonsters'': Elder Furi (a wise old monster) and Dr Strangeglove (the main villain) used to be friends until they graduated university, at that point Strangeglove [[FaceHeelTurn turned evil]].
* ''VideoGame/FalloutNewVegas'': This is the general sentiment between Boone and Manny, two former First Recon Snipers, who moved to Novac to start a new life together, after leaving the army, but had their friendship tested, do to disdain between Manny and Carla, Boone's wife, possibly do to [[StraightGay Manny's]] [[LoveHurts own feelings for Boone]]. This came to a head when Carla went missing under mysterious circumstance and Boone realized Manny was ''happy'' his wife was gone. By the time the player comes across them in Novac, they are understandably, not on speaking terms.
* In ''VisualNovel/IkemenSengoku'', Shingen used to be best friends with [[spoiler:the monk Kennyo]] but the latter broke off their friendship after [[spoiler:being DrivenToVillainy by Nobunaga burning down his temple and [[HeWhoFightsMonsters becoming even more ruthless than him in the process]]]]. Shingen still harbors hope that they can become friends again someday, but the other man considers himself too far gone for that and would rather not have Shingen see him like this if possible.

[[folder: Web Animation]]
* ''Machinima/RedVsBlue'': [[AntiHero Agent]] [[{{Deuteragonist}} Washington]] and [[spoiler: [[BigBad the]] [[HeroKiller Meta]]]]. Season 9 revealed that they were closer to each other than really any other Freelancer.
* ''WebAnimation/MysterySkullsAnimated'': After returning as a vengeful ghost Lewis feels this way about the rest of the Mystery Skulls, especially Arthur who murdered him. It's unknown whether Lewis knows that Arthur was possessed at the time.

[[folder: Webcomics]]
* ''Webcomic/BittersweetCandyBowl'': [[spoiler: Mike and Lucy,the two main characters, are officially this as of Chapter 96. They were actually friends (and crushes) for the first half of the comic, but come Mike's TheReasonYouSuckSpeech to Lucy in December, he officially cuts off ties with her. He later comes to regret it when Lucy attempts suicide in Breaking Up and tries to apologize to her (not so much to rebuild their friendship as to show regret for taking it too far) when she comes back from being put on a bus between that chapter and Love Again, only for Lucy to make clear that she no longer wants any ties with Mike.]]
* Retroactive example in ''Webcomic/{{Homestuck}}'': Vriska actually used to be pretty close to Aradia and, in particular, Terezi, but after she started going too far and becoming Chaotic just for the sake of it, both turned their backs on her, their relationship irretrievably broken. Even later when Terezi remembered their friendship and wished they could return to it she couldn't pretend that Vriska wasn't evil or that she wouldn't work against her if it was necessary.
** Gamzee and Karkat were moirails after Karkat pulled him out of his murderous rage. During their isolation on the meteor, Karkat makes a point that he won't reveal where Gamzee is, and Gamzee admits to wanting to keep [[spoiler: his relationship with Terezi]] secret because he fears for their friendship. When they finally get to the Post-Scratch Kid's session, their relationship has fallen apart because Gamzee didn't hold up his end. When they meet up again on LOFAF and Karkat sees him [[spoiler: viscously beating Terezi]], [[http://www.mspaintadventures.com/?s=6&p=008742 he makes it clear that Gamzee's gone too far]].
* In ''WebComic/EvilPlan'' Stanley [[spoiler:Kinesis (back in college)]] and William sever ties after [[spoiler:a fight about the telekinetic chip.]] Possibly subverted, as it was recently revealed [[spoiler:that they're still on speaking terms. Why this is has not yet been explained.]]
* In ''ComicBook/SonicTheComic'' Sonic and Amy were friends but in the fan-sequel ''Webcomic/SonicTheComicOnline'', after the Kane arc, Sonic and Amy have become enemies (although it is implied Amy still trusts Sonic on some level, it's just impossible to be sure about him given the circumstances).
* In ''Webcomic/GirlGenius'', Gilgamesh and Tarvek became close friends while growing up on Castle Wulfenbach. Their bond is ruined when Tarvek gets sent home for spying, after being told on by Gil- when in fact Gil was his partner in crime, and the secret they were after was the truth of Gil's origins. In the present day, they [[BettyAndVeronica vie for]] Agatha's affections. Gil views Tarvek as a "weasel" and an ineffectual dandy; Tarvek, for his part, sees Gil as a libertine cad.
** Played with - for all that they insult, snark at, and oppose one another, it's quite apparent that the two still grudgingly respect, and even like, one another a great deal. Those members of the fanbase who support [[OneTrueThreesome a certain inclusive conclusion]] to the comic's LoveTriangle point to these moments of AwLookTheyReallyDoLoveEachOther as potential support.
* Mr. Blank and Mr. Black in ''Webcomic/SamAndFuzzy'' used to be the two best [[{{Tykebomb}} Blankfaces]] of the Ninja Mafia until Sam (unwittingly) caused its downfall. Blank stayed loyal, Black decided to use his newfound freedom to sell his skills on the open market and tries using his successes to convince Blank to follow his example. [[spoiler:He fails. Fatally.]]
* ''Webcomic/TowerOfGod'': Baam and [[spoiler:Rachel]]. In this case, it doesn't end well, and the falling out started before Baam even realized it: [[spoiler: The moment he followed her into the Tower.]] In the end, she drowns him and he barely survives, crushed by the fact that [[spoiler: his only family, friend and possible lover]] now hates him, where the only thing he truly feared was being alone.
* In ''Webcomic/{{Consolers}}'', Nintendo and Sony used to work together on a SNES add-on and were pretty decent friends... [[spoiler:until Nintendo finds out Sony rewrote the contract to get most of the profits himself.]] She ends up cancelling the deal (in front of a huge audience), Sony makes his own console as revenge and they become industry competitors.
* Part of the premise of ''Webcomic/{{Crepuscule}}'' is how Lark and Setz were once each other's (only) friend, but after Setz abandoned Lark ([[InternalReveal for understandable reasons that Lark doesn't learn for a while]]) and they spent ten years with no contact while Setz TookALevelInJerkass, things are obviously rather tense between them now, with Setz too withdrawn to explain his actions and Lark no longer caring about him. Thankfully, they patch things up. [[spoiler:And then Lark TookALevelInJerkass to even bigger extremes, with Setz pulling this card this time--and again, at the end of that season, they mend their friendship.]]
* ''Webcomic/ZebraGirl'': The bonds between the group are heavily damaged when [[spoiler:Sandra turns on them, forcing Jack to banish her to another reality. During her stay in the Subfusc, Sandra is able to regain her morality and feels remorse for her actions, but she doesn't expect them to forgive her for what she did. Years later, when her former friends hear about her return, they are terrified (except Crystal, who still has hope that Sandra will go back to her former self, though she admits herself that she is at her limit).]]
* ''Webcomic/TheLegendOfSpyroZonoyasRevenge'': Cynder and Zonoya used to be best friends until Cynder became cursed, scratched Zonoya's eye and drove her away.

[[folder: Web Original]]
* In ''Roleplay/TheGamersAlliance'', [[DemonLordsAndArchDevils Vaetris]] and [[MamaBear Jahi]] were once prostitutes in the Demon Realm and close friends, but things changed when they were abused too much and Vaetris's ambition to change their living conditions turned her to the path of conquest, bloodshed and manipulation whereas Jahi chose to nurture her young instead, which set the two on different paths. [[NobleDemon Ronove]] and [[ThePaladin Nesa]] became friends while the former was amnesiac but once Ronove regained his memories of being a demon lord, he took back his position in the demon hierarchy and ultimately betrayed his friends, Nesa included. However, both cases are more complex and grey than that and have shades of FriendlyEnemy because neither Vaetris nor Ronove act in a truly villainous way and they do seem to care for their former friends somewhat whenever they're dealing with them although in both cases manipulation is also involved.
* In ''Series/{{Noob}}'', Arthéon mentions that his former guildmates are snubbing ever since he got his high-level avatar banned for RealMoneyTrade. Saphir was okay speaking to him in Season 1 (but not helping him finish the quest needed to get a sword), while Ystos is still friendly to him. Fantöm was explicitly not aswering his e-mails in Season 1 [[spoiler:, but is back to speaking terms with him after Season 3 due to circumstances putting them in the same guild]].
* In the web-serial ''Literature/AshAndCinders'' Orym and Thavian were both Wizards, both trained under the same master, and are brothers. For some an-yet unspecified reason, had a falling-out that's led at least two known nearly-lethal encounters.
* In the web novel ''Literature/{{Worm}}'', Taylor and Emma's childhood friendship ended after Emma ends up being attacked and, seeking to change her world views, cuts ties with Taylor and starts bullying her.
* WebVideo/TheNostalgiaCritic and Santa Christ. A lot of it is due to Critic fucking up (like accidentally shooting Santa Christ in ''WebVideo/{{Kickassia}}''), but there's also Santa Christ taking a level in jerkass.
* ''{{WebVideo/Aaron}}'' deals with two brothers who were once good friends, but drifted apart and are now estranged.

[[folder: Western Animation]]
* The BackStory of the ''WesternAnimation/StormHawks'' had [[TheDragon The Dark Ace]] as friend and co-pilot to the original Storm Hawk's captain. He's the reason why the original Storm Hawks [[BackstoryHorror are all dead]].
* In ''WesternAnimation/{{Gargoyles}}'' this occurs between Macbeth and Demona, as seen in "City of Stone": best of friends when they first fought together against Duncan and won Macbeth his kingdom, things go south when Demona, mistakenly believing that Macbeth was about to betray her and her clan, betrays him first, causing him to lose his kingdom, family, and identity.
* Occurs in the second ''[[WesternAnimation/TeenageMutantNinjaTurtles2003 Teenage Mutant Ninja Turtles]]'' cartoon between Leonardo and the Shredder's adopted daughter Karai, who in previous seasons had developed a rapport of sorts with him, despite their FeudingFamilies. When the turtles successfully stop the Shredder's plan [[spoiler: to leave Earth to conquer the Utrom homeworld, and end up getting him imprisoned and exiled]], Karai takes it as a betrayal, and vows to avenge her father. Later, after Karai [[spoiler:destroys the turtles' lair and believes she's killed the other turtles and Splinter]], she heads into April O'Neil's shop and asks her to give Leonardo a message. When April asks Karai (whom she's never met before) how she knows the turtle, she responds with the trope name.
* Plankton and Mr. Krabs of ''WesternAnimation/SpongebobSquarepants''. They used to be close friends but are now mortal enemies because of the Krabby Patty formula.
* ''WesternAnimation/AvatarTheLastAirbender'' reveals that Aang's predecessor Avatar Roku used to be best friends (with a lot of HoYay) with Firelord Sozin, the man who started the [[TheEmpire Fire Nation's]] war for world domination, and committed genocide against the airbenders.
* ''WesternAnimation/MyLittlePonyFriendshipIsMagic'':
** The Alicorn sisters Princess Celestia and Princess Luna used to jointly rule Equestria together until Luna became bitter and resentful when their subjects favored Celestia over her, turning her into Nightmare Moon. After Luna is defeated and returned to normal centuries later, however, the two sisters reconcile.
** Rainbow Dash and Gilda in "Griffon the Brush Off". They used to be childhood friends, but their friendship is broken off after Dash finds out that Gilda has been bullying her other friends behind her back. This bitterness carries over into their reunion in "The Lost Treasure of Griffonstone", though Pinkie Pie proves that Gilda has a [[JerkWithAHeartOfGold heart of gold]] and helps them make up in the end.
** Discord attempts to invoke this in the two-part season 2 premiere "The Return of Harmony" in order to keep them from using the [[ThePowerOfFriendship Elements of Harmony]] against him, using a combination of [[{{Brainwashed}} mind control]] and [[MoreThanMindControl mind tricks]] to get Twilight's friends to behave opposite of their respective elements. [[NearVillainVictory He very nearly succeeds]] in pushing Twilight over the DespairEventHorizon with her corrupted friends, but Twilight overcomes his mind games with help from her old friendship reports and lifts his spell on her friends to take him down.
** In "Amending Fences", Twilight is shown to have drifted so far apart from her old friends at Canterlot that she can't even remember their names. As soon as this dawns on her, [[MustMakeAmends she immediately sets out to fix things]]. While most of them are [[TurnTheOtherCheek willing and eager to reconnect]], her closest friend Moondancer wound up holding a deeply seated grudge because Twilight brushed off her one attempt to be more social and then left without saying goodbye, which caused Moondancer to isolate herself in her books and studies much like Twilight herself used to do. After Moondancer [[TheReasonYouSuckSpeech finally vents her pent up frustrations at Twilight]], the two patch things up.
* The King of Galaluna and Modula in ''WesternAnimation/SymBionicTitan''. Lance's WholeEpisodeFlashback shows them getting along amicably but most of the show is Modula [[DistressedDude holding the King hostage]]. The King is surprised when he discovers Modula was behind his planet's invasion.
* Jacob and Kane (along with Dr. Hudson, although he's not really a bad guy) in ''WesternAnimation/{{Motorcity}}''. Jacob now fights [=KaneCo=] with the Burners and helped design their bots, which gives him some inside knowledge.
* WesternAnimation/DaffyDuck gives WesternAnimation/BugsBunny mad ups in "WesternAnimation/PorkyPigsFeat." When they get paired up over ten years later, Daffy becomes the Iago to Bugs' Othello.
* In ''WesternAnimation/ScoobyDooMysteryIncorporated'', Scooby was on the outs with Shaggy, who he had discovered was romancing Velma, and with Velma in a jealous snit over Shaggy. Fortunately, fences were mended soon after.
* The ''WesternAnimation/TinyToonAdventures'' episode "Citizen Max" shows Buster and Montana Max used to be the best of friends when they were younger, they shared whatever they had because Max was poor, then his parents won the lottery and Max became a selfish, greedy jerk and cut off his friendship with Buster
* ''WesternAnimation/CodenameKidsNextDoor'': The second-to-last episode of the show, "Operation: T.R.E.A.T.Y.", shows that Numbuh 1 and the former Numbuh 274, Chad Dickson, used to be quite close. Chad had apparently mentored Nigel back when he was a cadet, and Nigel was close enough to him to call him "old friend". Thus, Chad's betrayal was a cut so deep that the two developed a huge rivalry that lasts the rest of the series. It eventually boiled down to this episode, where a ChainedHeat situation strains their already tenuous relationship to the breaking point, and by the end, they're trying to kill each other. [[spoiler:Even after it's revealed that Chad was a FakeDefector, his disappearance afterwards and his behavior throughout the episode makes it evident that the bridge is burnt and that there's no salvaging their friendship]].
* ''WesternAnimation/BraceFace''. Sharon and ArchEnemy Nina Harper used to be real good friends until the second grade, when someone mysteriously chopped off the heads of Nina's dolls and she blamed it on Sharon.
* The ''WesternAnimation/StevenUniverse'' episode "Maximum Capacity" reveals that Greg and Amethyst used to be good friends who enjoyed watching tapes from an old sitcom together. Their relationship is more strained now due to Amethyst's resentment over Greg monopolizing Rose Quartz's attention when they started their relationship and Greg spending less time with Amethyst as a result (leaving her feeling even more alone). Greg admits he would like them to be friends again, but not if it means he has to put up with her hurtful behavior.
* ''WesternAnimation/BoJackHorseman'':
** In Season 1, [=BoJack=] and Herb Kazzaz. The latter never forgave [=BoJack=] for not coming to his aid when he was blacklisted from the entertainment industry [[spoiler:for being gay.]]
** Season 3 ends on a particularly friendless note for [=BoJack=]. [[spoiler:Todd has had it with [=BoJack=]'s selfish, self-destructive behavior and gives him a TheReasonYouSuckSpeech in the third-to-last episode of the season. [=BoJack=] has fired Princess Carolyn as his agent. Things are weird between him and publicist/occasional lover Ana Spanakopita. Add to his former co-star/friend/sometime lover Sarah Lynn overdosing in his arms in the second-to-last episode, and [=BoJack=] is in a really bad way as far as friendships go.]]
* ''WesternAnimation/GravityFalls'': [[spoiler:Ford]] used to be close friends with both [[spoiler:Bill and his brother Stan]] but external circumstances have him end up falling out with the two. With the former, [[spoiler:Bill]], it broke after[[spoiler:Ford]] realized that he had been betrayed when [[spoiler:Bill]] only used him to create a portal to enter Gravity Falls and remake the world in his image. For the latter, [[spoiler:his brother Stanley]] ended up accidentally ruining his chance to go to the college of his dreams. As a result, [[spoiler:Ford]] disowns him along with his father, and only contacts him over ''12 years later'' to perform a menial task (one he even claimed would be ''the first worthwhile thing [[spoiler:Stanley]] had done in his life'') in an attempt to fix his own mistakes- even when he'd refused to help [[spoiler:Stanley]] with the fallout of his own. Even into the present, he demands that [[spoiler:Stan]] give him back his house & identity back, close the Mystery Shack for good, and leave, effectively mutually disowning each other as brothers in the process to the point that one even outright declares the kids to be the only family left to his brother's face and the latter doesn't even argue against it.
* In ''WesternAnimation/{{Recess}}'', T.J. and [[spoiler:[[TeachersPet Menlo]], of all people]] used to be friends. [[spoiler:However, even though they don't hang out anymore, they made an agreement that T.J. would come to Menlo's birthday party every year.]]
* ''WesternAnimation/TangledTheSeries'' has a rather sad example between Rapunzel and [[spoiler: Varian]]. [[spoiler: The [[{{Adorkable}} clumsy]] Varian]] started out as a close friend of Rapunzel's and provided a lot of help for her, Eugene, and Cassandra with [[spoiler: his inventions]]. Then came the episode "[[WhamEpisode Queen For a Day]]", which marked the downward spiral of his and Rapunzel's friendship: [[spoiler: Varian inadvertently causes [[WellDoneSonGuy his father]] to start getting encased in crystal. In a panic, Varian travels to the castle of Corona only to find Rapunzel and the others with too many other problems on their laps (a cataclysmic snowstorm is threatening to tear Corona apart and her parents are missing) to just drop it all and help Varian out. Varian comes back to find his dad completely encased in crystal and, [[DespairEventHorizon in his anguish]], blames Rapunzel for not coming to help him. By the end of the season, Varian has slowly but surely severed almost all ties between not only Rapunzel but the entire kingdom (to the point of kidnapping the Queen), and Rapunzel is clearly hurt by this by the end of "The Alchemist Returns", admitting she "[doesn't] even know what he is anymore". Rapunzel, however, still has hope that the friendship could be salvaged, given that she asks for Varian to be treated with care and given the help he desperately needs following his arrest. Only time will tell if Varian will eventually have that HeelRealization and make up with Rapunzel.]]

[[folder: Real Life]]
* ''Literature/ToKillAMockingbird'' author Harper Lee and Truman Capote. Capote was jealous that Lee won a Pulitzer right off the bat with her first book, and that he never won one despite being a famous and acclaimed author in his own right.
* Vercingetorix and UsefulNotes/JuliusCaesar, if the latter is to be believed.
** Also with Ceasar and Pompey the Great. Caesar actually still considered Pompey a friend during the Civil War between them and genuinely grieved at Pompey's brutal murder. Likewise, Caesar and Brutus. He spared the latter for siding with Pompey, and was supposedly quite shocked when the latter stabbed him.
* Pete Doherty and Carl Barât of Music/TheLibertines were estranged after the band's breakup in 2004 before reconciling in 2009, leading to the band's one-off reunion a year later followed by a permanent reunion four years after.
* It's always well publicised and seems particularly poignant when two musicians who are songwriting/performing partners and/or relatives fall out. Examples include [[Music/TheBeatles John Lennon and Paul McCartney]], [[Music/SimonAndGarfunkel Paul Simon and Art Garfunkel]], [[Music/GunsNRoses Axl and Slash]][[note]] (Axl and Slash reconciled in 2015, ending their 19-year rift with Slash rejoining the band a year later along with Duff [=McKagan=])[[/note]], [[Music/TheBand Levon Helm and Robbie Robertson]], [[Music/TheKinks Ray and Dave Davies]], [[Music/TheSmiths Morrissey and Johnny Marr]], [[Music/{{Oasis}} Liam and Noel Gallagher]], and Burt Bacharach and Hal David.
** And on this topic, Music/SydBarrett and the rest of Music/PinkFloyd. Syd Barrett left the band due to his increasing mental and psychological problems, and [[ReclusiveArtist eventually withdrew himself from society all together]]. Years later, Syd Barrett visited the band in the studio while they were recording their latest album. However, they didn't recognize him at first due to his having gained weight and shaved off his eyebrows and hair, and when they did eventually recognize him, it caused Creator/RogerWaters and Richard Wright to be reduced to tears. And the song they were recording at the time? "Shine On You Crazy Diamond", which was their tribute to Syd, ''and he didn't know that it was about him''. Aside from an encounter with Waters at Harrods a few years later, this would be the last time the band saw Barrett until the day he died.
* Music/TheEagles:
** Don Henley and Glenn Frey wrote the title song to ''The Long Run'' partially based on their strained friendship and how they were optimistic that they would work it out like they always do. The band (and their friendship) broke up for over a decade a year later, but reunited in 1993 until permanently disbanding in 2016 after Frey's death.
** When Eagles guitarist Don Felder refused to sign a deal that would give band leaders Frey and Henley a much larger share of band profits, that resulted in his firing from the band in 2001, and alienated him from everyone else in the band, including the laid-back Timothy B. Schmit and Joe Walsh. He remains friends with ex-Eagles Bernie Leadon (dating back to their high school days in Florida) and Randy Meisner, though.
** To be fair, Felder had long had a contentious relationship with Henley and Frey, and was the target of the latter's ire during the Eagles' last gig in 1980 before their 13-year disbandment -- a benefit gig for Senator Alan Cranston where Frey was audibly threatening Felder ''during'' the set.
* Before UsefulNotes/GenghisKhan was Genghis Khan, he was Temüjin, and he was best friends since childhood with a boy named Jamukha. Eventually, Jamukha was declared a Khan himself. Temüjin refused to accept this, and the two who had been as brothers went to war with one another, with Temüjin being victorious due to his more progressive methods and tactics, along with Jamukha's forces betraying him. After [[RewardedAsATraitorDeserves rewarding the traitors]], Temüjin offered the defeated Jamukha a place by his side so that they could resume their friendship, but Jamukha declined with the following speech:
-->'''Jamukha:''' "What use is there in my becoming a companion to you? On the contrary, sworn brother, in the black night I would haunt your dreams, in the bright day I would trouble your heart. I would be the louse in your collar, I would become the splinter in your door-panel... as there was room for only one sun in the sky, there was room only for one Mongol lord."
** Then he asked to be killed without having his blood spilled. Temujin's soldiers broke his back. To be fair, being killed without having your blood spilled was the Mongol way to show respect for royalty. Jamukha asked to die as a Khan, and Temüjin [[WorthyOpponent complied]].
* Paris Hilton and Nicole Richie were an ubiquitous duo in the early 2000s until they had a public falling out sometime after filming the third season of ''The Simple Life'', necessitating the fourth season to adopt a new format so the two could be filmed separately. They returned to speaking terms and shot the fifth season together, but never returned to being the friends they once were.
* UsefulNotes/SigmundFreud and UsefulNotes/CarlJung, as seen in ''Film/ADangerousMethod''. After a few years as colleagues, Jung tried to convince Freud that focusing purely on the sexual roots of human motivation was too limiting and that religion wasn't entirely bunk. He believed that the subconscious is not so much the repository of repression as it is the wellspring of creativity. He also promoted the idea of the ArchetypalCharacter, and that many actions are based on patterns that tend to repeat themselves. Freud disagreed with him as well as what he considered Jung's lack of professionalism[[note]]Jung had a sexual relationship with one of his patients, Sabina Spielrein, then mentored her in a TeacherStudentRomance, and worst of all, in Freud's eyes, lied to him about it by slandering Spielrein[[/note]] and that ended their friendship.
* Creator/AlbertCamus and Creator/JeanPaulSartre were friendly for a span of 6 years between 1944-1952. They split because Camus became a die-hard anti-communist while Sartre was sympathetic to Marxism, and critical of capitalist nations in the Cold War. The split became political when Camus supported French colonialism in Algeria, which Sartre opposed, while the latter refused to say one word against the USSR's policies between 1952-1956, much to Camus' anger.
* Creator/FriedrichNietzsche and Music/RichardWagner. Nietzsche even wrote two books explaining his perspective: ''The Case of Wagner'' to mark his break, and ''Nietzsche contra Wagner'' to explain how his thoughts on music had been consistent, but his earlier application of them to Wagner had been incorrect.
* Shaquille O'Neal and Kobe Bryant were never friends. At best they tolerated each other for the sake of winning championships. Things eventually got to the point that even this wasn't possible.
* Creator/HarryHoudini and Creator/ArthurConanDoyle were very good friends who bonded over a shared interest of the Occult, Spiritualism to be exact. The two would go around looking for people who claimed to be psychics or mediums or witches, etc, but where [[AgentScully Houdini]] was an Open but heavy Skeptic who believed everything to be fake until proven otherwise, [[AgentMulder Doyle]] tended to believe everything at face value (ironic). The two eventually went different ways after Houdini declared Doyle's wife, who claimed to be a Ghost writer, a fake.
* Creator/DavidLetterman and Creator/JayLeno. Leno helped inspire Letterman to try comedy, then Leno became one of Letterman's early supporters. Then Leno was Letterman's most frequent guest during the early years of ''Late Night'', which boosted Leno's profile and led to him becoming Creator/JohnnyCarson's fill-in host. Then Carson retired and Creator/{{NBC}} picked Leno to replace Carson, a job that Letterman considered himself the heir-apparent for.
* Lil' Kim and Music/NickiMinaj used to be on good terms, believe it or not. Nicki Minaj used to give a shout out to her in interviews as a inspiration, and there are pictures of them smiling and putting their arms around each other at a concert. Minaj also said she was a die hard fan of Kim as a kid. Then, for reasons ambiguous, they became enemies and wrote various songs targeted at one another defaming the other, and calling each other ''very'' profane words. They still put references to how much the other one sucks in their mix tapes, and are sure to bring the other one up in the interviews even when not asked.
** Also, Minaj is no longer friends with Creator/MariahCarey after ''Series/AmericanIdol''.
* This probably happened to anyone who used to be friends with someone but can no longer be as such due to betrayal, betrayals, general growing apart, personal growth or lack there of or a similar event or EVENTS.
** Or to [[AllLoveIsUnrequited love from a friend to the other not being returned]].
** Never mind the friends who just stop hanging out after graduation or leaving a place of often hanging out/being there, like School, College, Uni, other educations and all work places.
* Unfriending/Unfollowing
** No longer being in the same city/state/country/school, falling out that way...
* Another notable historical example was William Marshal, known for actually keeping to his word in an era of political expediency. He followed Henry II's eldest son, then followed Henry II, even when Richard (the Lionheart) rebelled against his father. The trope comes in due to William tutoring Richard and even being good friends, yet they came face to face during the retreat of King Henry's army. William Marshal, owing to being perhaps the most skillful warrior in Christendom at the time, was able to kill Richard's horse and let the man live.
* In another historical example involving the Plantagenets, this was almost certainly part of the reason the legendary feud between Henry II and Thomas Becket was so acrimonious (and ended so badly). The two were initially close friends; Becket's appointment was supposed to give Henry greater control over the Church in England. Instead Becket found he had a very real religious vocation and became a staunch defender of the rights of the Church against Henry, culminating in Becket's brutal murder at the unwitting instigation of Henry. It's made all the more poignant by the fact many accounts state Becket explicitly begged Henry *not* to appoint him Archbishop of Canterbury because he feared this was precisely what would happen. Henry was in fact devastated by Becket's death, and became one of the earliest and most fervent believers in his saintly cult.
* UsefulNotes/JohnFKennedy and UsefulNotes/RichardNixon were friendly while serving in Congress together. Kennedy reportedly donated money to Nixon's 1950 Senate campaign, and the two retained offices across the hall from each other after Nixon became Vice President. The presidential campaign in 1960 ended their friendship; Nixon felt especially angry that when he was hospitalized, Kennedy neither visited him nor suspended his campaign. For Nixon, this mutated into near-pathological hatred of not only JFK but his brothers as well.
* Creator/WilWheaton and Creator/RiverPhoenix became friends after starring together in ''Film/StandByMe'', but their friendship fell apart as Phoenix developed drug problems which would sadly end his life.
* During UsefulNotes/TheAmericanRevolution, the friendships between the Founding Fathers often ebbed in the decade of Washington's first presidency.
** During the Revolution, Benedict Arnold was friendly with many of the key figures, and George Washington had commended him on several occassions, but because of political factors, Arnold never got a promotion commensurate to his achievements despite winning the crucial Battle of Saratoga (which convinced the French that the Patriots ''could'' win if they got additional support). After the Revolution, UsefulNotes/ThomasJefferson and Washington (who were never quite close) maintained cordial relations that ended when Jefferson wrote a critical article on Washington in a newspaper under a pseudonym. Washington was quite cool with Jefferson after that.
** The most spectacular example is of course the MeleeATrois of Aaron Burr, Jefferson, and UsefulNotes/AlexanderHamilton. Burr and Hamilton were friends, they worked in law practice together, and were both New Yorkers. But sometime during the 1790s their friendship cooled and Burr became friendlier with Jefferson, who hated Hamilton. Then in the (hopelessly flawed) 1800 election, circumstances[[labelnote:*]] (in those days, electors cast two ballots – the winner would be President and the runner-up would be Vice President – the Framers in 1787 did not anticipate organized political parties; this meant 1800 was legally a four-person race, and no one got a majority so the election was thrown to the House, controlled by a lame-duck Federalist majority who wanted to stick it to Jefferson by voting for Burr once John Adams was eliminated)[[/labelnote]] resulted in Burr – ostensibly Jefferson's running-mate – nearly winning the top job himself, but was denied as a result of Hamilton's influence.[[labelnote:*]] Yes, Hamilton still hated Jefferson, but he also thought Jefferson was "by far not so dangerous a man". In other words, better to have a man with wrong principles than one devoid of any.[[/labelnote]] When Burr later ran for Governor of New York, Hamilton published an ad in a newspaper that triggered the famous Burr-Hamilton duel, that led to Hamilton's death. Much later, Jefferson parted ways with Burr when he charged him with treason for a land-grabbing scheme. The trial found Burr innocent but the matter of the case and the smear campaign which Jefferson arranged ruined that friendship too.
** Jefferson and John Adams were a zigzagged example. Close friends during the Revolution, their divergent political philosophies, starting when they both served in Washington's administration, drove them apart to the point they founded rival parties against each other. However, after they retired from politics, they reconciled their differences, and by the time of their deaths (on the same day), they were the closet of friends again.
* This became much more deadly during UsefulNotes/TheFrenchRevolution where close friends who once allied on common points became polarized as a result of political factionalism and eventually sent each other to the guillotine. The most famous and tragic example is that of UsefulNotes/MaximilienRobespierre, Georges Danton, and Camille Desmoullins. Robespierre and Desmoullins went to school together, Desmoullins and Danton practised law together and Robespierre and Danton allied on many key issues. Then during the ReignOfTerror, Robespierre after initially supporting Danton and Desmoullins for several months, turned on them after a corruption scandal was unearthed and sent them both to the guillotine. Danton issued a DyingCurse to Robespierre on the way to the guillotine.
--> '''Georges Danton''': You'll follow us shortly, your house will be beaten down and salt sown in the place where it stood!
** On the Night when Robespierre met his downfall, one of the Thermidorians invoked this, leading to Robespierre's final recorded exchange:
--> '''Man in Crowd''': ''"It is Danton's blood that is choking you!"''
--> '''Robespierre''': ''"Danton! It is Danton then you regret? Cowards! Why did you not defend him?"''
* UsefulNotes/VladimirLenin and UsefulNotes/JosephStalin are sometimes perceived as friends thanks to their Communist sympathies, and that eventually Lenin saw Stalin as too violent and wrote to UsefulNotes/LeonTrotsky to ask him to unite to try and get rid of Stalin.
** Stalin and Lenin's closeness is exaggerated by later media portrayals, and partly thanks to Stalin exaggerating his connection to Lenin. Lenin was personally quite aloof and kept himself apart partly because of TheChainsOfCommanding, and partly because he wanted to institute professionalism in leadership, where in Russia friendship and patronage reigned. Trotsky would later claim closeness to Lenin as well, but the two of them were closer to VitriolicBestBuds and Lenin was skeptical of Trotsky as well. Indeed Trotsky claimed to be a Menshevik who once castigated Lenin only to finally become the latter's NumberTwo during the Russian Civil War. Lenin for his part was friendly with some Mensheviks and he continued to admire George Plekhanov even after their friendship and association ended.
** What for Lenin was [[CrossesTheLineTwice crossing the line twice]] was that Stalin became angry at Nadezha Krupskaya, Lenin's wife, for updating Lenin in party-related manners when the doctors told him to rest. Lenin was receiving daily fake ''Pravda'' numbers with good news (the HBO movie ''Stalin'' portrays this incident), and Nadezha realized that Stalin was trying to isolate Lenin. Stalin confronted Nadezha [[JerkAss and insulted her, calling her a "whore"]], which ''really'' [[BerserkButton made Lenin upset]] and started a chain reaction that led to his secret block with Trotsky and his final Testament.
** Nikolai Bukharin and Stalin were allies during UsefulNotes/TheSovietTwenties, and Bukharin seemingly allied with Stalin against Trotsky and the Left Opposition, but eventually Stalin had him submitted to ThePurge. Bukharin wrote Stalin a note asking, "Koba, why do you need me to die?" before his execution; Stalin kept that in his desk drawer and it remained there till his death.
* [[{{UsefulNotes/China}} China's]] Communist Party seems to regard its nationalist counterpart headquatered in Taiwan in this way. The two parties have common origins as well as a long history of opposing the Japanese. In the overwhelmingly popular Mainland Chinese war dramas you'd be surprised how many positive characters are nationalists (who were admittedly much more active in the anti-Japanese resistance) rather than communists. It seems that the party line states the nationalists were a decent bunch that just got hijacked by the overly ambitious and capitalist-influenced Chiang Kai-shek shortly after the war, and even Chiang Kai-shek himself is seen more as a TragicVillain who just made the mistake of pulling off an ill-fated FaceHeelTurn (his wife, for instance, a patron of China's air forces, is widely revered as a war heroine throughout the country).
** It's also important to note that capitalists (or bourgeoisie) in China are not as vehemently hated as, say, they were in the Soviet Union since their attempt at bringing down the colonial rule by toppling the Imperial monarchy and later contribution to the anti-Japanese war effort are both well remembered and noted in the official history textbooks. In short, capitalism is not as much an enemy ideology as just one that didn't quite work out for China in spite of its good intentions, especially compared to socialism.
* During UsefulNotes/WorldWarII, Russia was one of America's closest allies against the Nazis. Then the war ended, and the USSR and US became ArchEnemies during the Cold War, often fighting proxy wars across the globe. In one of these proxy wars, America's top allies were groups of Islamist militants who fought the Soviets in Afghanistan. These militant groups went on to become Al Qaeda and the Taliban.
** Although it is worth noting that the US and the USSR were only really friends during the war. The Americans and Russians had treated each other as rivals at best as far back as the UsefulNotes/RussoJapaneseWar (which saw quite a bit of unofficial American assistance to the Japanese due in part to popular opinion about the pogroms suffered by the Jews in Imperial Russia).
*** Even during the war, they were harldy friends, other than in the 'enemy of my enemy' sense. The USSR used the opportunity to build up its spy-networks in the USA and the Americans were already shaping a post-war policy that would limit Soviet expansion, particularly in the pacific.
*** However, they ''did'' have their moments of genuine friendship, as UsefulNotes/FranklinRoosevelt and UsefulNotes/JosephStalin had a surprisingly warm relationship beyond simply being allies of convienience, the two countries consistently published propaganda that portrayed the other country in a very positive way, they held a ''lot'' of genuine goodwill for each other as the war unfolded, and most of all, their encounter at the Elbe River was one of the most heartwarming things of World War 2.
* Boxing superstar Floyd Mayweather Jr. and popular Rapper Music/FiftyCent. They used to be seen everywhere together, but had a falling out in 2011, which resulted in a brief twitter feud.
** Fiddy and Music/TheGame were good friends until 2004 when the latter left Music/GUnit on bad terms after the former said that he was disloyal in saying that he didn't want to take part in the band's feuds with Music/{{Nas}}, Music/{{Jadakiss}}, and Music/FatJoe. The rappers threw disses at each other until 2006 when The Game offered the rapper to make amends, which did not happen. Another failed attempt at a reconciliation was when they collaborated in a tribute song to Music/MichaelJackson, shortly after the singer's death in 2009. The Game apologised, but 50 didn't accept it. They would eventually end their feud in 2016.
* Before the infamous East Coast Vs. West Coast Hip Hop war in the mid-90s, late rappers Music/TupacShakur and Music/TheNotoriousBIG were good friends and even appeared on some television interviews together. Tupac helped Biggie Smalls get into the business and even helped him with his lyrical style that he would later became famous for. All this changed after Tupac was shot five times and robbed while at Quad Recording Studios. He survived the shooting and blamed Biggie Smalls and Sean Puffy Combs (P Diddy), who were also there at the time of the shooting. Being an artist signed to Bad Boy Records, P Diddy's label, Biggie Smalls denied having anything to do with the shooting and defended his boss. Tupac would then start doing interviews dissing Biggie Smalls. Biggie Smalls mostly ignored the comments by Tupac and would change the subject whenever asked about it during an interview. Meanwhile, he released a hit rap song called, "Who Shot Ya?" Many fans immediately thought it was a Tupac diss and him admitting that he was responsible. Biggie Smalls, however, denied it and claimed it was just another rap song. Tupac responded by releasing "Hit Em Up", his famous TakeThat where he admitted to having sex with popular R&B artist Faith Evans, who was also Biggie Smalls' wife. Biggie Smalls was shocked when he heard this and soon became separated from her, though that was due to his high-profile affairs with Music/LilKim and Charli Baltimore than the diss. [[ToMakeALongStoryShort And it would only get worse.]]
* Creator/LuisBunuel and Creator/SalvadorDali had a very nasty falling out during the production of ''L'Age D'Or'', due to Buñuel's Communist sympathies and Dali's support for aristocrats and, later, Spanish dictator Generalissimo UsefulNotes/FranciscoFranco. They never resolved their issues either.
* Creator/StevenSpielberg and Creator/JohnLandis' friendship ended during the making of ''Film/TwilightZoneTheMovie'', after actor Vic Morrow and two child actors [[FatalMethodActing were killed in a helicopter stunt gone horribly wrong]] during Landis' segment.
* Creator/AkiraKurosawa and Creator/ToshiroMifune, who worked together in sixteen films, ended their friendship after the making of their movie ''Red Beard''. It's said that Kurosawa insisted that Mifune grow a natural beard and prohibited him from shaving it, preventing Mifune from taking any other acting jobs and nearly bankrupting him. Afterwards, their careers took different turns; Mifune continued enjoying success with a number of samurai and war-themed movies, and even became popular amongst American audiences in 1980. On the other hand, Kurosawa's output of films dwindled and garnered rather mixed responses. They finally reconciled in 1993, while attending the funeral of their mutual friend Ishiro Honda, the director of ''Godzilla''. Sadly, they never collaborated again, nor did they have the chance to fully reconstruct their friendship; Mifune died in 1997 and Kurosawa a year later.
* Creator/AlfredHitchcock and Music/BernardHerrmann were collaborators who spurred each other to make their best work in their collaborations, Hitchcock made his best films and Herrmann wrote his greatest scores. Then Hitchcock on ''Film/TornCurtain'' insisted that Herrmann change his score and follow his instructions. Herrmann pointed out that their agreement from Day 1 was that he would have total control over the music and that Hitchcock, who was not a trained musician, would not be PrimaDonnaDirector on him. They parted ways acrimoniously and never worked again though they apparently reconciled shortly before Herrmann's death. Everyone agrees that none of the music in Hitchcock's final films is a patch on Herrmann's work, while Herrmann did brilliant work right till the end (his final score was ''Film/TaxiDriver'').
* During UsefulNotes/TheHollywoodBlacklist many close friends were forced by Congress to testify and denounce anybody they knew as communists, which often meant their friends, and in some cases their husbands or wives. The climate of paranoia and denunciations ended many friendships and marriages. The most famous example is Creator/EliaKazan who after opposing the hearings initially, finally gave names to the Committee and wrote an Ad defending his actions. Kazan was an ex-Communist and widely admired as a leftist critic and everyone saw these actions as terrible betrayal, and it hurt Kazan's friendship with Creator/ArthurMiller and many others.
* Creator/OrsonWelles and producer John Houseman worked on all of Welles' Mercury productions and Houseman produced ''Film/CitizenKane''. Yet they had a falling out on the same project and both of them resorted to name calling each other in various interviews. Welles said later that Houseman, who was rumoured to be gay (though he married twice in his life and had two children with his second and last wife), was in love with him [[IncompatibleOrientation and was hurt when Welles could not return his affections]], while Houseman said that Welles was an egomaniac {{Workaholic}} who never properly acknowledged the pressures he put on Houseman and other people around him. Houseman later went on to become a prominent Hollywood producer on several notable films (the likes of Creator/VincenteMinnelli and Creator/NicholasRay), and Welles went on to make several films in the decades later but far more erratic and slapdash, lacking the stability Houseman gave him.
* One famous example was Creator/DeanMartin and Creator/JerryLewis. During TheFifties, the two of them were a highly successful double act and made several films together but then their friendship ended by the end of the decade and they never worked together again. On a moving note, at the end of TheEighties they publicly reconciled and appeared on Lewis' telethon together burrying their hatchet.
* Creator/BillMurray and Creator/HaroldRamis' friendship collapsed after making ''Film/GroundhogDay'' because of arguments of what direction the movie should take, [[CreatorBreakdown which was further complicated by Murray going through a divorce during filming]]. Happily, they reconciled shortly before Ramis' passing in 2014.
* Butch Hartman and Steve Marmel. The two were partners and the closest of friends during the pre-2008 episodes of ''WesternAnimation/TheFairlyOddParents'' and the first two seasons of ''WesternAnimation/DannyPhantom''. The two had a falling out over the third season of the latter (Marmel wanted the show to take a more serious route and supported Danny's relationship with [[DatingCatwoman Valerie Gray]] while Hartman was against it and insistent on Danny ending up with [[CreatorsPet Sam]] [[PerkyGoth Manson]]) which resulted in two ending their partnership and friendship.
* Music/FrankZappa and Music/CaptainBeefheart. These high school friends got along fine until the commercial failure of Beefheart's album ''Music/TroutMaskReplica (1969)'', which was produced by Zappa. Beefheart blamed Zappa and for about six years they had a fall-out. After Beefheart's career financially faltered, Zappa took him on tour in 1975-1976 and recorded the album ''Music/BongoFury'' with him, to help him out. Beefheart also performed mouth harmonica on Zappa's ''Music/OneSizeFitsAll'' and ''Music/ZootAllures'' on the pseudonym Bloodshot Rollin' Red. Unfortunately they had another fall-out soon after, because both were constantly trying to outdo each other in experimental weirdness. Only in the early 1990s, when Zappa was already ill with cancer, did the two friends finally make up.
** Zappa also had a fall-out with Wild Man Fischer, a local nutcase whose debut album, ''An Evening With Wild Man Fischer'' (1969) was produced by Zappa. One time Fischer threw a bottle at Zappa's infant daughter. He missed, but Zappa was furious and threw him out immediately. Fischer made matters worse by openly blaming Zappa for the commercially low sales of ''An Evening With Wild Man Fischer''. They never reconciled and Fischer died a poor man in 2011. ''An Evening With Wild Man Fischer'' was never reissued due to Zappa's widow Gail feeling that it didn't reflect well on her husband. It would be reissued in 2016, a year after Gail's death.
* Paleontologists Edward Cope and Othniel Marsh were once friends, but their search for new dinosaur species became a bitter rivalry. It began when Marsh bribed workers to help him acquire bones from Cope's dig site and escalated over the next two decades into a vicious race to out do each other. They hired spies to keep track of each other, hired away each others employees, and even destroyed each others' dig sites and fossil discoveries. This rivalry cost them both professionally and financially, but it did have the benefit of leading to the discovery of thousands of fossils and over a hundred new dinosaur species.
* Creator/TheCynicalBrit (aka [=TotalBiscuit=]) and the LetsPlay/{{Yogscast}} were once best friends in the VitriolicBestBuds sense, with many collaborations and publicly defending one another when push came to shove. The relationship took a nasty turn in Summer 2014, when TB was forced to call them out on the failure of their Kickstarter project and their disclosing sponsored content (since not doing so would have meant turning a blind eye when his channel advocates disclosure and is pro-consumer) and LetsPlay/LewisBrindley accused him and LetsPlay/NerdCubed (who is good friends with TB) of not disclosing sponsored content without any real evidence. Things were essentially left to be forgotten at that point on TB's end until March 2015, when LetsPlay/SimonLane called him a "crying pissbabby" [[YouMakeMeSic (sic)]] over a ''[[RuleOfCautiousEditingJudgement comic book]]'' no less, causing TB to publicly declare that he was cutting ties with the group.
** As time has passed, TB has since relented somewhat on his stance. In a Q&A, a fan asked whether TB would consider working with them again, to which he replied "not the big three", referring to Lewis, Simon, and CEO [[LetsPlay/{{Turpster}} Mark Turpin]]. He has, however, remained on very good terms with LetsPlay/{{Strippin}}, LetsPlay/{{Sips}}, and B-Lister [=PyrionFlax=], also playing games with LetsPlay/{{Sjin}}, LetsPlay/InTheLittleWood, LetsPlay/KimRichards, and LetsPlay/DuncanJones, indicating that he's at least on good enough terms with Martyn, Kim, and Duncan to work professionally. Lewis, for his part, has said that he would like to mend fences between both parties, but that remains unlikely.
* Music/CreedenceClearwaterRevival. Singer/guitarist/bandleader John Fogerty first became tight with bassist Stu Cook and drummer Doug Clifford in junior high, and formed a band called The Blue Velvets in 1959. John's older brother Tom would soon join the band. This tight bond among school friends and one family member was permanently destroyed in the early 1970s, as the band, now known as Creedence Clearwater Revival and on top of the rock pantheon, began to feud; mainly, it was Doug, Stu, and Tom getting fed up with John's dictatorial reign over all band decisions. To this day, the bad blood remains between John and Doug/Stu, even as all three founding members have recently turned 70 as of this writing. John and Tom weren't able to patch up their differences before the latter's death.
* Music/VanHalen. Up to now, founding members Eddie and Alex Van Halen remain in bad terms with former members Sammy Hagar and Michael Anthony. In fact, Eddie suggested in a recent interview that he isn't friends with vocalist David Lee Roth, suggesting that some of the issues that originally forced Diamond Dave out of the band in the mid-'80s have yet to be resolved a good three decades later.
* Wrestling/HulkHogan and Wrestling/RandySavage were once good friends in and out of the ring, but had fallen out in real life sometime in the mid-late '90s. The reasons aren't exactly clear, and as recently as the 21st century, Savage was still openly disdainful towards Hulk, recording the Hogan diss song "Be a Man" in his ill-fated rap album. Hogan, however, made up with Savage shortly before his death in 2011, and posthumously inducted the Macho Man into the WWE Hall of Fame in 2015.
* NBA superstars Earvin "Magic" Johnson and Isiah Thomas were good friends and rivals for most of their NBA career, but became estranged for over two decades when the latter spread (false) rumors of Magic's homosexuality following his HIV diagnosis in 1991. This rift lasted until 2013, when Johnson confirmed in a tweet that he had patched things up with Thomas.
* {{Indycar}}'s Will Power and Simon Pagenaud were the best of friends, to the point of even vacationing together, until Power (intentionally or accidentally depending on who you ask) knocked Pagenaud into the tires at the 2014 Grand Prix of Long Beach when Pagenaud was running in the top five, at which point their friendship ended. They patched things up in 2015, after Pagenaud joined Penske Racing, which happened to be the same team that Power raced in, and are now back to spending time together on tour and on off time.
* Creator/FrancoisTruffaut and Creator/JeanLucGodard never spoke to each other again after Godard publicly slammed ''Film/DayForNight'' and Truffaut responded with a [[TheReasonYouSuckSpeech lengthy letter]] criticizing Godard's flirtations with Maoism. Godard tried to reconcile in TheEighties but Truffaut rebuffed him, and shortly after the latter died of brain tumor. Since Truffaut's death, Godard has written introductions and offered tributes to his former friend and has expressed regret at what happened.
* [[UsefulNotes/HillaryRodhamClinton Hillary Clinton]] and Creator/DonaldTrump were chummy when she was one of New York's U.S. Senators and he was a registered Democrat. The Clintons were guests at Donald's wedding in 2005, and Bill was also a golfing buddy of Donald. Donald made frequent donations to Hillary's campaigns, hosted fundraisers for her, and endorsed her for president in 2008. Not the case anymore when they ran against each other for president in 2016, with Donald (now a Republican) ran what many pundits called the most vulgar campaign in memory, calling her "crooked", "the devil", and "a nasty woman". Prior to the second presidential debate, Donald held a press conference with several women who had accused Bill of sexual harassment. Trump eventually won the election[[labelnote:*]] (but lost the popular vote by nearly 3,000,000)[[/labelnote]] against his former friend.
** Donald Trump actually used to be chummy with Rosie O'Donnell, enough so to invite her to his 1993 wedding to Marla Maples, prior to the years-long thermonuclear feud between the two.
* [[UsefulNotes/HeresiesAndHeretics Galileo Galilei]] and [[UsefulNotes/ThePope Pope Urban VIII]]. Galileo held scientific views that were in opposition to the church, but his good friend Pope Urban enjoyed a good debate and encouraged Galileo to publish his views. Unfortunately, Galileo wrote his arguments in the form of a dialogue, and the character representing the pope was named "Simplicio" ("The Simpleton"), and spoke in a manner than suggested he was foolish and stubborn. Their friendship over, the pope demanded that Galileo be brought to trial for spreading heresy.
* Creator/DannyBoyle and Creator/EwanMcGregor were good friends with the latter starring in the former's first three films before their friendship deterioriated when they had a feud after [=McGregor=] was not happy with the treatment that Boyle gave to him after being dropped out of ''Film/TheBeach''. They would not be in speaking terms until 2013 when they patched things up after Boyle admitted to unfairly treating him and [=McGregor=] regretted the feud in a 2016 interview.
* Creator/GeorgeLucas and Gary Kurtz were good friends before disagreements over the direction that the ''Franchise/StarWars'' franchise had taken after ''Film/TheEmpireStrikesBack'' led their friendship and partnership to end. Kurtz didn't like the franchise becoming MerchandiseDriven as he suspected that Lucas was trying to play up the merchandising angle of the movie more with characters like the Ewoks (ironically, the toys for the latter creatures did rather poorly in merchandise sales), putting more emphasis on special effects than story and was in favour of Han Solo being KilledOffForReal in ''Film/ReturnOfTheJedi'' in addition to the film being DarkerAndEdgier than ''Empire'', but Lucas wanted Han to survive and decided to have the Death Star back for the film in addition to being LighterAndSofter than ''Empire'', which Kurtz strongly opposed (as he felt that it would be rehashing the Death Star conflict). After that, he quit just a month before production for ''Empire'' (which was a TroubledProduction) ended and was replaced by Howard Kazanjian.
* Phil Anselmo and Vinnie Paul Abbott from Music/{{Pantera}}. Tensions between the two members of the GrooveMetal band began in 1995 when Anselmo became addicted to heroin, which put a strain on their friendship, leading to ''The Great Southern Overkill'' to be [[CreatorBreakdown recorded in separate locations]]. Followed by Anselmo's near-death experience from a heroin overdose in 1996, this tension went ongoing for seven years until Vinnie and his brother Dimebag Darrell disbanded Pantera in 2003 after ultimately deciding that Anselmo would not return to the band. [[FromBadToWorse This gets much worse]] as a year later Anselmo said to ''Metal Hammer'' that "Dimebag deserves to be beaten severely", which angered Vinnie Paul and months after, Dimebag was killed by a deranged fan during a Damageplan performance. In the aftermath, Anselmo tried to contact Vinnie but Vinnie refused as he didn't want to speak to him and then Dimebag's girlfriend Rita Haney told him she would rather "blow Anselmo's head off" if he ever attended his funeral. Two years later, in an interview with Crave Online, Vinnie Paul said that he would never reconcile with Anselmo though Anselmo and Haney have since patched up their differences.
** Vinnie has also severed ties with fellow member Rex Brown. In fact, fans have called him selfish for his actions towards Phil and Rex because apparently wanting your fallen brother to be paid tribute to and have the good times you and your band-mates/friends shared together held in remembrance is selfish.
* Gary Barlow, Jason Orange and Music/RobbieWilliams were good friends by the time they were members in British BoyBand Music/{{Take That|Band}} but by 1994, Williams suffered a near-fatal heroin overdose the night before the MTV Europe Music Awards, which the band was going to perform. Then a year later, just months after Take That had their biggest hit at the time "Back for Good" (which remains their [[OneHitWonder only American US Top 40 hit]]), Williams was photographed partying with Music/{{Oasis}} at Glastonbury, which put a strain in him and the other two. Due to his party lifestyle and erratic behaviour, he was given the ultimatum: Follow the band's responsibilities and quit partying or quit, which he chose the latter. After Williams' departure, the band did an American tour and then decided to disband in mid 1996. A year after the disbandment, Williams became the BreakupBreakout of the band and becoming more successful than the band themselves. This went worse, when in a 1999 interview, Williams openly criticised Barlow's solo work, which unfortunately resulted in Barlow taking a break from music until 2005, when the band decided to reform. Williams was invited to take part in the reunion but declined though he apologised to both Barlow and Orange, as they then patched up their differences, leading to him rejoining the band in 2010 though leaving for a second time in 2013, but this time on amicable terms as Williams decided to focus on his solo career and his family life and Barlow has said that Williams is welcome to rejoin.
* Music/DemiLovato and Music/SelenaGomez were already best friends, having starting their careers in ''Series/BarneyAndFriends'' but their friendship almost ended with a falling out in 2009 though they later reconciled. In 2015, they fell out partly due to Gomez had become good friends with Music/TaylorSwift (to the point that Lovato wasn't favourable towards Swift's "Bad Blood" in early 2016). However, they patched up their differences in late 2016 as Demi supported Selena when the latter went to rehab in order to treat her lupus condition.
* Music/LadyGaga and Music/{{Madonna}} were good friends as the former was set to be the latter's SpiritualSuccessor until the latter criticised the former's "Born This Way" and calling it "reductive", feeling that it ripped off her song "Express Yourself". Gaga was not very happy at all, given that Madonna was a major influence in her career and said that the comparisons between the two songs were completely unintentional.
* Music/KatyPerry and Music/TaylorSwift were friends, had a falling out, and Swift recorded "Bad Blood" which was apparently about Perry stealing Swift's backup dancers, though Swift hasn't confirmed if the song is about her. Shortly after "Bad Blood" became available online, Perry tweeted, "Watch out for the [[Film/MeanGirls Regina George]] in sheep's clothing..." Thankfully, [[http://www.digitalspy.com/showbiz/news/a856637/taylor-swift-katy-perry-end-feud-olive-branch/ the beef was finally squashed in 2018]].
* Creator/ElizabethTaylor and Creator/DebbieReynolds were good friends during the breakthrough period of their careers, and after Taylor's husband Michael Todd died in a plane accident, Reynolds and her husband Creator/EddieFisher comforted her until Fisher [[YourCheatingHeart began having an affair with Taylor]], which devastated Reynolds and led their friendship to become estranged, and the day after Reynolds' divorce was finalized, Fisher married Taylor, which lasted for five years. Two years after divorcing Fisher, Taylor apologised to Reynolds and Reynolds forgave her, resulting in the two reconciling and resuming their friendship. They remained good friends until Taylor's death in 2011.
* Talaat Pasha and Krikor Zohrab, an Armenian Member of the Ottoman Chamber of Deputies were friends before the Armenian Genocide. Once the genocide started, they played a card game as they usually did, and discussed the deportations and massacres. Krikor Zohrab tried to convince Talaat to put an end to the atrocities. When the game ended, Talaat kissed Krikor Zohrab on the cheeks and bade him goodbye. That was the last time they ever saw each other, as Talaat had Zohrab arrested, and then executed.
* Creator/GwynethPaltrow and Creator/WinonaRyder were inseparable best friends in the 1990s, then were no longer on speaking terms for reasons unknown. A popular rumor is that Paltrow stole her Oscar-winning role in ''Film/ShakespeareInLove'' from Ryder, though Paltrow vehemently denies this. Paltrow hasn't spoken about the friendship but did give an interview vaguely referring to "a 'frenemy' who, as it turned out, was pretty hellbent on taking me down".
* Kenan Thompson and Kel Mitchell were a ubiquitous duo in the 1990s, starring together in ''Series/AllThat'', ''Series/KenanAndKel'' and ''Film/GoodBurger'', but by the 2010s [[http://www.tmz.com/2012/11/23/kel-mitchell-kenan-thompson-feud-fallout/ Kel claimed]] that Kenan was actively avoiding him. In 2015 [[http://www.usmagazine.com/entertainment/news/kenan-and-kel-reunite-for-amazing-good-burger-sketch-with-fallon-2015249 Jimmy Fallon]] took it upon himself to reunite them.
* Creator/JayZ and Creator/KanyeWest were good friends since the late Nineties, especially the latter making his big break on the former's ''The Blueprint''. The duo would record the album ''Watch the Throne'' in 2011 but their friendship began to burst in 2016 when West dissed his friend for not visiting him after his wife Creator/KimKardashian had her jewelry stolen in Paris and a year later, Jay Z dissed West on his album ''4:44'', which led to West severing ties with Tidal as co-owner and shareholder of the streaming service.
* Creator/BillHicks and Creator/DenisLeary were friends until Hicks heard Leary's album ''No Cure for Cancer'' and felt that it plagiarised his own routine. Their friendship abruptly ended as a result.
* Music/SouljaBoy and Arab. They used to be good friends, while making rap songs together. They had a falling out due to a gun incident and [[https://www.youtube.com/watch?v=mBNK7ZN4VGM Arab ended up getting kicked out of SODMG in 2011]].
* This is the case with [[Music/TheFaceless Michael Keene]] and most of the former personnel, but ''especially'' with Justin [=McKinney=] and Ken Sorceron. Both were good friends of his before joining, and Ken in particular was one of his oldest industry friends and main defenders. Several years of being in a band with Keene destroyed every last ounce of their good will towards him, as his drug issues, unpleasant personality, and total refusal to take responsibility for his actions or even attempt to adequately address his drug problems cost them an incredible amount of money and career opportunities, and after Keene rewarded them for their efforts by badmouthing them to others and telling them that they were "the weakest lineup" and that he didn't even need them to their faces after a nightmare of a European tour, they decided that they had simply had enough.
* Judging by comments that Austin Archey made on Twitter after Tom Barber joined Chelsea Grin, Lorna Shore is furious with Tom for using a band that he helped build up with the rest of them to the point where it was finally going somewhere as a vehicle for personal gain and little else, and judging by Archey's post, Tom had been acting like he was the star of the show for some time before that.