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[[quoteright:349:[[VideoGame/MarvelVsCapcom3 http://static.tvtropes.org/pmwiki/pub/images/cap-and-galactus_2564.png]]]]
[[caption-width-right:349:Not even ''[[MadeOfIndestructium your]]'' [[LuckilyMyShieldWillProtectMe shield]] can protect you from the FrickinLaserBeams of ComicBook/{{Galactus}}, [[ComicBook/CaptainAmerica Cap]].]]

A particular attack in an enemy's arsenal which is significantly more dangerous than most of its attacks.

If you have a party, it will almost always target all party members, and it often takes off the majority of your hit points, if not [[OneHitKill worse]]. It's a staple for ThatOneBoss to have one of these, possibly more.

This attack showing up even once is always bad news; if the AIRoulette gives you [[LuckBasedMission two in a row]], expect to see the GameOver screen. Whether or not you can beat ThatOneBoss that uses this attack usually depends entirely on whether or not you can [[LuckBasedMission avoid/endure/recover]] from it.

SkillGateCharacters may also derive their harmful-to-newbies nature from having one of these, and thus falter when the opponent learns to counter it. If these are available to players without suffering RedemptionDemotion, they usually become {{Game Breaker}}s.

----
!!Examples:

[[index]]
* ''ThatOneAttack/FinalFantasy''
* ''ThatOneAttack/{{Pokemon}}''
* ''ThatOneAttack/{{Touhou}}''
[[/index]]

[[foldercontrol]]

[[folder:Shin Megami Tensei]]
* As a general rule, pretty much any high tier Almighty (can't be resisted by anything) attack such as Megidolaon can quickly become a nightmare.
* Butterfly Storm from ''VideoGame/{{Persona}}''[='=]s [[spoiler:Pandora]]. Large damage and status ailments.
* Terror Fortune from ''VideoGame/{{Persona 2}}''[='=]s [[spoiler:Metal Jun]]. See above.
** Bloody Divorce from [[spoiler:Metal Eikichi]]: Huge Water Damage, and high chance of instant death.
** Hula of Misfortune: Watch a hula-dance, lose half of your total money. You don't get it back.
** Aimed Shot: Chance of instant death. One boss battle has his four elite mooks spam this on end.
** Kudan's attack "Prophecy" kills the monster in question, but it will ''revert all of your active Personae to Rank 1 and remove any mutations they received''. And it doesn't wear off.
** Old Maid. Get ready to waste an entire round or eat painful death from your own characters.
** In ''Innocent Sin'': Mephistophiles. Random statuses to your entire party. And it's the opening move of a ChestMonster.
* Night Queen from ''VideoGame/{{Persona 3}}''[='=]s [[spoiler:Nyx Avatar]]. Sizeable damage, devastating status ailments. If it happens to Charm your healer, get ready to fight the last form from the beginning.
** On the other hand, if it happens to charm someone else, don't be surprised if the last vestiges of thine HP are wiped by any of many fun weapons.
** On the same boss: "Moonless Gown." Not an attack, per se, but brutally unfair nonetheless. Not only does it make it entirely immune to damage (even almighty damage) for a couple turns, it also reflects that same damage back to you. The final boss of ''VideoGame/{{Persona 3}}'' is a monster.
** Not to mention that, in a truly irritating display of ArtificialStupidity, your allies will blindly attack the Moonless Gown unless you stop them, even though both [[MissionControl Fuuka]] and common sense say that they shouldn't. This can be especially brutal if you've had to revive any of your allies, in which case they take their turn after Moonless Gown is cast...but before you can change their tactics.
*** The obvious answer to the above is to use your teammates that are immune to the same elemental spells that they cast, right? Wait, no, the boss just uses the appropriate Break skill to remove their immunity. And you thought you were so clever.
*** What makes this ''even worse'' is that your party typically holds back when reflects go up. Nobody will dare risk breaking a Tetrakarn (physical reflect barrier that lasts for ''one'' hit) even if it would barely damage them in the process. And yet they will practically throw themselves at Moonless Gown. ''Even if they should already know what it does.''
** The Mythical Gigas' Deathbound hits everyone for a huge amount of Strike damage. It's about 300 damage if it doesn't critical (you'll probably have 480 HP, tops, by the time you reach him), and if it criticals, that number can easily exceed '''1000''', and no amount of LevelGrinding will allow you to survive when that happens.
** [[spoiler: Elizabeth]]'s infamous 9999 damage Megidolaon ([[ThereIsNoKillLikeOverkill the HP cap is 999, by the way.]]) She uses it once per move cycle, meaning you better have a way to counter it. And even if you do, if you break the rules of the fight, she'll immediately use it twice in a row to make sure you stay dead. The attack is so infamous that it returns in Persona4Arena as her OneHitKill attack.

* Dark Embrace from ''VideoGame/{{Persona 3}} FES''[='=]s [[spoiler:Erebus]]. When it uses this attack, unless you manage to deal enough damage in time, it'll deal a good amount of damage to you. Survivable at first, but it gets stronger throughout the battle, so when you see it charge up Dark Embrace, throw everything you have at it.
* [[spoiler:Izanami-no-Okami]] from ''VideoGame/{{Persona 4}}'' has World's End, which is game-ending if you can't figure out how to avoid it. Huge damage to your entire party, chance of status ailments to everyone. She also follows it up by immediately using Summons to Yomi, which kills any character with status ailments. [[spoiler:But it's only That One Attack to players that don't recognize when the game is telling them to defend: she spends her two turns charging up and telegraphing the attack the round before she uses World's End, and it does nothing whatsoever to characters who are guarding.]]
** Rampage, used by the Contrarian King. Hits your whole party up to 3 times for huge damage and will one shot your entire party if you fight him as soon as you can.
** Kunino-Sagiri's Control, which brainwashes one of your characters. They do the same things as they would if they were Charmed, but 1: it's unavoidable, and 2: it's incurable; you have to wait it out. After Kunino TurnsRed, he'll take control of ''three'' of them. Just pray they don't use Diarahan.
** Stagnant Air increases everyone's susceptibility to ailments by at least 50%, which then makes the combo of Evil Smile (whole party, causes Fear) and Ghastly Wail (anyone with Fear dies) a TotalPartyKill unless you're really lucky. There are two [[HopeSpot Hope Spots]] to it, though; it can be used against enemies, and it wears off after a while.
** Shadow [[spoiler:Yukiko]]'s [[KillItWithFire Burn To Ashes]] for beginners. At this point, you only have three party members; one of which has a fire weakness. You can pick up a Slime that has Red Wall, which can seal said party member's weakness for 3 turns... but Slime itself is weak to fire, and the only healing spell you're likely to have at this point is Dia or Media. And since this is [[NintendoHard an Atlus game]], the AI will exploit any chance you give it [[WeCannotGoOnWithoutYou to murder you]].
*** On the same boss, the [[spoiler:Charming Prince]] has an attack called Terror Voice, inflicting Fear upon you. It's not so bad on its own. The real kicker is when [[spoiler:Shadow Yukiko]] follows up with Shivering Rondo, which does a HUGE amount of damage to anyone inflicted with said ailment.
** Everything used by [[spoiler:Mitsuo The Hero]]. His regular attack can deal out ''triple-digit damage'', is unblockable, and is enough to kill anyone in two shots, which is a serious problem considering [[spoiler:Mitsuo]] gets 2 turns. Then there's Bomb, which deals massive damage and can cause Exhaustion, which drains SP every turn. Lastly, he has Gigadyne, which is as strong as his regular attack and it hits the whole party, but Gigadyne can only be used if [[spoiler:Mitsuo The Hero]] is completely recreated. Note that should this boss reform completely, both the regular attack and Bomb will increase in power.
** Shadow [[spoiler:Kanji]]'s Roar of Wrath, which gives female characters the Rage status. While this could work in your favor (when enraged, people will attack enemies with boosted strength), the only two females in the party at the time are Chie and Yukiko. And Yukiko is the designated [[TheMedic healer]] for the party. He also likes to follow this up with Tetrakarn, making those powerful attacks go right back at the girls. Have fun watching them get [[OneHitKill instantly killed]] for attacking [[spoiler:Kanji]]! This is also made potentially worse if you haven't killed off one of the flunkies that are HEALED by physical attacks.
* Megidoladyne from ''VideoGame/DevilSurvivor'''s [[spoiler:Lucifer]]. Deals enormous damage to everyone in every friendly party, and gets stronger the more times he uses it. 50% more powerful, to be exact. Once he TurnsRed, he will use it every turn. [[spoiler:Lucifer]] will use it upon [[spoiler:changing into his second form]] and every turn afterward. And inevitably again upon [[spoiler:turning into his third form]]. Since Megidoladyne becomes more powerful every time he uses it, it becomes an instant kill on the entire map after four-five uses. If the party is adequately overleveled. Which means that you have to beat [[spoiler:Lucifer's second and third form]] without letting him have more than two turns. Welcome to hell.
** For reasons mentioned above, the fight with [[spoiler:Lucifer]] can become literally impossible, as he will be doing more damage in one attack than the maximum HP any member of your party is allowed to have, regardless of level, and [[spoiler:Lucifer]] is not capped on how often or how fast he can cast it. [[spoiler:Lucifer]] is easily capable of casting Megidoladyne extremely rapidly in his third form at random, and even at maximum level with the best demons and skills possible equipped, making it so that no matter what you do to prepare, the fight with [[spoiler:Lucifer]] has a real chance of being totally impossible to win after you've already beaten his first two forms. Welcome to hell, indeed.
* ''DigitalDevilSaga'''s BonusBoss, [[spoiler:Hito-Shura/the Demi-Fiend]], gives us "Gaea Rage." Deals around 7,000 points of damage to every character when your maximum HP is 999. Not to mention the only defense against it is very vague and requires luck to work. You'll have nightmares about it. Additionally, he'll immediately throw it out at the start of battle if you have any elemental immunities, killing you before the command menu even shows up.
** Being possibly the hardest boss in video game history, all of his attacks are pretty devastating. Javelin Rain hits everyone for decent damage and can inflict Stun while Xeros-Beat substitutes the (more devastating) Mute for Stun. Even his basic physical attacks are cringe-worthy, as not only do they hurt badly, but he has an ungodly high chance of getting a critical hit and getting an extra turn.
** Adding insult to injury is having played ''Nocturne'' and realizing that Gaea Rage isn't even a particularly good attack. Apparently, he deems you unworthy of wasting Spiral Viper or Freikugel... or of bringing [[VideoGame/DevilMayCry Dante]] as backup. He's generally not wrong about that.
** There's also Vanity, the DDS equivalent of Bad Breath (see below).
** Zotzilaha Bane, used by Camazotz. It turns one party member into a bat, giving them abysmal stats and a large weakness to Force. Three guesses what all of his elemental attacks are.
* ''VideoGame/ShinMegamiTenseiIIINocturne''
** Matador's Red Capote maximizes his Hit/Evasion rates, making it nigh impossible to land an attack if you aren't prepared to counter it somehow. Missing an attack is SeriousBusiness in this game because the attacker's party loses ''two'' turns instead of one for a missed attack.
*** Also, Andalucia, which hits the entire party several times. It doesn't do that much damage on its own, but is usually used after Focus, making the first hits very strong, or even worse ''Taunt'', which puts a huge dent in your defense.
** Ahriman's Apocalypse deals incredibly high unblockable damage. Pray that he doesn't use Megidolaon on the same turn.
** If the TrueFinalBoss ever decided to use High King or Root of Evil twice in a row, you were pretty much dead. Keeping your HP maxed every round was necessary to survive it, despite its low probability.
** Dragon's Eye, turning one press turn into four halves.
*** Beast Eye, turning one into two halves. However, these halves can be turned into ''two more halves each''. WHY?!?
** Bael's Bane, which turns your ally into a fly. Can be blocked, at the cost of being weak to instant kill magic the boss uses (bar [[CrazyPrepared Crazy Preparation]] of course).
** Death Flies: either you're immune to dark-type death or you... well, die. Otherwise you take heavy almighty damage.
** Fire of Sinai: the random number generator god seems to enjoy having multiple hits of almighty on your main character.
** Holy Melody if you're not careful. Yay, let's have the boss ''fully heal himself'' shall we?
*** Same goes for Evil Melody. Main character a bit lower on HP than other party members? HE DIES!
** ''Anything'' used by [[VideoGame/DevilMayCry Dante]]. Stinger hits one character for Almighty damage, and ''instantly kills anything'' on a Critical. Provoke is an enhanced version of Taunt, which drastically increases your attack but lowers your defense; Provoke does this and, instead of spending a huge amount of MP, it actually heals Dante's MP. He also has an attack called Showtime, which deals a gigantic amount of Almighty damage to your party, and Bullet-Time, which hits your party for pretty good damage and causes Panic.
*** There's also ''Rebellion'', which has a crit chance so absurdly high that you might as well just assume it will always score a CriticalHit. And ''E & I'' which, although not as strong as other attacks, hits 4 times, so if he scores a CriticalHit with this, you're probably dead.
** White Rider's ''God's Arrow'': 100% OneHitKill if you don't null expel. It doesn't help that the same boss also has Prominence, the strongest fire spell in the game, so if you want to avoid one you cannot avoid the other.
** Red Rider's Terrorblade. It does huge damage and can randomly cause the Panic status. One of three things will happen when someone has this status (aside from nothing): They lose a turn, they throw away some money, or if it's a demon, they might ''run away''. Granted, you can call them back, but that's only if the Demi-Fiend didn't get hit by it as well.
** Sol Niger, used by Aciel, is an HPToOne attack that hits the whole party. Bosses get two actions in one turn, and Aciel will ''invariably'' use that second action to attack one of your characters. If he hits the Demi-Fiend? [[WeCannotGoOnWithoutYou You had better be used to that Game Over video.]]
** Surt's ''Ragnarok''. Good luck surviving that if you don't resist Fire. It doesn't help that later when he turns into a DegradedBoss, Surt appears in groups of at least 3, so there's a chance they'll use it more than once on the same target. You'd be surprised by the amount of times they do this to the Demi-Fiend....
* ''VideoGame/ShinMegamiTenseiStrangeJourney'':
** First off, anything that causes fear. Your demons may not do anything -- or even ''retreat'' -- and it can last multiple turns.
** Asura Roga, used by (who else?) Asura [[spoiler:(and the final boss, if you're really unlucky)]]. This causes Rage, which cannot be cured with anything but Amrita or Salvation (and you don't ''have'' the latter at this point). Rage is similar to Charm, with the minor difference that the victim can attack anything, Asura included -- but the odds are much higher they'll attack the party.
** Wave of Death, which deals ''ungodly'' damage. If Ouroboros uses it twice in a row, you lose.
** Ouroboros also has another godawful attack: Disaster Cycle, which inflicts random status effects on everyone in the party. One unlucky turn where she hits the player character with Petrify or Bomb and [[WeCannotGoOnWithoutYou you lose instantly]]. And in her second form, she spams it.
** Any Almighty skill. You have no way to block them. (Neither do your enemies, but guess who'll face them more often?) Bonus points to Hostile Terror, this game's answer to Bad Breath (see below).
** Mitra has Light of Order, an instant death attack directed towards a random demon. Although it cannot target the protagonist, this attack is annoying because you have to waste turns reviving and resummoning whoever gets hit.
** And finally healing ones: Tiamat, [[spoiler:Captain Jack, and Ryan]] would be WAY easier if they didn't have Pure Blue to [[TheComputerIsACheatingBastard fully heal them and cancel all debuffs]]. Only Tiamat gives a way to avoid it (do not reduce any of her stats to -4). Or [[spoiler:Commander Gore]]'s Self-Denial, which heals and boosts attack, or that moment when he hits 0 hp ''and then regenerates 7500 spontaneously'', giving a higher total HP than anything else in the game! This is a NintendoHard game, [[HarderThanHard if not more so]].
** [[spoiler:Gore]] has ''Adaptation''. This is an attack he will only use on the main character, and the only way to survive it is to have full health, be on defense, and have something equipped to resist physical attacks. Even then, there's no guarantee this move won't flat-out kill you.
** And, depending of the amount of money you happen to have at hand, you will want to kill yourself if a an irredeemably stupid enemy hits you with Macca Beam, or God forbid, Wastrel Beam. You lose, not a fixed amount, but a percentage of your total. You can lose hundreds of thousands of Macca to Kangiten's Wastrel Beam.
** Anything that causes the Bomb status. If a Bombed character gets hit with even the weakest attack, they die and deal their HP in damage to the party. Gods help you [[WeCannotGoOnWithoutYou if the unlucky target happens to be the main character]].
** [[spoiler:Mother]]'s Kiss, used by the FinalBoss on the Law and Neutral paths. It hits '''''6 to 8 times''''' for physical damage and can deal four-digit damage even with your defense capped. There is one way to negate it, but by using it, you make yourself vulnerable to the boss's OneHitKill moves. And she uses it ''a lot''.
*** [[spoiler:''MA'']]. Like Mitra's ''Light of Order'', it is a guaranteed, '''unblockable''' instant kill of one character. This time, however, it CAN target the protagonist, and more often than not DOES. [[{{Ragequit}} I hope you know how to repair a DS.]]
** ''Requiem'', used by the final boss of the Chaos path. Remember how we were talking about Almighty attacks earlier? This is an Almighty ''instant-kill attack''. And yes, the boss will use it on the protagonist. It isn't guaranteed to hit, but if it does, there is ''nothing'' that can block it. Basically, it's [[spoiler:Pillar Zelenin's]] version of [[spoiler:''MA'']]. Just in case you thought the Chaos final boss would be easier than [[spoiler:Mem Aleph]].
* In ''VideoGame/ShinMegamiTenseiIV''...
** ''Fallen Grace'', used by [[spoiler:Michael of the four Heralds, who can be battled as DLC]]. This move does a GUARANTEED 666 damage, and due to the fact that he can also bestow Smirk upon himself, he can easily use this twice in a row. Oh, hit the main character again? You're in trouble. Also, [[spoiler: you fight him on the heels of Gabriel, with her status-spamming, Brand-inflicting ''Lamentation'', itself a ThatOneAttack if you don't know how to deal with it]]. [[spoiler:Raphael]]'s ''Stigmata Strike'' can also cause Brand, and it is GUARANTEED TO. At least you can use it...
** ''Ancient Curse'', usable by Kenji and [[spoiler:Yaso Magatsuhi]]. Yay, let's have to deal with all five status ailments AT ONCE for the WHOLE PARTY! At least some demons, including the latter, can use a version of the same, ''Shivering Taboo'', when fused. [[spoiler:Gabriel]] has her own version, ''Lamentation'', which adds Brand to the fun.
** ''Labrys Strike'', which does massive physical damage, and hits a few times. Oh, and it's usable by the first major boss, [[spoiler:Minotaur]]. If he uses it multiple times in one turn, you're in trouble.
** ''Damnation'' and ''Stigmatic Gleam'' from the Ancient of Days' DLC fight. Massive Almighty damage with 100% chance of Poison for the first, worse damage and ''Brand'' for the second.
** ''Macca Beam'' and ''Wastrel Beam'' return. Again, the first shaves off 20% of your total money. The second vaporizes ''half your money'' into oblivion.
** [[spoiler:Merkabah]]'s ''Hexagram''. A guaranteed Almighty instant kill. At least the loss of the protagonist doesn't end the game...
** ''Blight'': a favorite of Macabres and Oses, as well as [[BonusBoss David]], which targets your entire party for 100% accurate weak Phys damage. For reference, by that point your herd-hitting physical will be the inaccurate ''Critical Wave'', or ''Heat Wave'' if you're a diligent grinder. Unlike ''Heat Wave'' however, ''Blight'' also has a built-in poison chance clocking in at roughly fifty percent. Add that to the fact it has the chance to critical, giving them another press turn and a probable Smirk, and a single ''Blight'' can be the harbinger of doom for an entire team. ''Blight'' is one of the most atrocious attacks even late into the game, as it will be a long time until you can get spells that will allow you to lift Poison from the entire party at once.
[[/folder]]

[[folder:RPG]]
* Many examples in ''VideoGame/TheLordOfTheRingsTheThirdAge''.
** The Balrog has two, but they're really two shades of the same attack: Pillar of Wrath and Scorching Inferno. Both of them hit every member of your party, and both will drain almost all of the AP your characters have.
** Stomp from the Mūmakil. Hits everybody, and stuns them. Stand Fast makes it mostly worthless (it's still kinda painful), but if it gets it off before Berethor gets a turn... Well, you're [[TotalPartyKill screwed.]]
** The Final Boss, Sauron, has 2. Darkest Fear immobilizes one of your guys and deals damage over time, and Berethor's Immune to Fear Passive ability and Shield of Courage Leadership do not work to stop it, unlike regular Fear. Silence of Light also immobilizes your entire party's Spirit skills. It's a huge pain, since most of your best abilities are Spirit, and you need them to last long enough to kill him.
* Cruel Ruin and Djinn Storm from ''VideoGame/GoldenSun: The Lost Age'''s Doom Dragon.
** Literally ''every attack'' done by [[BonusBoss Dullahan]] counts as ThatOneAttack. Dark Dawn might have been disappointingly easy, but Dullahan somehow got even harder.
** Djinn Blast is a lesser cousin, but no less aggravating. Used by the Chaos Chimera in ''Dark Dawn'' and by Karthas in ''The Lost Age''.
** The Ancient Devil's Demon Sign [[BrainwashedAndCrazy takes over one of your characters]]. And they can use your djinn for summons, though they won't always do this.
** The fangame ''VideoGame/TouhouLabyrinth'' borrowed Djinn Storm, and it is every bit as annoying (Empties all party members' SP, including the SP of those in reserve).
** The Chaos Chimera has Retribution, a reasonably strong attack which hits the entire party. It also has a chance of causing instant death. Oh, and the Chaos Chimera always attacks three times in a row. Have fun.
** Star Magician used Mystic Call! Star Magician summoned Refresh Ball! Star Magician used Mystic Call! Star Magicican summoned Gaurdian Ball! Player's anger was increased by 259 points! [[labelnote:context]]Refresh Balls heal the Star Magician to the tune of 1000 HP per cast, while Guardian Balls vastly reduce the damage he takes.[[/labelnote]]
*** Ghoul Ball used Consume Djinn! Sveta's Fleet was eaten! Player's anger increased by 100! [[labelnote:context]]Ghoul Balls, summoned by the aforementioned Star Magician, can lock one Djinn into Recovery mode (cannot unleash, convey stat or class bonuses, or use in summons) per invocation until the offending Ghoul Ball is destroyed.[[/labelnote]]
* [[OneHitKill Cunning Blow]] in ''MagiNation''.
* In ''ValkyrieProfile'', any enemy with the Great Magic spells will have it as its ThatOneAttack, such as Akhetamen's Seraphic Law, Wraith's Gravity Blessing, Barbarossa's Calamity Blast, etc.
** Almost every attack [[ThatOneBoss Bloodbane]] has qualifies. He will often follow up a damaging claw swipe ''("I'll crush you!")'' with Feel My Flame, which deals huge damage to the entire party. Occasionally he will follow this with a magic spell like Sacred Javelin, most likely killing one of your Einherjar. And when taken down to below half HP, he will start spamming the Great Magic Gravity Blessing, which can cause a TotalPartyKill.
** Fenrir in the [[GoldenEnding A Ending]] has Frost Bait, which it uses when [[TurnsRed at low health]] and deals huge damage with a chance of freezing anyone hit. A special item from the mid-game can stop it from freezing your party members, but it won't do much against the damage. The Fenrir clone in the [[BonusDungeon Seraphic Gate]], [[NamesToRunAwayFromReallyFast Carnage Beast]], can use Frost Bait both at full health and low health. Encountering two Carnage Beasts and having them do two Frost Baits in a row is likely to result a TotalPartyKill unless you have [[GameBreaker the Guts/Auto-Item/Union Plume combo]].
** The TrueFinalBoss, [[spoiler:Loki]], has two: Extension Force, which deals a single devastating blow to each party member; and Dragon Orb, a unique Great Magic that is just as painful as the rest.
** The [[KillerRabbit Hamsters]] in the Seraphic Gate have Furry One, which tramples the party under a wave of hamsters for ludicrous damage.
* In ''DigimonWorld3'', even some normal attacks are that one attack. Mamemon's normal attack can freeze your Digimon, with a very high chance of blocking it from doing anything. Even better: it blocks you from healing your Digimon. Depending on your luck, you'll just mash X until your Digimon die.
** Hi Andromon has Atomic Ray, which has a solid chance of causing death regardless of your defenses.
** Pharaohmon, the very first boss, has Necro Mist, a move that not only deals high damage, it also has a almost sure chance to poison your Digimon. Wouldn't be so bad if Poison didn't eat 25% of your HP every time you get a turn.
** Vademon has an attack that has a good chance of putting your Digimon to sleep. Unlike in ''Franchise/{{Pokemon}}'', sleep makes it pretty much impossible to escape and definitely impossible to attack, making your Digimon a sitting duck for Vademon.
** There's also Persiamon, used by the Game Master, whose special attack, Helter Skelter, ''dedigivolves'' your Digimon to its Rookie form, harshly slashing your stats. You can re-digivolve to that form immediately afterward, but good luck getting an attack in before Persiamon uses it again.
* ''DigimonWorldDawnDusk'' has Chrono Destroyer, only useable by the final boss. High Dark damage, plus it can easily put your whole party to sleep. Also, Royal Slash is a Holy attack so strong that, in the more active era of the metagame, any player with more than one digimon with the move would be disqualified.
* ''DragonQuest'':
** You'll be hard-pressed to find a veteran player of the franchise who ''doesn't'' hate Disruptive Wave with a passion. What it does is that once the enemy uses it, ALL your [[StatusBuff buffs]] are gone and there is NO way to block it, leaving you with a huge disadvantage if you spent the last 3 rounds casting buff spells, which you absolutely ''need'' in the endgame, and need a heal badly. Especially if the enemy can attack more than once in a single turn, which by the second half of the game, most of them can! First turn, Disruptive Wave = Goodbye all defense and power boosts. Second turn, you get hit with an ungodly powerful attack. [[LuckBasedMission Have fun getting around that]].
%%** [[spoiler:[[BigBad Corvus]]'s]] Magic Burst in ''IX''. Nothing more needs to be said.
** And what if there were an attack that could insta-kill your entire party 100% of the time with no need for any softening up. It's generally limited to earlier installments, but the Sacrifice and Kamikazee spells can do this. Once an enemy chooses to cast one of these, it's an instant Game Over. DragonQuestII even gave these spells to common Mooks, meaning that you could be wiped out because you looked at them funny.
* [[VideoGame/AtelierIris2TheAzothOfDestiny Palaxius]] has a lot of cringe-worthy attacks, but Crimson Split stands out. It can easily deal up to 300 to every character (which will most likely kill any character except for Felt and Gray) and once he casts it, it sticks around on the time bar to come up at least four more times '''while he keeps pounding you.''' And he's lightning fast and his other main attacks hit for even more damage. Luckily, Crimson Moon and Shadow Azoth are can only target one character.
* ''WildARMS'':
** The game has a take on [[FinalFantasy Bad Breath]] called "Arc en Ciel" which does some damage along with said status blast. Expect it to be used by [[DemonicSpiders the aliens]].
** [[BonusBoss Ragu O Ragla]]'s Volcanic Bomb in the first game, which deals 7000+ fire damage to all party members and is pretty much unsurvivable without absolutely insane amounts of grinding. The only other ways to withstand it is to make sure at least Cecilia is always equipped with a Goat Doll, or find Frog Badges, which nullify elemental damage.
* ''KingdomHearts'':
** In every ''KingdomHearts'' game, Riku has an attack entitled Dark Aura, wherein he'll become invincible and fly in quick dashes at your character. It does heavy damage and is very hard to dodge. It's even more devastating in ''Chain of Memories'', although you do have 0 cards that can break it. It also helps that in Reverse/Rebirth [[GameBreaker you can use it yourself]] ''[[GameBreaker as]]'' [[GameBreaker Riku]]. Also, Ansem's ultimate attack in Riku's last battle with him will almost certainly be fatal unless you dodge it.
** BonusBoss [[VideoGame/FinalFantasyVII Sephiroth's]] "Heartless Angel" attack, which drains all of your HP and MP in one shot. If you aren't able to interrupt it, you '''need''' the ability that lets you survive lethal blows with 1 HP (Most people assume it's a HPToOne attack because they haven't turned Second Chance off since they first got it ''way'' back in the beginning), but then you still have no MP to heal with. ''Ouch.''
*** Though you can turn it around with items, if you notice him beginning the move's rather long start up and either acknowledge you can't stop him in time or are already quite low, you can activate a healing item. Because there's an uninterruptable delay between using an item and receiving the benefits, you'll take the hit sure, but surviving is easy and you'll be quickly restored (to full even if you choose) just after.
** The second game gives Sephiroth an opening move that you have to block with an ActionCommand, otherwise you pretty much die. At least you don't lose ''that'' much progress if you mess up...
** [[BlowYouAway Xaldin's]] Wind Dragon in the ''VideoGame/KingdomHeartsII''. Multi-hit so it gets around Second Chance, does high damage, and is nigh-unavoidable. Thankfully, ref lega works perfectly well to shield you from it.
** ''BirthBySleep'' has the nameless [[BonusBoss optional boss]] [[RegionalBonus that the Japanese didn't get]]. This boss has Collision Magnet. Basically, the boss hauls you in with a rope and deals damage in mid air. First, it hurts. You need to be at a high level for this attack to not instantly bring you to your final Hit Point. Second, it's very fast and difficult to see coming, and unblockable. Third, it leaves you open for another attack, which can kill you if the rope managed to get you to one HP, without you being able to recover; even if you have Once More, because apparently the next attack, which you don't have enough time to recover for, counts as a separate combo. Your chance of victory is pretty much inversely proportional to how many times this boss decides to use this attack. This move was so bad that when the Japanese got their inevitable [[NoExportForYou Final Mix]], they nerfed this move to allow you enough time to dodge or heal, mainly to make the two ''new'' bonus bosses look challenging next to him.
*** AKA the "[[FanNickname Rape Rope]]." It's telling that the tracking for it is so good that if you use or spam your dash/dodge move (which has invincibility frames and moves you very quickly), the rope will just latch on your character as s/he's dodging ''continuously for several seconds'' if you're able to keep it up for that long, so that it grabs you as soon as you run out of invincibility frames.
** A lot of bosses in this game have some kind of inescapable stun-lock combo that in proud or critical difficulty will leave you with little to no health, requiring Second Chance/Once More and some form of healing ready. To make matters worse, HP isn't given by leveling up but instead is based on story events or through the HP up ability, and getting the latter can be a "LuckBasedMission" or require grinding through an optional area. Leveling doesn't really help your survivability because defense is pretty negligible in the higher difficulties and you even get less than the standard or easy difficulty. Some bosses with combos like this: [[spoiler:Terranort, Master Eraqus, Zack Fair, Braig, Vanitas, the Deep Space Boss, etc.]]
** The Armor of the Master and No Heart from the final mix of ''Birth by Sleep'' each have their own. AotM has a 20 hit combo almost guaranteed to reduce your HP to one normally, but if he's been allowed to enter his SuperMode by sapping you with his chain, it's a guaranteed kill. No Heart has his own variant of Heartless Angel late in his battle. It's uninterruptible but can be avoided, but if you either fall into one of his [[StandardStatusEffects slow]] traps or are right next to him when he rises into the air, you will be hit. This is also a guaranteed kill if he uses it twice, unless you have an item which you'll likely have used up [[MarathonBoss by then.]]
** Ever wonder why everyone hates [[spoiler:Terranort]] so much? Because he has a ''really'' annoying combo that stun-locks you and takes away most of your health, and even has two non-consecutive blows that can ''[[TheComputerIsACheatingBastard bypass]] [[LastChanceHitPoint Second Chance/Once More]]'' if your HP was already depleted to one by then. [[spoiler:It's the same combo that Terra uses himself when in Dark Impulse mode, but unlike Terra,]] he can pull this combo off ''at will'', and this makes it ''very'' hard to hit him. He also has [[spoiler:Ars Solum. How is it different than Terra's version of it? Well,]] it's unblockable, it is difficult to knock him out of it, and he can use it up to '''THREE TIMES IN A ROW'''. [[spoiler:Of course, when ''you'' use it, he just blocks the first hit of it, and Counter Hammers you.]]
** In addition, Zack performs Omnislash. You may feel pity for those hordes of enemies you murdered like that. It's used at the start of the battle, and can be used again during the battle. You are given a clue that tells you it's coming, and it's STILL hard to dodge.
** The optional boss from ''VideoGame/KingdomHearts358DaysOver2'', the Dust Flier, has an entire arsenal of these. First, there's a shockwave that will deal a random status ailment, a bombardment attack that comes fast and knocks you around like a ragdoll, AND the charge attack. The charge hits like three Mack trucks slamming into you one after the other. Glide makes it much easier to dodge, but you still have to deal with the Flier's [[MarathonBoss ludicrous HP count]]. If you can bring down this airborne bastard, you've earned the right to trash talk.
** The Mimic Master's laser attack in ''BirthBySleep''. He fires off two lasers, one bright and the other dark. If the dark one hits you, your field of vision is reduced and you lose the ability to lock on (as well as your Shotlock). It's also floor-level, so you need to jump over it and hope the bright laser doesn't catch you (although that just deals damage). Trying to run away from it? Don't bother, it takes up just about the entire field! And the Master is invincible for the duration of the attack.
** [[MakingASplash Demyx]] from ''VideoGame/KingdomHeartsII'' has a ''very'' annoying attack where he says, ''"[[MostAnnoyingSound Dance, water, dance!]]"'' and you have to kill ten water clones of him in ten seconds. Fail to do so? Game Over, with [[NonstandardGameOver no explanation as to why]]. It will probably be the biggest cause of frustration for you when you fight him.
** There's also [[BonusBoss Bonus Boss]] ''Kurt Zisa'' from ''VideoGame/KingdomHearts'' and his infamous ''Silencega'' technique, which is able to completely lock your magic -- until you destroy the two crystal balls in his hands. His hard-hitting physicals make healing very important -- for which you have nothing but items, which can't be shortcutted in this game. [[GameOver Game Over]] is imminent.
** [[spoiler:Anti Black Coat Nightmare]] in ''Dream Drop Distance'' has a particularly irritating one: he'll fire out a thin red line along the ground. If it hits you, it will lift you up in the air, ''[[HPToOne suck all but 1 HP out of you]]'', and ''scatter it around the arena as HP orbs!'' So, basically, you have to pick up all your health, ''while he's still attacking.'' Oh, and it's sometimes possible for him to use that attack just after he fires a barrage of weak shots. Immobile and on 1 HP, you have no chance of avoiding death in that situation.
** BonusBoss [[RunawayBrain Julius]] has a pretty big one too: he'll charge himself up with lightning, jump to the top of a tall building, then leap back down and bounce along the ground. It's really hard to avoid because of the AI's uncanny ability to know exactly where you're going to be when he jumps, so he usually ends up landing right on top of you. But that's not the worst thing about the attack. If he hits you, a random one of your commands will become greyed-out and have its reload rate slowed down so massively it's essentially taken out of the battle. Lord help you if he gets all your Curagas this way. Especially annoying is that, 9 times out of 10, the camera will lose your lock-on to Julius when he jumps, so you can easily get stomped simply because you lost track of where he was.
** The Data versions of the Organization battles in ''KingdomHeartsII [[UpdatedRerelease Final Mix+]]'' all follow a distinct formula, unlocking a very powerful attack (frequently called [[FanNickname desperation attacks]] by the fandom) once you damage them enough. The game will force you to deal with this, and sometimes will not let you defeat the boss until you have triumphed over this attack (Demyx's 'defeat 99 water clones in 30 seconds' and Luxord's 'Do you know the rules?' minigame are good examples: do what you like to their HP, but you won't win until you clear those challenges). If you're lucky, the boss in question will only use this desperation attack once (like Demyx and his final water clone challenge). If you're ''un''lucky, which you usually are, it will be added to the boss's pool of moves and reappear as often as the boss wishes. For example, Data Xemnas gets 'Can you spare a heart?', the move he used in the FinalBoss battle as a one-time scripted event/gameplay element (the one where he drains Sora's health and the player is forced to use Riku), as a desperation attack, that he can use as often as he pleases after his health dips below a certain point. The good news? Since it is no longer a scripted event but a regular attack, it can now be blocked by Reflect, or Limits(as Sora is invulnerable while executing a limit). The bad news? You had ''damn well better block it'', because Xemnas will drain Sora's health so fast this move might as well be a OneHitKill
** Xemnas as he appears as a bonus boss in ''Kingdom Hearts: Final Mix'' has an attack where he replaces all of Sora's menu commands with "Shock", which harms Sora, and "Release", which ends the move. Thing is, "Release" hops randomly and rapidly through Sora's commands, making hitting it without missing the timing and getting Shocked very tricky. In addition: the attack continually drains Sora's HP either way until "Release" is selected, Sora can't use magic or items to heal himself during this time. Oh, and Xemnas is still attacking. The move is initiated by a very fast melee attack that has little-to-no telegraphing time.
* ''RomancingSaGa:'' Death likes spamming Open the Gate a lot; it pretty much kills your characters outright or heavily damages them.
** Or even worse: Jewel Blaster, which deals magical damage, not physical, and is Quad elemental. The Jewel Beast even spams it every three turns instead of six when you whittle his HP down. The "Overkill" you frequently see after Jewel Blaster isn't just for show.
** However the most annoying one is Animate Dead, it's a permanent charm effect until the character loses all HP and dies again.
* From RomancingSaGa2: Rockbouquet's skill: Temptation - which charms all male party members.
* From RomancingSaGa3: Maelstrom (Insta-kill unless wearing armor that is water elemental), Fatal Mirror - which turns characters against each other, and Howling, which revives a fallen party member to attack once.
* ''{{Drakengard}}'': When fighting Furiae, there's an attack where she sends a dozen swords at you. And you have to dodge every single one, or you take full damage. It is avoidable, if you use homing fire, or the dragon's fully-powered LimitBreak, but [[GuideDangIt you probably wouldn't know that on your first try]].
** Manah in the canon ending was a pain in the butt. She had this annoying attack in the middle of the fight where she would summon rings that came from her abdomen, not too bad. However, after [[TurnsRed taking so much health from her]], she decides to summon the rings from all angles... Have fun dodging those.
* In ''VideoGame/PaperMarioTheThousandYearDoor'', Magnus Von Grapple 2.0 has the Audience Cannon, which deals ridiculous amounts of damage if you don't have plenty of Defense buffs active. To a lesser extent, X-Yux has the attack that it uses when it has four mini-X-Yux around it, which deals massive damage and immobilizes; if it gets a chance to use that attack, the player is in serious trouble.
** On the topic of the Audience Cannon, just like it says, it shoots the audience at you, for 3 damage per shot (which adds up to over 20 damage, which is almost always fatal in this game). And the audience is what you get your Star Power (essentially LimitBreak) from.
*** One completely unguarded sequence of the Audience Cannon would probably not be enough to kill you in one go, although the reality wouldn't be much better, considering that at that point you'd probably have roughly 50 or so HP, so it probably would kill you in two.
** The first ''VideoGame/PaperMario game'' has Tubba Blubba's heart attack (Though it can be dodged by using Outta Sight), General Guy's Lightning Bulb Shock (xan be stopped by breaking the bulb), Huff n Puff's Lightning Shock (Which makes him immune to most attacks for a few rounds and does massive damage), and the Crystal King's Ice Beam attack (which does light damage, but inflicts the Freeze status effect on you). Finally, Bowser has several attacks, but the most frustrating one is his jump attack, which removes an option to attack from your menu (If you lose the Jump or Item one, you are screwed).
*** Even the Koopa Brother's super attack is painful at the point you fight them. Also, Jr Troopa when you face him in the Shiver Snowfield, when he uses his magic attack which does about 8 damage (which is powerful for this series).
** The Shadow Queen's hands can use an HP-draining attack that deals 7 damage and heals 7 HP to the Shadow Queen, can be used once per hand, and ignores defense.
* In the ''[[VideoGame/MarioAndLuigi Mario & Luigi]]'' series:
** Two of Bowser X's attacks in ''[[VideoGame/MarioAndLuigiBowsersInsideStory Bowser's Inside Story]]''. One is where he becomes giant, chases you down, and you have to dodge both fireballs being thrown at you and others you have to jump over while escaping him. If you get hit three times, you get knocked out and he pretty much crushes you flat. His Shy-Guy attack is also very nasty: it's kind of like a reverse Koopa shell, and if you miss, the brother takes a lot of damage. He also has an attack where he shoots fire, you hit it back, he turns into a fiery shell, drops a ton down from the sky that you have to hammer away, and then falls on you. If you do deflect his fall, he'll then fly off to land on the other brother. And he goes fast.
** In ''Bowser's Inside Story'', the Junker seems like a fairly standard FlunkyBoss...until he sucks [[ButtMonkey Luigi]] up and sticks him inside one of his flunkies. The attack is unavoidable, unlike nearly every other attack in the game, and requires Mario to keep track of the Junker Can that Luigi is inside. In addition, the Junker Cans have tons of HP, they regularly swap Luigi around, and if Mario gets knocked out, you lose instantly.
** Dark Star/Dark Star X and its cloning attack. Generates five to seven copies of itself, then charges at each brother. However, the copies turn INVISIBLE a short while before they reach your character, and long enough that you have to guess when to strike too. Miss that attack, and you get hit quite hard, often by another copy following the first one. On the plus side, a successful defense will likely knock out the next clone headed for that brother too.
** The first attack used by [[FinalBoss Cackletta's Soul]] in ''[[VideoGame/MarioAndLuigiSuperstarSaga Superstar Saga]]''. Because if you don't dodge, you will die instantly due to [[HPToOne both Mario Bros. being reduced to one health point at the start of the battle]] (beforehand, you get blown up by a time bomb and eaten after a HeadsIWinTailsYouLose fight). This is, of course, if your speed is lower than hers. Otherwise, you can heal immediately after the battle starts. The chances of you being faster than her are pretty low, though, since you'd've had to have leveled up to around level 34 and/or really focused on speed when using the level up bonuses and/or be using a badge that increase your speed and/or used speed up stat items.
** There's also the giant laser/fire breath beam attack used by five bosses in ''Bowser's Inside Story''; Bowser, Dark Star, Dark Star Core, Dark Star X, and Bowser X. It does massive damage to the point of almost being a one hit kill, but is usually easily enough dodged. However, if one brother is knocked out, and the other guy is holding him, then it's quite difficult to catch Starlow and go to the top screen, likely killing whoever's remaining. Oh, and Dark Star does a kamikaze type charge at Mario/Luigi/Starlow if you dodge the beam, so if you forget to drop back down to the floor, it'll likely deal the same amount of damage the beam did.
** The Elder Shroob Princess' last form in ''[[VideoGame/MarioAndLuigiPartnersInTime Partners in Time]]'' has an attack where her tentacle legs start spinning around her, forcing you to jump over them. It's not too difficult when she only has two legs, but when she has four legs, it's almost impossible to dodge. Couple that with the brothers flinching for a short time after getting hit so that once you get hit, it's impossible to ''stop'' getting hit, and you've got one incredibly annoying attack. Oh, and of ''course'' it does a ton of damage.
** In ''[[VideoGame/MarioAndLuigiDreamTeam Dream Team]]'', there are quite a few attacks like this:
*** One is Earthwake's flying hammer attack, where the boss turns into a gigantic mallet you have to dodge or smack away... multiple times. In Hard Mode, he even does about 10 of these swipes in one turn, so you can literally go from having full health to being dead just because you couldn't dodge/block a single annoying attack.
*** There's also Pi'illodium's hammer anvil style attack, where he flies off screen and comes down like a hammer on a Bro's head... at about 90 miles per hour. It's entirely trial-and-error-based, since you likely don't have the split-second reaction times to deal with it as it's about to hit, and even when you know, the timing is still rather unfair (and it can also stun the character it hits to stop them moving)
*** There's also two of Antasma's attacks in his final battle: the bat swarm and the rings of death. The former summons a huge flock of bats that fly across the level and have to be dodged (and due to the misleading depth/graphics style, you can't easily tell which ones are heading for you to begin with) or you risk [[DreamWithinADream falling asleep]] and having to escape an endless gauntlet of obstacles, while the latter has him throw rings of exploding orbs at Mario as he runs away, with you having to be in the middle of them and then jump the shockwave to avoid. The latter is arguably better if you fail than win, since being hit by the shockwave actually builds up to more damage than just being blown up to begin with.
*** The giant Mount Pajamaja volcano boss's ramming attack is less an attack than a free ticket for him to take out 1/4 of your health. He only does it once at a time (thank goodness), but if anything, it is even ''harder'' than Earthwake's hammer attack to counter. It requires repeated quick strokes on the touchscreen to defend against, and most of the time, these won't even register enough to matter.
** The [[DemonicSpiders Beehoss]] have a counterattack they use whenever they're hit by something, which is to summon a swarm of bees that's hard to jump over. Counter-counterattack the bees by jumping on them instead of over? They'll hit you with an unavoidable counter-counter-counterattack. (Dear Zeekeeper, it's like [[MarioAndLuigiSuperstarSaga Prince Peasley and Fawful]] all over again.) Their regular attack works the exact same way, and while the tells are in the background (for the Bro. they target), sometimes they don't show properly and it's up to luck.
* In ''VideoGame/SuperMarioRPG'', the Breaker Beam attack used by Axem Rangers and later Gunyolk. Luckily, it requires charging for a turn or so, so you won't get nailed by it twice in a row. The charge-up also allows you to defend for the next turn so you'll only take half damage.
** Some [[OneHitKill instant-death]] attacks can count as this, especially the completely unblockable ones. The less powerful ones can be blocked by certain accessories, and can also be blocked by proper timing. How well you time your defense is the difference between surviving it with only 1 HP and remaining unscathed.
** When Smithy is in his wizard form, Sword Rain, Spear Rain, Arrow Rain, and Dark Star count heavily. Also, his chest form uses different status effects on you, and Tank Form has an instant death attack.
** [[MeaningfulName Yaridovich]] and his [[KillItWithWater Water Blast]] has downed many a low-level run player.
** Carni-Kiss is a ''really'' powerful attack. It's not a OneHitKill, but unless you explicitly do some grinding, it may as well be. And since it's ''technically'' a magic-based attack, you can't guard against it. A lot of the already-tough enemies like the {{Chest Monster}}s and [[StrongAnts Shogun]] pack it, which doesn't help matters. Very ironically, by the time you fight the [[MoreTeethThanTheOsmondFamily Chomps]] that know it, it's not as dangerous.
** Certain spells such as Petal Blast and Aurora Beam will damage your entire party as well as have a chance of disabling each member. In the worst case, your entire party can be disabled until each one either dies or the RNG decides that you shrug it off. At least Mushrooming lets you recover HP every turn.
** [[BonusBoss Culex]] and his elemental crystals have nothing but stupid-powerful attacks (like the aforementioned Water Blast), but none of them compete with his one physical attack. He doesn't even move to attack you, all that happens is you instantly hear a slash and one of your characters takes about 150 damage at a respectable level (for comparison, all of your characters are barely below 200 HP, and most of the magic attacks will only deal 50-70 at that point). And because of its unpredictability, it's pretty much impossible to block unless you instantly press A as soon as it's his turn to move. Even when you [[GameBreaker put the Lazy Shell on the Princess]], which lets her take little to no damage from every attack in the fight, this attack will still deal about 50 to her. There's also his Dark Star special as well, which can pose a serious threat even to a Lazy-Shell-equipped Toadstool. At least it's only single-target.
* ''VideoGame/ChronoTrigger'' has several, though the NewGamePlus eases the pain of some of this:
** Masa and Mune's combined form has an attack, signaled by the message "Storing Tornado Energy." and two turns later "Pain...", that does over 100 HP in damage and targets the entire party. At the time you face them, it will most likely knock your characters into the low double-digits and force you to waste a turn healing them. Even worse, the [[GuideDangIt single obscure hint given by a random NPC that tells you how to stop the attack]] was mistranslated into uselessness in the original SNES release of the game. [[spoiler: Attack Masa&Mune with Crono's Wind Slash attack (mistranslated as Slash in the SNES version) while he's charging the attack, and it'll dissipate the "Tornado Energy". Problem being that the man in the SNES version talks about you using Slash on Energy Whirls, whatever those are]].
*** EnergyWhirls are the enemy save points that appear in the pits in Magus's Castle; this isn't actually a case of mistranslation; the advice is entirely sound, it's just that the enemies in question don't have a name on the in-game combat screen. Although that NPC's advice DOES function equally well on Masa & Mune, that's merely a happy coincidence.
** Magus risks casting a spell! (Signals that he's about to cast Dark Matter, his most powerful spell)
*** [[BarrierChangeBoss Barrier Change]]: Only Shadow damages! Magus' Barrier Change spells not only make him immune to all magic except the corresponding element, they also hit the entire party ''hard''. And he does them a lot. Shadow is the worst, however, not only for the damage, but also because the only character you have with shadow attacks at that point is Robo, who is somewhat redundant with Frog and whose only shadow magic attacks are relatively weak, multi-target lasers. Even if you do stick him in the party (generally unwise, due to his generally poor performance in this fight), it just means that his fire barrier will mess you up instead, as you won't have anyone with fire attacks.
** Destruction rains from the heavens! (Lavos shoots his Spines of Death at you)
** Lavos Core's "Grand Stone" attack, guaranteed to reduce you to single HP digits, if not kill you outright (but you can use this against him if you have Frog and/or Ayla in your party) Also Dreamreaver, which is basically the same attack, just a magic variant. Chances are it'll do more damage to your party than Grandstone. On the plus side, his attacks can be predicted. If you pay attention to the shifting background, you'll see his attack corresponds to the time period showing. This way you can at least prepare for the the pain that's to follow.
** Any attack involving both of Giga Gaia's hands. The problem isn't the attacks per se, it's that, on a first run, Giga Gaia is almost guaranteed to go first and act twice in a row, and the Double Handblaster/Dark Plasma combo WILL TotalPartyKill you if you aren't prepared (which boils down to having either insanely high resistance or outright immunity to at least one of the two elements he uses).
** Queen Zeal's Hallation, which also [[HPToOne drops the party's health to 1 HP]]. If that isn't enough, attacking her hands in her OneWingedAngel form causes them to counter with Hallation ''and'' MP Buster. Good luck recovering from ''that''.
** [[ThatOneBoss Son of Sun's]] flare and purple laser both take a huge chunk of HP (potentially over 300) out of pretty much any character who isn't appropriately equipped. While only Flare targets the entire party, its AI loop places the attacks right after each other.
** The [[UpdatedRerelease DS version]] adds a couple new ones, such as Scintillation. Thankfully only used by one boss, this attack deals an absurd amount of damage to the whole party - absurd meaning roughly 400 at maximum magic defense and with a Barrier that halves magic damage, in a game where the HP cap is 999. And if you have a character with less than maximum magic defense or remaining HP, better hope the boss doesn't recast it while you revive said character on top of healing your party.
* Then, we got ''VideoGame/ChronoCross''.
** [[ThatOneBoss Miguel]] and all of his white magic, but especially [=HolyDragSwd=], which is so tremendously powerful it can almost one-shot anyone who isn't innately white. And he likes comboing it with [=WeakMinded=], a magic-defense debuff. And if he manages to turn the field white...
** Pretty much every element used by the Tragediennes. This is the entire point of them; if you can survive their initial volley of elements ([[GuideDangIt and had the foresight to bring the right traps]]), you can acquire stuff like Volcano and [=BlackHole=] way ahead of schedule, essentially breaking the game wide open.
** [=MegaStarky=], otherwise a fairly easy boss, will smack the party with an [=UltraNova=] when his health drops far enough.
** [=ExhaustGas=], used by the [[BossInMookClothing Highwayman]] in the Dead Sea, blinds the entire party and is ''very'' accurate. You'd better have some [=BlackOut=] or Purify elements allocated, because you're not winning this fight with everyone blinded.
** [[spoiler:[[BonusBoss Dario]]'s]] attacks are pretty much all crazy powerful, but special mention goes to one in particular. If you use any kind of white element in the battle, he'll counter with [=ConductaRod=], a ''devastating'' black tech. [=Dash&Gash=] does way less damage than [=ConductaRod=], but does it enough to OneHitKill a non-black innate character.
** The [[spoiler:Dragon God]] gets access to pretty much all the elements in the game, including nasty ones like [=BlackHole=] and [=UltraNova=]; when you add that to its already staggering magic attack, you've got a recipe for a party wipe. You can stop them with traps, if you know they're coming, but if you don't know about them, it's a ''long'' road back to Marbule.
** [=ForeverZero=], a tech that is insanely powerful and can easily kill white innate characters. Fortunately, it's a tech learned by a playable character. [[spoiler: Unfortunately, it happens to be Serge with Lynx body and Dark Serge (Lynx) ''also has this tech and will use it against you''.]] [=FeralCats=] isn't as painful as [=ForeverZero=], but still hits hard.
* [[spoiler: Luther]]'s Insanity Prelude in ''StarOcean3'', an unblockable red flood that covers most of the battlefield. Assuming you aren't about thirty levels overleveled with equipment you shouldn't even have, its multiple shots will kill your entire party easily - you can only avoid it by standing in certain corners of the battle map - and forget your AI-controlled party members going there, you have to guide them all manually. (Alternatively, you can stun him out of casting it.) Any [=SO3=] message board is inevitably hit with 'how do I dodge Insanity Prelude' more than a few times.
** While several of the NintendoHard extra bosses have similar moves, the final three of [[ValkyrieProfile Lenneth, the Etherial Queen, and Freya]] are by far the worst. With Lenneth and the Queen, you at least have a slight chance of making it to the edge of the screen to dodge Nibelung Valesti and Celestial Star. Freya, however, will spam Ether Strike again and again without warning and cannot ever be disrupted. You only hope is certain stunning items which buy you a total of, oh let's say, three seconds, before she's back on the offense.
*** The trick with Ether Strike is to make sure she's nowhere near the center of the battlefield when she uses it. The move is slow enough that you can make it to the other side of the field, so it's in your best interest to simply keep her pinned on one side of the battlefield by luring her there. The first minute or two of the battle can be pretty rough though, as you must survive her attacks long enough for her to GET to the battlefield's side. Or alternatively, abuse [[GameBreaker Fayt's Side Kick]] which has invincibility frames and lets him completely dodge it...
* Fadroh in ''BatenKaitos'' is a CurbStompBattle. Who is curb-stomping who? That depends entirely on whether or not Fadroh buffs himself with Orb of Magical Offense.
** [[spoiler:Geldoblame]]'s Forfeit Your Life, a OneHitKO. And he likes to use another attack called Seal of Evil, which paralyzes a character, meaning they ''can't defend''.
*** The Angel of Darkness also likes paralysis, but couples it with an attack that steals your HP. When he TurnsRed and moves twice per turn, it's not uncommon for him to heal faster than you can damage him.
** Agyo's A-Up Pentagram. Not a OneHitKill, but might as well be.
** The Holoholobird's Wingflail, which knocks the whole party down and breaks any combos you've set up.
** The Godcraft's hail attack. It hits the entire party for tremendous damage, enough to cut over half their health down.
*** In what might be either a bug, a programming oversight, or just the dev team being sadistic, that attack (and several others used mostly by bosses) are ''lethal'' if you have a party member knocked out. Essentially, they're programmed to hit the whole party multiple times, but the targeting is random, i.e. the attack might not even scratch Guillo, but knock Milly out and put Sagi in the red. However, if one of the party members is down, the attack only has two targets, but it still hits the same number of times, meaning the two remaining are in for a world of hurt.
** [[spoiler:Wiseman]]'s Cast Off Your Carnal Robes. Doesn't do too much damage, but it knocks the whole party down, destroys any magnus you have equipped, and breaks your combos. Just to add to that, he steals your magnus power with his regular attacks, so you'll be seeing his specials a lot.
** Magnus of Life, used by [[spoiler:Verus-Wiseman]]. It hits the entire party, hurts like hell, heals the boss, and inflicts all status ailments. Nothing's better than losing just because everyone's blinded or frozen.
* When you see the eponymous boss of ''VideoGame/{{Diablo}} II'' step back, ''run like hell'' because he's about to unleash [[http://www.infoceptor.net/strategy/diablo2/walkthrough/mission24/shot1.jpg a brutal stream of red lightning]] that can sap your health in seconds. This was nerfed in ''Lord of Destruction'', but it's still very damaging: it can still take most of your health in a single second, if not actually kill you. Diablo's ring of fire, his other attack, hits everything in every direction even when he's not on the screen, making it essentially unavoidable.
** There are various bugged monsters that can nearly instantly kill you. The hardest two are poison vipers, whose poison javelin is bugged and deals their regular attack damage 25 times per second on top of its poison damage; and gloams, who seem to deal 256 times their intended damage.
* Some enemies in ''VideoGame/DragonAgeOrigins'' will use the same GameBreaker abilities that you use all the time. It's no fun at all being on the receiving end of a Crushing Prison (continuous damage and paralysis), Overwhelm (essentially a physical version of Crushing Prison), Scattershot (ranged mass stun that's almost impossible to resist), or "Curse of Mortality" (negates healing and does continuous damage). That last one is almost guaranteed to result in character death (which is extremely annoying if you're going for the "No Deaths" achievement) unless it's dispelled. Some bosses [[spoiler: such as the High Dragons]] also have grab attacks that can instantly kill any of your party members except for the unique ones like Dog and Shale, which makes those two good choices for fighting against [[spoiler: Flemeth and the High Dragon]]. You will also quickly hate the Revenant's "Pull" attack when it brings your precious mage or archer within range of that {{BFS}}.
** There is only one thing worse than Pull: ''Mass'' Pull. Nothing beats getting ''all'' your party members yanked off their feet and into melee range, often interrupting vital spells or talents.
** BLOOD WOUND. It's like Crushing Prison, only for your whole party at once! Very likely to end your game. Always shoot the blood mage first.
* The LimitBreak of the final boss in ''VideoGame/TalesOfGraces'' kills ''at least'' two of your party members, unless you're fighting on easy mode. If you're unlucky, it will obliterate your entire party.
** Also from ''VideoGame/TalesOfGraces'', there's [[spoiler: Emeraude]] with her Killing Field spell she always uses immediately after entering Arles Rise, which hits the entire battlefield, and is likely to put everyone into critical HP or KO them on higher difficulties if they don't defend against it (Which the AI is quite prone to).
** VideoGame/TalesOfSymphonia has Retribution, which [[SequentialBoss the first form of the]] FinalBoss uses -- ''and then adds to its AIRoulette'' -- when you get him down to about half of his HP. It gives two random status ailments to each of your party members. The catch? It's tricky to stop it.
** [[VideoGame/TalesOfVesperia Fly, o Holy Sword!]] [[http://www.youtube.com/watch?v=ZhT8Z28YItQ Brilliant Cataclysm!]] Cue PartyWipe.
*** [[http://www.youtube.com/watch?v=JihtAfbHuV0 Toll the beginning of time... Big Bang!]] This one isn't ''as'' bad, since he may use it once or twice and that's easily countered by a Treat. But if you fight the optional boss? I guarantee you'll be sick of [[MostAnnoyingSound hearing]] that. And [[http://www.youtube.com/watch?v=MUsQiLW5aF8 he has something else in his arsenal, too.]] (And yes, the final boss ''heals''.)
*** Big Bang is even worse in the PS3 version, as it actually has the capability of ''[[TotalPartyKill killing you]]'' on higher difficulties. And it can do upwards of 80,000 damage on Unknown mode (meaning even Flynn's [[GameBreaker Energy Coat]] can't save you).
** In ''VideoGame/TalesOfTheAbyss'', most enemy Mystic Artes are avoidable, assuming they [[TheComputerIsACheatingBastard don't pull one out of nowhere without warning]]. Arietta's, though? Big Bang hits ''everyone'' completely regardless of where they are on the field.
*** The optional bosses get pretty bad too. Philia has Big Bang and Sacred Penance which ''both'' are usually guaranteed to hit you. Reid also can use Aurora Wall. Hits everyone nearby, which isn't bad, but it ''REVIVES'' the fallen comrades. And Nebilim... Big Bang, Mystic Cage, Fortune's Arc, Indignation, Rending Saber, Radiant Howl, and the worst one yet, the only one she ''didn't'' steal from your party members, ''Fragmented End''.
** In ''TalesOfTheWorld: Radiant Mythology'', Widdershin can use Eternal Finality ([[VideoGame/TalesOfEternia Nereid/Shizel's ultimate attack which required a specific counter or it'd be an instant game over as it dealt 20k damage and healed Nereid completely]]) once he drops to half health. The good news: It doesn't heal Widdershin completely and does a lot less damage. The bad news: it still hits for 5000+ damage AND there's no Aurora Wall to counter it in this game, so you know it's gonna hurt.
* The evil storyline of ''[[VideoGame/ChampionsOfNorrath Champions: Return to Arms]]'' has Mithaniel Marr as the FinalBoss. And one of his attack sequences involves throwing you to the ground while dealing immense damage, and then attacking several more times while you can't move.
** This only applies in single player mode, however, with two or more this attack is a great way to get a shot at his back.
* In ''{{Runescape}}'', the final boss of the quest Nomad's Requiem, the eponymous Nomad has an attack in which he freezes you in place, then charges an attack that does damage equal to your maximum health minus one hitpoint. There's no way to avoid it, and unless you have maximum health when it hits, you die, instantly. That was the case until "damage soaking", which made this attack less scary[[labelnote:Mechanics]]When you would be hit for 200+ damage, the part of the damage which is 200+ is reduced by several-severalteen percent, based on your armour. This usually is useless, but against Nomad, which can hit for 750 and for MAXHP-to-One, this actually makes some visible impact[[/labelnote]].
** Most of the Dungeoneering bosses are just normal bosses with One Attack that makes them special. The Luminescent Icefiend is notable - at every 25% HP milestone, it becomes invulnerable, then sends down a painful icicle rain attack[[note]]that takes just about two seconds to fall down and is fired at a rate of one per 0.6 seconds, which is as often as possible. The attack doesn't deal much damage per hit, but if you get hit by one, you are thrown aside and generally assured to be hit by a dozen more. Luckily, it stops before you die. The only way to avoid it is to keep moving - if you stop for even a second, bang. The fact it targets an area and not a player is especially frustrating - if you're in a large team, then crossing paths with someone can mean being hit by an attack meant to hit him[[/note]]. Night-Gazer Khighorahk has a melee attack that hits everyone around him for heavy damage, too - if you don't run away when you see it charging, you take heavy damage. Saggitare's arrow rain works the same way.
** Even player-killers have their own [[ThatOneAttack That One Attacks]], such as Ice Barrage, which freezes the target in place, but can be cast over and over, lengthening the effect. It basically leaves melee fighters helpless.
* In ''VideoGame/{{Mother 3}}'', [[spoiler:Porky]] has an attack that he, thankfully, rarely uses where he "coughs something up." It is the equivalent of using Offense Down AND Defense Down against your entire party '''3 TIMES,''' and can be dangerous if you don't have enough PP to raise your stats back up.
** From VideoGame/EarthBound, you have the Kraken's tornadoes. They do huge amounts of damage, hit everyone in the party, and can't be nullified or deflected like his other attacks can. Also, buffs won't help you; the Kraken's only nonoffensive attack neutralizes any buffs or debuffs you might have cast.
** Also, Diamond Dog's 'glorious light' attack. Anyone without certain equipment will most likely get paralyzed, killed, or confused. You're in trouble if you missed the Sea Pendant at the far end of the Lost Underworld.
** Made even worse when [[spoiler:Ness's Nightmare]] uses it. If Ness has a Night, Sea, or [[RandomDrop Star]] Pendant, it'll just waste a turn. If you gave that to a weaker party member, then you'll be up against an attack with a good chance of either being a one-shot kill, paralysis, or confusion. Against a DuelBoss, that's a very bad thing.
** The preferred attack of a few {{Metal Slime}}s from both games [[spoiler:(Criminal Caterpillar and Master Criminal Worm from VideoGame/EarthBound, and the Beanling and Black Beanling from ''VideoGame/{{Mother 3}}'')]] is a low-level PK Fire, which hits your entire party ForMassiveDamage the first time you can possibly fight them.
** There are a lot of attacks in VideoGame/{{Mother 1}} that you will hate. Dehydration attacks, which lower your offense ''and'' defense at once, are nasty, as are last shot and PK Beam Gamma attacks which can instantly kill someone. Was it mentioned that you have to ''go back to town'' to revive a party member? And that the instant-kill attacks [[TotalPartyKill can be used by enemies]] ''before'' [[TotalPartyKill you get your second party member]]?
* In ''VideoGame/MegaManXCommandMission'', Ninetails has an attack called Nine Fragments. It deals out a fixed 999 damage nine times. It is very hard to survive this (unless you're [[OneWingedAngel Ultimate Armor X, Absolute Zero]] or Stealth Mode Axl), and it rarely misses.
** You can't mention the Tail clan without talking about Annihilator Hadoken, which deals an insanely high amount of damage (sometimes reaching into the tens of thousands). Also, if it doesn't deal enough damage to instantly kill a party member, it has a high chance of inflicting Crash (at least while fighting Ninetails), which means that they'll still die.
** Epsilon has Meta Crash. It's an HPToOne attack that never misses (unless it targets Stealth Mode Axl). Epsilon ''will'' open the fight with this move, and he spams it after he enters his [[OneWingedAngel Eject form]]. He likes to follow that up with Nova Thunder, which deals immense Electric damage to everybody.
** Silver Horn's Liquid Coating doesn't do any damage, but it is a ''very'' irritating move. After using it, his defenses skyrocket, and he has a chance to arbitrarily guard any attack, so even Thunder - his weakness, what he's ''supposed to take more damage from'' - does minimal damage to him when he blocks. It also allows him to use Pressure Abyss, an Ice attack that is ''always'' a Critical Hit and, unlike most critical hit attacks up to that point, doesn't have any accuracy reduction.
** Atomic Fall, used by the Meltdown. If you can't kill it before it takes three turns, you're looking at a suicide attack that does high 4-digit damage to your entire party.
** The combo of Break Shield and Double Iron used by the Einhammers in Chapter 2. If the Einhammer is the last enemy alive, it sacrifices its defensive stats and from then on will ''only'' use Double Iron, an attack that takes off about 25% of X's health in one strike. The Zwei Hammers later in the game can use this same combo, but it's worse the first time around because at that point X is the only party member you have, whereas later on you have a full party to mitigate the damage of Double Iron.
* Bass from VideoGame/MegaManBattleNetwork 4 and onwards gets his Buster Rake upgraded. Instead of shooting rolling shiny balls down the rows, this one actually rakes your side of the field several times, does not provoke MercyInvincibility, is insanely hard to dodge, and the faster he gets, the harder it is to dodge, all the way up to being completely undodgeable. Sure, a single Panel Grab chip will eliminate this, but few people actually bother with it. And in his final forms, every hit deals over a hundred damage, which piles up fast. No matter how high your HP counter is, it's all reserved to tank Buster Rake. He also LOVES to finish off low HP with this.
** In Battle Network 5, Shademan's attack in Liberations has practically infinite range; it can hit anyone next to a Dark Panel. It doesn't matter if he's still within locked panels or if you're on the opposite side of the map, ''he can still hit you''.
** Dark Cloud. The damage it does isn't so bad, but it paralyzes anyone in the attack's range, meaning that you have to wait a phase until they can move again. God help you if you tried to rush Cloudman with all your Navis.
** Rewinding to Battle Network 3, there's Kingman's Plan B. He uses an Area Grab to reduce your running room, moves his Pawns as close to you as possible, and summons a Knight in your side of the field. Let him live long enough, and he'll do it again, this time using only one Pawn and ''two Knights'', again in your field.
* Players of ''YggdraUnion'' often cringe when the word 'Genocide' is mentioned. It's the signature move of ThatOneBoss Gulcasa which kills off his allies, giving him an exponential boost in power for every unit killed. To make matters worse, this move shatters your meter, preventing you from using any cards to defend yourself with. Finally, if he manages to take out all your characters with this move during a skirmish, your morale takes quite a plunge. And you have to face this guy quite a few times.
** Players of ''VideoGame/BlazeUnion'' may cringe when the word 'Jihad'[[note]]English-speakers that played Yggdra Union may call it Crusade instead[[/note]] is mentioned. It's the signature move of Ordene, which immediately causes him to win if he is alone and at MAX Rage Rate. Oh, and you can't block it with Shield Barrier. Good luck with that. [[spoiler:There's a way around it; he won't attack Aegina with it.]]
** BonusBoss #367's Judgment Zero. In her first form it's barely worth mentioning, but in her second form it is practically guaranteed to do Overkill damage, which is an instant loss for you. Like Jihad, it is unblockable and non-elemental, so if she gets it off you ''will'' die. It's a lot more manageable in Blaze and Gloria, where it will only deal Overkill damage if Alanjame or Gariored is alone.
** Gloria Union has Megiddo. It's basically Crusade with a smaller Morale damage bonus, but its user doesn't have to be alone. Once again, it's non-elemental, and Shield Barrier and the new anti-Skill skill Magic Shield do nothing against it.
* ''CityOfHeroes'':
** Many players have learned to fear Ghost Widow. Her darkness based powers are tough, but manageable. Where she really hits you hard is her signature attack ''Soul Storm'', which is a magnitude ''100'' hold that deals continuous damage for several seconds. The average magnitude of a hold (including the player version of Soul Storm) is ''3''. Any character hit with this has a very high chance of dying.
** A close follow up (also from Ghost Widow, though it's available to custom [=AVs=] as well) is Dark Regeneration. Dark Regeneration is a mild [=AoE=] attack that grants hitpoints depending on how many foes are successfully hit. On a heavily Melee oriented party, this is bad. On a party with one or more Masterminds, this is ''very'' bad. Thug and Demon Summoning Masterminds should be particularly wary, as their signature powers (Gang War and Hell on Earth, respectively) amount to what is basically a full heal if used against a Dark Armor wielding Archvillain.
** The Dilemma Diabolique trial had several attacks. The Sentinel of Mot had a (thankfully optional) power that created a difficult to see white circle around him. For every person within this circle, it would rapidly regenerate hit points.
** The Underground trial had several instances of annoying. The War Walkers had targeted abilities that grew in power depending on how many people surrounded the marked player. Don't notice and forget to run? Total wipe. And this part is an EscortMission. Thankfully, most groups left the NPC upstairs. What was even more annoying was the timed battle against the Avatar of Hamidon, which featured an automatic Confuse effect that required ''multiple'' applications of Status resist powers to avoid. If someone didn't notice the "confused" tag on their status bar, they could end up murdering the entire raid, or worse: HEALING THE BOSS.
* Thresher maws in ''VideoGame/MassEffect1'' continually burrow into the ground and reappear somewhere else. That "somewhere else" can be ''directly under you.'' Instant game over. That isn't even getting into its ''actual'' attack, spitting out acid which completely ignores your shields and take off more than half of the [[CoolTank Mako's]] hit points (if you're fighting on foot, the acid attack is very likely to insta-kill). The general strategy people recommend for thresher maws is "run the hell away."
** Biotic enemies love to spam an ability that knocks Shepard down, leaving him/her completely helpless. Fighting against multiple biotics means that you can be stuck to the floor for quite a while, watching your health whittle away without being able to do anything about it (even ''pause the game'').
** The rocket drones in the Luna base frequently fire extremely powerful rockets. They're almost guaranteed to be a OneHitKill unless you have high-level Immunity or very high shields.
* In ''VideoGame/MassEffect2'' there are a ''lot'' more examples of this trope. There are the [[DemonicSpiders Scions]], whose Shockwaves tear your shields to pieces and ignore cover. There are the [[ThatOneBoss Praetorians]], whose Death Choir attack decimates anyone within blast range and fully recharges their Barrier. There's the Oculi, whose energy beams stagger you and deal massive damage. There's [[PeoplePuppets Harbinger himself]], who's fond of using a Singularity attack that knocks you out of cover so he can bombard you with Warp blasts.
* In ''VideoGame/MassEffect3'', Banshees have a homing Warp attack that inflicts lingering damage, a Nova-like attack that strips shields but is unlikely to kill, and a claw swipe. These are all annoying, but manageable. They also have a OneHitKill [[ImpaledWithExtremePrejudice melee attack]], coupled with a [[TeleportSpam generous]] definition of "melee." Other enemies, like Phantoms, Brutes, and Atlas mechs, have instant-kill attacks, but they can only use theirs as a follow-up to a regular melee attack, while the Banshee can grab you the moment you enter its InstantDeathRadius.
* It's not unheard of in VideoGame/WorldOfWarcraft, either. Deathbringer Saurfang, for example, has an ability called "Mark of the Fallen Champion". Players marked by this ability will take massive damage for the rest of the fight, and if they are killed, he will heal himself for a significant amount. You basically just have to [[LuckBasedMission pray]] he doesn't target a SquishyWizard, or you're screwed.
** The bosses of Mount Hyjal seem to have this fairly often. Rage Winterchill, the firt boss, has a Death and Decay that does 15% of each victim's ''maximum'' health per tick. Azgalor has an attack that targets a player every 45 seconds and kills them after a 20 second debuff expires. Archimonde can fling players into the air with Air Burst, and they must know how to use the Tears of the Goddess correctly, or they will fall to their deaths.
*** Because of multiple That One Attacks coupled with his status as ThatOneBoss, Archimonde was considered unfarmable by some servers, even after he was nerfed for ''Wrath of the Lich King''.
** Toward the end of Wrath, if you mentioned the word "Defile" in trade chat, everyone knew what you were talking about. To those not in the know, Defile is an area of effect attack used by the Lich King. He frequently casts it beneath a random player, and its damage ''and size'' increase every time someone stands in it even for one tick. If your 25 player raid group mismanages this ability? [[TotalPartyKill You're dead]]. To make matters worse, he has ''another'' attack that is handled by ''stacking close together'', and since both attacks are on a slightly different timer, they occasionally come out back-to-back. Defile is the reason that, even at the end of the next expansion, when a single character has ten times more health and can output more damage than an entire raid party used to be able to, it still takes a coordinated effort to defeat the Lich King.
** Even going as far back as classic, [[EldritchAbomination C'thun]] had his infamous Eye Beam attack, which would blast a player for respectable damage before bouncing to another, ''its damage doubling each time''. Many stories were recorded about entire 40 man raid groups entering the room at once and getting slammed by this, the very last victims suffering hits in the ''hundreds of millions''. This attack may qualify in-universe for Memetic Badass status, to the point where people have sat down and thought up strategies to maximize its damage, such as taking 40 hunters with 40 pets and having them drop 40 Snake Traps.
** Garrosh Hellscream has [[spoiler:Touch of Y'Shaarj]], a MindControl effect that he puts on certain players. While afflicted players can be broken out after taking enough damage, they will mainly attempt to put the mind control on other members of the party, and if they get off a cast, the situation will spiral out of control. Once Garrosh gets enough energy, it gets Empowered, resulting in the mind-controlled players having more health and becoming immune to stuns, making it harder to interrupt or free them.
* In ''VideoGame/TheLastRemnant'', certain enemies have an attack called Curse which, when your party is afflicted by it, has a 50% chance of killing you instantly. While you can also give the status effect to enemies, [[TheComputerIsACheatingBastard guess which one of you will die from it.]]
* Two bosses in ''VideoGame/PuzzleQuest 2'' have literal OneHitKO moves:
** The final boss has "Subjugation", which will cause your character to surrender the battle, no matter how many hit points either of you have left.
** BonusBoss The Yeti has "Crushing Blow", which does 999 damage (which is about five times the HP you'll probably have when you first confront him).
* ''Franchise/DotHack'' has several. The first game has Skeith's "Judgment", which hits the whole party, is impossible to avoid or block, and hits for roughly 70% of your health. Then there's Macha's attack which inflicts Charm on the whole party... which means they beat each other up until it wears off, and you can't heal it because it hits the ''entire party''. Then there's Tarvos's Cursed Death Play, which only targets one character, but cannot be avoided and is a guarenteed OneHitKO. All of the Phase bosses are also capable of Data Drain, which only targets one party member but destroys their HP and infects a number of status infections. And it can be spammed.
** In ''VideoGame/DotHackGU'', there's Azure Kite's "Azure Tiger Claws". It is possible to block this, but it requires some very tricky timing: the attack is timed so that if you do a full combo (which is what most players instinctively do), it will hit you during the lag between attacks. Later, in Redemption, there's "Chaos Gehenna", used by Cubia Beta. Once his HP hits around 20-30%, he simply spews a long stream of Gomoras at you. It's next to impossible to dodge, and harder to destroy all of them without taking damage. Also, since this is an Avatar Battle you cannot heal, and if you lose you must restart the battle from the Cubia Alpha phase. Chaos Gehenna is so bad that it can arguably make Cubia into ThatOneBoss.
* Orjugan, ThatOneBoss of ''VideoGame/{{Ys}} VI: The Ark of Napishtim'', has a deadly WaveMotionGun style laser blast, which is difficult to dodge without also getting hit by his CombatTentacles, which [[OneHitKill can kill you in one hit]] on Hard and Nightmare difficulties.
* There are more than one here, but the Megiddo technique from ''PhantasyStarIV'' deserves notice. It was a staple attack-all ever since the second game, and suddenly, the final boss has it like your main character. (In addition to sucking up souls or whatever before performing.) Absolutely devastating when the boss decides to remove your buffs, and man can it spam like there's no tomorrow.
* ''VideoGame/BreathOfFireDragonQuarter'' has Malefactor, used by [[spoiler:Dragonized Bosch]]. What it does is afflict the party with every status in the game. So unless you're going to unleash everything with Ryu's powers, you're gonna want to have even one person with immunity to bail the others out (if not more).
* Late in ''VideoGame/SeikenDensetsu3'', many level 3 techs when used by the enemies, such as Split-Image Slice or Vacuum Sword, will hurt everyone in the party for around ''80-90%'' of their max HP. These attacks can take a fully healed party to critical, or a party in decent shape to [[TotalPartyKill dead]]. If two of these are used on you in a row, [[{{Unwinnable}} you're just screwed]]. And keep in mind, these are attacks done by ''[[{{Mook}} normal enemies]]''.
* ''VideoGame/EnchantedArms'' has bonus boss Omega and his Near Death Edge, which, true to its name, instantly chops the HP of anyone hit by it down to 1... and to rub salt in the wound, it also cancels any and all buffs and barriers on the victim, which makes the usual anti-boss tactic of setting up a 90% damage reduction via Raiga's Tiara Crusade more or less worthless. On the flip side, beating Omega allows you to recruit him... and he still has Near Death Edge, which works on [[GameBreaker absolutely anything in the game]]. Yes, including the final boss.
* The spell Abi-Dalzim's Horrid Wilting in ''BaldursGate 2''. On paper, it does 1-8 damage per level of the caster, half on a successful save...but a mage has to be level 15 to know it, meaning an awful lot of damage is being thrown around. This is somewhat unfair when you are a SquishyWizard with less than 40 health and oh sorry just failed your saving throw, time to reload. Especially since unless you were a ''very'' dedicated grinder you are still two levels away from being able to cast it yourself (which is, admittedly, very therapeutic).
* Everything used by Sirius in ''VideoGame/MegaManStarForce 3''. Satellite Blazer, his signature attack, hits every tile of the field and can't be blocked (or dodged for that matter, unless you have Air Shoes). Another favorite move of his is Wing Formation, in which he detaches his wings, which start shooting elemental lasers. He has four wings, so at least one column of the field will ''invariably'' have a double-element attack going on. Again, unblockable and also unavoidable; the only real way to survive this move is to keep getting in columns that don't knock you out of a Noise.
** Apollo Flame in the second and third game has an attack where he drops a miniature sun on Mega Man's side of the field. This attack comes out very quickly, it can't be dodged or blocked (unless you knock him out of it first), and it cracks your panels. It also hits multiple times, so not even a Barrier can save you.
** In linked matches, the Gorgon Eye giga card, which appears in all three games. It does a lot of damage and can pierce through invisibility, and also stuns you. God help you if you're in an electric-type form, in which case it deals quadruple-digit damage.
* The final boss of SkiesOfArcadia brings us the Silver Nightmare attack, where he possesses one of your party members and forces them to use one of their special moves against one of their own allies. It has priority over EVERYTHING, even defensive moves like Justice Shield, and is the only damaging move in the game that has this high a priority. And the possessed party member loses their action for that turn, and quite often you will see him turning Vyse's Pirates' Wrath into a OneHitKill of your SquishyWizard, making that two actions in one turn you just lost, and often more because you get to watch your characters uselessly start using their shield moves. Have fun catching back up with the battle flow!
** As far as ship battles are concerned, there's Bluheim's Blue Winds attack. While technically by itself it does the least damage out of Bluheim's attacks, it causes the ''entire next round'' to be filled with nothing but tiles giving an advantage to Bluheim, which is just as painful as it sounds. The only other attack in the game that does this (Auriga's Hull Ram) is easily avoidable by casting Quika; no such luck for Blue Winds.
* Flash game ''VideoGame/{{Sonny}}'' has Baron Brixius' Tick Tock debuff, which deals damage equal to 10% of the victim's maximum HP... and continues to do this for 10 turns. It also cuts any healing they receive in half, can be cast on multiple characters at once, and can't be removed by status-removing spells. Note that this game has no multi-target healing and no way to revive dead allies. Note also that Baron Brixius would be a MarathonBoss ''without'' this attack. With it, he becomes ThatOneBoss. The only saving grace is he likes to use it on ''himself'' if you last long enough.
** Almost every class has an ability that reverses damage and healing, seemingly for little reason other then to make this one fight easier. In fact, in one portion of the fight, he will begin spamming an ability that heals a third of his health, this is when you stop inverting damage on yourself, and instead concentrating all the love on him.
* The ''VideoGame/EtrianOdyssey'' games are liberally sprinkled with these, as you'd expect from a game this NintendoHard. In general, almost no enemy's basic attack will seriously endanger anyone so long as you have a healer, but even common enemies have abilities such as giving the entire party status effects or doing enough damage to one-or-two shot even the hardiest Protector. The fact that StandardStatusEffects can entirely ''prevent'' these moves from being performed is what keeps them from being {{Useless Useful Spell}}s.
** Shin fron ''The Drowned City'' has a nasty one called 'Demon's Kiss'. It hits various random party members multiple (from two to ''nine'') times, for various amounts of damage, and then heals the boss.
* TricksterOnline brings us Suicide, Banish, and Berserker:
** Suicide is exactly that - a monster that is threatened will explode, taking you with it. Of course, there are some cases where a monster will Suicide while not actually having taken damage already...
** Banish is the bane of Freebie Newbies - If you're inside the banish ring after three seconds, you get instantly teleported to The Hub. Most bosses have this as an anti-Tank measure, and one set of boss trials have an entire room dedicated to not getting hit by Banish (while still getting hit by skills that keep you from moving at all)
** Berserker significantly increases the user's attack power (AP). When a player uses Berserker, they also lose control of their character until the effect ends, and the game selects nearby enemies at random (read: if you use Berserker while in the middle of a crowd, you will do nothing for the first five seconds), it blocks you from using skills, it reduces your health as long as it is active, it lasts for 20 seconds, and you can only start it once every 30 seconds. When a monster uses Berserker, it lasts for 30 seconds, the cooldown is 20 seconds, they can use skills, and they start moving faster. Heaven help you if you come across a monster with both Berserker and Guard Break.
* In ''VideoGame/{{Xenoblade}}'', Jade Face/[[spoiler:Gadolt]]'s Laser Cannon does an absolutely massive amount of ether damage that can easily OHKO party members with lower max HP values, has a huge hit radius that makes it almost guaranteed to hit everybody, and leaves them dazed if they do survive. If you lack the few means of mitigating ether damage effectively and/or aren't of a significantly higher level then him, it can make winning extremely difficult.
* In ''EpicBattleFantasy III'', there's Doomsday, used by [[BossInMooksClothing Cosmic Monolith]]. It deals huge dark-elemental damage to everything on the field - but Cosmic Monolith actually absorbs dark, meaning it can bring your whole party to near death while healing itself. The attack is used every three turns, so if you can't outdamage the healing (taking into account that you also have to recover your health in meantime), you're screwed. An optional fight with two Cosmic Monoliths is actually harder than the FinalBoss.
** ''EpicBattleFantasy IV'' has a few, but one of the worst is used by the Clay Idols (which are otherwise a pushover mook). They have an attack that drains a character's MP. What makes it so nasty is that the amount it drains is completely ridiculous; a single hit can steal roughly 90% of a character's MP total, essentially forcing that character into backup so that their MP can (slowly) regenerate and making them practically useless for the rest of the battle, or else forcing you to run away and restore your MP out of battle. For this reason, it's generally recommended to take out Clay Idols on sight, before even buffing (which you would normally spend most of the first turn doing).
** [[EvilCounterpart Dark Lance]] is generally considered the toughest BonusBoss in ''IV'' due to one attack: Unload. In the player's hands, Unload is nothing special, since it's a physical attack on a mainly magical-attacking character, and it debuffs the user's attack afterwards to prevent it from being even remotely spammable. In the enemy's hands, though? Not only does Dark Lance have a sky-high physical attack, [[MyRulesAreNotYourRules Unload does ''nothing'' to his attack stat]] - he can, and ''will'', use it multiple rounds in a row. And it can hit multiple targets in a single action, [[TheComputerIsACheatingBastard which your version of Unload cannot do.]] Like your version, it hits 6 times, and if Dark Lance has previously buffed his Attack stat (and bear in mind that Dark Lance is ''resistant to dispel''), it can easily [=2HKO=] or even [[OneHitKill OHKO]] with just a single one of those shots.
* ''DarkSouls'' has quite a few. Chaos Witch Quelaag has a devastating area of effect explosion attack; even with high fire resistance, it's likely to stagger you and take off quite a chunk of health. It's telegraphed well in advance[[note]]When Quelaag hugs the spider, ''run''[[/note]], but if you don't get your shield up or get away, you'll get your face blasted off.
** Grappling attacks are unblockable and will usually take off at least three quarters of your health bar every time you're grabbed. Sure, they're telegraphed, but if you're focusing on finishing off another monster or overestimate your dodging ability, it's very easy to get an amateur tracheotomy courtesy of an Infested Ghoul's teeth, or pecked to death by a Crow Demon, or chewed on by the Gaping Dragon, [[TheManyDeathsOfYou or stabbed through the chest by a Wailing Ghost, or smashed into the ground by the Iron Golem]]...
** The Basilisk's attack, which spews a gray cloud of fog that causes curse. Curse is easily the deadliest status ailment in the game, and extremely hard to remove.
* The Procrastination Giant in ''KingdomOfLoathing'' will sometimes counter melee attacks by sneezing on you. This causes the status effect "Cunctitus", which makes you procrastinate. Which is to say, a good 80% of the time you try to make a move in combat, you get the message "You decide to [perform this action] later." This is usually followed by the message, "You lose."
* ''Franchise/TheElderScrolls'':
** ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]'': Greater Bonewalkers have an ''infuriating'' "damage attribute" spell. Note that says "damage" and not "drain." "Drained" attributes will go back to normal once the spell wears off. "Damaged" attributes will stick with you until you heal them with a temple blessing or potion. It's incredibly frustrating to encounter a greater bonewalker halfway through a difficult dungeon only to have him damage your strength attribute so much that you are forced to dump half your inventory (strength determines how much you can carry) in order to flee back to civilization to heal.
** ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'': High level draugr are capable of using the same dragon shouts as you, including the "Disarm" shout. Any weapon you are holding will fly out of your hand and across the room. This alone is annoying, but reasonable. It becomes unreasonable when your weapon occasionally flies into unreachable places, such as ''through the floor or wall.'' If you are on PC, you can use a console command to toggle clipping and go through the wall yourself to retrieve it (if you can find it...) but if you're on a console, tough luck.
* Terracor's curl, the possession attack of the two Shade bosses (which, in addition, can potentially kill any possessed party member so the bosses can recover part of its energy) and Mystic Spider's swallowing attack in ''VideoGame/TheLastStory''.
* PSI Bitchkill in ''VideoGame/TheHalloweenHack'', which can kill your entire party in one hit. Thankfully, it can be reflected.
* Hit-all attacks in ''TheDenpaMen'' are oftentimes devastating, but among the most dangerous is the "Extended its roots" attack utilized by a great number of plant-like enemies. It smashes the entire party for a large amount of Earth-type damage. Even orange, Earth-type Denpa Men and bulky tanks will probably be left with little health after just one, and you can almost assuredly kiss your ability-users goodbye when it hits. The [[BossInMookClothing Hydraplants]] can attack ''twice'' with it in one turn, almost assuredly leading to a TotalPartyKill.
* The Meteor Drive attack in ''LilMonster.'' It's the most powerful attack in the game, and the player cannot obtain it until right before the final boss. But even early-level enemies, and those in the earlier tournaments, can use it. Even when used by the weakest monster in the game, it still does over 100 damage.
* [[spoiler:Demon!]]Trevor in ''VideoGame/ExitFate'' has Annihilation Ray, which does a fixed 5000 damage. That is much more HP than any of your characters can realistically have, and it can't be weakened with Shield.

[[/folder]]

[[folder:Fighting]]
* "Off Waves", Tabuu's instant-kill red ring attack from ''[[VideoGame/SuperSmashBros Super Smash Bros. Brawl]]''. It hits thrice in a row, but once is more than enough if your dodge timing is the tiniest bit off. And that's after it was ''weakened'' by Sonic smashing the wings he extends to perform it. In a cutscene beforehand, he was able to OHKO most of the cast at once. To make matters worse, in Boss mode on Intense if you slip up once on this attack it could send you back to fight all of the other 9 bosses again.
** Master Hand and Crazy Hand have their hand drill attack which is difficult to avoid and capable of dealing up to 90% damage in Brawl. As well, Master Hand's finger walk has been improved in Brawl to have almost no starting lag and move quickly. Woe betide the player that happens to be right next to Master Hand when the attack executes.
** Quite a few characters have what could be described as Skill Gate Attacks as well. Meta Knight's Tornado and Shuttle Loop, Snake's up tilt, Diddy Kong's bananas, Falco's lasers... all are counterable if you know what you're doing, but they're still quite powerful.
** Pit's Angel Ring reflects projectiles, tends to draw enemies inward rather than push them back, and has a massive range which sucks in even opponents melee attacking from behind. Worse, it can continue indefinitely. Very few attacks can put a stop to a player spamming Angel Ring.
** Meta Ridley has an attack where he drops onto the Falcon Flyer, the ''only'' solid ground you have while fighting him. It's a OneHitKO if you don't have the timing required to dodge it.
* Mike Tyson/Mr. Dream in the NES ''PunchOut'' has an uppercut that is a [[OneHitKill one-hit knockdown]]. For the first ninety seconds of the match, he uses it exclusively, so if you're not good at dodging it, you are completely screwed. On the other hand, if you manage to dodge every single one, he'll never use it again (instead substituting an uppercut that looks the same but doesn't knock you down except on rare occasions).
** Several boxers have at least one special attack that can be difficult to dodge or counter at first, such as Bald Bull's Bull Charge (also an instant-knockdown attack), Super Macho Man's Super Spin Punch attack (which is another instant-knockdown attack), Mr. Sandman's Dreamland Express, or King Hippo's Twin Smash Combo.
* Devil's/Angels laser beam in ''VideoGame/{{Tekken}} 2'', also Jinpachi's fireball attack. Both can be dodged if you can see it coming, though; Jinpachi's fireball can even be low parried(!).
** Jinpachi's "stun palm." He creates a wave that stuns the character for a minimum of 3 seconds. It has priority over every single other action in the game, coming out as fast as a jab. If you're jumping or even just lying on the floor after a knockdown, it will reset you into a standing stunned position. It can only be blocked low with proper timing. Simply put, it makes any match against him purely luck based, as you can only win if he takes pity on you and decides not to use it.
** Unknown in ''Tekken Tag Tournament 2'' has the Mizuchi Claw move. It involves her summoning a portal from the ground, which traps you in place and causes a large hand to appear from the ground and splat you, [[HPToOne forcing you out of the arena with a pixel of your health]] and your partner in. On Solo characters, it shaves off 50% health; this can be much worse depending on your skill level because she has an inclination to use this move over and over, which means certain death if you can't sidestep. That's not even taking into account her [[SNKBoss batshit AI and plethora of other cheap moves]].
* I-No's Megalomania in ''VideoGame/GuiltyGear XX'' and follow-ups. If any part of it hits, the whole thing hits. It comes in three patterns, and she can freely Force Roman Cancel between them to throw you off.
** However, even Megalomania (which was originally a boss-only move but was eventually made playable due to being fairly easy to dodge with the right timing) must bow to Boss-Dizzy's Wings of Light. Like Megalomania, Wings of Light consume the burst gauge instead of the Overdrive gauge, making it available from the start. The difference? Wings of Light has three different effects depending on the distance between you and Dizzy. If you are on the opposite side of the screen (max distance) a PillarOfLight falls on you, either dealing 3/4th of your health if unblocked, or 1/4th if blocked with Barrier. The second, if you are at an average distance, consist of a giant laser beam which turns around on the screen with Dizzy at it's center. Despite appearance, it is ''just'' fast enough to be completely undodgeable, and it is either an instant-kill (if unblocked) or deals roughly 1/3-1/2 of your health if perfect blocked. The final effect, if you are close to Dizzy (like, say, you were attacking her when it started, or she dashed into you to put you into a corner), you die. Instantly.
** Also, ''Accent Core'' gives us Boss Order Sol's Flame Distortion. It's basically Sol's Dragon Install except on this one the boosts are so humongous that he can close in from full screen in no time to counter your moves, and he also has infinite charge gauge, as well as auto-tension gain. His moves become so fast and strong that he can take off over 70% of your life in a single attack, because he's fond of his supers' invincibility frames. If he goes for Dragon Install: Sakkai (which he can easily combo into), expect it to kill you.
* Three words: [[Franchise/StreetFighter Shun Goku Satsu.]] Final Bison from ''VideoGame/StreetFighterAlpha 3'' also has a super fast, extremely damaging variant on his usual Psycho Crusher called Final Psycho Crusher.
** Luckily, there are two tell-tale signs that he's about to use the FPC (in the [=PS1=] port, at least): Once his meter is filled, if he either teleports to one side of the screen or uses his diving attack out of the blue, it's coming next, no questions asked.
** Note must go to Shin Akuma's version of the SGS in ''Super VideoGame/StreetFighterIV'' (particularly its upgraded Wrath of the Raging Demon Ultra), which is a zero-frame grab (i.e. if you're right next to Akuma, you're a goner) with high-priority over nearly everything (including other Ultras!), comes out incredibly fast compared to past incarnations and the playable Akuma's version, covers the entire screen, and uses the Ashura Senku for the slide itself, allowing Akuma to ''phase through'' moves that would normally cancel the SGS.
** For a while the ''Street Fighter'' series was in love with these. As mentioned above, ''[=SFA3=]'' gave Bison a full-screen Psycho Crusher that would probably end up losing the match for you if you didn't block it. Gill from ''VideoGame/StreetFighterIII'' had both a full screen nuke AND a self resurrection; fortunately Gill's attacks were interruptible, if you got to him in time.
** The Hadoken from ''VideoGame/StreetFighterII'' was close. On harder difficulties, Ryu would happily fire a constant stream to chip you to death, and if you time the jumps poorly, he'd take you out of the air with a Shoryuken when you got close enough.
** Balrog from ''Street Fighter II'' had two of these in his dashing punches. If he spammed them for long enough he could kill you through block damage alone with you having no defense unless you were playing as Ryu or Ken and your dragon punch timing was impeccable.
** Zangief's Siberian Blizzard Ultra in ''SSFIV''. Like Akuma above, the move out-prioritizes just about anything besides another Siberian Blizzard.
* ''VideoGame/TheKingOfFighters''' bosses all have at least one of these. Rugal has Genocide Cutter and Gigantic Pressure, Goenitz has his spammable Yonokaze projectile, and Orochi has his screen filler super.
** Magaki in ''XI'' gives us his fireballs. At times they fill the screen, and the blue ones are one-third of your life if they hit. Apparently someone confused ''The King of Fighters'' with a BulletHell.
** Surely we can't just leave Rugal's Genocide Cutter as a passing mention. The move, in ''[='94=]'' anyway, has ABSOLUTE INFINITE PRIORITY and does the highest damage of any move in the game. God help you if [[OneHitKill Rugal has a full bar of meter]]. And on the subject of this series, Igniz's qcf+P whip attack is an infinite. It can be done eternally as needed to empty your lifebar, and what's worse is he can also do it to set up for Brutal God Project, his very fast instant kill. In fact, he can do this without setting it up and you probably won't be fast enough to block it.
** Krizalid, the final boss of ''[='99=]'' and essentially the "Rugal" of the NESTS Chronicles, has Typhoon Rage, which might possibly be in a league of its own. Not only does the damn thing have a large hitbox, but, much like Genocide Cutter, the move has priority over virtually ''everything'', does ridiculous damage even on block, can juggle easily, and fills up Krizalid's meter absurdly fast (doubly so if you decide to guard against it). It's telling that, in ''[[DreamMatchGame 2002]]: [[UpdatedRerelease Unlimited Match]]'', Typhoon Rage makes Krizalid a bigger threat than every other boss in the game--''in a game filled to the brim with {{SNK Boss}}es, '''including Omega Rugal and Igniz'''''--barring [[PurposelyOverpowered Nightmare Geese]]. That's not even getting into his bag of other dirty tricks. One move alone, and he's already the second most broken character in the game.
* Geese Howard's counterthrow in ''VideoGame/FatalFury''. If you try to hit him with a direct attack, he can throw you. This includes jumping too close to him. There's also his Raging Storm in later games, which is often used ''the first frame'' of your forward jump.
* The third ''[[VideoGame/SoulSeries Soulcalibur]]'' game's [[BonusBoss Night]] [[TrueFinalBoss Terror]] has an attack that has a blue sphere erupt around him. If you try to cancel this attack, it just becomes stronger and unavoidable. Also, he has one that [[FrickinLaserBeams fires barely-avoidable lasers at you.]] If he puts his "earthquake" move before that, you're screwed.
** Think you've taken down Colossus? Better move, because otherwise, [[KaizoTrap he'll fall on top of you, killing you]] '''[[TheComputerIsACheatingBastard before the match actually ends.]]'''
** Any S-rank ability in ''Soulcalibur IV'' could qualify, but the worst is Auto Impact S, especially when combined with Impact Edge, Impact Heal, or both. It allows the enemy to randomly get Guard Impacts (thereby interrupting your attack and making you vulnerable to a counterattack), even if they do nothing that would merit one. At S-rank, it happens ''a lot''. Impact Edge hurts you when you get Impacted, and Impact Heal restores health on a successful Guard Impact. Combine them for maximum frustration. It's also worth noting that [[TheComputerIsACheatingBastard only the computer can have S-ranked abilities.]]
** Nightmare's Critical Edge is also ThatOneAttack in the sequel, ''Soulcalibur V''. Unlike many of the Critical Edge attacks, it can outright counter an incoming move instead of interrupting it, so you're going to be eating it unless you were blocking before he released it. Also, unlike most Critical Edge moves, which tend to do 25% or so of the health bar, Nightmare can devour ''75% of your Health'' with this one attack and go on to use his multiple options for punishing downed characters.
*** Addendum: Dark Reconquista only deals that obscene an amount of damage ''if'' the player lets Nightmare remain idle while gathering power (which takes about a full second's worth of time) instead of activating the move's built-in Guard Impact (which can't be triggered by throws or {{unblockable|Attack}}s). If it's a counter and/or a Clean Hit, the Critical Edge stings more on top of that. Potentially, the move can beat out even Algol's alternate CE that requires [[LimitBreak both bars of meter]] for the title of strongest attack in the game. Triggering the move off of the counter (usually) does significantly less. One's knowledge of how to dissect Nightmare [[AwesomeButImpractical makes all the difference in how effective the attack is]].
** [[spoiler:Elysium]]'s Critical Edge as well. It's pretty much a machine gun that fires invisible bullets. And if it hits you while you're on the floor, it causes you to levitate so you can be hit by [[spoiler:her]] other attacks easier.
* ''VideoGame/DeadOrAlive 4''. Alpha-152. Okay, got her... GOT HER... NO! That stupid attack where she grabs you, knocks you down, then smacks you across the face a few times which removes 70% or so of your health! Resist... urge... to... toss... 360... out... window.
** In ''Dead or Alive 2'', Tengu can use a wind attack. It can knock you over, do a large amount of damage, and worst of all, is the only ranged attack in the game.
* [[VideoGame/BlazBlue Ragna the Bloodedge]] has a AwesomeButImpractical attack called "Devoured by Darkness" which is unblockable and damaging, but balanced by a requiring a lot of Ragna's super meter, having to go into his DeadlyUpgrade Blood Kain state to use it, losing said SuperMode after an (attempted) use and being a close-range grab. Any semblance of balance goes out the window for his TrueFinalBoss form ''Unlimited Ragna'', who can use Devoured by Darkness nearly at-will to blow away 70% of your health and massively heal himself. Also, it doesn't remove Unlimited Ragna's Blood Kain.
** We cannot mention ''[=BlazBlue=]'' without mentioning [[SkillGateCharacters ICECARZ, Chain Revolver]], [[StormOfBlades SWORDSPAM]] and [[BeeBeeGun BEEZ]].
** No listing of 1-hit and 2-hit kills can be complete without the Genesic Emerald Tager Buster. This about sums it up:
---> '''Tager''': "[[CallingYourAttacks Any last words?]] [[PunctuatedForEmphasis This is going to be! Your end!]]"
---> '''Announcer''': "'''DISTORTION FINISH!'''"
** [[SNKBoss Hazama's]] Serpent's Infernal Rapture. The damage isn't that insane -- the problem is that he ''will'' use it on you the ''first frame'' you are open, and it knocks you flying into the air, totally disrupting your combo and setting him up for one. He can, and will, even pick you off with it between your attacks.
*** And just when you thought it couldn't get any worse, ''[[VideoGame/BlazBlueChronophantasma Chronophantasma]]'' gives [[SNKBoss Hazama's Unlimited form]] an upgraded version of the move with tracking properties. ''[[FlashStep From anywhere on the screen.]]''
* ''VideoGame/MagicalGirlLyricalNanohaAsPortable: The Battle of Aces'' has a few of these. Hayate's - and by extension [[EvilTwin Material-D's]] - basic attack is a [[BeamSpam spammable energy-ball thing]] that, once you're in range, can pretty much lock down the enemy until you run out of mana. Vita's Swallow Flier with its five homing energy balls is hard for most to swat out of the air outright and she can whore it much more than one can usually dash away from it.
* ''VideoGame/MarvelVsCapcom3'' has several:
** One of the biggest ones is [[ComicBook/{{X-Men}} Phoenix's]] [[SuperpoweredEvilSide "Dark Phoenix"]] mode, which restores her to full health with a buttload of stronger, [[BeamSpam projectile-launching]] attacks and a weakness (her [[CastFromHitPoints constantly-degenerating health bar]]) that can be compensated for with relative ease. The uptick is that it's a ''Level 5'' Super, so you'll know it's coming if your opponent never touches their Super meter (and if you can kill Phoenix before the meter reaches Level 5, you'll never see it).
** [[HumongousMecha Sentinel's]] "Strong" regular attack is a plasma beam the length of the screen. The easiest projectile to use in the game, and therefore the most commonly spammed.
** [[VideoGame/StreetFighterII Akuma]] is ''made'' of this. Most egregious is the [[HurricaneKick Zankukyaku]], a ramped up version of Ryu's Tatsumaki Senpuukyaku. Note that while both attacks hit multiple times, Akuma's does more damage, which along with the [[EnergyBall Gohadouken]], [[{{Shoryuken}} Goshoryuken]], and the returning [[NothingIsScarier Shun Goku Satsu]], combine to earn him the reputation as one of the most feared and hated opponents in the game.
** Galactus, pictured above, has two attacks that qualify.
*** The pictured attack above has him firing FrickingLaserBeams from his eyes and fingers, slowly spreading them out and up the screen. It is literally unavoidable unless you're playing a flying character (and then you gotta avoid when he looks up). It will kill your character if you get hit by it, or nearly kill you from full health if you're playing a tougher character like Thor. If you block it, you can expect about 3/4 of your health taken away. Instead of using the X-Factor to avoid damage altogether, the recommended way to survive is to spam Advanced Guard, which will only take a very small fraction of your life. You'll still take damage, but at least you can use it more than once.
*** He also charges up his Planet Destroyer as a DesperationAttack. It takes a long time to charge up, and you can flinch him out of it if you do enough damage while attacking, but if it goes off, it's a guaranteed OneHitKill to your current fighter. You don't want to have the rest of your team assisting on screen when it goes off.
** No list of irritatingly potent attacks from ''[=MvC3=]'' is complete without SelfDemonstrating/{{Doctor Doom}}'s Hidden Missiles assist. When called, Doom will fire missiles he [[CrazyPrepared likely put there some time ago]]. The annoying part is that the missiles fire upwards, arc down, and then ''home in on their target''. Oh, what's that, you just started a combo you spent months practicing? Nope, you got hit by a stray missile, then the rest hit you and your opponent has just got you in their own combo, your character is going down.
* Gantenbain's warping kick in ''Manga/{{Bleach}}: Heat The Soul 6''. He warps into melee range and kicks you in the face. This attack has very little warning and is extremely difficult to dodge. Some of Szayel's heavy attacks are similar; he spawns a GiantMook to attack you, except those moves have even less warning, and one of them can hit twice.
* ''VideoGame/ArcanaHeart 3''[='s=] FinalBoss Ragnarok has an attack that fills most of the screen with unblockable pink lasers. Hope you've mastered homing attacks to dodge it. Worse, it also gives him nearly a full second of total invulnerability in a TimeLimitBoss fight.
* The FinalBoss of ''VideoGame/TatsunokoVsCapcom'', [[spoiler:[[VideoGame/{{Okami}} Yami]]]], has an attack that he uses during his first form where he lets out a red forcefield. It breaks guards ''and'' steals a special meter from you, and it's damn near unavoidable if he's in the center of the screen.
* One cannot bring up Akuma or the ''[[VideoGame/CapcomVsWhatever Vs.]]'' series without mention of the sheer nightmare that is the [[DeathFromAbove Misogi]] from ''[[VideoGame/CapcomVsSNK2MarkOfTheMillennium Capcom vs. SNK 2]]''. Available only to [[OriginalGeneration that game's version of Shin Akuma]] (fueled by the [[VideoGame/TheKingOfFighters Orochi power]]), Misogi is an instantaneous cross-up from above that ''homes in on the player at absurd speeds''. If it connects (and it probably will), [[http://www.youtube.com/watch?v=ZDFTNRD3rhU the unlucky party]] [[OneHitKill is as good as dead]]. If they do manage to block, much like Final Bison's Final Psycho Crusher or Gill's Seraphic Wing, you're ''still'' screwed due to the litigious amount of chip damage it deals. Worse still, the move can't be [[VideoGame/StreetFighterIII Parried]] or [[VideoGame/FatalFury Just Defended]] in ''[=CvS2=]'', and for its encore appearance in ''[[VideoGame/SNKVsCapcomSVCChaos SVC Chaos]]'', ''[[UnblockableAttack it's unblockable]]'' (because apparently the super's ''other'' properties weren't bad enough). You can avoid it with one of the scant few teleport specials or [[http://www.youtube.com/watch?v=T2ghZxB3oLY (attempt to) counter it if you're courageous,]] but if not, all you can do is cross your fingers and hope you timed your roll/dodge properly. Even worse, Shin Akuma is ''still'' considered the '''easier''' of the two {{True Final Boss}}es. This is because the alternative is God Rugal (Rugal Bernstein after draining Akuma's power into himself). The Genocide Cutter is ''even stronger now''.
* Dr. Eggman in ''VideoGame/SonicBattle'' has a TakingYouWithMe type move that is used each time his health bar is depleted. When he says "It can't be!" get ready to lose a life because it is very hard to dodge -- and impossible to block -- the massive explosion that comes after that.
[[/folder]]

[[folder:Shooter]]
* ''VideoGame/{{Gradius}} III'''s lava stage boss explodes into pieces upon dying. Pieces that will ''[[TakingYouWithMe kill you]]'' if they collide with you.
* ''VideoGame/InTheHunt's'' FinalBoss has ''two'' phases where it [[ThatOneAttack only uses ONE attack]]. Unfortunately, said attack resembles something from a BulletHell: it generates a minefield of indestructible red mines that absorb your shots. Made worse is the fact that you have a large collision box.
* ''The HouseOfTheDead III'' has The Fool's final attack pattern, in which he jumps from one side of the cage to your side, swiping you in the process. To prevent his swipe from hitting you, you must hit his remaining claw 6 times in what little time you have. Now, your gun has 6 shells. If you miss even ONE of those shots, you ''will'' fail because it takes too much time to reload. Oh, and did you bring a second player with you? Well, now you must hit him '''12''' times, or 6 shots from each player. Which means if the other player is [[{{Noob}} not very good]], or is [[{{Scrub}} some dumb kid who is fooling around]], you are royally fucked. ''[[FakeDifficulty Even if all of your shots are spot-on.]]''
** The Magician from the first and second games switches from fireballs to hard to counter melee attacks in the second and fourth phases of the battle. It's hard enough to shoot his weak spots, but it's worse when he attacks so quickly.
* From ''VideoGame/{{Hellsinker}}'' we have Perpetual Calendars "Lunatic Phantom". It's a blue flame that flies around the stage in a semi-random pattern at high speed. It also cannot be suppressed meaning that if it catches up to you, you will either lose a life or burn an auto reject.
** In the Shrine of Farewell we have Million Lives' "Innocent Clockwork", which spews out cogs that ''block non-piercing attacks.''
* The FinalBoss of ''VideoGame/ChimeraBeast'' has a move where it uses its horns to fire electric balls offscreen. Seconds later, the screen gets filled with damaging, hard-to-avoid [[PillarOfLight pillars of lightning]], which strikes a number of times depending on how many electric balls got fired off. If all the boss' horns are still alive, it becomes extremely hard to avoid.
* The Edged Weapons Experts in ''VideoGame/SpecOpsTheLine'' sprint towards the player (often haphazardly running between cover elements) with very little warning to come in for a OneHitKill stab attack sending the player back to the last checkpoint so they can do it all again.
[[/folder]]

[[folder:Rhythm]]
Rhythm games in general have fixed "charts", so you know when ThatOneAttack is coming, and have time to say ThisIsGonnaSuck before it comes.
* [[VideoGame/DanceDanceRevolution Max300 and Maxx Unlimited]] both have crazy sections after the big pause in the middle. In fact, DDR has a metric, called Voltage, which basically just measures how difficult ThatOneAttack is for the selected song.
** Battle mode of the PS2 games can also throw modifiers at you ''in the middle of a song''. One popular tactic for the computer to wield is putting 2 of the 4 arrows on Sudden, or putting every other beat on double speed. These are MUCH harder to read than they sound.
** Healing-D-Vision has a 5-second run of 12th notes at 360 BPM. Have fun trying to Triple-A the song. Oh, and the run goes LDRDLDRD; normally these are handled by using the same foot for the L and R panels ("cross-overs"), but at this speed, that's a write-off; instead, the only hope is to exploit the design of the pad and ''brush'' the panels using the heel and toe from the same foot on different panels. Fun.
** The streams in Horatio on Challenge, mainly because of the absurd amounts of FakeDifficulty in it. Especially egregious in the [=PS2=] version, where the shock arrows are on EVERY GODDAMN BEAT OF THE STREAM.
** Valkyrie Dimension has a slowdown near the end...which then becomes a [[DifficultySpike massive stream at 400 BPM]]. Is it any wonder that it took months for someone to clear it?
*** The Challenge chart throws down another nearly impossible stream; this one goes at '''480 BPM'''. To put this into perspective, Determinator below has 14.7 notes per second; this is 16. It doesn't help that, while InTheGroove has a lot of really tough charts to get one used to runs like the one Determinator, DDR has very very few such runs, so when one does come along, it's an absurd DifficultySpike that can only be completed by people who have played other games.
** [[BreatherBoss Sakura]], even though it's widely acknowledged as the easiest 10 in the series, still has one, in the form of a slowdown to about 20 BPM. This is very, ''very'' slow and makes the incoming notes very hard to hit. And there's a second one at the end of the song, too!
* [[InTheGroove Determinator]] is a fairly difficult but manageable song. Except for one little part that makes you move around the pad at the rate of 14.7 stomps per second. If you're not sure how fast that is, it is very, very fast. (Example [[http://www.youtube.com/watch?v=BSOHpSZcHoA#t=01m05s here]]; the fast part starts at 1:16.)
* [[RockBand Caprici Di Diablo's]] third guitar solo is even faster than the rest of the song. Dozens of other songs in RockBand and GuitarHero have their own ThatOneAttack, but many can be faked through using star power. Unless it's at the start, like in Foreplay\Long Time, or a long "attack", like the drumming climax of most TheWho songs, or there are two such attacks, like [[Music/TheRollingStones Green Grass and High Tides]] on guitar (like in many RPG examples, except you're ''guaranteed'' to get hit with it twice in a row).
** Green Grass and High Tides's snake patterns are actually easy to full-combo on a Rock Band guitar if you use a technique that flat-out should not work: [[ViolationOfCommonSense holding down the middle fret for the entire duration and pulling off from the outside frets to the middle fret, using the shredboard all the way.]] I'll repeat that once again: you PULL OFF FROM A LOWER FRET TO A HIGHER FRET. This only works during solos, and only works on a Rock Band guitar.
** Playing Free Bird in Guitar Hero II, one of the loading screens is "you're looking for "Gtr solo i" in Practice Mode."
** Guitar Hero III had the infamous battle mode. You're in trouble if the boss hits you with Lefty mode, which mirrors the display of the notes. Lefties don't get off easy, they get hit with Righty mode instead.
*** For those who play on lower difficulties, Difficulty Up is a nasty one. If you get hit with it during one of the harder songs- especially the solo of "One" by Metallica- you will die ''fast''.
** The zig-zagging in Green Grass and High Tides is nothing compared to Satch Boogie on GHWT and RB [as DLC]. To borrow Guitar Hero 2's loading screen joke for Freebird, "You're looking for "Surf Solo" or "Guitar Solo 2A" in Practice Mode."
** While we can't mention every DLC that belongs here, the song ''According to You'' is very, very this on guitar.
*** ''Can't Be Tamed'' is a pain on guitar as well, don't get fooled by the fact that it's a Miley Cyrus song, it's on the "Nightmare" tier for a reason. It's a particularly egregious example, because the song itself has no actual guitar parts(Harmonix charted the solo just for the game) and it starts off really easy, so you're most likely not going to expect to get nailed with a nasty solo section that gives "Tornado Of Souls" a run for it's money.
** Walk up to any drummer that has seen the drums-expert chart to all of CoheedAndCambria's DLC and start singing "Cold as winter's [[ThatOneBoss guns of summer]] point and watch them run".
** We cannot talk about this without mentioning the guitar solo from "Constant Motion". The first half is fairly easy. Then you get hit with the practically random strings of notes followed by a bunch of 23-note-per-second triplets. Eagh.
** One of many keyboard charts with this is Roundabout by Yes. The whole thing is hard, but where does the shit really hit the fan? Why, in SubduedSection of course!
* It is possible for BMS charts (and their derivatives) to have some degree of randomness, meaning that a cruel charter can have an easy section at one point on one run and then on another run have the same section be replaced with a really difficult section, [[LuckBasedMission and which one gets used being determined by a random number generator]].
** One rather popular song in particular, Jack-The-Ripper, has two: the [[http://youtu.be/2LjRxSR9FWs?t=1m2s stream going to the guitar]] and [[http://youtu.be/2LjRxSR9FWs?t=1m42s this 30-second hell.]]
* Many of the bits from ''BitTrip'' qualify, but some of the worst are the bits that change back and forth from black to white from ''Void''. If you don't get the timing down quickly, you will lose points both from missing black bits and collecting white bits, and you will fail ridiculously fast.
* ''BeatmaniaIIDX'' uses a special LifeMeter system in which you must have at least 80% of your life intact when the song finishes. So how do some charts get FakeDifficulty? By having ridiculous patterns at the very end after a only moderately hard or an outright breather section, often forcing the gauge down to a dreaded 78%. Charts with such BS endings lead to many cases of [[http://www.youtube.com/watch?v=HY1FCqU5VVg#t=1m25s getting the highest grade on the song and STILL failing it]].
* ''{{DJMAX}} Technika'': [[http://www.youtube.com/watch?v=NiFHl3snp04#t=1m35s Son of Sun (SP)'s]] end segment. GO GO GO GO GO--'''GAME OVER.''' Some people have even made montages of fellow players failing the song.
** Also on SP difficulty: Your Own [[strike:Miracle]] [[http://www.youtube.com/watch?v=_kxdApN01Nw#t=1m7s Bullshit]]. Go on (Go on) / Pick those beautiful feet up off the--'''GAME OVER.'''
** [[http://www.youtube.com/watch?v=OWDBIfrTTZE#t=1m40s A.I. (TP)'s]] ending. It say something about how awkward the ending is when ''people who have cleared the Challenger Set'' still "spam" that segment. By the way, notice that all of the examples thus far involve [[ScrappyMechanic gratuitous repeat notes]]?
* ''OsuTatakaeOuendan'' and ''EliteBeatAgents'' have their fair share of examples: the last section of "Shanghai Honey" on Insane (notes spread out all over the place and designed to mess up those who assumed Insane was just a mirrored Hard chart), "Jumpin' Jack Flash" and its infamous third verse (ridiculous clusters of notes with spinners interspersed), and, of course, the last 14 notes of "Countdown" (be prepared to go from full-health to fail in 2 seconds!).
** If not the third verse of Jumpin' Jack Flash, the fourth and final verse is. A brutal segment where the game throws every beat trick it can think of, along with a weakened life bar (From the third section) that is dropping faster than ever. Miss any one of the notes haemorrhaged to you on Hard Rock and you are DEAD. Failing here is downright heartbreaking.
** The Anthem in EBA has the final spinner for people trying to S Rank the song. The thing is '''Damn near impossible'' without spinning as fast as humanly possible.
* From ''SpaceChannel5'':
** When it reverses your controls.
** In the beginning of level 2 of part 1? Up down up down up down up down updown.
*** And later, rightleftchu, leftleftrightrightchuchu. Notice that there are no spaces - they come at you ''THAT'' fast.
** One part of Part 2 gives you ''twenty two'' step commands to repeat.
** [[KaizoTrap Up!]]
*** The last sequence for the final boss battle in both games are a KaizoTrap; failure to complete the last "chu chu chu" sequence as the boss is about to be defeated will cause an instant Game Over and you have to restart the stage ''all over again''.
** The second section of Report 2 Bonus in the first game. [[OverlyLongGag "Up down up down up down up down up down up down up down..."]] It's a solid thirty seconds or so of up-down finishing with a typical 3-Chu. Then after that, you get to do it again with Right left. Listening to the music helps you keep your place, but the sheer length of the commands can still throw you off it you aren't paying attention.
* [[VideoGame/DJHero Push It vs. I Want Your Soul]] has a nasty stream of 16th taps all on the same track. And it's one of the faster mixes. Planet Rock vs. Busy Child also does the same thing, but it's shorter and makes up for it by having you ''hold a note at the same time''.
** Pretty much any time that pattern happens.
** On Expert, [[http://www.youtube.com/watch?v=MDfJYGY54Sw Move For Me]] has a BRUTAL section with about 160 actions in 15 seconds (starts around 2:21 in the video).
* The final song in ''VideoGame/HatsuneMikuProjectDiva Second'' ("The Singing Passion of Hatsune Miku"). At first, you get a long stream of constant Os that feels like That One Attack, seeing as you're even greeted by an easier section directly after. Five seconds later, the game gets serious and you have to hit O eight times per second, doing it too fast gets you killed. This is still the easy part. And then when you finally feel like it's over... Well... [[http://www.youtube.com/watch?v=E3DpAT3tGsY&feature=player_detailpage#t=110s Words really can't describe this. this is something you have to see.]] As pretty much standard, ''this is harder than it looks''.
** The first game has the similarly difficult "Disappearance of Hatsune Miku", which was clearly the predecessor for the way Singing Passion is played in the sequel.
* ''[=O2Jam=]'' has the Identity series on Hard difficulty. All three songs' Hard charts have a section consisting of 1/16th notes forming a word in ''hangul'' (Korean script). There is no verified human attempt at clearing that particular pattern without any combo breaks.
[[/folder]]

[[folder:Action]]
* Rank 2 in ''NoMoreHeroes'' has an attack that instantly kills you. What does she do? She drops to the floor crying. If you hit her, or even get close to her, she instantly beats you to death. At no point is it hinted that this will kill you, and if you play the game without knowledge of this, YOU WILL DIE. To make matters worse, she can sometimes do this in mid combo. Even more aggravating is that sometimes she actually ''is'' crying ([[spoiler:she only attacks if she left one hand on the bat]]), so you can get thrown off easily if you aren't watching.
** Rank 4 of the first game, the boss has a near undodgeable spinning attack that takes a large chunk of health and can not be blocked.
** Mimmy, in ''Desperate Struggle'', has the spinning attack. "YIPEE!"SLAP!SLAP!SLAP!SLAP!SLAP!SLAP!SLAP!SLAP!SLAP!
** Rank 7 in ''Desperate Struggle'' can summon a dragon made of energy. This dragon will follow you ''very'' closely, and Travis can't dodge fast enough to escape it. And ''Rank 7 will still attack freely as it's chasing you!'' The dragon [[spoiler:can be blocked, though it eats your battery like candy; it also has a tell: If the sky is dark it's still chasing you, if the sky clears it's gone.]]
** Rank 1's second form is even worse. About halfway through the battle, he'll start teleporting around, attacking three times in rapid succession. In a game where you dodge primarily by rolling, this attack comes ''faster than you can roll.'' If you manage to get him down to 1/4th HP, he'll start spamming that attack and a series of three whirlwind punches that are equally difficult (read: impossible) to dodge. The worst part? Both attacks knock you back a considerable distance, and can ''send you out of the arena, one-hit-killing you.'' That said, the teleport punch is avoidable provided you have hair-trigger reflexes and know that the second punch will almost always miss if you dodge the first, leaving you free to dodge the third. The tornado punch? Nnnnot so much.
* The suicide attack by the Egg Viper in ''VideoGame/SonicAdventure'', if only because of the horrid camera angle. Some of the Sonic Rush battles (and the Sky Canyon boss in ''SonicAdvance 2'') have instant death attacks, or attacks which are nearly impossible to avoid consistently.
** The ''VideoGame/{{Sonic Rush|Series}}'' ones are very well-telegraphed, though. Probably the only hard one to see coming is the one where Eggman (or Nega) rams his giant robot's shoulder spikes into the stage at the end of said battle, mostly because you've never seen it before. The button-mashing on the Sonic vs. Blaze battle would be hard to see coming as well if it weren't for the mini-cutscene and the fact that one boss earlier used an easier version of the button-mashing gimmick.
* The charging tackle Meta Ridley in ''MetroidPrime'' does when he's on the ground. It's not too hard to avoid at first, but later on, especially in Hard mode, he seems to be able to guess where you'll be. Cue frustration. In fact, physical attacks in general are pretty annoying in ''{{Metroid}} Prime'' as you may get cornered.
** The whole reason the Boost Guardian in ''Metroid Prime 2: Echoes'' is ThatOneBoss is precisely because of ThatOneAttack. He's a ''piece of cake'' otherwise, even on Hard mode.
* JetForceGemini's second fight with Mizar has the infamous "electric jump rope". It's probably 80% of the reason the Mizar rematch is [[ThatOneBoss hair-pullingly tough to fight.]]
* In ''VideoGame/{{Prototype}}'', [[spoiler: the Supreme Hunter]] can use the same tendril barrage you can, and it inflicts a terrifying amount of damage. Furthermore, depending on how chaotic the fight is, noticing the move being prepared can be extremely difficult, and there's no getting out of the way once it's been unleashed on you unless you were on or very near the edge of its effective radius and moving away when it's fired.
* [[Franchise/{{Castlevania}} Dracula]] in ''VideoGame/IWannaBeTheGuy'' is already a bone-crackingly difficult LuckBasedMission, but he has one attack that [[UpToEleven (even by ''IWBTG'' standards)]] seems programmed to screw you over. He shoots a single, homing Delicious Fruit at you. It's too slow to accidentally fly off-screen, hangs around long enough that you're gonna have to dodge it, and if he follows up with his fireball attack (which floods the floor with, well, fire), or those purple things are flying around, you're screwed.
* In ''[[VideoGame/CastlevaniaOrderOfEcclesia Castlevania: Order of Ecclessia]]'', Dracula throws long streams of bats that bypass MercyInvincibility and will shred your HP down to nothing in seconds if you get caught off guard. If you can avoid that, then it'll be the bloody soul steals out of nowhere, which do a lot to you and give him a bit more health back. ''[[VideoGame/CastlevaniaPortraitOfRuin Portrait of Ruin]]''[='s=] bosses normally have a single attack that is much more difficult to work against than the others too.
** Being the hardest of all old-school ''Castlevania'' games, ''[[VideoGame/CastlevaniaIIIDraculasCurse Dracula's Curse]]'' gives Dracula's first form (of ''three'') a fire spell that summons two spires on each side of your character and a larger spire directly targeting you, in which you have barely a microsecond to avoid. Sometimes the side-spires will spawn directly next to you, in which case you are '''''fucked''''' ([[http://cinemassacre.com/2009/10/21/castlevania-part-2/ see for yourself]] in WebVideo/TheAngryVideoGameNerd's review).
*** Note the flame pillars will appear closer to you based on the distance between you and Dracula. So it could be very well a SchmuckBait.
** Death is the series' go-to guy for ThatOneBoss fights, so it stands to reason that he'll usually have one of these in his arsenal. Aside from the constantly spawning mini-scythes, the move that really takes the cake are the giant skulls in ''[[VideoGame/CastlevaniaChroniclesOfSorrow Dawn of Sorrow]]'', which deal insane amounts of damage, take up most of the screen, and [[KaizoTrap are the only projectiles in the game that don't disappear when Death is beaten.]]
** He also has one in ''[[VideoGame/CastlevaniaChroniclesOfSorrow Aria of Sorrow]]'', where he rolls his scythe along the floor, walls and ceiling at high speeds. It too deals huge amounts of damage, and depending on where the player is standing in the room, it's anywhere from easy to nigh-impossible to dodge.
* In ''VideoGame/MegaManX5'', the fight with Zero has him throwing nearly-full-screen {{Sword Beam}}s that you have to dodge in sequence. Capcom acknowledged this by making this attack Zero's Level 3 Hyper Combo in ''VideoGame/MarvelVsCapcom3''.
** God help you if you're fighting ''[[SuperpoweredEvilSide Maverick]]'' Zero. His variation of that attack inflicts instant death or close to it, and if you should leave him at low health for too long, he will back into a corner and fire that attack continuously until one of you is dead. Fun.
** Bamboo Pandamonium's desperation attack in ''X8''. Like every boss with such a move, he telegraphs it, but that won't help you; the punch he throws is sudden, fast, its hitbox takes up over half the screen, and deals an ''obscene'' amount of damage. On Normal and Hard, if you've not bought enough life gauge upgrades, you dodge it or you lose a character.
*** The attack is specifically designed to one-shot Ride Armour, which makes the fight much easier if you managed to maneuver it to his arena, as it allows you to [[GameBreaker continuously pummel him while taking zero damage]], until the Armour is inevitably destroyed. Better be confident in your reflexes if you're not in Ride Armour when that attack begins. Oh, and there is no Ride Armour when you fight him again in the BossRush. Hope you've got full Life Tanks!
** [[spoiler:Lumine]]'s first form uses the desperation attacks of the 8 Reploid bosses, including the one mentioned above. However, there are two attacks that he modified; Avalanche Yeti's attack, which causes gigantic snowflakes that freeze you on contact to rain down, lasts a ''lot'' longer, and [[spoiler:Lumine]] can still blast you with other attacks while it's in effect. And then Burn Rooster's attack, which engulfs the walls in flames, ''never wears off''. After it hits the field, you can no longer wall-jump.
*** [[OneWingedAngel His second form...]] When his health dips low, he uses an attack that makes [[RocksFallEveryoneDies darkness start enveloping the screen]] while he [[TeleportSpam Teleport Spams]]. If you don't kill him within 30 seconds, you die, and you have the pleasure of taking on the first form all over again!
** And going to the [[VideoGame/MegaManClassic classic series]], Wily's second form in ''[[VideoGame/MegaMan7 7]]'' is often considered one of the most unfairly difficult fights in the series, and the majority of that reason is because of one attack that he spams constantly, summoning four differently-colored balls of energy that lunge forward at Mega Man three times. The attack is nigh-impossible to dodge (you have the best chance if Mega Man and Wily are on the extreme opposite ends of the screen, but it still requires perfect timing), does anywhere from a decent amount of damage to taking out huge chunks of the player's life bar (especially if they get frozen by the blue sphere and can't break free fast enough to escape from Wily's follow-up attack) and is used every time he teleports. You know it's terrible when "Just get hit by one of the yellow spheres because they do less damage" is a perfectly reasonable strategy.
* From ''VideoGame/{{Okamiden}}'', we have Akuro's WaveMotionGun attack. If it hits, not only does it deal out massive damage, but Akuro himself will be healed. The fact that it takes a while to charge isn't particularly comforting, as Akuro's GiantHandsOfDoom can easily grab you and make you a sitting duck for the attack.
* The final battle with Nelo Angelo (a.k.a. [[spoiler:Vergil]]) from ''VideoGame/DevilMayCry'' has him throwing out his deadliest attack, summoning blue energy swords around you and using them on you like ReverseShrapnel.
** Hell Lusts from ''3'' have an uppercut attack. Admittedly it isn't ''too'' powerful, but it has ridiculous priority[[note]]How ridiculous? Death won't stop a Lust getting the move off.[[/note]], the demons love to use it while you're busy fighting others and they sometimes feint it by just doing the starting dash without actually striking, meaning prediction is difficult. [[http://www.youtube.com/watch?v=pItTKI43P5o Behold]] [[http://www.youtube.com/watch?v=j91mP3UtaBQ the]] [[http://www.youtube.com/watch?v=cBdKLPouoOw horror]].
** Also from ''3 '' Vergil's Helm Breaker in the last mission, specially after he says [[TurnsRed "you're going down"]]. The move consists of him teleporting above you and striking you with his sword four to five times in a row, each from a lower height than the last. He may repeat this 2 or 3 times and since he is with his Devil Trigger on he will be recovering health the whole time.
** Again from ''3 '', during the final fight, Vergil has a combo that consists of two swings, a upward swing that launches you in the air (and also hits you if you are above him), he then teleports above you, does a Helmet Breaker and finishes with a Stinger. If you are hit by any of his attacks past the very first swing, it's practically impossible to escape from the combo as well. The last two attacks hurt really bad, even on Normal and on higher difficulties can take a quarter of a fully upgraded health bar. He also loves to spam it, so you better learn to avoid it or DIE.
** He also has the abillity to project purple orbs to damage you, its fairly easy to dodge it in the first and second battle but on the third it becomes almost luck-based.
* [[MirrorBoss Bunji]] [[ThatOneBoss Kugashira]] in the original ''{{Gungrave}}'': "See Ya"/"Not So Fast!" Kicks Grave in the stomach --> shoots Grave while airborne = instant shield break and knocks off 25% of Grave's HP. This attack can KO you should the boss spam it (and he will). The fight even starts off with the boss using it, and it's ''very'' hard to avoid or see coming. It doesn't help that he's the only boss in the game that can ''heal''.
* ''[[VideoGame/DadSeries DadGame]]'' has BonusBoss [[spoiler: Mecha Death]]. It's a freakin' power struggle you have to win. Why is this power struggle on here? [[spoiler: You have to tap with the animation of the key tapping, but more often than not, there is going to be slowdown, and your rhythm will be thrown off just enought that Mecha Death will win this fight by [[OneHitKill instantly killing you]] for a simple mistake. It doesn't help that you may win the first time, but you'll lose the next one, so it really feels like [[LuckBasedMission that you just gotta get lucky on all the power struggles.]] And sometimes, [[TheComputerIsACheatingBastard he does it A LOT.]]]]
* In the ''VideoGame/MonsterHunter'' franchise, the ''most'' agreed upon ThatOneAttack is Plesioth's Hip-check. [[HitboxDissonance The hitbox for the attack is so broken that you could be standing close to it, on the opposite side of the attack's direction, not touching the Plesioth's body, and]] ''[[HitboxDissonance still get hit]]''. It doesn't help that it's one of its only four viable melee attacks while on land.
** Another attack feared by players is Brachydios' "leap slam" in 3 Ultimate; not only does it do massive damage, but Brachydios can leap massive distances making it nearly impossible to dodge this attack by being out of range, since if you're close enough to hit it with anything, it's close enough to leap-slam you. Want to dodge it? Good luck. If it's in rage mode it will cause a huge explosion when it makes contact which is very difficult to simply dodge due to its large radius. Sometimes it well telegraph, but at other times it will give only a split second of warning before it leaps straight at you, giving only a tiny window to prepare yourself. Even then, if you're too close you'll get hit when it takes off, doing as much damage as if it actually hit you.
* The third phase of that flying claw boss in ''{{Frogger}} Beyond'' has an attack which elevates its difficulty to near-LuckBasedMission levels. Basically, it's a leaded cluster of fireballs, followed by a fast fireball. Only problem is, each fireball hits a random spot, and there's no guarantee that you'll survive it. It may have a pattern, but since poor Frogger is a OneHitPointWonder, one hit sends him to the first phase. This means it's nearly impossible to learn the pattern when it kills you every time. May the [[RandomNumberGod gods of random number]] shine on you if it glitches up and fires the attack out of the arena.
* In ''TheLegendOfZeldaMajorasMask'', Gyorg has the habit of swallowing you temporarily after you inflict it damage. This attack is also very difficult to dodge.
** Phytops from ''TheLegendOfZeldaSpiritTracks'' prolongs gradually its thorned tentacle slash combo as the battle progresses. The ultimate combo is: moving its resting tentacles (to make Link's capture of the thorns to hurt it more difficult) while it shoots three series of goo drops, attacking with its left upper tentacle, then with the right one, and finally with both.
* ''VideoGame/InFamous'' has the final boss Kessler. He can and ''will'' hit you with attacks that are almost impossible to dodge, and if he summons his giant copy images, well, best to take cover (but there ''isn't'' any!).
* Yammy in ''[[Manga/{{Bleach}} Soul Carnival 2]]'' has four such attacks:
** 1: His support attack, which sucks you in and deals continuous damage
** 2: His soul-sucking attack, which does the same thing, drains SP and deals damage faster
** 3: Shooting laser bullets from his fists, which can't be dodged unless you're behind him and can't be broken out of except with a support, unlike the other two attacks. He can shoot up to eight at a time, and it can take off over 50% of your health if you aren't buffed up with defense-boosting accessories and/or Soul Pieces.
** 4: His Burning Attack, which freezes time and deals over 3,000 damage. If he does this after the laser bullets, you die.
** Every GiantMook in the game has at least one, whether it's the Doom Gigants' punching attack that can deal ''over 10,000'' damage and send you flying a good distance back, the gigantic Shinigami with a nigh-unavoidable axe attack that hurts like hell, or the turtle Hollows with a splash attack that throws you up into the air.
* {{KOEI}} has quite a few across its [[DynastyWarriors three]] [[SamuraiWarriors signature]] [[WarriorsOrochi series]], most of them handed out by high level characters or officers possessed of a situational super-buff.
** Lu Bu, [[ThatOneBoss at all]]. His moveset is insanely powerful in just about every game he's been in since 3, but it's the throw from ''Dynasty Warriors 4'' that really takes the cake. An unblockable multi hit throw with several officer and infantry mulching swings to tack on damage, followed by an overhead blow that occasionally sends players rocketing across the map, and more often sends their lifeless corpse into the next county, yet when you use it, its [[AwesomeButImpractical Too slow]] or [[TheComputerIsACheatingBastard The damage is too low]]. This move was taken out in 5...to be replaced with a faster, zero-telegraphing fire element dash that breaks block. [[SarcasmMode Thanks, KOEI.]]
** Pang Tong's Musou, in 4 and 5. This often involves him standing in one place and [[TornadoMove doing a lot of tornado air bursts around him]], which often means he'll tack on at least three and often six good hits, and once again blow people off into the distance.
** Gan Ning's Musou, 3 through 5. This attack is powerful, comes out fast, and sends Gan Ning racing across the battlefield at ludicrous speed. If he doesn't actually knock the player character down with the attack, the glancing blow that hits still takes off a good chunk of life, and leaves said character in a stunned state.
** Zhang Jiao's...anything involving his fire element, but his fire based sweeping attack and Musou are fairly obnoxious due to increased damage and leaving players in a 'burned' state for a couple of annoying, vulnerable seconds.
** Saika Magoichi's rifle blasts, especially his Musou in ''Samurai Warriors 1'', which was unblockable for most characters (as 'bullet block' was a rather rare skill). Only his slow attack speed kept him from GameBreaker status.
** Ishikawa Goemon's spinning attack with his mace goes on forever, and it's just fast enough that each hit juggles. Thankfully, he doesn't appear too often in normal gameplay.
** The same can't be said for Maeda Keiji, who gets a block breaking area of effect ground pound ''and'' a brutal multi-hit Musou attack, and happens to turn up in quite a few story modes. He also shows up on his CoolHorse Matsukaze most of the time, so there's no running from him.
** Orochi's moveset, notable his Jumping Fireball that breaks guard, Fire Elemental, and juggles, and anything with relation with Dark Explosion(Air Charge and Charge attack) which is just as broken when you use it yourself, justified as he is the end boss to a MassivelyMultiplayerCrossover.
* ''[[VideoGame/MegaManBattleNetwork Mega Man Network Transmission]]'':
** [=FireMan=] has two; his regular attack which is only dodgeable with good slide timing, and takes off a good chunk of your health. And when his HP gets low, he periodically bursts into a pillar of flame. If you're near him, OneHitKill without the Heat Armor (when you first fight him), and an absurd amount of damage with it.
** [[spoiler:Zero]] has an attack where he lets loose an energy wave that takes up the whole screen and does 300 damage, [[spoiler:a possible reference to the original Zero's {{Sword Beam}} attack mentioned above]]. God help you if you didn't pack an Invis.
* VideoGame/SonicTheHedgehog2006: Silver's psychokinesis. He grabs Sonic/Shadow and slams them into a wall or tosses them into the sky. When the attack starts, it cannot be broken out of. If he slams you into a wall that is close by, or tosses you straight up, he WILL catch you with it again immediately before you can start moving again, ignoring mercy invincibility, and proceed to kill you, or, if you manage to repeatedly land on dropped rings, catch you in an infinite loop.
* ''VideoGame/AssassinsCreedI'': Enemy {{Counter Attack}}s are pretty much impossible to predict and a free hit for the one responsible. Best hope no one takes advantage of Altaļr getting laid out.
* ''VideoGame/CustomRobo'' has the Waning Arc and Waxing Arc guns. Each one fires four shots that can go around walls, and have slight homing. It really hurts if all four rounds connect. Very late in the game is a DualBoss battle that utilizes both of these guns, in a stage with shifting terrain.
* Chronoforce of ''VideoGame/MegaManZX Advent'' has an attack where he swims into the background, shoots homing icicles at you, then ''reverses time'' to make them ''unexplode'' and fly back to him. If you didn't memorize where the icicles went you will get hit at least once as they rewind.
** Another attack of his shoots icicles in roughly a 90-degree arc, with holes in between each icicle. However, on Expert Mode, he shoots off an extra set that goes in between the shots of the first one, making it nigh-unavoidable. Also, because you're playing Expert Mode, Chronoforce will have a permanent Time Bomb active; ergo, all his attacks move twice as fast as they normally would.
* Just about every enemy in ''DarkSouls'' can be lethal if one is not careful, but there are several enemies with attacks that amount to a one-hit kill unless - and even if - ButtonMashing is employed. The Hellkite Dragon in Undead Burg has four variations of his BreathWeapon that will reduce most players to cinders in one go, the [[WhenTreesAttack Ents]] of the Darkroot Garden give [[DeadlyLunge a whole new meaning to tree-hugging]], and the [[ChestMonster Mimic]] enemies look like ordinary treasure chests until opened, whereupon they proceed to messily devour the player.
* In ''VideoGame/Bomberman64TheSecondAttack'', one of the two possible final bosses (depending on the outcome of a MiniBoss battle earlier in the level) has an attack that essentially blankets the entire battlefield in a [[BeamSpam barrage of laser beams.]] They come too fast and too rapidly to anticipate and your character moves too slowly to reliably dodge them, meaning you ''will'' get hit if you try to do anything. How do you avoid getting hit, then? Against all your gaming intuition you've built up over the years, you will be able to almost always get away scot-free... ''by standing still.''
[[/folder]]

[[folder: Platformers]]
* [[spoiler:Tiki Tong]], the final boss of ''VideoGame/DonkeyKongCountryReturns'', has one attack where he will place his hands vertically at either side of the screen (or just one if one hand has been destroyed) and slam them together. It is nearly impossible to dodge, because the timing for when he will slam his hands together after placing them is not the same every time he does it. The only way to tell when he's about to slam them together is that they show a little flash, which comes a fraction of a second before the slam. Unless you have very good reflexes/reaction time, you ''will'' get squashed in between, losing one of your precious two hit points (or four the first time through)...unless you're playing on [[HarderThanHard Mirror]] [[OneHitPointWonder Mode]], in which case the first half of the boss battle might as well be a LuckBasedMission. If you are lucky, he won't use ''that attack'' and instantly kill you. [[spoiler:Unless you trick it out by bouncing off his hand before he slams it.]]
[[/folder]]

[[folder: First-Person Shooter]]
* ''[=ScoreDoom=]'', a standalone GameMod for ''VideoGame/{{Doom}}'''. Its custom boss or [[BossInMookClothing miniboss]] monsters have at least one. Here are several egregious examples:
** The Annihilator's homing missiles deal heavy damage, and are really hard to dodge, even in wide-open spaces (especially painful if said areas lack cover).
** The winged goat demon Azazel's "stunned" state will make him shoot out ground-hugging fireballs that can rip through you, dealing incredible damage in a short amount of time. The fireballs are really fast as well.
** The Demolisher's BFG cannon can [[OneHitKill outright obliterate you]] on a direct hit; however, he sometimes fires two shots, with the second one likely to finish you off; on top of that, the twin super gattling guns can shred you twice as fast if you don't hide.
** Hellsmith's three-way explosive fireballs may as well be a OneHitKill on a direct hit, since each of said fireballs split into multiple explosions as well.
** Every single one of Moloch's attacks are brutal, especially the hell grenades (very tough to dodge in tight spaces and deal massive damge) and nail barrage (these blaze through the map and rip through you for pretty large damage, and they rebound too).
** Scourge's homing missiles can instantly kill you on a direct hit, and they're pretty fast to avoid as well. What's worse? He launches them in three sets of two. There's also that flamethrower attack of his that has a decent range but can quickly empty your health in seconds. Ouch!
** The Dark Cardinal's homing energy ball nova attack is really annoying considering the mini fireballs home in on you and the attack goes off every time he flinches.
** The Terminator's plasma grenade attack will total your health and armor on a direct hit, and it does severe damage if you're in the blast radius. It's a nightmare to dodge in tight spaces.
** The Pyro Demon's teleport explosion attack is not only extremely damaging (splash damage ahoy) and a huge pain in the ass to avoid, he tends to do it pretty frequently sometimes. Mitigated somewhat in that he sometimes does it anyway even if you're not on the same level he is ''and'' he can't get down or up from there.
** Thamuz's hard-to-avoid homing plasma ball can take you out instantly as well if it hits (that's without armor in this case); the ring of fire attack makes him invincible until he finishes the attack by sending the ground-hugging flames out (which only go straight, thankfully)
* ''VideoGame/Left4Dead''
** The Charger or The Jockey from ''VideoGame/Left4Dead2'' when on a level with ledges that kill you. A well placed charge from a charger can [[TotalPartyKill kill an ENTIRE TEAM]].
** Also, Smokers on a level with holes you go down but can't go back up. Three teammates drop down, and the fourth is snagged before they can follow.
*** Hunters and Jockeys are also the bane of the slow ponderous player in these situations too. Second chances are rarely given among survivor players and most players who don't "get with the programme" the first time around and fail to jump down the right hole at the same time as the rest of the team are often summarily booted from the game if they get pinned/snared and become unsaveable.
*** Likewise for infected players, it is extremely difficult to pin/snare a survivor player and kill them before their buddies shoot you and rescue them (you are vulnerable to other players when pinning one and cannot move until your pinned target is dead). Therefore pinning/snaring a slow, clueless survivor player who didn't jump down the one-way hole at the same time as the rest of the survivor team is seen as a CrowningMomentOfAwesome for the infected side and a benchmark by which to measure a player's skill as an infected.
** Anything from the Tank. On Expert, both of his attacks will incapacitate you in one hit, and he's scarily accurate with the cement throw[[note]]If you are facing against an AI Tank, change directions at soon as he throws and you can usually dodge the rock throw[[/note]]. On any other difficulty, one of his punches sends you flying, which can range from being a minor nuisance to sending you flying off a bridge/rooftop to your instant death, and the developers love putting instant death falls on finale levels, the only place where you're definitely running into a Tank. And you don't respawn during the finale event. Punching cars/debris counts too since it's another instant incap, regardless of difficulty.
** Any attack in the game that damages also causes flinching, the Common Infected will reduce your speed to nothing if three or more are hitting you at the same time.
** For anyone playing as the Special Infected, the Survivors' melee attack will stagger you long enough for them to move away and kill you, or they could kill you using just the melee attack if they're feeling sadistic, which most people are in Online Versus.
** It gets even worse for the Tank: if your Tank dosn't have access to cars or cover to get to the survivors, the survivors will simply shoot the Tank player from a distance. Each shot causes flinching which will slow the Tank; with all four survivors wielding machineguns in a wide open area without any cars to throw, the Tank usually dies in seconds when survivor teams do this.
** One attack from survivor players annoy the hell out of Tank players: Fire. If they hear a Tank appear, survivor players will use their molotovs as soon as the Tank player is in their sights or shoot nearby gas cans as a substitute. Once caught on fire, the Tank will keep taking damage until it dies, frustrating the infected team to no end. If there's any water nearby, then you're not as screwed.
* ''VideoGame/TeamFortress2'':
** The Degreaser + Axtinguisher combo. The Degreaser is a flamethrower that allows the user to switch weapons much faster, while the Axtinguisher always deals a CriticalHit if whatever it hits is on fire but deals reduced damage otherwise. Together, this means if you get in the range of a Pyro with this combination, [[InstantDeathRadius you're dead.]] You will be lit on fire and struck with a 195-damage attack that will OneHitKill anything but a Heavy within less than one-and-a-half seconds. Some Pyros use the "Puff & Sting" combination, where they use the compression blast feature to push you into a wall, disorienting you and preventing you from fighting back, and then {{One Hit Kill}}ing you. Fortunately, the Love & War Update changed the Axtinguisher so that attacks from the front only result in a mini-crit, not a normal crit. [[labelnote:*]]Mini-crits deal 35% more damage than normal. Critical hits deal ''300%'' more damage. That's a big difference.[[/labelnote]] This means Pyros can't just shove you into a wall and kill you as quickly as before. If one sneaks up on you from behind and you don't notice, though, you're fair game: attacks from behind result in crits.
** During the Halloween 2013 event, there were several "magic spells" that could be used. The most annoying was the Ball O' Bats. It's a thrown projectile that explodes, throwing whatever it hits into the air and causing bleed (damage over time). The blast radius for this projectile is deceptively large, and whoever gets hit goes ''flying'' straight up. If players were being chased, they could just use this, knock their assailant into the stratosphere, and escape. It was also a very common spell to obtain.
** The Spy's Red-Tape Recorder. It's a sapper that, instead of dealing damage, reverses the construction of the building it's attached to. This happens ''very'' fast, meaning that it takes less than 6 seconds of inattention for a building to be set back to level 1. It's horrible at actually ''destroying'' buildings (the initial building time is ''much'' longer than the upgrade time), but it's very good at wasting Engineers' efforts and time.
* ''VideoGame/{{Borderlands}}'' has the Roid Rage Psycho's Grenades. The boss seems easy and it's child's play to snipe his overly large head. And then he throws a grenade that will completely destroy your health and shields if it hits, leaving you open for him to kill you. To make it worse, he has a spread mod, so every single grenade will spit up into 6.
** The Destroyer's shockwave attack. It's not very damaging, oh no. There are two issues: First, it pushes you out of cover, so it can get you with it's other attacks (Plus it's a pain to keep running back to cover) and two, prepare to throw your controller against the screen if you happen to be even remotely close to the edge when he uses it.
** Wilhelm in [[VideoGame/{{Borderlands2}} the sequel]] has one. There's a train car in the area you find him...he comes out from underneath the train car and throws it. If you're standing near it, [[OneHitKO you die]]. You don't go into Fight For Your Life, ''you die''.
[[/folder]]

[[folder:Simulation]]
* In ''VideoGame/CrushCrumbleAndChomp'', a single shot from the MadScientist will cause the monster to gradually slow down (simulated by giving the player fewer opportunities to enter commands). This eventually proves fatal as the humans' attacks gradually overwhelm the monster. Similarly, moving into a space with a power plant results in an immediate game over.
[[/folder]]

[[folder:Roguelike]]
* In ''VideoGame/{{Angband}}'', Ancient Multi-Hued Dragons and Drolems are notorious for killing players who descend to 2500' without poison resistance. Players without it will take 800 HP of damage from a single breath. From off-screen.
* In ''VideoGame/TheBindingOfIsaac'', there are many attacks that are incredibly difficult to dodge, especially if you're playing as a slower character. However, one that stands out is the attack used by the Leapers. They hop around the room like their lesser cousins, Hoppers, until they leap so high they fly off the screen and crash down near your character, sending out a fast blood shot in each cardinal direction. This gets very deadly when there are multiple Leapers in a room. However, far more devastating is the version of the attack used by Peep, where twelve [[{{Squick}} urine shots]] are fired very quickly in a radial pattern, then eight more are fired right after.
* In ''FTLFasterThanLight'', boarding drones are one of the most dangerous things you can encounter. They bypass all shields except Zoltan Shields, never miss, and punch a hull breach into whatever room they enter - and that's all before they start attacking. They have as much health as a Rockman and an immunity to suffocation, so killing them is a major pain. And if you kill one while the enemy's drone control is online, they'll just fire another, which will punch another hole in your ship. Even if you can take the drone control offline, you still have to destroy the drone itself and repair the hull breach. The only good thing is that a Defense Drone mk1 can shoot them down, but they tend to fire so rapidly that they'll get by a drone fairly easily. Oh, and the Rebel Flagship uses these in its second form.
** Missiles are already bad enough as they [[ArmorPiercingAttack already pierce all shields]] except Zoltan Shields. The [[FinalBoss Rebel Flagship's]] Triple Missile Launcher fires ''three'' in succession. At best, a defense drone of any make can take down two missiles, and while you can cloak to dodge them, this only works every other time due to the longer cloak recharge. Thankfully, you can teleport your crew into the missile control room to take it offline.
** The Rebel Flagship's [[LimitBreak Drone Swarm]]. When it happens (and you do, thankfully, get warned well in advance), the Flagship launches six drones; three anti-ship drones, three beam drones. If your shields drop for even a second, the beams will slice your ship to ribbons, and if it takes out your evasion or shields, you're probably already done for.
[[/folder]]

[[folder:Strategy]]
* ''VideoGame/BleachThe3rdPhantom'':
** Sennen Hyourou. It deals a medium amount of damage, stops you from moving or attacking, AND lowers your accuracy and evasion. And it can hit the 4 squares around its target, too? That means MORE characters that get affected by it! It doesn't help that Hitsugaya has to be in Bankai when he uses it, so you'll take even more damage that isn't connected to that attack (In Bankai, anyone within a two-space radius of Hitsugaya takes damage and can be potentially frozen, lowering accuracy and evasion.)
** It's not an attack, but Absolute Defense is too horrible of a move to not mention it. A character with this will randomly (much more often than not) take single-digit damage from ANY attack. Yes, even Co-Op attacks. A lot of bosses in [[BonusDungeon Kisuke's Tower]] have it, and it is ''extremely'' frustrating.
* ''VideoGame/FireEmblemTheSacredStones'' has the Silencer skill. It is the reason why Assassins are almost never seen as enemies; half the chance they have of landing a critical hit becomes a chance to '''instantly kill the other unit'''. And there is no defending against it; when the Assassin sprite flickers, you're losing someone.
** Fortunately, no Assassins appear as enemies in Sacred Stones. The only occurrence of an actual assassin as an enemy character is in Blazing Sword, and depending on the path you take, you might not even fight him. ([[spoiler:He shows up as a reanimated corpse during endgame, though, and you do have to fight him, but since he and every other boss on that map have 0 Luck, this isn't hard.]])
** As of ''VideoGame/FireEmblemAwakening'', enemy Assassins do exist. Specifically, you can face actual ''player-trained'' Assassins in Streetpass battles! Which means they'll most likely have capped Skill and thus a ridiculously high Lethality chance. Oh, and it gets better: due to the new class-based skill system, ''even non-assassins can have Lethality now''. Oh, and it now works for ranged weapons (Assassins can now use Bows) and even ''magic!'' [[ThisIsGonnaSuck Have fun!]]
** Another example would be the Hel spell in Seisen no Keifu. Basically, it's an HPToOne attack. In a game with FinalDeath. And unlike Eclipse in the GBA games, ''this one can actually hit you.'' And if your HP already is 1, '''it kills you'''. And the enemies with this spell come in ''groups''??
** Some [[GameMod ROM hacks]] bring their own horrible weapons to the table, such as [=GhebSaga=] with the Demi Lance. It hits for 1/2 of your maximum health, but has the Brave effect, meaning it ALWAYS attacks twice. It also can be thrown for a ranged attack. The only thing that doesn't make it completely rage-inducing is the fact that its accuracy isn't the greatest, but it's still able to kill you instantly.
*** [[HPToOne Bane]], used by Whispers in [=FEGirls=]. All Whispers have the Kard, which allows for critical rates to reach the {{cap}} of '''255%''', and Bane has a (critical chance / 2) chance of activating on each attack. Just pray there aren't any other enemies around.
** [[spoiler:Ashera]]'s Judge attacks are grossly powerful and some of them can hit twice, from anywhere on a map. Not to mention the [=AoE=] attacks this boss packs on top of this...
** Glower in ''[[VideoGame/FireEmblemAkaneia New Mystery of the Emblem]]''. Not only does it ignore the target's resistance, it also has significant accuracy and damage, and in this game, dodging is unreliable, meaning it will hit you much more often than not.
** Counter in ''VideoGame/FireEmblemAwakening''. Any damage taken at close range is returned to the person who inflicted it in full, and this skill ''always'' activates on a close range attack.
** One thing that makes [[HarderThanHard Lunatic+]] so hard is that enemies will almost always have a skill like Vantage+, Luna+, Hawkeye or the aforementioned Counter, or any combination of the four from as early as ''the Prologue.'' Vantage+ makes it so that the enemy ''always'' attacks first, Hawkeye means their attacks ''will'' connect (except on a lucky Dual Guard), and Luna+ ''always'' makes their attacks as strong as if your Defense/Resistance was halved.
** Bolting in FireEmblemElibe is a Thunder book that allows Anima magic users to attack their foes in a ''far'' longer range than say, normal tomes (which as much give you a 2 square range). Depending on the user's Magic, this can potentially cover ''more than half the screen''. For worse, more than one Bolting is in the paws of ''a stage boss'' (like Ursula and [[spoiler: Sonia]]), or if not, in the hands of Mages/Sages with decent Magic stat. Say your prayers whenever a Bolting user is in your map, you'll need the luck.
** If you think Bolting is bad, Blizzard from the fifth game is even worse. Think Bolting, but [[BlowYouAway Wind elemental]]... except it also '''puts the target to sleep.''' And in this game, sleeping characters are forced to dismount and can be captured instantly, so be prepared to lose their entire inventory if there are enemies nearby!
** Said game also had the basic Dark magic spell, which causes Poison. This wouldn't be so bad in other games, but in this one status effects ''last the entire chapter'' unless you're willing to use a hard-to-come-by recovery staff. And the most unfair thing about this spell is that, while you do get a playable Dark Mage eventually, [[MyRulesAreNotYourRules that spell only causes Poison when used by enemies.]]
* The Titan Dweevil's Monster Pump in ''{{Pikmin}} 2''. It shoots balls of water everywhere and has incredible reach. If you're not paying attention to both of your pilots you could potentially end up with your entire army drowning.
* Stun grenades from ''JaggedAlliance2''. Everyone within the area of effect, which is quite large, has their stamina bar take a ''huge'' hit that will almost certainly render them unable to perform any action during their next turn. And if you're lucky, some of them will have recovered by the turn after that. You can mitigate the worst effects of this one whilst outdoors by not letting your team get bunched up, but heaven help you if you run across a Mook with one of these whilst trying to fight your way through a narrow corridor.
* The online Bleach game ''Soul Arena'' has balance patches released for it every so often, so abilities that fit this description are usually nerfed after a little while. However, the abilities "Metastasis" and "Kill, Shinsou" currently count.
** Metastasis inflicts 15 (out of 100 HP) damage to an enemy every turn until they die. On top of this, its user heals every turn and gets a defense buff that lets him shrug off weaker attacks.
** Kill, Shinsou also deals constant damage that starts at 5 and ''doubles every turn''. Metastasis can end early if its user is killed; however, if the user of this skill goes down, ''this skill persists''. So if you get hit with Kill, Shinsou, you are going to die, no ifs, ands or buts.
[[/folder]]

[[folder:Tower Defense]]
* ''VideoGame/PlantsVsZombies'' has Dr Zomboss' desperation attack, in which he drops a caravan onto six of your plants, [[OneHitKill instantly squashing them]]. Unlike most of his other moves, this one cannot be avoided. Thankfully, it is predictable (he only uses it once he is below half health, immediately after he gets back up from attacking). It gets used much more frequently in the "Revenge of Dr. Zomboss" minigame, where it becomes exponentially more aggravating. The sequel introduces the Gargantuar Prime, who acts like a Gargantuar with an extra attack- sweeping EyeBeams that OneHitKill up to two plants in your back rows. They can easily devastate a garden if they get to use it one too many times.
* [[FinalBoss The Destroyer]] from ''VideoGame/MiniRobotWars'' merges two of [[VideoGame/PlantsVsZombies Dr Zomboss]]' attacks and cranks it up to eleven. Its deadliest move has it open its mouth and fire out a WaveMotionGun at two of your rows. Sure, you can move a few of your minirobots out of the way, but this attack will most likely destroy any non-defensive unit in the area of effect. Worst of all, this attack comes out ''without warning'', unlike Dr Zomboss' caravan!
[[/folder]]

[[folder:Racing]]
* Though several items and weapons in the ''VideoGame/MarioKart'' series can be jarring and chaotic, both the Spiny Shell and the Thunder have gained notoriety for toughening the races for the players, especially the former for the first-place rider. It's for this same reason why they're considered a ScrappyMechanic, though the introduction of the Super Horn in the eighth installment has the ability to nullify the former.
* The Quake in the ''VideoGame/{{Wipeout}}'' series, a super-fast wave that can travel the length of any given circuit. And getting hit with it makes you lose control and slow to a crawl.
** EG-R's super weapon in ''Fusion'', a set of drones that circle a car and fire constantly until either they run out of ammo or you die. Which one comes first depends entirely on whether or not you are at or close to full shield energy.
** In ''VideoGame/{{Pure}}'', the Disruption Bolt. It does no damage, but it causes one of many negative effects, ranging from [[InterfaceScrew the camera shooting in and out]] to your airbrakes being disabled. The one good thing about it is that it has a small chance of instead activating the autopilot.
[[/folder]]

[[folder: MOBA]]
* DOTA2:
** ''Death Ward'', the main reason alot of players play Witch Doctor, spawns a single ward which proceeds to do a highly convincing imitation of the Fountain's InstantDeathRadius. This actually ''chains'', which means that Death Ward actually hits ''harder'' than the Fountain. The fact that he also has a chain-stun spell and one that does more damage the more damage he already took doesn't really help matters either.
** [[DoomyDoomsOfDoom Doombringer's]] ''[[DoomyDoomsOfDoom DOOM]]'' Ability does two things: one, it adds a powerful but not too unique Damage Over Time effect to the target; two, it shuts down ''everything'' short of autoattacks and moving. For ''fifteen seconds''. In a game where the entire team can be killed in around 5 seconds of combat, that's a massive amount of time you're stuck just sitting there.
* LeagueOfLegends:
** "Requiem", the ultimate spell cast by Karthus, is able to deal massive damage to the entire enemy team no matter where they are on the map. Did we also mention that he could cast this spell when he's dead?
* [[VideoGames/{{Smite}} Smite]]
** "Valkyrie's Discretion", the ulti used by Freya. She flies into the air, making her invincible as she deals massive splash damage that has a very long reach, doubled with her high speed and ability power. This spell has been known to wipe out entire teams when used right. It will make you dread those three words:
--> "To The Skies!"
[[/folder]]

[[folder:Non-Video Games]]
* The [[http://en.wikipedia.org/wiki/7-10_split#7.E2.80.9310_split 7-10 split]] in bowling. Trying to turn one into a spare? GOOD LUCK. The U.S. Bowling Congress used to give out an award for any confirmed 7-10 conversion in an amateur league.
* ''MagicTheGathering'' has a whole "restricted list" in Vintage and a "banned list" in other formats. Every last one of those could be ThatOneAttack. Three cards even annoy the judges so much that they're banned in Vintage: [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=980 Shahrazad]][[note]]Creates a game within the game[[/note]], [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=603 Chaos Orb]], and [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=1571 Falling Star]]. There are other Vintage-banned cards, but they use [[http://wiki.mtgsalvation.com/article/Ante ante]], a mechanic involving changing ownership, something never done in tournaments.
* The ''TableTopGame/YuGiOh'' Trading Card Game has several, but the effect of "Chaos Emperor Dragon-- Envoy of the End" takes the cake. For 1000 Life Points, the player can send ''every card'' on both sides of the field '''and''' in both players' hands to the Graveyard, inflicting 300 points of damage ''per card''! [[GameBreaker You can see why the Chaos Dragon was quickly banned from competitive play]]. "Cemetery Bomb" has a similar effect, though not as devastating: It does 100 damage to your opponents' life points for every card in their Graveyard.
* In ''Webcomic/{{Homestuck}}'', the bearer of the queens' rings or the kings' scepters are granted a number of powers:
** The most commonly dangerous one is Red Miles, which is the Black Queen's signature attack. When used, the Miles will hunt down ''anyone or everyone on a planet'' and stab them through with a OneHitKill. If this is done to a Genesis Frog from outside the universe it embodies by an especially powerfully prototyped ring, it can ''kill off that universe after impaling everyone and everything in it''. The only way to escape is to either flee the universe or to be travelling so fast that the miles can't track you. This attack is why it is imperative not to allow the Black Queen's ring to fall into the hands of any of her agents.
** In the Trolls' session, Feferi prototypes her sprite (and thus all the monarchs) with a city-sized EldritchAbomination whose psychic scream can kill off ''every member of her species in the galaxy'' except for her and the Empress she's in line to replace. Unfortunately, the Black King of their session gains this ability, requiring a truly stupendous number of alternate timeline clones of her group's strongest psychic to nullify.
* If you're not prepared for it, the spell Harm from TabletopGame/DungeonsAndDragons can qualify. A successful shot will reduce you to 1d4 HP ''regardless of how many you have''. (Granted, it can be resisted, saved against, interrupted, countered, etc.) And there's the arguably-more-annoying reverse spell, Heal, that can restore a boss to full health from whatever it happens to be at. This is precisely why Harm and Heal were capped to 150 points of damage or healing in 3.5 Edition.
** [[WordOfGod The developers of 3.5]] consider any attack which results in [[LevelDrain level loss]] to be AFateWorseThanDeath, and grounds for immediately rolling a new character.
** The [[ThatOneBoss Adamantine Horror]] gets ''Mordenkainen's Disjunction'' as a spell-like ability, to [[BreakableWeapons destroy all your buffs and magic stuff]], many levels below when anything else does.
[[/folder]]

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