For one reason or another, people can't give birth anymore. This is often but not always due to a plague inflicted upon a species due to a DepopulationBomb dropped on them by their enemies, hence the name. However, this can just as easily be caused by a natural plague, biological changes in a species which might prevent sex, or a [[ValuesDissonance cultural phenomenon]] causing people [[SexIsEvil to be]] [[ParalyzingFearOfSexuality terrified of heterosexual sex]] (or at least pregnancy). Most horrifyingly, perhaps your enemies just decided to come along and [[GroinAttack castrate all your males]].

Of course, the most popular agent for this problem by far is genetically engineered disease. If you are considering what type of Depopulation Bomb to use on your enemies, you may consider the Sterility Plague the best option for many reasons. First of all, it is a very covert and completely humanitarian method of mass genocide. It will not kill a single enemy civilian or combatant. It is incurable, except where the forces of pure good are involved (But really, what can't they fix?). Your enemies will live just as long as they would have otherwise, but they will not multiply and will cease to be any threat at all after a generation or two. If your race is particularly long-lived then you might consider waiting for everyone to die to be not such a big deal.

Then again, if you are short lived, this might not seem like much of a solution. Also, it does not do much to kill or disable the enemy besides lowering their morale. In fact, it might just really piss them off. And, if they have artificial means of reproduction (or can develop one before the existing population dies out), a Sterility Plague may be a really dumb idea.

If your civilization for one reason or another has decided to completely abandon sexual reproduction (possibly in favor of [[UterineReplicator artificial means]]), expect this to become a major issue soon after the story starts. In fact, unless sexual reproduction can be rediscovered by your race, expect disastrous if not nightmarish consequences. This is probably a little homophobic (especially if you have only abandoned heterosexual sex) and a lot allegorical.

Lastly, you can expect any KnightErrant or civilization-redeeming [[MessianicArchetype Messiah figure]] who comes along to cure the Sterility Plague in the space of a single episode or two-hour feature film. The forces of good make fertility a point of focus, often impregnating [[MysticalPregnancy virgins]], [[MisterSeahorse men]], and [[LawOfInverseFertility the infertile]], so you shouldn't be surprised when they pull double duty by curing a plague and bringing pregnancy to the downtrodden masses.

Compare {{Gendercide}} and ThePlague. Likely to result in a ChildlessDystopia and/or a BreedingCult. Sometimes may result in MandatoryMotherhood, or those that ''are'' fertile (women in particular) being forcibly used as [[BabyFactory baby factories.]]



[[folder:Anime & Manga]]
* ''Anime/FafnerInTheAzureDeadAggressor'': The Festum did this to Japan, prompting the Alvis project which gave rise to artificial reproduction, and, by the same token, genetically engineered {{supersoldier}}s (i.e. our heroes) born to fight the Festum. The plague is cured somehow by the final episode as a SomeoneToRememberHimBy.
** Specifically, what happened was that when Japan was turned sterile, the rest of the world got scared shitless that the Festum had that kind of power, and were even more scared that it was contagious (it wasn't). Their solution? Nuke Japan into nonexistence. The surviving Japanese basically said "screw this, we want to live", and then went ahead violating every ethical code in the book when it came to bio-engineering and cloning in order to ensure their survival.
* ''Anime/{{Vandread}}'': The heroes come across a planet in the second season which had this done to them by Earth. Needless to say, they cure it.
* In ''Anime/MobileSuitGundamSEED'', Third-generation Coordinators (like Lacus Clyne) suffer from this, due to their modified genes and the human body being unable to handle the changes correctly. During both it and ''Anime/MobileSuitGundamSEEDDestiny'', there has been no cure to this infliction and many Coordinators (such as Patrick Zala) refuse to entertain the idea of mating with Naturals (unmodified humans). "Marriage laws" to boost fertility are mentioned in passing several times, although what exactly these laws are isn't ever explained. It might explain why Athrun and Lacus were engaged at a young age, though, and the fact that Yzak's mother gave birth to him at 17 is apparently a result of their aggressive pro-birth policies.
** In ''Anime/MobileSuitGundamWing'', it's mentioned that early in the history of the Space Colonies, natural pregnancy and childbirth was difficult and pretty much always [[DeathByChildbirth deadly]], [[RealityEnsues because of microgravity, cosmic radiation, and so on that humans just aren't adapted to]]. The way around this was to grow babies in {{Uterine Replicator}}s, until at some point, a way to have a safe natural pregnancy was discovered. All 29 of Quatre's sisters were grown in {{Uterine Replicator}}s. Quatre's mom wanted to give birth to her husband's son (and [[HeirClubForMen heir]]) naturally, and she did, but because she didn't have the workaround (whatever it was) she died right afterwards, with her husband asking her if it was ''really'' worth it. He elects ''not'' to tell Quatre about the circumstances of his birth, so that he wouldn't blame himself, which results in Quatre {{Angst}}ing about being easily replaceable, until the Manguanacs set him straight.
* In ''Manga/AnimalLand'', the Zelyda Disease is what killed off [[spoiler: the original humans of the world.]]
* In ''The Boyfriend Story'', one of the stories in the horror manga anthology ''Screaming Lessons'', this is brought about by humans perfecting a cell app that allows for the creation of perfect holographic replicas to serve as the existing humans' companions of any sort. Friends, lovers, spouses, children. With this, the need for meaningful human interaction and consequently birth rates plummet, leading to a world populated solely by replicas.
* ''LightNovel/SundayWithoutGod'': For whatever reason, when people stopped being able to die, they also stopped being able to give birth. This makes Ai's existence even more perplexing, as she was born three years ''after'' that fateful day God supposedly abandoned humanity.

[[folder:Comic Books]]
* In one storyline in ''ComicBook/CaptainAmerica'', Superia attempted to release a plague that would sterilize the world's female population except for her and her cadre of supervillainesses. As the only fertile women in the world, they would essentially have been able to hold the world to ransom. She didn't seem to have considered the idea that the world would probably decide to hold ''her'' prisoner in order to [[FridgeHorror use her as breeding stock]] to prevent the human species from dying out.
* An Creator/ECComics story (based on a prose short story) has female sterility happen as a result of cosmic radiation--after enough years that even the last born child is a senior citizen, they finally develop a time travel gate with the catch that [[ItOnlyWorksOnce they can only set it up once]], and it will be immobile. And travel to the future renders one amnesiac. So the future people set up their gate/trap in New York City in the 1950s; lots of people there to grab. But everyone who comes through the gate is male! [[spoiler: Turns out they've set their time gate up in the men's room at Grand Central Station, a place no woman would voluntarily enter.]]
* In almost the ExactWords of the Laconic ("No more mutants!"), the Scarlet Witch used her {{Reality Warp|er}}ing powers to not only depopulate the mutant species, but also to prevent mutant births from happening in the future. Since ''ComicBook/HouseOfM'' ended, there have only been ''six'' mutant births in total. This was undone at the end of ''ComicBook/AvengersVsXMen''.
** The ''ComicBook/AllNewAllDifferentMarvel'' era gives us the M-Pox, a disease caused by the [[ComicBook/TheInhumans the Terrigen Mists]] which causes sterility in mutants. A lot of the X-Men's story during this era has been trying to stop this while trying to play nice with Queen Medusa and the royal family.
* A major plot point in the Gallimaufry arc of ''ComicBook/BuckGodotZapGunForHire'' is the outbreak of an engineered virus that completely eliminates human sex drive.
* Bad guys once dropped a bomb on Vartox's home planet Valeron, rendering his people sterile. Vartox attempted to seduce ComicBook/PowerGirl into [[OnlyYouCanRepopulateMyRace breeding the next generation]], but she instead found a way to cure his people's sterility.

[[folder:Fan Works]]
* The ''Series/StargateSG1'' fanfic ''[[ Bless the Children]]'' by MaureenT sees SG-1 meet a race of aliens with a fertility problem and an unusual solution, the consequences of which drives the plot of the story.
* In ''Fanfic/TheNegotiationsVerse'', it's revealed that all of the newfoals are sterile and haven't even had much desire to mate in the years since their conversions. Celestia states in the third story ''Truth'' that she never intended for this to happen and hoped to rectify it after the war, but it becomes a moot point after Equestria is defeated by humanity and Twilight gets to working on a potion that can give the converts their real bodies and minds back.

[[folder:Films -- Live-Action]]
* The whole premise of ''Film/ChildrenOfMen''. It's 2027, and the last child was born 18 years ago. For some reason, women all over the world just stopped being able to have kids. The world has descended into nihilistic mayhem, Britain is the only still-barely-functioning nation state (and it's an oppressive fascist hellhole) and most people are just sitting around in depression, waiting for the human race to die out.
* ''Literature/TheHandmaidsTale'''s movie adaptation has this as part of its backstory, just like the original book. Birth rates have drastically fallen due to pollution and sexually transmitted diseases rendering much of the population sterile. This spurs an extreme religious sect to seize power, making the remaining fertile women into "handmaids", or sex slaves of the regime's male leaders.
* In ''Film/{{Logan}}'', mutantkind is dying out because no new mutants have been born for twenty years. [[spoiler:This is due to Transigen using GMO corn syrup to suppress the X-gene. However it's never clearly established whether mutant parents simply have non-mutant children, or if they can't have children at all.]]

* The Elven Kingdom of the book series Sanctuary, whose males have all been rendered sterile by a [[spoiler: curse from the God of Death]] have been unable to produce any pure blooded children for hundreds of years, with many Elven woman turning to the lesser mortal races to produce half-breed children instead. One of their most holy figures is the Youngest Elf in the world, the only full-blooded Elven child born since the issue began, who they believe will one day save them from their sterility.[[spoiler: It is later revealed that a small isolated community of elves, who have existed on the edge of the Elven race and are largely ignored, have been able to reproduce the whole time, but have kept it a secret because they feel they owe nothing to the Elven Kingdom, which has long treated them as disposable assets.]]
* ''Literature/ABrothersPrice'' has a variant where women can have babies just fine, but most male babies are stillborn or miscarried. This doesn't seem to affect the population much, though, as sisters usually share a husband. The cause of the SterilityPlague is unclear, the characers don't remember a time where it was different. Due to the nature of the sterility, it is likely that it was caused by environmental pollution, see the real life example for low male birthrate below.
* "But, you see, there aren't any children. They aren't born." The last line and premise of Stephen Vincent Benet's anti-war poem ''Nightmare for Future Reference'', first published in the April 2, 1938 issue of ''Magazine/TheNewYorker'' magazine.
* Due to insufficient research on long term effects, the "cure" for AIDS turns out to be one of these in the first third of the novel ''Literature/TheBreedsOfMan'' by making it impossible for women to have more than one child. The second third is about trying to find a cure for the cure before it's too late, and the last third is about trying to find a way to cure the cure for the cure (since the protagonists just can't stop [[NiceJobBreakingItHero breaking things]]).
* In ''Literature/GulliversTravels'', the Houyhnhnms decide the best way of wiping out the Yahoos is to castrate them all. They got the inspiration for this from Gulliver's description of how horses are treated in England (male horses were castrated to break their spirits and control the population.)
* The novel ''Literature/ChildrenOfMen'' by P.D.James, as noted with the film adaptation, is an archetype of this trope.
* In ''Literature/TheBelgariad''[='s=] past, when Gorim of the godless finally got a god to accept him, he asked for his people to follow and cursed those who refused with sterility. In ''Belgarath The Sorcerer'' he expresses regret on this and surprise that the curse wasn't lifted.
* In ''Literature/{{Bumped}}'', a virus went around causing all adults to be sterile. As a result, adults will pay lots of money to teenagers (and in extreme cases, preteens) to be surrogates.
* In ''Prized'', the sequel to ''Birthmarked'' by Caragh O'Brien, Gaia travels to Sylum, a {{matriarchy}} where 9 out of every 10 babies are male, so females are prized members of society. On top of that, a couple hundred of the men are infertile. It is revealed that [[spoiler: some sort of problem with the water is causing the men to be intersex, thus making them infertile.]]
* ''Le Dernier Homme'' is an 1805 science fiction novel written as a prose poem where humanity as a whole is going sterile. It involves the voyage of the last fertile man to meet the last fertile woman only to meet with Adam, who has been charged by God to convince the couple to not reproduce, thereby allowing the world to end and be reborn.
* In ''Literature/ChildhoodsEnd'' it is mentioned that there is no biological reason for more children to be born, when the existing children start to AscendToAHigherPlaneOfExistence.
* In ''Literature/AlienChronicles'', the Dancing Death severely reduced the population of the Viis, and is believed to be responsible for their now much lower fertility and high rates of mutation. They keep many races of slaves, one of which is ironically an ExplosiveBreeder.
* The villain in one of the ''Literature/DirkPittAdventures'' novels intended to sterilize the human race this way, or at least half of it, as more "humane" than wiping them out. Pitt calls him a "freak" for this.
* ''Literature/TheHandmaidsTale'': A main cause of the revolution that created the Republic of Gilead was widespread sterility. The few fertile women, dubbed Handmaids, are assigned to the households of powerful men for the express purpose of producing children. Unfortunately, if the men aren't fertile, the women are blamed for it. However, Gileadean doctrine forbids men to be mentioned as the ones who are sterile and instead places all the blame on women.
* In the novel ''Mr. Adam'', a journalist discovers that no woman has become pregnant since the accidental explosion of a nuclear weapons stockpile.
* Earth in ''Literature/OldMansWar'' had a more limited version of this a few decades ago; male fertility was sharply reduced, and birth rates still aren't quite back yet in the developed world. Since it was an alien virus, the planet remains under quarantine to avoid a more thorough sequel. Except [[spoiler: it wasn't alien at all; the colonial authority created it to justify the quarantine in a bid to snatch power from terrestrial governments.]]
* In William Barton and Michael Capobianco's ''Alpha Centauri'' the organization known as Indigo developed "autoviroids" that replicate in infected men's sperm and destroy the eggs of women they have sex with. This is intended to solve the solar system's overpopulation crisis. Their agent Mies manages to infect all but one of the women on the Alpha Centauri expedition.
* This comes to afflict all of humanity in ''Literature/{{Galapagos}}'', with the only people unafflicted being a tour group marooned on the eponymous island. As [[LiteraryAgentHypothesis the narrator]] is a ghost who observes said tour group and their descendants, he gets to observe how humanity further evolves from these few survivors.
* The villains of the ''Creator/CliveCussler'' novel ''Plague Ship'' are planning to sterilize half the human race, honestly thinking they'll be hailed as heroes.
* Vashti and Champagne discover in ''Literature/{{Edenborn}}'' that the combination of [[ThePlague Black Ep]] and its treatment leaves women incapable of carrying a child to term.
* Though the female aufwaders in Robin Jarvis's ''Whitby Witches'' trilogy can still conceive, the curse on their race means that, unless they end the pregnancy, their blood will turn to brine, causing an agonizing, and ultimately fatal, illness. As if that wasn't bad enough, the mother will be reduced to a briny sludge and the child, if it survives to term, will crumble to dust within minutes of birth. Only one aufwader born since the laying of the curse has survived infancy.
* A virus spreads through the world in one sci-fi story that causes women to spontaneously abort with the only cure being the women having to consume a diet containing a rare fruit for the duration they want to get pregnant and have a child. It's not a real cure as they'll promptly reinfect as soon as they stop eating. The kicker? It was created and released by the scientist who 'discovered' the cure because he didn't want there to be anymore unwanted children in the world.
* "Fade to White", an AlternateHistory short story by Creator/CatherynneMValente is set in a post-WorldWarIII United States that [[CrapsaccharineWorld maintains the facade]] of TheFabulousFifties. The few men who are not infertile serve as fathers in rotation to several families, who pretend the others don't exist and the father is working at a non-existent job while away.
* ''When She Woke'' has this as the source of its plot. A sexually transmitted disease caused many people to become sterile and birth rates fall dramatically. Due to this, a constitutional amendment has been passed in the US forbidding abortion. Those who have illegal abortions, like the main character, are punished with a gene therapy that turns their skin red (other crimes get some different colors). It's based on ''Literature/TheScarletLetter'', updated to a dystopian future world.
* In James Tiptree Jr.'s short story "The Screwfly Solution", a HatePlague turns male sexual urges into murderous violence against women. The female protagonist concludes that it's meant to depopulate the Earth prior to colonisation by aliens. The title comes from the techniques used to eradicate insects via this trope (see RealLife).
* The final story of ''Literature/TufVoyaging'' features this, as the protagonist at that point figures that the inhabitants of the world of S'uthlam will only react by having more children if he solves their overpopulation crisis by providing a miracle food (this is the ''third'' time he was recruited to do that, and both previous times population growth spiked yet higher when he left). His solution? [[spoiler: He ''does'' provide a food even more miraculous than the last time... with just the minor quirk that it causes sterility in 95% of the humans that consume it.]]

[[folder:Live-Action TV]]
* Franchise/StargateVerse:
** The Asgard suffer from the fact that they have totally abandoned sexual reproduction in favor of cloning.
** In the BadFuture portrayed in the ''SG-1'' episode "2010", the Aschen plan to surreptitiously conquer Earth involves one of these, distributed under cover of advanced medical tech. As shown in the later episode "2001", this is their ''modus operandi''.
* ''Series/StarTrekTheNextGeneration'':
** In one episode there's a group of colonists who had too few people to successfully build a colony, so instead of sex the went the cloning route. Now due to [[CloneDegeneration replicative fading]] they can't do that any more, so they steal DNA from people on the ''Enterprise''. The resolution is that they marry their cousins from {{Oireland}} InSpace.
** In another episode there's a world where all the remaining adults are sterile, and steal the kids from the ''Enterprise'' to be their next generation (no pun intended). [[spoiler:Turns out this world's impressive tech was what was causing the sterility, ensuring the children would become sterile in due time.]]
* ''Series/EarthFinalConflict'': The Companions are sterile; Zo'or is the last one to have been born.
* All the clones in ''Series/OrphanBlack'' are apparently sterile - with the exception of Sarah, who has a daughter named Kira. [[TheFundamentalist Tomas]] immediately decided to hunt Kira down upon learning of her existence, and Delphine purposely hid the existence of Kira from [[EvilutionaryBiologist Dr. Leekie]] when she was spying on Delphine. [[spoiler: It is revealed by Ethan, one of the original creators of the project, that the clones were intentionally made sterile, which also has led to the autoimmune disease that has killed many of the clones. Helena may also be fertile, due to having the same surrogate mother as Sarah.]]
** In season 3 [[spoiler: this trope is played more straight when Dr. Coady wants to turn the infertility defect (which in the Project CASTOR male clones is sexually transmitted) into a bio-weapon.]]
* In ''Series/{{Lost}}'', women who conceive on the island cannot give birth there. Those who try all die. It turns out that the island's electromagnetism sets off an immune response that attacks the fetus, killing both mother and child.
* The second season finale of ''Series/{{Zoo}}'' reveals that [[spoiler: the Shepherds and Jackson's father have planned all along for the "cure" for the animal outbreak actually be to sterilize the human race and return Earth to the animals.]]
* ''Series/TheOuterLimits1995'' revival episode "Dark Rain" concerns a future where chemical warfare has left most of humanity sterile. The rare women wits viable pregnancies are sought out by the government and confined to hospitals so the newborns can be seized as wards of the state.
* A second season episode of ''{{Series/Spellbinder}}'' has the dimension-traveling protagonists find themselves in an Enlightenment-themed world where a deadly plague killed off a large amount of population before a cure was found. Strangely, the cure not only cured the plague but also made people immortal. Unfortunately, the ImmortalProcreationClause is in full effect, as humans are no longer able to conceive. Instead, they build automatons that play and entertain their "parents". When a scientist finds out that the protagonist (a teenage girl and a 20-some man) are fertile, he kidnaps them in order to set up PeopleFarm to try repopulate the world and even breaks their inter-dimensional ship. They manage to fix it and escape.
* ''Series/DoctorWho'': In "The Leisure Hive", the Argolians are a DyingRace who were rendered sterile by radiation in the aftermath of the twenty minute war they fought with the Foamasi.
* [[TheConspiracy The Network]] in ''Series/{{Utopia}}'' have already [[GeneticEngineeringIsTheNewNuke created a very subtle one of these]] and are attempting to deploy it.
* ''Series/TheHandmaidsTale'': Birth rates in the US had plummeted to catastrophic lows by 2015. And of the babies that ''are'' born now, many didn't survive long past birth. This is apparently due to environmental toxins. The Republic of Gilead says it's only women who are sterile [[spoiler: but the doctor Offred sees tells her most of the Commanders are as well.]]

[[folder:Myths & Religion]]
* In the ''Literature/BookOfGenesis'', after Sarah is taken into the Pharaoh's RoyalHarem (and later, that of a local Canaanite king by the name of Abimelech) because her husband grabbed the IdiotBall out of fear for his own safety, {{God}} prevents Pharaoh/Abimelech from leaving her DefiledForever by making him [[TheLoinsSleepTonight unable to perform sexually]] when he's with her. Not only that, but all the women in the harem are unable to conceive and/or have miscarriages. This goes on until Pharaoh/Abimelech figures out that his latest addition to the harem is already married to someone else, and returns her to her rightful husband, after which things return to normal.

[[folder:Video Games]]
* In ''VideoGame/HalfLife2'', the Combine have set up some sort of device which makes humans unable to reproduce. In the expansions this has been deactivated, leading to Dr. Kleiner to suggest that repopulation can begin.
-->'''Alyx Vance:''' Did Dr. Kleiner just tell everyone to... get busy?
* The [[OurVampiresAreDifferent Vampires]] of the ''VideoGame/LegacyOfKain'' series were inflicted this (along with [[ImmortalProcreationClause immortality]] and blood-thirst) by their archenemies, the Hylden, when they banished them. The problem is, the Pillars of Nosgoth, which represent the balance of the world and serve as a seal to imprison the Hylden, chose their guardians among newborn Vampires. When the Vampires ceased to give birth, the Pillars started to choose humans: [[CrapsackWorld it did not end well at all]].
* The Forced Evolutionary Virus in the ''VideoGame/{{Fallout}}'' series renders its subjects sterile, so the only way for Super Mutants to increase their ranks is to capture and mutate more humans. Just as well, they have [[TheAgeless biological immortality]]. The Troglodyte Degeneration Contagion in ''The Pitt'' sterilizes those residents who aren't turned into Trogs or Wildmen (except for Ashur and Sandra, whose infant daughter is resistant to TDC). Ghouls are also universally sterile, although this is caused by radiation rather than a traditional plague.
* Waidwen's Legacy in ''VideoGame/PillarsOfEternity'' is a variation. Children are ''born'', technically, but they're hollowborn, lacking [[OurSoulsAreDifferent souls]] and being nothing but {{empty shell}}s. Attempts to give them souls ended... [[BodyHorror poorly]].
* Zigzagged with the Genophage in ''VideoGame/MassEffect''. Playing it straight, it's a genetically engineered virus that attacks pregnant krogan females, causing alterations to hormone production that result in offspring being too deformed to survive and thus stillborn, and in the second game its revealed that the Salarians had to disperse a new strain of the disease because the Krogan evolved an immunity to the old one. Subverting it, the genophage was intended as a sort of mandatory contraception enforcement -- it's designed to allow a carefully calculated number of offspring to be viable enough to survive (which one of its creators notes was harder than just making it a standard sterility plague) - and its effects as a DepopulationBomb actually owe more to krogan inability to learn from their mistakes (or [[MoralMyopia admit to them in the first place]]) than its own inherent lethality. Mordin at one point outright states that completely sterilizing the krogan would have been considerably easier, the Genophage was designed to ensure that the krogan could survive, just at "pre-industrial" numbers. When asked why not go the whole way and wipe them out, he hotly replies he ''isn't'' a war criminal or mass murderer, and finds genocide morally repugnant.

[[folder:Web Comics]]
* Webcomic/OffWhite: No human babies have been born in the last three years because the human white spirit was eaten alive.
* This is part of the reason of the Elves isolationism in ''Webcomic/ErrantStory'' (That and a healthy dose of OurElvesAreBetter). Misa was the last known full-blooded elf birth and she's 1500 years old. No one knows why and no one's been able to fix it. Note that Elves are only sterile with ''each other''; they can cross-breed with humans with little issue.
* In ''{{Webcomic/Drowtales}}'', members of Zala'ess Vel'Sharen's bloodline start becoming affected by this as a result of their [[DemonicPossession demonic taint]], with the female members either miscarrying early into the pregnancy or giving birth to stillborn and horribly deformed children. It's unknown if this has any affect on the male members, but since drow [[LineageComesFromTheFather trace lineage through the mother]] it wouldn't matter as much to them if it did. It's eventually revealed that this was intentionally done by Zala's sister Snadhya'rune, who chose this method as form of {{irony}} since Zala [[MassiveNumberedSiblings is known for her]] [[ReallyGetsAround many many children]].
* In ''Webcomic/DanAndMabsFurryAdventures'', the Angels' birthrates have sharply declined to the point that they are becoming a DyingRace. It's later implied that [[spoiler:the Dragons]] have something to do with that, and that the Angels aren't the only race they've rendered extinct.

[[folder:Web Original]]
* Wiki/SCPFoundation:
** The Foundation ''accidentally'' did this to an AlternateUniverse Earth ([[ SCP-1322]]), and '''boy''' are they pissed off.
** Exposure to [[ SCP-336]] (Greatly implied to be [[spoiler: UsefulNotes/{{Lilith}}]]) causes this in females.

[[folder:Real Life]]
* This is a common method humans use to eliminate harmful organisms in their environment such as mosquitoes and viruses. Scientists tasked with wiping out a short-lived life form often focus on disabling its means of reproduction. They find ways of infecting, poisoning or destroying stagnant water to stop mosquitoes from breeding, and the only known means of effectively killing viruses is to interfere in their reproductive cycle (i.e. interferon medicines).
* This is also the reason why the pesticide DDT was banned. The chemical bioaccumulates, meaning it remains in the body and active for a very long time after ingestion. This did not have many noticeable effects on insectivores that consumed DDT-killed insects, but as those insectivores fell prey to higher level predators the concentration of the chemical compounded. Apex predators like eagles, ospreys, and other raptors ended up with stunning amounts of DDT in their bodies that had passed through hundreds of other organisms with its potency intact. In birds, DDT causes a defect in the process that creates the hard shells of their eggs. Female raptors were laying eggs with shells so thin that they would break during routine incubation. Since these are species that usually bear rather small clutches, losing so many chicks before hatching caused their populations to plummet steeply. So steeply, in fact, that the US was for some time in danger of having its symbolic animal, the bald eagle, go extinct within its borders. Since the ban on DDT, most raptor populations have rebounded with some help from captive breeding programs and hefty fines on hunters.
* While it's not quite a sterility plague (yet), the heavy pollution in Sarnia, Ontario's Chemical Valley has contributed to a high rate of miscarriages and low (male) birth rate on the Aamjiwnaang First Nation [[ reserve]].
* Similarly, [[ Love Canal]], one of the most notorious toxic dump sites in the U.S., caused a high number of miscarriages among its residents.
* It's not a plague per se, however, the constant spread of [=STDs=] chlamydia and gonorrhea can and sometimes will, if not treated properly or in time, cause sterility when the disease ravages the sexual organs. Likewise, the same can occur from [=HPV=], as said virus can cause cervical cancer.
** HIV, the virus that causes AIDS, is ''effectively'' an example of this: although having HIV doesn't directly incapacitate a person's ability to reproduce, hetrosexual survivors who refrain from unprotected sex to ensure their partners won't become infected are, in effect, removing themselves from the human gene pool.
* The bacterial genus ''Wolbachia'', which infects insects and nematodes, can cause infected male organisms to be infertile with anything except infected females. If such a male mates with a female that ''isn't'' infected, any potential eggs she carries are aborted.