-->I am creation and destruction. I am the power to transform and to destroy. I am every drop of Energized Protodermis that exists, and every drop is me. I am as far beyond you, creature of armor and tissue, as you are beyond an insect.
-->-- Energized Protodermis, ''Franchise/{{BIONICLE}}''

That AppliedPhlebotinum you've known about and have been using since ever? It's alive ... question is, what are its intentions?

Often it has the ability to [[SelfHealingPhlebotinum regenerate]] FromASingleCell. If it's also biological it may also be a LivingBattery. May or may not be an EmpathicWeapon or LivingWeapon.

See also MainliningTheMonster, PoweredByAForsakenChild and ArtifactOfDoom.


[[folder:Anime and Manga]]
* Innocence from ''DGrayMan''; its implied/stated how Innocence "chooses" people or something like that.
* [[spoiler:The Hougyouku]] from ''Manga/{{Bleach}}''.
** And in a far less plot-important example, Kon.
* The Shikon No Tama from ''Manga/{{Inuyasha}}''
* The Paksis in ''{{Vandread}}''.
* Getter Rays from (what else) ''GetterRobo'' are either this or a CosmicHorror.
* The [[Anime/NeonGenesisEvangelion Evangelions]].
* Recent events in ''{{Toriko}}'' seem to indicate that Gourmet Cells are this.

[[folder:Comic Books]]
* In ''ComicBook/{{Empowered}}'', it's gradually revealed that the [[ClothesMakeTheSuperman super-suit]] is sentient to some unknown degree.
* The Blue Beetle owned by the various Blue Beetles has been retconned into this over the years. It was originally introduced as a magical Egyptian artifact that gave superpowers to Dan Garrett, but by the time it passes to a third owner Jaime Reyes it turns out to be a sentient alien machine that gives the wearer a rather ridiculous range of super powers, at the cost of controlling their body and suppressing their personality.

* ''{{Flubber}}''
* The Crystal Skull from the ''Film/IndianaJonesAndTheKingdomOfTheCrystalSkull''.
* The angels in the various angel sports movies: e.g. ''{{Angels in the Outfield}}''.
* The antagonist of SciFi movie ''Fire From Below''. It is a radioactive substance, useful for both a power source and armor plating when depleted. The problem is it seeks certain substances to burn with virtual sentience.

* Dust in ''Literature/HisDarkMaterials''.
* Simon R. Green's ''SecretHistories'' series concerns this, first with [[spoiler:the family's enchanted armor]] is powered by a evil fugitive extradimensional being that eats newborns. The replacement is possibly a good guy, but being a StarfishAlien it's not easy to tell its complete motives.
* In ''Literature/TheMagicThief'' series, by Sarah Prineas, Conn discovers that [[spoiler:the magic of Wellmet is actually a living being, and that spells are its language.]]
* In ''Literature/ThoseThatWake'', Man in Suit is hopelessness given life.
* The One Ring from ''Literature/LordOfTheRings'' and The Hobbit. It can betray its masters, call out to its true master, and actively seeks to be brought to [[EvilOverlord Sauron]].

[[folder:Live Action TV]]
* ''Series/DoctorWho'': you see that blue police box that can travel through time? Well, it's not just the Doctor's space-ship. 'It' is a 'she', and often chooses where the Doctor lands. Furthermore, he didn't steal a ship. ''She'' stole a ''Time Lord''.
** In the new series with the 11th Doctor, the Flesh is synthetic organic material that can be molded into an ArtificialHuman, then used "like a forklift truck" for dangerous situations. Only we discover that it remembers each time is has been 'decomissioned', and because LightningCanDoAnything, sudden powerful electric shocks can meld the current user's personality and memories to the doppleganger leading to a sad WhatMeasureIsANonHuman situation.
** And then there's The Moment. The power by which the Doctor ended the Time War by ending ''everyone and everything in the Time War, including his own people,'' is very much sentient, and helped the Doctor make his decision by letting him meet his [[DavidTennant future]] [[MattSmith selves]]. In the end, the Doctor indeed makes the choice to [[spoiler: take the new option opened by the presence of the other Doctors, but preserve the timeline by making it ''look'' like he went to such drastic measures. Unfortunately, the Doctor still remembers the old history]].

* ''{{BIONICLE}}'': Energized Protodermis and Antidermis.

[[folder:Video Games]]
* ''VideoGame/MetroidPrime'': Phazon. It also happens to be ''[[TheCorruption evil]]''.
* Metatron in ''VideoGame/ZoneOfTheEnders'', the resident Phlebotinum, is at least PsychoSerum and possibly sentient. Without an AI intermediary to "filter" a pilot and metatron the pilot tends to go insane and (in the above case) construct a virtual ghost of a dead lover to embody their genocidal tendencies.
* The lums in ''Franchise/{{Rayman}}''. They're small orbs of energy which usually float towards you. The {{Backstory}} in ''VideoGame/{{Rayman 2}}'' reveals that [[spoiler:they combined their collected consciousness to create Polokus, who would then create the world.]]
* In ''VideoGame/FreedomForce Versus The Third Reich'', [[spoiler: Energy X actually turns out to be]] SentientPhlebotinum. And not exactly a nice entity, either.
* ''VideoGame/GearsOfWar 3'': [[spoiler:Immulsion, which is a parasitic lifeform.]]
* The magic cloth in ''VideoGame/{{Journey}}'' appears to have sentience and, in fact, different species within itself, from small scraps that float through the air together like fish, to a more familiar tassled FlyingCarpet style, to a massive dragon-looking creature. They emit tones just like the traveler, and aid you on your travels.
* The evil artifacts in ''Department 42: The Mystery of the Nine'' had a limited sentience that enabled them to escape the good guys' storage facility and seek out new owners.
* Echoplast in ''VideoGame/AlterEcho'' is a variety of "plast" (material which can be shaped and reshaped psychically) developed in secret by the BigBad which ended up becoming sentient.

* ''WesternAnimation/GeneratorRex'': Alpha, the [[SuperPrototype original control nanite]]. He was made sentient to be able to properly control the nanites to do tasks, but [[AIIsACrapshoot that didn't end too well]]. Any body he makes for himself is basically a swarm of nanites as well... Until he burns through them and has to get ''more'' nanites to build ''another'' new body, at any rate.
** The [[spoiler: Meta-Nanite]] has some sort of intelligence since Rex could talk to it [[spoiler: and order it to cure every Evo in the world. Well, almost every one]].
* In the ''WesternAnimation/JusticeLeague'' episode "Hearts and Minds", the Pitar is sentient and ''very unhappy'' with what the BigBad is doing with its power.
* In ''WesternAnimation/YoungJustice'', The Scarab constantly talks with its host, Jaime. [[spoiler: It later turns into a PhlebotinumRebel when placed back under Reach control, as it prefers working with Jaime to being ordered around by the Reach.]]
* Heavily implied in the case of the [[ArtifactOfDoom Ice Crown]] on ''WesternAnimation/AdventureTime'', most notably when it froze the world out of rage at its wearer's death in an AlternateUniverse.