%% Image selected per Image Pickin' crowner: http://tvtropes.org/pmwiki/crowner.php/ImagePickin/ImageSuggestions41
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[[quoteright:350:[[ComicBook/TheKingpin http://static.tvtropes.org/pmwiki/pub/images/kingpin_roguesgallery_spider_daredevil.jpg]]]]

->'''ComicBook/GreenArrow:''' I can't believe your advice worked. We actually managed to turn ComicBook/RasAlGhul into an ''Series/{{Arrow}}'' villain.\\
'''ComicBook/{{Daredevil}}:''' Hey, it's like I said. We turned [[ComicBook/TheKingpin Kingpin]] from a Franchise/SpiderMan villain into a Daredevil villain in the seventies and I never looked back.
-->-- ''WebVideo/ImAMarvelAndImADC'', "[[https://www.youtube.com/watch?v=TSMPFhZYizE&ab_channel=ItsJustSomeRandomGuy Hi, I'm a Marvel...and I'm a DC...and I'm on TV]]"

Also known as [[http://www.oafe.net/blog/2007/01/the-supervillain-shuffle/ The Supervillain Shuffle]]. The occurrence wherein a villain, originally introduced as an enemy for a specific hero, subtly through time or ContinuityCreep, deliberately or unintentionally, becomes more identified with another hero.

While any SharedUniverse may depict a hero fighting another's antagonist, usually they remain identified with the original. For instance, Franchise/{{Superman}} may occasionally fight ComicBook/TheJoker, but no one would claim the latter is anything but a Franchise/{{Batman}} villain. This trope refers specifically to characters that have reached the narrative point where the villain is now more identified in the popular consciousness as being an adversary to a character he did not originally fight.

Often occurs when an obscure character is used in a recent popular work or adaptation. In many cases, it also happens when the villain is better suited to another hero either thematically or with regard to powers, especially if the themes or powers of the hero have changed in the interim. Can also be the result of a writer creating a villain while writing for one character, then moving on to another project and taking all of their toys with them.



[[folder:Comic Books - DC]]
* Solomon Grundy was originally specifically an enemy of the ([[UsefulNotes/TheGoldenAgeOfComicBooks Golden Age]]) Franchise/GreenLantern. However, due to his appearances in various animated series (particularly ''WesternAnimation/{{Superfriends}}'' and ''WesternAnimation/JusticeLeague''), and the fact that several comic book creators still identify him as a Golden Age villain, Grundy is now more of a standard DC Universe villain.
* Another Golden Age Green Lantern villain, ComicBook/VandalSavage, is also now used as a general DC Universe villain, going up against numerous heroes.
* Comicbook/{{Aquaman}} has a habit of appropriating water based villains that originally debuted in other titles, such as The Shark and King Shark, Shark themed villains who started out menacing Green Lantern and ComicBook/{{Superboy}}, respectively.
* The Shade was originally created as a villain for Franchise/TheFlash, but in the modern age, he's perhaps best known for being a TricksterMentor for the Jack Knight incarnation of ''Comicbook/{{Starman}}''.
* An in-universe version is how the Mist originally fought [[ComicBook/SandmanMysteryTheatre the Wesley Dodds incarnation of the Sandman]] before moving to Opal City and fighting Starman. This fact is used as a plot-point in the 1990s series.
* Doctor Destiny was originally created as a villain for the ''Franchise/JusticeLeagueOfAmerica'', and specifically Franchise/GreenLantern. However, he is now almost certainly best known today for being the sap who got his hand on the magical ruby created by the King of Dreams, Morpheus, in ''ComicBook/TheSandman''.
* Jason Woodrue the Floronic Man, created as an adversary of Comicbook/TheAtom, is obscure outside of his appearances in Creator/AlanMoore's run on ''Comicbook/SwampThing'' and Creator/NeilGaiman making him integral to the creation of ComicBook/PoisonIvy in a ''Secret Origins'' story.
* Hank Henshaw, [[Characters/SupermanRoguesGalleryAToL the Cyborg Superman]] was, unsurprisingly, originally created as a recurring villain in the Franchise/{{Superman}} titles. Later on, he gradually became more of a Franchise/GreenLantern villain due to his actions in ''Reign of the Supermen'' touching off Hal Jordan's temporary FaceHeelTurn, and his eventually joining the [[Characters/GLSinestroCorps Sinestro Corps]]. He never gave up his hatred of Superman, however, and returned to the Superman book for his final Post-Crisis story in "reign of Doomsday". His New 52 incarnation, though, has become a Comicbook/{{Supergirl}} villain entirely.
* The same thing happened with [[Characters/GLOtherVillains Mongul II.]] His father was a Superman villain, and also the one who helped the Cyborg-Superman destroy Coast City. After he was killed for refusing a pact with, and then trying to punch, [[BrokeYourArmPunchingOutCthulhu Neron]], his son appeared a few years later as a foe of Superman. Nowadays, he fights Green Lantern and the Green Lantern Corps.
* Clock King was originally introduced as an adversary of Comicbook/GreenArrow, but is now considered to be a minor member of Franchise/{{Batman}}'s RoguesGallery, due in large part to his appearances in the Franchise/DCAnimatedUniverse. (And [[Series/{{Batman}} the sixties TV series]].)
* Comicbook/LadyShiva was originally the archnemesis of Richard Dragon, but she was later brought over into the Batman mythos, particularly Comicbook/{{Robin|Series}}, [[Comicbook/{{Batgirl 2000}} Batgirl]], and Comicbook/BirdsOfPrey, and has become much more well-known than Richard.
* {{ComicBook/Darkseid}} is a circular example of the trope. He was introduced in Franchise/{{Superman}}'s ''Jimmy Olsen'' title, en route to becoming the specific villain of the Comicbook/NewGods series. With said title's cancellation, he has become associated with Superman's rogues gallery. This likely due to how well he serves as a counterpoint to the Man of Steel: a super-powerful alien who comes to Earth to rule mankind, not serve it, and being one of the few foes of a similar weight class. He's also fairly strongly associated with the ComicBook/{{Legion of Super-Heroes}}, thanks to the classic storyline "The Great Darkness Saga". He's also a popular villain for CrisisCrossover stories that encompass all of Franchise/TheDCU, such as ''Comicbook/{{Legends|DC}}'' in 1986, ''Genesis'' in 1997, and ''Comicbook/FinalCrisis'' in 2008.
* Professor Arnold Hugo (a man who gave himself super-intelligence at the cost of an oversized cranium), debuted as a Batman opponent, but languished in obscurity until he was reused as a ComicBook/MartianManhunter foe, reappearing several times.
* Franchise/{{Superman}}'s first supervillain was the Ultra-Humanite, but he was {{retcon}}ned to be a ComicBook/JusticeSocietyOfAmerica villain after [[UsefulNotes/TheGoldenAgeOfComicBooks Golden Age]] Superman was removed from continuity. He also served as the main villain of ComicBook/PowerGirl's solo series.
* ComicBook/{{Deathstroke}} the Terminator started out as a ComicBook/TeenTitans rogue, turned towards antiheroism, and then became (after ''ComicBook/IdentityCrisis'') [[HeelFaceRevolvingDoor a sort of generic DC Universe villain]], being as much of a dick to as many superheroes as he could manage. He seems to have a hobby of [[PickOnSomeoneYourOwnSize harassing young heroes.]] He's never let go of his grudge against the Titans since he never completed his contract against them (a bit of a blow to his merc cred). He even went so far as to harass Damian Wayne, his ArchEnemy Comicbook/{{Nightwing}}'s (who was, for a while, Batman) protege. Additionally, he's also become a Franchise/{{Batman}} villain, often tangling with him many times and is considered an adversary to Batman almost as much as he is to the Titans.
* [[Characters/SupermanRoguesGalleryMToZ Superboy-Prime]] first appeared as a hero in the Franchise/{{Superman}} team-up series ''ComicBook/DCComicsPresents''. His FaceHeelTurn occurred in the CrisisCrossover '' Comicbook/InfiniteCrisis'', which put him up against many heroes of Franchise/TheDCU. He later faced Franchise/GreenLantern as an ally of the Sinestro Corps. After that, he fought the ComicBook/{{Legion of Super-Heroes}} during ''Comicbook/FinalCrisis''. He got to be the VillainProtagonist of his own EvilVersusEvil story during '' Comicbook/BlackestNight''.
* The Electrocutioner began as a one-shot Franchise/{{Batman}} villain before appearing in ''The Vigilante'' where he became the closest thing Vig had to an archenemy. Since the Vigilante's death, he has returned as a sporadic Batman foe.
* The Queen of Fables started out attacking the entire JLA, but now she is an enemy to both Franchise/WonderWoman and Franchise/{{Superman}}.
* [[DemonLordsAndArchdevils Blaze and Satanus]] began as demonic ''Franchise/{{Superman}}'' villains, but were later revealed to be the half-human offspring of the wizard Comicbook/{{Shazam}}. They've since become joint enemies of both the Superman and Marvel Families.
* Speaking of ''Comicbook/{{Shazam}}'' foes, Dr. Sivana used to be the [[InSeriesNickname Big Red Cheese's]] ArchEnemy, but eventually disappeared from Marvel stories to become the DC Universe's standard MadScientist, especially considering ComicBook/LexLuthor [[CutLexLuthorACheck is better known nowadays as a megacorp owner with his own research staff]]. He returns as a Shazam foe in the Comicbook/{{New 52}}'s ''Shazam'' series.
* Silver Banshee has historically been a Superman foe but in recent years she's been more associated with Comicbook/{{Supergirl}}. In the Comicbook/{{New 52}} she even became a (currently non-villainous) supporting cast member in Supergirl's comic.
* [[Characters/GLOtherVillains Hector Hammond]], a longtime enemy of Franchise/GreenLantern Hal Jordan, is recast as a Franchise/{{Superman}} villain in the ComicBook/{{New 52}}. As the Green Lanterns rarely deal with human, Earthbound threats these days, if Hammond were to see any use at all it would ''have'' to be fighting another hero.
* The Prankster, who exclusively fought Superman in the past, has become something like Comicbook/{{Nightwing}}'s archenemy in the New 52. He bears little resemblance to any previous incarnation of the character, however.
* When Nightwing moved to Bludhaven at the start of his solo title, the second Blockbuster was imported. A genius turned DumbMuscle in Batman, Blockbuster had just recently [[DealWithTheDevil made a deal with]] [[ComicBook/UnderworldUnleashed Neron]] to regain his genius while keeping his super strength and was now a Bludhaven crimelord.
* Major Force was originally ComicBook/CaptainAtom's arch-nemesis, but ever since the infamous [[StuffedIntoTheFridge fridge incident]], he's decidedly become a Franchise/GreenLantern villain.
* Black Mask zig-zagged this in an almost GenreSavvy way in the early 2000s. Previously a C-list Franchise/{{Batman}} villain, he TookALevelInBadass (and extreme sadism) to become ComicBook/{{Catwoman}}'s ArchEnemy. However, he then used that boost to effectively become top villain in Gotham for a time and an A-list member of Batman's Rogues Gallery. (This didn't stop Catwoman from being the one who eventually got to take him out, but that's because Batman has inhibitions about shooting people in the head.)
* ComicBook/{{Deadshot}} started off as a D-list Batman villain, became much better known as a member of the ComicBook/SuicideSquad. While Deadshot and Batman have often gone against each other since his elevation in status, he's not really considered to be a Batman villain in the same way characters like The Joker, Two-Face, Penguin, and the Riddler are, and more a general AntiHero[=/=]AntiVillain. He's also gone toe-to-toe with ComicBook/GreenArrow as well.
* Doctor Polaris (Neal Emerson) was a villain who went against ComicBook/GreenLantern and ComicBook/{{Superman}}. However, his successor Doctor Polaris II (John Nichol) instead became an antagonist to ComicBook/BlueBeetle (Jaime Reyes) after debuting in a Superman comic.
* Downplayed by Tobias Whale. Originally created as the ArchEnemy of ComicBook/BlackLightning, Whale moved to Gotham City and menaced Batman in the years when Black Lightning did not have his own book. Each time that Black Lightning gets his own title, however, Whale returns home to Metropolis to resume their grudge match.

[[folder:Comic Books - Marvel]]
* Wilson Fisk, ComicBook/TheKingpin, was introduced as a Franchise/SpiderMan villain, and though Spidey still fights him on occasion, you'd be hard-pressed to say that the character is not best known for being a nemesis of ComicBook/{{Daredevil}}, taking the place of the Owl (who is a lot harder to take seriously) among his enemies.
** Referenced (but not used directly) in ''WesternAnimation/SpiderManTheAnimatedSeries''; Fisk is the BigBad for much of the show, but in the episode where Daredevil does appear, it's made very clear that for him, ItsPersonal, while for Spidey, it's more of your standard hero/villain thing. [[WordOfGod Greg Weisman]] says they wanted Kingpin to be part of ''WesternAnimation/TheSpectacularSpiderMan'''s BigBadEnsemble, but couldn't because Sony only had the rights to ''Spider-Man'' characters and Marvel officially classifies him as a ''Daredevil'' villain now. (They wound up making Tombstone into an {{Expy}} of him, and left a few hints that he might be working for somebody else.).
** He ends up as the final BigBad in ''ComicBook/ThePunisherMAX'' (along with Bullseye and Elektra), a 'verse which has no superpowers.
* Other Spidey villains have been known to torment Daredevil from time to time, and vice-versa; the guys practically live next door to each other, so there's a ton of overlap (the Beetle being certainly the most recurring after Kingpin). Inverted with Mysterio who seems to have not so much transferred to Daredevil's gallery as branched out, becoming an enemy of both of them. Then he ended up [[ComicBook/SpiderMen switching SpiderMen]].
* The various Green Goblins were notable for being solely Spider-Man villains, never antagonizing other New York-based heroes as Doctor Octopus or Electro would. Since ''ComicBook/SecretInvasion'', however, ComicBook/NormanOsborn has been transformed into an over-riding BigBad of the Franchise/MarvelUniverse. After trying to take the Avengers again with another team of Comicbook/DarkAvengers and a H.A.M.M.E.R. made up of ComicBook/{{HYDRA}} and A.I.M. personnel, he has gone back to being a Spidey villain. [[spoiler:Firmly reestablished at the GrandFinale of ''Comicbook/SuperiorSpiderMan''.]]
* Since his resurrection Kraven the Hunter and his daughter Ana has been seen fighting other superheroes on a daily basis, mostly related to Spider-Man like ComicBook/{{Venom}}, [[ComicBook/SpiderWoman Spider-Girl]] or ComicBook/ScarletSpider, but Comicbook/BlackPanther and Comicbook/IncredibleHulk are also fair game. It helps Kraven seems to now live in the Savage Land, a place commonly visited by various superheroes.
* In ComicBook/AnyaCorazon's time as Spider-Girl, most of her antagonists were minor Spider-Man villains, like above mentioned Ana Kravinoff, Screwball or Hobgoblin.
* During Kaine's tenure as the ComicBook/ScarletSpider, he seems to have inherited the Jackal, the Lobo siblings, Shathra, Kraven and Ana Kravinoff from his 'brother', Spidey (though the Jackal is his creator and therefore a long standing part of his story), the Hand from Daredevil, Belladonna Boudreaux and the Assassins Guild from ComicBook/{{Gambit}}, ComicBook/{{Carnage}} from Spider-Man/Venom and evil MegaCorp Roxxon from Iron Man - though currently it seems to be a case of shared custody with Thor. Now, he's (reluctantly) one of the ComicBook/NewWarriors and as a result seems to have acquired the High Evolutionary and the Evolutionaries from the X-Men.
* Spidey inherited minor ComicBook/CaptainAmerica villain Vermin, JM [=DeMatteis=] basically pulling a Creator/ChrisClaremont.
* Shriek was introduced as an opponent for ComicBook/CloakAndDagger, but after ''ComicBook/MaximumCarnage'' she is more known as a Spider-Man villain and girlfriend of one of his most famous antagonists, Carnage. Speaking of Carnage, Marvel lately seems to be trying to invoke this and move him to fight other characters, like Kaine, [[ComicBook/{{Nova}} Sam Alexander]] or ComicBook/{{Deadpool}}.
* Fin Fang Foom was originally a general Franchise/MarvelUniverse monster. He has become an Comicbook/IronMan villain to the point that he has appeared in both ''WesternAnimation/IronMan'' and ''WesternAnimation/IronManArmoredAdventures'' cartoon series, was featured in the animated movie, and was considered as a foe for the live-action ''Film/IronMan'' movie... presumably without [[MonsterModesty the purple shorts]]. He still shows up in a FreezeFrameBonus, on a billboard.
* A minor IM villain named Scarecrow, a former acrobat, never battled IM after his first appearance; he bounced around quite a bit, battling the X-Men, Captain America and the Falcon, before becoming an enemy of Ghost Rider for quite a while; nowadays he's just puttering around.
* Black Knight was originally an enemy of ComicBook/AntMan and ComicBook/TheWasp, but ended up better known as an enemy of Comicbook/IronMan before being replaced by his heroic nephew. It got to the point where in ''WesternAnimation/IronManArmoredAdventures'', he's depicted exclusively as an Iron Man villain.
* ComicBook/{{Mephisto}} works well as a deliberate example: He was originally introduced in the ''ComicBook/SilverSurfer'' series, but has spent stints as an adversary of both Comicbook/TheMightyThor and Comicbook/GhostRider. To the modern reader, though, he's best known for his role in ''Comicbook/OneMoreDay''. Mephisto is best understood as a member of the RoguesGallery for the wider Marvel Universe, rather than any one hero, which is fitting as he is basically a stand-in for {{Satan}}. He has tangled with nearly every single major hero and several villains, and is a lot more personal for many.
* Rhino was introduced as a Franchise/SpiderMan foe but has spent a large chunk of his career battling the Hulk. At the very least, it's shared custody.
* Comicbook/{{Thanos}} first appeared as an enemy of Iron Man. This is because Thanos's creator, Jim Starlin, was offered to write an issue of Iron Man's comic and created Thanos to be the villain for that issue. When Starlin began writing Captain Marvel he reintroduced Thanos and the rest is history. Thanos is now linked with the ''ComicBook/SilverSurfer'' mythos, (Marvel Comics') [[ComicBook/CaptainMarVell Captain Marvel]], and Comicbook/AdamWarlock. Like Mephisto, he's now pretty much a general enemy of the entire lineup of "Cosmic Marvel" characters, if not the whole Marvelverse.
* Franchise/{{Wolverine}} started out as a foe of the Hulk, and fought several other heroes before becoming a hero himself primarily associated with the Franchise/XMen.
* Comicbook/{{Sabretooth}} was a foe of [[ComicBook/ImmortalIronFist Iron Fist]]. Incidentally, Sabretooth was originally intended to be Wolverine's father by creator John Byrne (he was based on Byrne's rejected design for Wolverine sans mask), but ended up getting dumped onto the Iron Fist title when Claremont and Cockrum weren't interested. Years later, Claremont decided to bring Sabretooth into the Wolverine fold.
* Lady Deathstrike first appeared fighting Daredevil before becoming integral to Wolverine's story.
* The first Silver Samurai, another character closely associated with Wolverine and the X-Men, also first appeared fighting Daredevil.
* Omega Red started off as an X-Men foe before focusing squarely on Wolverine. In the ComicBook/UltimateMarvel universe, Omega Red is primarily a foe of [[Comicbook/UltimateSpiderMan Peter Parker]] and his successor, [[AffirmativeActionLegacy Miles Morales]].
** Killer Shrike likewise underwent this, going from a foe to the Hulk and Iron Man in the classic Marvel Universe, to a foe of Spider-Man in the ultimate Universe.
* A temporary case - today, the Sandman is best-known as a Spider-Man villain, and he indeed made his first few appearances in ''The Amazing Spider-Man'', but during the '60s and '70s he ''mostly'' pestered the ComicBook/FantasticFour, either solo or as part of [[ThePsychoRangers the Frightful Four]]. In fact, the very first issue of ''Marvel Team-Up'' (a 1972 Christmas special) has Spidey claiming he only fought Sandman once, and the FF are the ''real'' "Sandman experts".
* The [[PsychoForHire contract killer]] Boomerang, who uses deadly gimmick boomerangs as his weapons, originally started out fighting [[Comicbook/IncredibleHulk the Hulk]], before he moved on to become a semi-regular Franchise/SpiderMan villain after writers realized that trick boomerangs versus the most powerful creature on Earth was a bit of a mismatch.
** Boomerang even appears in the Uncanny X-Men Nintendo game by LJN even though he's neither a X-Men enemy nor a mutant.
* Mister Hyde, a villain based on ''Literature/TheStrangeCaseOfDrJekyllAndMrHyde'', started out as a [[Comicbook/TheMightyThor Thor]] villain but would later move on to become a Comicbook/{{Daredevil}} regular, although he also took the time to mess with Franchise/SpiderMan, Comicbook/CaptainAmerica, Comicbook/GhostRider, and [[Comicbook/IncredibleHulk the Hulk]], finally settling in to become a regular foe of Cap, DD and the Big Green Machine. These days he seems to have moved to fighting teen heroes, considering his appearances in both ''ComicBook/YoungAvengers'' and ''ComicBook/AllNewGhostRider''.
* Cobra, Mister Hyde's sometime partner, also started out as a [[Comicbook/TheMightyThor Thor]] villain. He quickly figured out that his 'powers' of being double-jointed and crawling on his belly didn't make him capable of challenging the god of thunder and became a foe of Comicbook/{{Daredevil}} and Comicbook/CaptainAmerica.
* In the very early days of the Franchise/MarvelUniverse, the original Human Torch had his own rogues gallery as a solo hero. Two of his mainstays, the Wizard and the Trapster, would later become enemies of the ComicBook/FantasticFour, with the Wizard becoming an EvilCounterpart to Reed Richards and even forming his own EvilCounterpart team in the Frightful Four, of which the Trapster was a charter member. The Trapster and the Beetle, another long-standing enemy of the Torch, would also become recurring enemies of Franchise/SpiderMan. It's so pronounced that in both the ''Ultimate Spider-Man'' [[Comicbook/UltimateSpiderMan comic]] and [[WesternAnimation/UltimateSpiderMan TV show]], the Beetle is more or less treated as a straight-up Spidey villain. Though during the days he wore his first costume, he fought Daredevil more often, to completely abandon him with his upgrade, choosing Iron Man as a secondary nemesis. The Eel also originally debuted as a foe of the Human Torch before becoming a semi-regular Comicbook/{{Daredevil}} villain.
* Current Beetle debuted as one-time enemy of ComicBook/CaptainAmerica, but is now better known for her role in ''Comicbook/TheSuperiorFoesOfSpiderMan''.
* Many of the enemies the various members of Comicbook/TheAvengers had faced as solo heroes would later become enemies of the team as a whole, with characters like [[MadScientist Egghead]], an enemy of ComicBook/AntMan, a.k.a. Henry Pym, [[ThoseWackyNazis Baron Zemo]] (an enemy of Comicbook/CaptainAmerica), [[ManipulativeBastard the Norse trickster god Loki]], an enemy of Comicbook/TheMightyThor, and the Mandarin, the ArchEnemy of Comicbook/IronMan all becoming some of the Avengers' worst enemies. This would also get inverted. The first incarnation of the Masters of Evil featured the Black Knight as a foil for Wasp and Giant Man and Radioactive Man as the foil for Thor. Soon after, both became regular enemies of Comicbook/IronMan.
* ComicBook/TheEnchantress is normally an enemy of Thor and/or The Avengers (she's been known to tangle with the Scarlet Witch on occasion), but she has branched out- at one point she became the arch-enemy of ComicBook/{{Dazzler}}, of all people; recent events have had her teaming up with the new Lady Deathstrike and Typhoid Mary to counter the X-Men (Mary herself is normally an enemy of Daredevil)
* Comicbook/{{Mystique}} first appeared in ''Comicbook/MsMarvel'' and was originally slated to be her ArchEnemy. She's pretty much entirely an X-Villain nowadays, and her history with Ms. Marvel (such as [[StuffedIntoTheFridge killing her boyfriend]]) has been all but forgotten. She did return to torment Comicbook/MsMarvel in Carol's later series.
* Comicbook/{{Apocalypse}} first appeared in ''ComicBook/XFactor'' as the leader of the Alliance of Evil (a role, again, originally intended for the Owl) eventually becoming their BigBad, getting killed, and, upon resurrection, graduating to become one of the ComicBook/XMen's most powerful foes and being {{retcon}}ned as Comicbook/{{Cable}}'s archenemy. The former might not be quite enough to qualify as this trope since the incarnation of X-Factor that had Apocalypse as the BigBad consisted of the original five X-Men, making the whole thing X-Men in all but name to begin with. Cable, on the other hand, while very much an X-Men related character, has his own distinct rogues gallery that usually only overlaps with the X-Men during crossover events.
* Deathbird started as a ComicBook/MsMarvel villain before becoming a recurring foe of the ComicBook/XMen in general and Professor X's girlfriend Lilandra (her sister, as it turns out) in particular. Like Mystique above, this is a result of Creator/ChrisClaremont creating a villain for one book, then moving her to another when the first was canceled.
* Moonstone started off as a Hulk foe, but became more of a general Avengers villain after joining the Masters of Evil. Then during Comicbook/DarkReign, she was positioned as Ms. Marvel's EvilCounterpart.
* June Covington, aka "Toxic Doxie", started off as one of Norman Osborn's allies from his limited series. She went on to menace the Comicbook/NewAvengers as the ComicBook/DarkAvengers' impostor ComicBook/ScarletWitch, but has since settled on terrorizing [[ComicBook/MsMarvel Captain Marvel]]. This is because June was originally created by Creator/KellySueDeconnick, who then brought the character over to the ''Captain Marvel'' book once she started writing it.
* Arcade debuted in the pages of ''Marvel Team-Up'', a title that had Spider-Man teaming up with other Marvel heroes, but these days is better known as an ComicBook/XMen villain. Arcade then moved on to be the villain for young Marvel superheroes, since the X-Men got more savvy and DarkerAndEdgier. He trapped the Comicbook/AvengersAcademy kids and the [[UsefulNotes/TheModernAgeOfComicBooks Modern Age]] Young Allies in Murderworld, and is the main villain in ''Comicbook/AvengersArena'', a ''Literature/BattleRoyale'' type title starring many Marvel teens.
--> '''Young!Cyclops:''' Uh, what're you guys doing here?
--> '''Deadpool:''' Hi-ya, Mini-Cyclops! We got a present for you!
--> '''Spider-Man:''' We know he's not a mutant, but even though I fought him first he's somehow become part of the whole X-Men deal. Which makes him your deal.
* The demon Blackheart debuted in Daredevil, though now spends most of his time messing with Comicbook/GhostRider, even appearing as the villain in [[Film/GhostRider the movie adaptation]]. He also shows up in ComicBook/XMen from time to time (amongst others), even at one point serving as the Black King of the Hellfire Club.
* The Purple Man originated as a Daredevil villain, but has since become the ArchEnemy of ComicBook/JessicaJones.
* Minor-league Comicbook/IronMan villains [[AnIcePerson Blizzard]] and [[PlayingWithFire Firebrand]] started out fighting Shellhead, but eventually transitioned to fighting street-level heroes like Franchise/SpiderMan after Tony Stark's equipment began to completely outclass theirs. And Shellhead's greatest foe, The Mandarin, took time out- primarily in the 60s and 70s- to deal with other characters. The very first ''Avengers'' annual had Amora and Skurge, Living Laser, the original Power Man and the Swordsman working for him to distract the Avengers from his plan of broadcasting worldwide hate-rays. The late 60s had him clash with the Hulk a few times (one time getting Nick Fury involved, another involving the Sandman- normally a Spider-Man foe), another time he kidnapped a peacemaker who was rescued by Captain America, and still another time saw him encounter the Inhumans in an attempt to gain a Makulan artifact. Since then though, he's been sticking with IM.
* Moses Magnum started out fighting Spider-Man and Comicbook/ThePunisher, but seems to have eventually settled on antagonizing Comicbook/BlackPanther. Thematically, Magnum and T'Challa are a perfect fit.
* Klaw is a Black Panther villain, but he's also a fairly prominent enemy of the Fantastic Four, and has menaced Daredevil a number of times as well.
* Bolivar Trask is most associated with the ComicBook/XMen in mainstream Marvel continuity, but in the [[ComicBook/UltimateMarvel Ultimate Universe]] he became integrated into Comicbook/UltimateSpiderMan's mythos, eventually becoming the BigBad of [[VideoGame/UltimateSpiderMan the video game adaptation]].
* The Absorbing Man, who was able to [[PowerCopying mimic and absorb the physical properties of anything he touched]], started out as a recurring enemy of Comicbook/TheMightyThor and remains a charter member of Thor's RoguesGallery. However, he's also tangled with the Comicbook/IncredibleHulk enough times that it's arguably shared custody.
* Comicbook/DoctorDoom was created to be the main nemesis of the ComicBook/FantasticFour. While he still maintains that role to the present day, he has since become one of the overall Big Bads of the Marvel Universe and has fought pretty much every single Marvel hero. Most prevalent are his tussles with Comicbook/BlackPanther, which makes sense because BP was originally introduced as a Fantastic Four ally and a GoodCounterpart to Doom in the first place. Doom is also known for his roles in classic ComicBook/IronMan stories and the graphic novel ''Triumph & Torment'' where he meets ComicBook/DoctorStrange. Even other villains are not safe from Doom. He will gladly co-op with the heroes if he feels it serves his interests (of course, [[ChronicBackstabbingDisorder once the interests are served...]]) This is so pronounced that it's even reflected in marketing. For instance, Creator/{{Hasbro}}'s "Titan Hero" action figure line usually references the installment each hero or villain comes from (''Film/IronMan3'', ''WesternAnimation/AvengersAssemble'', ''Film/ThorTheDarkWorld'', ''Film/GuardiansOfTheGalaxy'', etc.), but the packaging for the Doctor Doom figure contains no indication that he belongs to the Fantastic Four franchise.
* Comicbook/{{MODOK}} was originally created as a foe for ComicBook/CaptainAmerica. However, in his role as leader of AIM, he's increasingly become an antagonist of Comicbook/IronMan. And then the Comicbook/IncredibleHulk, as he created Comicbook/RedHulk.
* ''ComicBook/{{Annihilation}}'' has the ComicBook/FantasticFour's long-time foe Annihilus launching a devastating attack on the universe, uniting cosmic heroes like Comicbook/{{Nova}} and the ComicBook/SilverSurfer against him. Even through Annihilus returned a few years later to fight the first family again, he is now generally considered a threat to the entire universe.
* ''Annihilation Conquest'' does a similar thing - Avengers villain Comicbook/{{Ultron}} takes control over the Phalanx, a race mostly known for their fights with the X-Men, as well as a few lesser-known villains like the Avengers' enemy Ultra-Adaptoid or the Fantastic Four's foe Blastaar, and then goes against cosmic heroes. Ultron later returned to fighting the Avengers, though.
* In a similar vein, ''ComicBook/WarOfKings'' is driven by conflict between the Kree Empire, ruled by Comicbook/TheInhumans, and the Shi'Ar Empire, ruled by X-Men foe Vulcan. Time will show which group Vulcan will stick to antagonizing.
* [[EldritchAbomination Shuma-Gorath]] debuted in Marvel's ''ComicBook/ConanTheBarbarian'' comics, but has been better known for his classic fights against Comicbook/DoctorStrange. He more or less lost his association with the good doctor when he [[UnexpectedCharacter unexpectedly appeared in]] ''VideoGame/MarvelSuperHeroes'', [[AdaptedOut where Strange was absent]]. ''ComicBook/TheThanosImperative'' and a few other appearances helped him get upgraded to universal threat, like Mephisto or Thanos. Similarly, Nightmare started as a ComicBook/DoctorStrange foe, but has since then fought with pretty much everybody.
* Demogorge the God Eater and Amatsu Mikaboshi all debuted as antagonists of Comicbook/TheMightyThor. To modern readers they are probably known as enemies and [[EnemyMine occasional allies]] of Comicbook/TheIncredibleHercules.
* Comicbook/ThePunisher has few reoccurring villains due to his deadly nature but one of his few villains, Jigsaw, started off as a Spider-Man villain, although his introductory story did involve Punisher as well. Punisher himself was a Spider-Man villain, however he was more of an antagonistic AntiHero and now has his own titles where he scuffles with every street level hero when he's not massacring normal criminals.
* [[LegacyCharacter Jimmy Natale's Vulture]] started off as a Spider-Man villain before moving over to the Punisher's corner of the Marvel U during Creator/GregRucka's run. [[KilledOffForReal He didn't survive the trip]].
* The crossover event "Acts of Vengeance" best describes this trope. It involves the very idea of [[OpponentSwitch a wide array of super-villains facing heroes they had never met (or at least were villains that weren't part of the heroes' regular gallery)]]. Such examples were Comicbook/AlphaFlight fighting Scorpion, Spider-Man (who was granted cosmic powers at the time) fought Goliath, The Brothers Grimm, Titania, Magneto, Graviton, Trapster, Dragon-Man, and the Tri-Sentinel. Daredevil fought Ultron, Thor fought Juggernaut, Mandarin appears in the X-Men issues, and Rusty and Skids of the ComicBook/NewMutants battle the Vulture. Even Magneto went against the ComicBook/RedSkull for very obvious reasons.
* Marv Wolfman originally created ComicBook/BlackCat as an enemy for ComicBook/SpiderWoman; however, Wolfman was transferred to ''Spider-Man'' before he could introduce her, and he brought her with him.
* Thanks to sharing continuity, Marvel's [[ComicBook/GIJoeARealAmericanHeroMarvel G.I. Joe]] series had an entire story arc with [[ComicBook/TheTransformers Megatron]] as the antagonist.
* An {{inver|tedTrope}}sion happened to The Pride - they were always antagonists of the ''ComicBook/{{Runaways}}'' and it would be pretty hard to introduce them fighting any other superheroes while their entire point was they kept their operations under their radar. That was the case until the creation of [[Comicbook/NewAvengers Avengers Illuminati]] who were also working in secret from the entire Marvel superheroic community. So of course there exist comics that revealed the two groups clashed back in the days when the Runaways were still only kids.
* After Doctor Sun was defeated in ''Comicbook/TheTombOfDracula'' by the joined forces of Dracula and the vampire hunters, he went to antagonize Comicbook/{{Nova}} and Comicbook/FantasticFour.
* Dracula himself also qualifies, though he didn't start out as anyone's rogue and happened to fight any superhero who crossed his way like Thor, Silver Surfer or Dr. Strange. With that said, he went on to became a recurring antagonist to {{ComicBook/Blade}} (who, ironically, starred in Dracula's own series and went to become hugely popular afterwards) and regularly clashed with the X-Men-related characters more than with any other hero, such as Storm, Old Man Logan and Deadpool. It was revealed that even X-Men's BigBad {{ComicBook/Apocalypse}} was Dracula's ArchEnemy at one point.
* MadScientist Dr. Bong began life as the foe of ComicBook/HowardTheDuck, but recently he seems to have largely migrated over to being part of Deadpool's supporting cast. Deadpool has also tangled with [[{{ComicBook/Daredevil}} Bullseye]] enough as a FriendlyEnemy that it's practically shared custody.
* The Crime Master and Jack O' Lantern were traditionally Spider-Man villains, but after [[{{ComicBook/Venom}} Agent Venom/Flash Thompson]] got his own book they made the jump with him and settled down as his archenemies.
* Black Tarantula debuted as a Spider-Man villain, but most of the modern readers are probably more familiar with him undergoing HeelFaceTurn and becoming a supporting character for Daredevil, or with [[LegacyCharacter his son taking the name]] and antagonising ComicBook/SpiderGirl in her universe.
* [[http://brevoortformspring.tumblr.com/post/120237862353/no-appearances-such-as-what-you-suggest-would This is actually part of the Marvel creative process]] - villains are catalogued by the hero they fight with and if you have to use any, you need to ask the editor overseeing that character at the moment. But if you write a very good story with the villain or use him a lot, he might be moved. For example, when ''ComicBook/UncannyAvengers'' was heavily using the Red Skull, writers had to ask that book's editor for permission to use him, instead of the ''Captain America'' editor.
* Samuel Saxon started out as a Daredevil villain, both under his nickname "Starr" Saxon as well as the second Mister Fear. However, after being killed off in a Daredevil issue and receiving an EmergencyTransformation, he's pretty much exclusively been a Captain America villain as the android Machinesmith.
* While ComicBook/{{Magneto}} is primarily known for his [[HeelFaceRevolvingDoor complicated]] relationship with the X-Men, he has tangled with all of Marvel's major heroes as well, particularly the Avengers, Fantastic Four, Thor, and Spider-Man.
* With Peter Parker becoming head of Parker Industries during the ComicBook/AllNewAllDifferentMarvel event and Spider-Man dealing with bigger foes, his previous streel-level Rogues Gallery is now being handled by Comicbook/MilesMorales, Spider-Woman, and Comicbook/{{Silk}}. Both Silk and Miles have dealt with Black Cat, and Spider-Woman has gone up against Hobgoblin.
* Speaking of Spider-Woman, Morgan Le Fay used to be her arch-nemesis, but now she's a general Marvel Universe villain, mainly tangling with the Avengers. In the [[ComicBook/SpiderWoman2014 2014 volume]], Spider-Woman has mainly been fighting C-list/D-List villains such as Tiger Shark (a traditional ComicBook/SubMariner villain), the Sandman (A Comicbook/SpiderMan villain), and the Blizzard (traditionally an Comicbook/IronMan villain).
* Roxxon Energy, the evil MegaCorp are mostly known for pestering Iron Man, but under new CEO Dario Agger (who's also a Minotaur), they've mainly been an enemy to both Thor and [[Comicbook/Thor2014 Lady Thor]].
* The general public now knows Ronan the Accuser as the villain of the 2014 ''Film/GuardiansOfTheGalaxy'' film, but he actually debuted as a ''ComicBook/FantasticFour'' antagonist, and is now in fact [[HeelFaceTurn not much of a villain at all in the comics]] (to the point of ''teaming up'' with the Guardians in one of his most recent appearances)
* Following the disbanding of the Fantastic Four after ''ComicBook/SecretWars2015'' many of their enemies have gone on to face other heroes. Terrax went up against the X-Men.
* Comicbook/KateBishop/Hawkeye has seen longtime Iron Man foe Madame Masque become a recurring nemesis, first fighting her during her solo arc the 2015 Hawkeye run, then fighting her again in her solo series debut.

[[folder:Comic Books - Other]]
* In ''Comicbook/ArchieComicsSonicTheHedgehog'' series, the Dark Legion - a group of villainous Echidnas - was originally created to serve as enemies of Knuckles, acting as the central antagonists of his spin-off. However, after the "Enerjak Reborn" arc in the main series (several years after the ''Knuckles'' spin-off was cancelled), the Legion allied with Sonic's ArchEnemy Dr. Eggman and began serving as his personal army. Therefore, they can be seen as much Sonic's enemies as Knuckles' these days.
* Done intentionally in ''[[Comicbook/{{Fables}} The Great Fables Crossover]]'' in which Snow White and Bigby Wolf deal with Literals, antagonists of ''Fables'' spin-off series ''Jack of Fables'', while Jack, who clashed with them all the time until this point, doesn't move a finger to help.
* Happens in the ComicBook/DisneyMouseAndDuckComics:
** [[MadScientist Emil Eagle]] originally was made up to give Gyro Gearloose a criminal rival, but he later became a recurring character in Mickey Mouse comics by Paul Murry et al., mostly to explain how people like [[ThoseTwoBadGuys Idget the Midget and Dangerous Dan McBoo]] or [[PsychoForHire Pete]] could have sophisticated plans or super-science equipment; recent Italian stories put him as Super Goof's opponent in a relationship akin to Franchise/{{Superman}} and ComicBook/LexLuthor.
** The Beagle Boys and John Rockerduck are usually Scrooge's villains, but they also have to deal with Paperinik (Donald's superhero identity), and the Beagle Boys are also enemies of the Red Bat (''Fethry''[='=]s superhero identity).
** The Phantom Blot is mainly Mickey's foe, but has scuffled with others from time to time.
** ''ComicBook/{{Ultraheroes}}'' has this in spades, with the heroes mostly 'borrowing' their rivals from Paperinik. The main exception is Paperinika (Daisy's super hero alter ego), as she already [[ItsPersonal had it personal with Sapphire]].
** ''ComicBook/DarkwingDuck'' features several Duck comics and Duck Tales villains such as Phantom Blot, John D. Rockerduck and Magica de Spell.
* In the past, it was common for ''Creator/HannaBarbera'' TV shows to get {{Comic Book Adaptation}}s. Many just retold stories straight from the episodes. But one story chose to feature Reducto, an antagonist of one episode of ''WesternAnimation/{{Birdman}}'' (and later a recurring character on ''WesternAnimation/HarveyBirdmanAttorneyAtLaw''), fight ''WesternAnimation/TheHerculoids''.

[[folder:Films -- Live-Action]]
* The {{Kaiju}} Baragon was originally the enemy of a giant version of FrankensteinsMonster in ''Film/FrankensteinConquersTheWorld''. However, Baragon eventually became part of Franchise/{{Godzilla}}'s RoguesGallery thanks to video-games, action figures, and the films ''Film/DestroyAllMonsters'' and ''Film/GodzillaMothraKingGhidorahGiantMonstersAllOutAttack''.
* Both Franchise/{{Alien}} and Franchise/{{Predator}} started as antagonists in their own movies. Today, the two races are more known for [[Franchise/AlienVsPredator fighting each other]].
* ''Franchise/MarvelCinematicUniverse'':
** Thanos is usually associated with [[ComicBook/CaptainMarVell Captain Marvel]] and the ComicBook/SilverSurfer, but first appears in the MCU as the mastermind behind the events of ''Film/{{The Avengers|2012}}''.
** Ego the Living Planet, normally a foe of Thor and the Fantastic Four (as well as occasional run-ins with the Silver Surfer and even a skirmish with ComicBook/RomSpaceKnight), is the main villain of ''Film/GuardiansOfTheGalaxyVol2'' [[spoiler:and is Peter/Star-Lord's father]].
** ''Film/AntManAndTheWasp'' features both the Ghost and Sonny Burch as villains. Both of them were ComicBook/IronMan villains in the comics.
** Played with by ''Film/SpiderManHomecoming''. While Vulture ''is'' a Spider-Man nemesis in the comics, his main beef in the movie is with Tony Stark, with Spidey just being the guy who keeps getting in his way.
* Viper started off as a Comicbook/CaptainAmerica foe and is usually an enemy of Comicbook/NickFury and ComicBook/{{SHIELD}} as well (to the point that she's now known as ComicBook/MadameHydra). Despite this, she is one of the antagonists in ''Film/TheWolverine''. Understandable since despite her connections to Captain America and S.H.I.E.L.D., she has appeared in several notable Wolverine storylines.
* ''Film/StarTrekIntoDarkness'': [[spoiler: Khan]], in a change up from the original chain of events, ends up with [[spoiler: Spock]] as his primary adversary in this film. He lacks the grudge that defined him [[spoiler: from being marooned by Kirk in the prime-timeline, and ends up spending more time in an EnemyMine with Kirk than he does fighting him, since without that glaring flaw of ItsPersonal with Kirk, he can make wiser decisions around him]]. [[spoiler: Kirk]] still seems to gain his respect as a WorthyOpponent with a similar care for his crew, but this movie might be called [[spoiler: Wrath of Spock once Kirk's {{Almost Dead|Guy}}]].
* Thulsa Doom originated in a ''Literature/{{Kull}}'' story, and most of the heroic characters in ''Film/ConanTheBarbarian1982'' would probably have been much happier people if he'd stayed there.
* Akivasha in ''Film/KullTheConqueror'' was originally a minor Conan antagonist that gets promoted to BigBad here, ironically enough bringing this trope full circle.

* Randall Flagg was introduced as the enemy of Mother Abigail in Stephen King's ''Literature/TheStand'', amassing an army on Earth to attack and destroy her more peaceful followers. However, Flagg is ''far'' more well-known as the nemesis of Roland Deschain, the dimension-hopping hero of King's epic fantasy saga, ''Literature/TheDarkTower'', and acts as the main villain of that series, even though there's an even greater evil [[TheManBehindTheMan behind him]].

[[folder:Live Action TV]]
* ''Series/{{Batman}}'' had the Comicbook/GreenArrow foe Clock King acting as a member of Batman's rogues gallery. Similarly, minor Superman villain Puzzler was once used instead of The Riddler for a two part episode, due to a contract dispute with Frank Gorshin. The Archer also originated as a minor Superman villain in the comics before appearing on this show as a Batman villain.
* Darla was introduced in ''Series/BuffyTheVampireSlayer'' as a DarkActionGirl Female Vampire Antagonist for Buffy, though was killed off soon after her debut. However, she was revived as a much more potent and ongoing adversary for Series/{{Angel}} in his eponymous spinoff; even in Buffy they had a much more significant connection, as Darla was established as both his vampiric sire and former lover.
* On ''Series/DoctorWho'', the Slitheen family started out as briefly recurring antagonists of the Ninth Doctor, then disappeared from the main series and started showing up frequently on ''Series/TheSarahJaneAdventures''.
* The Cardassians began as villains of the week on ''Series/StarTrekTheNextGeneration'' but ended up with much greater plot significance on ''[[Series/StarTrekDeepSpaceNine Deep Space Nine]].''
** To a somewhat lesser extent, the same thing could also be said of the Romulans being more associated with ''[[Series/StarTrekTheNextGeneration The Next Generation]]'' than with ''TOS''.
** The Borg are a {{subver|tedTrope}}sion of sorts. After twenty (of which four were two-parters) appearances on ''Voyager'', plus a Borg character joining Voyager's main cast for the last four seasons, one might have expected them to be more associated with that series than with ''TNG'', which only featured them in four episodes (of which two were two-parters) plus ''First Contact''. Despite this, in popular consciousness, the Borg are still considered Picard's nemesis.
* The Comicbook/GreenArrow adaptation ''Series/{{Arrow}}'' has Comicbook/{{Deadshot}} and Comicbook/{{Deathstroke}} as recurring foes. Deadshot is a Batman villain usually associated with the Comicbook/SuicideSquad and ComicBook/SecretSix, while Deathstroke is traditionally an enemy of the Comicbook/TeenTitans. JustifiedTrope in these cases, as Deathstroke and Green Arrow had a long-standing rivalry in the comics after the events of ''ComicBook/IdentityCrisis'', and Deadshot has encountered Green Arrow many times in the comics (the two even becoming sorta-friends in Deadshot's second miniseries that introduced his daughter Zoe). Both have largely became standard DCU villains as it is, so they are, technically, up for grabs
** Along those same lines, ''Series/{{Smallville}}'' had Deathstroke show up as a recurring foe despite having little if any connection to the Franchise/{{Superman}} mythos, while Deadshot appeared as part of the Suicide Squad in the last season of the show. Although ''Smallville'' is [[AlreadyMetEveryone pretty infamous about it]]. In an inverse of the ''Batman'' example from above, ''Arrow'' also uses Firefly and Dollmaker (both of whom are Batman villains).
** Arrow's second season continues the trend, using (among others) Solomon Grundy, Nyssa al Ghul, and Brother Blood.
** Season three has introduced ComicBook/RasAlGhul, justified through his canonical connection to Merlyn (but with plenty of references to Batman).
** Season four has the main antagonist being the head of HIVE, an organization which was historically enemies of the ComicBook/TeenTitans, and introduces Batman villain ComicBook/{{Anarky}}.
** Season five features the traditional Batman villain Prometheus, having received a wardrobe change meant to evoke Oliver's original suit from Season One. While WordOfGod says that he is NOT the same character, the show's Prometheus obviously has the same modus operandi as the original comic book character.
** Milo Armitage, who was initially introduced in Season 2 before being revealed as a member of HIVE, was a foe of Connor Hawke's (in part because he was Sandra Hawke's abusive husband). Here, he's a foe of Oliver.
* ''Series/TheFlash2014'' has some villain-swapping amongst the various Flashes.
** The BigBad of Season 2 is Hunter Zolomon/Zoom, the ArchEnemy of Wally West in the comics. Since Wally has yet to gain his speed, Zoom spends the series fighting Barry Allen.
** The Rival, traditionally an enemey of Jay Garrick, fights Barry and Wally as a StarterVillain in Season 3.
** Savitar singles out Barry as his archfoe, while his comic counterpart was introduced in the Wally West Era. It gets more complicated when its revealed that [[spoiler: "Savitar" is really the show's version of [[FutureMeScaresMe The Future Flash]], who actually did focus exclusively on Barry in the New 52 comics]].
* ''Series/OnceUponATime'' puts either Rumplestiltskin or the queen from Snow White in ''everything''. Rumple has been Cinderella's fairy godmother, Beauty's Beast, and Captain Hook's crocodile, while Regina has been the Little Mermaid's Sea Witch and the wicked stepmother who abandoned Hansel and Gretel (though not actually their stepmother, she was still responsible for the events.) Then there's the spin-off, ''Series/OnceUponATimeInWonderland'', in which Alice's main antagonist is [[Disney/{{Aladdin}} Jafar.]]
* ''Franchise/MarvelCinematicUniverse'':
** ''Series/AgentsOfSHIELD'' makes liberal use of this trope since most of the main characters are {{Canon Foreigner}}s, and thus have no existing rogues from the comics. You have enemies of Iron Man (Blizzard, [[LegacyCharacter (a)]] Whiplash), Thor (the Absorbing Man, Lorelei), Captain America (the Watchdogs), the Hulk (General Talbot), the Avengers (Graviton), and even Comicbook/{{Nova}} (Blackout). Special mention goes to [[spoiler:Mister Hyde]], who as noted above has bounced around between multiple superheroes in the comics but is here made specifically a S.H.I.E.L.D. villain by capitalizing on the development in the comics that [[ComicBook/DaisyJohnson his daughter]] is a S.H.I.E.L.D. agent. Lash and Eli Morrow could also qualify, respectively being an ''[[ComicBook/TheInhumans Inhumans]]'' and an ''ComicBook/AllNewGhostRider'' villain transplanted to S.H.I.E.L.D., but then again Inhumans and Ghost Rider himself were used in the show so they fit.
** ''Series/AgentCarter'' likewise stars someone who in the comics was merely a supporting character and had no specific enemies of her own. The show's villains were [[spoiler:Dr. Faustus]] and the Secret Empire (renamed the Council of Nine in this show) from ''Captain America'', Madame Masque from ''Iron Man'', and [[spoiler:an evil ComicBook/BlackWidow, who is technically a CanonForeigner but draws on the heroic ComicBook/BlackWidow's backstory that she wasn't the first such Soviet agent]].
** ''Series/JessicaJones2015'' features Kilgrave as its main antagonist. Kilgrave started as a Daredevil villain. It becomes ironic when Jessica meets Claire Temple and she offers to solicit Matt to help out in Jessica's crusade against Kilgrave. She turns down the offer because she doesn't want him enslaved as well, but in the comics, he's able to resist Kilgrave's commands due to his DisabilitySuperpower. Will Simpson, another Daredevil villain, also appears as an enemy of Jessica's, albeit with a very different background and origin.
** ''Series/IronFist2017'' features the Hand as main antagonists, who are usually Daredevil foes just like Kilgrave, but the difference is that Matt did actually fight them in season 2 of ''Series/Daredevil2015'' beforehand. Not only does Danny square off against the Hand in the show, but it turns out the Hand are the sworn enemies of K'un L'un denizens and it's the Iron Fist's duty to oppose them.
* In ''Series/{{Supergirl 2015}}'', most of the bad guys she fights are actually Superman villains in the comics: Toyman, Livewire, Master Jailer, etc (Silver Banshee, though originally a Superman foe, had already transitioned into mostly a Supergirl rogue - [[Comicbook/{{New 52}} or friend]] - in the comics a few years before the start of the show.) However, this trope is only directly invoked when she fights Reactron, whom Clark recognizes as one of his more powerful enemies. Ironically, Reactron in the comics is primarily a Supergirl villain. Season two features a crossover with ''Series/TheFlash2014'' where the heroes fight TheMusicMeister, who was a Franchise/{{Batman}} villain in [[WesternAnimation/BatmanTheBraveAndTheBold his debut]].
* ''Series/HerculesTheLegendaryJourneys'' and its spin off ''Series/XenaWarriorPrincess'':
** Ares, the God of War, was occasionally fought by Hercules in its first season, but he became a regular antagonist to Xena. Hercules still fought Ares from time to time, specially after Season 3 where was cast by Kevin Smith, but he is much more important to Xena, not just as an enemy, but also as supporting character.
** In regards to the original myths, the Minotaur was slain by the hero Theseus, while he is fought by Hercules in the TV-movie ''The Maze of the Minotaur'', where its revealed he is also his [[CainAndAbel half-brother]] and Theseus is AdaptedOut completely.
** [[OurVampiresAreDifferent Bacchus]] first appeared on ''Xena'' and was killed off by the end of his episode, but he would appear in subsequent appearances in ''Series/YoungHercules'', a prequel to ''Legendary Journeys'' where he fought against Hercules in his early career more than once.
* ''Series/Titans2018'' has the Acolyte as the main villain of the first season, who was the BigBad to ComicBook/YoungJustice, the team that was the SpiritualSuccessor to the Titans in the comics.

[[folder:Professional Wrestling]]
* The main purpose of Black Tiger is to oppose Tiger Mask. From the very beginning of the {{defictionalization}} of the feud though, Black Tiger also opposed, and ultimately defeated El Gran Hamada before [[Wrestling/SatoruSayama "first" Tiger Mask]] avenged him. Even though Tiger Mask would ultimately defeat Black Tiger, Tiger Mask was the one to "lose" his mask when it was bought from Wrestling/{{New Japan|ProWrestling}} by Wrestling/{{All Japan|ProWrestling}}. AJPW were uninterested in pitting [[Wrestling/MitsuharuMisawa Tiger Mask II]] against his traditional nemesis but Black Tiger simply changed targets again, going after The Cobra.
* Besides the inevitable clash with his [[LegacyCharacter contemporary]] Tiger Mask, [[Wrestling/EddieGuerrero Black Tiger II]] was also known for harassing [[Wrestling/JushinThunderLiger Jushin Liger ]]and [[Wrestling/ChrisBenoit Pegasus Kid]].
* Black Tiger III's demise came not at the hands of a Tiger Mask, but at [[Wrestling/LaParka L.A. Par-K]]'s at a Wrestling/{{CMLL}} event.
* While Black Tiger IV was eventually unmasked by Tiger Mask IV, he did spend time going after Wrestling/{{N|ationalWrestlingAlliance}}WA World Junior Heavyweight Champion Jason Rumble, if only to better position himself in later offenses on Tiger Mask.
* Two years after Tiger Mask IV unmasked Black Tiger V, Black Tiger V reappeared in [[Wrestling/DragonGate Toryumon Mexico]] to oppose Wrestling/UltimoDragon.[[/folder]]

[[folder:Video Games]]
* While the ''VideoGame/SuperRobotWars'' series does, of necessity, involve various HumongousMecha fighting enemies from different shows, it can sometimes veer into this territory with especially strong enmities developing between characters of different series, especially in regards to OriginalGeneration characters. The best example would probably be from ''VideoGame/SuperRobotWarsOriginalGeneration 2'', where Axel Almer of '' VideoGame/SuperRobotWarsAdvance'' fame becomes the arch nemesis of the [[VideoGame/SuperRobotWarsCompact2 Impact series]]' Kyosuke Nanbu.
* Seifer of ''VideoGame/FinalFantasyVIII'', known for being Squall's RivalTurnedEvil plays TheRival to Roxas, a member of MassiveMultiplayerCrossover series ''Franchise/KingdomHearts''' OriginalGeneration, and has nothing to do with Squall.
* In ''VideoGame/SuperSmashBros'', Wario, Bowser and Ganondorf become a general BigBadEnsemble of the Nintendo universe, with only the former interacting at all with a character he was initially associated with. Master Hand of the game's OriginalGeneration became a Kirby mini-boss and then teamed up with Crazy Hand to be a boss proper in ''VideoGame/KirbyAndTheAmazingMirror''. In this case, it's because both games were made by Hal Laboratory.
* ''Franchise/SuperMarioBros''
** While they still are sometimes enemies of Mario, Shy Guys, who originated in ''VideoGame/SuperMarioBros2'', are now a standard enemy of the ''VideoGame/YoshisIsland'' series, while Yoshi didn't even exist yet when ''Super Mario Bros. 2'' came out.
** In reverse, Kamek, Baby Bowser's caretaker from the Yoshi games, has made frequent appearances in the mainline games and [=RPG=] spin-offs to the point of being (adult) Bowser's [[TheDragon right-hand man]] in several games.
** King Boo was formally introduced as Luigi's archnemesis in the ''VideoGame/LuigisMansion'' games, but he still makes appearances in the Mario platformers and sports spin-offs every now and then (although he looks [[YouDontLookLikeYou different in those]]), so he doesn't end up being much different from the other several {{King Mook}}s that Mario himself faces in the series.
* Chaos from ''VideoGame/FinalFantasyI'' is actually the BigBad of the entire ''Franchise/FinalFantasy'' [[TheMultiverse Multiverse]] as of ''VideoGame/DissidiaFinalFantasy''.
** Also happened before that as well, since [[spoiler:he is actually Garland's OneWingedAngel incarnation, and Garland is TheManBehindTheMan in ''VideoGame/FinalFantasyIX'', though it's ambiguous as to whether they're the same character]].
** Gilgamesh was TheDragon in ''VideoGame/FinalFantasyV'', but is now [[WalkingTheEarth Walking The Multi Verse]] as a BonusBoss.
* In ''X-Men: The Official Game'' (the prequel to ''Film/XMenTheLastStand''), the HYDRA organization is depicted as being the true creators of Master Mold and the Sentinels, the mutant-hunting {{Killer Robot}}s from the X-Men books. In the actual comics, HYDRA is traditionally depicted as a threat to ComicBook/CaptainAmerica and Comicbook/TheAvengers.
* Merlock, the BigBad of the ''WesternAnimation/DuckTales'' movie ''WesternAnimation/DuckTalesTheMovieTreasureOfTheLostLamp'', was featured in two video games, both of which starred protagonists other than Scrooge [=McDuck=] and his three grandnephews Huey, Dewey, and Louie. His first video game appearance was as a boss in ''Legends of Illusion'', which starred Mickey Mouse. His second appearance in a video game was as the main antagonist and final boss in ''VideoGame/DonaldDuckGoinQuackers'', where he menaced Donald Duck by kidnapping Daisy.
* This is one of the plot points in ''VideoGame/LEGODimensions''- thanks to [[BigBad Lord Vortech's]] meddling around with rifts in his own attempt to conquer the multiverse, enemies from various franchises have been taken to different settings. [[Franchise/TheLordOfTheRings Sauron]] has landed his tower in the middle of [[Franchise/{{Superman}} Metropolis]], [[WesternAnimation/TheLEGOMovie Lord Business]] is overseeing the invasion of [[WesternAnimation/TheSimpsons Springfield]], and Vortech himself shows up to challenge the heroes in [[Franchise/BackToTheFuture 1885 Hill Valley]].
* In the ''Franchise/KingdomHearts'' series, most of the Disney villains stick to their own worlds and antagonizing their own heroes, even in the first game, the only one to feature a team of villains sharing a single headquarters. Maleficent, however, is promoted to a general antagonist, the only villain from a Disney movie to appear in multiple worlds and have an interest in the series' overarching plot. Not until ''VideoGame/KingdomHeartsBirthBySleep'' did we see her in the actual ''Disney/SleepingBeauty'' world, clashing with Prince Phillip and the three good fairies, and even then she made it clear that she had bigger ambitions. Hades counts as well, as he's gone up against multiple heroes from the ''Franchise/FinalFantasy'' series, if only because such heroes keep finding themselves in the ''Disney/{{Hercules}}'' world for some reason.

[[folder:Web Original]]
* The Angry German Kid originally started out as a Website/YouTube Meme, but eventually became one of the main memes at Nico Douga, with the new moniker of Keyboard Crusher.
* In the ''Roleplay/GlobalGuardiansPBEMUniverse'', Doctor XX was originally created to be an ongoing antagonist for the titular Global Guardians team. But then, after the GameMaster for the [[SuperheroSchool Hyperion Academy]] campaign got ahold of her, she tended to never appear in any other campaign so as to "not ruin her amazing portrayal in that campaign".
** In a reverse of the previous example, [[OmnicidalManiac The Blood Red King]] was originally intended to be a semi-demonic villain for the Knights of Malta (a team of superhero priests, monks, and nuns sponsored by the Roman Catholic Church). He ended up fighting the Global Guardians more than any other hero team in the setting.
* {{Lampshade|Hanging}}d on ''WebVideo/AtopTheFourthWall:''
-->'''Cloak #1:''' They think ''that's'' confusing? Why am I suddenly one of your bad guys when you weren't even in the group I was harassing in ''WebVideo/SuburbanKnights?''
* After WebVideo/TheNostalgiaCritic's battle with Creator/MaraWilson, she shows up in WebVideo/TheNostalgiaChick's review of ''Film/{{Matilda}}.'' At first Mara wants to kill her to get to the Critic, but since [[spoiler:he died in ''WebVideo/ToBoldlyFlee'']] the two try to come up with another reason to hate each other, to no avail. Later she appears in other Team [=NChick=] videos, with only a HandWave why she's not trying to kill anyone. [[RealLifeWritesThePlot She and Lindsay both live in New York]], so the transfer just makes things easier.

[[folder:Western Animation]]
* Most of the villains on ''WesternAnimation/BatmanTheBraveAndTheBold'' qualify, ComicBook/GentlemanGhost in particular. He was a minor enemy of Comicbook/{{Hawkman}}, but has had three episodes in a Batman-centric show devoted to him before Hawkman was even ''mentioned''. One episode actually had Batman replacing Hawkman in the Ghost's origin story, which more or less explains the difference. The series tried to do this on purpose. Outside of his own (rarely used) rogues' gallery, it's actually fairly rare for Batman to fight an enemy that regularly opposed the team up partner for that episode. (Featured team-up during Gentleman Ghost's origin story? ComicBook/{{Etrigan}}!)
* ''WesternAnimation/JusticeLeague''
** As mentioned in the comics section, Solomon Grundy does not fight against Franchise/GreenLantern ''or'' Franchise/{{Batman}}, but instead against Franchise/{{Superman}} and Hawkgirl.
** ''Unlimited'' portrayed Devil Ray (the CaptainErsatz of Black Manta) as a foe of Franchise/WonderWoman instead of ComicBook/{{Aquaman}}. This was due to rights issues with the failed ''Mercy Reef'' pilot that kept Aquaman himself from appearing in the last season of JLU.
** Gentleman Ghost and Shadow Thief spend most of their time fighting Franchise/GreenLantern instead of Hawkman, although it is due to their LoveTriangle involving Hawkgirl.
** Instead of being a foe of the Comicbook/{{Justice Society|OfAmerica}}, Roulette appears as a foe of the League.
* ''WesternAnimation/BatmanTheAnimatedSeries'' used Clock King and Count Vertigo, who were originally Comicbook/GreenArrow villains in the comics. Vertigo returned in ''WesternAnimation/TheBatman'' but this was in the last season when the show started focusing on assembling the Franchise/{{Justice League|OfAmerica}} and the episode he was in Batman shared with Comicbook/GreenArrow as a supporting role.
* Inverted in an episode of ''WesternAnimation/SupermanTheAnimatedSeries'' where Superman briefly takes over vigilante duty in Gotham, posing as Batman. He falls into a trap set by Bane, Mad Hatter and the Riddler, but escapes the trap with brute force, beating Bane into submission with ease, before using his super speed to apprehend the others, [[OutsideGenreFoe to their absolute shock.]]
* ''WesternAnimation/GreenLanternTheAnimatedSeries'' uses Byth Rok, who is traditionally a foe of Comicbook/{{Hawkman}}.
* ''WesternAnimation/BewareTheBatman'' uses Tobias Whale, who is traditionally an enemy of Comicbook/BlackLightning, and Simon Stagg, who is the archenemy of ComicBook/{{Metamorpho}} (who, unlike Black Lightning, did appear).
* Big Bad WesternAnimation/{{Pete}} originally appeared in Creator/WaltDisney's ''WesternAnimation/AliceComedies'' before becoming an enemy of WesternAnimation/OswaldTheLuckyRabbit and eventually Mickey Mouse. In the later years of Disney shorts, Pete mainly menaced WesternAnimation/{{Donald|Duck}}, though more as a [[JerkAss bullying jerkass]] than a straight up villain. To modern audiences he's probably best known for his role as Goofy's PoisonousFriend on ''WesternAnimation/GoofTroop'', or his role in the ''Franchise/KingdomHearts'' series.
* They aren't really villains, but WesternAnimation/ChipAndDale originally started out as recurring antagonists for WesternAnimation/{{Pluto|ThePup}}. Though they still pester Pluto at times, they're far better known nowadays for always bothering WesternAnimation/DonaldDuck, or else being key components of [[WesternAnimation/ChipNDaleRescueRangers the Rescue Rangers team]].
* ''WesternAnimation/TheAvengersEarthsMightiestHeroes'' essentially made the ComicBook/BlackPanther villain Klaw into an Comicbook/AntMan foe, as Ant-Man is the one who mangles his hand and later comes up with the strategy to defeat him. This left Black Panther without an ArchEnemy or someone to yell YouKilledMyFather at, so the writers made Man-Ape into his father's murderer instead.
* The 90's ''WesternAnimation/IronMan'' animated series had an episode with the Beetle, who as mentioned above is primarily a Spider-Man villain. The fact that he uses a suit of PoweredArmor like Iron Man and Comicbook/WarMachine allowed him to be depicted as one of Tony's {{Evil Counterpart}}s.
* The Mad Thinker and Awesome Android pop up in ''WesternAnimation/IronManArmoredAdventures'' as enemies (and classmates) of Tony and his buddies. In the comics, they're traditionally enemies of the Comicbook/FantasticFour. And then there's ComicBook/DoctorDoom and ComicBook/{{Magneto}}, who both show up in Season 2.
* Taken to the extreme in ''WesternAnimation/UltimateSpiderMan'', as part of the show's apparent attempt to be as different as possible to the traditional Spider-Man formula. So far, the show has largely avoided classic Spider-Man antagonists, the only ones showing up after more than ''twenty'' episodes being ComicBook/{{Venom}} ([[spoiler:with Harry Osborn as the host instead of Eddie Brock]]), ComicBook/DoctorOctopus, ComicBook/NormanOsborn (who doesn't become the Green Goblin until the ''season finale'') and Sandman. The other episodes involve either crossover episodes with other heroes involving villains from the guest-star's rogue gallery (Living Laser for Comicbook/IronMan, Loki for [[Comicbook/TheMightyThor Thor]], Zzzax for [[Comicbook/IncredibleHulk Hulk]], Mesmero and Sabretooth for Franchise/{{Wolverine}}) or villains from other Rogues Galleries who are treated like they were Spider-Man's regular villains (Doctor Doom, the Frightful Four, Batroc the Leaper, ComicBook/{{Taskmaster}}, Whirlwind, [[ComicBook/XMen the Juggernaut]]...) As an added twist, some of Spider-Man's foes are now tied to other heroes, such as Kraven being the one who killed ComicBook/WhiteTiger's father, and the Scorpion being from the same mythical city as [[ComicBook/ImmortalIronFist Iron Fist]].
* ''WesternAnimation/HulkAndTheAgentsOfSMASH'' has put the Hulks up against Annihilus, Blastaar, and Ego, the Living Planet, all longtime ''Comicbook/FantasticFour'' headaches. Bonus points for ''ComicBook/XMen'' foe Sauron. However, TheManBehindTheMan villain of the series is the Leader, who ''is'' a Hulk villain.
* ''WesternAnimation/AvengersAssemble'' uses Impossible Man, another Comicbook/FantasticFour enemy, as well as Doctor Doom.
* Dick Dastardly and Muttley started out as the enemies of the other racers in ''WesternAnimation/WackyRaces'' but then they gained a new enemy in Yankee Doodle Pidgeon in their own show, ''WesternAnimation/DastardlyAndMuttleyInTheirFlyingMachines''. But then the two started antagonizing ''WesternAnimation/YogiBear'' and the others starting with ''WesternAnimation/YogisTreasureHunt'', then it continues in ''Fender Bender 500'', ''WesternAnimation/YoYogi'' and ''Ride/TheFuntasticWorldOfHannaBarbera''. However due to rights issues they were replaced with Dread Baron and Mumbly and they antagonized Yogi and the others in ''[[WesternAnimation/LaffALympics Laff-A-Lympics]]'' and ''Yogi Bear and the Magical Flight of the Spruce Goose'', but the latter made them sound and act more like Dick Dastardly and Muttley so it's obvious on who they're replacing.
* The [[{{Satan}} Red]] [[CampGay Guy]] from ''WesternAnimation/CowAndChicken'' would also frequently antagonize ''WesternAnimation/IAmWeasel'' as well.
* While he isn't referred to by his real name, the same voice actor, the mirror mask, blue uniform hidden under trenchcoat and yelling "COBRA!" at the end of the episode made rather obvious the man called Old Snake, one-episode antagonist from ''WesternAnimation/TheTransformers'', is [[WesternAnimation/GIJoeARealAmericanHero Cobra Commander]].
* ''WesternAnimation/DuckTales'' had an episode called "All Ducks on Deck", where the villain was the Phantom Blot, who first appeared as an enemy of Mickey Mouse in old Mickey Mouse comics.
* ''WesternAnimation/LooneyTunes'': After years of trying and failing to catch the Roadrunner, a suddenly-voiced Wile E. Coyote showed up to antagonize WesternAnimation/BugsBunny in five shorts. That said, the final one, "Hare-Breadth Hurry" plays with this, as Bugs is essentially acting out the Roadrunner's usual role.
* According to the ''WesternAnimation/ThePowerpuffGirls'' episode "Bought and Scold", Quackor the Fowl from ''WesternAnimation/DextersLaboratory'' is one of their enemies. On a similar note, Huntor from "Dial M for Monkey" appeared as a bounty hunter in an episode of ''WesternAnimation/SamuraiJack'' called "Episode VIII: Jack vs Mad Jack".
* WesternAnimation/WoodyWoodpecker's traditional archnemesis Wally Walrus was placed against WesternAnimation/ChillyWilly in two 1961 cartoons, "Clash and Carry" and "Tricky Trout", 8 years since Wally's last appearance. Wally Walrus also antagonized WesternAnimation/AndyPanda in the 1946 cartoon "Dog Tax Dodgers".
* ''WesternAnimation/YoungJustice'':
** The ''majority'' of villains are not associated to any specific hero. Almost all the heroes work for or with the Justice League [[EvilIsOneBigHappyFamily while most of the villains are part of]] [[LegionOfDoom The Light]]. By the show's present time period, the whole concept of a Rogues Gallery [[ExaggeratedTrope has pretty much vanished]].
** Comicbook/LexLuthor never interacts with Franchise/{{Superman}} (though he retains his connection to ComicBook/{{Superboy}}). In fact, overall he comes comes off more as an [[Comicbook/GreenArrow Arrow Family]] villain--his first appearance sees him engaged in a XanatosGambit against [[spoiler:clone!]][[TheArcher Roy]], and he's eventually revealed to be behind [[spoiler:the capture of the original Roy Harper and creation of clone!Roy as a ManchurianAgent]].
* In ''WesternAnimation/TheIncredibleHulk1982'', some episodes pit the Hulk against other heroes' enemies.
** Spider-Man foe Doctor Octopus is the villain in "Tomb of the Unknown Hulk".
** "Prisoner of the Monster" features Iron Man adversary Spy Master as the antagonist.
** "Bruce Banner Unmasked" has the Hulk fight the Puppet Master, whose usual adversaries the Fantastic Four get no acknowledgement aside from his step-daughter Alicia Masters having a bust of the Thing among her statues of Marvel characters.
** The forces of Hydra are fought in "Enter: She-Hulk", when the organization is ordinarily an enemy of S.H.I.E.L.D. or Captain America.
* ''WebAnimation/DCSuperHeroGirls'' has a lot of this, largely due to many villains being alignment-swapped in this universe and pulling out more obscure DC villains to act as enemies. For instance, the Double Dare Twins are little-known ComicBook/{{Nightwing}} villains, but are often used in a VillainOfTheWeek role against Katana while he hasn't shown up at all. Dark Opal ''kind'' of counts, as while he menaces the DCSHG team, mainly Supergirl, here, his backstory {{flashback}} shows that he got there by running away from ComicBook/{{Amethyst|PrincessOfGemworld}}.
* ''Anime/BatmanNinja'' has Gorilla Grodd as being one of Batman's foes, despite having originated as a villain to ComicBook/TheFlash. Similarly, ComicBook/{{Deathstroke}} also appears and while he tangles with Batman fairly often, he was originally the ArchEnemy of the ComicBook/TeenTitans.
* ''WesternAnimation/MarvelsSpiderMan'' has two examples:
** The Blizzard used for this series, Randall Macklin, is a one shot enemy of Iron Man, who does not appear in this episode, and his origin involves Harry and Peter's invention.
** Absorbing Man is normally a foe of the Hulk and Thor, the former having appeared in only the Halloween episode, and the latter hasn't appeared at all.
* The ''WesternAnimation/SpiderWoman'' episode "Realm of Darkness" had Spider-Woman fight Dormammu, who was traditionally an enemy of Dr. Strange.
* Doctor Doom was featured as a villain in ''WesternAnimation/SpiderMan1981'' and its related series ''WesternAnimation/SpiderManAndHisAmazingFriends'', neither of which acknowledged his usual enemies the Fantastic Four.
* ''WesternAnimation/TheMarvelSuperHeroes'' had an episode of the ''Sub-Mariner'' segment feature Doctor Doom as its villain. Doom's usual enemies the Fantastic Four couldn't appear because of rights issues (having already been used by Creator/HannaBarbera for ''WesternAnimation/TheFantasticFour1967''), so they were replaced by the original roster of the X-Men, albeit referred to as the Allies for Peace.