A common trait of monsters is the WeaksauceWeakness that allows humans to face them. After all, if monsters are so powerful and scary how come that they haven't already took over us? Thus, [[TheFairFolk fairies]] are [[ColdIron repelled by iron]], demons run away in fear before a drop of Holy water, vampires [[WeakenedByTheLight can't stand sunlight]], werewolves only roam when there's a full moon, and so on. Not only monsters have this problem, very often characters that are too powerful are bound to have a restriction that, if they're villains, gives the Hero a chance against them and, if they're heroes, prevents them from being [[BoringInvincibleHero too boring to watch.]]

It follows that a villain with a weakness that both the Heroes and audience is familiar with, will instantly become a bigger threat if said character gets it removed. [[OhCrap Feel sorry for its enemies]] if their main strategy is AttackItsWeakPoint.

The weakness doesn't necessarily have to be a KryptoniteFactor, it could be a well known [[FlawExploitation flaw that the heroes always exploit]], like a detective that can always be sure that the criminal will left clues behind or that serial killers always follow a pattern that he can deduce to find them.

A character can achieve this [[TrainingFromHell through focused (and generally painful) training]], get this status as a side effect of increasing their powers, thanks to magical or scientific experiments, by being Badass or just gifted. To remove a KryptoniteFactor, a recurrent method is exposing to small doses of it, in a similar fashion to characters with AcquiredPoisonImmunity.

Just to be clear, this trope doesn't cover cases when the author changes the character into not having a weak point it used to have, it only counts when it happens in-universe. It also has nothing to do with heroic Ancient Greek amputees.

Compare with FightOffTheKryptonite, when the character doesn't lose his weakness but tries to fight it through sheer will force, and KryptoniteProofSuit, where the character takes measures to avoid it. Similar to NoSell, but instead of ignoring other characters' powers, in this case what's ignored are the natural weaknesses.

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Examples:

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[[folder: Advertising ]]

* A commercial for Nutrigrain breakfast bars had a family of vampires. One of the vampires stated "[[VampireVords Ve vere not morning people]]" until they discovered Nutrigrain bars--and showed them sitting at the table in sunlight having them for breakfast.

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[[folder: Anime And Manga ]]

* The Angels from ''Anime/NeonGenesisEvangelion'' had a Core that, if destroyed, would meant the Angel's destruction as well. But [[spoiler: the eleventh Angel had a body made of nanoentities, meaning that it didn't have a core, at least not that the heroes could detect and destroy as usual, but it also had an AdaptiveAbility that allowed it to learn and become immune to anything that they used against it]].
* Saiyans from ''Anime/DragonBallZ'' suffer an agonizing pain when their tails are squeezed. Goku used this against Raditz and Piccolo tried to do the same against Nappa, just to learn that he and Vegeta were inmune to this, the only apparent reason for that is that they were just too badass. Goku had also trained himself to remove this weakness in the past, before his tail was permanently removed.
* From ''Manga/JojosBizarreAdventure'' we have some examples:
** First one, [[spoiler: Cars, the BigBad from Part 2,]] a vampire that became immune to both sunlight and the Ripple, the only two things that could kill them.
** Second one, a villain from Part 4, [[spoiler: the BigBad Kira]], was the first character with a stand that could [[spoiler: operate regardless of distance, while the normal rule is that if there's a stand, its user is nearby. However, his stand had another limitations: it couldn't be controlled at will and Kira couldn't know what was it doing or seeing.]] He wasn't the last one.
** And third, in both Part 4 and 5 [[spoiler: there was a character whose stand would activate after the user's death, and since the only surefire way to destroy a stand was killing the user]], they were impossible to destroy.
* In the world of ''Anime/OnePiece'', there's an universal rule that says that, if you eat more than one Devil Fruit, you die. [[spoiler: Blackbeard]] has seemingly broken the rule, though no one but him knows how he achieved it.
* Walpurgisnatch from ''Anime/PuellaMagiMadokaMagica'', the only witch that [[spoiler: could exist outside a barrier and therefore wreak havoc on the real world]].
* An episode of ''Anime/{{Pokemon}}'' featured a trainer that made her [[ColdIron Steel-type Skarmory]] fight exclusively against [[PlayingWithFire Fire Pokémon]] until [[ScissorsCutsRock it overcame its weakness against Fire]].
** Another episode featured another trainer who had his [[DishingOutDirt Ground-type Sandshrew]] repeatedly dive into a pool to help it overcome its weakness against [[MakingASplash water]].
** Another trainer came up with a way to let her [[BlowYouAway Flying Pokémon]] ground [[ShockAndAwe electricity]] without getting seriously hurt.
* ''Anime/YuugenKaisha'' presents a literal example with [[OurVampiresAreDifferent Bosco]], who did this by repeatedly exposing himself to highpowered UV lamps to gradually build immunity to sunlight, as part of his attempt to give up being a vampire, [[spoiler: because he'd [[LoveRedeems fallen in love with Makiko.]]]]

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[[folder: Comic Books ]]

* ''KingdomCome'': It is revealed early on that because of all the yellow solar rays {{Superman}} has absorbed at that point, he gained an eventual immunity to all forms of Kryptonite, making him effectively invincible to everything but magic.
* Subverted by ComicBook/TheRiddler in the Franchise/{{Batman}} story that established that he's obsessively compelled to leave clues, otherwise he can't successfully commit a crime. The Riddler starts using forms of self-therapy to overcome his compulsion, and eventually manages to steal some jewelry without leaving any riddles. Meanwhile, Batman and Robin keep stumbling across strange people and events, which they end up connecting together to figure out Riddler's next crime. It's revealed when they catch him that Riddler hadn't overcome his compulsion--he started sleepwalking and left clues subconciously. In another storyline (possibly the same one), Riddler subconsciously leaving clues actually led him to surrender to Batman, because he realized this meant he really was crazy.

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[[folder: Film ]]

* Becoming this is Deacon Frost's goal in ''Film/{{Blade}}''. Until he completes the dark ritual, he and his followers have to use a thick covering of sun lotion to survive in sunlight.
* It happens in ''Film/IRobot'' , where everyone is pretty sure that robots would never attack a human due to [[ThreeLawsCompliant their programming]].
* In the climax of ''Film/{{Underworld}}: Evolution'', Selene gains immunity to UV radiation (and thus sunlight) by [[spoiler:drinking Alexander Corvinus' blood and becoming a vampire-Immortal hybrid]]. As previously shown, even the most powerful vampires suffer lethal burns when exposed to sunlight.
* Dracula in ''Film/VanHelsing'' displays none of the weaknesses commonly associated with vampires; Anna mentions multiple weapons that have failed to destroy him in the past, he survives being staked through the heart onscreen, and uses a CrossMeltingAura to destroy the silver crucifix Van Helsing threatens him with. Carl eventually figures out that the only thing capable of killing him is [[spoiler:a werewolf]].

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[[folder: Literature ]]

* The [[PuppeteerParasite Yeerks]]' from ''Literature/{{Animorphs}}'' need to leave their hosts once every three days to absorb Kandrona rays with their real bodies, otherwise they die of starvation. In their planet, [[AlienSky the Kandrona rays are generated by their sun]], on Earth they have a secret base with an artificial generator.
** A renegade Yeerk that couldn't afford to go back to the base found a way to survive anyway, [[spoiler: [[ImAHumanitarian by killing and eating a fellow Yeerk]] every three days.]]
** In another book the Yeerks found a substitute for Kandrona that they could absorb without leaving the host's body, [[spoiler: unfortunately it was highly addictive, hindered their ability to control the host, and could potentially drive them mad, [[SubvertedTrope replacing their original weakness with something worse]].]]
* ArtemisFowl: Demons, as a species, are no longer able to use magic after they reach their adult stage, called warping (warlocks are extremely rare, but don't warp). So when the BigBad starts using magic despite being, in his own words, "such a magnificently warped creature"... [[spoiler: it turns out there's an unconscious warlock's spirit inhabiting his body.]]
* The TerryPratchett book ''Discworld/CarpeJugulum'' has a family of vampires whose [[DangerouslyGenreSavvy father]] has trained them all to be immune to sunlight and to not react to holy symbols or garlic, as one is just a collection of lines and curves and the other is merely a member of the Allium family. [[spoiler: This [[JustForPun bites back]] [[HoistByHisOwnPetard hard]] at the end of the book, though, when the family can't stop seeing holy symbols everywhere. After all, they're just straight lines and curves...]]
* In ''Literature/HarryPotterAndTheGobletOfFire'', Voldemort uses Harry's blood in a ritual to restore him to power, which also allows him to bypass the PowerOfLove protection bestowed on Harry by his mother's sacrifice.
* Literature/HerculePoirot once faced a killer that he couldn't gather evidence against[[spoiler: because he didn't murder anyone, he subtly manipulated people with seemingly innocent remarks to hit their emotional buttons and push them into murdering]]. Poirot realized it but still was unable to bring the villain to justice, since none of his actions could be seem as a crime[[spoiler: so he broke his moral code and killed the guy, lamenting how that, at the end, the villain even managed to make Poirot himself a murderer.]]
* Saruman from ''Literature/TheLordOfTheRings'' created a new breed of Orcs after his FaceHeelTurn, the Uruk Hai, that weren't [[WeakenedByTheLight weakened by sunlight]] unlike ordinary Orcs. They were also stronger and overall superior.
* ''{{Twilight}}'' vampires feel a strong, almost uncontrollable urge for blood, [[spoiler: the only exception being Bella after her Vampification in ''BreakingDawn''.]]
* The clasic example in literature is Lestadt in AnneRice's ''{{Vampire Chronicles}}'' series. Knowing the oldest and most powerful vampires can withstand full sunlight, he chooses to accelerate the process, despite only being two hundred years old, by facing down the sun at noon. In a desert. Although the experience nearly kills him, his body eventually regenerates into the appearance of a man with a deep, permanent, suntan.

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[[folder: Live Action TV ]]

* Given the amount of vampires in ''Series/BuffyTheVampireSlayer'' and ''Series/{{Angel}}'', there's bound to be examples of vampires immune to their traditional weaknesses
** One involved removing the vampire's heart surgically (which will kill him eventually, but renders him immune to vampire weaknesses until then).
** Another example was when the Fang Gang goes to Pylea, Angel discovers that the dimension's sun doesn't harm him, allowing him to operate during the daytime.
** Dracula went to Gypsies sometime in the 1800 and traded vampire secrets for protection from a few Vampire weaknesses. Such as now he cannot be killed by a stake through the heart.
** The first ''Buffy'' and ''Angel'' crossover episodes featured a ring that made a vampire unkillable and featured a fight between Spike and Buffy in broad daylight. [[StoryBreakerPower Needless to say]], it was destroyed soon after.
* For many seasons it was established on ''Series/{{Supernatural}}'' that the special knives they had could kill ''any'' demon. Excepting any Satanic Kings Of Hell. However, a lady demon in season 8 just laughs off the knife wounds. (It was speculated that it was because the demon was really old, but it was never really addressed.)
* ''Series/TrueBlood'': Sookie's blood, because of her fairy ancestry, has the power to give vampires this ability.

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[[folder: Video Games ]]

* One of the characters in ''VideoGame/NeverwinterNights'' is secretly a werewolf, masquerading as a merchant and selling silver artifacts and wolfsbane herb to werewolf hunters. Not only does this keep suspicion away from him, but he also claims that [[AcquiredPoisonImmunity exposing himself to his weaknesses in this way has allowed him to build up a tolerance to them.]]
* ''VideoGame/LegacyOfKain'':
** Moebius has a sceptre that is enchanted to weaken any vampires he uses it against. Raziel is completely unaffected by the sceptre due to him being [[CameBackWrong 'remade']], and while Kain is initially affected by the sceptre, he discovers that he's become immune to its effects when Moebius tries to use it against him towards the end of ''Defiance'' (as a side-effect of [[spoiler:Raziel ripping Kain's heart from his chest during a previous encounter]]).
** And in ''Soul Reaver'', the Rahabim Vampires have evolved into amphibians, overcoming their vampiric weakness to water in the process. By [[spoiler: killing their leader Rahab and absorbing his soul]], Raziel also overcomes this weakness.
* In ''VideoGame/TheElderScrollsVSkyrim's'' ''Dawnguard'' expansion pack, the vampire Lord Harkon intends to create a permanent eclipse to black out the sun, allowing his clan to hunt freely without being hindered by their weakness to sunlight.
* In ''VideoGame/{{Xenoblade}}'', the otherwise hard to damage [[MechanicalMonster Mechon]] are easily dispatched by [[LegendaryWeapon the Monado]]. This isn't the case for the later introduced faced Mechon, who NoSell the Monado like any other weapon, which in turn forces to take them down the hard way.

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[[folder: Web Comics ]]

* ''Webcomic/TheAdventuresOfDrMcNinja''. Evil ninja Frans Rayner initially has a pressure point--when struck there, he is completely paralyzed for a short while. However, Rayner also has enough mental control over his body that, any time his pressure point is discovered, he can change its location. So, no paralyzing strike ever works against Rayner twice. [[spoiler:Eventually, Rayner completely eliminates his weak point. He suffers a mortal injury, and survives by becoming a cyborg--in the process, he has the presence of mind to shift his pressure point into one of his fleshy bits that gets cut off.]]

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[[folder: Western Animation ]]

* The Blood Bending ability from ''WesternAnimation/AvatarTheLastAirbender'' allows Water Benders to [[PuppetMaster control living beings using the water inside them]], but it's only possible on a night with a Full Moon, when Water Bending is boosted. In the sequel, ''WesternAnimation/TheLegendOfKorra'' , a famous criminal surprised everyone performing Blood Bending without a Full Moon thanks to his unique genetics. [[spoiler: His sons had the same ability.]]
* Demona from ''WesternAnimation/{{Gargoyles}}'' gained the ability to turn into human during day, instead of turning into stone like her brothers. While she hates humans and therefore hates her daytime form, she became more dangerous by having daytime to do as she pleases while normal gargoyles sleep.
* In ''WesternAnimation/{{Megamind}}'', Megamind creates a new superhero using [[BoringInvincibleHero Metroman]]'s genes. This new [[GoneHorriblyWrong "hero"]], Titan, has the same powers as Metroman. That's why Megamind is shocked to learn that, unlike Metroman, he's immune to copper. [[spoiler: In this case, it hints at the fact that Metroman was never weak against copper to begin with; he merely faked it.]]
* Mumm-Ra, the BigBad of ''WesternAnimation/{{Thundercats}}'', could, for all his strength and dark magic, be repelled if he could be tricked into seeing his reflection. Later on in the show he lost this weakness and was a significantly more dangerous threat because of it.
* In ''WesternAnimation/YoungJustice'', [[spoiler: ComicBook/{{Superboy}} could be put into a trance by LexLuthor with the phrase "red sun", due to him being cloned by Lex. The first time this happened to him, he woke up several hours after attempting to attack Lex.]] The second time he tries to [[spoiler:attack Lex]], the same thing happens; [[spoiler:until the rest of the team shows up and it was revealed that keyphrase was removed from his mind by Miss Martian.]]