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[[quoteright:350:[[VideoGame/DragonAgeII http://static.tvtropes.org/pmwiki/pub/images/dragon_age_red_eyes2_9974.jpg]]]]
[-[[caption-width-right:350:[[OurLawyersAdvisedThisTrope Warning]]: Using TheDarkArts may cause [[WithGreatPowerComesGreatInsanity insanity]], [[EvilMakesYouUgly disfigurement]], DemonicPossession, and [[ArsonMurderAndJaywalking inflamed eyes]].]]-]

->''"It's the red beady eyes that's a [[LampshadeHanging dead giveaway]] for the evil fellas."''
-->-- '''WesternAnimation/SpongebobSquarepants''', ''[[NicktoonsUnite Nicktoons: Attack of the Toybots]]''
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An easy way to tell a villainous (or sinister) character apart from the protagonists, other than giving him/her a RedRightHand, is making their eyes red. If they don't start out evil, there's a chance they become so over time or perform full-blown FaceHeelTurn. It's not the same thing as the "red eye" phenomenon in photos, but if cameras could [[EvilDetectingDog detect evil]], or danger these would be the first people they'd catch.

Even those who aren't truly evil or dangerous are often thought to be so by characters InUniverse.

In the progressive algorithm of UhOhEyes we have:

SupernaturalGoldEyes < Red Eyes, Take Warning < HellishPupils < GlowingEyesOfDoom

Those with [[GlowingEyesOfDoom glowing red eyes]] are almost without exception thoroughly evil or, at least, [[RoaringRampageOfRevenge very]] [[UnstoppableRage dangerous]]. The "almost" section goes to those whose red eyes serve as a marker for their ElementalPowers, typically [[PlayingWithFire fire]].

A subtrope of TechnicolorEyes. May be part of EvilAlbino, or [=averted/subverted=] by the HeroicAlbino, although most humans with albinism in RealLife have pale gray or blue eyes.

Compare GlamourFailure. Contrast RedIsHeroic.

Not to be confused with the film ''Film/RedEye'' or the liquor. Sometimes a part of BurningWithAnger.

'''It should be noted that trope is NOT just for characters who have eyes of this colour, but when the colour actually indicates the character is evil or dangerous, or presumed to be because of their eye colour. Please do not add characters who just happen to have eyes of this colour without the proper reason behind it.'''

[[noreallife]]
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!!Examples

[[foldercontrol]]

[[folder:Anime & Manga]]
* [[spoiler:Claire Stanfield]] from ''LightNovel/{{Baccano}}'' has reddish-brown eyes, rather than straight-up red, but they sure as hell [[http://img.photobucket.com/albums/v102/Ensuing/Baccano9/Baccano_24.jpg look blood red]] when [[spoiler:he's revealed to be the [[UrbanLegend Rail Tracer]]]], and he's prone to [[http://img.photobucket.com/albums/v102/Ensuing/Baccano9/Baccano_37.jpg combining these]] with GlowingEyesOfDoom and {{Slasher Smile}}s. The LightNovels also bring in [[PsychopathicManchild Christopher Shouldered]], whose defining features are his permanently and severely bloodshot eyes that appear to be almost entirely red, save the iris.
* In season 1 ''{{Beyblade}}'', the antagonist Kai, who betrays his team and steal bitbeasts, has red eyes. Also in season 3, when he is just about to go nuts, we see his eyes glowing red.
* ''Anime/TheBigO''
** The giant construction robot that goes berserk has a single glowing red eye that moves back and forth in its head like a 1970's ''Series/{{Battlestar Galactica|Classic}}'' Cylon.
** "Hydra". The giant three-headed electrical monster has many red eyes in lines along its head and body.
* ''Manga/BlackButler'''s Sebastian Michaelis has red eyes that are sometimes paired with glowing HellishPupils. Despite being a loyal butler to his young master Ciel, he's basically just tenderizing his soul until he's ready to devour it. Sebastian is very much a demon. Literally.
** Subverted with the Undertaker. [[spoiler: His eyes are [[GreenEyes green]] / gold instead of red, but in this context much the same. That is, a ''very, very bad sign''.]]
* ''Manga/{{Bleach}}''. Hollows are extremely dangerous spirit creatures.
** Anime episodes 2 and 3. The Hollow form of Orihime's brother had red eyes.
** Anime episode 9. The hollow Grand Fisher had glowing red eyes.
** Anime episode 210. After Captain Kensei Muguruma underwent hollowfication, he had glowing red eyes under his mask.
** Anime episode 214. The hollow that attacks Don Kanonji and Kisuke Urahara and the giant hollow fortress have red eyes.
** Anime episode 220. Captain Komamura's bankai, a giant samurai warrior, has glowing red eyes.
** Anime episode 260. A "sword beast" (rogue zanpakuto spirit) has red eyes.
* ''Anime/CowboyBebop''
** The assassin Tongpu in the episode "Pierrot le Fou".
** Anyone under the effects of the "red eye" drug, as seen in the first episode.
* In ''WebComic/{{Crepuscule}}'', having red eyes automatically makes you a vampire (though not all vampires are violent). The main character Lark proves an exception to the rule.
* ''LightNovel/CrestOfTheStars'' and its sequels have Admiral Spoor, a particularly volatile BloodKnight, who's marked as dangerous by her blood-red eyes. (Her personal flagship is of the same color.)
* Punie's mother, Esmerelda, from ''DaiMahouTouge'' has red eyes. She's as evil as her daughter.
* Contractors in ''DarkerThanBlack'' are usually completely indistinguishable from normal people, but when they use their powers, their eyes [[GlowingEyesOfDoom glow]] red.
* Shiro in ''Anime/DeadmanWonderland'', though it's semi-justified because she's an albino. She's not evil, but she's [[KillerRabbit definitely dangerous]].
** Played straight with [[CreepyTwins Chan and En]], as well as [[spoiler:Wretched Egg]], who are also albinos.
* In ''Manga/DeathNote'':
** Misa gets these after she receives the [[DeadlyUpgrade Shinigami eyes]]. The red eyes also show up for other characters who make this "trade", like [[spoiler:Kyosuke Higuchi, Teru Mikami, and Soichiro Yagami]]. In these cases, the red eyes are a stylistic representation of the power for the audience, but it's implied that there's no visual change in-universe. The LiveActionAdaptation instead uses SupernaturalGoldEyes.
** Red eyes are also used metaphorically for Light when his Kira persona shines through (i.e. when he's acting particularly diabolical).
* An inversion in ''DGrayMan'': If Allen's [[CursedWithAwesome cursed left eye]] turns [[HellishPupils black with red concentric rings]], you should probably start running. However, it's not a matter of running from ''him'' - it's because he just spotted an Akuma and you really don't want to be around when there's bullets flying through the air that can make you dissolve.
* ''Anime/DigimonTamers'':
** Green-eyed trickster Impmon is upgraded into red-eyed killer Beelzemon. After he finally leaves TheDarkSide, his eyes become green as Beelzemon as well.
* ''Manga/DogsBulletsAndCarnage'' gives us Heine. He's not exactly evil, just extremely AxCrazy.
* ''Anime/DragonBallZ''
** Frieza and his family all have red eyes, with the older brother, Cooler, combining this with GlowingEyesOfDoom for his Ultimate Form.
** The Oozaru transformation of the Saiyans, wherein they also get red GlowingEyesOfDoom and go [[{{Berserker}} completely berserk]].
** Majin Buu has reddish-orange irises in his second and third forms (in this case, combined with BlackEyesOfCrazy).
** In ''VideoGame/DragonBallOnline''; Characters possessed by the Evil Time Breakers were portrayed with Glowing Red Eyes.
** Characters possessed by Baby in ''GT'' also have flashing red eyes.
* ''Manga/ElfenLied''.
** Lucy has red eyes, is cute, and extremely deadly. Thinks almost all HumansAreBastards.
** All the other Diclonii, too, at least in the anime. Well, definitely Mariko. Nana is more debatable -- she's certainly dangerous, being a Diclonius and all, but doesn't seem particularly fond of killing people unless she thinks it's right.
* [=TheEnd=] from ''EurekaSeven'' has red pupils - though its eyes are more disturbing because of the way they roll around in their sockets. But, of course, [[spoiler: its eyes turn green after it makes a HeelFaceTurn]].
* Zeref from ''Manga/FairyTail'' usually has black eyes, but once he's sufficiently pissed off his irises will turn red. Since he's just about the only character in ''Fairy Tail'' who can successfully kill people, intentionally of otherwise, this is a sign that you should run.
* The demonic nobleman in ''Manga/TheFantasticAdventuresOfUnico'' has reddish eyes in human form. The eyes of any creature that he corrupts or manipulates seem to turn red as well.
* Whilst far from evil, Kenshiro from ''Manga/FistOfTheNorthStar'' is a ''very'' dangerous man who will sometimes gain [[GlowingEyesOfDoom Glowing Red Eyes of Doom]] when his sense of moral outrage is particularly provoked, such as when he confronted Ambia. Usually, those whose actions cause him to manifest said eyes [[LudicrousGibs tend to die very messily afterwards]].
* ''Anime/{{FLCL}}'':
** Ninamori has glowing red eyes while possessed by an alien monster in episode 3 "Marquis de Carabas".
** The giant hand monster in episode 5 "Brittle Bullet" has red "eyes" in its head.
** Mamimi has glowing red eyes twice while feeding the robot electronic parts and vehicles in episode 6 "[=FLCLimax=]".
* ''Anime/FutariWaPrettyCure'' has [[BigBad Jaaku King]], [[spoiler:[[TheDragon Illkubo]] when he fuses with a Zakenna]], [[DarkChick Regine, Viblis]] and [[DragonAscendant Baldez]].
* ''FutariWaPrettyCureSplashStar'' has [[PlayingWithFire Moerumba]], [[DarkMagicalGirl Michiru Kiryuu]] and [[NotSoHarmlessVillain Gohyan]] [[spoiler:who eyes becomes a bit orange when he [[OneWingedAngel transforms]]; he's also the real BigBad]]. Michiru subverts this [[spoiler:after her HeelFaceTurn.]]
* ''Anime/YesPrettyCure5'' has the DragonInChief Kawarino when he is sometimes mad. Averted with [[TheLancer Rin/Cure Rouge]] and [[SixthRanger Milk/Kurumi/Milky Rose]].
* ''Anime/FreshPrettyCure'' plays this straight initially and subverts it later. [[DarkMagicalGirl Setsuna Higashi/Eas]], a member of the evil world Labyrinth, has dark crimson eyes in human form and bright red eyes when transformed. [[spoiler: Then she undergoes a HeelFaceTurn thanks to ThePowerOfFriendship and becomes the decidedly not antagonistic [[SixthRanger Cure Passion]].]]
** [[spoiler:[[CoDragons Northa and Klein]] in their monster forms. Also their [[FusionDance fusion]].]]
* ''Anime/HeartcatchPrettyCure'' has [[TheDragon Sabaaku]] (a little bit pink) and [[TheBrute Kumojacky]].
* ''Anime/SuitePrettyCure'' has [[BigBad Noise]] in his [[spoiler:grown-up form and humanoid form.]]
* ''Anime/SmilePrettyCure'' has [[BigBad Pierrot]]. Sometimes, [[TheDragon Joker's]] eye [[GlowingEyesOfDoom glow]] red when he's angry or acts creepily. Wolfrun's eyes grow red when he LetsGetDangerous. Averted with [[TheLancer Akane/Cure Sunny]]
* ''Anime/DokiDokiPrettyCure'' has [[BigBad King Jikochuu]] and his [[DaddysLittleVillain Reg]][[TheDragon ina]]. Actually, Regina's eyes are blue, but when she's NotHerself she becomes really evil. [[spoiler:After being [[BrainwashedAndCrazy brainwashed]] by her father, her eyes are permanently red.]] Averted with [[spoiler:[[TagalongKid Aguri]]/[[TheBigGirl Cure Ace]].]]
* ''Manga/FullmetalAlchemist'': Played straight with [[AntiVillain Scar]], then later subverted with other Ishvalans who are, for the most part, victims and refugees of the Ishvalan War. [[spoiler:Also subverted when Scar becomes a good guy later on.]]
** Inverted when Al [[spoiler:uses a Philosopher's Stone to fight, and his eyes take on a noticeably darker (and incredibly awesome) tone.]]
* Natsume from ''GakuenAlice'' has red eyes in the manga, almost as a warning to the fact that he's a flame-caster (and will most likely try to burn you when he's angry at you). Though, in the anime, his eyes are brown.
* In the first ''VideoGame/GalaxyAngel'', Noah [[TheRealRemingtonSteele (or so we think)]] gets these once she performs the VillainOverride.
* Motoko Kusanagi of ''GhostInTheShell'' not only has bright red eyes, but chose the color herself. She's a very scary lady, to the point of remarking casually she's familiar with how to perform dental torture. [[spoiler: Later on, it's revealed that she chose the red eyes when she was cyberized at a very early age, and chose them along with her purple hair for no real reason other than the fact that kids like bright colors, then stuck with them because the hair and eye colors had become a part of her identity. But the "dangerous red eyes" trope still very much applies to her present day self.]]
* Shinn Asuka, the (initial) protagonist of ''GundamSEEDDestiny'', has red eyes. He's not evil, per se, but has definite anger issues.
* A mecha example in this one, ''{{Gundam 00}}'' features this in the Gundams. The primary celestial being units feature green particles, eyes, and clear pieces. The units that are not using the true GN drives feature the same pieces in red. Guess which ones are evil?
** However, this gets subverted later on in [[Gundam00AWakeningOfTheTrailblazer the movie]], which features the Gundam Raphael, which also has red eyes and particles, but is [[TheCavalry most definitely a good guy]]! And the same can be said of the Sol Braves team, and in fact [[spoiler: all of humanity]].
* The ''Franchise/{{Gundam}}'' franchise is full with these, actually; a number of Zeonic mobile suits are shown as red-eyed CyberCyclops, and due to the franchise's love for [[ShoutOut referencing itself]], a large number of suits in non-Universal Century timelines which are inspired by Zeonic ones (mostly the Zaku) have red optics. As a result, more than a few villainous suits have the glowing red 'eye' to warn viewers that they're not good guys. A few Gundam-like units have more human eye arrangements but are also red; this is most noticeable on the Delta Plus from ''Anime/MobileSuitGundamUnicorn'', which is otherwise mostly shades of blue. This suggests Riddhe's place in the story and his intents, or the type of danger he might pose [[spoiler:and that later he'll actually act on his crazed jealousy, enough to try and hunt down Banagher and the Unicorn]].
* ''HajimeNoIppo'': whenever Bryan Hawk lapses into the deepest pits of his AxCrazy, his eyes, excluding the pupils, become completely, bloody red. They even border on ''glowing''. It definitely helps making his batshit insane personality much more terrifying. In the manga (probably due to a lack of colors, duh), the eyes are [[BlackEyesOfEvil black]].
* ''Anime/{{Hakuouki}}'': glowing red eyes are one of the easiest ways to identify the [[OurVampiresAreDifferent Rasetsu]]. Aside from them, there's also Kazama Chikage, who has naturally red eyes and is the most dangerous villain of the series.
* In ''Manga/HeavensLostProperty'', Ikaros' eyes turning red means she has entered battle mode.
* In the ''{{Hellsing}}'' OAV, when Seras Victoria's eyes shift from blue to red (often [[GlowingEyesOfDoom glowing]]), expect bodies to hit the floor in numerous pieces. The first [[Anime/{{Hellsing}} Hellsing anime]] had Victoria's eyes change from blue to red permanently when she first became a vampire.
** But the character who ''really'' takes the cake with this trope is Alucard himself. Especially when he makes his {{Nightmare Face}}s. Oh, and if two red eyes aren't scary enough, how about a thousand of them?
* Satoko and her older brother Satoshi, from ''VisualNovel/HigurashiNoNakuKoroNi'', have red eyes. They subvert this, most of the time, by being very friendly. [[spoiler:However, Satoshi did [[MurderIsTheBestSolution kill his aunt]] and Satoko [[SelfMadeOrphan killed her parents]] due to the HatePlague.]]
* Kurapika from ''HunterXHunter'' falls into the "dangerous" (though not evil) category...normally polite and reserved, but if his eyes turn red, you'd better hope he's not looking at you.
* ''Manga/InuYasha'':
** Subverted with Kirara who was first introduced as a snarling beast with glowing red eyes. Then it's revealed she's a friend of Myouga's and was just trying to protect the bodies of the villagers who had cared for her. She becomes a friend and ally after that.
** Naraku's eyes are naturally red. As the BigBad, this is not good from the outset. When they begin to glow, however, true nastiness is about to happen.
** Subverted with Kagura. Her eyes are a solid red without pupils. Although introduced as a villain, CharacterDevelopment makes her an AntiVillain who tries to help Inuyasha's group, supports Sesshoumaru, and who ends up having an HeroicSacrifice to save Kohaku's life.
** Inuyasha and Sesshoumaru both have gold eyes, but when their sclera turn solid red, ''very bad things'' are about to happen to someone.
* In the ''Anime/IronMan'' anime, Dio's eyes briefly turn red when [[spoiler: it goes berserk]].
* In an odd twist, Guu from ''[[JungleWaItsumoHaleNochiGuu Haré+Guu]]'' has red eyes in her "normal" form, but considering that she's that world's rough equivalent of [[Creator/HPLovecraft Cthulhu]], it makes sense.
* EvilPrince Xanxus from ''Manga/KatekyoHitmanReborn'' has vicious bright red eyes to go with his nasty temper. Seriously, you do ''not'' want to piss him off.
* ''Franchise/LyricalNanoha''
** Subverted in the original ''Anime/MagicalGirlLyricalNanoha''. The red-eyed Fate Testarossa is introduced as an adversary and an apparent villain, but it quickly becomes apparent that she's the enemy more by circumstance than choice, and she does a HeelFaceTurn near the end.
** ''Anime/MagicalGirlLyricalNanohaAs'' has another subversion with the will of the Book of Darkness, who possesses red eyes with HellishPupils. She's introduced as the embodiment of an indestructible ArtifactOfDoom that destroys worlds, but is eventually revealed to be a tragic individual bound [[RidiculouslyHumanRobots to her corrupted programming]]. She also does a HeelFaceTurn near the end.
** ''AudioPlay/StrikersSoundStageX'' eventually reveals that the person directly responsible for the [[NightOfTheLivingMooks Mariage]] Incident is a another red-eyed character, [[spoiler:[[DetectiveMole Runessa]] [[DragonAscendant Magnus]]]].
** In ''Manga/MagicalRecordLyricalNanohaForce'', this is played straight (so far?) with Arnage of Huckebein, although it's not very clear if hers are red-red or more pinkish. She combines this with being an EvilRedhead to get CurtainsMatchTheWindow.
* Played straight with [[WhiteHairBlackHeart Ardi]] from ''MagicalXMiracle'', but partially subverted with Yue, whose one red eye doesn't seem to mark him as any more evil or dangerous than any other high-caliber [[RenaissanceMan wizard/politician/scientist]] (although his SleazyPolitician enemies may beg to differ).
* Evangeline occasionally did this in ''[[MahouSenseiNegima Negima!?]]''. In the actual {{Manga}}, the [[KenAkamatsu author]] prefers [[BlackEyesOfEvil Black Eyes]] for scary characters; black and white isn't quite up to portraying eye colour.
* ''Anime/MaiHime'': [[ManipulativeBastard trickster villain]] Nagi, who's an EnigmaticMinion and [[spoiler:one of [[TheDragon the Big Bad's sidekicks]]]] in ''{{Mai-HiME}}'', and the BigBad himself in ''{{Mai-Otome}}''.
* ''MiraiNikki'': Yuno sports red eyes, and she's a {{Yandere}}.
* Double subverted in ''MurderPrincess''. Alita and the rest of her family have red eyes, which no one comments on and are presumably normal. When Falis and Alita switch bodies, however, red eyes are the only warning you'll get.
* ''Manga/{{Naruto}}'':
** The Uchiha clan might as well be built around this trope. Every Uchiha's eyes turn red when using the Sharingan, and Itachi [[spoiler:and Obito]] pretty much ''always'' have them on.
** Used to some degree whenever Naruto used [[SuperpoweredEvilSide Kurama's chakra]] and his eyes turn red (with the added bonus of HellishPupils), though he is still aware of whose side he's on. When he reaches four tails [[spoiler: and above]], his eyes turn into [[GlowingEyesOfDoom glowing holes]], and ''that's'' when ''everyone'' knows [[OhCrap they're screwed]].
*** His eyes turn Orange Red and later pure red with his human pupil [[spoiler: when he uses Nine-tailed Chakra Mode and Biju Mode.]]
** Filler character Ranmaru has red eyes when he's using his unnamed eye jutsu. He's technically not evil, just willing to assist Raiga even if it involves helping him kill people, until he [[HeelFaceTurn sees the error of his ways]].
* In ''Manga/NausicaaOfTheValleyOfTheWind'', the gargantuan, pillbug-like Ohmus' rows and rows and rows of blue eyes shine bright red when they're [[UnstoppableRage enraged]]. Everything in their path is devastated afterwards, and the spores that collect on their bodies expand the Sea of Corruption a little bit more with each stampede.
* ''Anime/NeonGenesisEvangelion'':
** Angels tend to have red eyes (when they have them at all).
** Rei Ayanami and Kaworu Nagisa. [[spoiler:Rei and Kaworu are part Angels themselves]].
** In episode 18, EVA-01's eyes glow red [[NoHoldsBarredBeatdown when the Dummy Plug is activated]].
* In ''PandoraHearts'':
** Break also has reddish eye(s) and [[spoiler: it turns out that, back when he was the illegal contractor Kevin Regnard, he was also known as the Red Eyed Ghost]].
** [[spoiler:Oz]] gets these when using B-Rabbit's power.
** This trope is combined with ApocalypseMaiden for the in-universe concept of the Children of Misfortune. It is believed that children born with red eyes are inherently dangerous, causing tragedy simply by existing. [[spoiler: Glen Baskerville was responsible for making them DeaderThanDead, since their red eyes are a sign of their ability to influence the core of the Abyss]].[[spoiler:The recent informations reveals that everything about the Childern of misfortune were lies and that it's the Jurors that they were a threat to not the world because they were created by the core and because of this they were able to bypass their control and harm them which is why they wanted them to be destroyed.Oswald knew of this and used Vincent to scare them.]]
* ''Anime/PrincessTutu'':
** [[{{Ojou}} Rue]] / [[DarkMagicalGirl Princess Kraehe]]though she's more of a TykeBomb [[TragicHero tragic heroine]] than a straight villain.
** Also, [[spoiler:Mytho]], when he's possessed by Raven's blood in the second season...although they're almost more of a pink than a red. Considering the [[BigBad Monster Raven]] and his servants also have red eyes, it's probably a sign of Raven's blood.
* Subverted with PsychicDetectiveYakumo. The hero has one red eye, which means he can see the dead. However, it's normally hidden with a contact lens. However, the main villain [[spoiler: and Yakumo's blood father]] has two red eyes.
* [[WeaselMascot Kyubey]] of ''Anime/PuellaMagiMadokaMagica''. The end of episode 8 combines this with GlowingEyesOfDoom.
* ''Anime/RebuildOfEvangelion'': Has Rei and Kaworu retaining the red eyes. Then in 2.0 [[spoiler:Shinji gets them... by sheer force of will no less it seems.]]
* [[OurVampiresAreDifferent Inner Moka]] from ''RosarioToVampire'' is an ActionGirl who can CurbStompBattle just about any monster she meets. Sharp contrast to [[SplitPersonality Outer Moka]], who has green eyes and is basically harmless.
** If Tsukune EVER gains these, ''run''. No if and/or buts about it. It either means he's angry or [[SuperPoweredEvilSide wo]][[OurGhoulsAreCreepier rse]]...
* ''Manga/RurouniKenshin'': Makoto Shishio has narrow red eyes. His intro episode is appropriately titled "Devil of Vengeance". Earlier on, though, protagonist Kenshin Himura himself was exhibiting the trope as [[SuperpoweredEvilSide Hitokiri Battousai]] until his battle with Saitou Hajime gave him gold eyes, probably to match the prescribed manga coloring.
* ''Anime/SailorMoon'': Played straight by Black Lady and Galaxia before Sailor Moon 'befriended' her. Beryl's eyes were also red.
** The Seven Shadows in the series have them to the extremes. The ENTIRE eye is red. Sclera, iris, AND pupil.
** Fiore gets these when [[spoiler: merges with the Kisenian flower. After his defeat, he gets these when he tries to pull an IfICantHaveYou situation on the Senshi by crashing the asteroid they're all on into the Earth. LoveMakesYouEvil indeed]].
* In Act 1 of ''Anime/SailorMoonCrystal,'' MonsterOfTheDay Morga has light red sclera, and her BrainwashedAndCrazy human minions have red {{glowing|EyesOfDoom}} MindControlEyes until knocked unconscious by Sailor Moon.
* ''SaintSeiya''. Gemini Saga's eyes turn from a pleasant blue/green to bright red and glowing whenever his evil side takes over. When this happens, it's a good idea to run away very, very fast...unless you have a [[DeathSeeker death wish]], are TheHero, or [[TooDumbToLive both.]] His hair changes colour too.
* Inverted, discussed, and ultimately deconstructed for Gojyo in ''{{Manga/Saiyuki}}'': his red eyes are considered a bad omen because they mark him as a half-breed when paired with his [[CurtainsMatchTheWindow identically-red hair]], but this really only turns out to be unlucky for Gojyo himself, as he keeps getting treated as an outcast because of them.
* Demon Eyes Kyo from ''SamuraiDeeperKyo'' is the living incarnation of this trope. Even more impressively, he manages to do this and GlowingEyesOfDoom simultaneously. In an interesting subversion, the nature of Kyo's eyes and his connection to the enigmatic Mibu clan become central points to the plot.
* Ruby-Eye Shabranigdo, the supreme demon lord and SealedEvilInACan from the first season of ''{{Slayers}}''. Lina herself has them too, but while she's not a vilain, her record with property destruction certainly makes her dangerous.
* ''Manga/ShinryakuIkaMusume''. Ika Musume does this in the anime when she gets angry and unleashes her full power. Watch a brief example [[http://www.youtube.com/watch?v=4G3Gx0lBA6c#t=5m59s here]].
* Ralph Werec from ''SoukouNoStrain'' takes a different approach: he may not have red pupils, but the whites of his eyes turn pink when he [[FreakOut goes crazier than he usually is.]] The result is very creepy.
* In ''Anime/TekkamanBlade'', all of the enemy tekkamen had red eyes and red crystals. [[spoiler: When Blade exceeds his time limit and goes crazy, his eyes turn red as well.]]
** Present in the sequel too. Dead End had red eyes before his HeelFaceTurn.
* Silky from ''TenshiNiNarumon'' has red eyes. [[spoiler: In the first season, it is a subversion, but in the second one, it is played straight because she is a villain - of a raging psycho bitch variety. At the end, it is subverted yet again, because it turned out she really is a Woobie]].
* In ''Anime/UmiMonogatari'', this is averted with Kanon and the shrine maiden, but played straight with a corrupted Urin.
* Mutsumi from ''{{Utawarerumono}}'' has red eyes (as does Kamyu when [[spoiler:she goes into vampire mode]]).
* In ''VampireKnight'', the vampires' eyes turn red when they are suffering from blood lust. And Kaname's eyes are just red in general, and he's not exactly the most benign person...
* Dilandau in ''VisionOfEscaflowne'' has garnet-colored eyes and platinum hair, and he's totally crazy and bloodthirsty. Turns out, his true form [[spoiler:is a blond haired and blue eyed ''girl'']], so the hair and eyes are a side effect of the experiments performed on him.
* Sastre, a one-episode (but still formidable) ''WitchHunterRobin'' villain, has red eyes.
* ''TheWizardOfOz'': Wicked Witch of the West's eyes glow red every time she uses her magic in the 1986 series.
* Cheza in Anime/WolfsRain.
* [[http://static.tvtropes.org/pmwiki/pub/images/054.jpg Fuuma's]] eyes in the ''{{X1999}}'' anime series are dark red, in contrast to his manga counterpart, whose eyes can best be described as gold-hazel (giving him something of a cat-like appearance). The change in eye color probably has to do with the taken-for-granted aspect of his true nature in the anime series, while the manga builds up much more subtly towards the WhamEpisode and his FaceHeelTurn.
* Hatsumi[[spoiler:/Eve]] from ''YamiToBoushiToHonNoTabibito'' is a subversion. She has red eyes but is one of the more innocent and benevolent characters in the series.
* In the Toei-produced "Season Zero" of ''[[Anime/YuGiOhFirstAnimeSeries Yu-Gi-Oh!]]'', Yami's eyes were red. And bad guys really ''should'' take warning, because not only was Yami completely psychotic originally, but anyone who messed with his friends either ended up dead or even crazier than he was.
* The Red-Eyes Black Dragon in ''Anime/YuGiOhGX'', is the signature card of someone's SuperpoweredEvilSide.
* Kurogane from ''Manga/TsubasaReservoirChronicle'' has red eyes and appears to be a rather dark at the beginning, given his apparent bloodlust and over-enthusiasm for killing people who go after his [[{{Protectorate}} Princess]]. Subverted though when it's established that he is indeed a pretty good guy and probably the only one who is [[OnlySaneMan completely there]] amongst the main characters.
* Briefly in episode 22 of ''Manga/AttackOnTitan'' Levi's eyes become red when attacking [[spoiler:the Female Titan]] for [[spoiler:killing his squad]]. Take warning, indeed.
* ''Manga/OnePiece'': Sort of, but if you ever see Luffy looking at you with his pupils not fully black, RUN.
* ''Anime/YuYuHakusho'': Some of the demons. Though many demons appear to have this trait ''not'' as a default eye color, but whenever it appears that they've tapped into their demonic nature overlapping with GlowingEyesOfDoom. Reminding you of their nature.
* In ''Anime/MekakucityActors'' (the anime adaption of the ''Franchise/KagerouProject''), all of the members of the Mekakushi Dan's eyes glow red when they use their [[MagicalEye powers]].
[[/folder]]

[[folder:Comic Books]]
* The original version of the MarvelUniverse supervillain The Basilisk.
* In ''The Brute'' #1 (Atlas Comics, February 1975), the [[http://goodcomics.comicbookresources.com/wp-content/uploads/2010/02/brute1.jpg eponymous creature's eyes glow red when a man knocks his friend, Dr. Turner, unconscious]]. He then [[http://goodcomics.comicbookresources.com/wp-content/uploads/2010/02/brute2.jpg kills the man by throwing him against a wall]].
* CaptainAmerica had these at the end of a What If issue. He was pretty pissed at that moment.
* In the DCUniverse the Demon {{Etrigan}} is extremely evil and cruel and has fiery red eyes.
* It depends on the artist, but SelfDemonstrating/TheJoker sometimes has red eyes.
* DonaldDuck and his uncle Scrooge [=McDuck=] get the red eyes and very scary expressions whenever they get '''really''' [[UnstoppableRage angry]].
* The [[EvilTwin Copy Robot]] in ''ComicBook/MegaMan'' issue 4.
** Mega Man himself as he was infected by Wily's malware.
* One of the first signs that something is up in ''ComicBooks/{{Flashpoint}}'' and [[WesternAnimation/JusticeLeagueTheFlashpointParadox its cartoon adaptation]] is that Batman's got red eyes/visor lenses instead of white... because [[spoiler:Bruce died that night in Crime Alley, the Batman in ''Flashpoint'' is his father Thomas]].
* Lampshaded in the second story-arc of ''ComicBook/MyLittlePonyFriendshipIsMagicIDW''; when Applejack spots a group of cute Nightmare creatures, the nearest of which have sparkly red eyes, she asks Fluttershy for her opinion on their significance:
-->'''Fluttershy:''' Possible inherent evil?
* Jesse Custer of {{Preacher}} gets red eyes when using [[CompellingVoice The Word]].
* The {{New52}} version of ''Comicbook/{{Superboy}}'', when using his telekinetic abilities.
* {{Superman}}, big time. Granted, his eyes nearly always glow red just before he uses his heat vision in any context, but Superman with BIG glowy red eyes and an angry expression fits this trope and means that someone's about to get seriously hurt. Notable examples include ''ComicBook/ForTheManWhoHasEverything'' (to Mongul: "Burn"), "JLA/Avengers" (in his fight against Thor), and "Kingdom Come", where he had to be talked down from murdering the entire UN Assembly in the final chapter. But perhaps his best display is when Darkseid ''apparently'' killed Supergirl in the SupermanBatman arc, and Superman, after shedding some tears for his cousin, donned his red eyes of doom and gave Darkseid the beatdown of a lifetime.
** [[http://superdickery.com/images/stories/dick/1931669superdickery.jpg An example]] from Superdickery.com.
** Subverted in ''LexLuthorManOfSteel''. Superman is ''always'' presented with red eyes, but it's due to Luthor's UnreliableNarrator perspective. And the fact that whenever Superman and Lex Luthor are face-to-face with each other, the reason ''behind'' Superman's glowing, angry red eyes is usually because Luthor's just done something utterly monstrous and gotten away with it.
* According to the Marvel handbook, this ''should'' be the case for ComicBook/WerewolfByNight: his eyes are yellow when he is transformed and fully in control of himself; when he transforms involuntarily and becomes a dangerous, wild animal, they are red. Unfortunately [[DependingOnTheArtist the colorists don't quite adhere to this]] and the two often get switched around.
* If {{X-23}}'s eyes turn red, run. Run away ''very'' fast. It means she's under the effects of the trigger scent and you're about to die a horrible, meat confetti death.
[[/folder]]

[[folder:Fan Works]]
* In ''FanFic/APikachuInLove'', this is the first thing Pikachu and Pichi see [[spoiler: after accidentally crashing into an Ursaring's den...]]
* ''Fanfic/AceCombatTheEquestrianWar'' has Red Cyclone, whose eyes sometimes give out a spark or two when he devises a plan.
* ''Fanfic/TheBridge'' gives us Monster X. When we get our first image of him, the only thing visible under the cloak he's wearing in his glowing red eyes [[spoiler: partially subverted as he's a NobleDemon ]]
* The ''WesternAnimation/KungFuPanda'' fic ''A Different Lesson'' uses this to signify a character falling under MoreThanMindControl...assuming the reader hasn't figured it out by the time the eyes show up.
* Parodied in ''Fanfic/CalvinAndHobbesTheSeries'', where the MirrorUniverse equivalents of Calvin and Hobbes only have red eyes because they got soap in them while showering.
--> '''[[SdrawkcabName Sebboh]]''': It's still burning.
** This is played straight later on when [[SnarkyNonhumanSidekick Jack]]'s MoralityDial is flipped.
* In the webcomic adaptation of ''Fanfic/ChristianHumberReloaded'', the sociopathic mass-murdering protagonist has red eyes.
* ''FanFic/DungeonKeeperAmi'' features this prominantly. Keepers all have red, glowing eyes; these glow brighter when feeling strong emotions, such as anger. This actually becomes a plot point once Ami makes contact with her own world, and is the basis of Tiger's rather [[DudeNotFunny annoying prank]].
* Averted and played straight in ''MyImmortal''. Vampires Ebony and Draco either have red eyes or wear red contacts, and are ([[DesignatedHero supposedly]]) good guys. Played straight in that Vloxemort, the BigBad of the story, is frequently described as having red eyes.
* In ''FanFic/PuellaMagiYuukoMagica'', Madoka's eyes shift to a shade of red when she's about [[LetsGetDangerous to get really dangerous]].
* In ''Fanfic/QueenOfAllOni'', [[WesternAnimation/JackieChanAdventures Jade]] gets red eyes when she returns to her Queen of the Shadowkhan persona.
* RescuingDara [[AvertedTrope averts]] this trope, with the hero Chivai and both the heroic and villainous Lucarios all having red eyes.
* In the ''Warcraft'' fanfic ''[[http://www.fanfiction.net/s/4599507/1/Tales_of_a_Warrior Tales of a Warrior]]'', the lead, Keleria, who is already a {{berserker}}, develops these whenever she slips into blood rages.
* The DarkFic ''TheTerribleSecretOfAnimalCrossing'' has a few pictures of [[spoiler:Tom Nook]] with these eyes. Really quite freaky.
* [[http://salacommander.deviantart.com/art/TEAM-PSYCHOTIX-Ch-1-Pt-1-97095949 "A shadowy figure slowly opened his red, glowing eyes (they’ve got to be glowing, otherwise we wouldn’t be able to tell if he opened them or not, and they’ve got to be red, because, c’mon, what other color would they glow)"]]
* In the {{Manga/Bleach}} fanfic ''[[https://www.fanfiction.net/s/8222340/1/Chasing-the-Moon Chasing the Moon]]'', [[spoiler:Kurosaki Yuzu]] is a MartialPacifist, and an absolute sweetheart. That doesn't stop her final bankai technique from giving her these. It's supposed to represent the way a lunar eclipse causes a [[BadMoonRising blood moon]]. [[BewareTheNiceOnes Run?]]
[[/folder]]

[[folder:Films -- Animated]]
* Franchise/DisneyAnimatedCanon:
** Mrs. Jumbo from ''Disney/{{Dumbo}}'' normally has blue eyes like her son, but they turn red during the scene where she goes crazy as a result of several children making fun of Dumbo, resulting in her being tied up by several circus workers and subsequently being dragged away to be locked up in solitary confinement as punishment for being a "mad elephant".
** Pongo and Perdita from ''Disney/OneHundredAndOneDalmatians'' when they are fighting [[ThoseTwoBadGuys Horace and Jasper]] in Hell Hall. Cruella De vil's NightmareFace also counts.
** In ''Disney/TheBlackCauldron'', the Horned King's eyes go angrily crimson after his army of undead warriors has been halted.
** ''Disney/{{Aladdin}}''. While Aladdin and the Genie are in the cave, Aladdin taunts the Genie about the limitations on his wish granting abilities to trick him into getting everyone out of the cave without using up a wish. When the Genie gets angry and starts giving a speech, his eyes turn red momentarily.
** In ''Disney/TreasurePlanet'', Silver's cybernetic eye is usually a yellowy-amber-orange-ish colour, but it changes to red when he gets angry/displeased.
* In ''WesternAnimation/CareBearsMovieIIANewGeneration'', [[BigBad Dark Heart]] has red eyes ([[EvilRedhead and hair]] [[ColorCodedForYourConvenience and clothes]]) in his human form. When his eyes change color, it clues everyone in that [[spoiler:his HeelFaceTurn turned him into [[BecomeARealBoy a normal kid]]]].
* [[http://toonguru.com/CDD/screens/scenes/12/pages/CDD012_063.htm Darla Dimple]] in ''WesternAnimation/CatsDontDance'' has eyes that flash red when she's feeling particularly insane.
* Fidget, [[http://images4.fanpop.com/image/polls/590000/590681_1291376651365_full.jpg when he breaks through the window]] in the beginning of ''Disney/TheGreatMouseDetective'', has Red Eyes. [[BigBad Ratigan]] also [[http://images1.wikia.nocookie.net/__cb20110621184252/villains/images/b/b6/Ca_va_saigner_%21%21.jpg qualifies]] during the climax of the film, after his VillainousBreakdown.
* ''WesternAnimation/HeavyMetal''.
** "Den". The evil queen's eyes flash red for a moment when one of her underlings criticizes her having sex with a prisoner.
** "Taarna". The giant rats that the Barbarian Leader has as his {{Right Hand Cat}}s have bright red eyes.
* Rudy the Baryonyx from ''WesternAnimation/IceAge 3'', although this is more EvilAlbino.
* When the titular [[WesternAnimation/TheIronGiant Iron Giant's]] eyes turn red, it's a good idea to remove yourself from the area.
* [[EvilAlbino Lord Shen]], the BigBad of ''WesternAnimation/KungFuPanda2'', has red eyes, due to him being an albino peacock.
* Nyra's eyes in ''WesternAnimation/LegendOfTheGuardiansTheOwlsOfGaHoole'' glow red when she's angry.
* The PNK sorority girls in ''WesternAnimation/MonstersUniversity''. They're usually bubbly valley girl types, but when they get down to scaring, ''yikes''.
* Spoofed in ''WesternAnimation/MonstersVsAliens''. After being imprisoned by the military merely for being a [[AttackOfTheFiftyFootWhatever 49 foot 11 inch monster woman]], Susan starts banging on the walls of her prison. The other monsters warn her not to do that, whereupon a huge door opens to reveal a dark interior with two [[GlowingEyesOfDoom glowing red eyes]] within...which merely turn out to be the lights on General Monger's JetPack.
** Played straight with the alien probe. When its eye turns red, there's little hope for you if you're in its way.
* The Fabrication Machine and all its robot minions in ''WesternAnimation/{{Nine}}''.
* ''WesternAnimation/ThePenguinsOfMadagascar: Operation Blowhole'' provides a [[LampshadeHanging lampshaded]] example when the Julian doll's eyes start glowing red.
--> '''Skipper:''' Glowing red eyes, [[GenreSavvy that's almost never good.]]
* In ''WesternAnimation/SupermanVsTheElite'' [[spoiler:once Superman decides to fake crossing the MoralEventHorizon, not only do his eyes glow red. The blood vessels in his left eye were damaged earlier in the fight, giving that eye a reddish tint, which only adds to how shit-scary he is at the time.]]
* In ''WesternAnimation/TheThiefAndTheCobbler'', all of the One-Eyes (an evil race that plans to destroy an idyllic Golden Land) have a single, big red eye.
* ''WesternAnimation/ToyStory2''. Emperor Zurg has glowing red eyes.
[[/folder]]

[[folder:Films -- Live-Action]]
* A rare yellow colored variation of this trope happens at the end of ''Film/AngelHeart'' [[spoiler: when LouisCypher is telling Harry Angel that he was the missing cannibal serial killer Johnny Favorite and that Johnny's (And therefore, Harry's) soul is his, for a brief couple seconds, his eyes turn yellow.]]
* Freddy Krueger had them in ''Film/ANightmareOnElmStreetPart2FreddysRevenge''. Subsequent films gave him normal looking ones, though.
* In ''Film/{{Apollo 18}}'', one of the symptoms of the parasite infection is a red ring around the host's irises.
* The demonic halfbreeds in ''Film/{{Constantine}}''.
* [[Film/{{Cthulhu}} "Do it, Russell! Make sacrifice! Look into the red eye of your god!"]]
* In ''Film/{{Dreamscape}}'', the SavageWolves chasing the heroes in the final dream sequence.
* ''Film/TheFog'' (1980). Blake, the leader of the zombie ghosts, has glowing red eyes.
* Vampires in ''Film/FrightNight'' (1985). Jerry Dandridge and Amy Peterson in their humanoid forms, Jerry Dandridge in bat form, and "Evil" Ed Thompson in wolf form all have red eyes. HammerHorror vampires often have red -- or rather, very bloodshot -- eyes.
* ''Film/{{Ghostbusters}}''.
** Gozer's dog demons Zuul and Vinz Clortho both have glowing red eyes.
** After Tully is possessed by one of the dog demons, his eyes flash red when he becomes angry. Dana Barrett's eyes also become red after she is possessed.
* Voldemort in the first Harry Potter film, staying true to the original story. Later films were much less accurate, giving him blue eyes for no real reason.
* Monster X in both forms in ''Film/GodzillaFinalWars''.
** In ''Film/GodzillaTokyoSOS'', the title character tries to charbroil Mothra's newly borne twin larvae with his atomic breath. Mothra [[HeroicSacrifice jumps in front of her children to save them]] and is promptly [[KillItWithFire set alight]] for her troubles. She explodes and, at that point, her children's eyes turn from a benevolent blue to a hellish red and they proceed to team-up with Mechagodzilla to beat the hell out of Godzilla.
** Space-Godzilla has glowing, red, eyes with [[HellishPupils cat-like slits]] as opposed to Godzilla's fiery, human-like ones.
** Others include [[KnightTemplar Battra]], [[BlobMonster Hedorah]], [[CyberCyclops Gigan]] and [[EldritchAbomination King Ghidorah]].
** The Mutos from ''Film/{{Godzilla 2014}}'' have red glowing slits for eyes, which lack any kind of pupils. They may be heat sensors or compound eyes.
* Mogwai in the ''Film/{{Gremlins}}'' series when they've eaten after midnight and become evil.
* It's not the eyes, but the robots in ''Film/IRobot'' turn on a red chest light when being controlled by the villain. [[JustifiedTrope Justified]]: it's explained that the red light indicates when a robot is downloading a firmware update from US Robotics. [[spoiler: VIKI uses this connection to upload her (twisted) logic and understanding of the Three Laws into the consumer-model NS-5's.]]
* In ''Film/IronMan2'' The Mk II eyes light up blue like all Iron Man suits--as War Machine, they are red.
* In ''Film/JudgeDredd'', the deadly ABC robot controlled by Rico has glowing red eyes.
* ''Film/TheLeagueOfExtraordinaryGentlemen''. Mina Harker gains red eyes when she lets her inner vampire out.
* As well as [[BigBad Sauron]] in ''Film/TheLordOfTheRings'', being a flaming red eyeball himself, the black horses of the Ringwraiths have glowing red eyes.
* ''Film/ManOfSteel''
** [[spoiler: Zod in the final battle, when he cuts loose with his full set of Superman-like powers -- including heat vision.]]
** Inverted, as when Lois first sees Clark in the cave, his eyes are glowing red as well. He soon [[spoiler:cauterizes her injury with his heat vision.]]
* ''Film/TheMatrix''. The Sentinel "search and destroy" robots (which threaten the humans in the real world throughout the trilogy) have multiple glowing red eyes.
* Although we never actually get to see their real eyes, the glowing red goggles of the Red Eyes gang in ''Film/MysteryMen'' seem to reflect this trope.
* This happens to Falcor in ''Film/TheNeverEndingStory 2'', when he refuses to carry the sorceress Xayide.
* ''Film/{{Oblivion 2013}}'' : You didn't expect the HAL 9000-eyed drones to be up to any good, did you?
* ''Film/OneHourPhoto'' has Robin Williams in a calm dream sequence, but when he opens his eyes, [[spoiler:they are blood red and some blood trickles out of one. He then puts his hands on his eyes, screaming out "AAAAHHHHHHH!" while blood flies all over the place from his eyes]].
* Film/{{Popeye}} and a very late Olive Oyl in TheMovie carrying the newly discovered [[DoorstopBaby Swee'Pea]] at the door of Olive's house after being late for a date with Bluto=big trouble. Bluto, seething with anger, sees Popeye, Olive, and the baby through red eyes, pummels Popeye into the ocean below, and, in the next scene, persuades the taxman to tax the prestigious Oyl family into bankruptcy as revenge.
* Subverted in ''Film/{{Spaceballs}}''. When the baby xenomorph bursts out of John Hurt's chest, it has red eyes, but it immediately goes into its "Michigan J. Frog" number and dances away.
* ''StarWars'': the "Sith eyes" seen on Darth Sidious, and later Darths Maul and Vader in the prequels (technically gold rimmed and flecked with red, but it still counts) Maul is shown to have them all the time, but he's not human and his eye color is never seen while he's doing anything but hunting the heroes and fighting. Vader is only seen with them when he's feeling particularly "eeevil." Sidious' eye color, on the other hand, switches between Sith gold and their original blue depending on whether he is being his evil self or masquerading as a benevolent politician. Ultimately, his eyes become gold-red permanently after his gruelling duel with Mace Windu.
** This trope is subverted with Darth Tyranus, who is never seen with Sith eyes.
** The eyes of Cad Bane from "[[StarWarsTheCloneWars Clone Wars]]", the Nemoidians and Grand Admiral Thrawn may fit this trope better on a superficial level (being pure red), but this is only because that's the natural eye color of their respective races - not Sith sorcery.
** In the theatrical version of A New Hope, Vader's eye lenses had a dull reddish tint to them due to the materials used. It probably wasn't intentional, due to the fact that later edits removed the reddishness in order to hide David Prowse's eyes.
* In ''Film/TeenWolf'' (1985), Scott's eyes flash red and his voice drops to an evil growl to intimidate the hard-ass old man into selling him a keg of beer.
* Most of the Terminators from, well, the ''Franchise/{{Terminator}}'' franchise have [[GlowingEyesOfDoom glowing red eyes]], which become even more obvious when only their endoskeletons are showing.
** It is probably not coincidental that [[Series/TheSarahConnorChronicles Cameron]] has blue eyes under the meat...although [[Film/Terminator3RiseOfTheMachines the third movie]] features another quite malevolent Terminator similarly equipped.
*** [[http://images2.wikia.nocookie.net/terminator/images/thumb/8/87/Cameron_redeye2.jpg/250px-Cameron_redeye2.jpg Actually, Cameron's endoskeleton has red eyes.]] The blue light we saw in some episodes was explained by Josh Friedman: "It's red because at the core, she's a Terminator. Plain and simple. The lens itself is red. There'd never be a reason to change the lens color. I made [the flash] blue in the pilot to indicate she was different but that wasn't to suggest the hardware was blue. No reason for it." Some theorized that the blue eyes were some sort of Resistance Security Encryption Key, considering its use in unlocking access to both the TDE station in the vault (for the Connors) and the TDE complex in the future (for Derek).
* The Hood, the villain of the live action ''Film/{{Thunderbirds}}'' film, has these when he uses his psychic powers. His heroic niece, Tintin, has SupernaturalGoldEyes in contrast, when she uses her powers.
* The Infected in ''Film/TwentyEightDaysLater'' have red eyes. They're also ''very'' aggressive.
* The HAL 9000 computer in ''Film/TwoThousandOneASpaceOdyssey'' uses cameras with glowing red lenses to watch the crew of the Discovery.
* In ''Film/WhoFramedRogerRabbit'', Eddie Valiant remembers that the toon who killed his brother had "burning red eyes". That toon is later revealed to be [[spoiler: Judge Doom]].
* ''Film/TheWizardOfOz'' (1939). In the Haunted Forest, Dorothy and her companions see two evil owls and two vultures. All of these birds have glowing red eyes.
* Bishop in ''Film/XMenDaysOfFuturePast''.
* ''Film/YoungSherlockHolmes''. When the gargoyle in the shop starts to animate, its eyes glow red.
* In the 1994 film ''Film/TheMask'', Dorian Tyrell is this when he puts on the mask that brings his hidden dark side to light.
[[/folder]]

[[folder:Literature]]
* ''TheAmityvilleHorror''. The youngest child, 5 year-old Missy, had repeated encounters with a pig-like demonic creature with red glowing eyes whom she called Jodie.
* Melisandre from ''ASongOfIceAndFire'' is an EvilRedhead [[CurtainsMatchTheWindow as well.]]
** The direwolves have red eyes. The ones the Stark children have are not evil, but dangerous indeed.
*** Only Ghost has red eyes, and that's because he's an albino. The other Stark direwolves have yellow, gold, or green eyes.
* One of the villains from Madeline L'engle's ''Literature/AWrinkleInTime'' is called simply...The Man With Red Eyes.
* OlderThanPrint: the monster Grendel from the Old English poem ''Literature/{{Beowulf}}'' is described as having glowing red eyes: "on fagne flor feond treddode,/eode yrremod; him of eagum stod/ligge gelicost leoht unfćger" ("Across the decorated floor the fiend trod, went enraged in mind; there stood in his eyes a foul light most like to flame").
* ''BoredOfTheRings'', a parody of ''TheLordOfTheRings'': the Black Riders have "perfectly normal red glowing fires" where their eyes should have been.
* Mayor Oculon of ''Literature/CityOfDevils'' has... well, ''is'' a giant red eye. With tentacles.
* In Creator/RobertEHoward's Franchise/ConanTheBarbarian stories "Literature/ShadowsInZamboula" and "Literature/QueenOfTheBlackCoast", villainous {{Evil Sorcerer}}s have red eyes.
* MichaelMoorcock's ''[[{{Corum}} The Queen of the Swords]]''. Prince Gaynor the Damned, an evil champion of Chaos, has dead red eyes that blaze in terror and agony.
* Subverted in the web-novel ''Literature/{{Domina}}''. A lot of the demons have red eyes, but since it's optional, they almost certainly chose them to [[InvokedTrope invoke]] this trope for intimidation.
* Literature/{{Dracula}} has red eyes. His houseguest, Jonathan, being [[StiffUpperLip Br]][[TheStoic it]][[TooDumbToLive ish]], does not comment on this.
* ''Dragontales'', a collection of ''TabletopGame/DungeonsAndDragons''-related stories.
** In "Out of the Eons'', a Gardner F. Fox "Niall of the Far Travels" short story, the evil deity Adonair has wide fire-red eyes.
** "Black Lotus Moon". The huge guardian monster in Garilon's tower has large, saucer-shaped eyes with red irises like clots of blood.
* The villainous Steerpike of Mervyn Peake's ''Literature/{{Gormenghast}}'' series has dark red eyes.
* Lord Voldemort from the ''Literature/HarryPotter'' books (although not in [[TheFilmOfTheBook The Films of the Books]], except the first, which actually gets it right).
** Red eyes seem to imply evil thoughts/feelings. Young Tom Riddle's eyes gleam red briefly at a moment when he is extremely greedy, and later, when he has started turning into Voldemort, his eyes become bloody-looking - they ultimately end up staying pure red after he splits his soul seven times. Also, when Ron is being psychologically tortured by Riddle!Harry-and-Hermione from the horcrux, his eyes flash red for just a second...before he ignores them and [[CrowningMomentOfAwesome shuts them up for good.]]
** Notice the formidable chiasmus at the end of ''[[Literature/HarryPotterAndTheGobletOfFire Goblet of Fire]]''. Voldemort has red eyes and uses a green DeathRay. Harry Potter has good green eyes, and uses the good red ray (remember the color-coding of laser beams in the original StarWars trilogy).
* Creator/HPLovecraft's CthulhuMythos story ''The Haunter of the Dark''. The titular monster has a red, three-lobed, burning eye.
* Mentioned a lot in ''Literature/TheHouseOfNight'' as the Red Fledglings and Vampires have red eyes when they've just fed from a human or when they're seriously pissed off. The Raven Mockers also have red eyes.
* In the ''Literature/LeagueOfMagi'' stories, Rose Cross has red eyes as a symptom of her albinism. She's not quite ''evil'', but she's definitely scary.
* In R. A. Salvatore's ''TheLegendOfDrizzt'', the [[AlwaysChaoticEvil drow]] have deep red eyes. This trope is carried even further in that Drizzt, one of only two good drow seen in the series, has lavender eyes.
* Creator/JRRTolkien's ''TheLordOfTheRings''
** The villain Sauron, while not red-eyed himself, uses a red eye on black as his symbol.
** In ''TheTwoTowers'', the Műmak (giant elephant) who tramples the Ithilien Rangers and men of Harad is said to have raging small red eyes.
** In ''Literature/TheReturnOfTheKing'' chapter "The Scouring of the Shire" it says that Saruman's evil agent Wormtongue has red eyes.
* In the original picture book of ''MarsNeedsMoms'', Milo's mom (and I think Milo himself) have bright orange-red eyes. It doesn't mean anything but it does make TheReveal of [[TheFaceless Mom's face]] a little unnerving.
* Ares from the ''Literature/PercyJacksonAndTheOlympians'' books actually has ''[[NightmareFuel fire where his eyes should be]]''. Hestia is an aversion (as mentioned below).
* [[Literature/PeterPan Captain Hook]] had light blue eyes, but when he was angry, they would flash red.
* Creator/DeanKoontz's ''Literature/{{Phantoms}}''. When appearing to Jeeter and Kale in the cave, several of the monstrous forms that the incredibly evil Ancient Enemy takes have red eyes.
* In ''The Price'' by Creator/NeilGaiman, the main character realizes that the creature coming for them is the Devil because it has red eyes. While he's looking through night vision goggles.
* The ''Literature/ChroniclesOfPrydain'' novel ''The High King''. Gwythaints, the bird servants of the DarkLord Arawn, have blood-red eyes.
* In the ''Literature/RainbowMagic'' series, Storm the Lightning Fairy's book has an extra-mean goblin with red eyes. He shoots lightning at the girls with the power of the Lightning Feather.
* Hannibal Lecter of ''Literature/TheSilenceOfTheLambs'' is depicted with maroon (brownish-red) eyes in the books.
* The ''Series/StarTrekTheNextGeneration'' novel ''The Devil's Heart'' depicts [[TheCaptain Captain Picard]] with red eyes while holding the titular ArtifactOfDoom on the cover.
* Lin Carter's "Thongor of Lemuria" stories.
** The Grakk, a scaly flying lizard-like monster of the jungles of Chush, has cruel, scarlet eyes.
** The Dragon-Kings, who were the previous rulers of Lemuria before the humans came, have slitted red eyes. They were extremely evil and had great knowledge of sorcery and necromancy.
** The Gunth, extremely strong beastmen who lived in jungles, had gleaming red eyes.
* [[TheThrawnTrilogy Grand Admiral Thrawn]], a nonhuman Chiss who also had blue skin, had [[MonochromaticEyes solid red eyes]] that were [[WhatBeautifulEyes often said]] to be [[GlowingEyesOfDoom glowing]]. Even when he's solidly the antagonist, he is [[ALighterShadeOfGrey less evil and more ruthless]].
** [[XWingSeries Ysanne Isard]] actually had heterochromia, one eye being red, the other eye being blue. She's the head of Imperial Intelligence and decidedly evil.
*** The same series has the much more minor villain Zekka Thyne, who has red eyes and HellishPupils.
*** And it has two characters who each have a glowing red prosthetic eye. Neither of them are villains. One, Booster Terrick, is a smuggler who does not approve of the pilot his daughter fell in love with. The other, Ton Phanan, is an [[DeadpanSnarker incredibly sarcastic]] [[CombatMedic ex-doctor]] [[StepfordSmiler hiding the fact that]] [[CyberneticsEatYourSoul his extensive cybernetics cannot replace the future he lost.]]
* Creator/GeorgeRRMartin's [[Literature/TufVoyaging Haviland Tuf]] short story "A Beast for Norn". The ironfangs of the planet Lyronica are giant vicious wolf-like creatures with huge teeth and sunken red eyes.
* In the ''Literature/{{Twilight}}'' novel series, the vampires who drink only human blood have red eyes.
* The monstrous alien in Creator/JohnWCampbell's novella "Literature/WhoGoesThere" has three red eyes.
* Michael Stackpole's ''Wolf & Raven'' short story "Fair Game". The cyberdog that Selene Reece sends after Wolfgang Kies has eyes that look like red starbursts.
* Voidbringers in ''Literature/TheStormlightArchive'' are alleged to have red eyes, and we see at least one form of Voidbringer, a thunderclast, with glowing red eyes. Furthermore, in ''Literature/WordsOfRadiance'', [[spoiler: the Parshendi's eyes turn red when they transform into Voidbringers]].
* The plus-sized TyrannosaurusRex in ''{{Literature/Dinoverse}}'', who Mike names "Moriarty", is first seen with eyes that seem to glow red, though Mike thinks it's a trick of the sunset or a reflection of the blood at the dinosaur's feet.
[[/folder]]

[[folder:Live Action TV]]
* ''Series/{{Angel}}'': Lorne's got red eyes because he's a demon, but he's a gentle soul who's pretty sweet and fun company.
* The second Vorlon Ambassador in ''Series/BabylonFive'' has a red light in the "head" of his encounter suit, compared to the original Kosh's green. He's a [[DomesticAbuser much]], [[KnightTemplar much]] nastier person.
* ''Series/{{Battlestar Galactica|Reimagined}}'': Cylons. The single red flashing eye makes up a great deal of the Centurions' and Raiders' intimidation factor. Strangely, the only time we see a humanoid Cylon with red eyes, [[spoiler:it's Sam Anders, one of the good ones.]]
* ''Series/BuckRogersInTheTwentyFifthCentury'' episode "Space Vampire". The Vorvon's eyes glow red when it's using its MindControl powers on a victim.
* ''Series/BuffyTheVampireSlayer'':
** After [[spoiler: Tara is killed]], Willow looks up, and her eyes are glowing red. It's even lampshaded/foreshadowed by the episode's title, "Seeing Red".
** Red eyes are possessed by the First Evil's briefly-seen true form.
* ''Series/{{Charmed}}'': Used on Inspector Rodriguez [[spoiler: to confirm him as an upper-level demon]].
* When the placid "servant race" of Ood in ''Series/DoctorWho'' get red eyes, it's a sign that they've either been posessed by a {{Satan}}-like being from before the universe began or [[spoiler: simply overwhelmed by anger at the way they've been treated]]. Either way, it's bad news.
** Meanwhile, the only human that "Satan" managed to possess also gained blood-red eyes while the Beast was in control.
** Far earlier, those possessed by the similarly diabolical Fenric gained blood-red eyes, but only after they had faded from their initial shade of dark green.
** In the serial ''Robots of Death'', the eponymous robots' eyes are filled with red static when they prepare to kill.
** Similarly, the Siren from ''The Curse of the Black Spot'' turned not only her eyes, but the rest of her projected body from blue to red when anyone got between her and her victims.
* On ''Series/{{Farscape}}'', if a Delvian's eyes turn red, be moving in the other direction. It means they're going insane.
* On ''Series/{{Grimm}}'', we've seen Monroe's eyes turn red when he's upset, but not ready to go full GameFace in that situation.
* In ''HouseOfAnubis''once someone becomes a sinner, they obtain red eyes.
** It's worth mentioning that much of the time the person's eyes are normal color. It's only when they are feeling particularly evil that their eyes turn red, and even then it's merely for a second.
* Darien Fawkes of ''Series/TheInvisibleMan'' isn't evil, but he's prone to states of psychosis induced by the invisibility-causing gland in his brain; when he starts to flip out, his eyes go red. But when he gets to the point of no return, his eyes turn silver.
* Mituaki Gamou, the BigBad of ''Series/KamenRiderFourze'', has eyes that often glow red and was initially known as "The Red-Eyed Man" in promotional materials.
** Inverted with ''Series/KamenRiderKuuga''. Red Eyes Ultimate Kuuga is a GOOD thing as it shows Godai's good nature is shining through.
* In ''Series/{{Merlin}}'', Gaius realises that two visiting nobles are actually evil enchanters as he sees one's eyes flash red in a fit of anger. He really does take warning at the red eyes.
* ''Series/MightyMorphinPowerRangers'': Goldar's eyes are red and kinda glowy, Lord Zedd's visor is red, and the occasional monster has had red eyes.
* In an episode of the second ''Series/MissionImpossible'' series (1988), Mr. Phelps uses contact lenses that can glow red on command as part of a plan to convince his mark that he is the Devil.
* Davis Bloome on ''Series/{{Smallville}}'' gets these [[spoiler: when he's transforming into Doomsday]].
** Warrior Angel/Stephan Swift when [[spoiler:a curse turns him into Devilicus]].
* Randall Flagg in ''TheStand'' miniseries.
* ''Franchise/StarTrek'':
** In ''Series/StarTrekEnterprise'', the Na'kuhl (or, as they are better known, the "Red Eye Aliens" or "Evil Alien Nazis") all have red eyes, clinching them as candidates for the most evil-looking aliens in the history of fiction.
** Jake Sisko and, later, Dukat temporarily develop glowing red eyes while possessed by the Pagh Wraiths in ''Series/StarTrekDeepSpaceNine''.
** In the StarTrekTheNextGeneration episode called "Imaginary Friends" the titular girl, Isabella, gets red glowing eyes when she is upset when Clara leaves her at Troi's suggestion.
* ''Series/{{Supernatural}}'': Crossroads Demons. Other demons have similarly evil shades of white, yellow, or [[BlackEyesOfEvil black]].
* ''Series/TeenWolf'', Alpha werewolves' eyes turn red when they feel angry or predatory, even in human form. Once they shift, their eyes may glow outright. Also, Scott's yellow/gold eyes whenever he transforms.
* In the original ''Series/{{V}}'' series, the Visitors' true reptilian forms had red eyes.
* ''Series/TheXFiles'', episode "Detour": [[MonsterOfTheWeek MOTW]] creatures Moth Men had glowing red eyes. Very scary.
[[/folder]]

[[folder:Music]]
* Music/TheSweet's "Ballroom Blitz" mentions this about the man in back. "As a matter of fact, his eyes are as red as a sun." He's responsible for it turning into the titular ballroom blitz.
* Music/DavidBowie's "Film/CatPeople (Putting Out Fire)", written for the 1982 film, has a lovelorn man singing to an object of desire, warning her of the intensity of his need. The first verse establishes that his eyes are usually green, but they become red in the second verse:
--> ''See these eyes so red''\\
''Red like jungle burning bright''\\
''Those who feel me near''\\
''Pull the blinds and change their minds''
[[/folder]]

[[folder:Manhua]]

* [[CuteMonsterGirl Lilo I]], and probably every other vampire, in ''Manhua/{{Bloodline}}'' gets this once they drink someone's blood. This gives the showing that she's about to kick ass.

[[/folder]]

[[folder:Music Videos]]
* Music/{{Gorillaz}} bassist and MagnificentBastard Murdoc Niccals used to have one red eye and one black eye. The red eye appears to have turned black in recent pics, which may mean anything or nothing story-wise.
[[/folder]]

[[folder:Mythology]]
* The eyes of cemetery statue "Black Aggie" are said to glow bright red in the middle of the night, either blinding or killing anyone who looks into them ([[http://www.snopes.com/horrors/ghosts/agnes.asp source]]). One {{Urban Legend|s}}[=/=]CreepyPasta talks about a man who stays at a hotel but is told to stay away from a certain room. Out of curiosity, he peeps through a keyhole and sees an apparently normal room, with a woman sitting against a wall. When she moves, he backs away and returns to his room. Later, he tries looking in again, but he can only see something red through the keyhole. Not able to stand the questions any longer, he asks the hotel clerk what's wrong with the room. She tells him that, years ago, a couple died inside, and they tended not to mention it to avoid upsetting guests. [[spoiler:She also mentions that the couple had unusually red eyes]].
* The UrbanLegends creature known as [[http://en.wikipedia.org/wiki/Mothman Mothman]] is said to have glowing red eyes.
* Most people associate red eyes with DemonicPossession and TheDevil.
[[/folder]]

[[folder:Newspaper Comics]]
* These aren't a constant for any character in ''{{Candorville}}'', but [[spoiler:most vampires]] can activate and deactivate them at will. The only exception so far is [[spoiler:Saxon]], who gets [[spoiler:MilkyWhiteEyes]] either because of his [[spoiler:{{Dhampyr}}]] status or because he's a [[spoiler:FriendlyNeighborhoodVampire.]]
* ''ComicStrip/{{Garfield}}'''s art style usually doesn't allow for eye colors at all, but the infamous "abandoned house" sequence (beginning [[http://www.gocomics.com/garfield/1989/10/23/ here]]) has a close-up of one of Garfield's eyes in the final strip, red like blood, with the pupil contorted into a spiral as he refuses to accept what he sees.
** Another very early strip around Halloween, Garfield explains that around that time cats become bewitched. His eyes began to turn red among other things... that is until he saw himself in the mirror, screamed turned white and passed out.
* Al Capp's ''ComicStrip/LilAbner'' strip had the Nogoodniks, which were the evil version of the Shmoos. They were a sickly shade of green and had "li'l red eyes". They devoured "good" Shmoos, were the sworn enemies of "hoomanity," and wreaked havoc on Dogpatch.
[[/folder]]

[[folder:Other Sites]]
* ''Wiki/SCPFoundation'', [[http://www.scp-wiki.net/scp-1111 SCP-1111 ("The White Dog")]]. The title ghostly animal has red eyes that glow more brightly the closer it is to its point of origin. It savagely attacks all human being that approach it.
[[/folder]]

[[folder:Pinball]]
* The antagonist in ''Pinball/{{Centaur}}'' has small red eyes, as if his bestial face, inhuman form, and dominatrix-inspired design didn't raise enough warning flags.
* Similarly, the monstrous ''Pinball/{{Varkon}}'' has round red eyes, which combine with his small fangs and rounded, brutish face to complete his MonstrousHumanoid appearance.
[[/folder]]

[[folder:Tabletop Games]]
* ''All the Worlds' Monsters'' supplement by Chaosium.
** The ChaoticEvil Coachman of Death and his horse have glowing red eyes.
** The Lesser Demon has glowing red eyes.
** The Night Hound, which hunts down and kills all Lawful beings, has red eyes.
** The Evil undead Lemure monster has glowing red eyes.
** The powerful and dangerous Three Horsemen of Doom all have flame red eyes.
* Arduin Dungeon #2 ''The Howling Tower'' has a deadly steel tiger monster with red eyes.
* ''TabletopGame/ArsMagica''. Brude Deathless, the oldest and most powerful gruagachan in all Scotland, has a terrible temper and loves to put curses on anyone who annoys him. His eyes turn red when he gets angry.
* ''Atlantis: The Lost World'' generic RPG setting. Wraiths (which are based on Creator/JRRTolkien's Ringwraiths/Nazgűl) have two glowing red eyes that are hidden in shadow. Bat Horins are lesser devils whose eyes radiate an eerie crimson luminescence.
* ''TabletopGame/BloodOfHeroes''. Both the supervillain Lord Bane and his horse Hell's Mount have glowing red eyes.
* ''TabletopGame/CallOfCthulhu'':
** Deities: Atlach-Nacha (Great Old One), the Haunter of the Dark (avatar of Nyarlathotep), Ithaqua.
** Monsters: Black Unicorn of Averoigne (''Worlds of Cthulhu'' #3, "Dark Ages Averoigne"), Bunyip (''Terror Australis''), ghouls (glowing red, ''Shadows of Yog-Sothoth'' adventure "The Warren"), Necromantic Skeleton (''The Asylum and Other Tales'' - "Black Devil Mountain"), Proto-Shoggoth (''The Asylum and Other Tales'', "The Asylum"), rats (''Masks of Nyarlathotep'' - Kenya section), Spectral Hunters, The Thing from Between the Planes (''The Fungi from Yuggoth''), Undead Sorceress (''Dreamlands'' adventure "Pickman's Student"), Werewolves (''Worlds of Cthulhu'' magazine #3, adventure "Malevolence").
** Supplement ''Dark Designs'', adventure "The Menace from Sumatra". Vibur (AKA The Thing from Beyond) has three triple lobed burning red eyes.
* ''Carcosa: Weird Science-Fantasy Horror Setting''. In hex 0814 is a Spawn of Shub-Niggurath of Chaotic alignment (worships and serves the extremely evil deities of the CthulhuMythos). It has a single red eye.
* ''{{Champions}}''.
** In the supplement ''Enemies II'' the supervillain The Monster has glowing red eyes.
** In the adventure ''Deathstroke'', the supervillain Doctor Death wears an armor suit with a deep red light coming from his eye sockets.
* Mayfair's ''Chill''. Evil game monsters that have red eyes: Barghest, Ghoul, Hook Thaggis, Spectral Hound, Werewolf (wolf form).
* ''Chivalry & Sorcery'' 3rd Edition adventure ''Stormwatch''. Kobolds living in a copper mine have been kidnapping, killing and eating human miners and other villagers. They have ruby red demon eyes, red as sparks and hellfire.
* ''DangerousJourneys[=/=]Mythus'', ''Journeys'' magazine issue #2. In the adventure "It's Never a Good Day to Die", the evil necromancer Horace Quintell has eyes that burn with an intense redness.
* ''TabletopGame/DungeonsAndDragons'':
** Most versions of drow or dark elves have red eyes. They are AlwaysChaoticEvil and the [[MySpeciesDothProtestTooMuch exceptions]] inevitably have other eye colors such as violet or yellow. They all have red eyes in deep darkness, however. It's part of their darkvision.\\
\\
Interestingly, the original incarnation of drow as presented in the modules in which they made their first appearance were described as having amber or yellow eyes. It was only in later developments that they were described as red-eyed, possible a case of {{Fanon}} due to the misconception that the heat radiance of thermal imaging organs (or ultraviolet imaging organs) appear red to normal vision.
** Some 1st/2nd Edition evil monsters with red eyes: babau demon (ChaoticEvil), cloaker (attacks and kills victims), cockatrice (turns victim to stone), giant strider (NeutralEvil), guardian daemon (kills anyone who approaches), harginn grue (NeutralEvil, "glow dark red"), hellcat (LawfulEvil), ildriss grue (NeutralEvil, "faintly gleaming red"), kobold (LawfulEvil), medusa (LawfulEvil), night hag (NeutralEvil), nightmare (NeutralEvil), tasked slayer genie (NeutralEvil), yeth hound (NeutralEvil), the demon lord Juiblex (ChaoticEvil), and the Nehwon god called Hate (ChaoticEvil). Mystaran examples include the gator men (ChaoticEvil), iron gargoyles (extremely dangerous), saberclaws (LawfulEvil), werejaguars (in jaguar form, ChaoticEvil), and yowlers (ChaoticEvil).
** 3rd Edition:
*** ''Monster Manual'': nalfeshnee (Type IV) demon, drow, gorgon, hell hound, salt mephit, skeleton, wraith, half fiend, lich, lycanthrope in animal form.
*** ''Creature Collection'': Ratmen/Slitheren (all types have red, beady eyes)
** Kara Tur (Oriental Adventures) modules
*** [=OA5=] ''Mad Monkey vs. Dragon Claw''. The ChaoticEvil vampiric ningyo (mermaids), two Dragon Claw warriors the {{PC}}s kill, and the giant Dragon Claw statue after it's animated.
*** [=OA6=] ''Ronin Challenge''. The powerful LawfulEvil Earth Spider and its minions (goblin spiders, giant spiders, and bakemono) all have red eyes.
*** [=OA7=] ''Test of the Samurai''. Bokika Hokio, the LawfulEvil 16th level samurai daimyo of Fochu province, has fiery red eyes and an explosive temper. The krakentua monster is ChaoticEvil, 80-100 feet tall, looks a lot like [[CthulhuMythos Cthulhu]] and has red eyes.
** Module X2 ''Castle Amber''. In the Indoor Forest, the master of the Wild Hunt (Andrew David Amber) has glowing red eyes.
** Basic D&D
*** Module O2 ''Blade of Vengeance''. Gorkalk, the great grandfather of the ChaoticEvil red dragon Khordarg. It may be that all red dragons in Basic D&D had them.
*** Module B8 ''Journey to the Rock''. The ghostly horsemen of the ruined city of Tuma have eyes that are dull red, like a dying fire.
** 1st Edition module I12 ''Egg of the Phoenix''. The LawfulEvil wererats in the "Crypt of Empyrea" adventure have red eyes. This was not stated in the 1st Edition ''Monster Manual'' entry on wererats.
** TabletopGame/{{Ravenloft}} module [=RA1=] ''Feast of Goblyns''
*** When the {{PC}}s encountered a barrier made of skeletons, each skeleton had eyes that burned with a cold, red light.
*** A giant skeleton had pinpoints of red light in its eyes.
*** After Radaga's body was possessed by Daglan, she had cold, red light burning in her eyes.
*** Goblyns had glowing red eyes.
*** Greater wolfweres. In all forms except human, their eyes glowed red in the dark.
** TabletopGame/{{Ravenloft}} module ''Death Ascendant''. After the creature known as Death is created, it has glowing red eyes.
** TabletopGame/{{Ravenloft}} campaign expansion ''Masque of the Red Death'', adventure "Red Tide". Dracula has glowing red feral eyes.
** TabletopGame/{{Ravenloft}} [=RQ3=] ''From the Shadows''
*** The {{PC}}s are sent back in time to when Strahd von Zarovich was changed into a vampire. After the conversion the ChaoticEvil Strahd is stated to have glowing red eyes, a dead giveaway to the fact that he's now a supernatural creature.
*** Azalin's phylactery takes the form of a huge 200 pound gold-plated dragon skull. Its eyes are rubies and an ever-burning flame is in its mouth, giving the eyes a dull red glow similar to that of the LawfulEvil lich it is magically linked to.
** DarkSun boxed set [=DSE1=] ''Dragon's Crown''.
*** Booklet "Out of the Valley". The {{PC}}s' nemesis Avegro appears in dream form with eyes "like pits of crimson flame", and later on, the {{PC}}s encounter a ghast with glowing red eyes.
*** Booklet "The Road of Fire". A wraith (undead monster) the {{PC}}s meet has glowing red eyes.
** DarkSun ''Monstrous Compendium Appendix: Terrors of the Desert''.
*** The dwarven banshee. The pupils of this dangerous undead creature's eyes flicker red as if a flame burns them from within.
*** Greater Fire Elemental. It can do up to 40 HitPoints of damage per combat round, and its eyes glow an intense bright red.
*** The ChaoticEvil Nightmare Beast, one of the most feared monsters on Athas. They have large red eyes that glow in the dark.
*** The Sand Bride is a ChaoticEvil monster that drains LifeEnergy and has glowing red eyes.
*** The ChaoticEvil So-ut (Rampager) has glowing red eyes.
*** The NeutralEvil T'Chowb has beady red eyes. It can permanently drain a creature's intelligence by touch.
** DarkSun ''Monstrous Compendium Appendix: Terrors Beyond Tyr''.
*** The boneclaw baazrag has red eyes that glow in the dark.
*** The Dune Reaper has eerie, luminescent red eyes.
*** The Magma Paraelemental Beast has fiery red eyes.
*** The Obsidian Retriever has six red eyes.
** ''Magazine/{{Dragon}}'' magazine
*** Issue #25 article "Varieties of Vampires". The Ch’ing-Shih vampire from China has red, staring eyes.
*** Issue #51 story "A Part of the Game''. A monster that used its YourHeartsDesire ability to lure 12 men to their deaths has "two red eyes burning like coals in a brazier in the Hall of Pain."
*** Issue #93 article "Nine Hells Revisited". The powerful LawfulEvil greater devil Malarea has fiery red eyes.
*** Issue #142 "Ecology of the Kech". The NeutralEvil keches have blood-red, pupil-less eyes. They are extremely evil and rapacious, considering all other creatures (including humans) to be food. They love to set up traps to catch victims.
** Al-Qadim boxed set ''A Dozen and One Adventures''. The black idol in Al-Anwhar has two ruby eyes that glint malevolently. If the {{PC}}s touch the eyes, they can be {{Mind Control}}led into sacrificing themselves to the idol.
** The ''Advanced TabletopGame/DungeonsAndDragons Coloring Album'' mentioned a NeutralEvil lich with "eye sockets gleaming fiery red".
** ''World of TabletopGame/Greyhawk Fantasy Game Setting'' boxed set (1983) "Glossography" booklet, adventure "The Lost Passage of the Suloise". The title passage is guarded by a huge monster with glowing red eyes (which are actually gems) left by the LawfulEvil Suloise. If it catches a victim it will crush them flat.
** Mayfair Games' Role Aids supplement ''Dark Folk''
*** The ChaoticEvil gnoll deity Xyrmgnollven has blood red eyes.
*** The LawfulEvil goblins have glowing red eyes.
** In the ''Deities & Demigods Cyclopedia'', in the CthulhuMythos section the LawfulEvil Primordial Ones had five red-irised eyes.
* ''{{GURPS}}'':
** ''Fantasy Folk''. Minotaurs have the disadvantages Berserk, Bloodlust, Intolerance, and Savage. They're aggressively antisocial and eat other sentient creatures. They also have red eyes.
** ''Franchise/{{Conan|TheBarbarian}}: Moon of Blood''. The swamp devils have eyes as red as coals of living fire, and the chaken (ape men) have flaming red eyes.
* ''ComicStrip/KnightsOfTheDinnerTable'' #168 "Bait & Tackle" section (adventure seeds). In "Puppetmasters", the inhabitants of a small village develop red eyes when they're possessed by demons.
* ''TabletopGames/LejendaryAdventures''
** The hobgoblins known as Nis carry out raids: looting, pillaging and taking slaves. They have slanted red eyes.
** Ulfs are the most vile type of Alfar, even more terrible than ogres. They like to cause misery, suffering, disaster and lingering death. They have glittering red eyes.
* ''TabletopGame/MagicTheGathering'' has [[http://www.wizards.com/Magic/TCG/Article.aspx?x=magic/bok/inkeyes Ink-Eyes]], a rat ninja with BlackEyesOfEvil that look like they're [[GlowingEyesOfDoom on fire]]; this is the result of her [[DealWithTheDevil deal with Kuro]] to make her more powerful. Kuro also has three red eyes.
* ''TabletopGame/{{Paranoia}}'' adventure ''Send in the Clones''. The rats in the Sewerworld adventure have beady red eyes.
* ''TabletopGame/{{Shadowrun}}'' supplements:
** ''Paranormal Animals of North America'':
*** The Firedrake and Icedrake (both dangerous carnivores) have red, malevolent-looking eyes.
*** The Gyre (Awakened form of the common turkey vulture) has red eyes. It will attack weak or wounded animals, including humans.
*** The Hell Hound has red-rimmed eyes, and the ''Awakenings'' sourcebook clarifies that their eyes are fiery red.
*** The Novopossum has red eyes and acidic saliva. It can fight ferociously when it needs to.
*** The Siren (looks like a small pterodactyl) has red eyes. It is a ferocious predator that attacks and kills humans.
*** The Snow Snake has red eyes that glow in the dark and a poison bite that can kill a human being in seconds.
** ''Paranormal Animals of Europe'':
*** The Kludde is a shapeshifter that uses its powers to weaken and terrify its prey (including humans) before killing them. It has red corneas in all of its forms.
*** The spirit horses ridden by members of the Wild Hunt have red eyes. They can breathe fire and expel a noxious breath that can render an opponent unconscious.
** ''Sprawl Sites''. An apparent vampire who attacks the {{PC}}s with spells has red eyes.
** ''Native American Nations Volume 1'':
*** When the (evil and insane) toxic Rat shaman Jesse Johns uses magic, his eyes take on a red tinge.
*** The decker Ram's icon in the Matrix is a huge, black-furred humanoid with glaring red eyes.
** ''Critters''. The chupacabras has large red eyes. It feeds on blood and Essence, attacking metahumans in remote areas with its paralyzing touch.
** ''Denver: The City of Shadows'' boxed set. The decker named Bash has a Matrix icon with gleaming red eyes. He exists in a permanent state of barely suppressed rage.
* ''{{Rolemaster}}'' ''Shadow World''
** The campaign setting: Wraiths, Wild Hunt hounds, Zephyr Hound - Fire (glowing red), Demons of the Sixth Pale (glowing red), the Dragonlord Oran Jatar, Black Unicorns (glowing red), the Heralds of Night (glowing red) and the Dark Gods Orgiana (glowing red), Z'taar (luminous red), and Scalar (luminous red).
** ''Quellbourne: Land of the Silver Mist''. Trolls have deep-set red eyes.
** ''Demons of the Burning Night''. The following monsters/opponents have red eyes: Flete Demons, the greater evoker demon Teroglustrod The Red Gate and the half-demon General Mortilas.
** ''Journey to the Magic Isle''. The lich Balizaar, the deadly and evil enemy of the University of Magical Arts, has glowing red eyes.
** ''Jaiman: Land of Twilight''. Black trolls (AKA War trolls) are dangerous, fearsome and cruel [[ImAHumanitarian man-eaters]] that have evil red eyes.
* ''Space Gamer Fantasy Gamer'' magazine #7:
** Article "Villains Finish First!". The super villain Gloom has blood-red eyes.
** Article "Barony - A Tale for a Bored Court". In Barony, dwarves are base, evil creatures which have strange red eyes.
* ''Franchise/StarTrek The RPG'' (FASA) adventure ''Orion Ruse'':
** The BigBad Markos Keras has dark red eyes, unusual for an Orion. His servants think they give him supernatural powers. He has a fierce temper, is rash and impetuous, and is likely to try to have the {{PC}}s killed.
** Alien animals called Slethi have teeth that inject a venom that causes intense, immobilizing pain and ultimately leads to death. They also have bright red eyes.
* ''TabletopGame/{{Stormbringer}} Companion'' supplement by Chaosium.
** The Golden Icehound has eyes of red demon-fire.
** Adventure "Hall of Risk". The demon lord Baaleer has burning-red eyes.
** Adventure "The Crystal of Daerdaerdarth''. The demon guardian Trunchuss has red eyes.
* ''[=TimeLords=]'' adventure ''Supertanker of Death''. The genetically engineered man-eating walrus Fang has red eyes.
* ''TabletopGame/TunnelsAndTrolls'' Solo Dungeon #4 ''Naked Doom''. In one room the {{PC}} will be attacked without warning by a rock troll in a fight to the death. Rock trolls have piggish little red eyes.
* ''VillainsAndVigilantes'' adventure ''Devil's Domain'':
** On Easter Island a villain has 4 statues with eyes that "smolder evilly red''.
** The Daven and Abomination demons have red eyes.
* The entire ork race in ''TabletopGame/{{Warhammer 40000}}'' has evil red eyes. The warning part however usually comes from a mountain of weapon wielding green muscle charging you. Besides, the eyes are quite sunken and difficult to see unless you're up close and suicidal.
** Or unless it's dark. The 3rd edition Ork Codex featured cover art of a greenskin mob charging a trench during a thunderstorm. The Orks in the foreground were well-lit, while all the ones beyond were just hulking shadows with tiny glimmers of red glaring out at you.
* ''Witch Hunter: The Invisible World''.
** The monstrous black hounds that roam the English countryside and attack travelers have glowing red eyes.
** The vampires known as Apotamkin have blood red eyes.
* ''It Came from the Late, Late Show II'' adventure "Bjorn on the Bayou, or Escape from Alkatrazz XII". Alkatrazz XII is a prison planet. Warden Skrank is corrupt, sadistic, and a cyborg with a blinking red robotic right eye.
[[/folder]]

[[folder:Toys]]
* Zigzagged in ''Franchise/{{Bionicle}}''. As a general rule, the color of the eyes can be used as an indication for "good or evil", but you have to ask yourself how the eyes fit with the armor.
** In the movie ''Bionicle: Web of Shadows,'' Toa Vakama inverts this: he has red eyes ''until'' he goes over to TheDarkSide, at which point, his eyes turn [[SicklyGreenGlow green]]. His toy, on the other hand, always had green eyes.
** The evil Roodaka from the same movie had blue eyes as a standard, but when she got really angry, they turned bright orange/red.
** And naturally, the original BigBad, Makuta Teridax, also had his trademark red eyes (which he liked to project into shadowy corners), as did many of his brethren, as well as some other villains in the toyline (Krekka, Sidorak, Piraka, Keelerak spiders, etc.). Some, however, eventually substituted orange for red, when the eye colors became ColorCodedForYourConvenience. Generally speaking, though, the eye colors of the Bionicle characters were all over the place, especially in the earlier years.
[[/folder]]

[[folder:Video Games]]
* [[spoiler:Shih-na]] has these in VisualNovel/AceAttorneyInvestigationsMilesEdgeworth.
* In ''VideoGame/AdventureQuestWorlds'', Chaos Dragonlord Vath's eyes are normally purple, but when his BerserkButton is pressed, causing him to [[VillainousBreakdown lose his cool]] after he finds out that the hero freed the dwarves and they are winning against his army, guess what color they turn...
* In ''VideoGame/AnarchyReigns'', Jack's eyes will turn red whenever he gets really angry (and he's already pretty bitter most of the time).
* Jake's eyes change to red when he is being controlled by Specter in ''VideoGame/ApeEscape''. Also, Specter's eyes change when he dons the Peak Point Helmet and uses his newly gained augmented intelligence to try and take over the world by changing history.
* Lieselotte Achenbach, the EnfantTerrible from ''VideoGame/ArcanaHeart'', has red eyes and is nicknamed "The Crimson-Eyed Criminal", as she's an emotionally scarred assassin. She also has white hair. She'd fall under EvilAlbino if she were just a bit more pale.
** Also, the BigBad Mildred when she absorbs the [[AllYourPowersCombined power of the Elementals]] and [[AGodAmI becomes an Archangel]].
** Clarice di Lanza, a [[NunTooHoly nun who is also a demon]], usually falls under the EyesAlwaysShut trope and is, for the most part, good natured...unless you do something to seriously anger her, at which point her eyes open and this trope is in full effect.
* Asura from ''AsurasWrath'' has natural brown eyes. But when he crawls out of Naraka for the first time, his eyes become glowing white orbs with red-white pupils, and he's ''pissed''. At the very end of the final DLC chapter, when [[spoiler: Chakravartin is slain and his wrath is finally gone, Asura's eyes revert to their original brown color before he fades away.]]
* In both ''Franchise/{{Bioshock}}'' games, the [[GiantMook Big Daddies']] eyes turn from yellow to red when they see an enemy. When you see those red eyes, you best get out of there. Same goes if you hear [[DynamicEntry "HEUUUUUUUUUUUUUUUUUUNGH!"]]
* Caleb, the undead asskicker and protagonist from the first-person shooter ''VideoGame/{{Blood}}'', has permanent, glowing red eyes.
* When Vivi is prepared for a VampiricDraining of Lance in one death scene of ''VideoGame/BrainDead13''.
* ''Franchise/{{Castlevania}}'' series usually depicts Dracula as having Red Eyes, and in ''Portrait of Ruin'' -- the twins Loretta and Stella both have one red eye, and Brauner also has red eyes. [[spoiler: The twins' heterochromatic eyes is to show that they are under Brauner's sway but they are still able to be turned back to humans, losing the red eye when they do]]. However, other vampires such as Elizabeth Bartelby, Carmilla, etc. aren't shown with red eyes, so it's not a guaranteed Vampiric trait.
** Soma gets the red eyes in ''Dawn of Sorrow'' if he loses himself to his SuperpoweredEvilSide.
* The Praetorian Police in ''CityOfHeroes: Going Rogue'' occasionally say this, "Its eyes glowed red. That's all I need to take the safety off."
* The [[EliteMook Black Phantoms]] of ''DemonsSouls'' have red face orifices, which should tell you that they are much, ''much'' more powerful than your enemies up to that point and you should consider going back the way you came.
** There's also a non-Black Phantom mook in the first non-tutorial level called the Red Eye Knight. Players that don't know what they're getting into often die within seconds of provoking him. BossInMookClothing indeed.
** If the eyes of the Dragon God boss turn red, start running and don't stop until you're behind a pillar or other large visual obstruction, unless you like the idea of a fist larger than you are smashing you through a granite wall.
* Dante from ''VideoGame/DevilMayCry'', before he [[CurbStompBattle goes to town]] on Mundus. Twice for Nero in [=DMC4=], the first time when he gains his Devil Trigger, and the second [[spoiler: when Angelo Agnus escapes with Kyrie and leaves Nero to vent his rage out on some {{Mooks}}]].
* Naoya in ''VideoGame/DevilSurvivor'' has red eyes. He's about as nice as this trope suggests. They're extra-distinctive in that he's one of the few characters who doesn't invoke CurtainsMatchTheWindow.
* Most of the protagonists in ''Franchise/{{Disgaea}}'' thanks to being all demons. [[spoiler: [[VideoGame/DisgaeaHourOfDarkness Angel trainee Flonne]] even gets red eyes when she [[FallenHero falls]] from the ranks of the angels at the end.]]
** The exception to this is Adell in [[VideoGame/Disgaea2CursedMemories the sequel]], who is blue-eyed. Amusingly enough, his actual character model in-game is red-eyed as well -- [[spoiler:which would be more appropriate, seeing how he is also a demon. Then again, [[ClapYourHandsIfYouBelieve his belief in his own humanity is apparently so powerful that no-one else can tell anyway.]]]] The red color could also be the result of his hair being over his eyes in his sprites. Yukimaru also has blue eyes.
* ''VideoGame/{{Doom}}''. The Spider Mastermind (AKA Spiderdemon) has glowing red eyes. It also has a chaingun that will chop you to pieces if you give it a clear shot at you.
* VideoGame/DragonAgeII: despite the image above, [[TrailersAlwaysLie Hawke never gets these]]. However, [[spoiler: [[KnightTemplar Meredith]] does, after taking possession of a certain ArtifactOfDoom stolen from the player and forging it into an EvilWeapon.]]
* Psaro the Manslayer from ''VideoGame/DragonQuestIV'' has red eyes, which give him his evil image.
** In the official ''VideoGame/DragonQuest'' arcade game, Monster Battle Road series, one of the special attacks which features him reveals him with glowing red eyes.
* TheEvilArmy in ''{{Drakengard}}'' initially seems to have these, but, later on, cutscenes demonstrate that they are really MindControlEyes. The trope is played straight with Manah, the BigBad. There's a bit of FridgeLogic here in that her identical twin brother has green eyes.
* ''Franchise/TheElderScrolls'':
** Shadowmere in ''VideoGame/TheElderScrollsIVOblivion'' and ''VideoGame/TheElderScrollsVSkyrim.'' The most badass CoolHorse in the game. Astrid, who gives you Shadowmere, never really tells you what the horse actually ''is,'' but Shadowmere is tougher and heals faster than all other horses, and is also extremely aggressive, and will happily take on ''dragons.''
** In ''VideoGame/TheElderScrollsArena'' this is ''definitely'' part of Jagar Tharn's Evil Sorcerer-style, though in-universe the red eyes only marks him as suspect to racists (it marks him as having Dunmer somewhere recent in his ancestry).
** The Dunmer themselves zigzag this. Individual dark elves can be as good or as evil as anyone else, but according to legend their coloring, including the red eyes, was a punishment by the Daedric Prince Azura for the Tribunal's betrayal of Nerevar.
* In ''VideoGame/{{Fable}}'', you can get glowing red eyes if you're evil enough.
* ''FinalFantasy'':
** ''VideoGame/FinalFantasyIV'':
*** Played with. While [[HeelFaceRevolvingDoor Kain]] does have red eyes, due to his [[HiddenEyes helmet covering the top half of his face]], we only see his eye color ''after'' his final FaceHeelTurn and GoodCostumeSwitch in the sequel.
*** The DS version of the game gives this trait to the Antlion. When its eyes are normal, it counters physical attacks, but when they turn red, magical attacks are countered instead.
** Terra's [[spoiler:(in-game) Esper form]] in ''VideoGame/FinalFantasyVI'' has these--though this trope is later subverted.
** In its dormant state, Jenova from ''FinalFantasyVII'' resembles an albino woman with glowing red eyes, and a lifeless, fixed leer on its face.
** Adelle from ''VideoGame/FinalFantasyTacticsA2'' had these eyes when she was in Illua's influence. Illua herself has these eyes too, later in the game.
** In the 2006 trailer for''VideoGame/FinalFantasyXV'' Noctis' eyes glow red when using his powers.
* ''FireEmblem'' has a lot of bad guys with glowing red eyes. [[spoiler:Berserk Ashnard, Yurius, Hardain, and the feral ones, to name a few.]]
* In the first ''[[VideoGame/FirstEncounterAssaultRecon F.E.A.R.]]'' game, [[CreepyChild Alma's]] eyes were hidden by shadows and her hair, but in ''Project Origin'', they are visible, and glow a dull red.
* [[http://cutstuff.net/blog/?page_id=1522 The Jitterskull]] from ''VideoGame/GhoulsVsHumans''. "The eyes were blacked out and little red circles were added because we all know that red eyes are EVILLLL."
* The Fire Clan in ''VideoGame/GoldenSun'' games, who show up consistently in the first two games as powerful and dangerous antagonists, [[spoiler: [[AntiVillain even if they are actually trying to save the world]]]]. Blados in ''Dark Dawn'' is a CardCarryingVillain with this trope in full effect.
* In ''VideoGame/HalfLife1'', the [[BossInMookClothing Gargantuan]]'s eyes would turn from yellow to red when they saw an enemy.
** Not always red, but Combine soldiers in ''VideoGame/HalfLife2'' tend to have glowing eyes.
*** To specify, the [[CyberCyclops Overwatch]] {{Elite|Mooks}} soldiers have a [[CyberCyclops large red eye]], and Overwatch soldiers with shotguns sort of apply, with reddish-orange eyes.
*** They definitely apply; the shotgun wielding Overwatch soldiers are (some of) the most lethal enemies in the game if you stumble across them in close range, so you really should [[InvokedTrope take warning]] when you see their red eyes bearing down on you.
** Also, in ''Half-Life 2'' GameMod ''VideoGame/{{Dystopia}}'', Corps have glowing blue eye. Punk heavies have red eyes. [[http://www.dystopia-game.com/pr_images/070117/weapons.jpg Pictures here.]]
* ''Franchise/{{Halo}}'': 343 Guilty Spark's eye turns red when he becomes Rampant. His EyeBeams turn red as well.
** [[spoiler: When the [[{{Halo 4}} Didact]] undergoes procedures to acquire Flood immunity, his eyes turn from grey to a hellish red-orange. He begins acting a little unhinged (possibly as a side affect of the failed procedures), culminating in attempting to harvest humanity into his personal Flood-fighting robotic army.]]
* EvilOverlord Baron Praxis and VillainousGlutton Krew from ''JakIIRenegade'' both have red eyes -- or actually, one each. Subverted with the monk Seem, introduced in ''Jak3Wastelander'', who is hostile at first, but turns out to be benevolent and becomes an ally.
* This is your only warning before you are about to get ''mauled'' by [[spoiler:a war machine]] in ''{{VideoGame/Journey}}''.
* Kun Lan in ''{{killer7}}'', as part of being an EvilAlbino.
* In the ''{{Killzone}}'' series, the Helghast have a "Red eyes" appearance caused by their masks worn in battle, not too differently from the Combine in ''Half-Life 2: Episode 2''.
* Dark Matter from ''VideoGame/{{Kirby}}'', with the prominent ones being their leader, Zero, who rips his own eye out in his debut, and Miracle Matter, who has 20 of them.
** It's worth noting that, in all his forms, as well as his Mirror Land counterpart Dark Mind, Dark Matter is ''nothing but'' a giant red eye or some form of one.
* In ''VideoGame/Left4Dead'', the Witch is distinctive (and sometimes visible only) by her glowing red eyes. Startling her, thus invoking her wrath, is a ''really bad idea.''
* In ''Franchise/TheLegendOfZelda'' series:
** Ganon usually has glowing, red eyes.
** Vaati also has red eyes, and he's the BigBad for three games.
** Dark Link often has (glowy) red eyes and is always an antagonist.
* Played with in VideoGame/LoveAndWar. Lavender Regale is a bright, cheerful GirlNextDoor, but she has also has a [[{{Tsundere}} violent temper]]. When she's about to lose it, her eyes turn red. Ryan, the protagonist, [[LampshadeHanging lampshades]] the usual usage of this trope by jokingly referring to her as "the she-devil, Lavie" whom only "the Holy Paladin, Ryan Eramond" can defeat.
* The goddess Althena develops [[MostCommonSuperpower a nice pair]] when she kicks off the end of the world in ''[[{{VideoGame/LunarTheSilverStar}} Lunar: Silver Star Story]]''. Oh, and her eyes glow red too, I guess.
* In ''[[VideoGame/MarioAndLuigiPartnersInTime Mario & Luigi: Partners in Time]]'', the Shroob, including the Princess [[spoiler:and her elder sister]], have red eyes.
** In ''VideoGame/MarioAndLuigiDreamTeam, both the gardening robot Grobot and the later defence system boss Pi'illodium having ominous glowing red eyes. The former to indicate it's broken and gone insane, the latter just to show it's evil and currently at full power (its eyes temporarily turn blue whenever its wings are destroyed and its defences weakened).
* ''VideoGame/MassEffect2'' has Shepard, the protagonist, who - if you play him/her as a violent renegade - gets eyes that glow red. This is due to an aftereffect of the Lazarus project: at the start of the game, you are recently brought BackFromTheDead and have scars on your face and cybernetic ocular implants. If you play as a [[TheParagon Paragon]], they heal over time; whereas if you play [[SociopathicHero Renegade]], the red glow in Shepard's eyes becomes more pronounced, along with [[GoodScarsEvilScars the scarring]]. Regardless of the alignment, however, you have an option to purchase an expensive upgrade to you medical bay that permanently heals the scars, after which your Paragon/Renegade actions will stop affecting your face.
* Forte from ''VideoGame/MegaMan'' (Bass in the English version) has these.
** In ''VideoGame/MegaManZero'', Copy X has these as [[KnightTemplar just one more sign that he's not quite...right]].
** In ''MegaManZX'', this is a common side effect of being under the influence of [[ArtifactOfDoom Model W]]. Master Albert takes it to the next level by combining it with BlackEyesOfEvil.
* In ''Videogame/MetalGearRisingRevengeance'' enemies quite literally have glowing red eyes before they attack, signaling danger. Also, Raiden has one red eye, particularly visible in the main menu of the game.
* Some monsters in the ''VideoGame/MonsterHunter'' franchise have them. The most notable being the Nargacuga, whose eyes turn glowing red when in rage mode.
* In the SegaSaturn game ''VideoGame/MrBones'', [[DemBones skeletons]] reanimated with evil skeletism have red eyes, with the main character having blue eyes to signify that he's good. BigBad [=DaGoullian=] also has red eyes, and [[HaveANiceDeath losing all your health shows a cutscene of the title character's eyes turning red]].
* Subverted in ''VideoGame/NeverwinterNights2'' with Neeshka. Her red eyes are courtesy of having a [[OurDemonsAreDifferent pit fiend]] for a grandfather, and tieflings such as her have a tendency towards evil because of their fiendish heritage. However, Neeshka is quite friendly and is at worst a {{Kleptomaniac Hero}}ine, [[spoiler:and can only turn against you because of a {{Geas}} placed on her by TheDragon when he captures her in the endgame. She can even break free of it if your RelationshipValues are high enough.]]
* In ''[[NintendoWars Days of Ruin]]'', you have the MadScientist EvilAlbino Caulder/Stolos.
* In ''VideoGame/SengokuBasara'', the DemonKingNobunaga has glowing red eyes when tapping into the power of Hell. The anime made them permanently red, and the same for his successor UsefulNotes/ToyotomiHideyoshi. UsefulNotes/IshidaMitsunari is a similar case, as his pupils flash red when he's enraged.
* Elena in ''VideoGame/PandorasTower'' has these, but it's a subversion; her eyes seem to be reddish normally, but turn blue whenever she's in the later stages of the curse [[BodyHorror turning her into a monster]].
* Inverted by Labrys in ''VideoGame/Persona4Arena''. When her eyes are red, she's a friendly ClassRepresentative. However, when her [[EnemyWithout Shadow]] has SupernaturalGoldEyes, and when Labrys is mind-controlled, her eyes turn a [[MindControlEyes dull gray]]. It's played straight though by the [[EnemyWithout shadow selves]] of the heroes in ''VideoGame/{{Persona 2}}''
* Silver, your ''Franchise/{{Pokemon}} GSC'' [[TheRival rival]], gets these in the sequel [[CurtainsMatchTheWindow to match his hair.]] Nevertheless, he's a {{Jerkass}} before his HeelFaceTurn.
** Ariana, the Team Rocket Admin from the same games, also has these.
** On the subject of ''Pokémon'', we have Cipher Admin Nascour, who happens to be Master Albert's predecessor with the whole black sclera red iris schtick. He just happens to be [[ObviouslyEvil the face of the most evil Pokemon crime syndicate]].
** Ghetsis, a member of Team Plasma from VideoGame/PokemonBlackAndWhite, takes this trope to new extremes - he has one natural red eye, a {{glowing|EyesOfDoom}} red monocle, and a red eye printed on each sleeve of his robe. [[spoiler: It becomes fitting as more of his actions and intentions are revealed.]]
** Beedrill, [[EverythingsWorseWithBees a giant, poisonous, territorial hornet.]]
** [[{{Kitsune}} Ninetails.]] It can control minds with said eyes. It's also extremely vindictive, going so far as to curse people for 1000 years for daring to grab one of its tails.
** The Rhyhorn line. While it does not appear to be malicious, Rhyhorn is dumb and prone to [[RhinoRampage charging]] and Rhydon is smarter, but still destructive.
** [[OurDragonsAreDifferent Hydreigon.]] It's extremely destructive and will attack anything.
** [[EverythingsBetterWithMonkeys Mankey and Primeape.]] They are pretty much constantly in an UnstoppableRage and will stop at nothing to beat up whatever angered them.
** {{H|ellhound}}oundoom. The pain caused by the burn from its pungent flame never stops hurting.
** [[CreepyCrows Murkrow]] is a thief and is considered a [[MagpiesAsPortents bad omen]]. Its evolution is pretty much a slothful, merciless, grudge-holding mafia-don.
** Persian. It fits CatsAreMean quite well and one of them appears in the anime as a RightHandCat.
** [[OurDragonsAreDifferent Gyarados.]] Huge, vicious, and very ill tempered, it has destroyed entire cities.
** Quilava and Typhlosion. If Typhlosion's rage peaks, everything it touches bursts into flames
** [[WolverineClaws Sneasel]] is said to be extremely vicious. It drives Pidgey from their nests to eat their eggs. Its evolution, Wea''vile'', is even more devious.
** The Larvitar line. Larvitar eats an ''entire mountain'' to grow and Pupitar's thrashing can topple a mountain. [[UpToEleven Tyranitar, too]], according to various close-up shots. It's a very dangerous and aggressive TyrannosaurusRex that can destroy entire landscapes.
** While [[NeverSmileAtACrocodile Totodile]] does not appear to be malevolent, it does not realize the strength of its bite, which is bad because it has a tendency to bite or nip anything. Its first evolution, Croconaw, will not let go when it clamps down and its final evolution, Feraligatr, is surprisingly fast and savagely tears its victim up.
** Cofagrigus is said to turn people into mummies.
** Genesect. A prehistoric Pokemon. In its time, it was feared as the strongest of hunters. Apparently, Team Plasma makes it even stronger.
** Zekrom, the legendary thunder dragon. Although it can be used for good or for evil (like most other species), it can be destructive and chaotic in the wrong hands[[note]]N/Dread, anyone?[[/note]].
** [[PiranhaProblem Red Basculin.]]
** Carvanha is a vicious {{Piranha|Problem}} that evolves into a still vicious, sly shark that can swim over 75 miles per hour and thoroughly tear apart a supertanker.
** [[VideoGame/PokemonMysteryDungeon Primal Dialga]]. And Dialga, Palkia, and (especially) Giratina in general.
** Gigalith is capable of blowing away a mountain.
** [[FrogsAndToads Seismitoad]] shoots a paralyzing liquid from its head bumps. It can also smash boulders with one punch.
** The Axew line. Haxorus is kind but can be relentless when defending territory.
** In the anime, Mewtwo's eyes occasionally glow red when it uses its PsychicPowers.
** One villain from ''[[VideoGame/PokemonRanger Pokemon Ranger: Guardian Signs]]'', is actually named [[ExactlyWhatItSaysOnTheTin Red Eyes.]]
** This trope is not universal, though. Exceptions include Flannery, Chili, Pike Queen Lucy, and Hall Matron Argenta.
* The turrets in ''VideoGame/{{Portal}}'' and ''VideoGame/{{Portal 2}}'' each have a singular red eye that emits a targeting laser.
* [[spoiler:Alex Mercer]] in the final boss fight in ''VideoGame/{{Prototype 2}}''.
* In ''VideoGame/ResidentEvil4'', village leader Bitores Mendez has extremely bloodshot eyes that appear red. One of his eyes is a prosthetic, in fact. A straighter example is the cutscene where a Ganado's eyes glow red before the Plaga bursts out of its head.
** The Majini in ''ResidentEvil5''.
* In ''VideoGame/{{Robopon}}'', in the second game it's revealed that Dr. Zero's visible eye is red.
* Pretty much is a warning in "ShadowOfTheColossus." The giants' eyes are blue when they're just moving along, but if you see them turn red, it means you either attacked them or they're about to attack you--so watch out!
* The various human forms of Lucifer (Louis in his male incarnations) in the ''ShinMegamiTensei'' series should partially qualify. One of his eyes are red. And it really is just a warning, given Lucifer's status as more "chaos" than "evil", but it's a distinctive trait worth note.
** Once you've earned the True Demon ending in Nocturne, your character's eyes turn red.
* Possessed Cybil in ''SilentHill''.
* The epynomous endboss of ''VideoGame/{{Skullgirls}}'' has these, in addition to markings on her irises that make her pupils appear like the eye sockets of skulls. Aside from her, the trope is played around with with the rest of the cast: Double's EldritchAbomination form has red eyes befitting of her serving the Skullgirl, while Filia has red eyes, yet is mild-mannered. Painwheel has glowing red eyes as well, but that's largely an effect of her synthetic Skullgirl blood; she's less a villain and more a victim of mind control. In addition, Valentine has red eyes and [[WingdingEyes cross-shaped pupils]]. Then there's Peacock, whose mechanical eyes are also red, and she's [[TroublingUnchildlikeBehavior very]] [[AxCrazy much]] [[CuteAndPsycho eager]] to PaintTheTownRed.
** As of an update to ''[[UpdatedRerelease Skullgirls Encore]]'', this also applies to the skulls summoned by said aforementioned endboss when she's wearing her [[OfficialFanSubmittedContent backer-submitted]] PaletteSwap. It's worth noting that she only changes to this palette when she's [[PowerUpFullColorChange at her most powerful]], specifically when encountered on [[HarderthanHard Nightmare difficulty]] of Arcade mode or [[spoiler: as Marie 300% in Squigly's joke story mode]]
* ''Franchise/SlyCooper'': Dimitri, as seen here: [[http://i1106.photobucket.com/albums/h362/chocolatesugarviolets/272214_114363915327156_100002606448607_109086_7110130_o.jpg]].
* The Killer Bills in ''[[VideoGame/{{Something}} Something Else]]. They are faster than the usual Banzai Bill, but there are red coins that reveal their next locations.
* [[EvilTwin Metal Sonic]], the most famous Red Eyes in the Franchise/SonicTheHedgehog series.
** ''VideoGame/Sonic3AndKnuckles'''s last Act 1 miniboss is called Red Eye. In line with the trope, it is [[ThatOneBoss the most elaborate and difficult miniboss in the game]].
* In the ''SoulSeries'', most notably the first installment, ''Soul Edge'', Hwang in his [[http://www.youtube.com/watch?v=TDY2UWRg180 "no-input " ending]] returns home, but with devilish red eyes due to prolonged exposure to Soul Edge itself, not forgetting to mention his possessed facial expression that accompanies them well...
* In ''SplinterCell Conviction'', [[spoiler: the new batch of Splinter Cells]] have red optics for their sonar goggles.
* In ''VideoGame/StarFoxAdventures'', the four dinosaurs that pace along each side of the Walled City's central structure and attack you if you draw near, and the one ''huge'' dinosaur underground that serves as the boss for that part of the mission, are known collectively as "[=RedEye=]".
* [[spoiler:Faize]]'s eyes in ''StarOceanTheLastHope'' start glowing red to foreshadow his upcoming RoaringRampageOfRevenge...which doesn't end well as he unfortunately does it in a barely-armed shuttlecraft and promptly gets [[spoiler:captured and possessed by the enemy]].
* Bowser, the main villain from most of the ''Franchise/SuperMarioBros'' games, has had sinister red eyes since ''Super Mario Bros. 3''.
** The [[VideoGame/PaperMario Shadow Queen]] in Peach's body occasionally had glowing red eyes.
** [[VideoGame/SuperPaperMario Count Bleck]] also has red eyes. [[spoiler:They turn blue after his HeelFaceTurn.]]
* This is parodied in ''VideoGame/TalesOfMonkeyIsland'' from Chapters 1-4 when pirates are so infected by the [[HatePlague Pox of [=LeChuck=]]], they go into Poxed rages and even [[CutHisHeartOutWithASpoon shout out silly death threats]].
* Colette Brunel from ''VideoGame/TalesOfSymphonia'' gains red eyes when [[spoiler: she loses her soul as part of the World Regeneration. She's not so nice when she doesn't have a soul.]]
** Kratos Aurion of the same game has them all the time. It could be because he's a {{Badass}}, it could be because [[spoiler:he's TheMole to start with]], or it might just be a case of CurtainsMatchTheWindow, since his hair is the exact same shade.
** Emil Castagnier's eyes go from Green to Red when he activates his SuperpoweredEvilSide, Ratatosk Mode, in the sequel. However, this is a subversion, as Ratatosk Mode Emil is more of an AntiHero than anything. [[spoiler:Until he remembers that he wants to kill all humanity.]]
** Jade Curtiss in ''VideoGame/TalesOfTheAbyss''. His eyes are clearly brown in the anime sequences, but he has his ScaryShinyGlasses to make up for it.
*** If you follow a ([[GuideDangIt hard to find and easy to miss]]) sidequest, you learn that his eyes aren't naturally red - they turned red as a side-effect of using [[MagicPoweredPseudoscience magical phlebotinum]] on himself to strongly boost the power of his spells, since his eyes were where his ability to use magic was concentrated. The ScaryShinyGlasses act as a [[PowerLimiter limiting mechanism]], preventing all the energy in his eyes from destroying himself and whatever happens to be around him. Red Eyes, Take Warning, indeed.
** Another example is Duke from ''VideoGame/TalesOfVesperia''. He really isn't evil, per se, but he is [[spoiler: the BigBad [[FinalBoss of the game]]]]. He is, however, [[JerkAss a completely unhelpful and self-righteous jackass]].
*** [[spoiler: however, he actually is a WellIntentionedExtremist]].
** In ''VideoGame/TalesOfGraces'', it was more of a "Red ''eye'' take warning". (Note the singular) You'll notice that Richard has one red eye - [[spoiler: Which is a sign that he's possessed by Lambda.]] This occasionally glows, but doesn't become pronounced until much later in the game when it's rather obvious that [[spoiler: Richard is evil]]. However, during the events of Lineage, [[spoiler: Asbel becomes "Possessed" by Lambda, but instead his other eye is purple - signifying that Lambda's become more of a symbiote than a possessor like he was to Richard.]]
* [=ÜberCharged=] members of the [=BLU=] team in ''VideoGame/TeamFortress2'' will have glowing red eyes and be completely invulnerable to enemy fire for a brief period.
* ''VideoGame/{{Tekken}} 6'', Scenario Campaign: [[spoiler: Alisa]]'s eyes turn red when [[spoiler: Jin disengages her Safe Mode]]. Main result: [[spoiler: She's no longer able to disobey any command Jin wishes her to follow. Like kill Lars.]]
** Devil Jin, the form that Jin transforms into whenever he is fully corrupted by the Devil gene, has glowing red eyes and is not a very nice guy.
** Jin's father, Kazuya, has a glowing red left eye while his right eye is normal. His role varies from anti-hero to outright villain to anywhere inbetween at different points in the series.
* Most {{youkai}} in ''VideoGame/{{Touhou}}'' have red eyes, ranging from the [[CastingAShadow Darkness youkai]] [[WarmupBoss Rumia]], who's more likely to [[TheDitz blind herself with her own powers]] and [[WatchOutForThatTree fly straight into a tree]] rather than actually harm anyone, to [[SuperpowerLottery hugely overpowered]] [[TheTrickster oddball]] Yukari Yakumo, who is, while not actively evil, very bored and somewhat...''playful'' with people (when she's not [[BrilliantButLazy sleeping]], that is). Also, other creatures, such as vampires like the Scarlet Sisters, sport them. Reisen Udongein Inaba's red eyes can even cause lunacy.
* All vampires in ''VideoGame/VampiresDawn'' gain red eyes upon transformation. The red part increases in size if they are possessed by Shadow Ghosts.
* For the [[OurOrcsAreDifferent orcs]] in ''VideoGame/{{Warcraft}}'', it's one of their defining traits. Drinking the blood of Mannoroth gave them red eyes that glow fiery red when they descend into [[UnstoppableRage demonic bloodlust]]. Grom Hellscream in particular had them for most of his life. [[spoiler:When he gives his life to defeat Mannoroth (freeing himself and the rest of the orcs from the Burning Legion), his eyes become clear again.]]
* In ''VideoGame/{{Wadanohara}}'', there's an [[spoiler: adorable fish with big red eyes. His name is Sal. While he seems innocent enough, he ends up being the main villain of the game who was behind everything.]]
* In ''VideoGame/TheWorldEndsWithYou'', red eyes are an indication that the person is under the influence of {{Instrumentality}}. Only the Reapers actually attack, but still, that it's happening to ordinary people is a sign that something's definitely going wrong with Shibuya...
* In [[CaveStory Cave Story]], Ravils [[spoiler:(Rabid Mimiga)]] have red eyes. King is a subversion.
** [[spoiler:One of Ballos' eyes is red too, implying the red gem on the demon crown was his.]]
[[/folder]]

[[folder:Visual Novels]]
* The dragonslayer's armor in ''VisualNovel/DraKoi'' has glowing red eyes, suitable for its role as the sort-of antagonist.
* [[http://i3.photobucket.com/albums/y67/AthenAltena/Gate_of_Babylon.jpg Gilgamesh]] from ''VisualNovel/FateStayNight'' is blond with red eyes, but considering that Gilgamesh is supposed to be from Mesopotamia, it speaks more of a PhenotypeStereotype and this trope than anything else. Also, in the "Heaven's Feel" route of the game, [[spoiler:Sakura]]'s SuperpoweredEvilSide has red eyes.
** Not to mention Ilya, who uses Mystic Eyes to immobilize and kidnap the hero (ultimately, though, she's not evil).
** Caster's use of MindControlEyes is an interesting variant -- the whites of the victim's eyes turn red.
** Lancer has red eyes too, but he isn't evil in most of the storylines, although he initially appears as such.
*** Likewise, his master, Bazett Fraga [=McRemitz=] from ''[=Fate/Hollow=] Ataraxia'', has naturally red eyes, and she's one of the good guys.
** The primary theme regarding this appears to be that Servants who possess red eyes typically have varying levels of godhood. For example, Gilgamesh is 2/3 god and Lancer's true identity is a demigod as well. This also appears to apply to Berserker, who is heterochromatic, with one of his eyes being red. However, that may be the result of the Mad-Enhancement that is part and parcel to the berserker class. It is also worth mentioning that Berserker's true identity is also part-god.
** In general, vampires in the {{Nasuverse}} tend to have red eyes. People who are turned, like [[spoiler:[[MeltyBlood Sion]]]] and [[spoiler:[[{{Tsukihime}} Satsuki]]]], had their eyes turn red.
* Inverted in ''VisualNovel/{{Suika}}''. Shinigami have red eyes, but are exclusively the kindest and gentlest people who have died.
* In ''VisualNovel/UminekoNoNakuKoroNi'', the Stakes of Purgatory always wear these eyes. Considering that they are [[BigBad Beatrice's]] ''[[QuirkyMinibossSquad furniture]]'', one can guess what [[KillEmAll happens]] when they're around...
[[/folder]]

[[folder:Web Animation]]
* This trope gets a LampshadeHanging in ''WebAnimation/DeathBattle'' when discussing the Robot Masters during the analysis section of [[Franchise/MegaMan Wily]] vs [[Franchise/SonicTheHedgehog Eggman]].
--> '''Boomstick''': [[VideoGame/{{Mega Man 2}} Metal Man]] was specifically made for killing things. You could tell, 'cause he's got evil red eyes.
* Maxwell Edison, in an almost disturbingly well-done Flash video of The Beatles' "Maxwell's Silver Hammer", is depicted with red eyes.
* Yang Xiao Long of ''{{WebAnimation/RWBY}}'' typically has light purple eyes, but in battle, her eyes turn red when she's in her [[SuperMode Super Mode]]. Fittingly, she's also a fire user, meaning she can bring explosions when the trope comes into effect.
[[/folder]]

[[folder:Webcomics]]
* In ''Webcomic/{{Adventurers}}'', Khrima has solid red eyes. It's an impressive feat of comic-villainy that this makes him look more silly than intimidating.
* {{Archipelago}}: when someone makes [[DealWithTheDevil a deal with the Great Raven,]] their left eye is turned black with a red pupil.
* In ''Webcomic/AverageJoe'', Fatale's eyes go from white, to glowing red behind her mask when angered. [[http://ajcomic.com/?p=152 This]] [[http://ajcomic.com/?p=470 happens]] [[http://ajcomic.com/?p=665 a lot]].
* ''Webcomic/BobAndGeorge'': Helmeted Author has red eyes. This is one of the two things that make him different from [[AuthorAvatar the real Author]] - [[ExactlyWhatItSaysOnTheTin the other one is the obvious]].
* Webcomic/TheBongcheonDongGhost has red eyes, but by the time you see them, it's already very obvious...and too late.
* Early on in ''Webcomic/ChasingTheSunset'', whenever Leaf's eyes go red, it means he's about to unleash the Furies. Not sure if it persists later.
* In ''Webcomic/ComicShorts'', Leko the Robot's normally green eyes turn red when he gets very angry.
* Combined with HellishPupils in ''Webcomic/CommanderKitty'', when [[BigBad Zenith]] [[http://www.commanderkitty.com/2010/07/25/whose-side-are-you-on/ ends up running into Nin Wah again]]. [[spoiler: Inverted after she breaks down and is turned back on sans personality, [[http://www.commanderkitty.com/2012/10/27/not-making-it-easy/ where her red pupils instead seem to signify her being at her most docile and obedient]].]]
* Played for laughs in ''Webcomic/CtrlAltDel'', usually, one example being when Buckley got ''VideoGame/StreetFighterIV'' and grew increasingly frustrated over [[TheComputerIsACheatingBastard the computer AI being cheap]].
-->'''Buckley:''' God ''damn it, c.viper''! I swear I am going to [[CutHisHeartOutWithASpoon face-fuck you with a dump truck]]!
* ''Webcomic/DanAndMabsFurryAdventures'': Aaryanna, Aniz, Dark Pegasus, Kria, and Regina all have red eyes, and are all pretty evil to varying degrees ({{Villainy Discretion Shot}}s notwithstanding).
* The "tainted" or Ver'drowendar from ''Webcomic/{{Drowtales}}'' have red irises; they "have been seeded by a demonic entity". All drow naturally have red pupils, but this is the result of [[http://en.wikipedia.org/wiki/Tapetum_lucidum eyeshine]] and is an evolutionary adaptation to living underground, but results in tainted characters having red on red eyes.
* In ''Webcomic/ElGoonishShive'', the first time Grace is seen to shapeshift [[http://www.egscomics.com/?date=2002-03-10 her eyes go red during the transformation]]. This was dropped during all subsequent transformations.
* In ''Webcomic/{{Endstone}}'', rocking the [[ArtifactOfDoom Banestone]] [[http://endstone.net/2011/06/23/6-04/ gives Jon red eyes.]]
* Parson from ''Webcomic/{{Erfworld}}'' gains red eyes after completing his sword, in a panel that makes him look genuinely frightening for the first time in the series.
* ''Webcomic/TheFoxSister'': The [[FantasticFoxes Kumiho]] loves this one.
* In ''{{Webcomic/Freefall}}'', [[http://freefall.purrsia.com/ff1400/fc01335.htm a vengeance-minded robot has glowing red eyes for a moment.]]
* ''Webcomic/GunnerkriggCourt'':
** The yellow salamander/lizard-thing. It may not have been evil, per se, but it was certainly dangerous. [[spoiler: The lizard was a house fire that killed a small child and his family.]]
** Zimmy plays an odd variation of the trope. Normally she seems to have BlackEyesOfEvil, but when she is temporarily purified from the etheric miasma that pollutes her spirit by natural rain, it turns out that [[http://www.gunnerkrigg.com/?p=196 her eyes are bright crimson underneath]]. In this condition she is a lot more coherent and amiable than her usual self, but acts as a reminder that she's not exactly normal, either way.
** Hetty has red eyes and is as evil as they imply, as seen from her suggestion that Reynardine kill Antimony and her IrrationalHatred toward Adam.
* ''Webcomic/GaiaOnline'':
** Johnny K. Gambino.
** And, ironically, his opposite number, Vladimir Von Helson, via heterochromias (one gray as is standard for [[OurVampiresAreDifferent Gaian vampires]], one red apparently just for the sake of this trope).
* ''Webcomic/GirlGenius'': while subtle, it is seen well [[http://www.girlgeniusonline.com/comic.php?date=20120102 in this strip]] that Mama Gkika has red eyes. Possibly other Jägers, too.
* Marceline from ''Webcomic/GodMode'' is described as a "[[http://godmodeonline.com/d/20051205.html sado-masochistic chain-smoking woman]]". Which is more or less true.
* All the vampires in ''Webcomic/HannaIsNotABoysName'' have red or reddish eyes, although some are more evil than others and the least evil of the four we've seen so far isn't drawn with visible irises at all.
* Panim, the MisanthropeSupreme from ''Webcomic/HelloWorld''.
* In ''Webcomic/ImpureBlood'', [[http://www.impurebloodwebcomic.com/Pages/Issue4PAGES/ib082.html when annoyed]]. Note that her eyes can also glow blue for other magical purposes.
* ''Webcomic/{{Kagerou}}'': when (the aptly-named) Red takes over Kano's body, his eyes turn red. And Red is a psychopathic rapist and murderer.
* Valentino, the BigBad of ''Webcomic/{{Marilith}}'', has red eyes. The effect is highlighted by the rest of the strip being mostly in black and white.
* Otherworlders in ''Webcomic/{{Miamaska}}'' have red eyes and purple sclera. Citizens see this as a threat to their town and [[http://miamaska.tidalcomics.com/index.php?strip_id=49 take action accordingly]].
* ''Webcomic/TheOrderOfTheStick'':
** Sabine's eyes glow red in her true form. There is an early warning of her true nature in [[http://www.giantitp.com/comics/oots0053.html this strip]], which is before she's revealed to be a fiend. Later, the glowing-red eyes are a [[http://www.giantitp.com/comics/oots0356.html hint for the reader]] that she's shapechanged.
** Xykon has [[GlowingEyelightsOfUndeath glowing red eyes]] too.
** Also, [[http://www.giantitp.com/comics/oots0079.html Loki]], god of Flames and Chaos.
** [[spoiler: Malack's]] eyes change to red from their usual [[spoiler: [[EvilAlbino pink]]]] when using his vampiric abilities.
* ''Webcomic/PennyArcade'':
** Tycho gets these whenever he gets particularly angry or is acting particularly evil, apparently because his body harbors a dark spectre from the world of dreams.
** ''Webcomic/PennyArcade'' sub-comic ''Automata''. There's something in that time signature and it changes the eyes from the standard blue to...[[http://www.penny-arcade.com/comic/2009/8/3/ help.]]
* ''Webcomic/RescuingDara'' [[AvertedTrope averts]] this trope, with the hero Chivai and both the heroic and villainous Lucarios all having red eyes.
* In ''Webcomic/{{Roza}}'', [[http://www.junglestudio.com/roza/?date=2007-05-23 the monstrous guard]].
* ''Webcomic/SluggyFreelance'': In one story, Bun-bun the evil mini-lop rabbit is stuck with the annoying animated shadow of the groundhog who's the AnthropomorphicPersonification of Groundhog's Day. Unable to attack the insubstantial creature, he's forced to suffer all its antics. But finally it manages to do something that angers Bun-bun so much that he finally snaps. He gets ''so'' angry his eyes turn red, and subsequently he emits a red aura. Insofar as there is an explanation to this, it could be that [[spoiler: by that time Bun-bun was already a mildly supernatural being due to being saddled with being the Easter Bunny as well as the official "groundhog".]]
--> '''Shadow''': What do you want to do?
--> '''Kiki the ferret''': I have a pretend karaoke machine made from a toilet-paper roll!
--> '''Shadow''': You like karaoke too?
--> '''Kiki''': I LOVE karaoke!
--> '''Shadow''': A one and a two and a
--> '''Bun-bun''': '''''That's IT! Everybody dies!'''''
* Dr. Schtein of ''Webcomic/StringTheory'' has prosthetic eyes that glow a sinister red, having lost his original eyes in a lab explosion. Thus far, they seem to be foreshadowing his eventual rise to supervillany.They even glow in the dark, much to the horror of his prison roommate.
* Darko, the mercenary from ''Webcomic/TheStupiders'' has glowing red eyes: ''[[http://www.stupiders.com/comic.php]]''.
* ''Webcomic/{{Terra}}'' has Sovereign Northazul Kalar, EvilOverlord of an empire trying to conquer the galaxy, and his son Solus Kalar, head of a NebulousCriminalConspiracy that started out as a private army for Northazul.
* Subverted in ''Webcomic/TwoGuysAndGuy'': Wayne thinks [[http://www.twogag.com/archives/2204 Guy's eyes glow red in the dark]] ''because'' she's evil. [[spoiler: The optometrist is pretty upset Wayne didn't mention it sooner, implying it's not only unnatural but also dangerous.]]
* ''Webcomic/{{Underling}}'': [[http://underlingcomic.com/page-seventy-five/ Demons.]] This is awkward for Lazarus when he gets them, and a tail, and horns.
* ''Webcomic/{{Waterworks}}'': Flush gains a set of red eyes just before he uses his deadly SpinAttack. [[http://mspfanventures.com/?s=43&p=238 "oh hey flush. you're sporting the evil red eye look rather nicely"]]
[[/folder]]

[[folder:Web Video]]
* In ''WebVideo/MicrosoftSamReadsFunnyWindowsErrors'', when ever Sam is seen with red eyes, it's not a good sign.
* PlayedForLaughs when TheNostalgiaChick reviewed the ''MyLittlePony'' (Gen 1) movie: a certain pony had red eyes for no apparent reason. Every time she came on screen ominous music would start playing and the Chick would freak out.
-->"''And what's with your demon eyes?!''"
[[/folder]]

[[folder:Western Animation]]
* ''WesternAnimation/AtomicBetty''
** In an episode when RichBitch Penelope is cloned, the clone has red eyes. It is probably less evil than the original.
** [[CatsAreMean Koreena]], Betty's old rival turned villain, also has red eyes.
* ''WesternAnimation/TheBatman''
** SelfDemonstrating/TheJoker has nearly completely red eyes (but yellow pupils). His ''WesternAnimation/BatmanBeyondReturnOfTheJoker'' design (also used for ''WesternAnimation/StaticShock'' and ''WesternAnimation/JusticeLeague'') also has red pupils sometimes, if you look closely. The red eyes on the latter-day Franchise/{{DCAU}} design, along with the slicked-back hair sported by the Future Joker design in ''Return of the Joker'', were inspired by the novel's descriptions of Hannibal Lecter.
** ''The Batman'' also gives red eyes to Mr. Freeze (who appropriately has IcyBlueEyes in other incarnations, but usually hides them behind [[SinisterShades red goggles]], justifying the change made in the cartoon).
* ''WesternAnimation/BatmanTheBraveAndTheBold'': The eyes of Ultra-Humanite's army of mind-controlled dinosaurs glow red in "Four Star Spectacular!"
** Inverted with the Blue Beetle, where when his eyes are red, he's friendly.
* WesternAnimation/BugsBunny cartoon ''Hyde and Hare''. When Dr. Jekyll turns into the evil Mr. Hyde his eyes turn red. After Bugs drinks the formula and turns into a giant green rabbit the same happens to him.
* ''WesternAnimation/BuzzLightyearOfStarCommand''
** The AffablyEvil Emperor Zurg.
** Also, XR had red eyes during his brief stint as villain NOS-4-A2's vampire slave.
* ''WesternAnimation/DannyPhantom''
** Several of Danny Phantom's enemies have red eyes, including his arch-rival, Vlad Plasmius (whose eyes are blue in human form and completely red and pupil-less in ghost-form), and his [[FutureMeScaresMe sociopathic alternate-future self]], Dark Danny (AKA Dan Phantom). Red-eyed DungeonMaster Clockwork, on the other hand, despite being originally portrayed as a villain, is good-hearted but on the neutral side.
** Danny's own red eyes when under the control of Freakshow in "Control Freaks".
* PlayedWith on ''WesternAnimation/{{Gargoyles}};'' [[BigBad Demona]], the [[KillAllHumans evil]] gargoyle, has eyes that glow red when she's angry while our heroes' glow white. However, it was later established that it was a sex-linked trait; [[AffirmativeActionGirl Angela]], a hero, also has red-glowing eyes.
* Odd variant: while Serpentor from ''Franchise/GIJoe: A Real American Hero'' was always evil, his eyes briefly turned red when he held the battleax of Vlad the Impaler, one of the many historical tyrants whose DNA he shared. This was presumably a hint that Vlad had really been a vampire in the show's universe and contact with one of his artifacts had evoked that trait in Serpentor.
* Skeletor, nemesis of He-Man from ''WesternAnimation/HeManAndTheMastersOfTheUniverse2002''. His eye (sockets) function as a literal warning, as little red lights start growing in them when he gets angry or excited in evil ways.
* The Grinch in ''WesternAnimation/HowTheGrinchStoleChristmas'' has red pupils on yellow for most of the film. His eyes turn blue-on-white during his HeelFaceTurn, then switch back (by mistake?) for a few shots, then stay blue.
* In ''WesternAnimation/JackieChanAdventures'', the Shadowkhan, among others, have red eyes.
* ''WesternAnimation/JonnyQuest'' TOS episodes
** "Monster in the Monastery". The fake yeti (who are malicious enemy agents) have red eyes.
** "The Robot Spy". The titular opponent - which was sent by the DiabolicalMastermind Doctor Zin - has one large red eye.
* The Biskit twins in ''WesternAnimation/LittlestPetShop2012'' have reddish eyes, though they're not so much evil as they are sheltered and distant from those around them.
* Dick Knubbler's robotic eyes turn red when he gets pissed off in ''WesternAnimation/{{Metalocalypse}}''. Not so much "evil" as "{{Jerkass}}", but when one works for five ChaoticNeutral musicians that cause destruction wherever they go (by accident, sometimes, even!), it's hard to call oneself "good".
* In ''WesternAnimation/MyLittlePonyFriendshipIsMagic'', the [[ArtifactOfDoom Alicorn Amulet]] makes the wearer's eyes go red. Trixie, who showcases the effect, becomes drunk with power and starts acting outright like a tyrant, as opposed to her moderate {{Jerkass}} tendencies.
** In "Power Ponies", Fluttershy's eyes turn red when a firefly was flicked out of the crosshairs of the weapon as part of her HulkingOut.
** Fluttershy gets red eyes again in "Bats", when she's turned into a [[OurVampiresAreDifferent vampire]].
* ''WesternAnimation/TheNewAdventuresOfSuperman'': "The Japanese Sandman". The titular monster (who commits evil acts in return for a black pearl) has red eyes.
* ''{{Ninjago}}: Masters of Spinjitsu''. All the skeletons, Lord Garmadon and the Hypnobrai tribe have glowing red eyes.
* In ''WesternAnimation/ThePenguinsOfMadagascar'' special, "Dr. Blowhole's Revenge", Skipper activates a King Julien robot decoy.
-->'''Skipper:''' Glowing red eyes. That's almost never good.\\
(''the robot explodes'')
** In "The Hoboken Surprise" all the animals are replaced with robots with red eyes.
* ''WesternAnimation/ThePowerpuffGirls'' (and its [[Anime/DemashitaPowerpuffGirlsZ anime]] and [[Manga/PowerpuffGirlsDoujinshi comic]] counterpart) gives us Brick of the [[ThePsychoRangers Rowdyruff Boys]]. True to this trope, Brick, while not necessarily evil, does love to [[ChaoticEvil cause destruction and hurt others]] (well, in the show and anime at least, the comic may avert this).
* ''WesternAnimation/ScoobyDooWhereAreYou'' episode "A Gaggle of Galloping Ghosts". The [[UsefulNotes/{{Romani}} Gypsy]] FortuneTeller, who turns out to be the episode's {{villain|s}} in disguise.
* Dr. Julian Robotnik from ''WesternAnimation/SonicSatAM'' has a pair of red cybernetic optics that shine like hellish spotlights in the dark.
* Squidward, Plankton, and Man Ray from ''WesternAnimation/SpongebobSquarepants''. Averted with Gary. Ironically, the former two are now the most sympathetic characters on the entire show.
* ''WesternAnimation/AaahhRealMonsters'' before he transforms into his OneWingedAngel form, Ickis' eyes start turning red, complete with a sound effect that sounds like they're filling up with blood.
** To a lesser extent [[SadistTeacher The Gromble]], whenever he's '''''really''''' ticked off his eyes start turning red much in the same manner as Ickis' eyes before he looms.
* The Son in the Mortis episodes of ''WesternAnimation/StarWarsTheCloneWars'' Season 3, combined with black sclera.
* ''WesternAnimation/{{Superfriends}}''
** 1973/74 episode "Menace of the White Dwarf". The BigBad, Raven (who acts more like a ComicBook supervillain than any other opponent the Superfriends faced during this season), has red eyes.
** The evil Superman from the 1979 episode "[[MirrorUniverse Universe of Evil]]" has red eyes as well, and for bonus points, they're ringed in black, [[http://images2.wikia.nocookie.net/__cb20090623171754/superfriends/images/6/6a/EvilSuperman.png with freakin' huge demonic points]]. Evil!Batman and Evil!Robin also have red eyes in place of their good counterparts' [[MonochromaticEyes plain white eyes]].
* ''WesternAnimation/TeenTitans''
** Trigon, [[{{Satan}} very bad dude]] indeed.
** Brother Blood, BigBad of the third season, has eyes that glow red when he uses his PsychicPowers; in the fifth season, the mechanical eyes on the skull-"face" on the Brain's life-support pod also glow red when the Brain is interfacing with his computers or is just angry.
* Nearly all the Decepticons of the original ''Franchise/{{Transformers}}''. Later versions had a bit more optical variety.
** ''WesternAnimation/TransformersAnimated'' has all red-eyed (or in the case of Soundwave, red-''[[CoolShades sunglassed]]'') Decepticons like the original cartoon, with the exception of the technically-not-a-Decepticon Swindle, who has purple eyes. However, Sari Sumdac, a ''human child'', also appears to have red eyes. [[spoiler:They turned [[http://static.tvtropes.org/pmwiki/pub/images/vlcsnap-488331.jpg blue]] after she [[SuperMode "upgraded" herself.]]]] Also, in ''Animated'', Wreck-Gar's eyes turn red when he briefly became a Decepticon due to his FunnySchizophrenia and being incredibly suggestible. An interesting example occurs in Wasp. Originally, he had blue eyes, but after his stay in prison (and subsequent madness and desire to turn Bumblebee into iron filings), they become purple. And what color do you get when you mix red and blue?
*** [[spoiler:The Autobots']] eyes also turned red when they were brainwashed by [[spoiler:Soundwave]] into being evil.
** Silverbolt from ''WesternAnimation/BeastWars''' optics are normally gold, but when Blackarachnia was killed and he uttered Tarantula's name in a vengeful manner, [[BewareTheNiceOnes they]] [[RoaringRampageOfRevenge turned]] [[NightmareFuel red]].
** [[DemonicPossession False Convoy]] in ''TransformersReturnOfConvoy'' is distinguished from Optimus Prime by having red eyes instead of blue.
** ''[[TransformersShatteredGlass Shattered Glass]]'', of course, reverses this, with the Decepticons mostly having blue optics and the Autobots mostly having red ones. Though there are a fair number of green, yellow, and other oddball optic colors on both sides, and Heatwave strangely has red optics despite being a nice guy, even by his fellow Decepticons' standards. [[spoiler:Turns out, it's because he's not actually from the SG universe at all.]]
* The Duke from ''WesternAnimation/{{Gawayn}}''
* Trina Riffin from ''WesternAnimation/{{Grojband}}'' whenever she's writing in her diary in Anger or Fear mode.
[[/folder]]

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