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A character, generally the main character and a child or minor in age, is shown to have missing, dead or otherwise absent parents. Because there is still the need for an adult figure around, the character's grandparents fill in the void. Generally, there are no aunts or uncles in the picture. If there are, that's {{Nephewism}}.

The child may feature as a HeartwarmingOrphan. When using this trope would interfere with the plot, you often get a WorldOfNoGrandparents.

[[TruthInTelevision This happens in real life as well.]] FamilyRelationshipSwitcheroo commonly involves a cover-up of this situation, when the child is raised by grandparents but is made to believe them to be their real parents, in order to avoid admitting that their "sibling"-but-really-parent conceived them outside wedlock.


[[folder:Anime & Manga]]
* Pinako Rockbell of ''Manga/FullmetalAlchemist'' raised her granddaughter, Winry, after the murder of the young girl's parents. This was immediately after the death of the mother of two neighborhood boys (prior in the [[Anime/FullmetalAlchemist 2003 adaptation]]), Ed and Al Elric, and she ended up with all three. She seems to have done a good job, as all three are prodigies in their respective scientific fields.
* Joseph Joestar in ''Manga/JoJosBizarreAdventure'' was raised by his grandmother Erina, since his father George II died in the [[UsefulNotes/WW1 Great War]] and his mother [[spoiler: Lisa Lisa]] had to go on the lam for killing a British military officer [[spoiler: who was actually a zombie minion of Dio Brando in disguise, and the real killer of George II]].
* Yoh's grandparents, Kinu and Yohmei, in ''Manga/ShamanKing''
* Yugi's grandfather in ''Anime/YuGiOh''. He does have a mother, but she got {{Brother Chuck}}ed quite quickly. Rebecca Hawkins, as well.
* In ''Manga/OnePiece'', Luffy and Ace were watched over by their grandfather, [[spoiler:Vice-Admiral Garp]]. Somewhat subverted in that [[spoiler: Garp wasn't Ace's grandpa by blood, but actually adopted him upon the request of Ace's biological father. Garp still considered him his grandson anyway, even if adopted.]]
* ''Manga/{{Naruto}}'':
** Konohamaru. But curiously, there are lots of orphans, but grandparents appear much less often than parents.
** Sasori ended up being raised by his grandmother Chiyo after his parents were killed in battle [[spoiler: by Kakashi's father Sakumo]] when he was 6.
* Arika Yumemiya from ''Anime/MaiOtome'', and Grandma's sayings are quoted throughout the show.
* Rei/Mars from ''Franchise/SailorMoon'' is raised by her maternal grandfather after her mom dies. In [[Manga/SailorMoon the Manga]] and [[Series/PrettyGuardianSailorMoon Live action]], her father Takashi is still around but she refuses to have anything to do with him [[spoiler: because of his cold treatment of her IllGirl mother Risa, not visiting her a single time until her death]]; he isn't mentioned in the [[Anime/SailorMoon anime]]. Her grandfather isn't mentioned in the live action (nor anyone else she may be living with) thus not using this trope.
* In ''Manga/FushigiYuugiGenbuKaiden'' [[spoiler: Firuka and Haagasu's]] ''great''-grandson is raised by Limdo to become the next emperor, because he has no heir of his own.
* Link is raised by his grandparents (including his BadassGrandpa) in the [[Manga/TheLegendOfZelda manga adaptations]] of ''VideoGame/TheLegendOfZeldaOracleGames''.
* Ushio from ''VisualNovel/{{CLANNAD}}'' lives with her grandparents until she's five years old, because [[spoiler:Tomoya sees her as a reminder of his wife Nagisa, who died giving birth to her, and can't handle the depression. Once she's five, however, they start rekindling their bond.]]
* When first introduced, Yukito Tsukishiro from ''Manga/CardcaptorSakura'', though as they're often said to be out of town, his grandparents are never seen. [[spoiler:As Yukito is the "false form" of the magical being Yue, most of his background is actually false memories, including his grandparents. ''They simply don't exist''.]]
* In the manga ''Manga/BabyAndMe,'' one of Takuya's classmates claims to live with her grandparents because her father and mother are famous and are overseas. [[spoiler:Actually, it turns out that her grandparents are really her ''parents,'' and she's embarrassed about the fact, so she lies.]]
* Renton in ''Anime/EurekaSeven'' was raised by his grandfather after his mother [[DeathByChildbirth died in childbirth]] and his father Adrock sacrificed himself during the New Era Summer of Love when Renton was a young child. His uncle appears in one episode, however.
* Miu in ''Manga/KenichiTheMightiestDisciple'' was raised by her grandfather Hayato.
* ''Manga/{{Bleach}}'':
** Yasutora "Chad" Sado. Chad's parents died when he was a little boy, so he spent a good part of his life under the watch of a Mexican CoolOldGuy named Oscar Joaquin de la Rosa, whom he referred to as "abuelo" (Spanish for "grandfather"); it's not fully known if the "Abuelo" was his real grandpa, a distant relative or a mere family friend, but Chad considered him as his gramps for all that was worth.
** Same goes to Toshiro Hitsugaya and Momo Hinamori, raised together in Rukongai by an old lady whom they both called grandmother.
* ''Webcomic/AxisPowersHetalia'':
** In the original ''Gakuen Hetalia'', Seychelles mentions that she used to live with an old man she referred to as "grandfather". Since she's a nation-tan, it's highly doubtful they're 100% relatives.
** Also, the young Italies used to live with their grandfather Ancient Rome until his "death", then were taken in either by Austria and Hungary (Chibitalia) or Spain (Chibimano).
* Kaoru Hanabishi from ''Manga/AiYoriAoshi.'' Unluckily for him, the trope comes along [[AbusiveParents abusive grandparents]].
* Since Kotetsu Kaburagi from ''Anime/TigerAndBunny'' can't properly raise his daughter Kaede due to his superhero role and Kaede's mother Tomoe died of illness years ago, Kaede lives with her paternal grandmother (and her uncle Muramasa aka Kotetsu's older brother) instead and has no idea about his SecretIdentity [[spoiler: until the second half of the series.]]
* Lunlun from ''Anime/HanaNoKoLunlun'', since [[spoiler: mom [[DeathByChildbirth died in childbirth]] and dad followed five years later.]] Also some of the people she helps, like a Spanish girl named Isabel and a Moroccan boy named Sayid.
* Takeshi Sendoh from ''Manga/HajimeNoIppo''. His mother died few after he was born (''maybe'' [[DeathByChildbirth because of childbirth]], but it's not specified), his father was a firefighter who died in the line of duty when Sendoh was around five years old. Hence why he was raised by his widowed grandmother, the owner of a small shop in Osaka's ward of Naniwa.
* [[spoiler: Mario and Masako Natsume]] from ''Anime/MawaruPenguindrum''. [[spoiler: unfortunately, they also were victims of their grandfather's abuse.]]
* Shinobu Iijyuin from ''Manga/HaikaraSanGaTooru'', since his father is a very high ranked military man stationed abroads [[spoiler: and his mother was a German noblewoman who never was accepted by Japanese society, so she had to leave baby!Shinobu with the Iijyuin clan.]]
* Mei from ''Literature/ArashiNoYoruNi'' is raised by his grandmother, as his biological mother was killed protecting him from Giro and his pack of wolves in the prologue.
* NiceGuy Panther from ''Manga/{{Eyeshield 21}}'' was raised by his grandmother whom had given him his treasured sweatband. She was also the one who provided him the money with her own savings to go to Japan. He desired to join the NFL so his grandmother would no longer have to work.
* Misaki from ''Manga/HanaNoMizoShiru'' was raised by his grandfather after his parents died in accident...for a few years, until ''he'' died, too. Then he's left in [[SexyMentor Kawabata's]] care, which doesn't really end well.
* In ''Manga/KotouraSan'', after Haruka was [[IHaveNoSon disowned]] by her parents, it was implied she was raised by her grandfather Zenzou.
* Sandra was raised by her maternal grandmother in ''Manga/ACruelGodReigns''.
* Ryou of ''Manga/GourmetGirlGraffiti'' have been living with her grandmother since her parents started working overseas six years ago.
* Takuto, the main character of ''Anime/StarDriver'' was raised by his BadassGrandpa who also taught him the art of DualWielding swordfighting and how to use his Cybody. It seems like his mother left her son with Icaro at an extremely early age, as Takuto only knows what she looks like from one single photo. The female protagonist, Wako, also seems to have been raised by her grandmother alone, although we never get to hear what actually happened with her parents.
* Tsubomi in ''Anime/HeartcatchPrettyCure'' was raised by her grandmother while her parents were constantly on business trips. This came to a screeching halt 13 years later when she had an emotional breakdown at just the right time, prompting her parents to stop their trips and make up for all of the lost time.
** This is repeated again in ''Anime/DokiDokiPrettyCure" with Aguri a.k.a the kid that turns into the Trump Card of Love, Cure Ace.
* The titular character Izetta from ''Anime/IzettaTheLastWitch'' was raised by her grandmother prior to the beginning of the series.
* In ''Anime/YuriOnIce'', Yuri "Yurio" Plisetsky is strongly implied to have been raised by his grandfather Nikolai. As said below, this seems to be pretty common in Russian society.
* In ''Manga/PrivateActress'', Shiho Kobayakawa was initially raised by her maternal grandmother. The lady died of a heart attack some time later, [[spoiler: after a huge fight with Shiho. [[NeverGotToSayGoodbye Shiho herself is still]] [[PartingWordsRegret very remorseful for this]].]]
* This is the reason why Keitaro from ''Manga/LoveHina'' calls his fist cousin Haruka "aunt". Her parents died when she was young and Grandma Hina adopted her, meaning that she is simultaneously Keitaro first cousin and his aunt.

* Creator/ChrisRock discusses this in his special ''Bigger and Blacker''. He says that "if a kid calls his grandmama 'Mommy' and his mama 'Pam', he's going to jail".

[[folder:Comic Books]]
* In one continuity, ''Comicbook/{{Legion of Super-Heroes}}''' Luornu Durgo (Triad/Triplicate Girl/Duo Damsel) was raised by her grandmother, until she died and Luornu was sent to a mental hospital, due to her three selves not being emotionally identical. The grandmother was like this, as well, though she didn't reveal it to Luornu until shortly before she died.
* The ''Franchise/{{Batman}}'' villain Dr. Jonathan Crane aka The Scarecrow was raised by his grandmother. [[AbusiveParents She was not a pleasant woman]] and it did not turn out well.
** The same goes for Humphrey Dumpler, AKA Humpty Dumpty. Befitting his nickname, he cut her apart and tried to put her back together again to "fix" her. He sowed her up with shoe strings.
** Damian Wayne was partly raised by his grandfather, Ra's al Ghul, though his mother was also present.
* [[StraightGay Billy]] of ''ComicBook/BuffyTheVampireSlayer Season 9'' who is being raised by his grandmother because his parents kicked him out when he came out to them.
* ''ComicBook/StrontiumDog'': Middenface [=McNulty=] was raised by his gran, a [[NeverMessWithGranny tough old biddy]] in the best Glaswegian tradition.
* ''ComicBook/{{Shazam}}'''s Freddy Freeman, aka Captain Marvel Jr., was raised by his grandfather from the time his parents died until Grandpa Freeman was killed by Captain Nazi.

[[folder:Fan Works]]
* In ''Fanfic/TheRacketRotterChronicles'', Harwood tells Annette that his maternal grandparents raised him, much to her surprise. [[spoiler: This is because his parents were murdered when he was a child.]]
* ''Fanfic/CodeGeassThePreparedRebellion'' has Milly Ashford, who was raised by a combination of her grandfather and an old nursemaid. She didn't meet her parents until she was five, and disliked them both almost immediately.

[[folder:Films -- Animation]]
* In ''Disney/AtlantisTheLostEmpire'', Milo Thatch was raised by his late grandfather Thaddeus Thatch (whose best friend was apparently Preston Whitmore until Thaddeus "was laughed at and died a broken man") because his biological parents were both killed in a railway accident.
* In ''WesternAnimation/TheLandBeforeTime'' (sequels, that is), Littlefoot is raised by his grandparents. Although the end of the first movie implied it pretty clearly.
* Possibly [[TheWatson Wybie]] in ''WesternAnimation/{{Coraline}}'' -- it's not spelled out, but we repeatedly hear his grandmother call him home and learn about her past with no mention of his parents.
* In ''WesternAnimation/TheBookOfLife'', a line from a young Manolo implies that after Joaquin's father died and his mother left, his grandmother raised him.
* In ''Anime/YourName'', Mitsuha and Yotsuha are raised by their maternal grandmother Hitoha after their mother's death and what it does to their father.

[[folder:Films -- Live-Action]]
* Masao in Takeshi Kitano's ''Film/KikujiroNoNatsu'' is a boy who is raised by his grandmother. The plot involves his looking for his estranged mother during the summer vacation (and meeting an oddball surrogate father figure).
* In ''Film/LettersToJuliet'', Charlie's parents died when he was young so he was raised by his grandmother, which explains why he was protective around her.
* In ''Film/TheHuntForRedOctober'' Captain Marko Ramius was raised by his paternal grandfather, a fisherman who taught him to fish.
* The five girls in ''Film/{{Mustang}}'' were raised by their grandmother.
* ''Film/MenaceIISociety'': Caine was raised by his grandparents after his father (a drug dealer) was shot to death and his mother (a crack fiend) died of an overdose. It's clear that they can't keep him from getting involved in the thug life, and Caine's grandfather eventually evicts him from their home.
* Actually ''subverted'' in ''Film/CaptainAmericaCivilWar'' as Tony Stark believes that Aunt May is a kindly old grandma but finds her to be smoking hot. Being played by Marisa Tomei helps. It makes thing awkward as calls her "Aunt Hottie" right to Peter.
* ''Film/EnterTheVoid'': Deconstructed. It is implied that after the car crash that killed their parents, Oscar and Linda are initially being taken care of by their (paternal?) grandparents, but since they're just too old to take care of kids any longer Oscar and Linda are forcibly split up and moved into different foster families.

* ''Literature/{{Heidi}}'' starts when the title character goes to live with her paternal grandfather. Her friend Peter is raised by both his mom ''and'' his blind grandma.
* Neville Longbottom from ''Literature/HarryPotter'' was raised by his ApronMatron grandmother, Augusta, because [[spoiler: the ColdBloodedTorture from Barty Crouch Jr. and the Lestranges drove his parents Frank and Alice mad.]]
** According to WordOfGod, [[spoiler:Teddy Lupin]] is raised by his grandmother after his parents die in the last book, with a good bit of help from [[spoiler:his godfather, Harry]].
* Rajput CoolOldLady in ''Literature/{{Kim}}'' by Creator/RudyardKipling took it upon herself, though due to her style it was rather taxing for everyone around as well:
--> He is wearied, and I forgot, being a grandmother. (None but a grandmother should ever oversee a child. Mothers are only fit for bearing.)
* In the ''[[Literature/AmericanGirlsCollection American Girl]]'' historical fiction series, the Victorian-era Samantha is raised by her wealthy grandmother because [[spoiler: her parents died on a boat. No, not [[UsefulNotes/RMSTitanic that one]].]]
* [[spoiler: Allanah Solo]] in the Franchise/StarWarsExpandedUniverse.
* Peter Hartling's book ''Literature/{{Oma}}'' ("Grandma") is about an CoolOldLady who takes in her 5-year-old grandson Karl aka Kalle after his parents die. They both have to deal with the loss [[spoiler: and with the grandmother's ailing health.]]
* In ''Literature/LesMiserables'', Marius Pontmercy's grandfather takes him away from his father after his mother dies by threatening to disinherit him if his father raises him.
* In ''Literature/FireAndHemlock'', Polly is raised by her grandmother from around thirteen, after both her mother and father send her away to avoid difficulty with their love interests, leaving Polly stranded and sick in the middle of a strange city. Granny flatly refuses to let Polly's mother take her back even when she offers.
* In ''Literature/DoctrineOfLabyrinths'', Corbie was raised by her grandmother, who is implied to have died at some point before she meets Felix and Mildmay. Her parents remain shrouded in mystery as she never gives any information about her mother, and all she knows about her father is that he was probably a Ygressine sailor because she looks almost exactly like the Ygressine people about town.
* ''Literature/BrownGirlInTheRing'' 's main character Ti-Jeanne is raised by her grandmother Gros-Jeanne.
* ''Literature/TheChangeover'': The male lead, Sorenson Carlisle was originally raised by foster parents, but after suffering abuse at their hands, he managed to escape to his birth mother and grandmother's dwelling place.
* In "The Sword Bearer", John is raised by his maternal grandmother after his mother dies in childbirth. His father is missing [[spoiler:until late in the book, and didn't even know he ''had'' a child.]]
* Captain Marco Ramius in ''Literature/TheHuntForRedOctober'' was raised by his grandmother since his father was off being the model Soviet hero, something that shamed Marco deeply.
* In Banana Yoshimoto's ''Kitchen'', Mikage Sakurai was raised by her grandmother. The plot starts when Mrs. Sakurai dies and Mikage moves in with a friend of her, Yuuichi.
* The main character in Creator/{{Robert Bloch}}'s "Floral Tribute" was raised by his grandmother until the authorities found out that she saw dead people and transferred him to an orphanage.
* Corie is being brought up by her maternal grandmother in ''Literature/SummersAtCastleAuburn''.
* In ''Literature/TheHouseOfNight'', due to ParentalAbandonment by both Zoey's mother and father, Grandma Redbird pretty much raised Zoey and continues to help out whenever possible.
* In ''Literature/TheSecretOfPlatform13,'' [[NiceGuy Ben]] is raised by his grandmother, Nanny Brown, who was the unwilling accomplice to the villain, [[RichBitch Mrs. Trottle]], when she kidnapped [[SpoiledBrat Raymond]]. [[spoiler:{{Subverted}} because she's not actually his grandmother; Ben is the kid Mrs. Trottle kidnapped, and passed him onto Nanny Brown when she got pregnant with Raymond]].
* In Jack Vance's ''Demon Princes'' quintet, young Kirth Gersen is raised by his grandfather Rolf after ''everyone else in their family'' is either enslaved or murdered by the titular villains. Grandpa turns him onto (and trains him for) the path of vengeance.
* ''Literature/{{Tinker}}'' and her cousin Oilcan were raised by their grandfather. Tinker spent literally her whole life under his care, as he had her made from his dead son's sperm and a donor egg.
* ''Literature/RabbleStarkey'': For the first eight years of her life, Rabble was raised by her grandmother while her mother, who was fourteen when she gave birth, grew up.

[[folder:Live-Action TV]]
* Prue, Piper, and Phoebe from ''Series/{{Charmed}}'' were raised by their grandmother after their mother's death and father's abandonment.
* Mako/Shinken Pink from ''Series/SamuraiSentaiShinkenger'' was raised by her grandmother. Both her parents are actually still alive but her mother was crippled in the climatic fight of the last generation and was unable to train her daughter in the family traditions.
* It's revealed in the first episode of ''Series/TheATeam'' that Murdock's mother died when he was five years old. His father is never mentioned. He mentions both grandparents on occasion, and it's implied that they may have raised him.
* Sookie Stackhouse and her brother Jason in ''Series/TrueBlood'' were raised by their grandmother after their parents died in a flood.
* Special Agent Seeley Booth from ''Series/{{Bones}}'' was taken from an abusive alcoholic father and raised by his grandfather.
** It's indicated Brennan was rescued from foster care by her grandfather, but there's later info that makes things fuzzy about this.
* Thalia's character Marimar in the SoapOpera [[RoleCalled of the same name]] was raised by her grandparents in a cute little shack near the sea. [[spoiler: Then, they died in a fire. ''Literally''.]]
** Actually a pretty standard upbringing in {{Soap Opera}}s, if the hero/heroine is orphaned.
* Warrick Brown on ''Series/{{CSI}}''.
* Gentarou Kisaragi, a.k.a. ''Series/KamenRiderFourze'' lives with his grandfather in the latter's motor shop [[spoiler:after losing his parents at an early age.]]
* A plot point in one episode of ''Series/StargateSG1'' is that Daniel's parents died--in front of him--when he was eight years old and his famous anthropologist grandfather didn't take him in. Adult Daniel is still a little bitter about that.
* ''Series/OnceUponATime'': Red Riding Hood was raised by her grandmother [[spoiler: after Red's fellow-[[TheBigBadWolf wolf]] mother was killed by hunters. What happened to her father is never mentioned, but given what Red [[IAmAHumanitarian accidentally does to her love interest]], [[FridgeHorror that's probably for the best]]]]. (Naturally, in the cursed Storybrooke, Ruby was also apparently raised by her grandmother.)
* In ''Series/RaisingHope'', Jimmy's mother Virginia was raised by her grandparents after her mother abandoned her, but was told that her mother had died. Jimmy also made a will that said that if he were to die, his parents would be first in line to be his daughter Hope's legal guardians. Lucy's parents also kidnap Hope so they can do this, though she is returned by the end of the episode.

* In the Music/SufjanStevens song "Romulus", the narrator and his brother are left in grandpa's care by their mom, who they apparently don't see again until Grandpa's funeral many years later.
* Music/PeterAndTheWolf doesn't mention whether Peter's parents are around or not, but the only parental figure shown is his grandfather.

[[folder:Tabletop Games]]
* Eric Donner, a sample character in ''TabletopGame/{{Scion}}', was raised by his grandfather, as his father (the god Thor) wasn't part of his life and his mother died young from complications from delivering Eric. (It wasn't DeathByChildbirth, as she lived for several years following the birth.)

[[folder:Video Games]]
* ''Franchise/FinalFantasy''
** Krile from ''VideoGame/FinalFantasyV'' is taken care of by her grandfather Galuf after her parents' disappearance.
** Relm of ''VideoGame/FinalFantasyVI''. However, Strago is more of an adopted grandfather (it's not made entirely clear).
* ''VideoGame/HarvestMoon'':
** Chloe in ''VideoGame/HarvestMoonTreeOfTranquility'' and ''VideoGame/HarvestMoonAnimalParade'' is raised by her grandfather, Ramsey.
** In ''VideoGame/HarvestMoonFriendsOfMineralTown'' and the female equivalent, May is raised by her grandfather Barley, though it's suggested in a couple of events that her mother is still alive. Also, Stu is raised by his sister, Elli, who appears to have been raised by their grandmother, Ellen. In ''VideoGame/{{Harvest Moon 64}}'' it was mentioned that Elli's parents died when she was little and Ellen had to raise her.
** ''VideoGame/StoryOfSeasonsTrioOfTowns'':
*** Ludus was raised by his grandmother, Tototara. His parents left Lulukoko several years ago and haven't been back.
*** Iluka and Siluka are [[HappilyAdopted adopted grandchildren]] of Tototara's and were raised by her, after their parents dropped them off in Lulukoko one day and never came back.
*** Yuzuki was raised by his grandparents, after his parents [[ParentalAbandonment dropped him off there as a baby because of his sickly constitution]].
* ''VideoGame/DeadOrAlive'': Gen Fu is fighting to save the life of his granddaughter, whom he raised himself.
* ''Franchise/TheLegendOfZelda'':
** While not his Biological Grandparents (assumingly, as they're described as "surrogate mother[s]" but nothing more specific is said), according to ''VideoGame/TheLegendOfZeldaOcarinaOfTime'', Ganondorf was raised by the sisters Twinrova, who are far older then him and fit the dynamic nicely.
** In ''VideoGame/TheLegendOfZeldaTheMinishCap'', Link lives with his grandfather, the master blacksmith of Hyrule.
** In ''VideoGame/TheLegendOfZeldaTheWindWaker'', Link and his sister Aryll are raised by their grandmother.
** In ''VideoGame/TheLegendOfZeldaBreathOfTheWild'', Paya is implied to have been raised by her grandmother Impa.
* Naoto Shirogane from ''VideoGame/{{Persona 4}}'' claims "Grandpa" as the main parental figure.
* ''VideoGame/FireEmblem'':
** Saleh and Lute from ''VideoGame/FireEmblemTheSacredStones'' were raised by their respective grandmothers. Saleh is an orphan, Lute's parents are WalkingTheEarth.
** Subverted with Lyn from ''[[VideoGame/FireEmblemElibe Rekka no Ken]]'', since she came to live with her grandfather only when she was in her mid-late teens and had been living alone for a bit after her parents (and whole tribe) died. Played straighter with [[spoiler: Canas's son Hugh]] from the prequel; he was raised by his grandmother [[spoiler: Niime]] since his parents died [[spoiler: protecting their village from a snowstorm]].
** In ''[[VideoGame/FireEmblemAkaneia New Mystery of the Emblem]]'', [[HelloInsertNameHere My Unit]] can have various backgrounds chosen by the player, such as being the child of a merchant or a noble house, or perhaps an orphan; however, this simply affects their base stats, and no matter what, circumstances force them to be raised by their grandfather, who trains them from a young age to be an Altean knight.
** Alm, the hero of ''VideoGame/FireEmblemGaiden'', believes this to be the case at the start of the game, though the villains know that Mycen never had any children and therefore cannot possibly be Alm's biological grandfather. [[spoiler:He's actually the heir to the kingdom of Rigel; King Rudolf asked Mycen to raise him.]]
* Mai Shiranui from ''VideoGame/FatalFury'' and ''VideoGame/TheKingOfFighters'' is hinted to have lived like this too, since her only mentioned relatives are her grandfather and trainer Hanzou and her dead grandmother. The hairpin that she wears is hinted to be a TragicKeepsake from said grandma. [[spoiler: According to Mai and Takuma's intro conversation in ''KOF XIII'', Hanzou Shiranui recently passed away. Takuma straightforwardly asks Mai if she and Andy are up for the challenge of keeping up with the Shiranui school of ninjitsu now that Hanzou is gone, and Mai calmly tells him not to worry since they're ready for it.]]
* ''Franchise/{{Pokemon}}'':
** This seems to be the case for Blue and his sister Daisy in ''VideoGame/PokemonRedAndBlue'', as their parents are never brought up, only their grandfather Professor Oak.
** It's mentioned in ''VideoGame/PokemonDiamondAndPearl'' that the BigBad Cyrus was raised by his grandparents.
** Hapu from ''VideoGame/PokemonSunAndMoon'' was raised by her grandparents.
* VideoGame/GabrielKnight was raised by his paternal grandmother; his parents died when he was still a baby.
* Kainé in ''VideoGame/NieR'' was raised by her grandmother following her parents' deaths.
* Mars in ''VideoGame/ShiningWisdom'' is raised and trained to be a knight by his two grandparents after his father (a famous knight) succumbed to the poison inflicted on him in a great battle with a dragon.
* ''VideoGame/LaMulana'''s Lemeza Kosugi was raised by his grandfather after his father abandoned him to go looking for the ruins of La-Mulana. Naturally, Lemeza respects his grandpa a lot more than his dad.
* Alex Roivas of ''VideoGame/EternalDarkness'' lost her parents to a car accident; her grandfather Edward raised her until she moved away to go to college in Washington state, though he never told her about their family history before he dies under unusual circumstances, prompting her to return and investigate.
* Catherine "Cathy" King of ''VideoGame/CriminalCase'' is implied to have been raised by her grandfather, Chief Samuel King. No word on where her parents are, or what happened to them.
* Alex in ''VideoGame/StardewValley'' lives with his maternal grandparents, George and Evelyn. If you develop a sufficiently strong bond with him, he explains that [[spoiler:his abusive father walked out on him and his mom, and she died of sickness shortly thereafter]]. Also, Jas lives with her godfather Shane and his aunt Marnie.
* Nakmor Drack in ''VideoGame/MassEffectAndromeda'' raised his granddaughter Kesh himself. He prefers not to talk about what happened to Kesh's parents and grandmother.
* Maria Robotnik from ''Franchise/SonicTheHedgehog'' was an IllGirl in the custody of her grandfather Gerald Robotnik on a spaceship. Her parents are never referenced. After Maria was killed, Gerald underwent a VillainousBreakdown.

[[folder:Visual Novels]]
* In ''VisualNovel/LittleBusters'', Kud's mother was a busy cosmonaut, so she was raised primarily by her grandparents.
* In ''VisualNovel/UminekoWhenTheyCry'', the audience finds out early on that Battler Ushiromiya had a [[ParentWithNewParamour falling-out with his father Rudolf]] about six years before the story started, and so from the age of twelve until relatively recently, was living with his maternal grandparents.
* [[BornDetective Kyouko Kirigiri]] in ''VisualNovel/{{Danganronpa}}'', due to her father walking out from the family of business detective-work. She claims to be glad about that, saying she'd probably never become the GreatDetective she is now (or a detective at all, for that matter) if he'd taken her with him.

[[folder:Web Comics]]
* Webcomic/{{Sheldon}} lives with his grandfather.
* Jade from ''Webcomic/{{Homestuck}}'' seems to have been raised by her grandfather. [[spoiler: Until he died, of course. Now her Guardian is Bec.]]
** Turns out that [[spoiler:He's actually her biological father]].
** Also, Jake was raised by [[spoiler:Jade until she died.]]

[[folder:Web Original]]
* In ''Franchise/{{Noob}}'', Sparadrap and his younger brother were raised by their grandmother. Between Sparadrap being a ManChild and his brother still being in high school in Season 2 (but eighteen in the second novel), both are still living with her. Sparadrap mentions that their father is a priest a handful of times in the webseries, but [[MissingMom their mother has yet to be mentioned or seen in any media]].

[[folder:Western Animation]]
* In ''WesternAnimation/HeyArnold'' (which provides the page image), Arnold lives with his paternal grandparents, who are the landlords of a quirky boarding house. This went unexplained until the episode "Parents Day," when we learn that his parents, Miles and Stella, disappeared on a humanitarian mission in South America. Later episodes and ''WesternAnimation/HeyArnoldTheJungleMovie'' explore the issue in more detail. Interestingly, although Arnold's father Miles was apparently an only child, his mother Stella has at least one sibling, the parent of Arnold's weird cousin Arnie. This aunt or uncle only exists by inference, however, as he or she isn't seen or even mentioned in either of Arnie's two appearances on the show.
* Max Tennyson in ''WesternAnimation/{{Ben10}}''. With all they've gone through together, there's not much more raising those kids' parents can do.
* [[WesternAnimation/{{Metalocalypse}} William Murderface]]. [[RuleOfThree Murderface, Murderface]].
* The Tibbles from ''WesternAnimation/{{Arthur}}'' are raised by their grandmother.
* Applejack, Apple Bloom and Big Macintosh from ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' are under the care of Granny Smith. Possibly applies more to the elder siblings given Granny's ailing health, which may or may not include the early stages of dementia; Apple Bloom was probably raised more by [[PromotionToParent her older siblings]]. Canon has yet to explicitly address the question of what happened to their parents.
** WordOfGod says that a pair of shooting stars AJ sees in Apple Family Reunion represent her parents, who are in fact deceased. In Season 5, Applejack wishes "Mom and Dad could be here" when Apple Bloom [[spoiler: gets her cutie mark]].
*** And in the Season 7 episode "The Perfect Pear", it's heavily implied that their parents indeed have passed away.
* Huey and Riley Freeman in ''WesternAnimation/TheBoondocks''. Various news reports and other official statements treat "Granddad" as if it were Robert Jebediah "Mr. Bitches" Freeman's actual first or middle name. Even ''he'' does it. Huey and Riley's parents are stated to be dead (Robert spent their inheritance on the house), the anime suggests they have no aunts or uncles, so he is the closest person left to take care of them.
* ''WesternAnimation/DuckTales1987''. Webby Vanderquack is being raised by her grandmother Mrs. Beakley. Upon her grandmother getting hired as the maid and nanny to Huey, Dewey, and Louie, their great uncle Scrooge [=McDuck=] becomes a surrogate uncle and grandfather figure to her as well. Scrooge even asks Webby to call him Uncle Scrooge instead of Mr. Scrooge.
** The triplets themselves and Great Uncle Scrooge are a variation of this. They are being cared for by him while their uncle Donald Duck, who had been [[ParentalSubstitute their guardian and de facto father]] was serving in the Navy.
** In the [[WesternAnimation/DuckTales2017 reboot]] the same applies to Webby, who has been raised by Mrs. Beakley in Scrooge's mansion. Not so much for the triplets, since their uncle has been their actual parental figure and still is active in their lives as in the comics.
* On ''WesternAnimation/GravityFalls,'' [[OneOfTheKids Soos]] appears to have been raised primarily by his maternal grandmother (referred to as "Abuelita"), and has at least been living with her since his 12th-birthday. It's never explained what happened to Abuelita's daughter (Soos' mother), [[DisappearedDad but it's mentioned that Soos hasn't seen his dad since he was at least four.]]

[[folder:Real Life]]
* UsefulNotes/GeorgeWashington -- The very first president of the United States ended up raising two of his (step)grandchildren.
* Clarence Thomas wrote a memoir called ''My Grandfather's Son.'' Its title refers to the fact that he only met his father once, with his maternal grandfather serving as his primary ale role model growing up.
* Ted Bundy's mother gave birth to him at a young age, and he was raised as her brother rather then her son.
* Professional wrestler Arn Anderson was raised by his grandparents, as his father took off when he was an infant and his mother was a screw-up who had enough trouble taking care of herself.