So, you've got a SuperSoldier program, perhaps an AI research initiative, an organization that has access to all sorts of {{Phlebotinum}} goodness for its operatives, or some other cutting edge experiment designed to [[ScaleOfScientificSins alter]] or CreateLife.

One small problem. The first test subject, AI, or robot off the assembly line isn't just a SuperPrototype, it's ''[[WithGreatPowerComesGreatInsanity completely insane.]]''

Maybe [[Film/{{Ghostbusters}} the streams crossed]], the SuperSerum is actually of the [[PsychoSerum Psycho]] or [[ToxicPhlebotinum Toxic]] flavors, the janitor [[BullyingADragon tossed rotten tomatoes at it]], the psych evaluations weren't [[CriticalPsychoanalysisFailure as rigorous]] as they should have been, or an honest to goodness [[DidntSeeThatComing unforeseen complication]] happened during Alpha Testing (if there was any, that is). Whatever the case, the experiment has GoneHorriblyWrong and the first and eldest of a nascent [[TheChosenMany Chosen Many]] has gone rogue [[PhlebotinumRebel (and not in the good way)]], is evil, and likely wants to kill its makers ''and'' younger siblings.

More chillingly, it is the result of an experiment that has GoneHorriblyRight. The prototype is ''so'' powerful and ''so'' good at what it does that its makers cannot control or influence it. Its going to do whatever it wants, often violently.

This tends to happen ''very'' frequently to projects started by altogether good conspiracies who want to [[MassSuperEmpoweringEvent create an army of heroes]]. By the time they get around to perfecting the process and the hero undergoes it, "big brother" will show up and either [[CirclingMonologue "offer"]] to form a SecretProjectRefugeeFamily after killing their "parents"... or kill him dead if he refuses. Inevitably, any previous version of a hero who reappears is invariably evil.

Expect this monster to be named some variation of Alpha, Proto, or [[MyHeroZero Zero.]]

Contrast EvilKnockoff, NoPlansNoPrototypeNoBackup. Parent Trope of BetaTestBaddie. See also FlawedPrototype.
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!!Examples:

[[foldercontrol]]

[[folder: {{Anime}} and {{Manga}}]]
* In the ''VideoGame/ZoneOfTheEnders'' {{Prequel}} ''Idolo'', the Metatron used to power the [[HumongousMecha Orbital Frame]] is a slow acting, [[ArtifactOfDoom sentient]] PsychoSerum. It turns the pilot, Radium Levans, into a hateful and destructive force, while enabling him to use Idolo's powers to their destructive apex.
* Hidan from ''Manga/{{Naruto}}''; his inability to die resulted from a religious experiment. Only problem is, the god of said religion praises the slaughter of one's neighbors, which didn't bode well for Hidan's village (or anyone else for that matter).
* Some incarnations of Atlas from ''Anime/AstroBoy''. He was created before Astro and his ''kokoro'' program turned dark from neglect and teenager rebellion.
* The Mad Pierrot from ''Anime/CowboyBebop'' killed everyone involved with the project and then killed everyone else that laid eyes on it. This is because the super empowering regressed his mind to that of a child.
* The Prototype and Test Type models 00 and 01 of ''Anime/NeonGenesisEvangelion''. 01 is a bloodthirsty MamaBear when it comes to her pilot, and 00 ''actively attempted (and [[BandageBabe failed]]) to kill hers''.
* The ZERO System from ''GundamWing'' may qualify. A combat system created for the SuperPrototype Wing Zero, it feeds an incredible amount of battle data and suggested courses of action directly into the pilot's brain. The problem being that using it requires exceptional mental focus: if your mind drifts even a little, it causes a slippery slope chain reaction that leads to the pilot being driven insane (either temporarily or permanently based off their mental fortitude). Throughout the series, all the main characters use it but only TheHero and TheRival are considered to have "mastered" it (though TheHeart comes close).
* The Extended of ''GundamSEEDDestiny'' were pretty crazy, but when compared to their predecessors, the pre-Extended or biological [=CPU=]s, they're pillars of mental stability. The Extended can fake being normal. The pre-Extended were too AxeCrazy to so much as cooperate with one another, let alone be entrusted with spy missions.
** On the other hand, while the Biological [=CPU=]s were crazier than the Extended, they were much stronger and more skilled, giving SEED Mode users a run for their money.
[[/folder]]

[[folder:Comic Books]]
* CaptainAmerica originally inverted this trope, with a number of his villains created by attempts to duplicate his Super Soldier Serum. Eventually, Protocide was introduced via RetCon, thereby playing this trope straight.
* Obviously, NormanOsborn, ''{{Spider-Man}}'' foe.
** Inverted in [[UltimateMarvel Ultimate Spider-Man]] with [[SpiderMan Peter Parker]] being ''bitten'' by the accidental prototype, and Normal Osborn attempting to replicate the success by injecting himself with the OZ Serum.
* Everyone in the [[{{Marvel}} Weapon Plus]] programme except {{Wolverine}} and CaptainAmerica qualifies. The rest were super-villains and each was the first, and often only, in their generation of the programme.
* Valentine Romanov, eldest brother of ''NikolaiDante'', was the first Romanov to be bonded with a weapons crest. Unfortunately, his was a prototype which caused [[BodyHorror massive scarring, making him resemble a metallic skeleton]] along with some ''major'' SanitySlippage.
* The process that gave [[{{LukeCageHeroForHire}} Luke Cage]] his steel skin was used earlier in the Vietnam on a soldier who called himself Warhawk.
* The first story arc of ''The Bionic Man'' (the comic reboot of ''Series/TheSixMillionDollarMan'') had the BigBad be the OSI's first attempt at bionic enhancement, a war-hero soldier who went nuts due to unanticipated poisoning caused by the implants.
[[/folder]]

[[folder:Film]]
* While Ash the android didn't technically go insane in ''Film/{{Alien}}'', it did engage in homicidal behavior, unlike the more "stable" later version represented by Bishop in ''Film/{{Aliens}}''. Also, Ash "malfunctioning" is merely the official explanation to cover up that [[spoiler: he was fulfilling his mission to get the Xenomorph back to Earth without the interference of the crew]].
* Johann Schmidt[=/=]RedSkull in ''Film/CaptainAmericaTheFirstAvenger'' was this compared to Captain America, receiving the same serum. It made him physically stronger, but also drove him insane and deformed him as a result. Dr. Erskine, the serum's designer, explained it by saying Schmidt was ''already'' evil and the serum only made him more so.
** This is also the case in ''Film/CaptainAmerica1990'', the first theatrical film adaptation: in that version, he's a former child prodigy upon whom the doctor who developed the SuperSerum was forced to experiment...before she'd finished fixing the grotesque physical side-effects. (How much of his insanity is due to the prototype serum, which supposedly "increases aggression," and how much is due to being abducted from his family and [[RaisedByOrcs raised by Nazis]], is left up in the air.)
* Albert Wesker from the ''Film/ResidentEvil'' films is implied to be this to Alice. Like Alice, he is injected with the T-Virus, and it is strongly implied that Wesker was injected long before Alice was. Likewise, after surviving a huge explosion, he regularly [[ImAHumanitarian commits cannibalism]] in order to keep an imbalance of the T-Virus at bay as a result of the stress of surviving the explosion.
[[/folder]]

[[folder:Literature]]
* This is the case with [[spoiler: Mercutio]] in ''Literature/{{Idlewild}}'' by Nick Sagan. While he's not the alpha himself, the prototype's bitterness and jealousy bled into him and he goes insane. Eventually he kills several of his supposed friends as his grip on reality (such as it is in this MindScrew of a book) slackens.
** In the third book in the series, "Everfree", one of the [[spoiler:thawed-out Gedaechtnis employees admits to tampering with Mercutio's DNA to make him more dominant, because he was the only pure white subject.]]
* In TadWilliams' ''Literature/{{Otherland}}'' series, Mr. Sellars' backstory involves a secret military program to develop PoweredArmor - one of the soldiers being trained for the program was mentally unstable and went on a psychotic rampage in a prototype suit, destroying billions of dollars of equipment and killing nearly all of his fellow personnel. Sellars himself barely survived, with horribly disfiguring injuries. The project was supposedly scrapped as a result of this incident, though Sellars notes that modern combat gear incorporates similar technology, albeit in a less OneManArmy form.
* A textbook example of this trope occurs in the DeanKoontz novel Mr. Murder, even having the superhuman clone assassin named Alpha. It is explained that their attempts to make him asexual just resulted in him being extremely sexually frustrated, as well as homicidal.
* The FactionParadox novel ''Of the City of the Saved'' features Antipathy, the AxCrazy firstborn son of the humanoid TARDIS Compassion. A psychotic TARDIS is a scary, scary thing.
* ''Literature/LegacyOfTheDragokin'': Daniar and her siblings were not [[BigGood Dronor's first attempt]] at creating human/dragon hybrids. Those were the mara; a race of superhumans that lived only to torture men.
[[/folder]]

[[folder:Live Action TV]]
* Sara Corvus, the self-proclaimed "first" bionic woman in the ''Series/BionicWoman'' series.
* Sylar/Gabriel Grey in ''Series/{{Heroes}}'' started out as this. He was [[MyHeroZero Patient Zero]] to Dr. Chandra Suresh, and it's partly due to Gabriel's desire to prove to him that he was special that drove him to start killing people and taking their powers. However, later {{RetCon}}s have shown or implied that his [[AxCrazy Ax Craziness]] is also due to a couple other factors including [[WithGreatPowerComesGreatInsanity his ability]], [[InTheBlood his biological father]], and some pretty serious childhood trauma among other things. So the guy didn't exactly have the stablest psyche ''before'' encountering Dr. Chandra Suresh.
* Lore (prototype for Data) in ''Series/StarTrekTheNextGeneration ''.
* KARR (prototype for KITT) from ''KnightRider''.
** Knight Rider sequels follow the KARR formula. In Team Knight Rider the TKR AI car prototype KRO went crazy because his driver was crazy. In Knight Rider 2008 the second KITT had to face his own KARR predecessor which can transform to a robot. KARR (Knight Automated Roving Robot), KRO (Knight Reformulation One) and KARR 2008 (Knight Auto-Cybernetic Roving Robotic-Exoskeleton) are all prototypes that went rogue.
* [[spoiler: Number One, "Cavil"]] from ''Series/{{Battlestar Galactica|Reimagined}}''. [[spoiler: As the first of the new humanoid Cylons made by the Final Five, he exhibited bitterness at not being 100% machine, envy of his brothers and sisters (even entirely destroying the Sevens) and a deep desire for his creators to come around to his genocidal viewpoint to the point where he reprograms them to think they're humans and launches a genocidal attack on humanity.]] And those are just ''some'' their sins. Chiefly, this Cylon's actions resulted in the near genocide of the human race.
* ''Series/{{Firefly}}'s'' River Tam is the most advanced and successful version of the psychic assassins produced by the Academy, and while it isn't stated outright, both River and the methods used to create her have all the trappings of a prototype, including uncertain technology, unpredictable side effects, and crippling flaws. Naturally, River is also insane.
* Adam from ''Series/BuffyTheVampireSlayer''. The very first thing he does when he awakes is kill his creator.
* In ''Series/{{NCIS}}'' it was revealed that [[spoiler:the Port-to-Port Killer was the first and last product of an experimental [=CIA=] training program, intended to transform servicemen into assassins. After his only sanctioned kill, he promptly went serial-killer using his spook/military training and a handy folder of fake passports]].
[[/folder]]

[[folder:Video Games]]
* ''Franchise/FinalFantasy'' LOVES villains with this backstory.
** In ''VideoGame/FinalFantasyVI'', talking to an NPC in the Empire's capital city will reveal that Kefka was the first {{Magitek}} [[SuperSoldier knight]] created by TheEmpire, and he was driven insane by the process. (Luckily, they got it right with Celes.)
** Kuja from ''VideoGame/FinalFantasyIX'' is this in addition to a FlawedPrototype (albeit, ''intentionally'' flawed).
** ''VideoGame/DissidiaFinalFantasy'' reveals that [[spoiler:''[[VideoGame/FinalFantasyI Garland]]'']], of all villains, was one. He was a SuperPrototype, too; his powers were once strong enough to defeat [[ThatOneBoss Omega]] and all the summoned beasts in his world.
** In ''VideoGame/FinalFantasyVII'', Sephiroth was the prototype of the [[MegaCorp Shinra]] program that would eventually develop [[SuperSoldier SOLDIER]]; while he was extremely well-behaved for a time, discovering the secrets behind his creation [[GoMadFromTheRevelation drove him mad]] and turned him into the greatest threat to life the Planet had ever seen.
** The ''VideoGame/FinalFantasyVII'' prequel ''VideoGame/CrisisCore'' has [[spoiler: Genesis Raphsodos]] who also qualifies as a FlawedPrototype. Unlike Sephiroth, he was emotionally unstable to begin with, and only gets worse when he discovers [[spoiler: that he was not only a failure from a project intended to compete with the one that spawned Sephiroth, but also [[PowerDegeneration deteriorating at a high rate.]]]]
* ''[[VideoGame/FirstEncounterAssaultRecon F.E.A.R.]]'' Series:
** ''FEAR'' oddly messes with this, the first prototype ([[spoiler:the pointman]]) is considered a failure, the second prototype ([[spoiler:Paxton Fettel]]) is the one who cause problems, but only with a little help from his mum.
* [[spoiler:Nebilim]] from ''VideoGame/TalesOfTheAbyss'': The first [[spoiler:human replica]], and [[CameBackWrong utterly insane]]. Then again, its creator wasn't [[{{Necromantic}} entirely stable-minded]] when he created it either.
* Doctor Light was terrified of [[VideoGame/MegaManX X]] becoming this, which is he sealed him away for 30 years to test his morality.
** Inverted with Axl: he was a prototype to the transforming next-generation Reploids, yet he himself is quite sane (even if he has a slight BloodKnight nature to him). It's the mass produced versions that were insane.
* ''VideoGame/KillingFloor'' the clot is a prototype clone of Kevin's dead son. It had all the natural traits of a zombie, aggressive, bloodthirsty and cannibalistic.
* Downplayed with Jack, aka Subject Zero, in ''VideoGame/MassEffect2'': she's not so much psycho as just really, ''really'', '''really''', '''''[[HairTriggerTemper REALLY]]''''' angry.
** ... and [[BrokenBird emotionally unstable]]. Grunt also comes across as a Pscyho Prototype at first, but is actually "just" a [[DesignerBaby vat-bred]] BloodKnight who takes the [[ProudWarriorRace Krogan]] love of violence and turns it UpToEleven.
* The Biolizard in ''SonicAdventure2''.
* In ''VideoGame/StarcraftII'', Spectres were a brief program run by Mengsk to create a new breed of more powerful psychic assassins, replacing the original Ghost units seen throughout ''VideoGame/{{Starcraft|I}}''. Nova, a Dominion-loyalist Ghost, claims the project was shut down and the Spectres imprisoned because they were psychotic killing machines.
** [[spoiler: However, if the player takes the "Breakout" mission, which has been stated to be the canonical mission, then they learn that Nova was basically lying and Spectres are no more prone to going mad than Ghosts are, if less. The real reason the project was abandoned was because the power-boost that made a Ghost into a Spectre let them blow out their {{Restraining Bolt}}s.]]
*** Then again their [[StopPokingMe unit quotes]] seem to suggest that they are indeed a bit flaky.
-->[[http://www.youtube.com/watch?v=tKEe0jPdHi8 "I can taste your mind... Mmm, salty!"]]
* Prototype Jack in ''VideoGame/{{Tekken}} 1'' is designed to be a super powerful robot that's gone haywire and its owner has lost control of it. The one in 2 and Tag Tournament is more of an army drone and so isn't as evil as it's just following orders.
* Alpha in ''VideoGame/MegaManBattleNetwork 3'' is the prototype of ''the Internet itself'' given form and AI.
[[/folder]]

[[folder:Webcomics]]
* ''AntiheroForHire'': [[spoiler:[[http://www.antiheroforhire.com/d/20050228.html Wizard]]]]
[[/folder]]

[[folder:Western Animation]]
* Proto Man, but only in the ''WesternAnimation/MegaMan'' animated series. In the games he's more of an AloofBigBrother; he also has some kind of design flaw in his power plant or buster that can prove fatal, and means he has less health.
* Earl, Rusty's "older brother" from ''WesternAnimation/BigGuyAndRustyTheBoyRobot'' isn't exactly crazy, but his AI is woefully incomplete and he's a very angry kid. Basically, take [[Anime/AstroBoy Atlas]], [[FullMetalJacket Gunnery Sargeant Hartmann]] and RainMan, then put them in a blender and hit puree.
* Protoform X, from ''WesternAnimation/BeastWars'': the AxCrazy Rampage. He was created by Maximal Scientists (attempting to duplicate Starscream's annoying ability to not stay dead) as an immortal supersoldier. What they got was a psychotic killing machine that massacred them and the rest of the colony they were on. Also, [[GoneHorriblyRight he was an immortal supersoldier.]]
* XL from ''WesternAnimation/BuzzLightyearOfStarCommand'' was built before XR; XL had villainous inclinations.
* ''WesternAnimation/{{Robotboy}}'' had Protoboy, Robotboy's older brother who was captured and turned into an OmnicidalManiac by Dr. Kamikazi. He would go to various lengths to attempt to prove he's Professor Moshimo's best invention/kill him, including [[GrandTheftMe switching his motherboard with his brother]] so he can get close to Moshimo and later threatening to kill Moshimo in a robot factory by pouring molten titanium on him unless Robotgirl offers to take his place. While he had a penchant for coming back to life after being blown up he's supposedly KilledOffForReal in the aforementioned factory.
* ''WesternAnimation/WinxClub'''s Valtar was somewhat of this to Bloom. He was born of the same element that makes up her magic, but was raised by the Ancestral Witches (the ancestors of the Trix) and ended up participating in the attack that destroyed Domino and caused her to be raised on Earth. Part of Season Three's storyline involves the Winx tracking down a set of items made to take down someone with Bloom's power so that they can use them on him; that's how bad he is.
[[/folder]]

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