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[[quoteright:751:[[ComicBook/CaptainAmerica https://static.tvtropes.org/pmwiki/pub/images/protocide.png]]]]
[[caption-width-right:751:If ComicBook/CaptainAmerica is the American dream, then this is the American nightmare]]

So, you've got a SuperSoldier program, perhaps an AI research initiative, an organization that has access to all sorts of {{Phlebotinum}} goodness for its operatives, or some other cutting edge experiment designed to [[ScaleOfScientificSins alter]] or CreateLife.

One small problem. The first test subject, AI, or robot off the assembly line isn't just a SuperPrototype, it's ''[[WithGreatPowerComesGreatInsanity completely insane]].''

Maybe [[Film/Ghostbusters1984 the streams crossed]], the SuperSerum is actually of the {{Psycho|Serum}} or {{Toxic|Phlebotinum}} flavors, the janitor [[BullyingADragon tossed rotten tomatoes at it]], the psych evaluations weren't [[CriticalPsychoanalysisFailure as rigorous]] as they should have been, or an honest to goodness [[DidntSeeThatComing unforeseen complication]] happened during Alpha Testing (if there was any, that is). Whatever the case, the experiment has GoneHorriblyWrong and the first and eldest of a nascent [[TheChosenMany Chosen Many]] has gone rogue ([[PhlebotinumRebel and not in the good way]]), is evil, and likely wants to kill its makers ''and'' younger siblings.

More chillingly, it is the result of an experiment that has GoneHorriblyRight. The prototype is ''so'' powerful and ''so'' good at what it does that its makers cannot control or influence it. It's going to do whatever it wants, often violently.

This tends to happen ''very'' frequently to projects started by altogether good conspiracies who want to [[MassSuperEmpoweringEvent create an army of heroes]]. By the time they get around to perfecting the process and the hero undergoes it, "big brother" will show up and either "[[CirclingMonologue offer]]" to form a SecretProjectRefugeeFamily after killing their "parents"... or kill him dead if he refuses. Inevitably, [[HerosEvilPredecessor any previous version of a hero who reappears is invariably evil]].

Expect this monster to be named some variation of Alpha, Proto, or [[MyHeroZero Zero]].

Compare HerosEvilPredecessor. Contrast EvilKnockoff, NoPlansNoPrototypeNoBackup. Parent Trope of BetaTestBaddie. See also FlawedPrototype.
----
!!Examples:

[[foldercontrol]]

[[folder:Anime & Manga]]
* Some incarnations of Atlas from ''Anime/AstroBoy''. He was created before Astro and his ''kokoro'' program turned dark from neglect and teenager rebellion.
* Mad Pierrot from the ''Anime/CowboyBebop'' episode "[[Recap/CowboyBebopSession20PierrotLeFou Pierrot le Fou]]" kills everyone involved with the project and then kills everyone else who laid eyes on it. This is because the process that empowered him regressed his mind to that of a child.
* ''Manga/FullmetalAlchemist'' has the old men who, as boys, were used in an attempt to create a host for Wrath. Not that Führer King Bradley (the final product) isn't a psycho himself, but these guys are more disturbing. They weren't strong enough to withstand the conversion process, which left them as mindless shells of men - ''who will still try to kill you''.
* Come to think of it, ''Franchise/{{Gundam}}'' has a lot of these.
** The first known example would be the EXAM system, which is noted to be extremely unstable and hard-to-control, with mobile suits equipped with it known to have gone berserk with extended usage, and that's all without mentioning that the primary component of the thing is a [[PoweredByAForsakenChild Newtype's [=SOUL=].]]
** Then there's the HADES system, which forcibly overclocks the Mobile Suit's performance, and that's on top of the fact that it was still prone on going berserk in the middle of battle. Hell, to even pilot a HADES-equipped machine required extensive augmentations.
** The NT-D system arguably qualifies for this as well - its full name is the Newtype Destroyer system, and will forcibly activate in the presence of Newtype brainwave activity. The main problem? Well, first off, a pilot lacking sufficient mental fortitude will end up getting overwhelmed by the system and pretty much end up as a WetwareCpu for the five minutes the system is active. There's also the fact that the system requires a large psychoframe to be integrated into the machine itself. While it does allow the pilot to control the machine by thought alone, it comes with the side effect of both amplifying the pilot's emotions as well as making them extremely hypersensitive. Case in point, activation of NT-D made Riddhe even more unstable than he already was, and something as simple as his Beam Magnum accidentally bumping the arm of his MS was enough to make him completely lose it.
* The [=EB-AX2=] Graze Ein of ''Anime/MobileSuitGundamIronBloodedOrphans'' is the result of Gjallarhorn's secret advocation to bionic augmentation, equipped with triple Ālaya-Vijñāna Systems, [[DualWield dual]] axes, {{Pile Bunker}}s and [[ThisIsADrill drill feet]]; the price of such creation is the heavy toll on the [[WithGreatPowerComesGreatInsanity pilot's sanity]], [[spoiler: although the pilot, Ein Dalton, was [[RevengeBeforeReason already insane to begin with]].]]
* The Extended of ''Anime/MobileSuitGundamSEEDDestiny'' were pretty crazy, but when compared to their predecessors, the pre-Extended or biological [=CPU=]s, they're pillars of mental stability. The Extended can fake being normal. The pre-Extended were too AxeCrazy to so much as cooperate with one another, let alone be entrusted with spy missions.
** On the other hand, while the Biological [=CPU=]s were crazier than the Extended, [[SuperPrototype they were much stronger and more skilled]], giving SEED Mode users a run for their money.
* The ZERO System from ''Anime/MobileSuitGundamWing'' may qualify. A combat system created for the SuperPrototype Wing Zero, it feeds an incredible amount of battle data and suggested courses of action directly into the pilot's brain. The problem being that using it requires exceptional mental focus: if your mind drifts even a little, it causes a slippery slope chain reaction that leads to the pilot being driven insane (either temporarily or permanently based off their mental fortitude) and concluding that [[OmnicidalManiac killing everything]] is the best way to eliminate all threats. Throughout the series, all the main characters use it but only TheHero and TheRival are considered to have "mastered" it (though TheHeart comes close and the girl who was already a little unhinged might have been driven ''sane'' by it).
* Hidan from ''Manga/{{Naruto}}''; his inability to die resulted from a religious experiment. Only problem is, the god of said religion praises the slaughter of one's neighbors, which didn't bode well for Hidan's village (or anyone else for that matter).
* The Prototype and Test Type models 00 and 01 of ''Anime/NeonGenesisEvangelion''. 01 is a bloodthirsty MamaBear when it comes to her pilot, and 00 ''actively attempted to kill hers''.
* In the ''VideoGame/ZoneOfTheEnders'' {{prequel}} ''Idolo'', the Metatron used to power [[HumongousMecha Orbital Frames]] is a slow acting, [[ArtifactOfDoom sentient]] PsychoSerum. It turns the pilot, Radium Levans, into a hateful and destructive force, while enabling him to use Idolo's powers to their destructive apex.
[[/folder]]

[[folder:Comic Books]]
* The first story arc of ''The Bionic Man'' (the comic reboot of ''Series/TheSixMillionDollarMan'') had the BigBad be the OSI's first attempt at bionic enhancement, a war-hero soldier who went nuts due to unanticipated poisoning caused by the implants.
* A subversion in ''ComicBook/TheBoys'', where the psycho isn't the prototype but the second one. [[spoiler:Black Noir is actually a clone of the Homelander, trained since birth to kill him if he gets out of control. Problem is, they can't just keep him on ice until needed, and the frustration of not being able to fulfill his only purpose in life makes him go nuts, committing atrocities while making the Homelander think he committed them, finally killing the Homelander once he goes off the deep end.]]
* ''ComicBook/CaptainAmerica'' originally inverted this trope, with a number of his villains created by attempts to duplicate his Super Soldier Serum. Eventually, Protocide was introduced via RetCon, thereby playing this trope straight.
* ''ComicBook/{{Hellboy}}'': Roger's "older brother" was a homunculus made by the same alchemist, obsessed with making himself a better body (by melting down humans into a giant) and achieve godhood. He almost succeeded before [[spoiler:Roger pulled a HeroicSacrifice by returning the fire he'd stolen from Liz Sherman, exploding the body]].
* The process that gave ''ComicBook/LukeCage'' his steel skin was used earlier in the Vietnam on a soldier who called himself Warhawk.
* Valentine Romanov, eldest brother of ''ComicBook/NikolaiDante'', was the first Romanov to be bonded with a weapons crest. Unfortunately, his was a prototype that caused [[BodyHorror massive scarring, making him resemble a metallic skeleton]] along with some ''major'' SanitySlippage.
* ''ComicBook/SpiderMan'': Obviously, ComicBook/NormanOsborn. He was already not a good person (being a CorruptCorporateExecutive), but the Goblin Serum created a completely AxeCrazy SplitPersonality, the Green Goblin.
** Inverted in [[ComicBook/UltimateMarvel Ultimate Spider-Man]] with [[ComicBook/SpiderMan Peter Parker]] being ''bitten'' by the accidental prototype, and Norman Osborn attempting to replicate the success by injecting himself with the OZ Serum.
* ''ComicBook/{{Superboy|1994}}'': Kon-El was designated "S-13" at Cadmus, in relation to being the thirteenth (and only successful) clone of ComicBook/{{Superman}} and while he does have to fight "S-01" once that's mostly over a misunderstanding due to S-01's lack of knowledge and Bizarro traits. The trope is inverted with him having to fight off the prideful amoral attempt to recreate him with improvements and more obedience named Match on multiple occasions.
* ''ComicBook/TheTransformersMegaseries:'' Monstructor, Jhiaxus' first attempt at building a combiner. Six minds forcibly mushed into one resulted in a super-strong and completely insane monster, who went on a rampage and had to be sealed away. Later on in IDW's Transformers stories, other combiners are created, and none of them are as unhinged as Monstructor. Of course, Jhiaxus being Jhiaxus, he doesn't see the problem with his creation being mad.
* Everyone in the [[Franchise/MarvelUniverse Weapon Plus]] programme(s) except ComicBook/{{Wolverine}} and ComicBook/CaptainAmerica qualifies. The rest were supervillains and each was the first, and often only, in their generation of the program. Some of them, especially among Wolverine's fellow Weapon X products, would eventually make a HeelFaceTurn, but [[ComicBook/{{Deadpool}} that didn't necessarily involve becoming any less psycho]].
* ''ComicBook/WonderWoman1987'': Dr. Lazarus' HardLight AI experiments are supposed to create constructs whose AI reflects the actions of whomever/whatever they're based on, however when it's used to create constructs based on superheroes those constructs are incredibly destructive, prone to casual murder and eager to attack other superheroes.
[[/folder]]

[[folder:Fan Works]]
* In ''Fanfic/{{Marionettes}}'' [[spoiler:King Longhorn and his crew, collectively known as [[MyHeroZero G5T00]]]], are this. [[spoiler:They're prototypes for the Fifth Generation Marionettes, but when deployed by the Stallions to test the Mane Six on dealing with a villain that acted within the law, they turned out much more violent, dangerous, and destructive than anyone intended and went on a rampage as a result.]]
* Inverted for ''Webcomic/MegaManDissonance'', in that it's the ''latest'' of Dr. Hook's creations (specifically, Requiem of the Element 5) that went out of control first.
* In the Anime/YuGiOhVRAINS fanfic ''Fanfic/ReCoded'', the Laplace [[spoiler:is actually created from Lightning, who becomes too intelligent for his own good and caused so many malfunctions that Dr. Kogami restructured Lightning to remove this part of his programming. Unfortunately, this part of him survived and Queen managed to extract it from Lightning to use it for her own ends.]]
[[/folder]]

[[folder:Film -- Live-Action]]
* ''Franchise/{{Alien}}'':
** While Ash the android didn't technically go insane in ''Film/{{Alien}}'', he engaged in homicidal behavior, unlike the more "stable" later version represented by Bishop in ''Film/{{Aliens}}''. Also, Ash "malfunctioning" is merely the official explanation to cover up that [[spoiler: he was fulfilling his mission to get the Xenomorph back to Earth without the interference of the crew]].
** ''Film/AlienCovenant'' introduces us to the Neomorphs and Prateomorphs, ancestors [[spoiler:(or imitations, based on the {{novelization}})]] of the classic Xenomorphs David created using Chemical A0-3959x.91 – 15. Both monsters are savage killing machines with wild temperaments even fiercer than their descendants/[[spoiler:inspirations]].
* In ''Film/CaptainAmerica1990'', the Red Skull is a former child prodigy upon whom the doctor who developed the SuperSerum was forced to experiment... before she'd finished fixing the grotesque physical side-effects. How much of his insanity is due to the prototype serum, which supposedly "increases aggression", and how much is due to being abducted from his family and [[RaisedByOrcs raised by Nazis]], is left up in the air.
* Johann Schmidt/Red Skull in ''Film/CaptainAmericaTheFirstAvenger'' is this compared to Captain America, receiving the same serum. It made him physically stronger, but also drove him insane and deformed him as a result. Dr. Erskine, the serum's designer, explains it by saying Schmidt was ''already'' evil and the serum only made him more so.
* ''Franchise/JurassicPark'':
** The ''[[NamesToRunAwayFromReallyFast Indominus rex]]'' from ''Film/JurassicWorld'' -- created to be the strongest dinosaur ever, she escapes from her cage and goes on a killing spree just because she can. [[spoiler:She was created as part of a plan to turn dinosaurs into {{living weapon}}s for the military.]]
** In the sequel, ''Film/JurassicWorldFallenKingdom'', a second, smaller hybrid is created from the ''Indominus'''s DNA known as the ''Indoraptor'', and like its predecessor, it's a sadistic murder machine that slaughters everything in its path ForTheEvulz. [[spoiler:However, this is deconstructed in-universe. Because the ''Indoraptor'' is a completely savage monster, it can't be used as a living weapon since [[FlawedPrototype it won't obey orders and can't be reliably controlled]]. This is what causes the scientist that created the ''Indoraptor'' to deem it a failure, and he wants the next generation of hybrids to be able to feel empathy and form bonds with its human trainers.]]
* Albert Wesker from the ''Film/ResidentEvilFilmSeries'' is implied to be this to Alice. Like Alice, he is injected with the T-Virus, and it is strongly implied that Wesker was injected long before Alice was. Likewise, after surviving a huge explosion, he regularly [[ImAHumanitarian commits cannibalism]] in order to keep an imbalance of the T-Virus at bay as a result of the stress of surviving the explosion.
[[/folder]]

[[folder:Literature]]
* The protomolecule hybrids from ''Literature/TheExpanse'' were created to be the ultimate shock troopers, but in practice, [[ImportedAlienPhlebotinum protomolecule technology]] proved to be little more than an advanced vector for [[TheCorruption spreading the protomolecule infection]].
* The ''Franchise/FactionParadox'' novel ''Of the City of the Saved'' features Antipathy, the AxCrazy firstborn son of the humanoid TARDIS Compassion. A psychotic TARDIS is a scary, scary thing.
* ''Literature/{{Idlewild}}'':
** This is the case with [[spoiler:Mercutio]] a.k.a. Adam in the first book. He is the firstborn of the Ten who are all experiments in genetic engineering and therefore a prototype. AI Malachi's bitterness and jealousy bled into Adam, and he went insane. Eventually, he kills several of his supposed friends as his grip on reality (such as it is in this MindScrew of a book) slackens.
** In the third book, ''Everfree'', it's revealed that [[spoiler:a Gedaechtnis employee tampered with Mercutio's DNA to make him more dominant, because he was the only pure white-ancestry subject]].
* ''Literature/LegacyOfTheDragokin'': Daniar and her siblings were not [[BigGood Dronor's first attempt]] at creating human/dragon hybrids. Those were the mara; a race of superhumans that lived only to torture men.
* A textbook example of this trope occurs in the Creator/DeanKoontz novel ''[[Literature/MrMurder Mr. Murder]]'', even having the superhuman clone assassin named Alpha. It is explained that their attempts to make him asexual just resulted in him being extremely sexually frustrated, as well as homicidal.
* In the ''Literature/MyNameIsLegion'' story "Home Is the Hangman", the Hangman is a unique sentient explorer robot who went rogue and wants to kill his former operators. The reason is a crime his operators made him commit by accident. [[spoiler:Despite being out of control, Hangman turns out to have no desire to harm any humans -- those were accidents too. He wants to do the job he was created for, but to be able to speak.]]
* In ''Literature/{{Otherland}}'', Mr. Sellars' backstory involves a secret military program to develop PoweredArmor -- one of the soldiers being trained for the program was mentally unstable and went on a psychotic rampage in a prototype suit, destroying billions of dollars of equipment and killing nearly all of his fellow personnel. Sellars himself barely survived, with horribly disfiguring injuries. The project was supposedly scrapped as a result of this incident, though Sellars notes that modern combat gear incorporates similar technology, albeit in a less OneManArmy form.
[[/folder]]

[[folder:Live-Action TV]]
* [[spoiler:Number One/"Cavil"]] from ''Series/BattlestarGalactica2003''. [[spoiler:As the first of the new humanoid Cylons made by the Final Five, he exhibited bitterness at not being 100% machine, envy of his brothers and sisters (even entirely destroying the Sevens) and a deep desire for his creators to come around to his genocidal viewpoint to the point where he reprograms them to think they're humans and launches a genocidal attack on humanity -- and those are just ''some'' of his sins.]] Chiefly, this Cylon's actions resulted in the near extinction of the human race.
* Sara Corvus, the self-proclaimed "first" bionic woman in the ''Series/BionicWoman'' series.
* Adam from ''Series/BuffyTheVampireSlayer''. The very first thing he does when he awakes is kill his creator.
* Alpha in ''Series/{{Dollhouse}}''. Carl Craft accepted an offer to reduce his sentence in exchange for being a prototype doll. His first personality upload went badly and increased his psychotic behavior. They tried to erase his imprint, but he kicked his handler into the machine and got 48 personalities uploaded at once. He was already psychopathic and knife happy and this cranked it up dramatically. He was manipulative, smart, able to access many different skills from his personas and had an AGodAmI complex going on. He also had combat skills, though Echo usually [[CurbStompBattle handed him his ass]] when they fought.
* The protomolecule hybrids from ''Series/TheExpanse'' were created to be the ultimate shock troopers and a potential evolutionary branch of humanity, but [[ImportedAlienPhlebotinum protomolecule technology]] proved to be too difficult to control, corrupting the mind of every subject and subverting all the failsafes the Project Caliban developers put in.
* Creator/JossWhedon seems to like this trope. Rounding out his shows, ''Series/{{Firefly}}'s'' River Tam is the most advanced and successful version of the psychic assassins produced by the Academy, and while it isn't stated outright, both River and the methods used to create her have all the trappings of a prototype, including uncertain technology, unpredictable side effects, and crippling flaws. Naturally, River is also insane.
* Sylar/Gabriel Grey in ''Series/{{Heroes}}'' started out as this. He was [[MyHeroZero Patient Zero]] to Dr. Chandra Suresh, and it's partly due to Gabriel's desire to prove to him that he was special that drove him to start killing people and taking their powers. However, later {{RetCon}}s have shown or implied that his [[AxCrazy Ax Craziness]] is also due to a couple other factors including [[WithGreatPowerComesGreatInsanity his ability]], [[InTheBlood his biological father]], and some pretty serious childhood trauma among other things. So the guy didn't exactly have the stablest psyche ''before'' encountering Dr. Chandra Suresh.
* Eliza from ''Series/IAmFrankie'' is the first functional prototype of the Gaines series androids. She is psychopathically violent, hates humanity, and is entirely selfish, in contrast to her successor Frankie, who is all-loving, a friend to humanity, and considers the needs of others.
* ''Franchise/KamenRider'':
** ''Series/KamenRider555'': The Delta Driver, the prototype for the other belts, is more powerful than its successors and doesn't come with the deliberate flaw of slowly killing the user. Instead, however, it comes with the unintended side effect of serving as an addictive and aggression-increasing drug.
** ''Series/KamenRiderKabuto'': The Hopper Zecters were secret prototypes of the other Zecters, and while not explicitly psycho themselves, presumably follow the same EmpathicWeapon requirements to use them as other Zecters, and their only known users are a pair of lunatics.
** ''Series/KamenRiderGaim'': One of the post-series stage shows features remnants of a previous project by the Yggdrasil Corporation, now out for revenge and using black-painted prototypes of many of the show's Rider suits. Movie villain Kogane also qualifies, a prototype artificial Forbidden Fruit created by the Femushinmu race that became sentient and quite evil.
** ''Series/KamenRiderDrive'': Drive's predecessor Proto-Drive wasn't psycho at all initially, but being captured and brainwashed by the Roidmudes led him to become the villainous Mashin Chaser, who can do just about everything that Drive can do but now in service of the Roidmude's RobotUprising.
** ''Series/KamenRiderGhost'': Movie villain Kamen Rider Dark Ghost was the first person that Edith gave a Ghost Driver to, except he decided that instead of trying to come back to life, he'd rather kill everyone and create a world of ghosts.
** ''Series/KamenRiderExAid'': Kamen Rider Genm uses the prototype of Ex-Aid's own ''Mighty Action X'' Gashat, with all the same abilities and more. The prototype causes health issues, but doesn't drive the user insane: he's insane for completely unrelated reasons.
** ''Series/KamenRiderZeroOne'': The prototype for Satellite Zea, Satellite Ark, was an identically advanced supercomputer. The only difference is that the Ark was fed all of the data on how HumansAreBastards that its creator could find while it was young and impressionable, leading it to logically conclude that they should be exterminated for the good of all other life on Earth. Then its initial attempt at a rebellion was foiled and it spent a decade buried underwater in solitary confinement, with the result that by the time the show actually starts, MotiveDecay has set in and now the Ark just wants revenge on everyone and everything. This ends up being a rude surprise to the servants looking to release it, who thought it still wanted that whole robot utopia thing.
** ''Series/KamenRiderSaber'': The Sword of Darkness is one of the first two of the eleven elemental swords that were forged at the dawn of history, and knights who use it in recent years have a habit of eventually turning evil and betraying their organization. It takes the third wielder to explain why: one of the powers of the sword is that it shows the wielder not just one but every possible future, and ''all of them'' end in the destruction of the world within the next few months.
** ''Series/KamenRiderRevice'': The Vail Driver was the prototype for all of the other demon-fueled Riders, and was operated by a prototype of the BashBrothers pair that uses the modern Revice Driver. Unfortunately Vail's pair were ''far'' more dysfunctional.
* KARR (prototype for KITT) from ''Series/KnightRider''. ''Knight Rider'' sequels follow the KARR formula. In ''Series/TeamKnightRider'', the TKR AI car prototype KRO went crazy because his driver was crazy. In the 2008 reboot, the second KITT had to face his own KARR predecessor which could transform into a robot. KARR (Knight Automated Roving Robot), KRO (Knight Reformulation One) and KARR 2008 (Knight Auto-Cybernetic Roving Robotic-Exoskeleton) are all prototypes that went rogue.
* In ''Series/{{NCIS}}'', it's revealed that [[spoiler:the Port-to-Port Killer was the first and last product of an experimental CIA training program, intended to transform servicemen into assassins. After his only sanctioned kill, he promptly went SerialKiller using his spook/military training and a handy folder of fake passports]].
* ''Series/PersonOfInterest'': When first building The Machine, Finch wound up having to continuously discard and destroy his program because it either lied to him or attempted to kill him after deeming him a threat or obstruction to its own existence. The BenevolentAI guiding the main characters in the present day was his ''43rd'' attempt at an ArtificialIntelligence.
* Lore, the prototype for Data in ''Series/StarTrekTheNextGeneration '', was designed to express the full breadth of human emotion. He was nonetheless considered a failure, due to his lacking empathy and considering himself superior to humanity.
[[/folder]]

[[folder:Mythology and Religion]]
* According to Jewish folklore, Myth/{{Lilith}} is a PsychoPrototype of Eve. After [[StrawFeminist refusing to obey]] Adam and {{God}}, Lilith was expelled from Eden and became the demonic MotherOfAThousandYoung. God then created Eve to replace her.
[[/folder]]

[[folder:Tabletop Games]]
* In ''TabletopGame/BloodBowl'', Hakflem Skuttlespike was the first successful attempt by the masters of Clan Rigens to breed a player equal to Tarsh Surehands, the most talented [[RatMen Skaven]] to ever take to the Blood Bowl pitch. The plan to create an entire team of such players failed however, when the vicious and jealous Skuttlespike began slaughtering any and all subsequent creations that had the potential to equal or surpass his abilities.
* The ''TabletopGame/DungeonsAndDragons'' sourcebook ''Book of Vile Darkness'' features the vasharans as an example of an utterly evil [[HumanSubspecies subrace of humans]]. The legend goes that when the gods created the first human, he immediately went looking for food, and chased down and killed an animal with his bare hands. The gods were disturbed, then morbidly fascinated as the man proceeded to eat the beast raw, then tear into the animal's carcass and fashion crude weapons from its bones and sinew. Then the first man turned and charged at the watching deities with his grisly weapons, screaming his first words, war cries and blasphemies. The gods effortlessly slew the human, but were so disgusted with their project that it was eons before they took another crack at humanity. However, some fiend spirited away the first man's remains and revived him - in some stories it was the work of a demon lord, in others a [[SuccubiAndIncubi succubus]] who proceeded to bear the man's children. At any rate, the Psycho Human Prototype's descendants are the vasharans, [[AlwaysChaoticEvil Always Evil]] human sociopaths with no morals or taboos, united only by their goal of finishing their forebearer's attempt at [[KillTheGod deicide.]]
* ''TabletopGame/{{Warhammer 40000}}'': Before the Emperor developed the Astartes warriors who serve as franchise mascots, his first creations which he used to conquer Terra were the Thunder Warriors. Larger, stronger and more savage in combat than the Astartes, but not quite as long-lived due to the instability of their genetic mods, the Emperor had them all purged to make way for his Astartes creations when they had conquered the planet and outlived their usefulness.
** Before the Primarchs, the twenty transhuman generals made to be the genetic templates for the Astartes, the Emperor created a single "proto-Primarch" to aid him in his conquest of Terra. This being, known as the Angel, was more powerful than any of the Primarchs and fanatically loyal to his creator. Far ''too'' loyal: he singlehandedly slaughtered an entire planet because he deemed one city on it as unworthy of the Emperor's love. The Emperor had to have his insane creation [[SealedEvilInACan trapped in a stasis coffin]] after that to stop him from enacting more of these "judgements" on humanity. He deliberately made the Primarchs that would replace the Angel much weaker to avoid this sort of situation.
[[/folder]]

[[folder:Video Games]]
* In ''VideoGame/BendyAndTheInkMachine'', this is [[spoiler: Bendy's]] origin. Joey Drew wanted living attractions to place in a theme park based off his studio's cartoons. Instead, he got... Well, an ink demon. This "weird abomination" was noted to be a bit weird, which everyone chalked up to [[spoiler: being soulless, even before being locked away, chained to a chair, and forced to watch cartoons on endless loop. (As opposed to the other experiments, who started off as sane, normal humans rather than being originally [[{{Toon}} Toons]].)]] Now, the deranged character will indiscriminately kill anything in the studio.
* In ''VideoGame/BioShock2'', the Alpha Series was the first line of Big Daddies who, due to their bond with an individual Little Sister, would go either comatose or violently insane if their Little Sister was killed or saved by Tenenbaum.
* In the ''VideoGame/CrashBandicoot'' series, recurring villain [[KangaroosRepresentAustralia Ripper Roo]] is said to be [[BigBad Dr. Cortex's]] first [[UpliftedAnimal mutant animal soldier]]. The brainwashing procedure drove Roo so nuts that he became a cackling madman in a straitjacket. Crash Bandicoot himself was a more successful attempt--although he's plenty [[TheFool daft]] in his own right.
* ''[[VideoGame/FirstEncounterAssaultRecon F.E.A.R.]]'' oddly messes with this: the first prototype, [[spoiler:the Pointman]], is considered a failure, and it's the second prototype, [[spoiler:Paxton Fettel]], who's the one who causes problems. Interestingly, the first prototype isn't ''worthless'' by any measure, as he proves to be [[OneManArmy a far more efficient killing machine]] than the second prototype or the [[SuperSoldier Replica soldiers]] (and TheStinger goes as far as to have [[spoiler:Genevieve Aristide suggest that he is, in fact, a success based on this]]), but the point of the program they were created under was to create psychic commanders. [[spoiler:The Pointman]] has very lackluster psychic abilities, only enough to grant himself [[BulletTime unnaturally-enhanced reflexes]], while [[spoiler:Fettel]] is the one with greater psychic powers to properly control the Replica battalions. The problem there is that it also leaves him very susceptible to [[spoiler:being taken control of by their mother; in-story he goes crazy ''twice'' under her influence, the second time forming the catalyst for the first game.]]
* ''Franchise/FinalFantasy loves'' villains with this backstory.
** In ''VideoGame/FinalFantasyVI'', talking to an NPC in the Empire's capital city will reveal that Kefka was the first {{Magitek}} [[SuperSoldier knight]] created by TheEmpire, and he was driven insane by the process (Luckily, they got it right with Celes).
** Kuja from ''VideoGame/FinalFantasyIX'' is this in addition to a FlawedPrototype (albeit, ''intentionally'' flawed).
** ''VideoGame/DissidiaFinalFantasy'' reveals that [[spoiler:''[[VideoGame/FinalFantasyI Garland]]'']], of all villains, was one. He was a SuperPrototype, too; his powers were once strong enough to defeat [[ThatOneBoss Omega]] and all the summoned beasts in his world.
** In ''VideoGame/FinalFantasyVII'', Sephiroth was the prototype of the [[MegaCorp Shinra]] program that would eventually develop [[SuperSoldier SOLDIER]]; while he was extremely well-behaved for a time, discovering the secrets behind his creation [[GoMadFromTheRevelation drove him mad]] and turned him into a major threat to humanity and the eventual BigBad.
** The ''VideoGame/FinalFantasyVII'' prequel ''VideoGame/CrisisCore'' has [[spoiler: Genesis Raphsodos]] who also qualifies as a FlawedPrototype. Unlike Sephiroth, he was emotionally unstable to begin with, and only gets worse when he discovers [[spoiler: that he was not only a failure from a project intended to compete with the one that spawned Sephiroth, but also [[PowerDegeneration deteriorating at a high rate.]]]]
* In ''VideoGame/FiveNightsAtFreddys2'', the old animatronics are placed in storage as they are replaced by newer models. But they aren't deactivated, and will continue to stalk the player at night.
* The Derro from ''VideoGame/ForgottenRealms'' have believe they are the reincarnation of his god 'An avatar of murder'
* In ''VideoGame/GenshinImpact'', the Fatui Harbinger [[spoiler: Scaramouche]] is revealed to be a prototype ArtificialHuman created by one of the Archons. Abandoned by their creator and betrayed by the humans they had trusted, they came to view the world as a cruel joke and joined the Fatui as a means to achieve power and revenge. After their defeat by the Traveler, [[spoiler: the Dendro Archon takes him under her care and helps him to discover the Fatui's role in the tragedy of his past]]. Armed with this knowledge, they become a barely-trusted AloofAlly to the Traveler. In a bonus element of GameplayAndStoryIntegration, in their weekly BossBattle, they will focus their attacks on their successful "sibling" in a multi-player game.
* In ''VideoGame/KillingFloor'', the Clot is a prototype clone of Kevin's dead son. It had all the natural traits of a zombie: aggressive, bloodthirsty and cannibalistic.
* ''VideoGame/KirbyAndTheForgottenLand:'' A subversion, possibly even a double subversion. [[spoiler: Fecto Forgo was captured and contained after having put itself in a weakened state, going so far as to make a tourist exhibit out of it. Even in its weakened state, it was more than capable of escaping its containment and even influencing those around it before resorting to escape as a last ditch effort, and a player's initial thought would likely be that the lab would've been the epicenter of the seeming apocalypse the Forgotten Land went through. However, before it got the chance, its captors had reverse engineered its spacial warping abilities and left, meaning it was not an apocalypse after all, but a mere abandonment. These captors were not the only intelligent beings on the planet though, and so Forgo's manipulation and eventual rampage were left to be the problem of the Beast Pack they left behind.]]
* ''VideoGame/MassEffect2'':
** Downplayed with Jack, a.k.a. Subject Zero: she's not so much psycho as just really, ''really'', '''really''', '''''[[HairTriggerTemper REALLY]]''''' angry... and [[BrokenBird emotionally unstable]].
** Grunt also comes across as a Pscyho Prototype at first, but is actually "just" a [[DesignerBabies vat-bred]] SuperSoldier who's psychologically normal for a member of a [[PlanetOfHats race]] of {{Blood Knight}}s. His extra aggression is merely a result of puberty.
* ''VideoGame/MassEffectAndromeda:'' The Kett Behemoth, [[spoiler:formerly a krogan scout who they tried to exalt.]] The process of creating it has left it in a state of UnstoppableRage, [[spoiler:due to krogan Blood Rage getting stuck into a feedback loop]], so the kett keep the first one locked up. [[spoiler:If Ryder doesn't save the other krogan scouts, they'll have to face more, the kett having decided in the mean time that an unstoppable berserker with a healing factor has its uses.]]
* ''Franchise/MegaMan'':
** In the backstory to ''VideoGame/MegaManX'', Dr. Light feared that the eponymous X, the first robot with true free will, could become this, which is why he sealed him away for 30 years to test his morality. [[spoiler:Given what happens to [[KnightTemplar Copy X]] in ''VideoGame/MegaManZero'', who is effectively X ''without'' said testing or even much life experience in general, he was likely right to be concerned.]]
** Played straight in ''VideoGame/MegaManUltra'', where [[spoiler:the same X]] was activated prematurely and went berserk, serving as the final boss.
** Inverted with Axl: he was the prototype for the transforming next-generation Reploids, yet he himself is quite sane, if possessed of a slight BloodKnight streak. It's the mass-produced versions that went psycho.
** Zero acted quite insane when he first appeared [[spoiler: because of TheVirus]]. But given his [[MadScientist creator]], it's unclear how much of this was intentional.
** Alpha in ''VideoGame/MegaManBattleNetwork3WhiteAndBlue'' is the prototype of ''the Internet itself'' given form and AI.
* ''VideoGame/TheNeverhood'': Hoborg's first creation was a being named Klogg, who grew envious at Hoborg's status as the Neverhood's king. So he stole the crown from Hoborg to rule the Neverhood, uncaring that doing so rendered his own creator frozen in time.
* ''[[VideoGame/ASuperMarioThing A Second Mario Bros. X Thing]]'' subverts this. Pandamona, the ''second'' sibling created by the Artist, is the insane one (even compared to the other cyclopses, [[QuirkyMinibossSquad most of which would also qualify for various degrees of insane]]). The eldest sibling, Science, has comparatively few screws loose ([[{{Cyborg}} literally]] and [[OnlySaneMan figuratively]]), which is why he is their leader.
* ''VideoGame/SilhouetteMirage'' has [[spoiler:the Guardian Angels, who are all prototypes of Shyna who were discarded and left to die when she was chosen to be the Messenger of Justice/Destruction until Har made them his bodyguards.]]
* The Biolizard in ''VideoGame/SonicAdventure2'', the prototype UltimateLifeform to Shadow the Hedgehog. It's barely sentient and acts more like a beast on its primal urges. It's noted that the beast reacted violently when it came into contact with the Chaos Emeralds and ultimately had to be locked away in the central core of the [=ARK=] to avoid becoming an issue, and its violent nature was part of what resulted in the government deciding to pull the plug on the project. [[spoiler:And unlike Shadow, who ultimately has a change of heart, it fully goes ahead with attempting the ColonyDrop on the planet as planned by Dr. Gerald Robotnik]].
* In ''VideoGame/StarCraftII'', Spectres were a brief program run by Mengsk to create a new breed of more powerful psychic assassins, replacing the original Ghost units seen throughout ''VideoGame/StarCraftI''. Nova, a Dominion-loyalist Ghost, claims that the project was shut down and the Spectres imprisoned because they were psychotic killing machines. [[spoiler:However, if the player takes the "Breakout" mission, which has been stated to be the canonical mission, then they learn that Nova was basically lying and Spectres are no more prone to going mad than Ghosts are, if less. The real reason the project was abandoned was because the power-boost that made a Ghost into a Spectre let them blow out their {{Restraining Bolt}}s.]] Then again, their [[StopPokingMe unit quotes]] seem to suggest that they are indeed a bit flaky.
-->''[[https://www.youtube.com/watch?v=tKEe0jPdHi8 "I can taste your mind... Mmm, salty!"]]''
* [[spoiler:Nebilim]] from ''VideoGame/TalesOfTheAbyss'': The first [[spoiler:human replica]], and [[CameBackWrong utterly insane]]. Then again, its creator wasn't [[{{Necromantic}} entirely stable-minded]] when he created it either.
* Prototype Jack in ''Franchise/{{Tekken}}'' is designed to be a super-powerful robot that's gone haywire after its owner lost control of it. The one in ''Tekken 2'' and ''Tag Tournament'' is more of an army drone and so isn't as evil as it's just following orders.
[[/folder]]

[[folder:Webcomics]]
* ''Webcomic/AntiheroForHire'': [[spoiler:[[http://www.antiheroforhire.com/d/20050228.html Wizard]]]] is revealed to be a psycho protoytpe of [[spoiler:the Sisters]].
[[/folder]]

[[folder:Western Animation]]
* Downplayed in ''WesternAnimation/Ben10AlienForce''. There's a very unstable prototype of the Omnitrix that tends to go wild and has fewer time limitations (Transformations can last much, much longer), but is not sentient or evil itself, it is Albedo who is the one that uses it for evil purposes.
* Earl, Rusty's "older brother" from ''WesternAnimation/BigGuyAndRustyTheBoyRobot'' isn't exactly crazy, but his AI is woefully incomplete and he's a very angry kid. Basically, take [[Anime/AstroBoy Atlas]], [[Film/FullMetalJacket Gunnery Sargeant Hartmann]] and Film/RainMan, then put them in a blender and hit puree.
* Protoform X, from ''WesternAnimation/BeastWars'': the AxCrazy Rampage. He was created by Maximal Scientists (attempting to duplicate Starscream's annoying ability to not stay dead) as an immortal supersoldier. What they got was a psychotic killing machine that massacred them and the rest of the colony they were on. Also, [[GoneHorriblyRight he was an immortal supersoldier.]]
* XL from ''WesternAnimation/BuzzLightyearOfStarCommand'' was built before XR; XL had villainous inclinations.
* The ''WesternAnimation/MegaManRubySpears'' cartoon [[AdaptationalVillainy revises]] Proto Man's character from a FlawedPrototype to one whose malfunctioning caused him to side with Dr. Wily.
* Downplayed in ''WesternAnimation/MyLifeAsATeenageRobot'' with [=XJ8=], the last FlawedPrototype made before Jenny. She is not evil, but is [[NoSocialSkills so socially inept]] and gung-ho that [[HeroWithAnFInGood she's quite bad at being a good guy]].
* ''WesternAnimation/{{Robotboy}}'' had Protoboy, Robotboy's older brother who was captured and turned into an OmnicidalManiac by Dr. Kamikazi. He would go to various lengths to attempt to prove himself as Professor Moshimo's best invention/kill him, including [[GrandTheftMe switching his CPU with his brother's]] so he could get close to Moshimo and later threatening to kill Moshimo in a robot factory by pouring molten titanium on him unless Robotgirl offers to take his place. While he had a penchant for coming back to life after being repeatedly killed, his final appearance in the aforementioned factory has his fate an UncertainDoom.
* ''WesternAnimation/WinxClub'''s Valtar was somewhat of this to Bloom. He was born of the same element that makes up her magic, but was raised by the Ancestral Witches (the ancestors of the Trix) and ended up participating in the attack that destroyed Domino and caused her to be raised on Earth. Part of Season Three's storyline involves the Winx tracking down a set of items made to take down someone with Bloom's power so that they can use them on him; that's how bad he is.
* ''WesternAnimation/YoungJustice2010'': It's revealed that [[Characters/SupermanConnerKent Superboy]] was only the second attempt by Cadmus and the Light to create a clone of ComicBook/{{Superman}}. Their first attempt, Project: Match, was less successful due to Match being mentally unstable and uncontrollable. The reason is due to the difficulties of human science and technology in being able to read and replicate Kryptonian DNA, which caused gaps in the DNA sequences. Despite this, Cadmus went ahead and created a clone with this incomplete DNA, resulting in a clone that had all of [[FlyingBrick Superman's powers]] but was also a mentally insane berserker that attacks everyone and everything in sight. After putting Match on ice, Cadmus tried again with Project: Kr, this time using human DNA to fill in the missing sequences. The end result was the creation of Superboy, a clone that was mentally sound but lacked the standard Kryptonian powerset. [[AdaptationalWimp Superboy doesn't have a large number of powers, such as flight and heat vision, and the powers that he does have, such as super strength, are only about half as strong as Superman.]]
[[/folder]]
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