A Psychedelic Comedy Bromance is a {{Duo Trope|s}} that results from an OddCouple or other ComedicDuo acting as the protagonists in a world where they are likely to come across HighWeirdness, CosmicHorror, or other trippy or terrifying happenings. This could be a HighFantasy setting, but it is often just a version of the ordinary world where supernatural, highly improbable, or otherwise wild things just happen to happen. The duo contends with the weirdness as best they know how. They may both be seriously endangered when reality goes on the fritz, or the StraightMan may not be able to cope with the oddities and lets the LovableRogue deal with it, though they may be an AdventureDuo who are well-equipped to handle the situation.

Notable examples:



[[folder: Literature]]
* ''Literature/TheHitchHikersGuideToTheGalaxy'' has this dynamic between Arthur and Ford for much of the series.
* ''JohnDiesAtTheEnd''

* ''Series/TheMightyBoosh''.

[[folder: Western Animation]]
* WesternAnimation/AdventureTime
* WesternAnimation/RegularShow
* WebAnimation/DickFigures