[[quoteright:320:[[WorldOfWarcraft http://static.tvtropes.org/pmwiki/pub/images/Rogue1_9736.gif]]]]
[[caption-width-right:320:6.5% increase in total damage done, what do you mean it's not deadly?]]

->''"[[TheEvilPrince Tavius]] was right about one thing. I do have a fair knowledge of poisons."''
-->-- '''Otho''', ''Series/StargateAtlantis'', after [[HoistByHisOwnPetard getting nicked]] [[LastWords with his own knife]].

[[ExactlyWhatItSaysOnTheTin When a weapon is poisoned]] for added lethality. The weapon is frequently a dagger, but often an arrow, dart, or even a sword. Expect from such a weapon to ooze a [[TechnicolorToxin purple or green]] and possibly [[PoisonIsCorrosive stone-melting]] liquid. The poison is likely to either act instantly, or be [[AlmostDeadGuy timed to]] the FinalSpeech.

Poisoned weapons are typically [[PoisonIsEvil used by villains]] (and HungryJungle natives, who get a free pass), since they allow an easy victory or a spiteful revenge despite losing, especially in a duel. TheHero is usually too {{honor|BeforeReason}}able or [[LawfulStupid stupid]] to use it himself. Heroes down the SlidingScaleOfIdealismVsCynicism and {{Combat Pragmatist}}s sometimes use poison. A literary device as old as time is to have a confrontation involving a poisoned weapon which the audience knows is poisoned, but the [[DramaticIrony characters involved do not]].

It should be noted that the poison being ''fatal'' isn't always the case. Often times, the poison will be nonlethal and merely intended to weaken, paralyze, or disorient the target instead. Reasons why vary from wanting to capture them alive, to avoid accidentally killing oneself, to wanting to actually kill them with their own hand but knowing they only stand a chance against them if they're weakened. Its almost never for safety's sake, where the villain doesn't want to risk killing themselves with an accidental nick of their own blade outside of combat. If the poison is actually lethal, it normally depends on who is hit with it whether or not the poison will actually kill them. If a hero is infected, the poison will normally be slow acting enough to permit a FindTheCure by his allies, but not always. If it's the villain, they're more likely to die.

See also MasterPoisoner.
----
!!Examples:

[[foldercontrol]]

[[folder: Anime ]]
* In ''Anime/{{Noir}}'', Shaoli delivers deadly poison with a mere scratch of her fingernails.
* In ''Anime/BloodPlus'', Saya's sword has a little groove in it for her blood, which is fatal to most chiropterans.
* Quite common in ''Manga/{{Naruto}}'': Sasori tips every weapon he has with poison (which is a lot of weapons), Shizune and one of Kankuro's puppets have poison needles, the Demon Brothers that Team 7 run into on the way to the Land of Waves used poison claws, Sakura once poisoned a kunai (and that she apparently learned to make it from Shizune), and [[PoisonousPerson Hanzo]] put some of his poison on his kusarigama.
* ''Manga/{{Bleach}}''
** LittleMissBadass Loly's zanpakutou is a dagger that releases poison.
** [[SociopathicHero Evil bastard]] Mayuri Kurotsuchi's ''zanpakutou'' also poisons its target upon wounding them; befitting his extraordinarily sadistic personality, it paralyzes the victim's limbs enough to prevent movement without affecting their ability to feel pain.
** One Bankai is revealed to be hiding the ability to leave a piece of the blade behind in an opponent's body whereupon it breaks down into a poison that destroys the enemy's cellular structure. [[spoiler:The Bankai belongs to Gin and he kept its true power secret in an attempt to ambush and kill Aizen.]]
* In ''Manga/OnePiece'', Crocodile's trump card is a poisoned hook-hand.
** Brook and his entire crew were killed by pirates with poisoned weapons.
** In the same fashion, Don Krieg's most powerful weapon is a cannon ball filled with (oddly) white coloured poison Gas.
** Wanze from the [=CP7=] wields a huge poisonous kitchen knife as his last resort.
** Thanks to the [[PoisonousPerson Doku-Doku Fruit (Poison-Poison Fruit)]], Impel Down's Chief Warden Magellen can use his '''entire body''' as a poisoned weapon.
** In a non canon example, Wapol's brother Musshul ate the Noko Noko fruit (stands for kinoko, mushroom) and can manipulate poisonous spores. This includes bullets, a [[ThisIsADrill drill like fungus on his arm]] and poison clouds.
** Hyouzou from the New Fishman Pirates is a Blue-Ringed Octopus Merman and can coat his swords with his venom.
* In ''Anime/DigimonAdventure'', [=DemiDevimon=] tries to kill Sora with a poison dart, but Biyomon TakesTheBullet for her. Thankfully for her, while the poison is lethal to humans, it only makes Digimon severely ill for a time. Which is rather unfortunate because [[BigBad Myotismon]] shows up directly after that...
* [[PoisonousPerson Coco]] from ''{{Toriko}}'' can [[SpontaneousWeaponCreation create]] poisoned weapons by combining the poison in his body with the clotting agents from his blood.
* In ''Manga/OmamoriHimari'', Kuesu pulls a gun on Himari and shoots at her. When Himari is grazed, Kuesu reveals the bullets have been coated with a potion that strips an ayakashi of their human mind and fills them with murderous bloodlust, the idea being that win or lose, Yuuto would reject Himari for turning into what he hates, a killer. Himari manages to resist the potion and escape.
* In ''Manga/MyBrideIsAMermaid'', Maki may be six inches tall and wield a tiny sword, but it's coated with puffer fish toxin.
* In ''LightNovel/TheFamiliarOfZero'', Jeanette's dagger is coated with a paralyzing potion.
[[/folder]]

[[folder: Comics ]]
* MasterPoisoner and PsychoForHire Cheshire loves these. It's generally dangerous to let her so much as scratch you.
-->'''Cheshire''': Hand me one of your bullets. I have something agonizing to dip it in.
* In ''Dhampyr'', Harlan Draka and his friends often dip their weapons and bullets in Harlan's blood, since he is a dhampyr and his blood is [[PoisonIsCorrosive dangerous]] to [[BodyHorror vampires]].
[[/folder]]

[[folder: Fanfiction ]]
* In ''FanFic/AeonEntelechyEvangelion'' a human working for the Migou used tiny carbon-fibre syringes hidden in her knuckles to assassinate the Marshal.
* In ''FanFic/WinterWar'', [[spoiler: Soi Fong and Ukitake finally manage to kill the Barragan Fragment by getting its [[BloodyMurder corrosive blood]] on their swords. Unfortunately for them, the blood is also eating through their {{Empathic Weapon}}s as they fight...]]
* In ''FanFic/TheFledglingYear'', this is [[spoiler:Gyneth’s]] apparent chosen method for her plan to [[HoneyTrap seduce]] and {{assassin}}ate Prince Cor.

[[/folder]]

[[folder: Film ]]
* ''Franchise/IndianaJones'': Poisoned blowdarts are featured twice.
** By Hovitos in ''Film/RaidersOfTheLostArk''
** ''Film/IndianaJonesAndTheKingdomOfTheCrystalSkull''
* The Na'vi of ''Film/{{Avatar}}'' dip their arrows in a toxin that will stop a human's heart in a minute. That doesn't really matter, though, because the arrows are the size of broomsticks and the Na'vi are crack shots.
* ''OurManFlint''. Gila uses a poisoned dart propelled by a harp to try to assassinate Flint, and Flint uses a curare-tipped dart to take out a fly.
* ''Film/HudsonHawk''. Almond Joy uses a blowgun with curare-tipped darts against the title character and Tommy Five-Tone.
* In ''Film/FromRussiaWithLove'' Rosa Klebb has a poisoned dagger in the toe of her shoe. At the end, she has a kicking fight with James Bond who pushes her against the wall with a chair until Tatiana Romanova shoots her. (Compare with the novel)
* ''ThatManFromRio'' opens with a museum robbery, where the crook kills a guard with a poison dart gun. It initially looks like heart failure to the police, but the museum head notes the poison is a common weapon of the vanished Mesoamerican culture that made the stolen artifact.
* In ''Franchise/PiratesOfTheCaribbean: On Stranger Tides'', [[spoiler: Barbossa]] poisons his sword in order to insure even more suffering when he attempts [[spoiler: (and succeeds) to kill Blackbeard.]]
* In ''Film/TheWolverine'', some moronic hunters attack a bear with illegal poisoned arrows. The bear kills several of them and escapes, but is left in agony. After Wolverine gives it a MercyKill, he angrily confronts the remaining hunters and stabs one of them with one of the arrows. Later, Wolverine is attacked by several ninjas with poisoned arrows.
* In ''Film/TheHobbit'', Kíli gets shot with a Mordor arrow when opening the Mirkwood river gates to let the Dwarves in barrels through. Its effects take their toll on him later, putting him in increasingly agonizing pain.
* In ''WesternAnimation/{{Rio 2}}'', Nigel plans to shoot Blu with a porcupine quill tipped with poison-dart frog toxin. [[spoiler:It turns out the frog from which he got the toxin is not actually poisonous, however.]]
* In ''Film/{{Transcendence}}'', the assassin that targets Will uses bullets laced with polonium. If the bullet itself doesn't kill him, radioactive material flowing through his veins will finish the job.
* In the ending to ''Film/AMillionWaysToDieInTheWest'', [[spoiler:Albert laced his bullets with rattlesnake venom. He manages to graze [[BigBad Clinch's]] arm before getting disarmed, then stalled for time until the venom could take effect.]]
[[/folder]]

[[folder: Literature ]]
* ''Literature/{{Dune}}'' loves this one:
** The gom jabbar, a poisoned needle used by Bene Gesserit Proctors in their death-alternative test of human awareness, is a "specific poison needle tipped with meta-cyanide". It's also the weapon used by Alia to kill the Baron Harkonnen.
** The first book has Paul facing Feyd Rautha at the end duel. Feyd has a poisoned spring needle in his belt. They both also have poisoned blades, Feyd's with a soporific and Paul's with acid.
** Crysknives often have a groove in them where poison can be applied.
** When fighting gladiators, Feyd-Rautha Harkonnen was allowed to use a short knife with a poisoned blade. During his hundredth bout, he secretly put the poison on his long knife instead, which allowed him to win the match.
* ''Literature/{{Redwall}}'': Employed by villains. Cluny the Scourge has a poisoned barb on the end of his tail, which kills the Abbot slowly enough for him to deliver his FinalSpeech, and the minor character Farran the Poisoner possesses an instant-death poisoned dagger.
* ''Literature/TheObsidianTrilogy'': The Goblins have deadly poison on their claws and teeth (the Shadowed Elves often use them on weapons). Only the timely intervention of a unicorn can save someone from even a slight or incidental dose.
* In ''Literature/TheLordOfTheRings'', the Witch-King stabs Frodo with a Morgul-blade. If Elrond hadn't cured him, the poison of the blade would have turned him into a wraith. It's also mentioned in the books that orcs sometimes put poison on their blades.
* In one of the ''TheStainlessSteelRat'' stories, a character gets into a fight with an assassin, and the knife barely touches the assassin and he dies, it turns out not only did he have a ''very'' nasty knife but the knife was coated with a neurotoxin that would kill anyone on skin contact.
* ''Literature/ASongOfIceAndFire'': Oberyn Martell (aka The Red Viper) is infamous for using poisoned weapons, and it allows him to deliver a quasi-fatal wound to the [[TheBrute Brutish]] Gregor Clegane.
** The Crannogmen are also infamous for fighting with poisoned arrows and utilizing the swamps that surround their lands when they fight. Their foes refer to them as bog devils because of this.
* ''Man Plus'', a science fiction novel by Creator/FrederikPohl, has the U.S. Secret Service require women meeting the president to soak their hands in a solution first, in case their fingernails have a biochemical poison on them.
* In ''Literature/TheWheelOfTime'', a form of dueling is mentioned as having existed shortly before [[CataclysmBackstory the collapse of the Age of Legends]] which involved DualWielding daggers laced with a slow-acting poison. Most duels ended with both participants dying.
* ''Literature/SherlockHolmes'': The villain of ''The Adventure of the Dying Detective'' is a doctor who has killed his nephew by surreptitiously injecting him with a deadly illness. He later on tries to do Holmes in the same way by sending him a package with secret spring-loaded, virus-tipped needles, but Holmes is able to see through his scheme. (Having a lot of enemies tends to make the detective overly cautious of the mail he receives.) Holmes pretends to be infected, and he soon manages to lure the evil doctor over to his apartment and trick him into a confession in front of witnesses.
* When the anti-hero protagonist of ''Literature/AlteredCarbon'' goes to the armorer, among the weapons he buys is a poison-coated knife.
* ''[[{{Belgariad}} Mallorean]]'': [[MasterPoisoner Sadi]], one of the heroic party members carries a variety of poisons, and his major weapon in battle is a poisoned dagger. When [[TheMentor Belgarath]] asks the group to minimize casualties during a fight with {{Mooks}}, he's responsible for two of the three deaths at its close - "It's a little hard to unpoison a knife." (The third was [[CombatPragmatist Silk]] taking out an ambusher.)
* ''Literature/{{The Sword of Shannara|Trilogy}}'': Menion Leah, a heroic protagonist, poisons some arrows when the opportunity arises, just in case. He uses them in the very next scene to try and kill a dragon.
* A prequel to ''Literature/DeptfordMice'' series has enemies who wear golden claws with an impossibly nasty poison that causes you to pretty much dissolve into goo. When one character finds an unconscious one of them, HoistByHisOwnPetard is subverted by WhatAnIdiot when the guy decides to put on the claw and kill him with it, but accidentally scratches himself. He then runs away from the incurable poison already in his veins, and dies very quickly as opposed to using his remaining time to say, ''kill the one he poisoned himself getting ready to kill''.
* In some versions of ''{{Tristan and Isolde}}'', Tristan is poisoned by the Irish knight Morholt's spear (but wins the duel), and [[MosesInTheBullrushes sent on a craft without rows or sail]] as a last-ditch effort. He lands in Ireland, where Morholt's niece Isolde cures him, not knowing ''he'' was Morholt's killer.
* Hercules had arrows poisoned with hydra blood. Creator/{{Sophocles}} is the first author to mention this, making this one OlderThanFeudalism. Similarly, a poisoned arrow was used to finally kill the otherwise InvincibleHero Achilles towards the end of the Trojan War.
* Valeri Petrofsky of ''The Fourth Protocol'' by FrederickForsyth carried a handgun that fired hollow-point bullets ''[[AbnormalAmmo filled with cyanide]].''
* ''Literature/TheCabinetOfCuriosities'' reveals that the [[DiscOneFinalBoss thought to be]] BigBad was [[spoiler: poisoning weapons, clothing, and other objects in an effort to find an effective means of destroying humanity, research he stopped only because he felt the creation of Hydrogen Bomb made him think the rest of humanity was perfectly capable of destroying itself on its own]].
* ''This Immortal'' by RogerZelazny: assassin Hasan (who has been forcibly disarmed) is forced to fight [[ImplacableMan the Dead Man]] and spends the time filing his nails. To really sharp points. His bullets (which weren't taken away) had meta-cyanide on them. He scratched the Dead Man at the start of the fight, and stalled until it dropped. Then he got the leader too.
* ''Literature/TheSaint'': The Saint himself discovered a poison-dart launcher built into a doorbell once. He avoided getting shot, kept the dart, and later used it in a booby-trapped parcel to [[HoistByHisOwnPetard prick the finger of the villain]].
* ''[[MrsMurphyMysteries The Tail of the Tip Off]]'': A rather ingenious example is found in Rita Mae Brown's novel. When H. H. Donaldson drops dead after going to a basketball game, an autopsy shows he was poisoned through an injection in the neck, but the poison would have had to have been administered during the game for it to kill him when it did. No one saw anything despite the bleachers being packed, and Donaldson didn't react in any way as he would have had someone jabbed him in the neck with a needle. [[spoiler: It turns out the killer froze the poison into an ice dart, and was able to kill Donaldson by shooting it our of a noise maker into his neck. No weapon was found because the ice melted, releasing the poison.]]
* In Creator/EdgarRiceBurroughs's original ''Literature/{{Tarzan}}'' books, Tarzan uses poison arrows that he steals from the natives, at least until he scares them into leaving a bundle out with some food every so often as 'tribute' to the forest spirit they think they've angered.
* In the ''ConanTheBarbarian'' story ''Literature/BlackColossus'', Shevatas poisoned his blade to deal with the snake.
* In ''Literature/FromRussiaWithLove'', Rosa Klebb had a poisoned dagger at the toe of her shoe. She nicks James Bond with it and he passes out from the poison in seconds. The novel ends at that point. (Compare with the film)
* In ''Literature/MemorySorrowAndThorn'', [[MagicalNativeAmerican Binabik]] carries a hollow walking stick, a small roll of poisoned needles, and a bundle of loose wool. When combined, these make a blowgun that shoots poison darts, allowing the diminutive [[OurTrollsAreDifferent troll]] to pack a lethal stealth attack.
[[/folder]]

[[folder: Live-Action Television]]
* In ''Series/XenaWarriorPrincess'', Gabrielle gets hit by a poisoned arrow. Xena has to look after her and find the antidote in time whilst fighting off an entire army.
* One episode of ''Series/GetSmart'' had some YellowPeril villain with long, poison coated fingernails. It probably best summarized that show, too, with him getting defeated because Agent 99 randomly had a bottled mosquito in her purse, which she used to get him to accidentally scratch himself upon swatting it.
* In ''Series/StargateAtlantis'' episode "The Tower", Sheppard ends up with the EvilChancellor trying to kill him in the climax. When Sheppard disarms him, Otho is cut with his own poisoned dagger and dies in moments, after providing the quote up above.
* ''Series/BuffyTheVampireSlayer'': Faith poisons Angel by shooting him with a poisoned arrow.
* [[OurWerewolvesAreDifferent Monroe]] uses an elephant gun with bullets coated in a special poison to take a [[OurOgresAreHungrier siegbarste]] in ''Series/{{Grimm}}''.
* PlayedForLaughs in ''Series/TheHeroYoshihikoAndTheDevilKingsCastle'' where a random {{Mook}} [[LickingTheBlade licks]] ''[[http://24.media.tumblr.com/929fce082e339882952e22c8f63fe05a/tumblr_mi0h9pR6cl1r1hdaho1_1280.jpg his very own poisoned knife]]''. TooDumbToLive indeed.
* It's mentioned in ''Series/BabylonFive'' that the [[TheReptilians Drazi]] often poison their blade tips.
** Centauri actually have jeweled hyperdermic needles. In other words they treasure poisons the way humans treasure swords.
* In ''Series/{{Charmed}}'', darklighters are the only beings capable of killing whitelighters. They use arrows coated with a substance that is toxic only to whitelighters.
* In ''Series/{{Sliders}}'', Remy is shot by a Kromagg particle weapon. The wound isn't fatal, but the radiation poisoning that come with being shot would have been had he not been healed by a friendly Kromagg half-breed.
* ''Series/StarTrekDeepSpaceNine'' has a futuristic variant. Dominion weapons carry an anti-coagulant with every shot. Anyone they don't kill bleeds to death unless they can get off the battlefield and to a doctor.
[[/folder]]

[[folder: Newspaper Comics ]]
* The Bandar Pygmy tribe, allies of ComicStrip/ThePhantom, are infamous for their envenomed arrows. A [[FantasticSlur less polite term for them]], used by their neighbours, is The Poison People.
[[/folder]]

[[folder: Tabletop Games ]]
* The [[OurElvesArebetter Dark Elves]] in ''Warlords Battlecry'' will use poisoned weapons.
* Poisoned weapons are a game mechanic in ''TabletopGame/{{Warhammer}}'' and ''TabletopGame/{{Warhammer 40000}}''. The latter has guns which fire ninja stars coated in a poison so horrible it ''makes the target's blood explode''. Generally used by the [[BlackAndGreyMorality even more evil races]], though in ''Warhammer'' they're a specialty of the close-as-you-get-to-good Lizardmen.
** Representing their love for this one, the Dark Eldar have poisoned weapons as an upgrade in ''TabletopGame/{{Warhammer 40000}}: VideoGame/DawnOfWar [[{{Sequelitis}} Soulstorm]]''. Note that according to the fluff it's usually nonlethal, as Dark Eldar want to take [[FateWorseThanDeath prisoners]]. [[GameplayAndStorySegregation In-game, it just makes their weapons deadlier]].
** This sometimes seems a little unnecessary, given the tech levels in TabletopGame/{{Warhammer 40000}}. For example, the Callidus Assassin is armed with a gun that rips your brain apart, a sword that can cut through anything in the universe except the Great Old Ones who invented it... and a poisoned knife. Which in some circumstances is [[RockBeatsLaser exactly what you need]].
* ''TabletopGame/{{GURPS}}: Ultra-Tech'' has a shuriken made of "coherent sound" that can be used to deliver poison when it attacks.
* ''TabletopGame/{{Exalted}}'': [[GreenThumb Wood Aspected]] Dragon-Blooded are capable of producing a magical plant toxin from their [[BattleAura anima]]. They can poison you with a simple touch or unarmed attack, or with a very basic Charm can also channel this toxin through a weapon.
* Essentially, virtually every action adventure-based tabletop [=RPG=] (which is to say, most of them) will have at least a few paragraphs on the effects of poison on player characters -- from a simple "save or die" to lovingly detailed descriptions of a given poison's exact effects over time. Some systems (notably early editions of [[TabletopGame/DungeonsAndDragons (A)D&D]]) then promptly go out of their way to make the use of poison ''by'' player characters in turn as impractical as possible or even ban it outright, while others won't bat an eye.
** In D&D Fourth Edition, poison use is one of the main shticks of the Executioner Assassin player class. The class makes a certain number of uses of poison each day (determined by level) which can be applied to weapons or used directly on enemies. Other classes have access to poison-based powers as well, but since the poison damage type is resisted by more creatures than any other damage type, it's not the best type of damage to specialize in.
** 3rd Edition has a 5% chance of accidentally poisoning yourself when applying acid to a blade, although certain classes, such as Assassins, are trained to avoid this. It's still not very practical, however, as the good stuff is expensive, and by the time you can avoid it in mass quantities, most enemies will make their Saving Throw easily.
[[/folder]]

[[folder: Theater]]
* Poisoned weapons featured in a number of Shakespeare's plays, perhaps most prominently in ''Theatre/{{Hamlet}}''.
[[/folder]]

[[folder: Videogames ]]
* In a flashback of ''VideoGame/SuikodenII'', it is revealed that a previous border-skirmish between the Highlands and the Jowston Alliance was to be settled with a contest of champions - a duel between the greatest hero of both sides. That those two happened to be personal friends was supposed to make it into an honorable fight. However, when the battle was joined, the hero of Jowston, Genkaku, refused to even lift his sword. Eventually, Highland's hero had no choice but to simply disarm him and claim victory. Genkaku was condemned as a traitor and banished to Highland... but later, it was revealed that the Major of Jowston had surreptiously poisoned Genkaku's weapon in order to ensure a victory - but Genkaku had realized this. If he had let this subterfuge be known, it would have triggered renewed hostilities between Jowston and Highland, so instead, he simply refused to swing his poisoned blade...
* In ''VideoGame/SuikodenV'' [[spoiler:Lyon]] is stabbed and near-killed with a poisoned dagger.
* Some weapons in the ''Franchise/FinalFantasy'' series inflict the "Poisoned" [[StandardStatusEffects status effect]] on enemies when they hit.
** In ''VideoGame/FinalFantasyV'', Sword Mages/Mystics can enchant their swords with the poisonous Bio spell, adding magical poison to their attacks.
** In ''VideoGame/FinalFantasyVII'', any weapon with two linked materia slots could be associated with an element or status effect, including poison.
** In ''VideoGame/FinalFantasyIX'', the Rune Tooth and the Poison Knuckles can both inflict poison, while the Scissor Fangs can inflict the more dangerous venom.
** In ''VideoGame/FinalFantasyX'', you can give any weapon this ability.
** ''VideoGame/FinalFantasyXI'' has poisoned weapons as well, but they're generally [[AwesomeButImpractical not that useful.]]
** In ''VideoGame/FinalFantasyMysticQuest'', {{ninja}} Tristam's shuriken are imbued with poison and paralysis abilities.
* [[KarmaMeter Possible]] hero example: [[Franchise/MassEffect Commander Shepard]] can equip his/her weapons with Polonium rounds (if you can handle enemies breaking down into [[NightmareFuel green vapor]] after death).
* The Assassin class in ''[[VideoGame/BaldursGate Baldur's Gate II: Shadows of Amn]]'' can poison their weapons. There are also poisoned arrows.
** The poison is also applied to any traps the assassin deploys while under the 'poisoned weapon' effect.
* The Hrunting in ''[[VideoGame/CastlevaniaChroniclesOfSorrow Castlevania: Aria of Sorrow]]'' is an example of a poisoned sword.
** If you have the right combination in ''[[VideoGame/CastlevaniaCircleOfTheMoon Circle of the Moon]]'' (Manticore and Mercury), you can make your whip poisonous. Another combination (Manticore and Mars) turns it into poisonous claws.
* ''VideoGame/DungeonsAndDragonsOnline'' features weapons with the poison trait, doing extra 'poison' damage and some kind of ability damage. Rogues also have an enhancement available that adds additional 'poison' damage to their attacks. The MasterPoisoner Ninja Spies are the most dangerous with their own brand of poison that increases in toxicity while worsening damage from stock poison weapons. Enemies are worse; one poisonous sting or bite from some medusas or demon will outright kill you if not immediately treated.
* In ''VideoGame/WorldOfWarcraft'', rogues can apply various poisons to their weapons, granting extra damage or certain special effects when an attack lands.
** During a duel between Garrosh and Cairne for leadership of the Horde, Magatha Grimtotem poisoned Garrosh's weapon (taking advantage of his ignorance of the pre-fight blessing tradition) so that a single lucky blow defeated the almost victorious Cairne. Garrosh was less than pleased.
** Some of the buffs you can get from the Mantid Paragons while questing in the Dread Wastes poison your weapons. For example, Xaril the Poisoned Mind coats your weapons with a poison that after eight hits on a target, severely damages the target and stuns nearby enemies.
** In Mists of Pandaria, [[spoiler:Vol'jin]] gets stabbed with a weapon that interferes with his regeneration capabilities. It's up to you to find the herbs necessary to heal him.
* Players in ''VideoGame/RuneScape'' can create poisons to use on daggers, arrows, spears and a few throwing weapons using the Herblore skill. There are three poisons, each stronger than the previous, and they're made from a herb and a dragon scale, a cactus spine and spider eggs, and poison ivy berries and belladonna respectively, from weakest to strongest. Belladonna is potent enough to strongly damage the player just when it's touched with bare hands.\\
\\
Additionally, a small octopus caught on a tropical island, and when somewhat heated it becomes as poisonous as the strongest poison - then it can be ground into a paste that can be applied to spears only, though. The reason of such a limitation? [[ObviousRulePatch There is no real one.]] Only the mentioned select few above weapons can be poisoned, too - many other bladed weapons can't be.
* Poisoned weapons are featured frequently in ''VideoGame/FireEmblem''. There's usually no way for you to get one though, making them UnusableEnemyEquipment (or rather, Unobtainable Enemy Equipment). In games that allow you to steal or otherwise obtain an enemy unit's equipment, the poisoned weapons are converted into [[GoodWeaponEvilWeapon plain old iron weapons]] when in your possession.
** In ''[[VideoGame/FireEmblemTellius Radiant Dawn]]'', you can disarm an opponent and steal them and they'll still be poisonous. Not really worth it, since they do less damage than iron weapons, but it is still possible should one want to use them.
*** A unique weapon of this type is the Valaura from the same game, a poisonous {{Light|EmUp}} [[HolyHandGrenade Magic]] tome. Explained that it's corrupted magic.
* Arrows in ''NetHack'' can be poisoned, which can lead to much frustration since poison can sometimes cause instant death.
* VideoGame/{{Magicka}} has several poisoned weapons. They also are the only way to create poison elementals.
* ''[[VideoGame/{{Diablo}} Diablo 2]]'' allows low-level Necromancers to enchant daggers with poison. Poison enchantments on weapons was also quite common, even though these enchantments were generally far from lethal in any way.
* There's Bruno from Quest for Glory I and [[spoiler: the same Bruno's]] in ''VideoGame/QuestForGloryV'. The poisoned daggers were a plot point in the second. The hero could obtain and even use one. Not recommended if you're playing a [[LawfulGood paladin]].
* ''VideoGame/DeusEx'' features poisoned crossbow bolts, which serve as tranquilizer darts (though they kill ''you''). In [[VideoGame/DeusExInvisibleWar the sequel]] there is a similar dart gun, but also a hidden, poisoned dagger. Striking your enemies with it makes them cough from the poison in addition to extra damage. This is especially useful as continuous strikes will have your opponent hacking so much he won't have the chance to fight back.
* ''[[VideoGame/TheElderScrollsIVOblivion The Elder Scrolls IV: Oblivion]]'' lets you poison your weapons. Any potion you make (or find) which only has negative effects will be treated as a poison and be applied to your weapon (delivering its effects to the next enemy you strike with a melee weapon or applying them to the next arrow you fire). This causes some confusion as to how a [[DropTheHammer warhammer]]-[[CarryABigStick or other blunt weapon,]] which [[MindScrew has no method of actually transmitting the poison into the host's body]]-can be poisoned in the same manner as, say, [[HeroesPreferSwords a sword]] or [[AnAxeToGrind battleaxe/waraxe]].
** In ''VideoGame/TheElderScrollsVSkyrim'', poison returns, but further testing one's WillingSuspensionOfDisbelief. A master of pickpocketing can reverse pickpocket a poison vial into their possession to poison them without the recipient noticing.
* ''VideoGame/BattleForWesnoth'' has a Poison weapon special, used (in mainline) on Orcish Assassins' throwing knives, and Ghouls' claws. This ability turns both, especially Orcish assassins into DemonicSpiders
* The Dart Gun from ''VideoGame/{{Fallout 3}}'' utilizes Radscorpion venom, and will instantly cripple the victim's legs as well as causing damage over time; the effect stacks up with the number of darts hitting the enemy. Interestingly enough, a sting from an actual Rad-Scorpion does not cause the crippling effect, only the initial damage and HP drain.
** The Ant-Agonizer's Ant Sting knife also has a poison effect.
** ''Point Lookout'' has the Fertilizer Shovel.
** ''VideoGame/FalloutNewVegas'' ups the ante, by allowing you to craft numerous types of poison and apply them to any melee weapon. It wears off after one use, making it less useful on standard weapons, but kickass on thrown ones.
* ''VideoGame/{{Myst}}'': According to Achenar's journal in the fourth game, he used poisoned spears to kill the two large sea monsters (known as Cerpatees) in Haven.
* In ''VideoGame/AssassinsCreedII'', Ezio can get a poison upgrade for his hidden blade. It's the quietest weapon in the game, and because it has a delayed effect, you can poison a target and then get long gone before the target finally dies.
** An interesting bug in the game means that if the poisoned target, while flailing around uncontrollably, hits anyone, all the guards will blame you and go into high alert.
* ''VideoGame/MonsterHunter'' series: Poisoned weapons do exist, but they behave a little differently from the norm. First, each monster has its own tolerance to poison -- Bnahabra die instantly from poison smoke, while bigger monsters tend to resist it more readily. Also, each monster takes a given amount of damage maximum from the poison, and no weapon can inflict more or less. That said, a weapon's Poison attribute is in fact its virulence - a higher attribute means that the poison starts doing damage with fewer blows. Neurotoxins (paralysis) and sleeping agents (sleep) behave in the same way.
* ''VideoGame/{{Exile}}'' and ''VideoGame/{{Avernum}}'' give players the ability to poison melee weapons or arrows. Handy for taking out that nasty spellcaster hanging out in the back, as multiple hits from poisoned weapons makes the poison worse. There's also the Alien Blade, which constantly drips poison.
** There are enough enemies dealing poisoned attacks to make poison resistances and cures necessary. Same with the ''{{Geneforge}}'' series.
* Early FPS/RPG ''{{Strife}}'' allows you to use poisoned bolts for your crossbow, turning it from your weakest weapon to a OneHitKill weapon on grunts.
* ''VideoGame/CommandAndConquerGenerals'' allows the [[{{Qurac}} GLA]] to infect their tank shells with toxins given the proper upgrade. [[MadScientist Dr. Thrax]], in the ''Zero Hour'' expansion, takes it UpToEleven and places poison on ''everything'' in his arsenal.
* The Latin Junta in ''VideoGame/MarchOfWar'' have a similar combat philosophy to Dr. Thrax.
* ''VideoGame/DarkSouls'' has some poisoned weapons, throwing knives, and arrows. Also, enemies in Blighttown use poison darts and giant clubs.
* In ''VideoGame/LeagueOfLegends'' [[BadassAdorable Teemo]] uses a blowgun with poisoned darts, [[RodentsOfUnusualSize Twitch]] uses poisoned crossbow bolts, and [[{{Pirate}} Gangplank]] soaks his blades in grog - which is apparently pretty strong stuff, because it deals damage over time and slows enemies it hits. [[SnakePeople Cassiopeia]] and [[MadScientist Singed]] cut out the middleman and simply blast people with contact poison or gas.
* The Viper Blade and Scorpio Staff can inflict poison on targets in ''VideoGame/KidIcarusUprising''. And any weapon can be made poisonous with powers and customized abilities.
* One of the robots in ''TheJourneymanProject'' shoots the player with a tranquilizer dart that will kill them if they try to leave the laboratory without finding an antidote first. The same dart gun is used to neutralize the BigBad at the end.
* Certain ''BattleRealms'' units have weapons that have poisoned. The Serpent Clan's Zen Master Shinja dual wields poisoned swords, while the Crossbowman and Bandit can have their crossbow bolts tipped with poison. Lotus Clan Diseased Ones exude a poisonous gas to attack.
* In ''SyphonFilter: The Omega Strain'', Lian Xing gets to use poisoned shurikens while on a ninja-style stealth mission disguised as a Sherpa.
* The [[GameBreaker Game Breaking]] Nightglow Sword in ''VideoGame/JadeCocoon'' delivers a guaranteed poison status to nearly any enemy and all but one of the ''bosses''.
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[[folder: WebComics]]
* In ''Webcomic/RiceBoy'', T-O-E (one of the good guys) carries a poison blade, possibly anticipating that he would have to fight Golgo, and that poison was the only thing that could kill Golgo.
* ''Webcomic/TheOrderOfTheStick'' has Daimyo Kubota utilizing a poisoned ring to kill [[spoiler: Therkla after she decides to act in a way that is not in his best interests]]. Con damage is a bitch, isn't it? He's even DangerouslyGenreSavvy enough to avoid [[HoistByHisOwnPetard the typical downside of this trope]]: instead of carrying the antidote when the time comes to use the poison, he drinks the antidote in advance, so he'll be immune to the poison just in case he gets scratched, but his intended victim won't be able to obtain a cure in time. And to not be beaten in GenreSavvy twice, [[CrazyPrepared Elan learns Neutralize Poison afterwards]].
* ''Webcomic/GirlGenius'' not only [[http://www.girlgeniusonline.com/comic.php?date=20110907 hints]] that [[McNinja Smoke Knight]]'s weapons are poisoned, but shows how it can be used for an insult (what with those poisonous frogs and all):
--> '''Tarvek''': Violetta -- have you been licking your ''knives'' again?
** Violetta also uses a variation. Zola high on "[[SuperSerum Movit]] #[[UpToEleven 11]]" receives a blowdart in the back and mocks the attempt... until Violetta explains the nature of the poison.
--> '''Violetta''': Tsk, I know that. That wasn't poison, that was more Movit #11. Now all I have to do is [[ExplosiveOverclocking watch you combust.]]
*** More people with Smoke Knight training have shown up, and every time anyone has been hurt by them, a poison was involved. It's like they don't have any ''non''-poisoned blade.
** [[http://www.girlgeniusonline.com/comic.php?date=20120523 Wulfenbach commandos]] had poisoned dirks. Fast-acting stuff, apparently.
* In ''Webcomic/{{Strays}}'', [[http://www.straysonline.com/2011/10/page-191/ Feral's foe uses them.]]
* In ''Webcomic/{{Digger}}'', Boneclaw Mother augmented her NaturalWeapon by coating the claws of her left paw in poison, in case things got desperate. Afterwards, she had to clip them down to the quick to remove the posion.
[[/folder]]

[[folder: Web Original ]]
* ''Roleplay/SurvivalOfTheFittest'': Blood Boy's assigned weapons are an Ida (an African sword) and a vial of poison meant to be applied to the blade.
* Phase (Ayla Goodkind) of the ''Literature/WhateleyUniverse'' is now carrying some poisoned throwing darts. When chided for it by an instructor, she shows she also carries a syringe of antidote.
[[/folder]]

[[folder: Western Animation ]]
* In one episode of ''WesternAnimation/TheSimpsons'' with Homer's brother, Herb, Bart is given a membership card to the NRA as a present from Herb so Bart can buy a machinegun when he's older. He asks if he can get armour piercing cyanide-tipped bullets to go with it. Herb replies, "It's in the constitution, son."
* In ''WesternAnimation/{{Sandokan}}'', one evil tribe uses poisoned spears.
[[/folder]]

[[folder: Real Life ]]
* Poisoned weapons are used to this day by South American tribes, who use blowdarts smeared with the secretions of poisonous frogs.
* Back in the day, Chicago gangsters were known to use poisoned bullets. Can be useful if you miss the enemy's vitals. Yeesh.
* A school superintendent was murdered in the 70s. He was shot eight times, and the coroner found traces of cyanide on the bullets. Somewhat unsurprisingly, though, the official cause of death was ''being shot eight times''.
* Poisoned bladed weapons in real life have always been uncommon and not very effective because successful strikes make almost all the poison bleed out almost as soon as the wound is made (not to mention that with such a weapon, simply damaging a major organ or fatality via blood loss works with greater speed and reliability). Blowdarts, throwing spikes and the like are exceptions because they cause very little bleeding, and do manage to inject useful amounts of poison into the body.
* The word ''toxic'' comes from the Greek ''toxikon'', a poison made from yew extract for use on arrows (''toxa'').
* A common battle tactic in medieval times was to fire [[DungFu a bag of feces]], dead animals or even [[GrievousHarmWithABody dead humans]] over a castle gate, as a quick and easy way to spread pestilence and sicken the defenders. Sticking your sword in some pig shit and then running it through a guy also worked wonders, since it dramatically reduced the likelihood he'd recover and come back to fight you again later.
** No need to bother with pig shit when the [[TheDungAges human kind is always readily available]].
* Similarly, nomadic peoples of the steppes sometimes employed this method or its variant on their arrows.
* British scientists during WorldWarII worked upon a grenade shooting dozens of poisoned needles instead of your common shrapnel. The project was scrapped; the [[CoolButInefficient sadism-to-usefulness]] ratio was too large.
* During TheVietnamWar the Viet-Cong would smear human feces on Punji sticks (a simple spike, made out of wood or bamboo, generally [[SpikesOfDoom placed upright]] in the ground). The injury, normally to the foot or lower leg, would almost instantly swell up with infection. Unless treated quickly, loss of limb or death would occur.
* Georgi Markov, assassinated by the KGB with a ricin-filled dart fired from an umbrella.
* Early bullets usually consisted entirely of lead, and sometimes copper (if it was more widely available in the region). Both are toxic metals, and often caused secondary poisoning in the man they shot, assuming he lived long enough for that to be an issue. It is for this that "lead poisoning" became a common euphemism for getting shot. Modern bullets often utilize both. Its not that they're intended to be toxic, its just that they're cheap and have good ballistic properties (due to high density); their toxicity is more of a beneficial side effect.\\
Worst still are higher end bullets made of tungsten carbide and depleted uranium. Tungsten carbide is rather toxic, but has excellent hardness and ballistic properties due to its high density. However, most military forces prefer the much cheaper depleted uranium (a left over from nuclear programs thats of no use for bombs or in reactors, and unlike tungsten doesn't need to be heated to 3000 degrees Celsius to melt into shape), which is almost as dense, slightly radioactive, self sharpens upon breaking (leading to better armor penetration), makes for a fairly good incendiary weapon, and on top of all that is still very toxic in the conventional chemical way.
** A recent development is called Dense Inert Metal Explosive (DIME) that mixes powdered tungsten into explosives to make the explosion more localized (tungsten being the inert metal) in order to limit collateral damage and increase targeted destruction. One unintentional consequence is the medical side effects of this are that the victims are poisoned with tungsten powder and there is no surgical way to treat this condition.
* Some monitor lizards' bites are essentially a natural version of this; they harbor enough infectious bacteria that their saliva is toxic even to large animals. There is speculation that a monitor lizard also produces a small amount of true venom, but usually infection is what kills their prey, and captive monitor lizards have a cleaner mouth and therefore a less deadly bite.
[[/folder]]
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