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->''"All things must wither and die. Let root rot and bower blight, to feed the pestilence of abandoned hope."''
-->-- '''Aghalhor the Bringer of Poxes''', ''TabletopGame/{{Warhammer 40000}}''

The Plaguemaster is a character who delights in disease and pestilence, gleefully spreading contagions and poxes across the world ForTheEvulz. Leprous wounds, eyes scabbed over with crusted filth, weeping sores, unburied corpses piling up in the streets - these are a few of their favorite things, and they'll use whatever technological or supernatural talents they possess to bring about TheEndOfTheWorldAsWeKnowIt with a hacking, bloody cough.

Typically a Plaguemaster's physical form is just as ravaged by disease as his victims, but due to the character's empathy for illness, they frequently enjoy [[IdealIllnessImmunity immunity to the negative effects of the diseases they carry]], and may even have supernatural toughness ''because'' they're a walking plague ward. The Plaguemaster's obsession is often [[AstonishinglyAppropriateAppearance reflected in his appearance]], either bloated with rot and cancerous growths, or wasted and skeletal... but the most insidious Plaguemasters [[TheyLookJustLikeEveryoneElse appear perfectly normal]], all the better to spread disease without suspicion (or they are [[TyphoidMary Typhoid Marys]]).

The technologically adept {{Plaguemaster}}s may use {{Synthetic Plague}}s. If the Plaguemaster isn't immune to their diseases, you can expect them to die by [[HoistByHisOwnPetard becoming infected with their own plague]].

Very rarely, characters will have [[BlessedWithSuck powers of pestilence but lack a real Plaguemaster's interest in using them]]. But for the most part, any character with plague-related abilities [[BadPowersBadPeople is quite clearly a villain]].

See ThePlague or TheVirus for what the Plaguemaster spreads. If faced in combat, the Plaguemaster is usually a GradualGrinder. Their activities are always a great excuse to introduce a ZombieApocalypse. SisterTrope to PoisonousPerson. Compare TyphoidMary, someone who unwittingly infects people with a disease they themselves are immune to.



[[folder:Anime and Manga]]
* [[MadDoctor Cioccolatta]] from Part 5 of ''Manga/JoJosBizarreAdventure''. With a MorallyAmbiguousDoctorate (he used to torture patients for his own pleasure before joining the mafia), his [[GuardianEntity Stand]], Green Day, spreads a wicked mold that devours anyone who comes into contact with it within seconds. He has a ''lot'' of fun with this power.
** Pannacotta Fugo from the same the same part. His Stand, Purple Haze, creates a deadly flesh-eating virus which can melt down human flesh in 30 seconds. However unlike Cioccolatta, [[BadPowersGoodPeople Fugo is a more pleasant and caring person]], although he does [[BewareTheNiceOnes have a short temper]].
* The Dorumekian Theocracy from ''Manga/NausicaaOfTheValleyOfTheWind'' uses fungal spores in warfare.

[[folder:Card Games]]
* ''TabletopGame/MagicTheGathering''
** One of Black's domains is inflicting disease. There are many cards with a Plaguemaster flavor; for example, the [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=45327 Phyrexian Plaguelord]].
** This is the hat of the Phyrexians, and ''Scars of Mirrodin'' gives them powers to match; via -1/-1 counters and poison (can't remove it, get 10 and you lose).
** The Theros block also included [[http://gatherer.wizards.com/Pages/Card/Details.aspx?multiverseid=380469 Pharika, God of Affliction]].

* Infectious Lass (one of the Legion of Substitute Heroes in ''ComicBook/{{Legion Of Super-Heroes}}'' comics) is a [[BadPowersGoodPeople heroic version of this.]]
* Bile from Omega Flight in the MarvelUniverse.
* Pestilence from [[ComicBook/XMen The Horsemen of Apocalypse]].
* One volume of ''ComicBook/{{Fables}}'' shows a war council among TheEmpire where one plan is to send many of their warlocks into our world and use magical plagues as part one of the end of the world.
* Judge Mortis, one of the Dark Judges from the ''ComicBook/JudgeDredd'' universe. The touch of Mortis brings decay!
* ''ComicBook/AndersonPsiDivision'': The Sisters of Death have a few cousins who proceed to spread death and destruction around the Mega City. A particularly nasty one involves a blistering plague that turns people into melting bags of puss.
* [=DiNA=]: Simmons, the ''Crimson Plague'', capable of destroying a planet in a night, is either this or a TyphoidMary. Once a month, her poisonous blood becomes an airborne virus.
* ''ComicBook/WynonnaEarp'': In #4 of the 2016 series, Wynonna and the Black Badges have to stop a scientist who has given himself the power to transmit a zombie plague through his hands.
* ComicBook/WonderWoman foe Doctor Poison began as a bog-standard goofy MadScientist (with an extra dose of YellowPeril thrown in), but began veering toward this in her later, DarkerAndEdgier incarnations.
* Hemo-Goblin, the infamous "white supremacist [=AIDS=] vampire" from ''The New Guardians''.
* The minor Marvel villain Contagion was basically the anthropomorphic personification of the very concept of disease, and at one point infected Wolverine with AIDS, Australian bat lyssavirus, Black Creek Canal virus, Camelpox, Dengue fever, Echovirus 9, Feline immunodeficiency virus, Hemorrhagic fever, the whole Influenza alphabet, Kaposi sarcoma, Kilham rat virus, Klongo, Marburg virus, Mengele virus, mumps, Oropouche, Parapoxvirus, Smallpox, Sowbane, Strain XV infection, Syphilis, Toxoplasmosis, [=UR2=] sarcoma virus, West Nile virus, WVU virus 2937, Xenopus, and Zoysia mosaic virus all at once. His powers later go BeyondTheImpossible as he gains the ability to do things like turn diamond into coal and make people allergic to their own thoughts, which he could also replace with his own using another virus.

[[folder:Fan Works]]
* Rei from ''Fanfic/ThousandShinji'' is an AntiHero example. When she converts to ''[[TabletopGame/{{Warhammer 40000}} Nurgle, Chaos God of Decay]]'' she gains mastery over viruses, bacteria and sickness, and her whole body becomes a factory of toxins and diseases.

* The antagonist in ''Film/TwelveMonkeys'' released a deadly plague in multiple cities across the world which ended up causing the human survivors to live underground.
* Typhoid Mary from ''Film/{{Elektra}}''. Film version only; comic book Mary has PsychicPowers instead.
* The villain of ''Film/LaraCroftTombRaiderTheCradleOfLife'', Jonathan Reiss, being a bio-terrorist, is this.
* The Witch Queen from ''Film/TheLastWitchHunter'' has this as her primary ability, and her endgame involves creating the second Black Death plague to end human civillization.

* The Cener Druids in the ''Literature/LoneWolf'' gamebook series. They first play a major role in the aptly-titled ''The Plague Lords of Ruel''.

* The immortal "H" from Creator/RogerZelazny's ''To Die in Italbar''. When he meditates in a certain way, his immune system goes into a sort of SuperMode that can instantly cure anyone of any disease simply by being in his presence. However, when he goes long enough without meditation, he begins sort of ''radiating'' every disease he's ever been exposed to. When, due to a number of mistakes and understandings, he goes MUCH too long without meditation [[spoiler:he is driven completely insane, eventually reaching the point where he can kill entire planets with a brief tour, and his powerful immune system can't keep him from being covered in open sores]]. This is because it eventually turns out that his powers are granted by communion with an alien goddess of life [[spoiler:and death]].
* In ''Literature/GoodOmens,'' the AnthropomorphicPersonification of Pollution is one of the HorsemenOfTheApocalypse. Pestilence quit decades ago over that whole "penicillin" thing.
* Victor from ''Literature/TheCompanyNovels'' is turned into an unwitting plaguemaster by the Plague Cabal, unknowingly inflicting deadly disease to those around him at Labienus' whim. When he does find out, Labienus uses it to leverage him into becoming TheMole, since he can activate Victor to kill anyone he's close to if he doesn't obey. [[spoiler:He pushes Victor a bit too far in the end, and suffers AndIMustScream by way of one of his own plagues when TheDogBitesBack.]]
* Typhoid Larry from Perry Moore's ''Literature/{{Hero}}'' is one of the few heroic versions of this trope.
* The character [[spoiler:Sebastian Gault]] becomes the King of Plagues in Jonathan Maberry's appropriately-titled novel, ''The King of Plagues''. His job, within the secret society which gives him that title, is to spread devastating diseases across the globe so that his organization can profit from the chaos...somehow.
* In ''Literature/SeptimusHeap'', Queen Etheldredda uses her pet Aie-Aie to spread a Sickenesse among all those who displease her.
* John Connolly's short story The Cancer Cowboy Rides has Buddy Carson, who spreads cancer with a touch.
* Creator/EdgarAllanPoe's short story "Literature/TheMasqueOfTheRedDeath" revolves around the nobility of an unspecified country escaping the titular pestilence by locking themselves away in the prince's country estate, where the disease eventually manifests as a [[MalevolentMaskedMen masked]] guest at a ball.
* The BigBad of ''Literature/TheTraitorSonCycle'' has a habit of creating and sending out {{Mystical Plague}}s to weaken the heroes' forces.

[[folder:Live-Action TV]]
* ''Series/StargateSG1'' had Linnea, who was known on her home planet as the Destroyer of Worlds. She created a virus that wiped out most of the population, and tricked SG-1 into letting her escape with them from the prison they were all in.
** They later [[spoiler:unwittingly ran into Linnea on another planet, Vyas, where she managed to create ''another'' plague despite the planet's 1920s-era technology. However, ''this'' plague had the effect of de-aging everyone and wiping their memories. As a result, she doesn't remember who she is. They let her live after convincing her not to take the treatment she develops.]]
** And then there was Nirti - a Goa'uld interested in biology and virology.
** And the Ori Priors
* The [[MonsterOfTheWeek damned soul of the week]] from the ''Series/{{Brimstone}}'' episode "Carrier."
* [[HorsemenOfTheApocalypse Pestilence]] from ''Series/{{Supernatural}}'', obviously. He's responsible for spreading swine flu so he can later distribute a vaccine that carries the ''real'' plague that will destroy humanity, a strain of the [[PlagueZombie Croatoan Virus]].
* The test subjects from the ''Series/DoctorWho'' episode "New Earth". Cloned humans that are a living collection of various ailments, they killed whoever they touched by infecting them with their diseases.
* [[MagicalNativeAmerican Hus]] from the ''Series/BuffyTheVampireSlayer'' episode "Pangs" magically infected Xander with diseases brought to North America by European settlers.
* In the ''Series/{{Charmed}}'' episode ''Awakened'', Piper is dying of a disease, and Prue and Phoebe become desperate enough to try and cure her with magic. It works, but unfortunately the doll used in the spell becomes animate, and has the power to infect people with the disease by poking them with its sword.
* Jha'dur from ''Series/BabylonFive'' was a war criminal infamous for at least one case of exterminating a whole planetary population with Stafford's Plague.
* Two episodes of ''Series/BodyOfProof'' revolved around an eco-terrorist who aimed to combat overpopulation by [[spoiler:infecting himself with a particularly strong virus related to Ebola and spreading it around the city by smearing his blood on things that a lot of people touched, like the handrails on subway steps.]]
* The ''Series/LawAndOrder'' episode "Carrier" has the detectives tracking down a street kid with AIDS who deliberately intends to infect as many girls with HIV as possible.
* An episode of ''Series/CriminalMinds'' had a psycho whose MO was to infect people with rabies, and hold them captive until they died from it, filming the entire thing.
* ''Series/TheNewAvengers'': Professor Turner in "The Midas Touch". Turner has found the ultimate carrier for a host of deadly diseases, calls him Midas and offers him to the highest bidder in exchange for gold.

[[folder:Mythology and Religion]]
* [[HorsemenOfTheApocalypse Pestilence]].
* Polytheistic religions sometimes have deities of disease and sickness:
** Finnish: Kipu-tyttö - goddess of disease.
** [[Myth/ChineseMythology Chinese]]: Lu Yueh - god of epidemics.
** [[Myth/NorseMythology Norse]]: The goddess Hel could cause plagues, diseases and pestilence with the wave of her hand.
** [[Myth/ClassicalMythology Greek]]: Apollo, which is rather ironic considering he is also a [[LightIsNotGood god of light]].
** [[Myth/MesopotamianMythology Mesopotamian]]: Nergal, the god of war, death, disease, and the underworld. He was associated with the midday sun and the summer solstice, and the terrible heat that came with them.
** [[Myth/EgyptianMythology Egyptian]]: The war goddess Sekhmet was primarily a goddess of righteousness, but could be a complete KnightTemplar about it. Her attributes were derived from Ra, the sun, but she embodied the destructive aspects of it, with disease, the destructive heat of the sun, and infertility to crops being some of them.
* The Nuckelavee, an evil, ocean-dwelling fairy from Scottish folklore.
* Some of the demons described in the ''Literature/ArsGoetia'' could be called upon to evoke various kinds of this. Thing is, only one of them, Marbas, was a generalist (his other powers being curing disease, and BalefulPolymorph. One leads to quite a con game, the other to [[FridgeHorror the ultimate in biological warfare]]). Leraje, Sabnock, and Vepar apparently all specialized in battlefield disease. Leraje caused arrow wounds to putrefy, while Sabnock and Vepar called maggots in to colonize wounds in general.
* In Hawaiian Mythology, although Poli'ahu was primarily a benevolent goddess of [[AnIcePerson snow and ice]] [[note]] Yes, there ''is'' snow in UsefulNotes/{{Hawaii}}, it's just usually confined to high mountain peaks, such as Mauna Kea, where Poli'ahu was said to live. [[/note]], she did inflict chills and fever on her rival for love, Hinaikamalama [[spoiler: actually a form of the fire goddess Pele, which, besides them being diametrically-opposed elemental forces, is a ''major'' reason they don't get along]], and on her ex-fiancé Aiwohikupua for [[YourCheatingHeart cheating on her]] with Hinaikamalama on what would have been their wedding day.

[[folder:Tabletop Games]]
* In ''TabletopGame/{{Warhammer}}'' and ''TabletopGame/{{Warhammer 40000}}'', this is the portfolio of the [[CosmicHorror Chaos God]] Nurgle. He spreads terrible diseases and plagues, and recruits from victims who in their delirium turn to him as a way to end their suffering - he is the god of stagnation and despair, after all, and gains his power from his adherents abandoning all hope and throwing themselves at his mercy. Nurgle's disciples tend to be bloated with rot, but as part of their deity's favor are unable to die from the poxes they carry. Some of his servants even become supernaturally strong or enduring ''because'' of their corruption, enabling them to work tirelessly to spread Nurgle's "gifts". Bizarrely enough, "Papa Nurgle" is one of the [[AffablyEvil most jovial and kindly]] of the [[EldritchAbomination Chaos entities]], cuddling and caressing his nauseating daemons, and showing his affection for his worshipers by inventing disgusting new diseases for them to enjoy.
** The ''TabletopGame/BlackCrusade'' supplement ''The Tome Of Decay'' explicitly makes Plague Marines immune to all negative effects of diseases, but not to the diseases themselves, so they can catch and spread them.
** Also in TabletopGame/{{Warhammer}}, the Skaven (a race of humanoid rats) have a clan dedicated to cataloging, creating and spreading diseases.
** It is rumored that Nurgle loves all life equally. That is, he values a human just as much as a bacterium. Since they outnumber us billions to one, you get the god of plagues.
* The ''TabletopGame/DungeonsAndDragons'' expansion ''The Book of Vile Darkness'' introduced a prestige class called the Cancer Mage, which is just as disgusting as it sounds. Two words: [[{{Familiar}} Cancerous Companion]]. It's actually sentient, can communicate telepathically with the Cancer Mage, and is a friend that's [[BodyHorror always with you]].
** Also horrifically broken because of the very book it was printed in (one of the diseases gives you Stat Bonuses, and you become immune to the drawbacks).
*** However, its final power is becoming the disease itself and infecting people. This would be all well and good if most worlds didn't have lots of clerics, who can kill the Cancer mage with a 3rd level spell if the CM fails their weakest save. Cancer mages tend not to use that ability outside of settings where the gods have legged it.
* A number of these appear in ''TabletopGame/{{Deadlands}}'':
** Ernst Biren is a particularly infamous one.
** A number of monsters have this as their basis -- the Pox Walker and the Plague Rider, in particular, specialize in spreading diseases. Both are born of the [[HumansAreBastards White Man's willingness to give diseased blankets to Indian tribes to kill them off and then grab their land]].
** [[spoiler: Pestilence, of the Four HorsemenOfTheApocalypse, is one of the Reckoners. His Servitors tend to follow this trope, naturally]].
* ''TabletopGame/{{Pathfinder}}'' includes several of these:
** Pestilence, of the Four HorsemenOfTheApocalypse, is one of the four rulers of the [[NeutralEvil Daemons]].
** The Pairaka of the Divs is a species of these -- horribly, they're the Div equivalent to [[HornyDevils Succubi]], using their sex appeal to lure mortals into physical congress and then sending them off dying of disease.
** One of the [[AlchemyIsMagic Alchemist]] archetypes is the Plaguebringer, from the ''Advanced Races Guide'' sourcebook, whose specialty revolves around creating disease weapons and toxic bombs instead of using [[VoluntaryShapeshifting mutagen]]. It's most associated with the Ratfolk race, in a ShoutOut to the Skaven above. Even outside of this archetype, alchemists can still build towards this, with powers inspired by other examples from this section (including the ability to turn a tumor into a familiar - and this version can detach itself and act like an animal).
*** Similarly, instead of the paladin's Divine Health ability (which renders them immune to disease), Antipaladins gain the "Plaguebringer" ability at 4th level, which merely renders them immune to the ''effects'' of diseases but still allows them to carry and spread the disease.
* ''TabletopGame/VampireTheRequiem'' features the Morbus [[PrestigeClass bloodline]] of the Mekhet. Every single one carries a disease in their blood, they can only feed effectively off of diseased mortals, and they have a bloodline-only Discipline that allows them to diagnose, halt, and aid the spread of disease. They're also persona non grata in many domains, as the [=CDC=] popping in to inspect that sudden outbreak of the bubonic plague can risk the {{Masquerade}}.
** In a way, the Anvari (who feed off of drug-laden blood and can alter body chemistry to be under the effects of various narcotics with their bloodline Discipline) and the Brothers of Ypres (who need "tainted" blood, but prefer poison, since their founder mutated as a result of feeding on those dying of chemical weapon attacks in UsefulNotes/WorldWarOne) are a PoisonousPerson equivalent to the Morbus.
* In ''TabletopGame/WerewolfTheApocalypse'', the wererats are almost a race of these. Unlike other werebeasts, who are born with their abilities, wererats create more of their kind by inflicting a lycanthropic infection on their human and rat relatives. They're generally batshit insane and their goal, besides saving the universe from the conformity-obsessed Weaver by plunging it into screaming chaos, is to "reduce" the human population using plagues. The Plague Lords are the most obsessed with this tack.
* Demnogonis from ''TabletopGame/MutantChronicles'' is Warhammer's Nurgle in different clothes.
* Shrouds with the Pestilence dominion in ''TabletopGame/{{Anathema}}'' can magically create and spread deadly diseases.

* The Lich King spent ''VideoGame/{{Warcraft}} III'' spreading a plague of undeath across Lordaeron. During ''VideoGame/WorldOfWarcraft'', the Forsaken's Royal Apothecary Society spends its time brewing horrifying diseases and testing them on prisoners in an attempt to create a toxin capable of wiping everything that isn't free-willed undead from Azeroth. Meanwhile, Noth the Plaguebringer is ExactlyWhatItSaysOnTheTin[[note]] Subverted in actual battle - he uses curses instead of diseases.[[/note]].
** In the Warcraft III [[GameMod map-game]] ''VideoGame/DefenseOfTheAncients'', the Venomancer is a creature that mastered the use of poisons.
** Warlocks and Death Knights each have a talent tree focused on this kind of stuff (the Warlock one doesn't actually use diseases but corrupting magical effects, but with talents with names like "pandemic" and "contagion" I'd say it's close enough).
* The Necromancer in ''VideoGame/{{Diablo}} 2'' has a whole skilltree devoted to poisons.
* The storyline of ''VideoGame/{{Prototype}}'' is eventually revealed to be a match between ''dueling'' Plaguemasters. On the one hand is Elizabeth Greene, sole survivor of the last virus outbreak and the game's BigBad, who in a partial subversion appears entirely human: even her OneWingedAngel form, once defeated, simply spits her out in her original human form. The other? [[spoiler: Protagonist Alex Mercer, who unwittingly ''is'' TheVirus itself. He also appears human, but unlike Greene, his powers manifest through monstrous - and awesome-looking - transformations.]]
** ''Videogame/{{Prototype 2}}'' now features a new battle between powerful Plaguemasters. Only in this case, Alex Mercer was responsible for the creation of the second plaguemaster, a soldier named James Heller who [[BadassNormal personally pushed his way through the hordes of viral mutants armed with nothing but his rifle]] and [[UnstoppableRage a compulsion to destroy as many creatures as possible before falling]]. James Heller is not only capable of shapeshifting like Alex, but he can also transmit a specialized strain of the Blacklight virus, whose effects induce massive tumors in the victim before erupting into a swarm of tentacles.
*** Also, later in the game, James Heller gains command over some of the infected abominations that stalk Manhattan.
* Adam from ''VideoGame/TraumaCenter'' is not only the Plaguemaster, having created GUILT from his own cells, but has also kept himself alive for over a hundred years in his [[NietzscheWannabe quest to "return death" to the world]]. [[spoiler: It's also suggested that the seeds of GUILT are found in all human DNA, so theoretically anyone could be another Adam.]]
* Kurodani Yamame from ''VideoGame/{{Touhou}}'', the local [[GiantSpider spider]] [[PettingZooPeople gi]][[CuteMonsterGirl rl]]. [[DarkIsNotEvil Actually a fairly nice]] {{youkai}}, as she tries not to actively use her powers unless she's angry-- but Symposium of Post-Mysticism suggests that she [[PowerIncontinence unwittingly]] [[TyphoidMary leaks plague]], and that the heroines of ''Subterranean Animism'' both came home with fevers.
** [[LivingToy Medicine Melancholy]] is truer to this trope, given that she ''loves'' to patter on about the effects of her poisons.
* ''VideoGame/VampireTheMasqueradeBloodlines'' features a doomsday cult calling themselves the Ninth Circle who operate like this. Since vampires in this system become permanent disease carriers if they feed from anyone with a blood-borne illness, they've decided to spread disease in an attempt to hasten [[TheEndOfTheWorldAsWeKnowIt Gehenna]].
* ''Franchise/TheElderScrolls'':
** Peryite, as the [[OurGodsAreDifferent Daedric Prince]] of Pestilence, has this fall within his sphere. Given [[AnthropomorphicPersonification the nature]] of most deities in the series, one could say that he is the very ''embodiment'' of pestilence. His idea of a "blessing" toward his followers is to [[BlessedWithSuck afflict them with disease]]. Peryite is connected to the creation of the [[MysticalPlague Thrassian Plague]], which was unleashed on Tamriel by the Sload ("slug-men" of Thras) in the 1st and wiped out half the continent's population. The ending of his ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'' quest implies that he is preparing a new plague meant to "cover the world" with his "blessing".
** ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]'':
*** PhysicalGod [[BigBad Dagoth Ur]] has channeled his divine powers into creating and spreading the Corprus Disease. Spread via Blight Storms and through those already infected, it turns its victims into {{Plague Zombie}}s with a bad case of BodyHorror and severe mental degradation. However, for his chosen few, he can mold how the disease changes them, turning them into various forms of [[{{Mooks}} Ash creatures]] or, eventually, into various lesser [[EliteMooks Dagoth creatures]].
*** The ''Tribunal'' expansion has Gedna Relvel, an ancient and powerful lich who is spreading the Crimson Plague via infected rats to Mournhold. Naturally, she must be stopped.
* Pestilence from ''[[VideoGame/{{Hexen}} Hexen II]]''.
* Dr. Thrax, a GLA general from ''VideoGame/CommandAndConquerGenerals''. He has a scarred face that he covers with a veil, as well as a [[BlackComedy morbid sense of humor]]. He got his degree from a mail-order college.
* Caulder/Stolos, the BigBad of ''VideoGame/AdvanceWars: Days of Ruin''. He used a SyntheticPlague called the Creeper to test the effects of "trauma from dying from infection" on the survivors of a world-ending apocalypse ForScience, and apparently thought it all good fun.
* Captain Quirk (yes, a parody of who you think) in ''VideoGame/SpaceQuestVTheNextMutation''. He is using his ship to illegally dump toxic waste on "unimportant" planets and ends up infected by the garbage.
* Thorne in ''VideoGame/TronTwoPointOh''. Alan Bradley ''does not bluff'' about the nasty consequences of going into cyberspace without the proper precautions in place... Thorne ends up as this ''thing'' that infects other Programs and overruns Encom's servers. [[spoiler: He ends up succumbing to the effects of it and an ass-kicking by the Infiltration Countermeasure Kernel]]
** SpiritualSuccessor Abraxas in ''VideoGame/TronEvolution'' has much the same MO, but a ''much'' more tragic and horrific backstory.
* The Darkspawn of ''Franchise/DragonAge'' are ([[OurOrcsAreDifferent among]] [[TheLegionsOfHell other]] [[FaceFullOfAlienWingWong things]]) a whole ''race'' of Plaguemasters, though [[GameplayAndStorySegregation your party won't need to worry about being infected]].
** That's because, in the case of the Gray Wardens at least [[spoiler: [[ZombieInfectee They're tainted with a slower acting version of the plague]], [[YouAreAlreadyDead so if you don't annihiliate yourself taking out the Archdemon, you just turn into an insane ghoul in 20-30 years]]. Seeing as the world is such a momumental CrapsackWorld, that even ''God'' has turned his back on it, even killing yourself against the Archdemon doesn't do much to improve anything]]
* [[ActionGirl Lilith]] in ''VideoGame/{{Borderlands}}'' has [[ElementalPowers elemental powers as her hat]], and although corrosives are mechanically acids, they spread like a virus, the elemental logo is a biohazard sign and the weapon descriptions ("Defiler", "Pestilent", "Infectious") reference disease. A class mod for her that focuses on this element is even called the Plaguebearer.
* Maya in [[VideoGame/{{Borderlands 2}} the sequel]] has more corrosive-focused powers, even having the ability to create a cloud of acid simply by shooting someone. She even has a special class mod that boosts the damage and chance of corrosive damage called Witch.
* ''Videogame/EverQuest'' has Bertoxxulous, an actual god of disease, with a Plane of Disease to call home.
* Mordekaiser in ''VideoGame/LeagueOfLegends'' is an odd example in that his in-game abilities are based on [[ExtraOredinary control of metal]], but is nevertheless drawn to disease and pollution and his touch causes sickness. It's suggested that his armor mostly protects those around him from the disease he would spread if not contained, although whether it's a prison or a courtesy is unknown.
** Twitch is another example, his "deadly venom" is apparently derived from sewage and many of his quotes allude to him being a [[TheBlackDeath plague rat.]]
* Rotund'jere the Necrolyte from ''VideoGame/{{Dota 2}}'' was a priest who was purposefully infected with a horrible plague as a punishment for embezzling people dying from it, and cursed with longevity so he could suffer a slow death at the hands of the disease. [[ThePunishment Instead of dying, he became empowered by it and decided to 'share' his new gift with the world.]]
* Qada, the Salve-Maker Asterisk holder of ''VideoGame/BravelyDefault'', uses this to exterminate his enemies, as well as some allies. All the better for him to profit via selling remedies. Not a pleasant person to say the least.
* The necromancer class of ''VideoGame/GuildWars2'' can easily become one of these if built properly, but their {{Plaguemaster}} tendencies really shine when they use their elite skill, ''Plague'', which turns them into a literal cloud of pestilence that damages, [[StandardStatusEffects poisons, bleeds, weakens, blinds, and cripples]] all enemies stupid enough to get too close. For extra malice, the necromancer can choose exactly when they wish to apply most of these conditions.
* ''Videogame/WarlordsBattlecry III'' has a whole bunch of these as an entire playable faction, the Plaguelords. Practically all of their units can infect enemies with their basic attacks, and their armies are composed of slimy {{Blob Monster}}s, rotting undead troops and not-so-dead priests, and mutated beasts like eyeballs and hydras.
* ''Videogame/TearsToTiara2'' has The King of Death. He magically spreads TheBlackDeath throughout the setting's counterpart to Western Europe, including areas controlled by his own side. He also turns all wheat into poisonous black wheat.
* ''Videogame/DarkSouls'':
** Gravelord Nito. In addition to his being the lord of the dead, he also is associated with disease and plague. This is how he contributed to the war against the Everlasting Dragons: he created a great plague that swept through the Dragons' forces. In the game itself, all of his attacks inflict the "Toxic" status effect. The "disasters" his Gravelord Servants perpetuate online are likened to a disease as well, being referred to as an "infection" and "spreading" to multiple players rather than just one at a time.
** Eingyi is a pyromancer from the Great Swamp, exiled for having committed the "heresy" of inventing the Poison Cloud and Toxic Cloud pyromancy spells. His [[BodyHorror egg-burdened]] state in the game itself prevents him from using these abilities, but he can teach them to the player if they earn his trust.
* Beatrix from ''VideoGame/{{Battleborn}}'' uses diseases either at range or using her allies as carriers for her contagions.
* Stukov from ''VideoGame/HeroesOfTheStorm'' plays this straight and inverts it at the same time. His skills utilize the pus and pustules from his body, and he relies on spreading them to his targets' allies. The inversion comes when you realize that his first ability infects and spreads... and yet it's a ''healing'' ability.[[/folder]]

[[folder:Web Original]]
* ''Wiki/SCPFoundation''
** [[http://scp-wiki.wikidot.com/scp-353 SCP-353]] is a woman that can collect, modify, and distribute diseases, up to and including the infamous 1918 strain of influenza. She temporarily experiences symptoms of the diseases as she's modifying them, but this doesn't dissuade her from doing it.
** [[http://scp-wiki.wikidot.com/scp-1249 SCP-1249 ("Pestilence")]]. SCP-1249 releases a liquid that contains infectious pathogens such as smallpox, leprosy, the bubonic plague and the Ebola virus. Anyone contacting the liquid can become infected with one or more of these diseases.
* The Plague Doctor from Franchise/TheFearMythos spreads disease wherever he goes. To a lesser extent, there are also a number of seemingly normal medical doctors who serve him, and intentionally spread disease to the people they're supposedly trying to save.

[[folder:Western Animation]]
* "The Common Cold" from ''WesternAnimation/CodenameKidsNextDoor''.
* From ''WesternAnimation/CourageTheCowardlyDog'', Conway The Contaminationist.
* ''WesternAnimation/{{Captain Planet|AndThePlaneteers}}'' villain Verminous Scumm, as his name suggests.
* [[PunnyName D'Compose]], an ''WesternAnimation/{{Inhumanoids}}'' villain, is capable of mutating normal animals and people into screeching, monstrous undead abominations. Fortunately, sunlight changes them back to normal.
* Decepticon chemist Oil Slick of ''WesternAnimation/TransformersAnimated''. He wears a domed helmet to protect himself from his own toxins he unleashes during battle and does not really care if [[WeHaveReserves his comrades are infected in his wake]].
* Dr. James Bent a.k.a. Overlord, the main villain of ''WesternAnimation/SpiralZone''. He tries to TakeOverTheWorld by creating a SyntheticPlague that turns people into {{Mind Control}}led, zombie-like "Zoners" with red patches on their faces.
* Played for laughs in an episode of ''FamilyGuy'' where Peter and Joe are playing increasingly extreme pranks on Quagmire (a Halloween tradition), and one "prank" includes infecting him with hepatitis C, only for him to reveal he already has it. Same thing with meningitis and gonorrea (in the latter case he's ''patient zero''). Eventually, they run out of known diseases, and Peter resorts to flying to Africa, catching a mosquito carrying a virus that hasnt been named yet, and having it bite Quagmire. This one works.

[[folder:Real Life]]
* Then there's the various tales of people with AIDS knowingly infecting unwitting victims for one reason or another. The most famous would probably be flight attendant Gaetan "Patient Zero" Dugas, though later evidence suggests that in his case at least, this is an exaggeration.
** There's been at least one case of a prisoner murdering a guard by jabbing him with a syringe filled with his own HIV-infected blood.
** Tragically ([[MoralEventHorizon or horrifically]]), [[RapeIsASpecialKindOfEvil raping victims to deliberately spread AIDS]] is a tactic used commonly by AIDS-infected militia members in Sub-Saharan Africa.
* Any Bio-terrorist qualifies.
* Some places believed (or still believe) that [[VirginPower sex with a virgin will cure whatever diseases they have]]. [[SexualHarassmentAndRapeTropes (And, no, it doesn't have to be consensual, either.)]] Needless to say, this does not work, and often ends with the (now former) virgin getting sick, too.